Large-view-field high-resolution fundus imaging system and method

Abstract

The invention discloses a large-field-of-view high-resolution fundus imaging system and method, and belongs to the field of adaptive optical imagines.The large-field-of-view high-resolution fundus imaging system is characterized in that light of a light source is divided into multiple beams by a beam splitter, and the multiple beams of light enter human eyes through a first spectroscope and an aberration correction module to be reflected by fundus; the multiple beams of reflected light carry respective small-view-field human eye aberrations, pass through the aberration correction module and are reflected by the first spectroscope to reach the confocal detection module; the confocal detection module collects small-view-field human eye aberration of the multiple beams of reflected light to generate multiple image signals and evaluates the aberration according to the quality of the multiple image signals so as to generate feedback signals to drive the aberration correction module to carry out aberration correction on the multiple beams of reflected light at the same time until the system reaches the diffraction limit. The large-view-field high-resolution fundus imaging system can synchronously correct aberration of different view fields, the aberration correction time is shortened, and the overall imaging speed is increased.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of adaptive optics imaging, in particular to a large field of view high resolution fundus imaging system and method. BACKGROUND

[0002] Adaptive optics fundus imaging technology is a new optical technology realized in 1997 abroad. This technology measures the aberration of human eye by using wavefront sensor, and then uses wavefront corrector to correct the aberration of human eye to within the diffraction limit, so as to realize high resolution imaging of human eye retina. However, the traditional adaptive optics fundus imaging technology only performs average aberration correction on the whole imaging field of view according to the aberration reference points in the imaging field of view. Due to the non-isoplanatism of human eye aberration, the high resolution imaging area is limited to the vicinity of the fovea of human eye, and the high resolution imaging field of view is small, typically 1°-2°.

[0003] Patent US8201943B2 discloses an adaptive optics line scanning ophthalmoscope system, which proposes a method for expanding the high resolution field of view. In this method, the aberration of specific positions in the whole imaging field of view is corrected respectively, and the isoplanatic regions of different positions are connected together to achieve the purpose of expanding the high resolution imaging field of view. Although this method expands the high resolution imaging field of view, with the further expansion of the high resolution imaging field of view, the number of sub-fields of view that need to be corrected also increases, and the overall aberration correction time also increases, thereby slowing down the system imaging speed. Therefore, under the condition of ensuring the system imaging speed, the ability of this method to expand the high resolution imaging field of view is limited. SUMMARY

[0004] In order to overcome the shortcomings of the prior art, one of the purposes of the present application is to provide a large field of view high resolution fundus imaging system capable of synchronously correcting the aberration of different fields of view, shortening the aberration correction time and improving the overall imaging speed.

[0005] In order to overcome the shortcomings of the prior art, the second purpose of the present application is to provide a large field of view high resolution fundus imaging method capable of synchronously correcting the aberration of different fields of view, shortening the aberration correction time and improving the overall imaging speed.

[0006] One of the purposes of the present application is achieved by adopting the following technical solutions:

[0007] A large field of view high resolution fundus imaging system, comprising a light source module, a first beam splitter, an aberration correction module and a confocal detection module, the light source module comprising a light source and a beam splitter, the beam splitter being located between the light source and the first beam splitter, the beam splitter dividing the light from the light source into multiple beams, the multiple beams passing through the first beam splitter and the aberration correction module to enter the human eye and be reflected by the fundus, the aberration correction module comprising a curved liquid crystal lens array, the curved liquid crystal lens array being located near the pupil conjugate plane and applying a large defocus amount to each of the multiple beams, the defocus amount applied to the middle beam being small, and the defocus amount applied to the edge beam gradually increasing radially outward, so that the ideal imaging plane of the system is transformed from a plane to a curved surface with the same curvature as the fundus by the curved liquid crystal lens array, and the light reflected by the fundus curved surface can also be transformed into a plane at the confocal detection module by the curved liquid crystal lens array, the multiple reflected beams carrying the respective small field of view human eye aberration pass through the aberration correction module and are reflected by the first beam splitter to the confocal detection module, the confocal detection module collects the small field of view human eye aberration of the multiple reflected beams to generate multiple image signals and evaluates the size of the aberration according to the quality of the multiple image signals to generate a feedback signal to drive the aberration correction module to simultaneously correct the aberration of the multiple reflected beams until the system reaches the diffraction limit.

