Assisted reproductive semen treatment device matched with different insemination modes

Abstract

The invention discloses an auxiliary reproductive semen treatment device matched with different insemination modes, which comprises a box body with an openable box door, a heating treatment table is arranged at the center of the bottom in the box body, and a treatment plate is placed on the heating treatment table; a control box is arranged at the top, a control circuit board is arranged in the control box, a heat dissipation plate and a display screen are arranged, and keys and knobs are arranged on the two sides; the back of the box is provided with a power interface. Through modular design, the device is compatible with semen treatment of various insemination modes such as IVF, ICSI and IUI; the first processing plate (transverse groove method) and the second processing plate (screen method) are used for screening sperms, through natural movement ability, form and thermotaxis guidance, mechanical damage is reduced, sperm motility is improved, sperm DNA fragment rate is reduced, and therefore ovum fertilization rate, embryo quality and pregnancy outcome are expected to be improved.

Description

Technical Field

[0001] The present invention relates to the field of assisted reproductive technology, and more particularly, to an assisted reproductive semen processing device that matches different insemination methods. Background Art

[0002] In assisted reproduction, semen processing is a critical step in achieving pregnancy. Semen processing requirements vary significantly between different insemination methods, including conventional in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and intrauterine insemination (IUI). For example, IUI requires processed semen with high sperm motility and concentration; fertilization-embryo transfer requires optimized semen processing to obtain high-quality sperm; and intracytoplasmic sperm injection requires screening for individual sperm with normal morphology and good motility.

[0003] At present, there are many shortcomings in the existing semen processing devices. Most devices have a single function and cannot flexibly match the diverse needs of various insemination methods. The sperm pretreatment methods currently accepted by hospitals and research institutes include simple sperm washing, swim-up method, density gradient centrifugation, etc., which all include centrifugation, dilution and then centrifugation enrichment operations. The shear force generated by the centrifugation process may cause cell membrane perforation or rupture, reducing sperm vitality; at the same time, the centrifugation process will induce oxidative stress response, resulting in an increase in sperm DNA fragmentation rate (DFI), affecting fertilization ability and embryo quality. Therefore, there is an urgent need to design an assisted reproductive semen processing device that can match different insemination methods and cause less damage to sperm. Summary of the Invention

[0004] The present invention aims to provide a semen processing device for assisted reproduction that is compatible with different insemination methods. This device can adapt to different insemination methods, avoid operations that can easily damage sperm during semen sample processing, and select sperm based on their morphology and motility. Furthermore, it can utilize thermotropism to optimize the screening process and achieve sperm enrichment.

[0005] The above technical objectives of the present invention are achieved through the following technical solutions: an assisted reproductive semen processing device that matches different insemination methods, including a box body, the front of the box body is provided with an openable door; the interior of the box body is provided with a processing table in the middle of the bottom, the processing table is provided with a heating component, and a processing plate is placed on the processing table; the interior of the box body is provided with a control box at the top, the back of the control box passes through the back of the box body and a heat sink is provided on the back of the control box, and a control circuit board is provided in the control box; the top of the box body is provided with a display screen and function buttons and function knobs are provided on both sides; the back of the box body is provided with a power interface.

[0006] The present invention is further configured as follows: an observation window 1 is provided on the box door, and the observation window 1 is closed by a sealing plate made of a transparent and light-transmitting material; the observation window 1 is provided with a slidable movable baffle 1 made of an opaque material on the outside of the sealing plate; an observation window 2 is provided on the top of the box body, and the observation window 2 is closed by a sealing plate made of a transparent and light-transmitting material; the observation window 2 is provided with a slidable movable baffle 2 made of an opaque material on the outside of the sealing plate.

[0007] The present invention is further configured as follows: a storage drawer is provided at the bottom of the box, the storage drawer is used to place the processing board; the processing table is arranged in the middle of the top of the storage drawer; and ultraviolet lamps are provided on two opposite sides of the box.

[0008] The present invention is further configured as follows: the processing plate is processing plate one, and the processing plate one is provided with a lofting groove, a collecting groove and a horizontal transverse groove; the lofting groove is arranged close to one side of the processing plate one, and is connected to the sampling groove through the transverse groove; the processing plate one is provided with a mounting column one at the bottom close to the front and the back, and the processing plate one is provided with a carrying handle one at the top close to the front and the back; the length of the transverse groove is 10mm-15mm, 25mm-35mm or 45mm-55mm.

