Cosmetic skin conditioner with multiple soothing and repairing functions as well as preparation method and application of cosmetic skin conditioner

Abstract

The invention provides a multi-soothing and repairing cosmetic skin conditioner as well as a preparation method and application thereof. The multi-soothing and repairing cosmetic skin conditioner is prepared from 25 to 45 parts of kava pepper root extract, 10 to 40 parts of radix gentianae extract, 20 to 50 parts of radix stephaniae tetrandrae extract, 10 to 15 parts of hydroxypropyl cyclodextrin and 2 to 5 parts of modified hydroxypropyl cyclodextrin. Wherein the modified hydroxypropyl cyclodextrin is obtained by grafting hydroxypropyl cyclodextrin and glycidyl methacrylate, and then carrying out free radical polymerization on the grafted hydroxypropyl cyclodextrin and glycidyl methacrylate, C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate. The modified hydroxypropyl cyclodextrin is a cross-linked polymer, has a larger molecular structure and a stronger spatial network effect and can form a stable and firm inclusion compound, and meanwhile, a hydrophobic chain segment is introduced, so that the compatibility with a hydrophobic content is effectively improved, phase splitting of the content and release in the storage process can be prevented, and the product stability is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a multiple soothing and repairing cosmetic skin conditioner, a preparation method and application thereof. Background Art

[0002] In today's cosmetics industry, as consumers increasingly demand product efficacy and safety, improving the stability, compatibility, and bioavailability of active ingredients has become a key research and development focus. Plant extracts, as a natural and effective source of active ingredients, show promising application prospects in soothing and repairing applications. However, due to their complex composition and often hydrophobic nature, they are prone to poor stability and inadequate efficacy in formulations. Cyclodextrin, a substance with a unique hollow cyclic structure, is gaining attention in the cosmetics field due to its ability to form inclusion complexes with a variety of active ingredients, offering a new approach to addressing these issues.

[0003] In cosmetic applications, cyclodextrins typically work by forming inclusion complexes with active ingredients. The hydrophobic regions within their ring structures accommodate hydrophobic active ingredients, while the hydrophilic groups on the outside enhance the solubility of the inclusion complex in aqueous systems, thereby improving the dispersibility and stability of the active ingredients. This inclusion complex also reduces direct contact between the active ingredients and the external environment, reducing degradation due to factors such as light and oxidation, and extending the product's shelf life.

[0004] However, the cyclodextrins used in the prior art have certain drawbacks. On the one hand, cyclodextrin itself is a small molecule structure containing a large number of hydroxyl groups and possessing strong polarity, while the active ingredients in plant extracts are mostly hydrophobic substances. The lack of good compatibility between the two makes it easy for phase separation and precipitation to occur in the formulation system, affecting product stability and user experience. On the other hand, because it is a small molecule, its ability to encapsulate the contents is relatively limited, making it difficult to form a stable and strong inclusion complex. This results in the active ingredients being easily released from the inclusion complex during storage, preventing them from fully exerting their intended efficacy. It also has a certain impact on the stability of the contents, which in turn affects the overall performance of the product, limiting its further application in cosmetics.

[0005] In summary, a new technical solution is urgently needed to solve the problems existing in the existing technology. Summary of the Invention

[0006] Based on this, the present invention provides a multi-soothing and repairing cosmetic skin conditioner, its preparation method, and application. By combining plant extracts with cyclodextrin, a skin conditioner with excellent properties is formed. The modified hydroxypropyl cyclodextrin of the present invention is a cross-linked polymer. Its larger molecular structure and stronger spatial network effect enable it to effectively encapsulate active ingredients, forming a stable and robust inclusion complex. Furthermore, the hydrophobic segments introduced into the modified hydroxypropyl cyclodextrin effectively enhance its compatibility with hydrophobic ingredients, effectively preventing phase separation and release during storage, thereby significantly improving product stability.