[0008] Further, the curved liquid crystal lens array comprises a plurality of liquid crystal microlenses, the number of the liquid crystal microlenses being equal to the number of the beams split by the beam splitter, and the plurality of liquid crystal microlenses synchronously apply different defocus amounts to different beams.

[0009] Further, the aberration correction module comprises a transmissive liquid crystal spatial light modulator, the working area of the transmissive liquid crystal spatial light modulator being divided into a plurality of areas, the number of the working areas being equal to the number of the beams split by the beam splitter, and the transmissive liquid crystal spatial light modulator synchronously applies different aberration corrections to different beams.

[0010] Further, the aberration correction module further comprises a first beam folding prism and a second beam folding prism, the curved liquid crystal lens array and / or the transmissive liquid crystal spatial light modulator being located between the first beam folding prism and the second beam folding prism, the first beam folding prism applying different folding angles to each of the beams so that the pupils of the beams can be separated at the curved liquid crystal lens array or the transmissive liquid crystal spatial light modulator, and the second beam folding prism applying folding angles opposite to those of the first beam folding prism to each of the beams so that the pupils of the beams can be combined together again.

[0011] Further, the aberration correction module further comprises a first positive lens, a second positive lens, a third positive lens and a fourth positive lens, the first light beam deflection prism is located between the first positive lens and the second positive lens, the second light beam deflection prism is located between the third positive lens and the fourth positive lens, the first positive lens, the second positive lens, the third positive lens and the fourth positive lens have the same parameters and jointly form a 4f system, and the beam splitter is located at a focal point of the first positive lens.

[0012] Further, the confocal detection module comprises an imaging lens, a confocal pinhole array and a multi-point detector arranged in sequence, the imaging lens images the fundus to the multi-point detector, and the confocal pinhole array is used for isolating out-of-focus reflected light and improving the contrast and imaging quality of an image.

[0013] Further, the large-field high-resolution fundus imaging system further comprises a scanning module, the scanning module is located between the aberration correction module and the human eye, and the scanning module comprises a vertical scanning galvanometer, a fifth positive lens, a sixth positive lens, a horizontal scanning galvanometer and an aberration balancing lens arranged in sequence along an optical path, the vertical scanning galvanometer is optically conjugated with the horizontal scanning galvanometer, the fifth positive lens and the sixth positive lens form a 4f system, and the aberration balancing lens balances the residual aberration of the light source module, the aberration correction module and the scanning module.

[0014] Further, the large-field high-resolution fundus imaging system further comprises an ocular module, the ocular module comprises a first doublet lens and a second doublet lens, the first doublet lens and the second doublet lens form a 4f system together with the aberration balancing lens to determine the size of the fundus imaging field of view.

[0015] Further, the large-field high-resolution fundus imaging system further comprises a target module and a second light splitter, the target module comprises a target and a collimating lens, the second light splitter is located between the ocular module and the human eye, the target module is located on one side of the second light splitter, the collimating lens images the target to infinity, and the target reflected by the second light splitter enters the human eye, so that the human eye remains focused at infinity.

[0016] The second purpose of the application is achieved by the following technical scheme:

[0017] A large-field high-resolution fundus imaging method is implemented by using any one of the large-field high-resolution fundus imaging systems, and comprises the following steps:

[0018] Beam splitting: the light in the light source module is collimated and polarized, and then split into N*M beams, N and M are integers, so that the large field of view of the fundus is divided into N*M small fields of view, and the light beams correspond to the small fields of view one by one.

[0019] Reflection: N*M beams of light enter the human eye and are reflected by the fundus;

[0020] Image acquisition and judgment: N*M beams of transmitted light carrying their own small field of view of the human eye aberration reach the confocal detection module to generate image signals, and then the quality of the image is evaluated to determine the size of the aberration;

[0021] Correction: When the image quality does not meet the requirements, a feedback signal is generated, which drives the aberration correction module located between the light source module and the human eye. The transmissive liquid crystal spatial light modulator applies different correction signals to each region, thereby correcting the human eye aberration of each small field of view of the fundus. The curved liquid crystal lens array synchronously applies different defocusing amounts to different light beams. The corrected light is re-acquired and judged until the image quality meets the requirements, and the image signal is a high-resolution image of the retina.

