Nutritional composition for improving nausea and vomiting in gestation period and guaranteeing growth and development of fetuses

Abstract

The invention relates to a nutritional composition for improving nausea and vomiting in a gestation period and guaranteeing growth and development of fetuses. The health-care food is prepared from the following components in percentage by mass: 10.68 percent to 24.05 percent of carbohydrate, 17.93 percent to 36.41 percent of protein substances, 20.9 percent to 52.94 percent of fat substances, 8.55 percent to 18.37 percent of dietary fiber substances, 1.11 percent to 1.35 percent of compound vitamins, 11.17 percent to 37.27 percent of compound minerals and 1.20 percent to 2.38 percent of blueberry powder. According to the nutritional composition, various nutrients are reasonably matched and the content of each nutrient is regulated and controlled, under the synergistic effect of the nutrients, the attack frequency of nausea and vomiting in the gestation period can be remarkably reduced, nutrients needed in the gestation period can be comprehensively supplemented, the nutrition gap of pregnant women caused by vomiting is complemented, and the nutritional value of the pregnant women is improved. The feed meets the requirements of pregnant women during pregnancy, guarantees normal growth and development of fetuses, and is especially suitable for pregnant women with nausea and vomiting symptoms and needing nutrition support, so as to improve the health level of mothers and infants.

Description

Technical Field

[0001] The present invention relates to the technical field of nutritional foods, and in particular to a nutritional composition for improving nausea and vomiting during pregnancy and ensuring fetal growth and development. Background Art

[0002] Nausea and vomiting of pregnancy (NVP) is one of the most common clinical symptoms of early pregnancy, affecting approximately 50%-80% of pregnant women, of whom approximately 0.3%-3% may develop hyperemesis gravidarum (HG). Due to factors such as hormonal fluctuations and mood swings during pregnancy that affect digestive system function, pregnant women may experience a poor appetite and food sensitivities, leading to persistent vomiting and eating disorders, and subsequently complications such as dehydration, electrolyte imbalance, and ketoacidosis. These symptoms not only severely impact the mother's quality of life but may also result in insufficient fetal nutrition, increasing the risk of adverse pregnancy outcomes such as premature birth and low birth weight.

[0003] Current clinical treatment mainly relies on symptomatic treatment with antihistamines, but long-term use is controversial in terms of safety and cannot solve the core problem of nutritional deficiency; non-drug measures such as dietary adjustments are not effective in improving moderate to severe symptoms.

[0004] Based on this, there is an urgent need for a nutritional composition that can effectively relieve nausea and vomiting during pregnancy, provide nutritional support, and ensure fetal growth and development, so as to improve the health of mothers and babies. Summary of the Invention

[0005] To solve the above problems, the present invention provides a nutritional composition for improving nausea and vomiting during pregnancy and ensuring fetal growth and development. By scientifically proportioning multiple nutrients, it can effectively improve nausea and vomiting during pregnancy, supplement the nutrients required during pregnancy to ensure normal growth and development of the fetus.

[0006] Specifically, the present invention provides the following technical solutions:

[0007] The present invention provides a nutritional composition for improving nausea and vomiting during pregnancy and ensuring fetal growth and development, comprising the following ingredients by mass percentage: 10.68%-24.05% of carbohydrates, 17.93%-36.41% of protein substances, 20.9%-52.94% of fat substances, 8.55%-18.37% of dietary fiber substances, 1.11%-1.35% of complex vitamins, 11.17%-37.27% of complex minerals, and 1.20%-2.38% of blueberry powder;

[0008] The carbohydrates include maltodextrin, corn syrup solids;

[0009] The protein substances include whey protein, soy protein, sodium caseinate, and collagen peptide;

[0010] The fatty substances include DHA algae oil, medium chain triglycerides, sunflower oil and linseed oil;

[0011] The dietary fiber substances include resistant dextrin and isomaltooligosaccharide.

[0012] For pregnant women who need nutritional support, especially those with symptoms of hyperemesis gravidarum, the present invention rationally combines multiple nutrients and regulates the content of each nutrient. Under the synergistic effect of each nutrient, the prepared nutritional composition can significantly reduce the frequency of nausea and vomiting during pregnancy. It can also comprehensively supplement the nutrients required during pregnancy, make up for the nutritional gap caused by vomiting, meet the needs of pregnant women during pregnancy, and ensure the normal growth and development of the fetus. Specifically:

[0013] The present invention adds an appropriate amount of maltodextrin and solid corn syrup to the nutritional composition, which can quickly provide energy for pregnant women as easily digestible carbohydrates. Compared with single maltodextrin (which can quickly provide energy but will cause blood sugar fluctuations), solid corn syrup is digested more slowly due to the presence of some polysaccharides, and can smoothly provide energy while having less effect on blood sugar. Under the synergistic effect of the two, the fluidity and sweetness of the powder can be taken into account, and the impact on blood sugar can be reduced while providing matrix energy. The above-mentioned nutritional composition also contains an appropriate amount of specific types of protein substances, which can provide essential amino acids to support fetal tissue development and maternal needs. Among them, whey protein is a high-quality protein that is quickly absorbed and rich in branched-chain amino acids, which can efficiently stimulate protein synthesis; soy protein is a complete plant protein that contains essential amino acids for the human body and is rich in plant active ingredients such as isoflavones; sodium caseinate has a sustained-release absorption characteristic and can provide a continuous supply of amino acids; the unique glycine-proline-hydroxyproline sequence of collagen peptides can support the repair of skin, joints and connective tissues, and has high bioavailability. The above four proteins complement each other in terms of digestion and absorption rate, amino acid spectrum, and functional characteristics. They can not only stabilize blood sugar, prolong satiety, reduce nausea caused by fasting, but also enhance immunity during pregnancy.

