Blood-activating and pain-relieving transdermal plaster and preparation method thereof

Abstract

The invention discloses a blood-activating and pain-relieving transdermal plaster and a preparation method thereof, and relates to the technical field of plasters, the key points of the technical scheme are as follows: S1, soaking a medicine guide pad with blood-activating and pain-relieving wine until the medicine guide pad is moist and does not drip water; s2, the tail end of the tail wire is placed on an anti-allergic non-woven fabric adhesive tape and covered and adhered with a conductive film, and an electrode at the tail end of the tail wire is connected with the conductive film; s3, sticking the medicine guide pad manufactured in the step S1 to a conductive film, and then covering the anti-allergic non-woven fabric adhesive tape with an anti-sticking protective film to obtain a plaster; and S4, packaging, sealing and storing the plaster obtained in the step S3. The traditional Chinese medicine is good in clinical curative effect and has good effects of relieving pain and diminishing swelling; meanwhile, the device can be conveniently fixed at a treatment part and is convenient for workers to operate.

Description

Technical Field

[0001] The invention relates to the technical field of plasters, and more particularly to a blood-activating and pain-relieving medicated plaster and a preparation method thereof. Background Art

[0002] With changing lifestyles and an aging population, the number of stroke patients has been increasing year by year in recent years. For example, in my country, approximately 2 million new stroke patients are diagnosed annually. Shoulder-hand syndrome (SHS) is one of the most common complications of stroke, manifesting as pain, edema, and limited joint motion on the hemiplegic shoulder and hand. This condition severely impairs upper limb motor function, significantly impacting patients' quality of life and contributing to disability. Therefore, finding effective treatments for SHS has become a pressing clinical challenge.

[0003] Huoxue Antong Liquor is an in-house formulation of our hospital. It contains herbaceous loquat, notopterygium wilfordii, stir-fried atractylodes lancea, dipsaccharin, peach kernel, geranium, red peony root, angelica sinensis, herbaceous stalks, raw aconite, cinnamon twig, Achyranthes bidentata, papaya, salvia miltiorrhiza, safflower, prepared rehmannia root, serpentine snake, spatholobi cuneata, and antonin vine. It has the effects of dispelling wind and dampness, promoting blood circulation, and alleviating pain. Huoxue Antong Liquor is widely used clinically and has demonstrated excellent efficacy in treating shoulder-hand syndrome, cervical spondylosis, frozen shoulder, lumbar muscle strain, and knee osteoarthritis. It can significantly improve VAS pain scores and promote functional recovery.

[0004] Huoxue Antong Liquor can be taken orally to reduce swelling and relieve pain. For chronic pain conditions, it can also be applied directly externally for localized effects. Clinically, we generally use Traditional Chinese Medicine (TCM) targeted drug penetration methods for treatment, which can directly reach the affected area, offering advantages such as rapid onset and ease of use. Preliminary research by the inventors has found that using Huoxue Antong Liquor via TCM targeted drug penetration therapy to treat post-stroke shoulder-hand syndrome has excellent analgesic and detumescent effects. In light of this, the inventors have proposed Huoxue Antong Translucent Plaster and its preparation method. Summary of the Invention

[0005] The invention aims to provide a Huoxue Antong Tou Medicinal Plaster and a preparation method thereof, which can improve and treat shoulder-hand syndrome and is convenient for medical personnel to operate.

[0006] The above technical objectives of the present invention are achieved through the following technical solutions: a blood-activating and pain-relieving plaster and a preparation method thereof, comprising the following steps:

[0007] S1. Soak the medication pad with Huoxue Antong Liquor until it is damp but not dripping.

[0008] S2. Place the end of the tail wire on an anti-allergic non-woven tape, cover it with a conductive film, and adhere it. Connect the electrode at the end of the tail wire to the conductive film.

[0009] S3. The drug-conducting pad produced in step S1 is adhered to the conductive film, and then covered with an anti-sticking protective film on the anti-allergic non-woven tape;

[0010] S4. Package the patch obtained in step S3 and seal it for storage.