[0022] Compared with the prior art, the beam splitter of the large field of view high resolution fundus imaging system divides the light source into multiple beams. The multiple beams of light pass through the first beam splitter and the aberration correction module, enter the human eye and are reflected by the fundus. The multiple beams of reflected light carrying their own small field of view of the human eye aberration pass through the aberration correction module and are reflected by the first beam splitter to reach the confocal detection module. The confocal detection module acquires the small field of view of the human eye aberration of the multiple beams of reflected light to generate multiple image signals and evaluate the size of the aberration according to the quality of the multiple image signals, thereby generating a feedback signal to drive the aberration correction module to correct the aberration of the multiple beams of reflected light simultaneously until the system reaches the diffraction limit. Through the above design, the large field of view high resolution fundus imaging system can correct the aberration of different fields of view synchronously, shorten the time of aberration correction, and improve the overall imaging speed. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 The optical path diagram of the large field of view high resolution fundus imaging system of the present application;

[0024] Figure 2 The flowchart of the large field of view high resolution fundus imaging method of the present application.

[0025] In the figure: 1, light source module; 101, light source; 102, confocal pinhole; 103, collimating mirror; 104, polarizer; 105, beam splitter; 201, first beam splitter; 3, aberration correction module; 301, first positive lens; 302, first beam deflection prism; 303, second positive lens; 304, curved liquid crystal lens array; 305, transmissive liquid crystal spatial light modulator; 306, third positive lens; 307, second beam deflection prism; 308, fourth positive lens; 4, scanning module; 401, vertical scanning galvanometer; 402, fifth positive lens; 403, sixth positive lens; 404, horizontal scanning galvanometer; 405, aberration balancing lens; 5, eyepiece module; 501, first doublet; 502, second doublet; 202, second beam splitter; 6, human eye; 7, confocal detection module; 701, imaging lens; 702, confocal pinhole array; 703, multi-point detector; 8, target module; 801, target; 802, collimating lens. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0027] It should be noted that when a component is referred to as being "fixed" to another component, it can be directly on the other component or can be fixed thereto via an intermediate component. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or can be connected thereto via an intermediate component. When a component is referred to as being "disposed" on another component, it can be directly on the other component or can be disposed thereon via an intermediate component. The terms "vertical", "horizontal", "left", "right", and similar terms as used herein are for illustrative purposes only.

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0029] Figure 1 The present application discloses a large field of view and high resolution fundus imaging system, and the large field of view and high resolution fundus imaging system is used for high resolution imaging of a retina of a human eye 6.

[0030] The large field of view high resolution fundus imaging system comprises a light source module 1, a first beam splitter 201, a second beam splitter 202, an aberration correction module 3, a scanning module 4, an eyepiece module 5, a confocal detection module 7 and a target module 8. The light source module 1, the first beam splitter 201 and the aberration correction module 3 are located on the same straight line, and the first beam splitter 201 is located between the light source module 1 and the aberration correction module 3. The confocal detection module 7 is located on one side of the first beam splitter 201. The scanning module 4 is located between the aberration correction module 3 and the eyepiece module 5. The second beam splitter 202 is located between the eyepiece module 5 and the human eye 6, and the target module 8 is located on one side of the second beam splitter 202.

[0031] The light source module 1 is used for generating a plurality of beams of linearly polarized light for fundus scanning imaging, and comprises, in sequence along the optical axis, a light source 101, a confocal pinhole 102, a collimating mirror 103, a polarizer 104 and a beam splitting device 105. The light emitted by the light source 101 is collimated by the collimating mirror 103, then becomes linearly polarized light by the polarizer 104, and is then split into a plurality of beams of light with uniform energy distribution by the beam splitting device 105.