[0014] In addition, the present invention adds an appropriate amount of fat substances including DHA algae oil, medium-chain triglycerides, sunflower oil and linseed oil to the nutritional composition. On the one hand, the introduction of DHA algae oil can reduce gastrointestinal discomfort caused by inflammation and support fetal neurodevelopment; medium-chain triglycerides can quickly provide energy and are easy to digest, and are suitable for energy replenishment after vomiting; the addition of sunflower oil and linseed oil can provide α-tocopherol and α-linolenic acid with antioxidant and anti-inflammatory effects, thereby reducing the incidence of infection during pregnancy. And the present invention introduces an appropriate amount of dietary fiber substances including resistant dextrin and oligosaccharide into the nutritional composition, wherein resistant dextrin has a low glycemic index, can stabilize blood sugar levels, promote intestinal peristalsis, relieve constipation, and also has the effects of increasing satiety and promoting mineral absorption; oligosaccharide can play a prebiotic role and can effectively promote the growth and reproduction of bifidobacteria; these two dietary fibers have good stability, and the two are synergistically beneficial to delay gastric emptying, promote the proliferation of probiotics and the production of short-chain fatty acids to improve intestinal microecology, thereby relieving gastrointestinal discomfort, and the tolerance dose of pregnant women is higher, and it is not easy to cause flatulence and diarrhea. In addition, the addition of an appropriate amount of compound vitamins and compound minerals can provide pregnant women with the required vitamins and minerals, improve maternal appetite and digestion and absorption, and alleviate vomiting symptoms and gastrointestinal discomfort associated with vomiting. In addition to the above ingredients, the present invention adds an appropriate amount of blueberry powder, which utilizes its antioxidant protection effect to neutralize free radicals, reduce the damage of oxidative stress to the mother and fetus, inhibit excessive inflammation, and reduce the incidence of infection during pregnancy. At the same time, its unique sweet and sour flavor and fruity aroma can effectively improve taste sensitivity during pregnancy.

[0015] With the synergistic effect of the above-mentioned ingredients in appropriate amounts, it can effectively improve nausea and vomiting during pregnancy, supplement the nutrients needed during pregnancy, and ensure the normal growth and development of the fetus.

[0016] Furthermore, the mass percentages of maltodextrin and solid corn syrup in the carbohydrates in the nutritional composition are 7.06%-14.35% and 3.62%-9.70%, respectively. Maltodextrin and solid corn syrup, as easily digestible carbohydrates, mainly play a role in rapid energy supply. Among them, maltodextrin has high solubility and low viscosity, which helps to improve the fluidity of the composition powder, but may cause blood sugar fluctuations. Solid corn syrup dissolves slightly slower, but can provide a mild sweetness. In addition, solid corn syrup is digested more slowly due to the presence of some polysaccharides, which can provide energy smoothly and has little effect on blood sugar. In order to take into account the fluidity and sweetness of the powder, provide matrix energy while reducing the impact on blood sugar, preferably, the mass percentages of maltodextrin and solid corn syrup in the nutritional composition are controlled in the ranges of 7.06%-14.35% and 3.62%-9.70%, respectively.

[0017] Furthermore, the mass percentages of whey protein, soy protein, sodium caseinate, and collagen peptide in the protein substances in the nutritional composition are 11.93%-24.02%, 2.03%-4.24%, 1.99%-4.70%, and 1.99%-3.45%, respectively. As mentioned above, high-quality proteins such as whey protein and soy protein provide essential amino acids to support fetal tissue development and maternal needs, and different protein substances differ in digestion and absorption, the types of amino acids provided, and the effects of their effects. By introducing the above four Protein substances and controlling the mass proportion of each protein substance in the nutritional composition. Preferably, the mass percentages of whey protein, soy protein, sodium caseinate and collagen peptide in the nutritional composition are controlled in the ranges of 11.93%-24.02%, 2.03%-4.24%, 1.99%-4.70% and 1.99%-3.45%, respectively, so that the four proteins can complement each other in terms of digestion and absorption rate, amino acid spectrum and functional properties, so as to simultaneously meet multiple needs such as rapid energy supply, sustained release, cardiovascular protection and tissue repair.

[0018] Furthermore, the mass percentages of DHA algae oil, medium-chain triglycerides, sunflower oil, and linseed oil in the fat substances in the nutritional composition are 0.29%-0.65%, 7.41%-12.90%, 5.23%-7.13%, and 2.43%-4.89%, respectively. By adding appropriate amounts of DHA algae oil, medium-chain triglycerides, sunflower oil, and linseed oil, energy supplementation is provided while helping to improve the resistance of pregnant women, reduce gastrointestinal discomfort caused by inflammation, and is beneficial to the neural development of the fetus.