[0009] It is further configured that the length of the transverse groove is 15 mm, 25 mm or 45 mm.

[0010] The present invention is further configured as follows: the processing plate is processing plate two, the processing plate two is provided with a processing trough and a screening frame, the processing trough includes a sampling area, a primary screening area, a secondary screening area and a collection area arranged in sequence; the sampling area, the primary screening area, the secondary screening area and the collection area are symmetrically provided with limit seats on both sides above the junction for placing the screening frame; the screening frame includes a circular screening frame, a screening net is provided in the middle of the screening frame, and a handle is provided on the top of the screening frame; the processing plate two is provided with two mounting columns at the bottom near the front and the back, and the processing plate two is provided with two carrying handles at the top near the front and the back.

[0011] It is further configured as follows: the screening mesh is a polycarbonate membrane with different pore sizes and a thickness between 0.2mm and 0.4mm; the pore size of the screening mesh of the screening frame between the sample area and the primary screening area is 20um; the pore size of the screening mesh of the screening frame between the primary screening area and the second screening area is 10um; the pore size of the screening mesh of the screening frame between the second screening area and the collection area is 20um.

[0012] The present invention is further configured as follows: the processing table is provided with a placement groove in the middle of the top, and positioning holes are provided on both sides of the placement groove near the edges; the processing plate is positioned and placed on the top of the processing table through the positioning holes and the placement groove; a heating groove is provided at the bottom of the placement groove for installing a heating component, a heat-conducting cover is provided on the top of the heating groove, and a plurality of temperature sensors are provided near the heating groove; the heating component includes a heating plate, a heating tube and a heat insulation plate, and the heat insulation plate is provided at both ends of the heating tube.

[0013] It is further configured as follows: the number of the heating disks is 4; the 4 heating disks are respectively located below the sample setting area, the primary screening area, the secondary screening area and the collection area; a heating tube is provided between two adjacent heating disks.

[0014] It is further configured as follows: the number of the heating disks is 4; one heating disk is located below the sample slot, and the other three heating disks are located below the collecting slot when the transverse slots are of different lengths; a heating tube is provided between two adjacent heating disks.

[0015] It is further configured as follows: when the three heating plates are located at the bottom of the collecting tank in transverse grooves of different lengths, and when the three heating plates are located at the bottom of the primary screening area, the second screening area and the collecting area respectively, the heating plates in the two configurations are configured in the same position in the heating tank.

[0016] In summary, the present invention has the following beneficial effects:

[0017] 1. Multi-scenario adaptation: Through the modular design of processing board 1 (processing board with different transverse groove lengths) and processing board 2 (multiple screening frames), it is compatible with the semen processing needs of various insemination methods such as IVF, ICSI, and IUI.

[0018] 2. Non-damage screening: Abandoning centrifugation, screening is performed through the natural motility and morphology of sperm, combined with thermotaxis guidance to reduce mechanical damage, ultimately improving the motility of treated sperm and reducing the DNA fragmentation rate, thereby potentially improving the fertilization rate of eggs, embryo quality and pregnancy outcomes.

[0019] 3. Precise temperature control: The heating component is linked with the temperature sensor to achieve precise temperature control of the processing area, simulate the in vivo environment, and improve sperm activity and screening efficiency.

[0020] 4. Easy to operate: The design of observation window, movable baffle, storage drawer, etc. takes into account both visualization needs and contamination control. The handle and positioning structure facilitate the quick replacement of processing plates, which is in line with clinical operation habits. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 2 is a front view of a semen processing device for assisted reproduction according to an embodiment of the present invention;

[0022] Figure 2 2 is a schematic diagram of the back of the assisted reproductive semen processing device according to an embodiment of the present invention;

[0023] Figure 3 This is a diagram of the internal structure of the assisted reproductive semen processing device according to an embodiment of the present invention;

[0024] Figure 4 is a schematic diagram of a processing station in an embodiment of the present invention;

[0025] Figure 5 This is a structural diagram of a processing station in an embodiment of the present invention;

[0026] Figure 6 This is a structural diagram of a processing board 1 in an embodiment of the present invention;

[0027] Figure 7 This is a comparison chart of the results of treating semen by Example 1 of the present invention and density gradient centrifugation;

[0028] Figure 8 This is a structural diagram of the processing board 2 in the second embodiment of the present invention;

[0029] Figure 9 1 is a comparison chart of the results of treating semen by Example 2 of the present invention and density gradient centrifugation.

