Water-in-oil type efficient sunscreen lotion as well as preparation method and application thereof

Abstract

The invention relates to a water-in-oil type efficient sunscreen lotion as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The water-in-oil type efficient sunscreen lotion is prepared from 10%-35% of a sun-screening agent, 2%-8% of a film-forming synergist, 15%-40% of grease, 3%-10% of polyhydric alcohols, 0.1%-4% of plant extracts, 2%-8% of an emulsifying agent, 1%-7% of a film-forming agent, 0-5% of auxiliary materials and the balance of water. And the film forming synergist is prepared from isododecane, oxoglutaric acid, disteardimonium hectorite, trimethylsiloxy silicate ester and a sodium hyaluronate cross-linked polymer. The sunscreen lotion disclosed by the invention has a relatively good sunscreen effect.

Description

Technical Field

[0001] The invention relates to a water-in-oil type high-efficiency sunscreen lotion and a preparation method and application thereof, belonging to the technical field of daily chemical products. Background Art

[0002] With increasing awareness of the harmful effects of ultraviolet radiation (UVR) on human skin (such as photoaging, DNA damage, and increased skin cancer risk), sunscreen cosmetics have become a rigid global demand. Traditional sunscreens are categorized by their mechanism: chemical sunscreens (such as avobenzone and octocrylene) absorb UV rays through their conjugated benzene ring structure, but they suffer from poor photostability (for example, avobenzone degrades by 40% in 2 hours) and the risk of allergies; physical sunscreens (such as nano-titanium dioxide and zinc oxide) reflect or scatter UV rays, offering increased safety, but can cause whitening and a heavy feel at high dosages.

[0003] Sunscreen products can be divided into oil-in-water (O / W) or water-in-oil (W / O) systems. The O / W system feels light on the skin but lacks water resistance and durability. The W / O system has excellent water and sweat resistance and a longer-lasting sunscreen effect.

[0004] Currently, oil-in-water sunscreen cosmetics on the market have a single function or uneven functional strength. Therefore, providing an oil-in-water sunscreen lotion with excellent multifunctional strength and good sun protection effect is a technical problem that needs to be solved. Summary of the Invention

[0005] In response to the above technical problems, the present invention provides an oil-in-water type high-efficiency sunscreen lotion and a preparation method and application thereof, belonging to the technical field of daily chemical products.

[0006] On the one hand, the present invention provides a water-in-oil type high-efficiency sunscreen lotion, the raw materials of which include a film-forming synergist, and the film-forming synergist includes isododecane, oxoglutaric acid, disteardimethylammonium hectorite, trimethylsiloxysilicate, and sodium hyaluronate cross-linked polymer.

[0007] Preferably, the amount of the film-forming synergist in the water-in-oil high-efficiency sunscreen lotion is 2-8 wt %.

[0008] Preferably, the weight percentage contents of the film-forming synergist in the sunscreen lotion product are: 1.5-3% isododecane, 0.000001-0.2% oxoglutaric acid, 0.3-1.5% disteardimonium hectorite, 0.2-1.2% trimethylsiloxysilicate, and 0.001-0.8% sodium hyaluronate cross-linked polymer.

[0009] Preferably, the weight percentage contents of the film-forming synergist in the sunscreen lotion product are: 1.8% isododecane, 0.0000045% oxoglutaric acid, 0.45% disteardimonium hectorite, 0.36% trimethylsiloxysilicate, and 0.0054% sodium hyaluronate cross-linked polymer.

[0010] Preferably, the raw materials of the water-in-oil high-efficiency sunscreen lotion further include, by weight percentage, 10-35% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% excipient and the balance water.

[0011] Preferably, the raw materials of the water-in-oil high-efficiency sunscreen lotion further include, by weight percentage, 10-25% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-3% film-forming agent, 0-1.5% excipient and the balance water.

[0012] Preferably, the oil in the water-in-oil type high-efficiency sunscreen lotion includes at least one of synthetic oil, vegetable oil or animal oil.

[0013] Preferably, the sunscreen in the water-in-oil high-efficiency sunscreen lotion includes at least one of a physical sunscreen and a chemical sunscreen.

