Traditional Chinese medicine hair-growing concentrated solution as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of daily chemical products, and particularly relates to a traditional Chinese medicine hair-growing concentrated solution and a preparation method and application thereof. The traditional Chinese medicine concentrated solution integrating blood replenishing, hair nourishing, kidney tonifying, hair blacking, blood activating, skin penetrating, hair growing and activating and scalp environment adjusting is prepared through innovative traditional Chinese medicine compatibility and combination, and the shampoo prepared from the traditional Chinese medicine concentrated solution can remarkably reduce the amount of alopecia and promote growth of new hair and has the good effects of removing dandruff, controlling oil, growing hair and preventing alopecia.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical products, and particularly relates to a traditional Chinese medicine hair growth concentrate and a preparation method and application thereof. Background Art

[0002] The field of hair loss treatment has long been plagued by the dual technical bottlenecks of a strong reliance on chemical drugs and the ineffectiveness of traditional Chinese medicine preparations. Minoxidil, a leading topical chemotherapy drug, while effective in promoting hair growth, suffers from significant clinical drawbacks: first, it requires a high-frequency twice-daily dosing schedule, leading to poor patient compliance (clinical dropout rates >40%); second, its mechanism of action is reversible, with over 90% of users experiencing rebound hair loss after discontinuation; and third, long-term use can easily trigger adverse reactions such as contact dermatitis. Clinical statistics show a 5% incidence of local allergic reactions, severely limiting its sustainable application.

[0003] In the field of traditional Chinese medicine for hair growth and hair loss prevention, many commercially available products suffer from both flawed formulations and effectiveness. Firstly, these products generally employ simple compounding processes, with active ingredients (such as Platycladus orientalis leaf extract and Polygonum multiflorum extract) often added at levels below 0.5%, failing to achieve the effective therapeutic concentrations documented in TCM texts. Secondly, formulation design lacks the guidance of classical compatibility theory, often relying on the simple addition of single ingredients, resulting in a lack of synergistic effects. More critically, traditional TCM topical preparations are limited by their large molecular weight (most active ingredients have molecular weights >500 Da) and insufficient lipid solubility. Their transdermal permeability coefficients are generally less than 0.1 cm / h, making it difficult to penetrate the epidermal barrier and reach the dermis (>3 mm), where hair follicles reside. This creates a technical dilemma: "active ingredients cannot penetrate."

[0004] In terms of formulation carriers, although conventional silicone oil shampoo products can temporarily improve the appearance of hair, long-term use will cause silicone substances to deposit at the opening of hair follicles, forming a physical blocking barrier, which not only affects drug penetration, but also aggravates the miniaturization process of hair follicles and causes hair loss. Summary of the Invention

[0005] Based on the above technical problems, the purpose of the present invention is to provide a traditional Chinese medicine hair growth concentrate and its preparation method and application.

[0006] To achieve the above object, the technical solution adopted by the present invention is: The present invention provides a traditional Chinese medicine hair-growth concentrated solution, and the preparation steps of the traditional Chinese medicine hair-growth concentrated solution are as follows: S1. Boil ginseng in water for 1-3 hours to separate the solid and liquid. The solid component is ginseng residue, and the liquid component is ginseng extract. S2. Mix ginseng residue, angelica, astragalus, Millettia reticulata, Polygonum multiflorum, drynaria root, mulberry, Ecliptae, Ligustrum lucidum, Chuanxiong, Herba scutellariae, moutan bark, mulberry leaf, Platycladus orientalis leaf, ginger, mulberry bark, Sophora flavescens, Zanthoxylum bungeanum, Sapindus mukorossi, and water in a mass ratio of 2-4:1-3:1-3:1-3:1-3:1-3:1-3:1-3:3-5:3-5:3-5:3-5:3-5:3-5:4-6:3-5:1-3:2-4:1-3:2-4:95-105, decoct for 0.5-1.5 hours, and then separate the solid and liquid to obtain a first decoction and a mixed residue. Mix the mixed residue with water, decoct for 0.5-1.5 hours, and filter to obtain a second decoction. Combine the first decoction and the second decoction to obtain a mixed solution. S3. Mixing the ginseng extract and the mixed solution to obtain a Chinese medicine hair growth concentrate.

[0007] The present invention uses an innovative combination of traditional Chinese medicines to prepare a traditional Chinese medicine concentrate with the five functions of nourishing blood and hair, nourishing the kidney and blackening hair, promoting blood circulation and penetrating the skin, activating hair growth, and regulating the scalp environment by combining ginseng, angelica, astragalus, Millettia reticulata, Polygonum multiflorum, Rhizoma Drynariae, mulberry, Ecliptae, Fructus Ligustri Lucidi, Rhizoma Chuanxiong, Herba Polygoni Multiflori, Paeonia Suffruticosae, mulberry leaves, Platycladus orientalis leaves, ginger, Morus alba bark, Sophora flavescens, Zanthoxylum bungeanum, and Sapindus mukorossi in specific proportions. The concentrate can significantly reduce the amount of hair loss, promote new hair growth, and has good effects in removing dandruff, controlling oil, and promoting hair growth and preventing hair loss.

