Anti-aging repairing composition as well as preparation method and application thereof

Abstract

The invention relates to the field of cosmetics, in particular to an anti-aging repairing composition as well as a preparation method and application thereof. The anti-aging repairing composition is obtained by compounding ALEURIES MOLUCCANA seed oil, lupinus albus seed oil and phytol, all the components have a synergistic effect, the anti-aging repairing composition has anti-aging and repairing dual effects, the problems that a pure oil system is poor in single active matter effect and large in irritation can be solved, the anti-aging repairing composition can be applied to cosmetics, and the anti-aging repairing composition has a good application prospect. And a new choice is provided for the development of oil-soluble anti-aging repair products.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to an anti-aging care composition and a preparation method and application thereof. BACKGROUND

[0002] With the increasing pursuit of skin health and youth, skin care products with oil-soluble system as the matrix are favored in the cosmetic market due to their good skin affinity, penetration and nourishing effect. This system can effectively simulate the skin lipid structure and provide a natural protective barrier for the skin, and is suitable for the care of different skin. However, the current skin care products of this type still face many challenges in the application of active ingredients.

[0003] For example, the single efficacy defect: traditional oil-soluble active substances (such as retinol derivatives, phytosterols) usually only target a single pathway (such as collagen regeneration or antioxidant), making it difficult to achieve multiple effects such as anti-wrinkle and repair at the same time, resulting in the need for consumers to use multiple products; single active substances cannot meet the multiple needs of skin anti-aging and repair, and cannot achieve multi-dimensional and multi-level skin care effects, resulting in limited skin care effects. High-concentration single active substances are prone to aggregation, causing strong irritation to the skin, leading to redness, itching, and desquamation, especially poor suitability for sensitive skin, affecting user experience and skin health. Compounding different oil active substances may result in poor solubility, stability and compatibility, making it difficult for different active substances to disperse uniformly in pure oil matrix, resulting in problems such as stratification and precipitation in the compounded system, greatly reducing product quality and efficacy, and making it difficult to meet the urgent needs of consumers for efficient and mild skin care products. SUMMARY

[0004] The present application aims to overcome the deficiencies in the prior art and provide an anti-aging care composition.

[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present application is as follows:

[0006] In a first aspect, the present application provides an anti-aging care composition comprising the following components by weight: Aleurites moluccana seed oil 0.5-1 parts, Lupinus albus seed oil 0.3-0.5 parts, phytol 0.3-1 part.

[0007] The stone chestnut seed oil contains rich polyphenol components and has strong antioxidant effect, and the white lupin seed oil is rich in sterol, tocopherol and unsaponifiable matter and the like, has good scavenging effect on free radicals caused by UV and can inhibit lipid peroxidation. The phytol can neutralize oxidizable anions by releasing protons from alcohol (OH) groups, so as to achieve the effect of scavenging free radicals. The stone chestnut (ALEURITES MOLUCCANA) seed oil, the white lupin (Lupinus Albus) seed oil and the phytol are compounded to obtain an anti-aging and repair composition, which has dual effects of anti-aging and repair. The components are compounded in a specific ratio to prepare the anti-aging and repair composition, and the components play a synergistic effect, so that the composition has the effects of anti-aging and repair, thereby improving skin problems in all directions. The anti-aging and repair composition mainly contains oil-soluble active substances. The phytol is a terpene component, and the addition of the phytol in the application not only has good penetration effect and can solve the problem of poor penetration effect of active substances, but also improves the repair effect of the composition. The phytol is converted into phytanic acid after entering the skin, can activate the RAR signal pathway to promote the differentiation of the epidermis, that is, promote the metabolism of the epidermis, can promote the expression of collagen, and can also activate the PPAR signal pathway to promote the secretion of barrier lipids (ceramides, sterols and the like), so as to achieve the effect of repair.

[0008] Preferably, the components include the following weight parts: 0.5 parts of stone chestnut (ALEURITES MOLUCCANA) seed oil, 0.5 parts of white lupin (Lupinus Albus) seed oil and 0.5 parts of phytol.