[0014] Preferably, the polyol in the water-in-oil type high-efficiency sunscreen lotion includes at least one of ethylene glycol, propylene glycol, glycerol, hexylene glycol, sorbitol, and polyethylene glycol.

[0015] Preferably, the auxiliary materials in the water-in-oil type high-efficiency sunscreen lotion include at least one of a preservative, a chelating agent, a fragrance, and a pH adjuster. In addition, the auxiliary materials can also be selected from conventional auxiliary material ingredients in cosmetics according to functional requirements.

[0016] On the other hand, the present invention also provides a method for preparing the water-in-oil type high-efficiency sunscreen lotion, which is characterized by comprising the following steps: (1) heating oil and sunscreen, adding emulsifier, film-forming agent and film-forming synergist, and stirring to obtain an oil phase; (2) heating water, adding polyol and auxiliary materials, and stirring to obtain an aqueous phase; (3) adding the aqueous phase to the oil phase, shearing and emulsifying, then cooling, adding plant extracts, continuing shearing and emulsifying, aging, sterilizing, and filling to obtain the water-in-oil type high-efficiency sunscreen lotion.

[0017] Preferably, in the preparation method, the temperature is heated to 60-85°C in step (1), heated to 60-85°C in step (2), and cooled to 35-50°C in step (3).

[0018] On the other hand, the present invention also provides a sunscreen lotion, which includes: polydimethicone, titanium dioxide (nanoscale), PEG-9 polydimethylsiloxyethyl polydimethicone, hydrated silica, polyglyceryl-3 polydimethylsilyl hydroxyethyl polydimethicone, hydrogenated polydimethicone, aluminum hydroxide, CI 77492, triethoxycaprylylsilane, CI 77491, isododecane, disteardimonium hectorite, trimethylsiloxysilicate, water, 1,2-hexanediol, phenoxyethanol, oxoglutaric acid, disteardimonium hectorite, triethyl citrate, zinc oxide (nanoscale), hydrogenated polydimethicone, aluminum hydroxide, trimethylsiloxysilicate, phenylbenzimidazole sulfonic acid, aminomethyl propanol, sodium chloride, dipotassium glycyrrhizate, EDTA Disodium edta, Butylene Glycol, Squalane, Sodium Hyaluronate (1.2 million molecular weight), Sodium Hyaluronate (200,000 molecular weight), Sodium Hyaluronate (2.1 million molecular weight), Glycerin, Glycereth-26, Sodium Hyaluronate Crosspolymer, Ethylhexyl Methoxycinnamate, BHT, Ethylhexyl Salicylate, Dibutyl Adipate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Octocrylene, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl Triazone, Methyl Methacrylate Crosspolymer, Silica Dimethyl Silylate, Trimethylsiloxysilicate, Silica, Methicone, Phenyl Trimethicone, Cetyl PEG / PPG-10 / 1 Dimethicone, Vinyl Dimethicone / Methicone Silsesquioxane Crosspolymer, PEG-9 Polydimethylsiloxyethyl dimethicone, acrylates / dimethicone copolymer, ascorbyl tetraisopalmitate, tocopheryl acetate, niacinamide, tranexamic acid, aloe barbadensis leaf juice, trehalose, ethylhexylglycerin, bisabolol, ginger root extract, fragrance, hydroxypropyl cyclodextrin, glycyrrhizin, polyquaternium-51, glycerin, camellia sinensis leaf extract, sodium metabisulfite, p-hydroxyacetophenone, scutellaria baicalensis root extract, p-hydroxyacetophenone, ligusticum chuanxiong extract.

[0019] The present invention also provides use of the water-in-oil type high-efficiency sunscreen lotion in the preparation of skin preparations. The amount of the water-in-oil type high-efficiency sunscreen lotion in the skin preparation is 1-50 wt %.

[0020] The beneficial effects of the present invention compared to the prior art are as follows: The water-in-oil high-efficiency sunscreen lotion of the present invention comprises 10-35% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% excipients, and the balance water. The film-forming synergist comprises isododecane, oxoglutaric acid, disteardimonium hectorite, trimethylsiloxysilicate, and sodium hyaluronate cross-linked polymer. The sunscreen lotion prepared by the present invention has good sun protection effect and promising application prospects.

