Rapid liquid cover film independent temperature control method for treating pathological specimen and treatment device

Abstract

The invention discloses a rapid liquid cover film independent temperature control method for treating a pathological specimen and a treatment device, and the method comprises the steps: 1, covering a cover plate with a slide, and enabling a reagent to flow into a capillary cavity through a liquid inlet so as to form a liquid cover film; step 2, heating the liquid in the incubator by a heater; step 31, obtaining a voltage value; step 32, obtaining a first temperature value according to the voltage value, and obtaining a real-time resistance value according to the first temperature value; step 33, judging whether the real-time resistance value is an end point of the interval of the resistance-temperature comparison table, if so, determining that an end point temperature value corresponding to the end point is a real-time temperature value, and executing step 35, otherwise, executing step 34; 34, end point temperature values corresponding to the two end points of the interval are obtained and subjected to linear fitting, the fitting temperature value of the real-time resistance value is obtained, the fitting temperature value is the real-time temperature value, and then the step 35 is executed; step 35, outputting a real-time temperature value; and step 4, realizing temperature control according to the real-time temperature value. The incubator has the advantage that the incubation temperature is accurately controlled.

Description

Technical Field

[0001] The present invention relates to the technical field of pathological specimen processing, in particular to a rapid liquid-covered membrane independent temperature control method and a processing device for processing pathological specimens. Background Art

[0002] Pathology specimen processing requires inserting a slide into a slot in a specimen holder. The specimen holder is then placed in an incubator. A heater heats the liquid within the incubator, which in turn heats (boils) the slide. A temperature sensor in the incubator detects the real-time temperature of the liquid, and the heater is controlled accordingly to achieve temperature control. Existing temperature sensors, such as platinum resistance temperature measurement devices, lack accurate real-time temperature readings due to the lack of calibration. This results in poor temperature control accuracy, leading to a need for further improvement. Summary of the Invention

[0003] The present invention provides a rapid liquid-covered membrane independent temperature control method and a processing device for processing pathological specimens, which overcome the shortcomings of the background technology.

[0004] One of the technical solutions adopted by the present invention to solve the technical problem is: a rapid liquid-covered membrane independent temperature control method for processing pathological specimens, comprising:

[0005] Step 1: The slide unit includes a cover plate and a slide. The slide is connected to the cover plate to form a liquid inlet and a capillary cavity connected to the liquid inlet. The reagent flows from top to bottom into the capillary cavity through the liquid inlet to form a liquid cover film. The slide unit is inserted into the slot of the specimen holder, and the specimen holder is placed in the incubator of the incubation unit.

[0006] Step 2: The heater of the incubation component heats the liquid in the incubation box;

[0007] Step 3: The temperature detection device of the incubation component detects the temperature of the liquid in the incubator in real time and outputs the real-time temperature value, which includes:

[0008] Step 31: The platinum resistor of the dual-bridge temperature measurement circuit senses the temperature of the liquid in the incubator, and an analog-to-digital converter is connected to the output terminal of the operational amplifier of the dual-bridge temperature measurement circuit to obtain a voltage value;

[0009] Step 32, calculating a first temperature value of the liquid based on the voltage value, and calculating a real-time resistance value of the temperature measuring platinum resistor based on the first temperature value;

[0010] Step 33, based on the real-time resistance value, retrieve the interval in which the real-time resistance value is located in the resistance-temperature comparison table of the dual-bridge temperature measurement circuit, and determine whether the real-time resistance value is an endpoint of the interval. If so, obtain the endpoint temperature value corresponding to the endpoint from the resistance-temperature comparison table. The endpoint temperature value is the real-time temperature value, and then execute step 35; otherwise, execute step 34;

[0011] Step 34, obtaining the endpoint temperature values ​​corresponding to the two endpoints of the interval from the resistance-temperature comparison table, linearly fitting the endpoint temperature values ​​of the two endpoints, and calculating to obtain a fitting temperature value where the real-time resistance value is located on the fitting line, the fitting temperature value is the real-time temperature value, and then executing step 35; and

[0012] Step 35, outputting the real-time temperature value; and

[0013] Step 4: Control the heater according to the real-time temperature value to achieve temperature control.

[0014] In one embodiment: in step 31, the reference voltage of the dual-bridge temperature measurement circuit is 4.096V;

[0015] In step 32, the first temperature value is T, the voltage value is U0, and the real-time resistance value is R. The first temperature value and the real-time resistance value are calculated using the following formula:

[0016] R=1000+3.85T.