[0032] The light source 101 used in the light source module 1 is an 820 nm superluminescent diode, and the beam splitting device 105 is a diffractive optical element (DOE). The light beam is split into N*M beams, where N and M are integers. The confocal pinhole 102 and the confocal pinhole array 702 in the confocal detection module 7 form a confocal relationship with the fundus, and the polarization direction of the polarizer 104 is parallel to the liquid crystal e-axis of the curved liquid crystal lens array 304 and the transmission type liquid crystal spatial light modulator 305 in the aberration correction module 3.

[0033] The first beam splitter 201 is used for reflecting the reflected light of the fundus to the confocal detection module 7, so that the confocal detection module 7 collects the aberration of the small field of view human eye 6 of the plurality of beams of reflected light.

[0034] The aberration correction module 3 is used for synchronously correcting the N*M beams of light reflected by the fundus, and comprises, in sequence along the optical axis, a first positive lens 301, a first beam folding prism 302, a second positive lens 303, a curved liquid crystal lens array 304, a transmission type liquid crystal spatial light modulator 305, a third positive lens 306, a second beam folding prism 307 and a fourth positive lens 308. The four positive lenses have consistent parameters and together form a 4f system. The beam splitting device 105 in the light source module 1 is located at the focal point of the first positive lens 301, the first beam folding prism 302 and the second beam folding prism 307 are optically conjugated, and the transmission type liquid crystal spatial light modulator 305 is in Fourier transform relationship with the first beam folding prism 302 and the second beam folding prism 307.

[0035] The functions of the first beam folding prism 302 and the second beam folding prism 307 in the present example are the shift property and the frequency domain property of Fourier transform. The first beam folding prism 302 is used to apply different folding angles to each light beam so that the pupils of the light beams can be separated at the transmissive liquid crystal spatial light modulator 305, and thus the transmissive liquid crystal spatial light modulator 305 can apply different aberration corrections to different light beams synchronously. The second beam folding prism 307 is used to apply folding angles opposite to those of the first beam folding prism 302 to each light beam so that the pupils of the light beams can be combined together again.

[0036] The N*M light beams divide a large field of view of the fundus into a plurality of small fields of view. Similarly, the working area of the transmissive liquid crystal spatial light modulator 305 is also divided into N*M areas, and the curved liquid crystal lens array 304 also has N*M liquid crystal microlenses. The small fields of view of the fundus, the working areas of the transmissive liquid crystal spatial light modulator 305, and the single liquid crystal microlenses of the curved liquid crystal lens array 304 correspond to each other one by one. The first beam folding prism 302 makes the pupils of the N*M light beams spatially separated and fall on the corresponding areas of the transmissive liquid crystal spatial light modulator 305. The transmissive liquid crystal spatial light modulator 305 applies different correction signals to each area, thereby correcting the eye aberration of each small field of view of the fundus. In the present example, the main function of the transmissive liquid crystal spatial light modulator 305 is to correct the high-order aberration of the human eye, and the main function of the curved liquid crystal lens array 304 is to correct the defocus amount caused by the refractive error of the human eye.

[0037] The function of the scanning module 4 is to realize two-dimensional scanning of the fundus. The scanning module 4 along the optical axis comprises a vertical scanning galvanometer 401, a fifth positive lens 402, a sixth positive lens 403, a horizontal scanning galvanometer 404, and an aberration balancing lens 405 in sequence. The fifth positive lens 402 and the sixth positive lens 403 form a 4f system, and the aberration balancing lens 405 and the objective lens module 5 form a 4f system. The vertical scanning galvanometer 401 and the horizontal scanning galvanometer 404 are optically conjugated. The function of the aberration balancing lens 405 is to balance the residual aberration of the light source module 1, the aberration correction module 3, and the scanning module 4. Since the N*M light beams share the scanning module 4, the large field of view of the fundus is divided into N*M small fields of view which are uniformly and equally divided. The N*M light beams complete the scanning of the respective small fields of view through the scanning module 4 at the same time. All the small fields of view satisfy the principle of aberration equalization. The field of view in the X and Y scanning directions does not exceed 2° of the intraocular angle. The N*M small fields of view overlap with each other at the imaging edges. This is to eliminate the joint artifact. After image stitching algorithm processing, a large field of view fundus image without joint artifact can be generated.