[0019] Furthermore, the mass percentages of resistant dextrin and oligosaccharide in the dietary fiber substances in the nutritional composition are 6.81%-13.59% and 1.74%-4.78%, respectively. The two dietary fibers have different functions. The two are synergistic and beneficial to delay gastric emptying, promote the proliferation of probiotics and the production of short-chain fatty acids to improve intestinal microecology and relieve gastrointestinal discomfort. Using only one dietary fiber or too little of a certain dietary fiber will lose functional diversity. Preferably, the mass percentages of resistant dextrin and oligosaccharide in the nutritional composition are controlled in the ranges of 6.81%-13.59% and 1.74%-4.78%, respectively.

[0020] Furthermore, the fat substance further comprises an edible carrier; the edible carrier comprises one or more of maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate, and mixed tocopherol concentrate.

[0021] In some preferred embodiments, the edible carrier comprises maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate and mixed tocopherol concentrate, and the mass percentages of maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate and mixed tocopherol concentrate in the fat substance in the nutritional composition are 2.61%-4.54%, 0.94%-2.71%, 0.26%-0.40%, 0.15%-0.40%, 0.05%-0.11% and 0.01%-0.03%, respectively.

[0022] Furthermore, the compound vitamins include vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12 and sodium L-ascorbate; preferably, the compound vitamins include vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12 and sodium L-ascorbate in the nutritional composition. The mass percentages are 0.012%-0.046%, 0.007%-0.019%, 0.078%-0.132%, 0.002%-0.008%, 0.007%-0.011%, 0.004%-0.012%, 0.029%-0.064%, 0.022%-0.051%, 0.008%-0.013%, 0.008%-0.018%, 0.008%-0.020%, 0.006%-0.014%, and 0.375%-0.853% respectively.

[0023] The addition of complex vitamins to nutritional compositions can provide pregnant women with the vitamins they need. By regulating the types and amounts of these vitamins, the nutritional compositions can further optimize their effects on suppressing vomiting in pregnant women and promoting nutrient absorption and fetal growth and development. For example, the synergistic effects of B vitamins, such as vitamin B1, B2, B3, B5, B6, B7, B9, and B12, can optimize energy metabolism, improve maternal appetite and digestion, and supplement folic acid can help reduce the risk of neural tube defects in the fetus. Furthermore, vitamin D3 helps regulate calcium balance and immune homeostasis.

[0024] Furthermore, the vitamin complex further comprises maltodextrin as an edible carrier; in some preferred embodiments, the mass percentage of maltodextrin as an edible carrier in the vitamin complex in the nutritional composition is 0.310%-0.643%.

[0025] Furthermore, the complex minerals include tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate and sodium selenite; more preferably, the mass percentages of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate and sodium selenite in the complex minerals in the nutritional composition are 2.41%-5.87%, 0.10%-0.32%, 1.80%-6.11%, 4.20%-5.76%, 0.09%-0.21%, 3.78%-12.31%, 0.05%-0.13% and 0.02%-0.04%, respectively.

[0026] Complex minerals provide pregnant women with morning sickness symptoms with the necessary mineral elements to improve nausea and vomiting during pregnancy. For example, magnesium can relieve smooth muscle spasms and reduce gastrointestinal discomfort associated with vomiting. Zinc helps pregnant women tolerate food by maintaining taste sensitivity and digestive enzyme activity. Sodium and potassium can improve dehydration and electrolyte disorders caused by frequent vomiting.

[0027] Furthermore, the complex minerals further comprise maltodextrin as an edible carrier; in some preferred embodiments, the mass percentage of the edible carrier maltodextrin in the complex minerals in the nutritional composition is 0.80%-2.19%.

[0028] Furthermore, according to the mass percentage of each component in the nutritional composition,

[0029] The carbohydrates are composed of 7.06%-14.35% maltodextrin and 3.62%-9.70% solid corn syrup;

[0030] The protein material is composed of 11.93%-24.02% whey protein, 2.03%-4.24% soy protein, 1.99%-4.70% sodium caseinate and 1.99%-3.45% collagen peptide;

[0031] The fatty substance consists of 0.29%-0.65% DHA algae oil, 7.41%-12.90% medium chain triglycerides, 5.23%-7.13% sunflower oil, 2.43%-4.89% flaxseed oil, 2.61%-4.54% maltooligosaccharides, 0.94%-2.71% sodium caseinate, 0.26%-0.40% silicon dioxide, 0.15%-0.40% mono- and diglycerides of fatty acids, 0.05%-0.11% sodium tripolyphosphate and 0.01%-0.03% mixed tocopherol concentrate;

[0032] The dietary fiber substance is composed of 6.81%-13.59% resistant dextrin and 1.74%-4.78% isomaltooligosaccharide;

[0033] The compound vitamin comprises 0.012%-0.046% vitamin A palmitate, 0.007%-0.019% vitamin D3, 0.078%-0.132% vitamin E acetate, 0.002%-0.008% vitamin K1, 0.007%-0.011% thiamine hydrochloride, 0.004%-0.012% vitamin B2, 0.029%-0.064% Nicotinamide, 0.022%-0.051% D-calcium pantothenate, 0.008%-0.013% pyridoxine hydrochloride, 0.008%-0.018% biotin, 0.008%-0.020% folic acid, 0.006%-0.014% vitamin B12, 0.375%-0.853% sodium L-ascorbate, and 0.310%-0.643% edible carrier maltodextrin;

[0034] The compound vitamin consists of 2.41%-5.87% tricalcium phosphate, 0.10%-0.32% ferric pyrophosphate, 1.80%-6.11% magnesium carbonate, 4.20%-5.76% potassium citrate, 0.09%-0.21% dipotassium hydrogen phosphate, 3.78%-12.31% sodium citrate, 0.05%-0.13% zinc citrate, 0.02%-0.04% sodium selenite and 0.80%-2.19% edible carrier maltodextrin.