[0021] In addition, after the sunscreen lotion of the present invention is stored at room temperature for 60 days, the particle size of the emulsion changes little, and when stored in high and low temperature environments, the particle size changes little, and the stability is high.

[0022] The present invention uses a combination of cetyl PEG / PPG-10 / 1 polydimethylsiloxane, polyglyceryl-2 diisostearate / IPDI copolymer, and PEG-8 glyceryl isostearate to achieve excellent emulsion stabilization. The cetyl PEG / PPG-10 / 1 polydimethylsiloxane and polyglyceryl-2 diisostearate / IPDI copolymer in the emulsifier system selected for the present invention have a synergistic effect in stabilizing the emulsion, imparting greater stability to the emulsion system.

[0023] Furthermore, the sunscreen lotion obtained by the present invention can inhibit the release of TNF-α and IL-6, inhibit inflammation, has good anti-inflammatory properties, and can reduce acne or skin inflammation.

[0024] The present invention utilizes horseradish extract and tiger lily extract to significantly enhance the anti-inflammatory properties of sunscreen lotions. The horseradish extract and tiger lily extract in the present invention exhibit a synergistic effect in suppressing inflammation. The effect is even greater when the weight ratio of horseradish extract to tiger lily extract is within the range of 1:0.5-1.5.

[0025] The sunscreen lotion prepared by the invention has excellent sun protection effect and an SPF value of above 48.

[0026] The sunscreen lotion of the present invention has excellent performance and effect, simple process and good application prospect. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 : TNF-α and IL-6 levels in sunscreen lotions.

[0028] Figure 2 : Sunscreen lotion SPF value DETAILED DESCRIPTION

[0029] The present invention is further described in detail below with reference to specific embodiments.

[0030] The invention provides a water-in-oil type high-efficiency sunscreen lotion. The raw materials include a film-forming synergist. The film-forming synergist includes isododecane, oxoglutaric acid, disteardimethylammonium hectorite, trimethylsiloxysilicate, and a sodium hyaluronate cross-linked polymer.

[0031] Preferably, the amount of the film-forming synergist in the water-in-oil high-efficiency sunscreen lotion is 2-8 wt %.

[0032] Preferably, the weight percentage contents of the film-forming synergist in the sunscreen lotion product are: 1.5-3% isododecane, 0.000001-0.2% oxoglutaric acid, 0.3-1.5% disteardimonium hectorite, 0.2-1.2% trimethylsiloxysilicate, and 0.001-0.8% sodium hyaluronate cross-linked polymer.

[0033] Preferably, the weight percentage contents of the film-forming synergist in the sunscreen lotion product are: 1.8% isododecane, 0.3% butylene glycol, 0.45% disteardimonium hectorite, 0.36% trimethylsiloxysilicate, and 0.054% sodium hyaluronate cross-linked polymer.

[0034] Preferably, the raw materials of the water-in-oil high-efficiency sunscreen lotion further include, by weight percentage, 10-35% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% excipient and the balance water.

[0035] Preferably, the raw materials of the water-in-oil high-efficiency sunscreen lotion further include, by weight percentage, 10-25% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-3% film-forming agent, 0-1.5% excipient and the balance water.

[0036] Preferably, the oil in the water-in-oil type high-efficiency sunscreen lotion includes at least one of synthetic oil, vegetable oil or animal oil.

[0037] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the oil includes at least one of squalane, jojoba oil, sweet almond oil, macadamia oil, caprylic / capric triglyceride, isopropyl myristate, polydimethylsiloxane, and avocado butter.

[0038] Preferably, the sunscreen in the water-in-oil high-efficiency sunscreen lotion includes at least one of a physical sunscreen and a chemical sunscreen.

[0039] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the sunscreen agent includes at least one of ethylhexyl methoxycinnamate, octocrylene, ethylhexyl salicylate, terephthalylidene dicamphorsulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, phenylbenzimidazole sulfonic acid, and homosalate.

[0040] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the sunscreen comprises 3-6% ethylhexyl methoxycinnamate, 3-6% octocrylene, 1-3.5% ethylhexyl salicylate, 0.5-2.5% phenylbenzimidazole sulfonic acid, and 2.5-7% homosalate.