[0011] The present invention is further configured as follows: in step S1, the size of the drug guiding pad is 4 cm*6 cm.

[0012] The present invention is further configured as follows: in step S2, the size of the anti-allergic non-woven tape is 9 cm*7 cm.

[0013] The present invention is further configured as follows: in step S2, the size of the conductive film is 4 cm*6 cm.

[0014] The present invention also provides a blood-activating and pain-relieving medicated plaster, which is prepared by any of the above methods.

[0015] The blood-activating and pain-relieving wine in the present invention is a preparation prepared in the inventor's hospital, and is composed of mistletoe, notopterygium wilfordii, fried atractylodes lancea, knotweed, peach kernel, geranium, red peony root, angelica, bark medicine, raw aconite, cassia twig, Achyranthes bidentata, papaya, salvia miltiorrhiza, safflower, prepared rehmannia root, black-necked snake, safflower vine, and analgesic vine.

[0016] Mulberry Parasite: Bitter, sweet, neutral. Enters the Liver and Kidney meridians. Relieves rheumatism, nourishes the liver and kidneys, strengthens the bones and tendons, and stabilizes the fetus. Used for rheumatic pain, soreness of the waist and knees, weakness of the bones and tendons, metrorrhagia, bleeding during pregnancy, restless fetuses, and dizziness.

[0017] Qiang Huo: Pungent, bitter, and warm. Enters the Bladder and Kidney meridians. Dispels cold, dispels wind and dampness, and relieves pain. Used for colds, headaches, stiff neck, rheumatic pain, and shoulder and back pain.

[0018] Fried Atractylodes lancea with bran: It tastes pungent and bitter, is warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of drying dampness, strengthening the spleen, removing rheumatism, and improving eyesight.

[0019] Dipsacus root: Bitter, pungent, slightly warm. Enters the Liver and Kidney meridians. It nourishes the liver and kidneys, strengthens tendons and bones, heals fractures, and relieves metrorrhagia. It is used for liver and kidney deficiency, soreness of the waist and knees, rheumatic pain, injuries from falls, tendon injuries and fractures, metrorrhagia, and miscarriage. Dipsacus root prepared with wine is often used for rheumatic pain, injuries from falls, tendon injuries and fractures. Dipsacus root prepared with salt is often used for soreness of the waist and knees.

[0020] Peach kernel: Bitter, sweet, neutral. Enters the Heart, Liver, and Large Intestine meridians. Promotes blood circulation, removes blood stasis, moistens the intestines and promotes bowel movements, relieves cough and asthma. Used for amenorrhea, dysmenorrhea, lumps and masses, lung and intestinal abscesses, injuries from falls, constipation due to dry intestines, and cough and asthma.

[0021] Geranium: Pungent, bitter, neutral. Enters the Liver, Kidney, and Spleen meridians. Dispels rheumatism, dredges the meridians, and relieves diarrhea. Used for rheumatic pain, numbness, cramps, muscle and bone aches, and diarrhea.

[0022] Red Peony Root: Bitter, slightly cold. Enters the Liver Meridian. Clears heat, cools blood, disperses blood stasis, and relieves pain. Used for heat invading the blood, warm toxins causing rash, hematemesis and epistaxis, red and swollen eyes, liver depression and flank pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps and masses, injuries from falls, and carbuncles and ulcers.

[0023] Angelica sinensis: Sweet, pungent, and warm. It enters the liver, heart, and spleen meridians. It nourishes and promotes blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for blood deficiency, sallow complexion, dizziness, palpitations, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic pain, injuries from falls, carbuncles, ulcers, and constipation caused by dry intestines. Angelica sinensis wine is used to promote blood circulation and promote menstruation. It is used for amenorrhea, dysmenorrhea, rheumatic pain, and injuries from falls.

[0024] Lecithin: Pungent; warm; slightly toxic. Enters the Lung, Liver, and Spleen meridians. Dispels wind and cold, promotes blood circulation and relieves pain, detoxifies and reduces swelling. Treats wind-cold-damp arthritis, abdominal pain and diarrhea, sore throat, swollen and painful gums, unexplained swellings, injuries from falls, snake bites, hematemesis, and epistaxis.