[0038] The eyepiece module 5 determines the size of the field of view of the fundus that can be imaged, and is well balanced in internal aberration, and is a replaceable component. In the embodiment, the eyepiece module 5 includes a first doublet lens 501 and a second doublet lens 502, which are symmetrically distributed and constitute a symmetric eyepiece.

[0039] The confocal detection module 7 receives the imaging light reflected from the fundus, and sequentially includes an imaging lens 701, a confocal pinhole array 702, and a multi-point detector 703 along the optical axis. The imaging lens 701 images the fundus to the multi-point detector 703, and the confocal pinhole array 702 is used to isolate the out-of-focus reflected light, thereby improving the contrast and imaging quality of the image. In the embodiment, the multi-point detector used is a multi-anode photomultiplier tube, and the number of collection channels is N*M, which corresponds to the light beams generated in the light source module 1.

[0040] The target module 8 is used to keep the human eye focused at infinity, and sequentially includes a target 801 and a collimating lens 802 along the optical axis. The collimating lens 802 images the target 801 to infinity, and the image is reflected by the second beam splitter 202 into the human eye, so that the human eye is kept focused at infinity.

[0041] When the large-field high-resolution fundus imaging system is used, the light emitted by the target 801 is reflected by the second beam splitter 202 into the human eye after collimation, so that the human eye is focused at infinity. The light in the light source module 1 is collimated and polarized, and then split into N*M beams, so that the large field of view of the fundus is divided into N*M small fields of view, and the light beams correspond to the small fields of view one by one. The first beam deflection prism 302 in the aberration correction module 3 applies a different deflection angle to each light beam, so that the pupils of different light beams can be separated in space, thereby synchronously correcting the aberration of the fundus at different positions at the pupil. After the multi-beam is corrected in refraction and aberration, it is combined again by the second beam deflection prism 307, so that the pupils separated in space are combined again, and it is ensured that the light beams can enter the human eye from the pupil. After the corrected light beams pass through the scanning module 4, they enter the human eye, are reflected by the fundus, and then return to the first beam splitter 201, and the imaging light signal reflected is collected and finally converted into image information output.

[0042] The large field of view high resolution fundus imaging system used in the embodiment is a wavefront detection free adaptive optical method, and the specific process is that N*M beams of light are emitted into the human eye and reflected by the fundus, N*M beams of emitted light carrying respective small field of view human eye aberrations reach the confocal detection module to generate image signals, and then the size of the aberration is judged according to the quality of the image, so as to generate a feedback signal to drive the aberration correction module 3 to implement aberration correction. The aberration correction module 3 in the embodiment has a bidirectional effect, one is to make the light transmitted to the human eye better focused on the fundus of the human eye, and the other is to make the light reflected by the fundus better focused on the detector. The large field of view high resolution fundus imaging system of the application is a wavefront detection free adaptive optical system, and the control algorithm used in the system is typically a stochastic parallel gradient descent (SPGD) algorithm. The voltage signal of the wavefront corrector (liquid crystal spatial light modulator 305 and curved liquid crystal lens array 304) is controlled by the algorithm, and the evaluation index of the quality of the image is generally the Strehl ratio (SR). When SR>0.8, it is considered that the system reaches the diffraction limit, and the aberration correction is completed.

[0043] Please continue to refer to Figure 2 The application also discloses a large field of view high resolution fundus imaging method, which is implemented by using the large field of view high resolution fundus imaging system and comprises the following steps.

[0044] Beam splitting: the light in the light source module 1 is collimated and polarized, and then is split into N*M beams, N and M are integers, so that the large field of view of the fundus is divided into N*M small fields of view, and the light beams correspond to the small fields of view one by one;

[0045] Reflection: N*M beams of light are emitted into the human eye 6 and reflected by the fundus;

[0046] Image acquisition and judgment: N*M beams of emitted light carrying respective small field of view human eye aberrations reach the confocal detection module 7 to generate image signals, and then the size of the aberration is judged according to the quality of the image;

[0047] Correction: when the image quality does not meet the requirements, a feedback signal is generated, the feedback signal drives the aberration correction module 3 located between the light source 101 module 1 and the human eye 6, the transmission type liquid crystal spatial light modulator 305 applies different correction signals to each region, thereby correcting the human eye 6 aberration of each small field of view of the fundus, and the curved liquid crystal lens array 304 synchronously applies different defocusing amounts to different light beams. The light after correction is re-acquired and judged in the image acquisition and judgment step until the image quality meets the requirements, and the image signal is a high resolution retinal image.