[0035] Furthermore, the nutritional composition can reduce the levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in serum, ileum and medulla oblongata, and can reduce the level of neurokinin substance P (SP) in serum and medulla oblongata.

[0036] A second aspect of the present invention provides a use of the nutritional composition described in the first aspect in the preparation of food, health products or medicines for improving nausea and vomiting during pregnancy and ensuring fetal growth and development.

[0037] Furthermore, the food, health product or medicine is in the form of powder, tablet, capsule or paste, including but not limited to the dosage forms listed above.

[0038] Beneficial effects of the present invention:

[0039] The present invention provides a nutritional composition, which, through the scientific proportion of multiple nutrients, can significantly reduce the frequency of nausea and vomiting during pregnancy under the synergistic effect of various nutrients, and can also comprehensively supplement the nutrients required during pregnancy, make up for the nutritional gap in pregnant women caused by vomiting, and meet the nutritional needs of pregnant women during pregnancy while ensuring the normal growth and development of the fetus. It has established a new intervention model of "symptom control-nutritional supplementation-fetal development", which can effectively improve the health level of mothers and babies, and is particularly suitable for pregnant women with symptoms of hyperemesis gravidarum. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 This is a test chart of kaolin intake in pregnant rats fed with different nutritional compositions on the 17th to 19th day of pregnancy;

[0041] Figure 2 The figure shows the test of 5-HT levels in serum, ileum and medulla oblongata of pregnant rats fed with different nutritional compositions;

[0042] Figure 3 The figure shows the test of 5-HIAA levels in serum, ileum and medulla oblongata of pregnant rats fed with different nutritional compositions;

[0043] Figure 4 The figure shows the SP levels in serum and medulla oblongata of pregnant rats fed with different nutritional compositions;

[0044] Figure 5 The figure shows the body weight of fetuses of pregnant rats fed with different nutritional compositions for 20 days. DETAILED DESCRIPTION

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present invention pertains. The terms used herein in the specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the relevant listed items. The term "includes" or "comprising" described in the present invention means that in addition to the components described, it may also include or contain other components. The term "includes" or "comprising" described in the present invention may also be replaced by the closed form "for" or "consisting of..."

[0046] The present invention will be further described below with reference to specific examples so that those skilled in the art can better understand the present invention and implement it, but the examples are not intended to limit the present invention.

[0047] Example 1

[0048] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0049] The mass of carbohydrates accounts for 14.35%, the mass of proteins accounts for 20.35%, the mass of fats accounts for 32.02%, the mass of dietary fiber accounts for 13.65%, the mass of complex vitamins accounts for 1.32%, the mass of complex minerals accounts for 16.21%, and the mass of blueberry powder accounts for 2.10%.

[0050] Among them, carbohydrates are composed of maltodextrin and solid corn syrup, with a mass proportion of 9.04% and 5.31% respectively.

[0051] The protein substance is composed of whey protein, soy protein, sodium caseinate and collagen peptide, with the mass proportions being 13.00%, 2.56%, 2.69% and 2.10% respectively.

[0052] The fat substances are composed of DHA algae oil, medium-chain triglycerides, sunflower oil, linseed oil, maltooligosaccharides, sodium caseinate, silicon dioxide, mono- and diglycerides of fatty acids, sodium tripolyphosphate and mixed tocopherol concentrate, with the mass proportions being 0.50%, 12.80%, 6.72%, 4.72%, 4.38%, 2.14%, 0.31%, 0.33%, 0.09% and 0.02% respectively.

[0053] Dietary fiber substances are composed of resistant dextrin and isomaltooligosaccharide, with a mass proportion of 10.75% and 2.91% respectively.

[0054] The compound vitamin is composed of vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12, sodium L-ascorbate and maltodextrin, with the mass proportions being 0.027%, 0.015%, 0.095%, 0.006%, 0.009%, 0.010%, 0.056%, 0.049%, 0.012%, 0.016%, 0.016%, 0.013%, 0.651% and 0.344% respectively.

[0055] The complex minerals are composed of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate, sodium selenite and maltodextrin, with the mass proportions being 3.38%, 0.30%, 2.71%, 4.40%, 0.19%, 4.27%, 0.12%, 0.03% and 0.81% respectively.

[0056] The above ingredients are mixed evenly to obtain a nutritional composition.