[0041] Preferably, the polyol in the water-in-oil type high-efficiency sunscreen lotion includes at least one of ethylene glycol, propylene glycol, glycerol, hexylene glycol, sorbitol, and polyethylene glycol.

[0042] Preferably, the auxiliary materials in the water-in-oil type high-efficiency sunscreen lotion include at least one of a preservative, a chelating agent, a fragrance, and a pH adjuster. In addition, the auxiliary materials can also be selected from conventional auxiliary material ingredients in cosmetics according to functional requirements.

[0043] Preferably, in the water-in-oil type high-efficiency sunscreen lotion, the auxiliary materials include 0-0.4% phenoxyethanol, 0-0.4% disodium EDTA and 0-0.7% citric acid.

[0044] Preferably, in the water-in-oil type high-efficiency sunscreen lotion, the plant extract includes at least one of tea extract, horseradish extract, aloe vera extract, and tiger lily extract.

[0045] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the amount of plant extracts used can also be 0.5-4%, including: 0.05-0.5% tea extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe vera extract, and 0.2-1.5% tiger lily extract.

[0046] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the weight ratio of the horseradish extract to the tiger lily extract is 1:0.5-1.5.

[0047] Preferably, in the water-in-oil type high-efficiency sunscreen lotion, the emulsifier includes at least one of cetyl PEG / PPG-10 / 1 polydimethylsiloxane, polyglyceryl-2 diisostearate / IPDI copolymer and PEG-8 glyceryl isostearate.

[0048] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the emulsifier is used in an amount of 3.5-8%, including 1.5-3.2% cetyl PEG / PPG-10 / 1 polydimethylsiloxane, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer and 0.5-1.6% PEG-8 glyceryl isostearate.

[0049] Preferably, in the water-in-oil high-efficiency sunscreen lotion, the film-forming agent includes at least one of acrylic acid (ester) copolymer, VP / hexadecene copolymer, polyvinyl pyrrolidone, vinyl polydimethylsiloxane / polymethylsiloxane silsesquioxane crosspolymer, styrene / acrylic acid (ester) copolymer, and polysilicone-11.

[0050] Preferably, the water-in-oil high-efficiency sunscreen lotion comprises, by weight percentage, 10-35% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.5-4% plant extract, 3.5-8% emulsifier, 1-7% film-forming agent, 0-5% excipient and the balance water; wherein the plant extract comprises: 0.05-0.5% tea extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe vera extract, 0.2-1.5% tiger lily extract; the emulsifier comprises 1.5-3.2% cetyl PEG / PPG-10 / 1 polydimethylsiloxane, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer and 0.5-1.6% PEG-8 glyceryl isostearate.

[0051] Preferably, the water-in-oil high-efficiency sunscreen lotion comprises, by weight percentage, 10-25% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.5-4% plant extract, 3.5-8% emulsifier, 1-3% film-forming agent, 0-1.5% excipient and balance water; wherein the plant extract comprises: 0.05-0.5% tea extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe vera extract, 0.2-1.5% tiger lily extract; the emulsifier comprises 1.5-3.2% cetyl PEG / PPG-10 / 1 polydimethylsiloxane, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer and 0.5-1.6% PEG-8 glyceryl isostearate.

[0052] On the other hand, the present invention also provides a method for preparing the water-in-oil type high-efficiency sunscreen lotion, which is characterized by comprising the following steps: (1) heating oil and sunscreen, adding emulsifier, film-forming agent and film-forming synergist, and stirring to obtain an oil phase; (2) heating water, adding polyol and auxiliary materials, and stirring to obtain an aqueous phase; (3) adding the aqueous phase to the oil phase, shearing and emulsifying, then cooling, adding plant extracts, continuing shearing and emulsifying, aging, sterilizing, and filling to obtain the water-in-oil type high-efficiency sunscreen lotion.

[0053] Preferably, in the preparation method, the temperature is heated to 60-85°C in step (1), heated to 60-85°C in step (2), and cooled to 35-50°C in step (3).

[0054] The present invention also provides use of the water-in-oil type high-efficiency sunscreen lotion in the preparation of skin preparations. The amount of the water-in-oil type high-efficiency sunscreen lotion in the skin preparation is 1-50 wt %.