[0008] Furthermore, the mass ratio of ginseng to water in S1 is 0.5~1.5:95~105.

[0009] Furthermore, the mass ratio of the mixed medicinal residue to water in S2 is 0.5-1.5:1-3.

[0010] Furthermore, the volume ratio of the first decoction liquid to the second decoction liquid in S2 is 0.5~1.5:0.5~1.5.

[0011] Furthermore, the volume ratio of the ginseng extract and the mixed solution in S3 is 1-3:20-25.

[0012] The present invention also provides use of the traditional Chinese medicine hair growth concentrate in preparing traditional Chinese medicine hair growth shampoo. The traditional Chinese medicine hair growth shampoo is prepared by compounding the traditional Chinese medicine hair growth concentrate with a surfactant and functional components.

[0013] Furthermore, the surfactant comprises: The mass ratio of cocamidopropyl betaine to traditional Chinese medicine hair growth concentrate is 25-30:5-15; The mass ratio of coconut oil fatty acid potassium glycinate to traditional Chinese medicine hair growth concentrate is 25-30:5-15; The mass ratio of coconut oil monoethanolamide to traditional Chinese medicine hair growth concentrate is 25~30:1~3.

[0014] Furthermore, the following functional components are also included: The amount of menthol added is 0.1%~1% of the volume of the traditional Chinese medicine hair growth concentrated liquid; The amount of silk protein softener added is 1%~3% of the volume of the traditional Chinese medicine hair growth concentrated liquid; The amount of xanthan gum added is 0.5%~1% of the volume of the concentrated liquid of traditional Chinese medicine for hair growth; The amount of antibacterial agent Genma BP added is 0.5%~1% of the volume of the traditional Chinese medicine hair growth concentrated liquid.

[0015] The present invention has the following beneficial effects: The present invention uses an innovative combination of Chinese herbs, including ginseng, angelica, astragalus, Millettia reticulata, Polygonum multiflorum, Drynaria fortunei, mulberry, Ecliptae herba, Ligustrum lucidum fruit, Chuanxiong, Herba schizonepetae, moutan bark, mulberry leaf, Platycladus orientalis leaf, ginger, Morus alba bark, Sophora flavescens, Zanthoxylum bungeanum, and Sapindus mukorossi, in specific proportions to produce a Chinese herbal hair growth concentrate, which significantly improves the effectiveness and safety of anti-hair loss products. Specific effects include:

[0016] 1. Improve the transdermal absorption rate of the effective ingredients of traditional Chinese medicine, so that they can penetrate deep into the hair follicles to exert their effects, achieving significant effects in oil control, dandruff removal, hair growth and hair loss prevention.

[0017] 2. Achieve the stable presence of high-concentration Chinese herbal ingredients in shampoo and enhance product efficacy.

[0018] 3. Silicone-free formula avoids the risk of hair follicle clogging and improves hair conditioning effect.

[0019] 4. User feedback is positive, with significant reductions in hair loss, new hair growth, and increased hair volume. After shampooing, hair is left feeling refreshed and fluffy, and dandruff is reduced, improving user satisfaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a sample picture of Chinese herbal hair growth shampoo. DETAILED DESCRIPTION

[0021] The present invention is described in detail below with reference to specific examples, but these examples should not be construed as limiting the present invention. Unless otherwise specified, the technical means used in the following examples are conventional means well known to those skilled in the art, and the materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0022] Example 1: Preparation of oil-controlling, anti-dandruff and anti-hair loss shampoo.

[0023] This invention is based on the Traditional Chinese Medicine (TCM) concepts of "hair is the residue of blood," "the essence of the kidney is in the hair," and "the liver and kidney are of the same origin," and adheres to the TCM circulation theory of "Qi and blood - liver and kidney - hair quality." This overcomes the limitations of traditional Chinese medicine absorption through the skin caused by purely tonic effects. By incorporating traditional Chinese medicine ingredients that promote blood circulation and dredge meridians into the formula, this invention forms a trinity of "tonifying Qi and blood - nourishing the liver and kidney - promoting blood circulation and dredge meridians" to prevent hair loss and promote growth.

