Flexible epicardial cooling patch for minimally invasive surgery and use method of flexible epicardial cooling patch

Abstract

The invention belongs to the field of medical surgical articles, and particularly relates to a viscous dressing for minimally invasive surgery, in particular to an epicardium flexible cooling patch for minimally invasive surgery and a use method of the epicardium flexible cooling patch. The epicardial flexible cooling patch comprises a heat absorption layer, a plurality of heat absorption capsules are arranged in the heat absorption layer; the adhesion layer is arranged on one side of the microcapsule layer, and the side, away from the heat absorption layer, of the adhesion layer is provided with a pasting face; wherein the heat absorption capsule comprises an inner cavity, an outer cavity and a diaphragm for separating the inner cavity from the outer cavity, and the inner cavity and the outer cavity are internally provided with a solvent and a heat absorbent respectively; the heat absorption layer and the adhesion layer are flexible layers; the heat absorption layer and the adhesion layer are in a curled state and are fed into the thoracic cavity through a minimally invasive wound, then the heat absorption layer and the adhesion layer are unfolded through operating forceps, then the flexible epicardium cooling patch is spread on the surface of the heart through the adhesion layer, and finally the heat absorption layer is slightly pressed through operating forceps tips so that the diaphragm can be damaged. The solvent in the inner cavity and the outer cavity is mixed and dissolved with the heat absorbing agent, and then heart surface heat is absorbed through the adhesion layer.

Description

Technical Field

[0001] The present invention belongs to the field of medical surgical supplies, and specifically relates to an adhesive dressing for minimally invasive surgery, and more particularly to an epicardium flexible cooling patch for minimally invasive surgery and a method of using the patch. Background Art

[0002] Currently, the cooling method used in clinical practice for cardiac protection mainly relies on the use of open CPB.

[0003] During cardiopulmonary bypass (Cardiopulmonary Bypass) surgery, ice chips are applied directly to the heart's surface to achieve localized myocardial cooling. This method, relatively easy to implement during traditional midline thoracotomy, can significantly reduce myocardial metabolic rate and mitigate ischemia-reperfusion injury. The principle is that hypothermia reduces the basal metabolic rate of myocardial cells, which, when combined with cardioplegic solutions, can provide effective myocardial protection.

[0004] However, ice chips can easily slip during application and can cause nonspecific hypothermic damage to adjacent tissues, such as the phrenic nerve, diaphragm, and lungs, posing a safety risk. Furthermore, this type of cooling method requires high surgical exposure, often requiring full exposure of the heart, making it unsuitable for the currently widely used minimally invasive approaches.

[0005] Therefore, there is an urgent need to design a flexible epicardial cooling patch for minimally invasive surgery and its use method to solve the technical problems of using ice chips for cooling during the above-mentioned open CPB surgery, which are easy to slip during application and may cause nonspecific hypothermia damage to adjacent tissues such as the phrenic nerve, diaphragm, and lungs. At the same time, ice chip cooling requires the heart to be fully exposed, which is not suitable for minimally invasive surgery.

[0006] It should be noted that the above information disclosed in this Background section is only for understanding the background technology of the present application concept, and therefore, it may contain information that does not constitute prior art. Summary of the Invention

[0007] The embodiments of the present disclosure at least provide an epicardial flexible cooling patch for minimally invasive surgery and a method for using the patch.

[0008] In a first aspect, embodiments of the present disclosure provide an epicardial flexible cooling patch for minimally invasive surgery, comprising: a heat absorbing layer having a plurality of heat absorbing capsules therein;

[0009] An adhesive layer is disposed on one side of the microcapsule layer, and the adhesive layer has an application surface on a side away from the heat absorption layer;

[0010] The heat-absorbing capsule comprises an inner cavity, an outer cavity and a diaphragm separating the inner cavity and the outer cavity, wherein the inner cavity and the outer cavity respectively contain a solvent and a heat-absorbing agent;

[0011] The heat absorption layer and the adhesive layer are both flexible layers;

[0012] In addition, the heat absorption layer and the adhesive layer are curled and delivered into the chest cavity through a minimally invasive incision. Then, the heat absorption layer and the adhesive layer are unfolded by surgical forceps, and then the epicardial flexible cooling patch is spread on the surface of the heart through the adhesive layer. Finally, the heat absorption layer is lightly pressed with the tip of the surgical forceps to damage the diaphragm, and the solvent in the inner and outer cavities is mixed and dissolved with the heat absorber, and then the heat on the surface of the heart is absorbed through the adhesive layer.