[0030] In the figure: 1. Box body; 2. Box door; 3. Observation window 1; 4. Movable baffle 1; 5. Display screen; 6. Function buttons; 7. Function knob; 8. Observation window 2; 9. Movable baffle 2; 10. Power interface; 11. Heat sink; 12. Storage drawer; 13. UV lamp; 14. Control box; 15. Processing station; 16. Processing board 1; 17. Processing board 2; 18. Labeling area; 151. Placement slot; 152. Positioning hole; 153. Heat-conducting cover; 154. Temperature sensor; 155, heating tank; 156, heating plate; 157, heating tube; 158, insulation board; 161, setting out tank; 162, collecting tank; 163, horizontal tank; 164, one handle; 165, one mounting column; 171, setting out area; 172, primary screening area; 173, secondary screening area; 174, collecting area; 175, two mounting columns; 176, screening rack; 177, screening net; 178, handle; 179, limit card seat; 1710, two handles. DETAILED DESCRIPTION

[0031] The following is combined with Figure 1-9 The present invention is described in further detail.

[0032] Example 1: An assisted reproductive semen processing device that matches different insemination methods, such as Figure 1-Figure 7As shown, the box includes a housing 1, with an openable door 2 on the front. Inside the box 1, a processing table 15 is provided in the middle of the bottom. The processing table 15 is equipped with a heating assembly, and a processing board is placed on the processing table 15. Inside the box 1, a control box 14 is provided at the top. The back of the control box 14 extends through the back of the box 1 and is provided with a heat sink 11. The control box 14 contains a control circuit board. The top of the box 1 is provided with a display screen 5, and function buttons 6 and a function knob 7 are provided on both sides. The back of the box 1 is provided with a power supply port 10. The door 2 is provided with an observation window 3, which is sealed with a sealing plate made of a transparent and light-transmitting material. A movable baffle 4 made of an opaque material is provided on the outside of the sealing plate. The top of the box 1 is provided with an observation window 8, which is sealed with a sealing plate made of a transparent and light-transmitting material. A movable baffle 9 made of an opaque material is provided on the outside of the sealing plate. A storage drawer 12 is provided at the bottom of the box body 1 for placing the processing board; a processing table 15 is provided at the top middle of the storage drawer 12; and ultraviolet lamps 13 are provided on opposite sides of the box body 1.

[0033] The control circuit board in the control box 14 can coordinate the operation of the display screen 5, function buttons 6, function knobs 7 and heating components to achieve temperature parameter setting and processing flow control; the heat sink 11 ensures the stable operation of the internal components of the control box 14; the power interface 10 provides power support for the device to form an integrated semen processing platform. Observation window 1 3 and observation window 2 8 use light-transmitting sealing plates, which can observe the semen processing status in real time without opening the box door 2 to avoid external contamination; movable baffle 1 4 and movable baffle 2 9 can block light when necessary to prevent light from interfering with sperm activity. It can prevent ultraviolet light leakage during ultraviolet disinfection. The storage drawer 12 provides storage space for the processing board, which is convenient for quick replacement of processing boards with different functions; the ultraviolet lamp 13 can sterilize the inside of the box 1 before and after treatment to ensure a sterile environment and reduce the risk of sample contamination.

[0034] The processing plate is processing plate 16, which is equipped with a staking out slot 161, a collecting slot 162, and a horizontal transverse slot 163. Staking out slot 161 is located near one side of processing plate 16 and is connected to the sampling slot via transverse slot 163. Processing plate 16 is equipped with mounting posts 165 at the bottom near the front and back, and handles 164 at the top near the front and back. The length of transverse slot 163 is 10mm-15mm, 25mm-35mm, or 45mm-55mm. Specifically, the length of transverse slot 163 is 15mm, 25mm, or 45mm.