[0048] Compared with the prior art, the beam splitter 105 of the large-field high-resolution fundus imaging system divides the light of the light source 101 into multiple beams, the multiple beams of light pass through the first beam splitter 201 and the aberration correction module 3, are reflected by the fundus, carry the respective small-field eye 6 aberration, pass through the aberration correction module 3, are reflected by the first beam splitter 201 to the confocal detection module 7, the confocal detection module 7 collects the small-field eye 6 aberration of the multiple beams of reflected light to generate multiple image signals, evaluates the size of the aberration according to the quality of the multiple image signals, and thus generates a feedback signal to drive the aberration correction module 3 to simultaneously correct the multiple beams of reflected light until the system reaches the diffraction limit, the image quality meets the requirements, through the above design, the large-field high-resolution fundus imaging system can correct the aberration of different fields synchronously, shorten the aberration correction time, and improve the overall imaging speed. The system adopts the method of wavefront detection-free adaptive optics, saves the wavefront sensor, simplifies the optical path, and reduces the cost; the curved liquid crystal lens array 304 is adopted to correct the eye refraction, and the pressure of the wavefront corrector is reduced; the objective lens used in the system can be replaced, and different imaging requirements can be adapted. The system can increase the high-resolution imaging field of view of the fundus by scanning the number of imaging beams. Through the above improvements, the system can effectively shorten the aberration correction time, further expand the high-resolution imaging field of view of the fundus, realize large-field high-resolution fundus imaging for different conditions of the eye, and provide more effective information for ophthalmic clinical examination.

[0049] The above embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it cannot be understood as limiting the scope of the patent. It should be noted that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are equivalent modifications and evolutions of the above embodiments according to the essential technology of the present application, and these all belong to the protection scope of the present application.

Claims

1. A large-field-of-view, high-resolution fundus imaging system, comprising a light source module, a first beam splitter, an aberration correction module, and a confocal detection module, characterized in that: The light source module includes a light source and a beam splitter, the beam splitter is located between the light source and the first beam splitter, the beam splitter divides the light of the light source into multiple beams, the multiple beams pass through the first beam splitter and the aberration correction module and enter the human eye and are reflected by the fundus, the aberration correction module includes a curved liquid crystal lens array, the curved liquid crystal lens array is located near the pupil conjugate plane and applies a large defocus amount to the multiple beams, the defocus amount applied to the middle beam is small, and the defocus amount applied to the edge beam gradually increases radially outward, so that the ideal imaging surface of the system is formed by a plane passing through the curved liquid crystal lens. The array is transformed into a curved surface with the same curvature as the fundus, and the light reflected from the curved surface of the fundus can also be transformed into a plane at the confocal detection module through the curved liquid crystal lens array. Multiple beams of reflected light carrying their respective small-field human eye aberrations pass through the aberration correction module and are reflected by the first beam splitter to reach the confocal detection module. The confocal detection module collects the small-field human eye aberrations of the multiple beams of reflected light to generate multiple image signals and evaluates the size of the aberrations based on the quality of the multiple image signals, thereby generating a feedback signal to drive the aberration correction module to simultaneously perform aberration correction on the multiple beams of reflected light until the system reaches the diffraction limit.

2. The large-field-of-view, high-resolution fundus imaging system according to claim 1, characterized in that: The curved liquid crystal lens array includes a plurality of liquid crystal micro lenses, the number of which is equal to the number of light splittings by the beam splitter, and the plurality of liquid crystal micro lenses synchronously apply different defocus amounts to different light beams.

3. The large-field-of-view, high-resolution fundus imaging system according to claim 1, characterized in that: The aberration correction module includes a transmissive liquid crystal spatial light modulator, wherein the working area of ​​the transmissive liquid crystal spatial light modulator is divided into multiple areas, the number of which is equal to the number of light splittings by the beam splitter, and the transmissive liquid crystal spatial light modulator synchronously applies different aberration corrections to different light beams.