[0013] In an optional embodiment, the inner cavity contains sterile water;

[0014] The outer cavity contains a mixture of urea and ammonium nitrate, and the ratio of the mixture of urea and ammonium nitrate is 1:1-3:1.

[0015] In an optional embodiment, the diaphragm is made of polylactic acid and is designed to break when the external pressure is greater than or equal to 0.3 MPa.

[0016] In an optional embodiment, the heat absorption layer is mainly composed of an elastic silicone matrix, and the heat absorption capsules are distributed in an array and embedded in the elastic silicone matrix;

[0017] The volume fraction of the heat-absorbing capsules in the heat-absorbing layer is 55-80%.

[0018] In an optional embodiment, the adhesive layer is prepared from a high-water-content polyvinyl alcohol-glycerol composite hydrogel, and its water content is greater than or equal to 70%;

[0019] The adhesion layer is also doped with 2-6 wt% of catechol groups.

[0020] In an optional embodiment, the surface of the adhesion layer has a plurality of densely arranged micro-pillars.

[0021] In an optional embodiment, the epicardial flexible cooling patch further includes a heat insulating layer, which is disposed on a side of the heat absorbing layer away from the adhesive layer.

[0022] In an optional embodiment, the thermal insulation layer is prepared from a PDMS aerogel composite film reinforced with SiO2 nanoparticles.

[0023] In an optional embodiment, the side of the heat-insulating layer away from the heat-absorbing layer further comprises a polytetrafluoroethylene film layer.

[0024] In a second aspect, the present disclosure also provides a method for using the epicardial flexible cooling patch. The method is performed using the epicardial flexible cooling patch described above, including the following steps:

[0025] Step S1, inserting the curled epicardial flexible cooling patch into the chest wall through a 2-3 cm chest wall incision;

[0026] Step S2, unfolding the epicardial flexible cooling patch and spreading it on the heart surface using laparoscopic surgical forceps;

[0027] Step S3, repeating steps S1 and S3 until the cooling range of the heart is completely covered;

[0028] Step S4, squeezing the outer surface of the epicardial flexible cooling patch with the tip of the laparoscopic surgical forceps to rupture the septum and activate the heat-absorbing capsule;

[0029] Step S5: After the epicardial flexible cooling patch finishes absorbing heat, the epicardial flexible cooling patch is removed using laparoscopic surgical forceps;

[0030] Step S6, repeat steps S1-S5 until the operation is completed.

[0031] The beneficial effect of the present invention is that, by designing a flexible heat-absorbing layer and an adhesive layer, the product can be delivered into the chest cavity by rolling it up during minimally invasive surgery, and attached to the surface of the heart through the adhesive layer. By lightly pressing the heat-absorbing layer, the diaphragm is ruptured, and the solvent in the inner and outer cavities is mixed and dissolved with the heat absorbent, thereby absorbing the heat from the surface of the heart through the adhesive layer.

[0032] Other features and advantages of the present invention will be described in the following description, and in part will become apparent from the description, or will be understood by practicing the present invention. The purposes and other advantages of the present invention are realized and obtained in the structures particularly pointed out in the description, claims and drawings.

[0033] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, preferred embodiments are given below and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the specific embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0035] Figure 1 This is a schematic diagram of the first structure of a flexible epicardial cooling patch for minimally invasive surgery provided by an embodiment of the present disclosure;

[0036] Figure 2 A second structural schematic diagram of a flexible epicardial cooling patch for minimally invasive surgery provided by an embodiment of the present disclosure;

[0037] Figure 3 A front view of an adhesive layer provided in an embodiment of the present disclosure;

[0038] Figure 4 A side view of an adhesive layer provided in an embodiment of the present disclosure;

[0039] Figure 5 A schematic structural diagram of a heat absorption layer provided in an embodiment of the present disclosure;

[0040] Figure 6 A cross-sectional view of a heat absorption layer provided in an embodiment of the present disclosure;

[0041] Figure 7 A schematic structural diagram of a heat-insulating layer provided in an embodiment of the present disclosure;

[0042] Figure 8 This is a flow chart of a method for using a flexible epicardial cooling patch for minimally invasive surgery provided by an embodiment of the present disclosure.