[0035] The placement groove 161 is used to hold the original semen sample, while the transverse groove 163 serves as a channel for sperm movement. Its length corresponds to the required sperm movement distance for different insemination methods, thereby obtaining sperm that is suitable for the specific method. After 30-60 minutes of processing, the shortest transverse groove 163 yields the highest number of sperm, meeting the sperm quantity requirements for IUI and conventional IVF for patients with mild oligozoospermia and asthenozoospermia. The medium-length transverse groove 163 yields a moderate number of sperm, meeting the sperm quantity requirements for conventional IVF for patients with normal semen examinations. The shortest transverse groove 163 eliminates the risk of some low-quality sperm migrating to the collection point due to diffusion over short distances, resulting in a more effective screening effect. The longest transverse groove 163, which most closely matches the physiological length of the female reproductive tract, yields a higher proportion of sperm with normal migration ability (from the cervical os to the sperm-egg binding site in the ampulla of the fallopian tube). Although long-distance screening also leads to a sharp drop in sperm concentration, it is sufficient to meet the sperm quantity requirements for ICSI insemination. Processing plate 16 with transverse grooves 163 of varying lengths can meet the needs of semen processing for IVF, ICSI, and IUI, where only one insemination method is required. Mounting posts 165 engage with positioning holes 152 of processing table 15 to ensure stable mounting of the processing plate. Handle 164 facilitates handling and replacement of the processing plate. The optimal transverse groove 163 length has been experimentally verified to effectively distinguish sperm of varying motility levels, improving screening efficiency.

[0036] The processing table 15 is provided with a placement groove 151 in the middle of the top, and positioning holes 152 are provided on both sides of the placement groove 151 near the edges; the processing plate is positioned on the top of the processing table 15 through the positioning holes 152 and the placement groove 151; a heating groove 155 is provided at the bottom of the placement groove 151 for installing a heating component, and a heat-conducting cover plate 153 is provided on the top of the heating groove 155. A number of temperature sensors 154 are provided near the heating groove 155 of the placement groove 151; the heating component includes a heating plate 156, a heating tube 157 and an insulation board 158, and the insulation board 158 is arranged at both ends of the heating tube 157.

[0037] The placement slot 151 and the positioning hole 152 cooperate to achieve precise positioning of the processing plate; the heating plate 156 and the heating tube 157 in the heating slot 155 provide heat sources, and the heat-conducting cover 153 evenly conducts heat; the temperature sensor 154 monitors the temperature of the processing area in real time, and feeds back to the control circuit board to realize temperature closed-loop control, ensuring a temperature accuracy of ±0.5°C, simulating the temperature environment in the body (about 37°C), and using the thermotaxis of sperm to guide it to move to a suitable temperature area to assist in screening.

[0038] There are four heating disks 156; one heating disk 156 is located below the sample slot 161, and the other three heating disks 156 are located below the collection slot 162 at different lengths of transverse slots 163. A heating tube 157 is provided between two adjacent heating disks 156. Regarding the structure of processing plate 16, the heating disk 156 below the sample slot 161 maintains the sample temperature at 32°C. The heating disks 156 below the collection slots 162 corresponding to transverse slots 163 of different lengths can be set to a specific temperature. For example, to maintain a certain temperature difference with the sample slot 161, all heating disks 156 below the collection slots 162 of different transverse slots 163 are used to maintain the temperature of the collection slots 162 at 37°C. The heating tube 157 is used to maintain a stable temperature between the heating disks 156, using the temperature difference to guide sperm of different motility to choose the corresponding movement path, thereby achieving motility classification and screening.