4. The large-field-of-view, high-resolution fundus imaging system according to claim 2 or 3, characterized in that: The aberration correction module also includes a first beam deflecting prism and a second beam deflecting prism. The curved liquid crystal lens array and / or the transmissive liquid crystal spatial light modulator are located between the first beam deflecting prism and the second beam deflecting prism. The first beam deflecting prism applies a different deflection angle to each light beam so that the pupil of each light beam can be separated at the curved liquid crystal lens array or the transmissive liquid crystal spatial light modulator. The second beam deflecting prism applies a deflection angle opposite to that of the first beam deflecting prism to each light beam so that the pupil of each light beam can be reunited.

5. The large-field-of-view, high-resolution fundus imaging system according to claim 4, characterized in that: The aberration correction module also includes a first positive lens, a second positive lens, a third positive lens and a fourth positive lens. The first beam deflecting prism is located between the first positive lens and the second positive lens, and the second beam deflecting prism is located between the third positive lens and the fourth positive lens. The parameters of the first positive lens, the second positive lens, the third positive lens and the fourth positive lens are the same and together constitute a 4f system. The beam splitter is located at the focus of the first positive lens.

6. The large-field-of-view, high-resolution fundus imaging system according to claim 1, characterized in that: The confocal detection module includes an imaging lens, a confocal pinhole array and a multi-point detector arranged in sequence. The imaging lens images the fundus onto the multi-point detector, and the confocal pinhole array is used to isolate out-of-focus reflected light to improve image contrast and imaging quality.

7. The large-field-of-view, high-resolution fundus imaging system according to claim 1, characterized in that: The large-field-of-view, high-resolution fundus imaging system also includes a scanning module, which is located between the aberration correction module and the human eye. The scanning module includes a vertical scanning galvanometer, a fifth positive lens, a sixth positive lens, a horizontal scanning galvanometer, and an aberration balancing lens arranged in the order of the optical path. The vertical scanning galvanometer is optically conjugate with the horizontal scanning galvanometer, the fifth positive lens and the sixth positive lens form a 4f system, and the aberration balancing lens balances the residual aberrations of the light source module, the aberration correction module, and the scanning module.

8. The large-field-of-view, high-resolution fundus imaging system according to claim 7, characterized in that: The large-field-of-view, high-resolution fundus imaging system also includes an eyepiece module, which includes a first doublet lens and a second doublet lens. The first doublet lens, the second doublet lens and the aberration-balancing lens form a 4f system that determines the size of the field of view in which the fundus can be imaged.

9. The large-field-of-view, high-resolution fundus imaging system according to claim 8, characterized in that: The large-field-of-view, high-resolution fundus imaging system also includes a sight mark module and a second beam splitter. The sight mark module includes a sight mark and a collimating lens. The second beam splitter is located between the eyepiece module and the human eye. The sight mark module is located on one side of the second beam splitter. The collimating lens images the sight mark to infinity, which is reflected by the second beam splitter into the human eye, so that the human eye remains focused on infinity.

10. A method for large-field-of-view high-resolution fundus imaging, implemented using the large-field-of-view high-resolution fundus imaging system according to any one of claims 1 to 9, characterized in that: The following steps are involved: Beam splitting: After the light in the light source module is collimated and polarized, it is split into N*M beams, where N and M are both integers, so that the large field of view of the fundus is divided into N*M small fields of view, and the beams correspond to the small fields of view one by one; Reflection: N*M beams of light enter the human eye and are reflected by the fundus; Image acquisition and judgment: N*M beams of emitted light carrying the human eye aberration of each small field of view arrive at the confocal detection module and are collected to generate image signals, and then the size of the aberration is judged according to the quality of the image; Correction: When the image quality does not meet the requirements, a feedback signal is generated. The feedback signal drives the aberration correction module located between the light source module and the human eye. The transmissive liquid crystal spatial light modulator applies different correction signals to each area, thereby correcting the human eye aberration of each small field of view of the fundus. The curved liquid crystal lens array synchronously applies different defocus amounts to different light beams. The corrected light re-captures the image and performs the judgment steps until the image quality meets the requirements. The image signal is a high-resolution retinal image.

Images