[0009] Preferably, the anti-aging and repair composition further includes the following weight parts of components: 10-20 parts of isononyl isononanoate, 10-15 parts of squalane, 5-10 parts of coceth- octanoate / decanoate, 0.1-1 part of tocopheryl acetate and isododecane to make up to 100 parts.

[0010] The anti-aging and repair composition obtained by adding base oil and stabilizer to the anti-aging and repair composition has a sticky skin feel, and the tocopheryl acetate can improve the stability of the composition and prevent oxidation and deterioration.

[0011] In the second aspect, the application provides a preparation method of the anti-aging and repair composition, which includes the following steps:

[0012] (1) mixing and stirring isododecane, isononyl isononanoate, squalane, coceth-octanoate / decanoate and tocopheryl acetate to obtain a mixture A;

[0013] (2) mixing and stirring Aleurites moluccana seed oil, Lupinus Albus seed oil and phytol uniformly to obtain mixture B;

[0014] (3) mixing and stirring mixture A and mixture B uniformly to obtain the anti-aging and repairing composition.

[0015] In a third aspect, the present application provides application of the anti-aging and repairing composition in preparing anti-aging and repairing cosmetics.

[0016] Preferably, the type of the anti-aging and repairing cosmetics includes oil-soluble cosmetics.

[0017] In a fourth aspect, the present application provides an anti-aging and repairing cosmetic comprising the anti-aging and repairing composition.

[0018] Preferably, the anti-aging and repairing composition is added in an amount of 0.1%-3% of the total mass of the anti-aging and repairing cosmetic.

[0019] The present application has the following advantages:

[0020] The present application provides an anti-aging and repairing composition by compounding Aleurites moluccana seed oil, Lupinus Albus seed oil and phytol, which has the synergistic effect of the components and the dual effects of anti-aging and repairing, can solve the problem of poor effect and high irritation of pure oil system, and can be applied to cosmetics, thereby providing a new choice for the development of oil-soluble anti-aging and repairing products. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 The result graph of the change rate of the water content of the stratum corneum of the subject using different test samples.

[0022] Figure 2 The result graph of the change rate of the transdermal water loss of the subject using different test samples. DETAILED DESCRIPTION

[0023] For the purpose of better illustrating the present application, technical solutions and advantages, the present application will be further described in combination with specific examples. The examples listed in the specification are only preferred embodiments of the present application, and cannot limit the scope of the present application. Any substantial modification and replacement made by those skilled in the art on the basis of the present application shall fall within the scope of the present application.

[0024] Unless otherwise specified, the raw materials used in the present application are all conventional commercially available products.

[0025] The appearance of the composition prepared by the present application is: yellow transparent oily liquid; heat resistance (45±2℃): 3 months, restore room temperature, no abnormality; cold resistance (-18±2℃): 3 months, restore room temperature, no abnormality; cycle test (45℃, room temperature, -18℃): 3 months, restore room temperature, no abnormality.

[0026] The Aleurites moluccana seed oil is purchased from Guangzhou Feike Biological Technology Co., Ltd.

[0027] The Lupinus Albus seed oil is purchased from Guangzhou Aoyuan Trade Co., Ltd.

[0028] The phytol is purchased from Suzhou Nakang Biological Technology Co., Ltd.

[0029] The coco-caprylate / caprate, CAS:95912-86-0, is purchased from Foshan Xin'an Chemical Trade Co., Ltd.

[0030] Examples 1-4:

[0031] The anti-aging protective composition of the present application; the anti-aging protective composition of examples 1-4 contains components and their proportions as shown in Table 1.

[0032] Table 1 Anti-aging protective composition of examples 1-4 (unit: part)

[0033]

[0034] The preparation method of the anti-aging protective composition includes the following steps:

[0035] 1. Accurately weigh each component, and clean the production equipment at the same time;

[0036] 2. Add isododecane, isononyl isononanoate, squalane, coco-caprylate / caprate, and tocopheryl acetate into the reaction kettle in turn, start stirring at 10-20 rpm, and stir for 10-15 min to obtain mixture A;

[0037] 3. Mix Aleurites moluccana seed oil, Lupinus Albus seed oil, and phytol uniformly to obtain mixture B;

[0038] 3. Add mixture B to mixture A in the reaction kettle, and stir for 10-15 min to obtain the anti-aging protective composition.