[0025] Raw Radix Aconiti Kusnezoffii: Pungent, bitter, hot; highly toxic. It enters the Heart, Liver, Kidney, and Spleen meridians. It dispels wind and dampness, warms the meridians, and relieves pain. It is used for wind-cold-damp arthritis, joint pain, cold pain in the heart and abdomen, hernia pain, and as anesthesia and analgesia.

[0026] Cinnamon Twig: Pungent, sweet, and warming. It enters the Heart, Lung, and Bladder meridians. It induces sweating and relaxes muscles, warms and unclogs the meridians, boosts yang and transforms qi, and balances and descends qi. It is used for colds, cold pain in the abdomen due to wind and cold, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and typhoid fever.

[0027] Achyranthes bidentata: Bitter, sweet, sour, neutral. Enters the Liver and Kidney meridians. Removes blood stasis, tonifies the liver and kidneys, strengthens tendons and bones, promotes urination and relieves stranguria, and guides blood downward. Used for amenorrhea, dysmenorrhea, soreness of the waist and knees, weakness of tendons and bones, stranguria, edema, headache, dizziness, toothache, mouth ulcers, hematemesis, and epistaxis.

[0028] Papaya: Sour, warm. Enters the Liver and Spleen meridians. It relaxes tendons and activates collaterals, harmonizes the stomach, and eliminates dampness. It is used for dampness-induced stiffness and cramps, soreness and heaviness in the waist and knees, vomiting and diarrhea due to summer heat and dampness, cramps and pain, and beriberi and edema.

[0029] Salvia miltiorrhiza: Bitter, slightly cold. Enters the Heart and Liver meridians. It promotes blood circulation, dispels blood stasis, relieves menstrual pain, clears the heart and relieves restlessness, and cools blood and eliminates carbuncle. It is used for chest pain, abdominal pain, and flank pain, accumulation of masses, pain due to heat, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, and sores and swelling.

[0030] Safflower: Pungent, warm. Targets the Heart and Liver meridians. Promotes blood circulation and menstruation, dissipates blood stasis, and relieves pain. Used for amenorrhea, dysmenorrhea, lochia retention, lumps and masses, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and flanks, injuries from falls, and sores and swelling.

[0031] Rehmannia root: Sweet, slightly warm. Enters the liver and kidney meridians. Replenishes blood and nourishes yin, replenishes essence and fills the marrow. Used for blood deficiency, sallow complexion, palpitations, irregular menstruation, metrorrhagia, liver and kidney yin deficiency, soreness of the waist and knees, bone steaming and hot flashes, night sweats and spermatorrhea, internal heat and thirst, dizziness, tinnitus, and premature graying of hair.

[0032] Black-striped snake: sweet, neutral. Enters the liver meridian. Expels wind, dredges the meridians, and stops spasms. Used for rheumatism, numbness, cramps, and stroke. Obliquity, hemiplegia, convulsions, tetanus, leprosy, scabies.

[0033] Sargentodoxae: Bitter, neutral. Enters the large intestine and liver meridians. Clears heat and detoxifies, promotes blood circulation, dispels wind and relieves pain. Used for abdominal pain caused by intestinal carbuncle, ulcers caused by heat toxins, amenorrhea, dysmenorrhea, swelling and pain from falls, and rheumatic pain.

[0034] Antongteng: Light, slightly astringent, neutral. Enters the Lung and Stomach meridians. Dispels wind and relieves pain, relaxes tendons and activates collaterals, draws pus and reduces swelling. Used for traumatic injuries, sprains, rheumatic joint pain, fractures, and carbuncles and swelling.