[0017] In one embodiment: In step 31, the dual-bridge temperature measurement circuit includes a dual-bridge circuit consisting of a temperature measuring platinum resistor and three resistors R1, R2, and R3. The dual-bridge circuit has two first input terminals and two first output terminals. The two first input terminals are respectively connected to a reference voltage and ground. The two first output terminals are respectively connected to two second input terminals of the operational amplifier circuit through resistors R4 and R5. The grounded first input terminal of the dual-bridge circuit is also connected to a second input terminal of the operational amplifier circuit through resistor R6. The other second input terminal of the operational amplifier circuit is connected to the second output terminal through resistor R7.

[0018] The second technical solution adopted by the present invention to solve its technical problem is: a rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens, including a frame, an incubation device, a sample loading mechanism and a driving mechanism; the incubation device includes multiple incubation components, each of which is independently provided with an incubation box that is pulled out and connected to the frame, a specimen holder placed in the incubation box, a heater that is installed in the incubation box and heats the liquid in the incubation box, a temperature detection device and a controller for real-time detection of the temperature of the liquid in the incubation box; the specimen holder is provided with multiple slots, into which glass slide units can be inserted, and the glass slide unit includes a cover plate and a glass slide, and the glass slide is covered with the cover plate to form The invention relates to a liquid inlet and a capillary cavity connected to the liquid inlet. When the reagent flows into the capillary cavity from top to bottom through the liquid inlet, a liquid cover film can be formed, and the glass slide unit is heated by the liquid in the incubator. The temperature detection device includes a temperature sensor, an analog-to-digital converter and a correction module. The temperature sensor is a double-bridge temperature measurement circuit using a temperature-measuring platinum resistor. The analog-to-digital converter is connected to the double-bridge temperature measurement circuit. The correction module is connected to the analog-to-digital converter. The controller is connected to the correction module and the heater. The incubation component realizes temperature control according to the rapid liquid cover film independent temperature control method for processing pathological specimens. The driving mechanism drives the sample loading mechanism to move above the glass slide unit to load the sample to the glass slide unit.

[0019] In one embodiment: the incubator includes an insulation box and a pot body located inside the insulation box; the specimen holder has a main body, the main body is provided with the above-mentioned slot, one end of the main body is provided with a handle, the handle and the other end of the main body are mounted on the upper edge of the pot body, and the main body is located in the pot body; the heater is installed on the back end surface of the bottom of the pot body.

[0020] In one embodiment: the heater is divided into multiple heating modules, and the multiple heating modules are flatly installed on the back end surface of the pot bottom; the pot body includes a pot bottom and a pot wall extending upward from the periphery of the pot bottom, the pot bottom is arranged tilted up and down, and the pot body is provided with a mounting hole passing through the inside and outside, the position of the mounting hole corresponds to the inclined lower end of the pot bottom and the lowest point of the mounting hole is flush with or slightly higher than the inclined lower end, and the temperature sensor is installed in the mounting hole.

[0021] In one embodiment: the cover plate has a base plate and two side flanges fixed on both sides of the base plate. The base plate includes an inclined plate and a capillary plate fixed together above and below. The inclined plate is arranged obliquely relative to the capillary plate. A lug is protruded from the middle of the lower side of the capillary plate, and a support hook is fixed to the lug. The glass slide is supported on the support hook and overlapped on the two side flanges to cover the base plate.

[0022] In one embodiment, the incubation boxes of the multiple incubation components are arranged side by side.

[0023] Compared with the background technology, this technical solution has the following advantages:

[0024] Determine whether the real-time resistance value is the endpoint of the interval. If so, obtain the endpoint temperature value corresponding to the endpoint from the resistance-temperature comparison table. The endpoint temperature value is directly constructed as the real-time temperature value, and the real-time temperature value is accurate. Otherwise, obtain the endpoint temperature values ​​corresponding to the two endpoints of the interval from the resistance-temperature comparison table, linearly fit the endpoint temperature values ​​of the two endpoints and the endpoint temperature values ​​of the two endpoints, and calculate to obtain the fitting temperature value where the real-time resistance value is located on the fitting line. The fitting temperature value is the real-time temperature value, and the fitting temperature is very close to the real-time temperature value. The real-time temperature value is accurate. The heater is controlled to heat according to the real-time temperature value to achieve temperature control, which can achieve precise control of the incubation temperature of different repair conditions. The entire process is controlled within ±0.5°C to ensure the consistency of the repair temperature of the glass slide unit in each incubator (±0.5°C).