[0039] Comparative examples 1-7:

[0040] The anti-aging protective composition of the present application; the anti-aging protective composition of examples 1-4 contains components and their proportions as shown in Table 1.

[0041] Table 2 Comparative Example 1-7 Anti-aging care composition (unit: parts)

[0042]

[0043]

[0044] Among them, Comparative Example 1 does not add Aleurites moluccana seed oil, Comparative Example 2 does not add Lupinus Albus seed oil, and Comparative Example 3 does not add phytol.

[0045] The difference between Comparative Example 4 and Example 4 is only that Comparative Example 4 replaces the Aleurites moluccana seed oil in Example 4 with an equal weight part of white pool flower seed oil;

[0046] The difference between Comparative Example 5 and Example 4 is only that Comparative Example 5 replaces the Lupinus Albus seed oil in Example 4 with an equal weight part of oil-soluble palmitoyl tripeptide-1.

[0047] The difference between Comparative Example 6 and Example 4 is only that Comparative Example 6 replaces the phytol in Example 4 with an equal weight part of hydroxyl pinacolyl ketone retinoate.

[0048] The preparation method of the anti-aging care composition is the same as that of Examples 1-4.

[0049] Test Example 1: Antioxidant test

[0050] Test sample: Anti-aging care compositions prepared by Examples 1-4 and Comparative Examples 1-7.

[0051] This test example detects the free radical scavenging ability of the test sample. The test method refers to “T / SHRH 006-2018, Cosmetics - Free radical (DPPH) scavenging experimental method”.

[0052] Specific experimental process:

[0053] 1. Prepare a 0.1 mmol / L DPPH solution (1 mg DPPH dissolved in 24 mL anhydrous ethanol) with anhydrous ethanol, ultrasonic for 5 min, shake well, avoid light, and use within 5 h.

[0054] 2. Add 2 mL of test sample solution (sample dissolved in anhydrous ethanol) and 2 mL of DPPH solution into the same test tube, shake well, and measure the absorbance Asample after 30 min of standing in the dark at room temperature. Repeat 3 times, mark as A1, A2, A3, and take the average value. At the same time, measure the absorbance A0 of the mixture of 2 mL DPPH solution and 2 mL ethanol, and determine the blank group. Repeat 3 times, take the average value.

[0055] 3. Calculate the DPPH free radical scavenging rate according to the following formula:

[0056] DPPH free radical scavenging rate (%) = (A0-Asample) / A0×100%.

[0057] In the above formula, A0 is the absorbance of DPPH at 520 nm without sample; Asample is the absorbance of DPPH at 520 nm with sample added. The test results are shown in Table 3.

[0058] Table 3

[0059]

[0060] From the experimental results in the above table, it can be seen that the anti-aging repair compositions prepared in the examples and comparative examples all have certain antioxidant effects, but the antioxidant effects of the anti-aging repair compositions of Examples 1-4 are significantly better than those of the anti-aging repair compositions of Comparative Examples 1-7. This shows that the anti-aging repair compositions obtained by compounding Aleurites moluccana seed oil, Lupinus albus seed oil, and phytol in the present invention are coordinated with each other and have a synergistic effect. Although Aleurites moluccana seed oil and Lupinus albus seed oil have certain anti-aging effects, their effects are single. The present invention further adds phytol, whose diterpenoid structure helps the absorption of the active ingredients in the composition, so that the anti-aging repair composition has a stronger repair effect.

[0061] Compared with the anti-aging repair compositions of Examples 1-4, the anti-oxidation effect of Example 4 is the best, with obvious anti-oxidation effect, capable of resisting the damage of free radicals to the skin, and achieving better anti-aging effect.

[0062] Test Example 2: Skin Firmness Test

[0063] Test samples: anti-aging repair compositions prepared in Examples 1-4 and Comparative Examples 1-7.

[0064] Testing Principle: This test uses the Cutometer dual MPA580 skin elasticity tester to measure skin firmness. Firm skin indicates elasticity and collagen production. Increases and decreases in skin firmness are closely related to skin elasticity and collagen content. When skin becomes loose and collagen is lost, the skin firmness value increases. When skin becomes elastic and collagen-rich, the skin firmness value decreases. The MPA580 measures the skin firmness RO value, which reflects the skin's passive response to external forces. A lower R0 value indicates firmer skin.