[0035] In summary, the present invention has the following beneficial effects:

[0036] 1. The present invention uses Huoxue Antong Tou Medicated Plaster to treat post-stroke shoulder-hand syndrome, which has good clinical efficacy and good analgesic and detumescent effects;

[0037] 2. Convenient treatment: the blood-activating and pain-relieving patch provided by the present invention can be pasted on the patient's treatment area after tearing off the packaging box. The tail wire is connected to the traditional Chinese medicine directional drug-penetrating therapeutic instrument to achieve the treatment purpose, eliminating the steps of soaking and wringing out the gauze by medical staff, and quickly treating the patient. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 This is a flow chart of the preparation method of Huoxue Antong Tou Medicated Plaster according to an embodiment of the present invention;

[0039] Figure 2 This is a real picture of the Huoxue Antong Tou medicine plaster in the embodiment of the present invention;

[0040] Figure 3 1. It is a structural diagram of the Huoxue Antong Tou medicine patch in an embodiment of the present invention.

[0041] In the picture: 1. Anti-allergic non-woven tape; 2. Tail wire; 3. Electrode; 4. Conductive film; 5. Drug guide pad; 6. Anti-sticking protective film. DETAILED DESCRIPTION

[0042] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0043] Example 1:

[0044] The preparation method of Huoxue Antong Tou medicine plaster is as follows: Figure 1 As shown, the following steps are included:

[0045] S1. Soak the medicine guide pad with blood-activating and pain-relieving wine until it is moist but not dripping. The size of the medicine guide pad is 4cm*6cm.

[0046] S2. Place the end of the tail wire on an anti-allergic non-woven tape, cover it with a conductive film, and adhere it. Connect the electrode at the end of the tail wire to the conductive film. The anti-allergic non-woven tape should be 9 cm by 7 cm, and the conductive film should be 4 cm by 6 cm.

[0047] S3. The drug-conducting pad produced in step S1 is adhered to the conductive film, and then covered with an anti-stick protective film on the anti-allergic non-woven tape to obtain a plaster;

[0048] S4. Package the patch obtained in step S3 and seal it for storage.

[0049] The blood-activating and pain-relieving wine is prepared by soaking mistletoe, angelica root, stir-fried atractylodes lancea, knotweed, peach kernel, geranium, red peony root, angelica, bark medicine, raw aconite, cassia twig, Achyranthes bidentata, papaya, salvia miltiorrhiza, safflower, rehmannia root, black-necked snake, safflower clove, and pain-relieving vine in wine.

[0050] The present invention also provides a blood-activating and pain-relieving medicated plaster, which is prepared by the above method and has a specific structure as follows: Figure 2 and Figure 3 It consists of an anti-stick protective film, a drug-conducting pad, a conductive film, an anti-allergic non-woven adhesive tape, a tail wire, and electrodes.

[0051] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A method for preparing a blood-activating and pain-relieving medicated plaster, which is characterized by: The steps include: S1. Soak the medication pad with Huoxue Antong Liquor until it is damp but not dripping. S2. Place the end of the tail wire on an anti-allergic non-woven tape, cover it with a conductive film, and adhere it. Connect the electrode at the end of the tail wire to the conductive film. S3. The drug-conducting pad produced in step S1 is adhered to the conductive film, and then covered with an anti-stick protective film on the anti-allergic non-woven tape to obtain a plaster; S4. Package the patch obtained in step S3 and seal it for storage.

2. The preparation method of the Huoxue Antong Touyao Plaster according to claim 1, wherein: In step S1, the size of the drug conductive pad is 4 cm*6 cm.

3. The preparation method of the Huoxue Antong Touyao Plaster according to claim 1, wherein: In step S2, the size of the anti-allergic non-woven tape is 9 cm*7 cm.

4. The preparation method of the Huoxue Antong Tou Medicated Plaster according to claim 1, wherein: In step S2, the size of the conductive film is 4 cm*6 cm.

5. The preparation method of the Huoxue Antong Touyao Plaster according to claim 1, wherein: The blood-activating and pain-relieving wine is prepared by soaking mistletoe, angelica root, stir-fried atractylodes lancea with bran, knotweed, peach kernel, geranium, red peony root, angelica, bark medicine, raw aconite, cassia twig, cyperus, papaya, salvia miltiorrhiza, safflower, rehmannia root, jasmine, safflower ...

6. Huoxue Antong Tou Medicated Plaster, which is characterized by: Prepared by the method described in any one of claims 1 to 5.

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