[0007] One object of the present invention is to provide a multiple soothing and repairing cosmetic skin conditioner, wherein the multiple soothing and repairing cosmetic skin conditioner comprises the following components in parts by weight:

[0008]

[0009] The modified hydroxypropyl cyclodextrin is a polymer obtained by first grafting hydroxypropyl cyclodextrin with glycidyl methacrylate and then free radical polymerizing with C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate.

[0010] Furthermore, the C12-C18 alkyl acrylate is selected from one or more of dodecyl acrylate, tridecyl acrylate, tetradecyl acrylate, pentadecyl acrylate, hexadecyl acrylate, heptadecyl acrylate or octadecyl acrylate.

[0011] Another object of the present invention is to provide a method for preparing the above-mentioned multiple soothing and repairing cosmetic skin conditioner, comprising the following steps:

[0012] S1, mixing hydroxypropyl cyclodextrin and glycidyl methacrylate, heating and reacting to obtain hydroxypropyl cyclodextrin containing double bonds;

[0013] S2, blending the double bond-containing hydroxypropyl cyclodextrin, C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate, adding an initiator, and heating to react to obtain modified hydroxypropyl cyclodextrin;

[0014] S3. Add kava root extract, gentian extract and stephania tetrandra extract to solvent 1 to prepare solution 1; add hydroxypropyl cyclodextrin and modified hydroxypropyl cyclodextrin to solvent 2 to prepare solution 2; add solution 1 to solution 2 under heating and stirring, and continue stirring to react to obtain a multiple soothing and repairing cosmetic skin conditioner.

[0015] Furthermore, the solvent 1 is preferably ethanol; and the solvent 2 is preferably water.

[0016] Furthermore, in step S1, the mass ratio of hydroxypropyl cyclodextrin to glycidyl methacrylate is (5-15):1.

[0017] Furthermore, in step S2, the mass ratio of the double-bond-containing hydroxypropyl cyclodextrin, C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate is 1:(1-4):(2-5).

[0018] Furthermore, in step S1, the heating temperature is 40-60°C.

[0019] Furthermore, in step S2, the heating temperature is 100-120°C.

[0020] Furthermore, in step S3, the heating temperature is 50-70°C.

[0021] Another object of the present invention is to provide a cosmetic composition comprising the above-mentioned multiple soothing and repairing cosmetic skin conditioner.

[0022] The present invention has the following beneficial effects:

[0023] The present invention provides a multiple soothing and repairing cosmetic skin conditioner, and its preparation method and application. The present invention first grafts hydroxypropyl cyclodextrin with glycidyl methacrylate, introduces a double bond into the hydroxypropyl cyclodextrin, and then performs free radical polymerization with C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate to obtain modified hydroxypropyl cyclodextrin. The modified hydroxypropyl cyclodextrin is a cross-linked polymer with a larger molecular structure and a stronger spatial network effect. It has a good coating effect on active ingredients, forming a stable and firm inclusion complex, which can effectively prevent the release of contents during storage and improve the stability of the product. At the same time, the modified hydroxypropyl cyclodextrin also introduces a hydrophobic segment, which effectively improves its compatibility with hydrophobic contents, effectively prevents phase separation, precipitation and other phenomena of the product, and improves the stability and user experience of the product. DETAILED DESCRIPTION

[0024] In order to more clearly illustrate the technical solutions of the present invention, the following examples are given. Unless otherwise stated, the raw materials, reactions and post-processing methods mentioned in the examples are common raw materials on the market and technical methods well known to those skilled in the art.

[0025] The terms "preferred," "preferably," "more preferred," and the like, used herein, refer to embodiments of the invention that may provide certain benefits under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

[0026] It should be understood that, except in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and appended claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.

[0027] The present invention uses the following raw materials:

[0028] Kava root extract, gentian extract, and tetrandragone extract were purchased from Shaanxi Changxiang Pharmaceutical Co., Ltd.