[0043] In the picture:

[0044] 1. Heat absorption layer;

[0045] 2. Heat-absorbing capsule; 21. Inner cavity; 22. Outer cavity; 23. Diaphragm;

[0046] 3. Adhesion layer; 31. Application surface; 32. Microcolumns;

[0047] 4. Thermal insulation layer; 41. Polytetrafluoroethylene film layer. DETAILED DESCRIPTION

[0048] To make the objectives, technical solutions, and advantages of the embodiments of the present disclosure more clear, the technical solutions of the embodiments of the present disclosure will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described are only part of the embodiments of the present disclosure, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present disclosure without making any creative efforts shall fall within the scope of protection of the present disclosure.

[0049] Research has found that applying ice chips directly to the heart's surface during CPB surgery can achieve localized myocardial cooling. This method, which is relatively easy to implement during traditional mid-thoracotomy surgery, can significantly reduce myocardial metabolic rate and mitigate ischemia-reperfusion injury. This approach works by lowering the basal metabolic rate of myocardial cells through hypothermia, which, when combined with cardioplegic solutions, can provide effective myocardial protection.

[0050] However, ice chips can easily slip during application and can cause nonspecific hypothermic damage to adjacent tissues, such as the phrenic nerve, diaphragm, and lungs, posing a safety risk. Furthermore, this type of cooling method requires high surgical exposure, often requiring full exposure of the heart, making it unsuitable for the currently widely used minimally invasive approaches.

[0051] Therefore, there is an urgent need to design a flexible epicardial cooling patch for minimally invasive surgery and its use method to solve the technical problems of using ice chips for cooling during the above-mentioned open CPB surgery, which are easy to slip during application and may cause nonspecific hypothermia damage to adjacent tissues such as the phrenic nerve, diaphragm, and lungs. At the same time, ice chip cooling requires the heart to be fully exposed, which is not suitable for minimally invasive surgery.

[0052] The defects in the above solutions are the results obtained by the inventors after practice and careful research. Therefore, the process of discovering the above problems and the solutions proposed by this disclosure for the above problems below should be the contributions made by the inventors to this disclosure during the disclosure process.

[0053] The following describes some embodiments of the present invention in detail with reference to the accompanying drawings. The following embodiments and features thereof may be combined with one another unless they conflict. Furthermore, in the accompanying drawings, the thickness of components may be exaggerated or reduced to effectively illustrate the technical content.

[0054] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0055] Based on the above research, the present disclosure provides a flexible epicardial cooling patch for minimally invasive surgery. Figure 1 The device comprises a heat-absorbing layer 1, an adhesive layer 3, and an insulating layer 4, respectively, located on either side of the heat-absorbing layer 1. The heat-absorbing layer 1, adhesive layer 3, and insulating layer 4 are sequentially connected to form a single unit. This provides targeted, controllable, and continuous cooling protection for the heart during normothermic extracorporeal circulation or beating heart surgery, effectively reducing the risk of myocardial damage caused by ischemia-reperfusion. The flexible epicardial cooling patch is flexible and foldable, and when unfolded, it takes the form of a rectangular sheet, 80 mm long, 60 mm wide, and 3.0 mm thick.

[0056] Reference Figure 2 In at least one embodiment, the heat-absorbing layer 1, the adhesive layer 3, and the heat-insulating layer 4 are all made of flexible materials, so that the epicardial flexible cooling patch itself can be manually rolled up from an extended state to a curled state, so that it can be delivered into the patient's chest cavity through a 2-3 cm chest wall incision during minimally invasive surgery.

[0057] Reference Figure 2 In at least one embodiment, the adhesive layer 3 has an application surface 31 on a side away from the heat absorption layer 1. The adhesive layer 3 contacts the epicardial surface through the application surface 31. Therefore, the application surface 31 is made of an adhesive material. In addition, since the adhesive layer 3 itself does not have a heat absorption function but absorbs heat through the heat absorption layer 1, the adhesive layer 3 must also have good thermal conductivity.