[0057] Example 2

[0058] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0059] The mass of carbohydrates accounts for 18.86%, the mass of proteins accounts for 24.69%, the mass of fats accounts for 27.16%, the mass of dietary fiber accounts for 12.71%, the mass of complex vitamins accounts for 1.20%, the mass of complex minerals accounts for 13.50%, and the mass of blueberry powder accounts for 1.88%.

[0060] Among them, carbohydrates are composed of maltodextrin and solid corn syrup, with a mass proportion of 12.13% and 6.73% respectively.

[0061] The protein substance is composed of whey protein, soy protein, sodium caseinate and collagen peptide, with the mass proportions being 17.37%, 3.14%, 2.18% and 2.00% respectively.

[0062] The fat substances are composed of DHA algae oil, medium-chain triglycerides, sunflower oil, linseed oil, maltooligosaccharides, sodium caseinate, silicon dioxide, mono- and diglycerides of fatty acids, sodium tripolyphosphate and mixed tocopherol concentrate, with the mass proportions being 0.32%, 10.44%, 6.76%, 3.67%, 3.63%, 1.68%, 0.29%, 0.27%, 0.07% and 0.02% respectively.

[0063] Dietary fiber substances are composed of resistant dextrin and isomaltooligosaccharide, with a mass proportion of 8.54% and 4.17% respectively.

[0064] The compound vitamin is composed of vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12, sodium L-ascorbate and maltodextrin, with the mass proportions being 0.031%, 0.014%, 0.102%, 0.005%, 0.009%, 0.008%, 0.048%, 0.035%, 0.010%, 0.013%, 0.013%, 0.010%, 0.502% and 0.400 respectively.

[0065] The complex minerals are composed of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate, sodium selenite and maltodextrin, with the mass proportions being 2.44%, 0.12%, 1.90%, 4.22%, 0.10%, 3.83%, 0.05%, 0.03% and 0.81% respectively.

[0066] The above ingredients are mixed evenly to obtain a nutritional composition.

[0067] Example 3

[0068] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0069] The mass of carbohydrates accounts for 21.97%, the mass of proteins accounts for 33.02%, the mass of fats accounts for 20.9%, the mass of dietary fiber accounts for 8.55%, the mass of complex vitamins accounts for 1.11%, the mass of complex minerals accounts for 13.25%, and the mass of blueberry powder accounts for 1.20%.

[0070] Among them, carbohydrates are composed of maltodextrin and solid corn syrup, with a mass proportion of 12.27% and 9.7% respectively.

[0071] The protein substances are composed of whey protein, soy protein, sodium caseinate and collagen peptide, with the mass proportions being 24.02%, 4.24%, 2.77% and 1.99% respectively.

[0072] The fat substances are composed of DHA algae oil, medium-chain triglycerides, sunflower oil, linseed oil, maltooligosaccharides, sodium caseinate, silicon dioxide, mono- and diglycerides of fatty acids, sodium tripolyphosphate and mixed tocopherol concentrate, with the mass proportions being 0.29%, 8.93%, 5.23%, 2.43%, 2.61%, 0.94%, 0.26%, 0.15%, 0.05% and 0.01% respectively.

[0073] Dietary fiber substances are composed of resistant dextrin and isomaltooligosaccharide, with a mass proportion of 6.81% and 1.74% respectively.

[0074] The compound vitamin is composed of vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12, sodium L-ascorbate and maltodextrin, with the mass proportions being 0.012%, 0.007%, 0.078%, 0.002%, 0.007%, 0.004%, 0.029%, 0.022%, 0.008%, 0.008%, 0.008%, 0.006%, 0.375% and 0.544% respectively.

[0075] The complex minerals are composed of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate, sodium selenite and maltodextrin, with the mass proportions being 2.41%, 0.10%, 1.80%, 4.20%, 0.09%, 3.78%, 0.05%, 0.02% and 0.80% respectively.

[0076] The above ingredients are mixed evenly to obtain a nutritional composition.

[0077] Example 4

[0078] This embodiment relates to a nutritional composition, specifically comprising the following ingredients:

[0079] The mass of carbohydrates accounts for 10.68%, the mass of proteins accounts for 17.94%, the mass of fats accounts for 20.9%, the mass of dietary fiber accounts for 18.37%, the mass of complex vitamins accounts for 1.35%, the mass of complex minerals accounts for 28.39%, and the mass of blueberry powder accounts for 2.37%.

[0080] Among them, carbohydrates are composed of maltodextrin and solid corn syrup, with a mass proportion of 7.06% and 3.62% respectively.

[0081] The protein substance is composed of whey protein, soy protein, sodium caseinate and collagen peptide, with the mass proportions being 11.93%, 2.03%, 1.99% and 1.99% respectively.

[0082] The fat substances are composed of DHA algae oil, medium-chain triglycerides, sunflower oil, linseed oil, maltooligosaccharides, sodium caseinate, silicon dioxide, mono- and diglycerides of fatty acids, sodium tripolyphosphate and mixed tocopherol concentrate, with the mass proportions being 0.29%, 8.93%, 5.23%, 2.43%, 2.61%, 0.94%, 0.26%, 0.15%, 0.05% and 0.01% respectively.

[0083] Dietary fiber substances are composed of resistant dextrin and isomaltooligosaccharide, with a mass proportion of 13.59% and 4.78% respectively.