[0029] Hydroxypropyl cyclodextrin: purchased from Shaanxi Changxiang Pharmaceutical Co., Ltd.

[0030] The water in the present invention is all deionized water.

[0031] The "parts" in the present invention refer to parts by mass.

[0032] Example 1

[0033] A multiple soothing and repairing cosmetic skin conditioner, comprising the following components in parts by weight:

[0034]

[0035] The modified hydroxypropyl cyclodextrin is a polymer obtained by first grafting hydroxypropyl cyclodextrin with glycidyl methacrylate and then free radical polymerizing with lauryl acrylate and methoxy polyethylene glycol methacrylate.

[0036] The preparation method of the above-mentioned multiple soothing and repairing cosmetic skin conditioner comprises the following steps:

[0037] S1. Using a sodium hydroxide aqueous solution (20 wt%) as a solvent, hydroxypropyl cyclodextrin and glycidyl methacrylate (the mass ratio of hydroxypropyl cyclodextrin to glycidyl methacrylate is 6:1) are blended and reacted at 60° C. for 4 h. After the reaction, a hydrochloric acid solution (10 wt%) is added to adjust the pH to 6-7. The reaction product is then precipitated with petroleum ether, filtered, and dried to obtain hydroxypropyl cyclodextrin containing a double bond;

[0038] S2. Using propylene glycol methyl ether as a solvent, blending hydroxypropyl cyclodextrin containing a double bond, lauryl acrylate, and methoxy polyethylene glycol methacrylate (the mass ratio of hydroxypropyl cyclodextrin containing a double bond, lauryl acrylate, and methoxy polyethylene glycol methacrylate is 1:3:2), adding dibenzoyl peroxide (1 wt % of the reactant), heating and stirring at 120° C. for 7 h, removing the solvent by distillation under reduced pressure, washing with water, and drying to obtain modified hydroxypropyl cyclodextrin;

[0039] S3. Add kava root extract, gentian extract and stephania tetrandra extract to ethanol according to the above-mentioned mass fractions to prepare solution 1 (solute mass concentration of 50 wt%); add hydroxypropyl cyclodextrin and modified hydroxypropyl cyclodextrin to water, stir and dissolve at 60°C to prepare solution 2 (solute mass concentration of 5 wt%); while maintaining the heating conditions and stirring, add solution 1 to solution 2, continue stirring and reacting for 4 hours, filter, wash and dry to obtain a multiple soothing and repairing cosmetic skin conditioner.

[0040] Example 2

[0041] A multiple soothing and repairing cosmetic skin conditioner, comprising the following components in parts by weight:

[0042]

[0043] The modified hydroxypropyl cyclodextrin is a polymer obtained by first grafting hydroxypropyl cyclodextrin with glycidyl methacrylate and then free radical polymerizing with pentadecyl acrylate and methoxy polyethylene glycol methacrylate.

[0044] The preparation method of the above-mentioned multiple soothing and repairing cosmetic skin conditioner comprises the following steps:

[0045] S1. Using a sodium hydroxide aqueous solution (20 wt%) as a solvent, hydroxypropyl cyclodextrin and glycidyl methacrylate (the mass ratio of hydroxypropyl cyclodextrin to glycidyl methacrylate is 8:1) are blended and reacted at 50°C for 5 h. After the reaction, a hydrochloric acid solution (10 wt%) is added to adjust the pH to 6-7. The reaction product is then precipitated with petroleum ether, filtered, and dried to obtain hydroxypropyl cyclodextrin containing a double bond;

[0046] S2. Using propylene glycol methyl ether as a solvent, blending hydroxypropyl cyclodextrin containing a double bond, pentadecyl acrylate, and methoxy polyethylene glycol methacrylate (the mass ratio of hydroxypropyl cyclodextrin containing a double bond, pentadecyl acrylate, and methoxy polyethylene glycol methacrylate is 1:2:2), adding dibenzoyl peroxide (1 wt % of the reactant), heating and stirring at 110° C. for 8 h, and removing the solvent by distillation under reduced pressure, washing with water, and drying to obtain modified hydroxypropyl cyclodextrin;

