Medicine for dispelling effects of alcohol and protecting liver and preparation method thereof

Abstract

The invention discloses a medicine for dispelling effects of alcohol and protecting liver and a preparation method thereof. The medicine is prepared from kudzuvine root, hovenia dulcis thunb, orange peel, fructus alpiniae oxyphyllae, raw malt and rosa roxburghii tratt. The traditional Chinese medicine has the effects of eliminating alcohol toxicity, tonifying spleen and removing food retention, protecting liver and kidney, relieving restlessness and arresting vomiting, and inducing astringency and stopping diarrhea; the wine accumulation syndrome is mainly treated. The wine is suitable for the symptoms such as excessive drinking, drunkenness, vomiting and acid regurgitation, chest and diaphragm distension and stuffiness, dizziness and headache, polydipsia, disadvantageous urination and defecation and the like, and can also be used for preventing drunkenness.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of medicine for dispelling alcohol and protecting liver and preparation method thereof, belong to the technical field of pharmaceuticals. BACKGROUND

[0002] Alcoholism is commonly known as drunk, it is the abnormal state of body function that patients drink a large amount of alcohol (ethanol) at a time, and the damage to nervous system and liver is the most serious. It is divided into acute poisoning and chronic poisoning in medicine, the former can bring great harm to patients in a short time, and even can directly or indirectly lead to death. The latter brings cumulative damage to patients, such as alcohol dependence, mental disorder, alcoholic cirrhosis and induction of some cancers (oral cancer, tongue cancer, esophageal cancer, liver cancer) and so on.

[0003] At present, the treatment of alcohol poisoning patients generally adopts repeated emesis or gastric lavage, but if drinking more than 1 hour, the effect of gastric lavage will be greatly reduced, because most of the alcohol drunk is absorbed within 1 hour. There is no particularly effective drug for alcohol poisoning.

[0004] The present application is aimed at drunk crowd or preventing drunk, and has the effects of dispelling alcohol, invigorating the spleen, eliminating accumulation, protecting liver and kidney, relieving restlessness and vomiting, and has the effect of treating alcohol accumulation. It is suitable for excessive drinking, drunk, vomiting and acid regurgitation, chest and diaphragm oppression, dizziness and headache, thirst, and difficulty in urination and defecation. SUMMARY

[0005] The technical problem to be solved by the present application is to provide a kind of medicine for dispelling alcohol and protecting liver and preparation method thereof. The present application has the effects of dispelling alcohol, invigorating the spleen, eliminating accumulation, protecting liver and kidney, relieving restlessness and vomiting, and has the effect of treating alcohol accumulation. It is suitable for excessive drinking, drunk, vomiting and acid regurgitation, chest and diaphragm oppression, dizziness and headache, thirst, and difficulty in urination and defecation. It can also be used to prevent drunk.

[0006] To solve the above technical problems, the present application adopts the following technical scheme: A kind of medicine for dispelling alcohol and protecting liver and preparation method thereof, the medicinal effective component is calculated according to weight component: 50-500 parts of radix puerariae, 50-500 parts of hovenia dulcis thunb, 30-300 parts of citrus peel, 30-300 parts of fructus alpiniae oxyphyllae, 50-500 parts of raw malt and 50-500 parts of roxburgh rose are used to make.

[0007] The aforementioned medicine for dispelling alcohol and protecting liver and preparation method thereof, the medicinal effective component is calculated according to weight component: 100-200 parts of radix puerariae, 100-200 parts of hovenia dulcis thunb, 50-150 parts of citrus peel, 50-150 parts of fructus alpiniae oxyphyllae, 100-200 parts of raw malt and 100-200 parts of roxburgh rose are used to make.

[0008] Specifically, the aforementioned alcohol-protecting liver medicine and its preparation method, the medicinal effective components are calculated according to the weight components: 150 parts of Pueraria, 150 parts of Hovenia dulcis Thunb, 100 parts of orange peel, 100 parts of Chinese yam, 150 parts of raw malt, and 150 parts of Rosa roxburghii Tratt.