[0065] Test environment: temperature 22±1℃, humidity 50±5%, and real-time dynamic detection.

[0066] Test volunteers: aged 30-45 years old (except pregnant or lactating women), without serious systemic diseases, without immunodeficiency or autoimmune diseases; no history of serious allergy to skin care cosmetics; no use of hormone drugs and immunosuppressants in the past month; no participation in other clinical trials; use of test drugs as required and complete data; all volunteers filled in the informed consent form before the test. The test site was not used with any product (cosmetics or external drugs) for 2-3 days before the test.

[0067] Test process: 5 people were randomly assigned to each test sample, and the subjects were cleaned in the constant temperature and humidity chamber. The facial skin tightness of the subjects was measured as the original value. Then, according to the daily use habit, the product was applied to the whole face, gently massaged until completely absorbed, and then the product use instruction was issued and the product was used for subsequent use. The subjects needed to use it once a day in the morning and evening, for 28 days, and then returned to the laboratory for retesting. The test of the same volunteer was completed by the same measurer.

[0068] The measurement parameters were set as: ON-TIME: 1.0S, OFF-TIME: 1.0S, Pressure: 450 mbar, Repetition: 10, and the average value of 5 people in each group was taken for each test.

[0069] The skin tightness improvement rate was calculated according to the following formula.

[0070] Skin tightness improvement rate R (%) = (R02-R01) / R01x100%

[0071] In the above formula, R is the skin tightness improvement rate, %; R01 is the original value of skin tightness before using the sample; R02 is the skin tightness after continuous use of the sample for 28 days. The test results are shown in Table 4.

[0072] Table 4

[0073] Test sample R01 R02 R％ Example 1 0.21 0.17 -19.05 Example 2 0.20 0.16 -20.00 Example 3 0.24 0.18 -25.00 Example 4 0.26 0.18 -30.77 Comparative Example 1 0.25 0.23 -8.00 Comparative Example 2 0.17 0.15 -11.76 Comparative Example 3 0.18 0.16 -11.11 Comparative Example 4 0.20 0.17 -15.00 Comparative Example 5 0.22 0.19 -13.64 Comparative Example 6 0.2 0.17 -15.00 Comparative Example 7 0.16 0.13 -18.75

[0074] The anti-aging effects of the anti-aging care compositions of Examples 1-4 were compared, and the anti-aging effect of Example 4 was the best. From the comparison of the anti-aging effects of the anti-aging care compositions of Example 4 and Comparative Examples 1-7, it can be seen that there is a synergistic effect among the three of candlenut seed oil, white lupin seed oil and phytol, and the anti-aging and tightening effect.

[0075] Test Example 3: Evaluation of Skin Moisturizing and Care Efficacy

[0076] Test samples: Anti-aging care compositions prepared from Examples 1-4 and Comparative Examples 1-7.

[0077] This test example detects the repair efficacy of the test sample. The rate of change of the stratum corneum moisture content and the trans-epidermal water loss (TEWL) value of the subjects before and after using the sample are tested by the cosmetic influence on skin moisture content and trans-epidermal water loss test method, so as to evaluate the repair effect of the sample in improving the skin barrier function.

[0078] Test method:

[0079] Select subjects aged 20-50 years old, allocate 6 people to test each test sample, and the subjects should not use other similar cosmetics before the experiment. After cleansing in the morning and evening, take about 1 g of sample, lightly pat on the face until absorbed, and use it once in the morning and evening, for 28 consecutive days. Record the skin moisture content and trans-epidermal water loss values on D0, D14, and D28.

[0080] 1. Skin moisture content

[0081] Test the skin moisture content of the subjects before and after using the sample. Record the skin moisture content on D0, D14, and D28, and test the stratum corneum moisture content using the skin moisture tester Corneometer CM825. Calculate the moisture content ratio according to the following formula:

[0082] Moisture content ratio (%) = (DX-D0) / D0x100% (X represents the number of days tested)

[0083] The results are shown in Table 5. Figure 1

[0084] Table 5

[0085]

[0086] From the experimental results in Table 5, it can be seen that the anti-aging repair compositions prepared in the examples and comparative examples have certain effect on increasing the stratum corneum moisture content. The larger the value, the higher the water content of the skin.