[0024] Traditional Chinese medicines that improve the scalp's microenvironment are also added, achieving a triple intervention system of "nourishment + unblocking + protection." Finally, by incorporating herbs that directly promote hair growth, a five-in-one traditional Chinese medicine hair growth shampoo is formulated: nourishing blood and hair (ginseng, angelica, astragalus, Spatholobi), tonifying the kidneys and darkening hair (Polygonum multiflorum, Drynaria fortunei, mulberry, Eclipta prostrata, Ligustrum lucidum), promoting blood circulation and transdermal penetration (Chuanxiong, Radix Polygoni Multiflori, Paeonia lactiflora), stimulating hair growth (mulberry leaf, Platycladus orientalis leaf, ginger), and regulating the hair environment (morus alba bark, sophora flavescens, Zanthoxylum bungeanum, Sapindus mukorossi).

[0025] 1. Preparation of Chinese herbal medicine concentrates.

[0026] 1. Preparation of ginseng extract: Cut ginseng into thin slices and mix with water in a mass ratio of 1:100, then heat to boiling, maintain a slight boiling state and simmer for 2 hours, filter the decoction to obtain ginseng extract and ginseng residue.

[0027] 2. Mixed extraction: Mix ginseng residue, angelica, astragalus, Millettia reticulata, Polygonum multiflorum, Drynaria fortunei, mulberry, Ecliptae herba, Ligustrum lucidum, Chuanxiong, Herba scutellariae, Paeonia suffruticosae moutan, mulberry leaf, Platycladus orientalis leaf, ginger, Morus alba bark, Sophora flavescens, Zanthoxylum bungeanum, Sapindus mukorossi, and deionized water in a mass ratio of 3:2:2:2:2:2:2:2:4:4:2:2:2:2:5:4:2:3:2:3:100. Heat to boiling and simmer for 1 hour. Pour out the first decoction. Add water of the same mass ratio to the residue and decoct for 1 hour to obtain a second decoction.

[0028] The first decoction and the second decoction were combined in a volume ratio of 1:1 to obtain a mixed solution.

[0029] 4. Combining the Chinese herbal concentrated solutions: Mix the ginseng extract and the mixed solution in a volume ratio of 2:22 to obtain the Chinese herbal hair growth concentrated solution.

[0030] 2. Preparation of shampoo.

[0031] 1. Functional additives: Heat the Chinese herbal hair growth concentrate to 50°C. Add in the following ingredients in order:

[0032] 0.5% volume fraction of menthol enhances the cooling sensation and scalp absorption rate.

[0033] The volume fraction of silk protein softener is 2%, which improves the smoothness of hair.

[0034] The volume fraction of xanthan gum is 0.6%, which enhances the stability and viscosity of the shampoo.

[0035] Stir well to ensure all ingredients are fully dissolved.

[0036] 2. Add surfactant: Add the following ingredients in sequence: Cocamidopropyl betaine is added as the main surfactant in a mass ratio of 27:10 between traditional Chinese medicine hair growth concentrate and cocamidopropyl betaine to provide good cleaning effect and mildness.

[0037] Coconut oil fatty acid potassium glycinate was added in a mass ratio of 27:10 between traditional Chinese medicine hair growth concentrate and coconut oil fatty acid potassium glycinate as an auxiliary surfactant to enhance foaming and cleaning ability.

[0038] Coconut oil monoethanolamide is added in a mass ratio of 27:2 between traditional Chinese medicine hair growth concentrate and coconut oil monoethanolamide as a thickener and conditioner to improve the texture of the shampoo.

[0039] Stir thoroughly to ensure the surfactant is evenly dispersed.

[0040] Add antibacterial agent: add 0.6% volume fraction of Jema BP (Wuhan Huaxiang Kejie Biotechnology Co., Ltd.) and stir evenly to obtain Figure 1 The semi-fluid viscous herbal concentrate shampoo shown.

[0041] 3. Test the pH value: Use a pH meter to test the pH value of the shampoo. The pH value was measured multiple times and was between 5.5 and 6.5, which is in line with the scalp microenvironment and the product is mild and non-irritating.

[0042] Verification example 1: Optimization of the extract mixing ratio.

[0043] 1. Optimization of the mixing ratio of different extracts.

[0044] To verify the effects of different volume ratios of ginseng extract and mixed solution on the effectiveness of shampoo, the following experimental groups were set up: A: ginseng extract and mixed solution were mixed at a volume ratio of 2:22 to obtain a traditional Chinese medicine hair growth concentrate. B: ginseng extract and mixed solution were mixed at a volume ratio of 3:21 to obtain a traditional Chinese medicine hair growth concentrate. C: ginseng extract and mixed solution were mixed at a volume ratio of 6:18 to obtain a traditional Chinese medicine hair growth concentrate. D: ginseng extract and mixed solution were mixed at a volume ratio of 1:23 to obtain a traditional Chinese medicine hair growth concentrate.