[0009] The preparation method of the aforementioned alcohol-protecting liver medicine is to combine the medicinal materials in the prescription with the pharmaceutically acceptable excipients, and process them according to the conventional method to form the corresponding medicinal preparation.

[0010] The aforementioned medicinal preparation is decoction, oral liquid, hard capsule, tablet, or granule.

[0011] The aforementioned decoction is prepared as follows: the medicinal materials are weighed according to the prescription ratio, crushed into coarse powder, soaked in 8 times the amount of water for 0.5 h, and decocted for 3 times, 1 h each time. The three decoctions are combined and mixed, and when the concentration reaches 70% of the original medicinal liquid, it is filtered while hot. The filtrate is concentrated to 70℃, and the relative density of the extract is 1.10-1.20. Then, 45% of the weight of the aforementioned extract is added to the extract, stirred evenly, and heated on a low fire to collect the extract. When a small amount of the extract can be pulled into a silk or dropped on paper without water marks, it is sealed in a sterile bottle to obtain the decoction.

[0012] The aforementioned oral liquid is prepared as follows: the medicinal materials are weighed according to the prescription ratio, soaked in 6 times the amount of water for 0.5 h, and decocted for 3 times, 1.5 h each time. The three decoctions are combined and mixed, and when the concentration reaches 70% of the original medicinal liquid, it is filtered while hot. The filtrate is concentrated to 60℃, and the relative density of the extract is 1.10-1.20. Then, 10% of granulated sugar is added, stirred evenly, and left for 24 hours. After centrifugation and filtration, the filtrate is diluted with 1000 ml of distilled water, and then packaged to obtain the oral liquid.

[0013] The aforementioned hard capsule is prepared as follows: the medicinal materials are weighed according to the prescription ratio, soaked in 10 times the amount of water for 0.5 h, and decocted for 2 times, 1.5 h each time. The three decoctions are combined and mixed, and when the concentration reaches 70% of the original medicinal liquid, it is filtered while hot. The filtrate is concentrated to 70℃, and the relative density of the extract is 1.10-1.20. Then, the extract is dried at 70℃ to obtain dry extract, which is crushed into fine powder. Then, 10% of starch is added to the powder, stirred evenly, granulated with 75% ethanol, dried, and filled into capsules to obtain the hard capsule.

[0014] The aforementioned tablet is prepared as follows: the medicinal materials are weighed according to the prescription ratio, soaked in 12 times the amount of water for 0.5 h, and decocted for 2 times, 2 h each time. The three decoctions are combined and mixed, and when the concentration reaches 70% of the original medicinal liquid, it is filtered while hot. The filtrate is concentrated to 70℃, and the relative density of the extract is 1.10-1.20. Then, the extract is dried at 70℃ and crushed into fine powder to obtain dry extract. The dry extract is sieved through a 16-mesh sieve, mixed with 0.5% of micronized silica gel and 1% of talc powder, and then compressed into tablets and coated with a film to obtain the tablet.

[0015] The granules are prepared as follows: weigh each medicinal material according to the prescribed ratio, soak it in 8 times the amount of water for 0.5 h, and then decoct it three times, each time for 0.5 h. The three decoctions are combined and mixed, and concentrated to 70% of the original medicinal solution. The mixture is filtered while hot, and the filtrate is concentrated to an extract with a relative density of 1.10-1.20 at 70°C. The extract is dried at 70°C and pulverized into a fine powder to obtain a dry extract. The dry extract is mixed with 20% sucrose and 5% dextrin to form a soft material, which is passed through a 16-mesh sieve to form granules. The granules are dried to obtain the granules.