[0055] The raw material information in the following specific examples is as follows: Disteardimonium hectorite: Zhejiang Huate New Materials Co., Ltd.; Sodium hyaluronate crosspolymer: Wuhan Kemik Biopharmaceutical Technology Co., Ltd.; Squalane: Jinan Zhiheng Zhiyuan Chemical Technology Co., Ltd.; Jojoba oil: Hunan Honghua Jinjia Ecological Environment Engineering Co., Ltd.; Sweet almond oil: Jining Fangyu Chemical Co., Ltd.; Caprylic / capric triglyceride: Wuhan Smack Biotechnology Co., Ltd.; Dimethicone: Wuhan Linsheng Technology Co., Ltd.; Avocado butter: Hubei Xinghengye Technology Co., Ltd.

[0056] Tea extract: Grind green tea leaves, then add 35 wt% ethanol at a material-to-liquid weight ratio of 1:20. Stir and extract at 50°C, 60 rpm for 3 hours, filter, and concentrate the filtrate under reduced pressure at 55°C. Then, freeze-dry the concentrate at -50°C to a water content of 1.90 wt%.

[0057] Horseradish extract: Dried horseradish roots are crushed and then mixed with 25 wt% ethanol at a solid-liquid ratio of 1:25 g / mL. The mixture is heated to 52°C and stirred at 80 rpm for 4 hours. The mixture is then filtered and the filtrate is concentrated under reduced pressure at 55°C. The concentrate is freeze-dried at -55°C to a water content of 2.34 wt%.

[0058] Aloe barbadensis extract: Take aloe barbadensis leaves, peel them, mix the pulp with water in a weight ratio of 1:20, heat to 45°C and stir at 60 rpm for 2 hours, filter, and freeze-dry the filtrate to obtain the extract.

[0059] The extract of Lilium leucophyllum is prepared by crushing dried Lilium leucophyllum bulbs, mixing them with 40 wt% ethanol at a solid-liquid ratio of 1:20 g / mL, heating the mixture to 45°C and stirring at 100 rpm for 5 hours, then filtering the mixture, concentrating the filtrate under reduced pressure at 55°C, and then freeze-drying the concentrate at -45°C to a water content of 2.44 wt%.

[0060] 1. Example 1 Sunscreen 1 Raw material composition, weight percentage: 2.7000045% film-forming synergist, 20% sunscreen, 25% oil, 8% polyol, 2.3% plant extract, 5.5% emulsifier, 3% film-forming agent, 1% excipient and balance water; Film-forming synergists: 1.8% isododecane, 0.0000045% oxoglutaric acid, 0.45% disteardimonium hectorite, 0.36% trimethylsiloxysilicate, 0.09% sodium hyaluronate crosspolymer; Sunscreen: 4% ethylhexyl methoxycinnamate, 5% octocrylene, 3% ethylhexyl salicylate, 2% phenylbenzimidazole sulfonic acid, 6% homosalate; Oils: 3% Squalane, 6% Jojoba Oil, 5% Sweet Almond Oil, 5% Caprylic / Capric Triglyceride, 3% Dimethicone, 3% Shea Butter; Polyols: 3% ethylene glycol, 4% 1,2-propylene glycol, 1% glycerol; Plant extracts: 0.2% tea extract, 1.2% horseradish extract, 0.3% aloe vera extract, 0.6% tiger lily extract; Emulsifiers: 2.3% Cetyl PEG / PPG-10 / 1 Dimethicone, 2.2% Polyglyceryl-2 Diisostearate / IPDI Copolymer, and 1% PEG-8 Glyceryl Isostearate; Film former: 1.5% VP / hexadecene copolymer, 1.5% styrene / acrylic acid (ester) copolymer; Excipients: 0.3% phenoxyethanol, 0.3% disodium EDTA and 0.4% citric acid.

[0061] Preparation method: (1) Add oil raw materials and sunscreen raw materials into a container, heat to 82°C and stir at 80 rpm for 10 minutes, then add emulsifier raw materials, film former raw materials and film-forming synergist raw materials, continue stirring at 120 rpm for 20 minutes to obtain an oil phase; (2) Heat water to 75°C, add polyol raw materials and auxiliary raw materials, and stir at 100 rpm for 20 minutes to obtain an aqueous phase; (3) Add the water phase to the oil phase, shear and emulsify at a speed of 700 rpm for 40 minutes, then cool to 40°C, add the plant extract, maintain the speed and continue shearing and emulsifying for 10 minutes, let it stand at room temperature for 30 minutes, sterilize, and fill to obtain the oil-in-water type high-efficiency sunscreen lotion.