[0039] Furthermore, 3-4 semen samples with good quality (forward motility sperm rate>50%) and semen volume ≥4ml were selected. Each semen sample was divided into 4 equal volumes and processed by density gradient centrifugation and transverse troughs of 15mm, 25mm and 45mm respectively. We found that the recovery rate of the density gradient centrifugation method commonly used in clinical practice was about 40%, while the recovery rate of the transverse trough method was significantly lower than that of the density gradient centrifugation method. The recovery rate decreased significantly with the increase of the transverse trough length ( Figure 7 A); however, the forward motility sperm rate (PR) of semen treated with 15 mm transverse groove was close to that of density gradient centrifugation, while the PR of semen treated with 25 mm transverse groove and 45 mm transverse groove was significantly higher than that of density gradient centrifugation ( Figure 7 B); Similarly, the non-motile sperm rate (NP) and sperm DNA fragmentation rate (DFI) of semen treated with 15mm transverse groove were close to those of density gradient centrifugation, while the NP and DFI of semen treated with 25mm transverse groove and 45mm transverse groove were significantly lower than those of density gradient centrifugation ( Figure 7 C and D). In summary, although the recovery rate of sperm treated with the horizontal channel method was significantly lower than that of conventional density gradient centrifugation, the PR and DFI of the treated sperm were significantly improved. This suggests that sperm treated with the horizontal channel method have improved motility and significantly reduced DNA fragmentation, potentially improving oocyte fertilization rate, embryo quality, and pregnancy outcomes.

[0040] Example 2: Figure 8-Figure 9As shown, it is basically the same as the embodiment 1, except that the processing plate is the processing plate 17, the processing plate 17 is provided with a processing tank and a screening frame, the processing tank includes a sampling area 171, a primary screening area 172, a secondary screening area 173 and a collection area 174 arranged in sequence; the sampling area 171, the primary screening area 172, the secondary screening area 173 and the collection area 174 are symmetrically provided with limit seats 179 on both sides above the junction for placing the screening frame; the screening frame includes a circular screening frame 176, a screening net 177 is provided in the middle of the screening frame 176, and a handle 178 is provided on the top of the screening frame 176; the processing plate 17 is provided with a second mounting column 175 at the bottom near the front and the back, and the processing plate 17 is provided with a second handle 1710 at the top near the front and the back. The screening mesh 177 is a polycarbonate membrane with different pore sizes and thicknesses ranging from 0.2mm to 0.4mm; the pore size of the screening mesh 177 of the screening frame between the sampling area 171 and the primary screening area 172 is 20um; the pore size of the screening mesh 177 of the screening frame between the primary screening area 172 and the second screening area 173 is 10um; the pore size of the screening mesh 177 of the screening frame between the second screening area 173 and the collection area 174 is 20um.

[0041] The zoning design of the processing tank enables multi-level screening of sperm. The sample placement area 171, the primary selection area, the optimization area, and the enrichment area respectively house pre-processed samples, sperm culture fluid, sperm culture fluid, and sperm collection fluid. After placing the sample in the sample placement area 171, the vast majority of sperm with forward motility can pass through the first screening frame and enter the primary screening area 172; sperm with poor motility and circular motion are retained in the sample placement area 171. This reduces the risk of inferior sperm clogging the subsequent screening frames. The screening frame between the primary screening area 172 and the secondary screening area 173 selects the better sperm for entry into the secondary screening area 173. The screening frame between the secondary screening area 173 and the collection area 174 further selects the best sperm and collects them in the collection area 174. The limiter bracket 179 secures the screening frame to prevent displacement during the screening process. The design of the second handle 1710 and the second mounting post 175 facilitates the installation and removal of the processing plate 17. Processing plate 2 17 can simultaneously meet the needs of semen processing for multiple insemination methods, including IVF, ICSI, and IUI. The polycarbonate membrane combines light transmittance and mechanical strength, facilitating observation of sperm motility. The graded aperture design (20μm → 10μm → 20μm) relies on the difference in motility between high-quality and low-quality sperm for preliminary screening, selecting sperm based on motility and size. A small-aperture screening mesh 177 blocks abnormal sperm, while a large-aperture mesh allows qualified sperm to enter the collection area 174, achieving non-invasive screening based on sperm morphology. Ultimately, by screening the largest number of sperm in the primary screening area, the sperm count requirements for conventional IVF for IUI and patients with mild oligospermia and asthenozoospermia are met. By obtaining a moderate number of sperm in the secondary screening area, the sperm count requirements for conventional IVF for patients with normal semen examinations are met. By obtaining a higher proportion of sperm with normal motility in the collection area, the sperm count requirements for ICSI are met.