[0016] Compared with the prior art, the present invention has the following beneficial effects: The alcohol-detoxifying and liver-protecting drug and its preparation method are prepared from kudzu root, Hovenia dulcis fruit, tangerine peel, Alpinia oxyphylla seed, raw malt, and Rosa roxburghii. The properties and efficacy of each ingredient are as follows: Kudzu root is the dried root of Pueraria lobata (Willd.) Ohwi, a plant of the Leguminosae family. It has a sweet and pungent flavor and a cooling nature. It enters the spleen, stomach, and lung meridians. It has the effects of relieving muscle tension and reducing fever, promoting fluid production and quenching thirst, clearing rashes, promoting yang and relieving diarrhea, promoting blood circulation and activating collaterals, and detoxifying alcohol. It is used to treat exogenous fever, headache, stiff neck and back pain, thirst, polydipsia, measles that has not fully cleared, dysentery, diarrhea, dizziness and headache, hemiplegia caused by stroke, chest pain and heartache, and alcohol toxicity. Hovenia dulcis fruit is the seed of Hovenia dulcis Thunb., a plant of the Rhamnaceae family. It has a sweet flavor and a neutral nature. It primarily clears heat and promotes urination, relieves cough and restlessness, and detoxifies alcohol. It is used to treat fever, thirst, hiccups, vomiting, dysuria, and alcohol poisoning. Tangerine peel, also known as dried tangerine peel, is the dried mature peel of the citrus (Citrus reticulata Blanco) plant and its cultivated varieties in the Rutaceae family. It has a bitter and pungent taste and warm nature. It enters the lung and spleen meridians and has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is used to treat abdominal distension, loss of appetite, vomiting and diarrhea, and cough with excessive sputum. Alpinia oxyphylla Miq. is the dried mature fruit of the ginger family plant. The fruit is harvested in summer and autumn when it turns red from green and then sun-dried or low-temperature dried. It has a pungent taste and warm nature and enters the spleen and kidney meridians. It has the effects of warming the spleen, stopping diarrhea, regulating salivation, warming the kidneys, reducing urination, and consolidating semen. It is commonly used to treat spleen and stomach deficiency-cold, vomiting, diarrhea, cold abdominal pain, excessive salivation, kidney deficiency-induced enuresis, frequent urination, nocturnal emission, and leukorrhea. Barley malt is a processed product derived from the germinated, dried, and mature fruit of the grass plant Hordeum vulgare L. It has a sweet taste and a neutral nature. It enters the spleen and stomach meridians and promotes qi and digestion, invigorates the spleen and stimulates appetite, and relieves bloating and distension. It is used to treat indigestion, abdominal distension and pain, spleen deficiency and poor appetite, milk stagnation, breast pain, weaning, liver depression and flank pain, and liver and stomach qi pain. Raw barley malt strengthens the spleen and stomach, soothes the liver and promotes qi. It is used for spleen deficiency and poor appetite, as well as milk stagnation. Roxburgh (Rosa roxburghii Tratt., Ros. Monogr.) is the fruit of the deciduous shrub Roxburgh in the Rosaceae family. It invigorates the spleen and digestion, relieves food stagnation, relieves fullness, and nourishes the kidneys. It is primarily used to invigorate the stomach and digest food, and treats food stagnation and distension.