[0058] In at least one embodiment, as an option, the adhesive layer 3 and the application surface 31 are made of a high-water-content polyvinyl alcohol (PVA)-glycerol composite hydrogel material, the water content of which is ≥70%. At the same time, the material can be doped with 2-6wt% catechol groups, preferably 3wt% catechol groups, to improve the adhesion ability in a wet environment. In actual production, the glycerol ratio and cross-linking degree in the hydrogel can be adjusted to slow down the hydration release rate of catechol so that the application surface 31 does not significantly activate the adhesion function within the first 1-2 minutes. Therefore, during operation, it is easy to curl up and unfold after entering the chest cavity, and exhibit adhesion ability after adhering to the epicardial surface, which is convenient for minimally invasive implantation.

[0059] Reference Figure 3 In at least one embodiment, a plurality of micro columns 32 are provided on the surface of the application surface 31. Figure 3 For the sake of convenience, the micro-pillars 32 are magnified to a certain extent. The micro-pillars 32 are grouped in groups of 6 and arranged in a hexagonal pattern around the center. Several groups of micro-pillars 32 are densely arranged, and the distance between the centers of two adjacent groups of micro-pillars 32 is 150 μm. Figure 4 The micro-pillars 32 have a height of 50 μm and a diameter of 50 μm. By providing densely arranged micro-pillars 32, the specific surface area of ​​the application surface 31 and the stability of the application can be increased, while the thermal conductivity is optimized and the thermal resistance is reduced.

[0060] In some embodiments, the micro-pillars 32 are fabricated using a laser etching process, and the height error of the micro-pillars 32 is controlled within ±5 μm.

[0061] Reference Figure 7 In at least one embodiment, in order to prevent the heat absorption layer 1 from absorbing heat away from the heart and causing hypothermia to other nearby non-target organs, such as the lungs, phrenic nerves, and diaphragm, the insulation layer 4 is designed as a heat flow blocking layer to provide insulation. The insulation layer 4 is made of a PDMS (polydimethylsiloxane) aerogel composite film reinforced with SiO2 nanoparticles, and its thermal conductivity is controlled at 0.03 W·m -1 K-1 or less. The thickness of the heat insulating layer 4 is designed to be approximately 500 μm.

[0062] Reference Figure 7In at least one embodiment, the side of the heat-insulating layer 4 away from the heat-absorbing layer 1 further has a polytetrafluoroethylene film layer 41 to further enhance infrared reflection.

[0063] Reference Figure 5 In at least one embodiment, the heat absorption layer 1 has a thickness of approximately 1.0 mm and has a plurality of heat absorption capsules 2 embedded therein. The heat absorption capsules 2 include an inner cavity 21, an outer cavity 22, and a diaphragm 23 separating the inner cavity 21 and the outer cavity 22. The inner cavity 21 and the outer cavity contain a solvent and a heat absorbent, respectively. The diaphragm 23 is used to separate the solvent in the inner cavity 21 and the heat absorbent in the outer cavity to prevent the solvent from immediately contacting the heat absorbent and causing an endothermic reaction.