[0042] There are four heating trays 156, located below the sample area 171, primary screening area 172, secondary screening area 173, and collection area 174, respectively. A heating tube 157 is installed between adjacent heating trays 156. In accordance with the zoning design of processing plate 2 17, a separate heating tray 156 is installed below each functional area, allowing for temperature control in different areas (e.g., 32°C in the sample area 171, 37°C in the primary screening area 172, 37°C in the secondary screening area 173, and 37°C in the collection area 174). This creates a temperature gradient, guiding sperm toward the optimal temperature zone (collection area 174) and enhancing the screening effect.

[0043] Furthermore, 3-4 semen samples with good quality (forward motility sperm rate > 50%) and semen volume ≥ 4 ml were selected. Each semen sample was divided into 2 equal volumes and processed by density gradient centrifugation and sieve method respectively. We found that the recovery rate of sieve method was significantly lower than that of density gradient centrifugation. From the primary screening area to the secondary screening area to the collection area, the recovery rate gradually decreased and the difference was significant ( Figure 9 A); however, the PR of the primary screening area was close to that of the density gradient centrifugation method, while the PR of the secondary screening area and the collection area was significantly higher than that of the density gradient centrifugation method ( Figure 9 B); Similarly, the NP and DFI of the primary screening area were close to those of the density gradient centrifugation method, while the NP and DFI of the secondary screening area and the collection area were significantly lower than those of the density gradient centrifugation method ( Figure 9 C and D). In summary, although the recovery rate of semen treated with the mesh method was significantly lower than that of conventional density gradient centrifugation, the PR and DFI of the treated sperm were significantly improved. This suggests that the mesh method improves sperm motility and significantly reduces DNA fragmentation, potentially improving oocyte fertilization rate, embryo quality, and pregnancy outcomes.

[0044] In Examples 1 and 2, three heating discs 156 are positioned below the collection tank 162 when the transverse grooves 163 have different lengths. In contrast, three heating discs 156 are positioned below the primary screening area 172, the secondary screening area 173, and the collection area 174, respectively. The heating discs 156 in both configurations are positioned identically within the heating tank 155. To unify the layout of the heating discs 156 and simplify control logic, temperature control can be achieved using the same set of heating components regardless of whether processing board 16 or processing board 2 17 is used, thereby improving the versatility and interchangeability of the device.

[0045] Furthermore, the assisted reproductive semen processing device of the present invention can be configured with multiple processing stations 15 arranged in a row within housing 1, e.g., four to eight, depending on actual usage needs. Each processing station 15 can have its heating temperature independently controlled, facilitating simultaneous large-scale processing operations. Labeling areas 18 are also provided on the edges of processing plate 16 and processing plate 2 17 for attaching labels or identification chips to distinguish sperm from different patients.

[0046] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed. However, as long as such modifications are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. An assisted reproductive semen processing device that matches different insemination methods, characterized by: The invention comprises a box body (1), wherein the front of the box body (1) is provided with an openable box door (2); a processing table (15) is provided in the middle of the bottom of the box body (1), the processing table (15) is provided with a heating component, and a processing board is placed on the processing table (15); a control box (14) is provided at the top of the box body (1), the back of the control box (14) passes through the back of the box body (1) and a heat dissipation plate (11) is provided on the back of the control box (14), and a control circuit board is provided in the control box (14); a display screen (5) is provided on the top of the box body (1) and function buttons (6) and function knobs (7) are provided on both sides; a power supply interface (10) is provided on the back of the box body (1).

2. The assisted reproductive semen processing device according to claim 1, which is compatible with different insemination methods, is characterized in that: The box door (2) is provided with an observation window (3), which is sealed by a sealing plate made of a transparent light-transmitting material; the observation window (3) is provided with a slidable movable baffle (4) made of an opaque material on the outside of the sealing plate; the top of the box body (1) is provided with an observation window (8), which is sealed by a sealing plate made of a transparent light-transmitting material; the observation window (8) is provided with a slidable movable baffle (9) made of an opaque material on the outside of the sealing plate; the inside of the box body (1) is provided with a storage drawer (12) at the bottom, and the storage drawer (12) is used to place a processing board; the processing table (15) is arranged in the middle of the top of the storage drawer (12); and ultraviolet lamps (13) are provided on two opposite sides of the inside of the box body (1).