[0017] Gout This prescription is caused by excessive drinking of alcohol, just as the "Saint Ji Zong Lu" said: "alcohol is the liquid of cooked grains, its nature is fierce and fast, after eating and entering, before eating and out, can pass through joints and run through the skin. In ancient times, it was made into soup, liquid and liquor, and was not used. In later generations, it was addicted to it without restraint, or drank too much, stopped and accumulated, stagnated in the stomach, scattered and flowed in the veins, smoked and steamed the viscera, made people's will confused, and even did not wake up, had no knowledge for several days, and even poisoned." The nature of alcohol is pungent and diffusing, easy to run and chase viscera, alcohol toxicity spreads, five internal organs are damaged, and this is a deficiency and excess syndrome, so it should be treated with internal and external differentiation, and the treatment of both the root and the branch. Alcohol toxicity is immersed and contaminated in the body, and cannot be discharged or dispersed, and wants to come out of the body and damage the five senses and nine orifices. Therefore, in the prescription, the root of kudzu vine is used as the monarch drug, which wakes up and dispels alcohol, and generates saliva to stop thirst; its nature is light and clear, and can make alcohol wet from the "surface" and be dispelled. "Food Materia Medica" records: "alcohol is used to release it, disorder its clarity and brightness, and strain the spleen and stomach." In the prescription, the "thousand cups do not get drunk" of the hovenia dulcis is used as the ministerial drug to dispel alcohol toxicity, stop thirst, remove restlessness, stop vomiting, and unblock the two excretory systems, so that alcohol toxicity is eliminated from the "inside", and the effect of "internal and external differentiation and elimination" is achieved. "Shou Shi Bao Yuan" says: "alcohol likes to rise, gas must follow up, phlegm stagnates in the upper, and phlegm stagnates in the lower." Therefore, the orange peel regulates qi and adjusts the middle, dries dampness and reduces phlegm; the yizhi-renal-warm-spleen and kidney, and solidify qi and essence; alcohol toxicity is accumulated in the middle, the spleen is stagnant, the spleen is stagnant, the liver is not smooth, the collaterals are not harmonious, and the qi movement is not smooth, so add malt to soothe the liver and regulate qi; to prevent excessive differentiation, use the sour and astringent rose to stop diarrhea and stop diarrhea, at the same time, increase the effect of dispelling alcohol with kudzu root and hovenia dulcis, and increase the effect of spleen and digestion with malt. The above four drugs can make the stomach and spleen, liver and kidney, and are used as auxiliary drugs. Looking at the whole prescription, differentiation and elimination are used, internal and external differentiation and elimination are used, elimination without damaging the normal, supporting without assisting the fullness, and the combined use of various drugs achieves the effects of eliminating alcohol toxicity, strengthening the spleen and eliminating accumulation, protecting the liver and kidney, removing restlessness and stopping vomiting, and astringent and stopping diarrhea, so that alcohol toxicity is eliminated, and various symptoms are harmonized. DETAILED DESCRIPTION

[0018] The application will be further described below in conjunction with examples, but it is not as the basis for limiting the application.

[0019] Example 1. 1. Prescription: Kudzu root 15g, hovenia dulcis 15g, orange peel 10g, yizhi 10g, raw malt 15g, rose 15g.

[0020] 2. Process: According to the prescription proportion, each medicinal material is weighed, crushed into coarse powder, soaked in 8 times the amount of water for 0.5 h, and decocted for 3 times, each time for 1 h. The three decocted liquids are combined, mixed uniformly, concentrated to 70% of the original medicinal liquid, filtered while hot, and concentrated to the extract with a relative density of 1.10-1.20 at 70°C. Then, 45% of the above extract is added with refined sugar, stirred uniformly, and heated to collect the extract. When a small amount of the extract can be drawn into silk or dropped on paper without water marks, the extract is filled into a sterile bottle and sealed to obtain the decocted extract.

[0021] Usage and dosage: orally taken, three times a day, 10-20 g each time.

[0022] Example 2. 1. Prescription: Pueraria 5 g, Hovenia dulcis Thunb. 50 g, Citrus reticulata 3 g, Alpinia oxyphylla 30 g, and Hordeum vulgare 5 g.

[0023] 2. Process: According to the prescription proportion, each medicinal material is weighed, soaked in 6 times the amount of water for 0.5 h, and decocted for 3 times, each time for 1.5 h. The three decocted liquids are combined, mixed uniformly, concentrated to 70% of the original medicinal liquid, filtered while hot, and concentrated to the extract with a relative density of 1.10-1.20 at 60°C. Then, 10% of ice sugar is added, stirred uniformly, and left for 24 h. After centrifugation and filtration, the filtrate is diluted with 1000 ml of distilled water and packaged to obtain the oral liquid.

[0024] Usage and dosage: orally taken, three times a day, 10-20 mL each time.