[0087] 2. Trans-epidermal water loss

[0088] Test the trans-epidermal water loss of the subjects before and after using the sample. Record the trans-epidermal water loss values of the skin on D0, D14, and D28, respectively, and measure them using the trans-epidermal water loss tester Tewameter TM300. The results are shown in Table 6. Figure 2

[0089] Table 6

[0090]

[0091] ​​

[0092] Test Example 4: Safety Evaluation Test

[0093] Test Sample: Anti-aging protective compositions prepared in Examples 1-4. The sample safety was evaluated using human patch test.

[0094] Test Method: 30 people were selected for each sample group, and the specific gender composition and age composition were randomly determined (in line with the inclusion and exclusion criteria of the "Diagnosis Standard and Handling Principle of Contact Dermatitis of Cosmetics"). The sample was placed in the patch tester (sample amount was 0.020-0.025 g), the control hole was blank (without any substance), and the sample and blank control were both attached to the flexor of the forearm of the test subject, and the palm was gently pressed to make it evenly attached to the skin for 24 h. After 30 min of removing the patch tester, the skin reaction was observed after the indentation disappeared. If the result was negative, it was observed again at 24 h and 48 h, respectively.

[0095] According to the "Diagnosis Standard and Handling Principle of Contact Dermatitis of Cosmetics", the classification determination criteria are shown in Table 7. The evaluation criteria are that the number of people with grade 1 skin adverse reactions in 30 test subjects after 24 h of patch test is more than 5, or the number of people with grade 2 skin adverse reactions is more than 2, or any 1 case of grade 3 or above skin adverse reactions occurs, then the test substance is determined to have skin adverse reactions on the human body.

[0096] Table 7 Skin reaction grading criteria for skin occlusive patch test

[0097]

[0098]

[0099] Table 8 Patch test results

[0100]

[0101] The patch test results are shown in Table 8. The anti-aging protective compositions prepared in Examples 1-4 all passed the patch test, and were determined to have no adverse reactions on human skin.

[0102] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application and not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.

Claims

1. An anti-aging repair composition, characterized in that: The invention comprises the following components in parts by weight: 0.5-1 part of Aleurites moluccana seed oil, 0.3-0.5 part of Lupinus albus seed oil and 0.3-1 part of phytol.

2. The anti-aging repair composition according to claim 1, wherein The invention comprises the following components in parts by weight: 0.5 part of Aleurites moluccana seed oil, 0.5 part of Lupinus albus seed oil and 0.5 part of phytol.

3. The anti-aging repair composition according to claim 1, wherein The anti-aging repair composition further comprises the following components in parts by weight: 10-20 parts of isononyl isononanoate, 10-15 parts of squalane, 5-10 parts of coconut oil caprylate / caprate, 0.1-1 part of tocopheryl acetate, and isododecane to make up to 100 parts.

4. The method for preparing the anti-aging repair composition according to any one of claims 1 to 3, wherein: The steps include: (1) isododecane, isononyl isononanoate, squalane, coconut oil alcohol caprylate / caprate, and tocopheryl acetate are mixed and stirred to obtain a mixture A; (2) mixing and stirring the Aleurites moluccana seed oil, the white lupin (Lupinus albus) seed oil, and the phytol to obtain a mixture B; (3) Mixing mixture A and mixture B is stirred and mixed uniformly to obtain the anti-aging repair composition.

5. Use of the anti-aging repairing composition according to any one of claims 1 to 3 in the preparation of anti-aging repairing cosmetics.

6. The use according to claim 5, characterized in that The types of the anti-aging repair cosmetics include oil-soluble cosmetics.

7. An anti-aging and repairing cosmetic, characterized in that: The invention comprises the anti-aging repair composition according to any one of claims 1 to 3.

8. The anti-aging repair cosmetic according to claim 7, characterized in that: The added amount of the anti-aging repair composition is 0.1%-3% of the total mass of the anti-aging repair cosmetic.

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