[0045] The remaining steps are the same as in Example 1.

[0046] 2. Inspection of usage effect.

[0047] Sixty volunteers aged 18 to 50 were selected. The subjects had symptoms consistent with excessive dandruff, such as greasy hair and flaky white scales, and had severe hair loss.

[0048] After wetting hair, apply an appropriate amount of the concentrated Chinese herbal shampoo of the present invention to the hair and gently massage to create a lather. Simultaneously, gently massage the scalp to dilate the capillaries beneath the scalp, increasing blood flow and helping the shampoo nourish and penetrate the hair roots. After 15 minutes, rinse with warm water. Use the shampoo three times a week for three consecutive months and then analyze the participants' shampooing experience. Table 1 summarizes the participants' experience.

[0049] Table 1: Statistics of subjects’ experience According to the survey results of volunteers in experimental groups A, B, C and D, as shown in Table 1, the overall evaluation of experimental group A is better than that of B, C and D. It can be seen that by optimizing the combination of various ingredients, experimental group A has a good shampooing experience, namely, excellent oil control, anti-dandruff and anti-hair loss effects.

[0050] It should be noted that when the claims of the present invention involve numerical ranges, it should be understood that the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. In order to avoid redundancy, the present invention describes preferred embodiments.

[0051] Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0052] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such changes and modifications fall within the scope of the claims and their equivalents, the present invention is intended to include such changes and modifications.

Claims

1. A Chinese herbal hair growth concentrate, characterized in that: The preparation steps of the traditional Chinese medicine hair growth concentrate are as follows: S1. Boil ginseng in water for 1-3 hours to separate the solid and liquid. The solid component is ginseng residue, and the liquid component is ginseng extract. S2. Mix ginseng residue, angelica, astragalus, Millettia reticulata, Polygonum multiflorum, drynaria root, mulberry, Ecliptae, Ligustrum lucidum, Chuanxiong, Herba scutellariae, moutan bark, mulberry leaf, Platycladus orientalis leaf, ginger, mulberry bark, Sophora flavescens, Zanthoxylum bungeanum, Sapindus mukorossi, and water in a mass ratio of 2-4:1-3:1-3:1-3:1-3:1-3:1-3:1-3:3-5:3-5:3-5:3-5:3-5:3-5:4-6:3-5:1-3:2-4:1-3:2-4:95-105, decoct for 0.5-1.5 hours, and then separate the solid and liquid to obtain a first decoction and a mixed residue. Mix the mixed residue with water, decoct for 0.5-1.5 hours, and filter to obtain a second decoction. Combine the first decoction and the second decoction to obtain a mixed solution. S3. Mixing the ginseng extract and the mixed solution to obtain a Chinese medicine hair growth concentrate.

2. The Chinese medicine hair growth concentrate according to claim 1, characterized in that The mass ratio of ginseng to water in S1 is 0.5-1.5:95-105.

3. The Chinese medicine hair growth concentrate according to claim 1, characterized in that The mass ratio of the mixed medicinal residue to water in S2 is 0.5-1.5:1-3.

4. The Chinese herbal hair growth concentrate according to claim 1, characterized in that: The volume ratio of the first decoction liquid to the second decoction liquid in S2 is 0.5-1.5:0.5-1.

5.

5. The Chinese herbal hair growth concentrate according to claim 1, characterized in that: The volume ratio of the ginseng extract and the mixed solution in S3 is 1-3:20-25.

6. Use of the traditional Chinese medicine hair growth concentrate according to claim 1 in preparing traditional Chinese medicine hair growth shampoo, characterized in that: The traditional Chinese medicine hair growth shampoo is prepared by compounding a traditional Chinese medicine hair growth concentrate, a surfactant and functional components.

7. The use according to claim 6, characterized in that The surfactant comprises: The mass ratio of cocamidopropyl betaine to traditional Chinese medicine hair growth concentrate is 25-30:5-15; The mass ratio of coconut oil fatty acid potassium glycinate to traditional Chinese medicine hair growth concentrate is 25-30:5-15; The mass ratio of coconut oil monoethanolamide to traditional Chinese medicine hair growth concentrate is 25~30:1~3.

8. The use according to claim 6, characterized in that Also includes the following functional components: The amount of menthol added is 0.1%~1% of the volume of the traditional Chinese medicine hair growth concentrated liquid; The amount of silk protein softener added is 1%~3% of the volume of the traditional Chinese medicine hair growth concentrated liquid; The amount of xanthan gum added is 0.5%~1% of the volume of the concentrated liquid of traditional Chinese medicine for hair growth; The amount of antibacterial agent Genma BP added is 0.5%~1% of the volume of the traditional Chinese medicine hair growth concentrated liquid.

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