[0025] Example 3. 1. Prescription: Pueraria 50 g, Hovenia dulcis Thunb. 5 g, Citrus reticulata 30 g, Alpinia oxyphylla 3 g, and Hordeum vulgare 50 g.

[0026] According to the prescription proportion, each medicinal material is weighed, soaked in 10 times the amount of water for 0.5 h, and decocted for 2 times, each time for 1.5 h. The three decocted liquids are combined, mixed uniformly, concentrated to 70% of the original medicinal liquid, filtered while hot, and concentrated to the extract with a relative density of 1.10-1.20 at 70°C. Then, the extract is dried at 70°C to obtain dry extract, crushed into fine powder, and mixed with 10% of starch. The mixture is granulated with 75% ethanol, dried, and filled into capsules to obtain the hard capsule.

[0027] Usage and dosage: orally taken, three times a day, 3-5 capsules (0.5 g each) each time.

[0028] Example 4. 1. Prescription: Pueraria 48 g, Hovenia dulcis Thunb. 15 g, Citrus reticulata 20 g, Alpinia oxyphylla 3 g, and Hordeum vulgare 50 g.

[0029] 2. Process: According to the prescription proportion, each medicinal material is weighed, 12 times of water is added to soak for 0.5 h, and then decocted for 2 times, each time for 2 h. The three times of decocted liquid are combined, mixed, and concentrated to 70% of the original medicinal liquid. When hot, it is filtered, and the filtrate is concentrated to the relative density of 1.10-1.20 of the extract at 70°C. The extract is dried at 70°C, and pulverized into fine powder. The dry extract is obtained. The dry extract is taken, passed through a 16-mesh sieve, mixed with 0.5% of micronized silica gel and 1% of talc powder, pressed into tablets, and film-coated. The tablet is obtained.

[0030] Method of use and dosage: orally, three times a day, 3-5 tablets (0.5 g per tablet) each time.

[0031] Example 5. 1. Prescription: Pueraria 5 g, Hovenia dulcis Thunb. 20, Citrus reticulata 40 g, Alpinia oxyphylla 30 g, Hordeum vulgare 30 g, Malus sieversii 5 g.

[0032] 2. Process: According to the prescription proportion, each medicinal material is weighed, 8 times of water is added to soak for 0.5 h, and then decocted for 3 times, each time for 0.5 h. The three times of decocted liquid are combined, mixed, and concentrated to 70% of the original medicinal liquid. When hot, it is filtered, and the filtrate is concentrated to the relative density of 1.10-1.20 of the extract at 70°C. The extract is dried at 70°C, and pulverized into fine powder. The dry extract is obtained. The dry extract is taken, mixed with 20% of sucrose and 5% of dextrin, prepared into soft material, passed through a 16-mesh sieve, prepared into granules, and dried. The granules are obtained.

[0033] Method of use and dosage: orally, three times a day, 20 g each time.

Claims

1. A drug for sobering up and protecting the liver and a preparation method thereof, characterized by: The medicinal active ingredients are calculated by weight and are prepared from 50-500 parts of kudzu root, 50-500 parts of hovenia dulcis fruit, 30-300 parts of tangerine peel, 30-300 parts of alpinia oxyphylla kernel, 50-500 parts of raw malt and 50-500 parts of roxburghii.

2. The alcohol-relieving and liver-protecting drug according to claim 1 and its preparation method, characterized in that: The medicinal active ingredients are calculated by weight and are prepared from 100-200 parts of kudzu root, 100-200 parts of hovenia dulcis fruit, 50-150 parts of tangerine peel, 50-150 parts of alpinia oxyphylla kernel, 100-200 parts of raw malt and 100-200 parts of roxburghii.

3. The alcohol-relieving and liver-protecting drug according to claim 2 and its preparation method, characterized in that: The medicinal active ingredients are calculated by weight and are prepared from 150 parts of kudzu root, 150 parts of hovenia dulcis fruit, 100 parts of tangerine peel, 100 parts of alpinia oxyphylla kernel, 150 parts of raw malt and 150 parts of roxburghii.