[0062] Sunscreen 2 Raw material composition, weight percentage: 3.0002% film-forming synergist, 20.3% sunscreen, 24% oil, 8.5% polyol, 2.32% plant extract, 5.45% emulsifier, 2.8% film-forming agent, 1.1% excipient and balance water; Film-forming synergists: 2% isododecane, 0.0002% oxoglutaric acid, 0.4% disteardimonium hectorite, 0.5% trimethylsiloxysilicate, 0.1% sodium hyaluronate crosspolymer; Sunscreen: 5% ethylhexyl methoxycinnamate, 4.5% octocrylene, 3.5% ethylhexyl salicylate, 2.5% phenylbenzimidazole sulfonic acid, 4.8% homosalate; Oils: 5% Squalane, 3% Jojoba Oil, 7% Sweet Almond Oil, 2% Caprylic / Capric Triglyceride, 2.5% Dimethicone, 4.5% Shea Butter; Polyols: 2% ethylene glycol, 6% 1,2-propylene glycol, 0.5% glycerol; Plant extracts: 0.25% tea extract, 0.72% horseradish extract, 0.27% aloe vera extract, 1.08% tiger lily extract; Emulsifiers: 1.5% Cetyl PEG / PPG-10 / 1 Dimethicone, 3% Polyglyceryl-2 Diisostearate / IPDI Copolymer, and 0.95% PEG-8 Glyceryl Isostearate; Film former: 1.2% VP / hexadecene copolymer, 1.6% styrene / acrylic acid (ester) copolymer; Excipients: 0.35% phenoxyethanol, 0.35% disodium EDTA and 0.4% citric acid.

[0063] Preparation method: (1) Add oil raw materials and sunscreen raw materials into a container, heat to 80°C and stir at 100 rpm for 12 minutes, then add emulsifier raw materials, film-forming agent raw materials and film-forming synergist raw materials, continue stirring at 130 rpm for 25 minutes to obtain an oil phase; (2) Heat water to 75°C, add polyol raw materials and auxiliary raw materials, and stir at 120 rpm for 25 minutes to obtain an aqueous phase; (3) Add the water phase to the oil phase, shear and emulsify at a speed of 750 rpm for 45 minutes, then cool to 38°C, add the plant extract, maintain the speed and continue shearing and emulsifying for 12 minutes, let it stand at room temperature for 25 minutes, sterilize, and fill to obtain the oil-in-water type high-efficiency sunscreen lotion.

[0064] Sunscreen 3 The difference from sunscreen lotion 1 is the type of emulsifier. Span-20 is used to replace the emulsifier in the sunscreen lotion at a dosage of 5.5%.

[0065] Sunscreen 4 The difference from Sunscreen Lotion 1 is the emulsifier, which is composed of 4.5% cetyl PEG / PPG-10 / 1 polydimethylsiloxane and 1% PEG-8 glyceryl isostearate.

[0066] Sunscreen 5 The difference from Sunscreen Lotion 1 is the emulsifier, which is composed of 4.5% polyglyceryl-2 diisostearate / IPDI copolymer and 1% PEG-8 glyceryl isostearate.

[0067] Sunscreen 6 The difference from Sunscreen Lotion 1 is the composition of plant extracts. It does not contain horseradish extract and tiger lily extract. The composition of plant extracts is: 0.2% tea extract and 0.3% aloe vera extract.

[0068] Sunscreen 7 The difference from sunscreen lotion 1 is the composition of plant extracts, which are: 0.2% tea extract, 1.8% horseradish extract, and 0.3% aloe vera extract.

[0069] Sunscreen 8 The difference from sunscreen lotion 1 is the composition of plant extracts, which are: 0.2% tea extract, 0.3% aloe vera extract, and 1.8% tiger lily extract.