[0064] Reference Figure 6 In at least one embodiment, the inner cavity 21 contains sterile water, and the outer cavity contains a mixture of urea (CO(NH2)2) and ammonium nitrate (NH4NO3), and the ratio of the mixture of urea and ammonium nitrate is 1:1-3:1. The diameter of the heat-absorbing capsule 2 is 0.8 mm, and the heat-absorbing capsule 2 is arranged in a rectangular array or a honeycomb array. It is worth mentioning that the outside of the heat-absorbing capsule 2 also has a layer of diaphragm 23, that is, the inner and outer sides of the outer cavity are provided with a diaphragm 23 to form a stable cavity and make the heat-absorbing capsule 2 present a double-membrane structure. The main body of the heat-absorbing layer 1 is made of an elastic silicone matrix, and the heat-absorbing capsule 2 is embedded therein, and the volume fraction of the heat-absorbing capsule 2 in the heat-absorbing layer 1 is 55-80%. Preferably, the volume fraction of the heat-absorbing capsule 2 in the heat-absorbing layer 1 is 60%. The diaphragm 23 is made of PLA (polylactic acid), has a thickness of 10μm, and is designed to withstand a pressure of 0.3 MPa. This means that under a local external force ≥ 0.3 MPa, the diaphragm 23 will fracture and shatter, allowing the sterile water in the inner cavity 21 to fuse with the urea and ammonium nitrate mixture in the outer cavity, triggering an endothermic reaction. Specifically, the endothermic capsule 2 can be activated by the operator using curved forceps or a blunt pressure plate to gently press the surface of the patch. This pressure is transmitted to the endothermic capsule 2, which in turn breaks the diaphragm 23 of the endothermic capsule 2, allowing the sterile water to fuse with the urea and ammonium nitrate mixture. The dissolution enthalpy of NH4NO3 is approximately –25.7 kJ / mol, and the dissolution enthalpy of CO(NH2)2 is approximately –14.0 kJ / mol. This results in a heat absorption per unit mass of approximately 300–350 J / g, reducing the myocardial surface temperature to 20–25°C within minutes. A single epicardial flexible cooling patch can store 8–10 kJ of energy per area, and its overall cooling duration can cover the duration of most cardiac surgeries. In actual use, if the duration of surgery exceeds the heat absorption duration of heat absorption layer 1, the patch can be replaced with another one and the heat absorption layer 1 of the new patch can be activated.

[0065] It should be noted that, based on the above design, this epicardial flexible cooling patch releases heat absorption enthalpy through a mixture of water and NH4NO3 / CO(NH2)2 within the capsule, achieving autonomous cooling within the patch without the need for external cooling equipment. The patch is soft and foldable, and can be implanted on the surface of the heart through a minimally invasive incision in the chest wall. It automatically adheres after unfolding during surgery. Subsequently, pressure applied by the surgeon activates the physical reaction within the microcapsule, filling a technical gap that currently prevents existing cryogenic methods or equipment from being used in minimally invasive surgery.

[0066] After activation, this epicardial flexible cooling patch can quickly absorb heat and cool down, with an estimated temperature reduction of 10-15°C in a short period of time. It can maintain the local myocardial temperature below the body cavity temperature during surgery and is suitable for most minimally invasive heart surgeries. The back side is protected by an outer insulation layer 4 and has good overall biocompatibility.

[0067] Related technologies use heat exchange for cooling, which requires an additional heat exchange device. In minimally invasive surgery, operating the heat exchange device requires additional surgical steps and may even require a larger incision, which undoubtedly increases the complexity of the procedure. Our epicardial flexible cooling patch uses a chemical reaction to cool the patient. It only requires curling the product and inserting it into the chest cavity with surgical forceps, eliminating the need for additional equipment and making it simple and safe to operate.

[0068] Furthermore, this product is intended for use inside the body cavity, not on the surface, so there are certain differences in the intended use environment. For example, cooling patches in related technologies work by evaporating water, but the conditions for evaporation are lacking within the body cavity. Therefore, cooling patches designed for direct surface application cannot be used directly in minimally invasive surgery environments, as hydrogels, for example, lack the conditions for evaporation within the body cavity, resulting in low cooling efficiency.

[0069] On the other hand, at least one disclosed embodiment further provides a method for using the epicardial flexible cooling patch, referring to Figure 8 The method is performed using the epicardial flexible cooling patch as described above, comprising the following steps:

[0070] Step S1, inserting the curled epicardial flexible cooling patch into the chest wall through a 2-3 cm chest wall incision;

[0071] Step S2, unfolding the epicardial flexible cooling patch and spreading it on the heart surface using laparoscopic surgical forceps;

[0072] Step S3, repeating steps S1 and S3 until the cooling range of the heart is completely covered;

[0073] Step S4, using the tip of the laparoscopic surgical forceps to squeeze the outer surface of the epicardial flexible cooling patch to rupture the septum 23 to activate the heat-absorbing capsule;

[0074] Step S5: After the epicardial flexible cooling patch finishes absorbing heat, the epicardial flexible cooling patch is removed using laparoscopic surgical forceps;

[0075] Step S6, repeat steps S1-S5 until the operation is completed.