4. A method for preparing the alcohol-relieving and liver-protecting drug according to any one of claims 1 to 3, characterized in that: The drugs in the prescription are combined with acceptable excipients in the drugs, processed according to conventional methods, and prepared into corresponding pharmaceutical preparations.

5. The method for preparing the alcohol-relieving and liver-protecting drug according to claim 4, characterized in that: The pharmaceutical preparation is a decoction, oral liquid, hard capsule, tablet or granule.

6. The method for preparing the alcohol-relieving and liver-protecting drug according to any one of claim 5, characterized in that: The decoction is prepared as follows: weigh each medicinal material according to the prescription ratio, grind it into coarse powder, add 8 times the amount of water to soak for 0.5h, and then boil it three times, each time for 1h, combine the three decoctions, mix them evenly, and concentrate them to 70% of the original medicinal solution, filter them while hot, and concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70°C. Take 45% of the weight of the above extract and slowly add refined sugar to the above extract, stir evenly, continue to heat over low heat to collect the paste, and when a small amount can be pulled into a thread or no water mark is left when dropped on paper, put it into a sterile bottle and seal it.

7. The method for preparing the alcohol-relieving and liver-protecting drug according to claim 5, characterized in that: The oral liquid is prepared as follows: weigh each medicinal material according to the prescription ratio, add 6 times the amount of water to soak for 0.5 hours, and then decoct for 3 times, each time for 1.5 hours, combine the three decoctions, mix them evenly, concentrate to 70% of the original medicinal solution, filter them while hot, concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 60° C., add 10% crystal sugar, stir evenly, let it stand for 24 hours, centrifuge, filter, dilute the filtrate with 1000 ml of distilled water, and encapsulate to obtain the oral liquid.

8. The method for preparing the alcohol-relieving and liver-protecting drug according to claim 5, characterized in that: The hard capsule is prepared as follows: weigh each medicinal material according to the prescription ratio, add 10 times the amount of water to soak for 0.5 hours, and then decoct twice, each time for 1.5 hours, combine the three decoctions, mix them evenly, concentrate to 70% of the original medicinal solution, filter them while hot, concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70° C., dry it at 70° C. to obtain a dry extract, grind it into fine powder, add 10% of the preparation amount of starch, mix evenly, granulate with 75% ethanol, dry it, shape the granules, and fill them into capsules to obtain the hard capsule.

9. The method for preparing the alcohol-relieving and liver-protecting drug according to claim 5, characterized in that: The tablets are prepared as follows: weighing each medicinal material according to the prescription ratio, adding 12 times the amount of water to soak for 0.5h, and then decocting twice, each time for 2h, combining the three decoctions, mixing, and concentrating to 70% of the original medicinal solution, filtering while hot, and concentrating the filtrate to an extract with a relative density of 1.10-1.20 at 70°C. The extract is dried at 70°C and crushed into fine powder to obtain a dry extract. The dry extract is taken, passed through a 16-mesh sieve, added with 0.5% micro-powder silica gel and 1% talcum powder, mixed, tableted, and film-coated to obtain the tablets.

10. The method for preparing the alcohol-relieving and liver-protecting drug according to claim 5, characterized in that: The granules are prepared as follows: weigh each medicinal material according to the prescription ratio, add 8 times the amount of water to soak for 0.5h, and then boil three times, each time for 0.5h, combine the three decoctions, mix them evenly, concentrate to 70% of the original medicinal solution, filter them while hot, concentrate the filtrate to an extract with a relative density of 1.10-1.20 at 70°C, dry the extract at 70°C, and grind it into fine powder to obtain a dry extract, take the dry extract, add 20% sucrose and 5% dextrin, mix them, make them into a soft material, pass them through a 16-mesh sieve, make them into granules, and dry them to obtain the granules.