[0070] Sunscreen 9 The difference from sunscreen lotion 1 is the different ratios of horseradish extract and tiger lily extract. The composition of the plant extracts is: 0.2% tea extract, 1.6% horseradish extract, 0.3% aloe vera extract, 0.2% tiger lily extract, horseradish extract: tiger lily extract = 1:0.125.

[0071] Sunscreen 10 The difference from sunscreen lotion 1 is the different ratios of horseradish extract and tiger lily extract. The composition of plant extracts is: 0.2% tea extract, 0.36% horseradish extract, 0.3% aloe vera extract, 1.44% tiger lily extract, horseradish extract: tiger lily extract = 1:4.

[0072] 2. Example 2 The above emulsions were tested.

[0073] 1. Stability The average particle size of the emulsion prepared above was measured and recorded as D0; the average particle size of the emulsion prepared above was measured after being placed at room temperature for 60 days and recorded as D1; ​​the average particle size of the emulsion prepared above was measured after being placed in a 50°C environment for 60 days and recorded as D2; the average particle size of the emulsion prepared above was measured after being placed in a 4°C environment for 60 days and recorded as D3. The changes in D1, D2, and D3 compared to D0 were then calculated and recorded as K1, K2, and K3, respectively. Four parallel groups were set up and the average values ​​were taken. The results are shown in Table 1. Among them, the smaller the change in particle size, the better the stability of the system.

[0074] Table 1: Stability test

[0075] Combined with the test results in Table 1, it can be seen that after 60 days of storage at room temperature, the particle size of the emulsion changes little, and the particle size changes are also small when stored in high and low temperature environments; thus, it can be seen that the sunscreen lotion prepared by the present invention has high stability.

[0076] From the comparison between sunscreens 1 and 3, it can be seen that the present invention uses a combination system of cetyl PEG / PPG-10 / 1 polydimethylsiloxane, polyglyceryl-2 diisostearate / IPDI copolymer and PEG-8 glyceryl isostearate, which can achieve excellent and stable emulsion performance.

[0077] Combined with the tests on sunscreens 1, 4-5, it can be seen that when one of cetyl PEG / PPG-10 / 1 polydimethylsiloxane and polyglyceryl-2 diisostearate / IPDI copolymer is used in combination with PEG-8 glyceryl isostearate in sunscreens 4-5, the emulsion stability is not as good as that of sunscreen 1. This shows that in the emulsifier system selected by the present invention, the use of cetyl PEG / PPG-10 / 1 polydimethylsiloxane and polyglyceryl-2 diisostearate / IPDI copolymer has a synergistic effect in stabilizing the emulsion, giving the emulsion system better stability.

[0078] 2. Anti-inflammatory test The sunscreen lotion prepared above was subjected to an anti-inflammatory test, wherein the better the effect of inhibiting the release of TNF-α and IL-6, the better the anti-inflammatory effect.

[0079] Consumables: RAW264.7 cells, 24-well plates, ELISA kit.

[0080] Test drugs: LPS, DMEM medium, and the above-mentioned sunscreen lotion.

[0081] Testing process: RAW264.7 cells were cultured at a density of 1.20×10 5 Cells were inoculated into 24-well plates with 0.5 mL of culture medium per well, and cultured in a 37°C, 5% CO2 incubator for 24 hours. Groups were then administered medication: the sunscreen group received LPS (to a concentration of 1.1 μg / mL) plus sunscreen (to a concentration of 0.012 wt%), while the model group received LPS (to a concentration of 1.1 μg / mL). The blank group received no treatment, and three parallel groups were set up for each group. After a further 24 hours of incubation at 37°C, 5% CO2, the supernatants were collected from the plates and assayed for TNF-α and IL-6 levels using the procedure described in the kit instructions. The results are shown in Table 2. In Table 2, ΔTNF-α / pg / mL and ΔIL-6 / pg / mL represent the reduction compared to the values ​​in the model group.

[0082] Table 2: Anti-inflammatory test

[0083] As can be seen from the test results in Table 2, the sunscreen lotion obtained by the present invention can inhibit the release of TNF-α and IL-6, inhibit inflammation, has good anti-inflammatory properties, and can reduce acne or skin inflammation.