[0076] In the several embodiments provided in this application, it should be understood that the disclosed systems, devices and methods can be implemented in other ways. The device embodiments described above are merely schematic. For example, the division of the units is only a logical function division. There may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. With the above-mentioned ideal embodiment of the present invention as inspiration, through the above-mentioned description, relevant staff can make various changes and modifications without departing from the scope of the technical idea of ​​the disclosed embodiment. The technical scope of the disclosed embodiment is not limited to the contents of the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A flexible epicardial cooling patch for minimally invasive surgery, characterized in that: include: A heat absorbing layer (1) having a plurality of heat absorbing capsules (2) therein; An adhesive layer (3) is provided on one side of the microcapsule layer, and a side of the adhesive layer (3) away from the heat absorption layer (1) has an application surface (31); The heat-absorbing capsule (2) comprises an inner cavity (21), an outer cavity (22), and a diaphragm (23) separating the inner cavity (21) and the outer cavity (22); the inner cavity (21) and the outer cavity (22) respectively contain a solvent and a heat-absorbing agent; The heat absorption layer (1) and the adhesive layer (3) are both flexible layers; Furthermore, the heat absorption layer (1) and the adhesive layer (3) are in a curled state and are delivered into the chest cavity through a minimally invasive incision. Then, the heat absorption layer (1) and the adhesive layer (3) are unfolded by surgical forceps, and then the epicardial flexible cooling patch is spread on the surface of the heart through the adhesive layer (3). Finally, the heat absorption layer (1) is lightly pressed by the surgical forceps to damage the diaphragm (23), so that the solvent in the inner cavity (21) and the outer cavity (22) mixes and dissolves with the heat absorbent, and then absorbs the heat from the surface of the heart through the adhesive layer (3).

2. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The inner cavity (21) contains sterile water; The outer cavity (22) contains a mixture of urea and ammonium nitrate, and the ratio of the mixture of urea and ammonium nitrate is 1:1-3:

1.

3. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The diaphragm (23) is made of polylactic acid and is designed to break when the external pressure is greater than or equal to 0.3 MPa.

4. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The heat absorption layer (1) is mainly composed of an elastic silica gel matrix, and the heat absorption capsules (2) are distributed in an array and embedded in the elastic silica gel matrix; The volume fraction of the heat-absorbing capsule (2) in the heat-absorbing layer (1) is 55-80%.

5. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The adhesive layer (3) is prepared from a high-water-content polyvinyl alcohol-glycerol composite hydrogel, and its water content is greater than or equal to 70%; The adhesion layer (3) is also doped with 2-6 wt% of catechol groups.

6. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The surface of the adhesive layer (3) has a plurality of densely arranged micro columns (32).

7. The epicardial flexible cooling patch for minimally invasive surgery according to claim 1, characterized in that: The epicardium flexible cooling patch further comprises a heat insulating layer (4), which is arranged on a side of the heat absorbing layer (1) away from the adhesive layer (3).

8. The epicardial flexible cooling patch for minimally invasive surgery according to claim 7, characterized in that: The heat-insulating layer (4) is prepared from a PDMS aerogel composite film reinforced with SiO2 nanoparticles.

9. The epicardial flexible cooling patch for minimally invasive surgery according to claim 7, characterized in that: The side of the heat-insulating layer (4) away from the heat-absorbing layer (1) further comprises a polytetrafluoroethylene film layer (41).

10. A method for using an epicardial flexible cooling patch, characterized in that: The method is performed using the epicardial flexible cooling patch according to any one of claims 1 to 9, comprising the following steps: Step S1, inserting the curled epicardial flexible cooling patch into the chest wall through a 2-3 cm chest wall incision; Step S2, unfolding the epicardial flexible cooling patch and spreading it on the heart surface using laparoscopic surgical forceps; Step S3, repeating steps S1 and S3 until the cooling range of the heart is completely covered; Step S4, squeezing the outer surface of the epicardial flexible cooling patch with the tip of the laparoscopic surgical forceps to rupture the septum (23) to activate the heat absorbing capsule (2); Step S5: After the epicardial flexible cooling patch finishes absorbing heat, the epicardial flexible cooling patch is removed using laparoscopic surgical forceps; Step S6, repeat steps S1-S5 until the operation is completed.

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