[0084] The compound vitamin is composed of vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12, sodium L-ascorbate and maltodextrin, with the mass proportions being 0.046%, 0.019%, 0.132%, 0.008%, 0.011%, 0.012%, 0.064%, 0.051%, 0.013%, 0.018%, 0.020%, 0.014%, 0.632% and 0.31% respectively.

[0085] The complex minerals are composed of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate, sodium selenite and maltodextrin, with the mass proportions being 5.87%, 0.32%, 3.12%, 4.2%, 0.21%, 12.31%, 0.13%, 0.04% and 2.19% respectively.

[0086] The above ingredients are mixed evenly to obtain a nutritional composition.

[0087] Comparative Example 1

[0088] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: the addition amount of resistant dextrin is adjusted to 2.00%, the addition amount of maltodextrin is adjusted to 18.39%, medium-chain triglycerides and DHA algae oil are not added, and the corresponding parts are supplemented by sunflower oil; the mass proportions of the remaining ingredients remain unchanged, and the corresponding nutritional composition is prepared.

[0089] Comparative Example 2

[0090] This comparative example relates to a nutritional composition, which differs from Example 1 only in that the addition amount of resistant dextrin is adjusted to 4.00%, the addition amounts of medium-chain triglycerides, sunflower oil, and linseed oil are adjusted to 7.68%, 2.02%, and 3.31%, respectively; oligomaltodextrose, blueberry powder, vitamin B6, and sodium selenite are not added, and the corresponding parts are supplemented by solid corn syrup; the mass proportions of the remaining ingredients remain unchanged, and the corresponding nutritional composition is prepared.

[0091] Comparative Example 3

[0092] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: the addition amount of resistant dextrin is adjusted to 5.00%, the addition amounts of medium-chain triglycerides, sunflower oil, and linseed oil are adjusted to 6.50%, 5.00%, and 2.30%, respectively; the addition amounts of vitamin C and vitamin E are adjusted to 0.3% and 0.05%, respectively; low DHA algae oil and blueberry powder are not added, and the corresponding parts are supplemented by whey protein; the mass proportions of the remaining ingredients remain unchanged, and the corresponding nutritional composition is prepared.

[0093] Comparative Example 4

[0094] This comparative example relates to a nutritional composition, which differs from Example 1 only in that: oligomaltose is replaced by an equal amount of oligofructose, soy protein is replaced by an equal amount of whey protein, DHA algae oil is replaced by an equal amount of medium-chain triglycerides, and solid corn syrup is replaced by an equal amount of maltodextrin; the mass proportions of the remaining ingredients remain unchanged, and the corresponding nutritional composition is prepared.

[0095] Application and biochemical index testing

[0096] The nutritional compositions prepared in the above examples and comparative examples were fed to pregnant rats to establish a pica nausea and vomiting model. Kaolin intake, 5-HT, 5-HIAA, and SP levels in the pregnant rats treated with different nutritional compositions were measured, as well as fetal weights. This was done to evaluate the effects of the different nutritional compositions on nausea and vomiting in rats, as well as their nutritional intake and fetal growth and development. The details are as follows:

[0097] (1) Construction of a pica nausea and vomiting model

[0098] One hundred 8-week-old SPF female Sprague-Dawley rats and 50 8-week-old SPF male Sprague-Dawley rats were selected. The animals were housed in a well-ventilated environment with a constant temperature and humidity (22-25°C, 65%-70% humidity) and a 12-h light-12-h dark cycle. Water and food were available ad libitum.

[0099] After one week of adaptive feeding, the female rats were randomly divided into 10 groups, including a blank control group, a model group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, and Comparative Example 4 group, with 8 rats in each group. Female rats were co-housed with male rats at a ratio of 2:1 per cage. The presence of sperm on vaginal smear was recorded as day 0 of pregnancy.

[0100] Intervention began on day 1 of pregnancy. Groups 1, 2, 3, 4, 1, 2, 3, and 4 were gavaged with 3 g / kg·BW of the nutrient composition aqueous solution of Example 1, Example 2, Example 3, Example 4, 1, 2, 3, and 4, respectively. The blank control group and the model group were gavaged with an equal amount of normal saline. During this period, they ate and drank normally, and gavage continued until day 19 of pregnancy. One hour after gavage on day 16 of pregnancy, the model group, 1, 2, 3, 4, 1, 2, 3, and 4 were injected with 6 mg / kg·BW of cisplatin to establish a pica nausea and vomiting model. The blank control group was given an intraperitoneal injection of 0.9% sodium chloride solution.

[0101] Kaolin was introduced into the rats from the 10th day of gestation for adaptation, and the daily kaolin intake was recorded from the 17th to the 19th day of gestation after model establishment.

[0102] On gestational day 20, blood was collected from the abdominal aorta after anesthesia, and serum was separated and stored. Following blood collection, the rats were dissected, the fetuses removed and weighed, and the medulla oblongata and ileum were obtained, snap-frozen in liquid nitrogen, and immediately stored in a -80°C ultra-low temperature freezer for subsequent experiments.

[0103] (2) Kaolin intake test

[0104] Pregnant rats fed the different nutritional compositions were tested for kaolin intake on gestational days 17-19 to assess their pica, which indirectly reflects nausea and vomiting. Higher kaolin intake indicated more severe nausea and vomiting, thereby assessing the effects of the nutritional compositions on nausea and vomiting in rats.