[0084] By comparing sunscreens 1 and 6, it can be seen that after omitting the horseradish extract and tiger lily extract, the effect of sunscreen 6 in inhibiting the release of TNF-α and IL-6 is significantly reduced compared to that of sunscreen 1. Therefore, it can be seen that the use of horseradish extract and tiger lily extract in the present invention can significantly improve the anti-inflammatory properties of sunscreen. When one of the horseradish extract and tiger lily extract is used in sunscreens 7-8 and the amount used is consistent with the total amount of the two in sunscreen 1, the anti-inflammatory effect obtained is lower than that of sunscreen 1. It can be seen that the horseradish extract and tiger lily extract specifically prepared by the present invention have a synergistic relationship in inhibiting the inflammatory effect. Furthermore, the effect of sunscreens 9-10, in which the ratio of the two is changed, is lower than that of sunscreens 1-2. That is to say, in the system of the present invention, the effect of the horseradish extract and tiger lily extract in the weight ratio range of 1:0.5-1.5 is better.

[0085] 3. Sunscreen test The sunscreen lotion was tested for its sun protection effect. The larger the SPF value, the better the sun protection effect.

[0086] Consumables: SPF-290S sun protection index analyzer, Optometrics, USA; PMMA plate.

[0087] Test procedure: At 20±2°C and 50±5% relative humidity, use a disposable syringe to take the test sample and evenly apply it to a PMMA plate. After 20 minutes, perform a transmittance scan at 290-400nm. The SPF value of the sample is calculated using the software. Each group is tested in parallel three times, and the average value is taken. The results are shown in Table 3.

[0088] Table 3: Sunscreen test

[0089] From the test results in Table 3, it can be seen that the sunscreen lotion prepared by the present invention has excellent sun protection effect, with an SPF value of more than 48.

Claims

1. A water-in-oil type high-efficiency sunscreen lotion, characterized in that: The raw materials include film-forming synergists, which include isododecane, oxoglutaric acid, disteardimethylammonium hectorite, trimethylsiloxysilicate, and sodium hyaluronate cross-linked polymer.

2. The water-in-oil high-efficiency sunscreen lotion according to claim 1, characterized in that: The dosage of film-forming synergist in oil-in-water type high-efficiency sunscreen lotion is 2-8wt%.

3. The water-in-oil high-efficiency sunscreen lotion according to claim 2, characterized in that: According to weight percentage, the raw materials also include 10-35% sunscreen, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% auxiliary materials and the balance water.

4. The water-in-oil high-efficiency sunscreen lotion according to claim 3, characterized in that: The oil comprises at least one of synthetic oil, vegetable oil or animal oil.

5. The water-in-oil high-efficiency sunscreen lotion according to claim 3, characterized in that: The sunscreen includes at least one of a physical sunscreen and a chemical sunscreen.

6. The water-in-oil high-efficiency sunscreen lotion according to claim 3, characterized in that: The polyol includes at least one of ethylene glycol, propylene glycol, glycerin, hexylene glycol, sorbitol, and polyethylene glycol.

7. The water-in-oil high-efficiency sunscreen lotion according to claim 3, characterized in that: The auxiliary materials include at least one of preservatives, chelating agents, flavors, and pH regulators.

8. A method for preparing a water-in-oil high-efficiency sunscreen lotion according to any one of claims 1 to 7, characterized in that: The method comprises the following steps: (1) heating oil and sunscreen, adding emulsifier, film former and film-forming synergist, stirring to obtain oil phase; (2) heating water, adding polyol and auxiliary materials, stirring to obtain water phase; (3) adding water phase to oil phase, shearing and emulsifying, then cooling, adding plant extract, continuing shearing and emulsifying, aging, sterilizing, and filling to obtain the water-in-oil type high-efficiency sunscreen lotion.

9. The preparation method according to claim 8, characterized in that In step (1), the mixture is heated to 60-85°C, and in step (2), the mixture is heated to 60-85°C; and in step (3), the mixture is cooled to 35-50°C.

10. Use of the water-in-oil high-efficiency sunscreen lotion according to any one of claims 1 to 7 or the water-in-oil high-efficiency sunscreen lotion prepared by the preparation method according to any one of claims 8 to 9 in preparing a skin preparation, characterized in that: The amount of the water-in-oil high-efficiency sunscreen lotion in the skin preparation is 1-50 wt %.

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