[0025] The reference voltage of the dual-bridge temperature measurement circuit is 4.096V. The first temperature value and the real-time resistance value are calculated by the formula R=1000+3.85T is calculated, and the control is precise. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0027] Figure 1 It is a three-dimensional schematic diagram of an incubation component for placing a specimen holder according to a specific embodiment.

[0028] Figure 2 It is a three-dimensional schematic diagram of a specimen holder with a slide unit inserted therein according to a specific embodiment.

[0029] Figure 3 It is a three-dimensional schematic diagram of the incubation component of a specific embodiment.

[0030] Figure 4 It is a side view schematic diagram of an incubation component for placing a specimen holder according to a specific embodiment.

[0031] Figure 5 It is a cross-sectional schematic diagram of an incubation component for placing a specimen holder according to a specific embodiment.

[0032] Figure 6 4 is a flow chart of real-time temperature correction according to a specific embodiment.

[0033] Figure 7 is a linear fitting coordinate graph of real-time temperature correction according to a specific embodiment.

[0034] Figure 8 2 is a schematic diagram of a double-bridge temperature measurement circuit according to a specific embodiment.

[0035] Figure 9 It is a schematic diagram of the three-dimensional structure of a processing device according to a specific embodiment.

[0036] Description of labels:

[0037] Frame A, incubation device B, sample loading mechanism C, drive mechanism D, reagent component E, support surface A1, X-axis guide rail A2, X-axis sliding seat A3;

[0038] Cover plate 21, specimen holder 22, glass slide 23, slot 24;

[0039] Incubation box 3, heater 31, temperature sensor 32, double-bridge temperature measurement circuit 33, insulation box 34, pot body 35, pot bottom 351, liquid inlet connector 36, liquid discharge connector 37. DETAILED DESCRIPTION

[0040] A rapid liquid-covered membrane temperature control method for processing pathological specimens, including:

[0041] Step 1, please refer to Figure 1-Figure 5 The slide unit includes a cover plate 21 and a glass slide 23. The glass slide 23 covers the cover plate 21 to form a liquid inlet and a capillary cavity connected to the liquid inlet. When a reagent flows into the capillary cavity from top to bottom through the liquid inlet, a liquid cover film covering the pathological specimen can be formed. The slide unit is inserted into the slot 24 of the specimen holder 22, and the specimen holder 22 is placed in the incubator 3 of the incubation component;

[0042] Step 2: The heater 31 of the incubation component heats the liquid in the incubation box 3;

[0043] Step 3: The temperature detection device of the incubation component detects the temperature of the liquid in the incubator 3 in real time and outputs the real-time temperature value. Figure 6-Figure 8 , which includes:

[0044] In step 31, the platinum resistor of the dual-bridge temperature measurement circuit 33 senses the temperature of the liquid in the incubator 3, and the analog-to-digital converter is connected to the operational amplifier output terminal (second output terminal) of the dual-bridge temperature measurement circuit 33 to obtain a voltage value; wherein: the dual-bridge temperature measurement circuit 33 includes a dual-bridge circuit composed of a platinum resistor and three resistors R1, R2, and R3, the dual-bridge circuit has two first input terminals and two first output terminals, the two first input terminals are respectively connected to the reference voltage and the ground GND, the two first output terminals are respectively connected to the two second input terminals of the operational amplifier circuit through resistors R4 and R5, the grounded first input terminal of the dual-bridge circuit is also connected to a second input terminal of the operational amplifier circuit through resistor R6, and the other second input terminal of the operational amplifier circuit is also connected to the second output terminal through resistor R7.

[0045] The reference voltage of this dual-bridge temperature measurement circuit is 4.096V. If a PT1000 platinum resistor is used for temperature measurement, its nominal resistance is 1kΩ. The resistance values ​​of R1 and R2 are both 20kΩ, the resistance value of R3 is 1kΩ, the resistance values ​​of R4 and R5 are both 10kΩ, and the resistance values ​​of R6 and R7 are both 500kΩ. The op amp circuit uses an OPA227 with a 50x amplification factor. This circuit can achieve precise control of the incubation temperature under different repair conditions. With the help of calibration, the entire process is controlled within ±0.5°C.