[0105] The test results are as follows Figure 1As shown, the kaolin intake of pregnant rats in the model group was significantly higher than that in the blank control group (P<0.05), indicating that the model was successfully established. The kaolin intake of rats in Example 1 to 4 groups on the 17th to 19th day of pregnancy was close to that of the blank control group, and significantly lower than that of the model group, indicating that the intervention can effectively inhibit pica in rats and reduce nausea and vomiting behavior. The kaolin intake of rats in the comparative example 1 to 4 groups on the 17th to 19th day of pregnancy was close to that of the model group, with no significant difference (P>0.05), indicating that the nutritional compositions prepared in comparative examples 1 to 4 had no obvious alleviating effect on pica in rats.

[0106] (3) 5-HT and 5-HIAA level testing

[0107] 5-HT and 5-HIAA are important neurotransmitters and their metabolites. Cisplatin induces the synthesis and release of 5-HT, activating the 5-HT3A receptor and leading to pica in rats. Cisplatin treatment increases 5-HT levels in the rat serum, ileum, and medulla oblongata to varying degrees. 5-HIAA is the primary metabolite of 5-HT, and its level changes reflect the metabolic state of 5-HT, with 5-HIAA levels positively correlated with 5-HT levels. 5-HT and 5-HIAA levels can represent the level of pica in rats with a pica model. ELISA kits were used to measure 5-HT and 5-HIAA levels in rat serum, ileum, and medulla oblongata to assess the effects of various interventions on pica behavior in rats, thereby reflecting the inhibitory effect of the interventions on nausea and vomiting.

[0108] The results of 5-HT level test in rats are as follows Figure 2 As shown, the 5-HT levels in the serum, ileum and medulla of the model group rats were significantly higher than those in the blank control group (P<0.05), which further illustrates that the modeling was successful. In the serum, ileum and medulla of rats, the 5-HT levels of the Example 1 to 4 groups were significantly lower than those of the model group (P<0.05), and were close to those of the blank control group. The 5-HT levels of the comparative example 1 to 4 groups were higher than those of the Example 1 to 4 groups, and were not significantly different from those of the model group (P>0.05). The results show that the nutritional compositions prepared in Examples 1 to 4 can significantly reduce the 5-HT levels in rats, thereby inhibiting pica behavior, that is, alleviating nausea and vomiting behavior.

[0109] The results of 5-HIAA level test in rats are as follows Figure 3As shown, the 5-HIAA levels in serum, ileum and medulla oblongata of the model group rats were significantly higher than those in the blank control group (P<0.05), indicating that the modeling was successful. In rat serum, the 5-HIAA levels of Examples 1, 3, and 4 groups were significantly lower than those of the model group (P<0.05), and the levels of the other intervention groups were slightly lower than those of the model group, but the differences were not significant (P>0.05). In the ileum and medulla oblongata, the 5-HIAA levels of Examples 1 to 4 groups were significantly lower than those of the model group (P<0.05), while there were no significant differences between the Comparative Examples 1 to 4 groups and the model group (P>0.05). The results show that the nutritional compositions prepared by Examples 1 to 4 can significantly reduce the 5-HIAA levels in rats, while the nutritional compositions prepared by Comparative Examples 1 to 4 have no significant effect on the 5-HIAA levels in rats.

[0110] (4) SP content test

[0111] SP is a bioactive neurokinin produced by gastrointestinal endocrine cells and neurons and widely distributed throughout the gastrointestinal tract and central nervous system. SP is an endogenous ligand that induces emesis. Cisplatin treatment in rats increases SP secretion, which in turn transmits emetic signals and induces vomiting. ELISA kits were used to measure SP levels in rat serum and medulla oblongata to evaluate the effects of various interventions on nausea and vomiting in rats.

[0112] The results of SP level detection in rat serum and medulla oblongata are as follows Figure 4 As shown, the SP levels in the serum and medulla oblongata of the model group rats were significantly increased, significantly higher than the blank control group, indicating that the modeling was successful. The SP levels of the Example 1 to 4 groups were significantly reduced, significantly lower than the model group (P < 0.05), and close to the blank control group, indicating that the intervention substances in the Example 1 to 4 groups can significantly reduce the SP level in the rats, thereby reducing nausea and vomiting. In the medulla oblongata, the SP level of the comparative example 3 group was significantly lower than that of the model group, and had a certain effect, but the SP level was still higher than that of the example group. The results show that the nutritional composition prepared by Examples 1 to 4 can significantly reduce the SP level of rats and control nausea and vomiting behavior.

[0113] (5) Fetal weight test

[0114] Fetal weight reflects maternal health and fetal development during pregnancy. Malnutrition and frequent nausea and vomiting during pregnancy can lead to low fetal weight and developmental impairment. Fetal weight was measured to assess the effects of various nutritional compositions on fetal development.