[0047] S3. Add kava root extract, gentian extract and stephania tetrandra extract to ethanol according to the above-mentioned mass fractions to prepare solution 1 (solute mass concentration of 50 wt%); add hydroxypropyl cyclodextrin and modified hydroxypropyl cyclodextrin to water, stir and dissolve at 55°C to prepare solution 2 (solute mass concentration of 5 wt%); while maintaining the heating conditions and stirring, add solution 1 to solution 2, continue stirring and reacting for 4 hours, filter, wash, and dry to obtain a multiple soothing and repairing cosmetic skin conditioner.

[0048] Example 3

[0049] A multiple soothing and repairing cosmetic skin conditioner, comprising the following components in parts by weight:

[0050]

[0051] The modified hydroxypropyl cyclodextrin is a polymer obtained by first grafting hydroxypropyl cyclodextrin with glycidyl methacrylate and then free radical polymerizing octadecyl acrylate and methoxy polyethylene glycol methacrylate.

[0052] The preparation method of the above-mentioned multiple soothing and repairing cosmetic skin conditioner comprises the following steps:

[0053] S1. Using a sodium hydroxide aqueous solution (20 wt%) as a solvent, hydroxypropyl cyclodextrin and glycidyl methacrylate (the mass ratio of hydroxypropyl cyclodextrin to glycidyl methacrylate is 10:1) are blended, and the mixture is reacted at 60° C. for 5 h. After the reaction, a hydrochloric acid solution (10 wt%) is added to adjust the pH to 6-7. The reaction product is then precipitated with petroleum ether, filtered, and dried to obtain hydroxypropyl cyclodextrin containing a double bond;

[0054] S2. Using propylene glycol methyl ether as a solvent, blending hydroxypropyl cyclodextrin containing a double bond, octadecyl acrylate, and methoxy polyethylene glycol methacrylate (the mass ratio of hydroxypropyl cyclodextrin containing a double bond, octadecyl acrylate, and methoxy polyethylene glycol methacrylate is 1:2:4), adding dibenzoyl peroxide (1 wt% of the reactant), heating and stirring at 110° C. for 7 h, and removing the solvent by distillation under reduced pressure. The mixture was washed with water and dried to obtain modified hydroxypropyl cyclodextrin;

[0055] S3. Add kava root extract, gentian extract and stephania tetrandra extract to ethanol according to the above-mentioned mass fractions to prepare solution 1 (solute mass concentration of 50 wt%); add hydroxypropyl cyclodextrin and modified hydroxypropyl cyclodextrin to water, stir and dissolve at 60°C to prepare solution 2 (solute mass concentration of 5 wt%); while maintaining the heating conditions and stirring, add solution 1 to solution 2, continue stirring and reacting for 4 hours, filter, wash and dry to obtain a multiple soothing and repairing cosmetic skin conditioner.

[0056] Comparative Example 1

[0057] A multiple soothing and repairing cosmetic skin conditioner. The difference between this comparative example and Example 1 is that steps S1-S2 are omitted, and the modified hydroxypropyl cyclodextrin is replaced with unmodified hydroxypropyl cyclodextrin. The other steps and amounts are the same as those in Example 1.

[0058] Comparative Example 2

[0059] A multiple soothing and repairing cosmetic skin conditioner. The difference between this comparative example and Example 1 is that in step S2, lauryl acrylate and methoxy polyethylene glycol methacrylate are not added, and the other steps and amounts are the same as those in Example 1.

[0060] Test Case

[0061] The performance of the multiple soothing and repairing cosmetic skin conditioners of Examples 1-3 and Comparative Examples 1-2 was tested.