[0046] Step 32, calculating a first temperature value of the liquid based on the voltage value, and calculating a real-time resistance value of the temperature-measuring platinum resistor based on the first temperature value; wherein: the first temperature value is T, the voltage value is U0, and the real-time resistance value is R, and the first temperature value and the real-time resistance value are calculated using the following formula;

[0047] R=1000+3.85T.

[0048] Step 33, based on the real-time resistance value, retrieve the interval where the real-time resistance value is located in the resistance-temperature comparison table (storage table), and determine whether the real-time resistance value is an endpoint of the interval. If so, obtain the endpoint temperature value corresponding to the endpoint from the resistance-temperature comparison table of the dual-bridge temperature measurement circuit. The endpoint temperature value is the real-time temperature value, and then execute step 35; otherwise, execute step 34;

[0049] Step 34, obtain the endpoint temperature values ​​corresponding to the two endpoints of the interval from the resistance-temperature comparison table of the dual-bridge temperature measurement circuit, and perform linear fitting of the two endpoints and the two endpoint temperature values ​​to obtain a linear fitting equation. For example, if the two endpoints are X1 and X2, and the two endpoint temperature values ​​are Y1 and Y2, then the linear fitting equation Y=kx+d is obtained by (X1, Y1) and (X2, Y2). The fitting temperature value of the real-time resistance value located on the fitting line is calculated according to the linear fitting equation. The fitting temperature value is the real-time temperature value, and then step 35 is executed; and

[0050] Step 35, outputting the real-time temperature value; and

[0051] Step 4: Control the heater according to the real-time temperature value to achieve temperature control. If the real-time temperature value is lower than a first predetermined value, the heater starts heating; if the real-time temperature value is higher than a second predetermined value, the heater is turned off.

[0052] The above resistance-temperature comparison table is provided by the manufacturer, and the comparison table records the resistance ranges and the temperature values ​​corresponding to the endpoints of each range.

[0053] For rapid liquid-covered membrane temperature-controlled processing devices for pathological specimens, please refer to Figure 1-5 、 Figure 8-9It includes a frame A, an incubation device B, a sample loading mechanism C, a driving mechanism D and a reagent component E. The incubation device B includes a plurality of incubation components, each of which is independently provided with an incubation box 3 that is pulled out and connected to a support surface A1, a specimen holder 22 placed in the incubation box 3, a heater 31 that is attached to the incubation box 3 and heats the liquid in the incubation box 3, a temperature detection device and a controller that detects the temperature of the liquid in the incubation box 3 in real time. The temperature of the liquid in each incubation box can be independently controlled by the separately provided controller, temperature detection device and heater to achieve independent temperature control; the specimen holder 2 is provided with a plurality of slots 24, into which a glass slide unit can be inserted, and the glass slide unit includes a cover plate 21 and a glass slide 23, and the glass slide 23 covers the cover plate 21 to form a liquid inlet and a cap connected to the liquid inlet. A fine cavity, the reagent flows into the capillary cavity from top to bottom through the liquid inlet to form a liquid cover film covering the pathological specimen. If the reagent can enter the capillary cavity through eddy current to mix and cover the pathological specimen to achieve eddy current mixing, the glass slide unit is heated by the liquid in the incubator 3; the temperature detection device includes a temperature sensor 32, an analog-to-digital converter and a correction module. The temperature sensor 32 is a double-bridge temperature measurement circuit 33 using a temperature measuring platinum resistor. The analog-to-digital converter is connected to the operational amplifier circuit of the double-bridge temperature measurement circuit 33, the correction module is connected to the analog-to-digital converter, and the controller is connected to the correction module and the heater 31. The incubation component adopts the above-mentioned rapid liquid cover film separate temperature control method for processing pathological specimens to achieve temperature control.

[0054] The incubator 3 includes an insulation box 34 and a pot body 35 located within the insulation box 34. The pot body 35 includes a pot bottom 351 and a pot wall extending upward from the periphery of the pot bottom. The pot bottom 351 is arranged at an angle. The pot body 35 is provided with a mounting hole extending inside and outside. The mounting hole is located at the lower end of the pot bottom 351 and is slightly higher than the lower end. The temperature sensor 32 is installed in the mounting hole. The temperature sensor 32 can detect the real-time temperature of the liquid at the lowest point in the pot body 35 in real time and accurately detect the liquid temperature. The slight height difference is 1-5 mm. A liquid inlet joint 36 and a liquid discharge joint 37 are also provided, extending through the interior and exterior of the incubator 3, to allow for liquid injection or drainage.