3. The assisted reproductive semen processing device matching different insemination methods according to claim 1, characterized in that: The processing plate is a processing plate (16), and the processing plate (16) is provided with a lofting groove (161), a collecting groove (162) and a horizontal transverse groove (163); the lofting groove (161) is arranged near one side of the processing plate (16) and is connected to the sampling groove through the transverse groove (163); the processing plate (16) is provided with a mounting column (165) at the bottom near the front and the back, and the processing plate (16) is provided with a handle (164) at the top near the front and the back; the length of the transverse groove (163) is 10mm-15mm, 25mm-35mm or 45mm-55mm.

4. The assisted reproductive semen processing device matching different insemination methods according to claim 3, characterized in that: The length of the transverse groove (163) is 15 mm, 25 mm or 45 mm.

5. The assisted reproductive semen processing device matching different insemination methods according to claim 1, characterized in that: The processing plate is processing plate 2 (17), and processing plate 2 (17) is provided with a processing tank and a screening frame. The processing tank includes a sample setting area (171), a primary screening area (172), a secondary screening area (173) and a collection area (174) arranged in sequence; the sample setting area (171), the primary screening area (172), the secondary screening area (173) and the collection area (174) are symmetrically provided with a limit seat (179) on both sides above the intersection for placing the screening frame; the screening frame includes a circular screening frame (176), a screening net (177) is provided in the middle of the screening frame (176), and a handle (178) is provided on the top of the screening frame (176); the processing plate 2 (17) is provided with a mounting column 2 (175) at the bottom near the front and the back, and the processing plate 2 (17) is provided with a handle 2 (1710) at the top near the front and the back.

6. The assisted reproductive semen processing device matching different insemination methods according to claim 5, characterized in that: The screening mesh (177) is a polycarbonate membrane with different pore sizes and a thickness between 0.2 mm and 0.4 mm; the pore size of the screening mesh (177) of the screening frame between the sample area (171) and the primary screening area (172) is 20 μm; the pore size of the screening mesh (177) of the screening frame between the primary screening area (172) and the secondary screening area (173) is 10 μm; and the pore size of the screening mesh (177) of the screening frame between the secondary screening area (173) and the collection area (174) is 20 μm.

7. The assisted reproductive semen processing device for matching different insemination methods according to any one of claims 3 to 6, characterized in that: The processing table (15) is provided with a placement groove (151) in the middle of the top, and positioning holes (152) are provided on both sides of the placement groove (151) near the edge; the processing plate is positioned and placed on the top of the processing table (15) through the positioning holes (152) and the placement groove (151); a heating groove (155) is provided at the bottom of the placement groove (151) for installing a heating component, a heat-conducting cover plate (153) is provided on the top of the heating groove (155), and a plurality of temperature sensors (154) are provided near the heating groove (155) of the placement groove (151); the heating component includes a heating plate (156), a heating tube (157) and a heat insulation plate (158), and the heat insulation plate (158) is provided at both ends of the heating tube (157).

8. The assisted reproductive semen processing device matching different insemination methods according to claim 7, characterized in that: The number of the heating disks (156) is four; the four heating disks (156) are respectively located below the sample setting area (171), the primary screening area (172), the secondary screening area (173) and the collection area (174); a heating tube (157) is provided between two adjacent heating disks (156).

9. The assisted reproductive semen processing device matching different insemination methods according to claim 7, characterized in that: The number of the heating disks (156) is four; one heating disk (156) is located below the sample slot (161), and the other three heating disks (156) are located below the collecting slot (162) when the transverse slots (163) have different lengths; a heating tube (157) is provided between two adjacent heating disks (156).

10. The assisted reproductive semen processing device matching different insemination methods according to any one of claims 8-9, characterized in that: When the three heating plates (156) are located below the collecting tank (162) in transverse grooves (163) of different lengths, and when the three heating plates (156) are located below the primary screening area (172), the secondary screening area (173) and the collecting area (174), respectively, the heating plates (156) are arranged in the same position in the heating tank (155) in the two arrangement modes.

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