[0062] Test method:

[0063] (1) A multi-soothing and repairing cosmetic skin conditioner was placed in a sealed container at room temperature and humidity for 6 months, and its appearance was observed.

[0064] (2) Use a colorimeter to test the color difference of cosmetic skin conditioners at 0 month and after 6 months under normal temperature and humidity conditions.

[0065] The test results are shown in Table 1.

[0066] Table 1 Performance test results of multiple soothing and repairing cosmetic skin conditioners

[0067]

[0068] As can be seen from the above test results, the modified hydroxypropyl cyclodextrin of the present invention, after polymerization and the introduction of hydrophobic groups, has good compatibility with hydrophobic contents. The multiple soothing and repairing cosmetic skin conditioner prepared using the modified hydroxypropyl cyclodextrin has uniform color and small color difference after 6 months of placement, indicating that the components of the present invention have good compatibility, cyclodextrin coating is good, and the components are not easy to phase separate. Comparative Example 1 uses unmodified hydroxypropyl cyclodextrin, which is a small molecule structure, contains a large number of hydroxyl groups, has strong polarity, and has poor compatibility with hydrophobic contents; and because it is a small molecule itself, the coating effect on the contents is limited, and after being placed for a long time, phase separation occurs, and the color difference is more obvious. Although the hydroxypropyl cyclodextrin of Comparative Example 2 is polymerized, no hydrophobic groups are introduced, and the component compatibility is poor, so phase separation also occurs, and there is also a large color difference.

[0069] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations that come within the meaning and range of equivalents of the claims be embraced therein.

[0070] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A multi-soothing and repairing cosmetic skin conditioner, characterized in that: The multi-soothing and repairing cosmetic skin conditioner comprises the following ingredients in parts by weight: The modified hydroxypropyl cyclodextrin is a polymer obtained by first grafting hydroxypropyl cyclodextrin with glycidyl methacrylate and then free radical polymerizing with C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate.

2. The multi-soothing and repairing cosmetic skin conditioner according to claim 1, characterized in that: The C12-C18 alkyl acrylate is selected from one or more of lauryl acrylate, tridecyl acrylate, tetradecyl acrylate, pentadecyl acrylate, hexadecyl acrylate, heptadecyl acrylate or octadecyl acrylate.

3. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to any one of claims 1 to 2, characterized in that: The steps include: S1, mixing hydroxypropyl cyclodextrin and glycidyl methacrylate, heating and reacting to obtain hydroxypropyl cyclodextrin containing double bonds; S2, blending the double bond-containing hydroxypropyl cyclodextrin, C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate, adding an initiator, and heating to react to obtain modified hydroxypropyl cyclodextrin; S3. Add kava root extract, gentian extract and stephania tetrandra extract to solvent 1 to prepare solution 1; add hydroxypropyl cyclodextrin and modified hydroxypropyl cyclodextrin to solvent 2 to prepare solution 2; add solution 1 to solution 2 under heating and stirring, and continue stirring to react to obtain a multiple soothing and repairing cosmetic skin conditioner.

4. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to claim 3, characterized in that: In step S1, the mass ratio of hydroxypropyl cyclodextrin to glycidyl methacrylate is (5-15):

1.

5. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to claim 3, characterized in that: In step S2, the mass ratio of the double-bond-containing hydroxypropyl cyclodextrin, C12-C18 alkyl acrylate and methoxy polyethylene glycol methacrylate is 1:(1-4):(2-5).

6. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to claim 3, characterized in that: In step S1, the heating temperature is 40-60°C.

7. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to claim 3, characterized in that: In step S2, the heating temperature is 100-120°C.

8. The method for preparing the multi-soothing and repairing cosmetic skin conditioner according to claim 3, characterized in that: In step S3, the heating temperature is 50-70°C.

9. A cosmetic composition, characterized in that A cosmetic skin conditioner comprising the multiple soothing and repairing agent according to any one of claims 1 to 2.

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