[0055] The specimen holder 22 has a main body, which is provided with the above-mentioned slot 24. A handle is provided at one end of the main body. The handle and the other end of the main body are mounted on the upper edge of the pot wall of the pot body 35, and the main body is located inside the pot body 35; the heater 31 is installed on the back end surface of the pot bottom 351. In order to improve the uniformity of heating, the heater 31 is divided into multiple heating modules, and the multiple heating modules are flatly installed on the back end surface of the pot bottom 351.

[0056] The cover plate 21 comprises a bottom plate and two side flanges fixedly mounted on both sides of the bottom plate. The bottom plate comprises an inclined plate and a capillary plate fixedly mounted together at the top and bottom. The inclined plate is arranged obliquely relative to the capillary plate. A lug is protruding from the middle portion of the lower side of the capillary plate, and a support hook is fixed to the lug. The glass slide is supported on the support hook and overlapped on the flanges on both sides to cover the bottom plate. The glass slide and the inclined plate cooperate to form a liquid inlet that is larger at the top and smaller at the bottom. The glass slide and the capillary plate cooperate to form a capillary cavity.

[0057] The frame A includes a support surface A1, on which a first area and a second area are arranged on the left and right sides. Multiple incubation boxes 3 of incubation components are arranged side by side in the first area, and the reagent component E is provided in the second area. The reagent component E has multiple reagent bottles, and the reagent bottles are filled with reagents.

[0058] The driving mechanism D drives the sample loading mechanism C to move onto the reagent component to extract the reagent, and to move onto the glass slide unit to load the sample reagent into the glass slide unit. The support surface A1 is fixedly provided with a support frame, and the top of the support frame is fixedly provided with an X-axis guide rail A2. The X-axis guide rail A2 is provided with an X-axis sliding seat A3 that can slide along the X-axis. The X-axis sliding seat A3 is provided with a Y-axis guide rail. The Y-axis guide rail is provided with a Y-axis sliding seat that can slide along the Y-axis. The Y-axis sliding seat is provided with a Z-axis movable seat that can move along the Z-axis. The sample loading mechanism C is mounted on the Z-axis movable seat.

[0059] The above description is merely a preferred embodiment of the present invention and therefore cannot be used to limit the scope of the present invention. In other words, equivalent changes and modifications made according to the scope of the present invention and the contents of the specification should still fall within the scope of the present invention.

Claims

1. A rapid liquid-covered membrane temperature control method for processing pathological specimens, characterized by: include: Step 1: The slide unit includes a cover plate and a slide. The slide is connected to the cover plate to form a liquid inlet and a capillary cavity connected to the liquid inlet. The reagent flows from top to bottom into the capillary cavity through the liquid inlet to form a liquid cover film. The slide unit is inserted into the slot of the specimen holder, and the specimen holder is placed in the incubator of the incubation unit. Step 2: The heater of the incubation component heats the liquid in the incubation box; Step 3: The temperature detection device of the incubation component detects the temperature of the liquid in the incubator in real time and outputs the real-time temperature value, which includes: Step 31: The platinum resistor of the dual-bridge temperature measurement circuit senses the temperature of the liquid in the incubator, and an analog-to-digital converter is connected to the output terminal of the operational amplifier of the dual-bridge temperature measurement circuit to obtain a voltage value; Step 32, calculating a first temperature value of the liquid based on the voltage value, and calculating a real-time resistance value of the temperature measuring platinum resistor based on the first temperature value; Step 33, based on the real-time resistance value, retrieve the interval in which the real-time resistance value is located in the resistance-temperature comparison table of the dual-bridge temperature measurement circuit, and determine whether the real-time resistance value is an endpoint of the interval. If so, obtain the endpoint temperature value corresponding to the endpoint from the resistance-temperature comparison table. The endpoint temperature value is the real-time temperature value, and then execute step 35; otherwise, execute step 34; Step 34, obtaining the endpoint temperature values ​​corresponding to the two endpoints of the interval from the resistance-temperature comparison table, linearly fitting the endpoint temperature values ​​of the two endpoints, and calculating to obtain a fitting temperature value where the real-time resistance value is located on the fitting line, the fitting temperature value is the real-time temperature value, and then executing step 35; and Step 35, outputting the real-time temperature value; and Step 4: Control the heater according to the real-time temperature value to achieve temperature control.

2. The method for rapid liquid-covered membrane temperature control for processing pathological specimens according to claim 1, characterized in that: In step 31, the reference voltage of the dual-bridge temperature measurement circuit is 4.096V; In step 32, the first temperature value is T, the voltage value is U0, and the real-time resistance value is R. The first temperature value and the real-time resistance value are calculated using the following formula: R=1000+3.85T。 3. The rapid liquid-covered membrane independent temperature control method for processing pathological specimens according to claim 1, characterized in that: In step 31, the dual-bridge temperature measurement circuit includes a dual-bridge circuit consisting of a temperature measuring platinum resistor and three resistors R1, R2, and R3. The dual-bridge circuit has two first input terminals and two first output terminals. The two first input terminals are respectively connected to a reference voltage and ground. The two first output terminals are respectively connected to two second input terminals of the operational amplifier circuit through resistors R4 and R5. The grounded first input terminal of the dual-bridge circuit is also connected to a second input terminal of the operational amplifier circuit through resistor R6. The other second input terminal of the operational amplifier circuit is connected to the second output terminal through resistor R7.

4. A rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens, characterized by: The incubator comprises a frame, an incubation device, a sample loading mechanism and a driving mechanism; the incubation device comprises a plurality of incubation components, each of which is independently provided with an incubation box that is pulled out and connected to the frame, a specimen holder placed in the incubation box, a heater that is installed in the incubation box and heats the liquid in the incubation box, a temperature detection device and a controller that detects the temperature of the liquid in the incubation box in real time; the specimen holder is provided with a plurality of slots, into which glass slide units can be inserted, the glass slide unit comprises a cover plate and a glass slide, the glass slide is covered with the cover plate to form a liquid inlet and a capillary cavity connected to the liquid inlet, and the reagent flows from top to bottom through the liquid inlet A liquid cover film can be formed in the capillary cavity, and the glass slide unit is heated by the liquid in the incubator; the temperature detection device includes a temperature sensor, an analog-to-digital converter and a correction module, the temperature sensor is a double-bridge temperature measurement circuit using a temperature-measuring platinum resistor, the analog-to-digital converter is connected to the double-bridge temperature measurement circuit, the correction module is connected to the analog-to-digital converter, the controller is connected to the correction module and the heater, the incubation component realizes temperature control according to the rapid liquid cover film independent temperature control method for processing pathological specimens according to claim 1, 2 or 3; the driving mechanism drives the sample loading mechanism to move above the glass slide unit to load the sample to the glass slide unit.

5. The rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens according to claim 4, characterized in that: The incubator comprises an insulation box and a pot body located inside the insulation box; the specimen holder comprises a main body, the main body is provided with the above-mentioned slot, one end of the main body is provided with a handle, the handle and the other end of the main body are mounted on the upper edge of the pot body, and the main body is located inside the pot body; the heater is installed on the back end surface of the bottom of the pot body.

6. The rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens according to claim 5, characterized in that: The heater is divided into multiple heating modules, which are installed flat on the back end surface of the pot bottom; the pot body includes a pot bottom and a pot wall extending upward from the periphery of the pot bottom, the pot bottom is arranged tilted up and down, and the pot body is provided with a mounting hole passing through the inside and outside, the position of the mounting hole corresponds to the inclined lower end of the pot bottom and the lowest point of the mounting hole is flush with or slightly higher than the inclined lower end, and the temperature sensor is installed in the mounting hole.

7. The rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens according to claim 4, characterized in that: The cover plate comprises a base plate and two side flanges fixed on both sides of the base plate. The base plate comprises an inclined plate and a capillary plate fixed together upper and lower. The inclined plate is arranged obliquely relative to the capillary plate. A lug is protruding from the middle of the lower side of the capillary plate, and a support hook is fixed on the lug. The glass slide is supported on the support hook and overlapped on the flanges on both sides to cover the base plate.

8. The rapid liquid-covered membrane independent temperature control processing device for processing pathological specimens according to claim 4, characterized in that: The incubation boxes of the plurality of incubation parts are arranged side by side.

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