[0115] Fetal weight measurements Figure 5As shown in the figure, the fetal weight of the model group was significantly lower than that of the blank control group (P<0.05), indicating that the fetal weight of the model group may be dysplastic. The fetal weight of the Example 1 to 4 groups intervened by the nutritional composition prepared by Examples 1-4, respectively, was normal, close to that of the blank control group, slightly lower than the blank control group, but significantly higher than the model group (P<0.05). Although the fetal weight of the comparative example 1 to 4 groups was higher than that of the model group, there was no significant difference (P>0.05). The above results show that the nutritional composition prepared by Examples 1 to 4 groups can ensure the nutritional intake of rats during pregnancy and promote the healthy development of fetal mice.

[0116] In summary, the nutritional compositions prepared in Examples 1-4 can reduce pica behavior by lowering the levels of 5-HT, 5-HIAA and SP in mice, that is, they have a significant inhibitory effect on nausea and vomiting behavior, and can maintain nutritional intake during pregnancy to promote the normal growth and development of fetal mice.

[0117] The above-described embodiments are merely preferred examples for the purpose of fully illustrating the present invention, and the scope of protection of the present invention is not limited thereto. Equivalent substitutions or modifications made by those skilled in the art based on the present invention are within the scope of protection of the present invention. The scope of protection of the present invention shall be subject to the claims.

Claims

1. A nutritional composition for improving nausea and vomiting during pregnancy and ensuring fetal growth and development, characterized in that: Contains the following ingredients by mass percentage: carbohydrates 10.68%-24.05%, proteins 17.93%-36.41%, fats 20.9%-52.94%, dietary fiber 8.55%-18.37%, complex vitamins 1.11%-1.35%, complex minerals 11.17%-37.27%, blueberry powder 1.20%-2.38%; The carbohydrates include maltodextrin, corn syrup solids; The protein substances include whey protein, soy protein, sodium caseinate, and collagen peptide; The fatty substances include DHA algae oil, medium chain triglycerides, sunflower oil and linseed oil; The dietary fiber substances include resistant dextrin and isomaltooligosaccharide.

2. The nutritional composition according to claim 1, characterized in that Contain at least one of the following characteristics: (1) The mass percentages of maltodextrin and solid corn syrup in the carbohydrate in the nutritional composition are 7.06%-14.35% and 3.62%-9.70%, respectively; (2) the mass percentages of whey protein, soy protein, sodium caseinate, and collagen peptide in the protein substances in the nutritional composition are 11.93%-24.02%, 2.03%-4.24%, 1.99%-4.70%, and 1.99%-3.45%, respectively; (3) The mass percentages of DHA algae oil, medium-chain triglycerides, sunflower oil, and flaxseed oil in the nutritional composition are 0.29%-0.65%, 7.41%-12.90%, 5.23%-7.13%, and 2.43%-4.89% respectively; (4) The mass percentages of resistant dextrin and oligosaccharide in the dietary fiber substances in the nutritional composition are 6.81%-13.59% and 1.74%-4.78%, respectively.

3. The nutritional composition according to claim 1, characterized in that The fat substance further comprises an edible carrier; the edible carrier comprises one or more of maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate, and mixed tocopherol concentrate.

4. The nutritional composition according to claim 3, characterized in that The edible carrier comprises maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate and mixed tocopherol concentrate; The mass percentages of maltooligosaccharide, sodium caseinate, silicon dioxide, mono- and diglycerol fatty acid esters, sodium tripolyphosphate, and mixed tocopherol concentrate in the fat substances in the nutritional composition are 2.61%-4.54%, 0.94%-2.71%, 0.26%-0.40%, 0.15%-0.40%, 0.05%-0.11%, and 0.01%-0.03%, respectively.

5. The nutritional composition according to claim 1, characterized in that The compound vitamins include vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12 and sodium L-ascorbate; The mass percentages of vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamine hydrochloride, vitamin B2, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, biotin, folic acid, vitamin B12 and sodium L-ascorbate in the vitamin complex in the nutritional composition are 0.012%-0.046%, 0.007%-0.019%, 0.078%-0.13% respectively. 2%, 0.002%-0.008%, 0.007%-0.011%, 0.004%-0.012%, 0.029%-0.064%, 0.022%-0.051%, 0.008%-0.013%, 0.008%-0.018%, 0.008%-0.020%, 0.006%-0.014%, 0.375%-0.853%.

6. The nutritional composition according to claim 5, characterized in that The compound vitamin further comprises maltodextrin as an edible carrier; the mass percentage of the maltodextrin as an edible carrier in the compound vitamin in the nutritional composition is 0.310%-0.643%.

7. The nutritional composition according to claim 1, characterized in that The compound minerals include tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate and sodium selenite; The mass percentages of tricalcium phosphate, ferric pyrophosphate, magnesium carbonate, potassium citrate, dipotassium hydrogen phosphate, sodium citrate, zinc citrate and sodium selenite in the composite minerals in the nutritional composition are 2.41%-5.87%, 0.10%-0.32%, 1.80%-6.11%, 4.20%-5.76%, 0.09%-0.21%, 3.78%-12.31%, 0.05%-0.13% and 0.02%-0.04%, respectively.

8. The nutritional composition according to claim 7, characterized in that The complex mineral further comprises maltodextrin as an edible carrier; the mass percentage of the edible carrier maltodextrin in the complex mineral in the nutritional composition is 0.80%-2.19%.

9. The nutritional composition according to claim 1, characterized in that According to the mass percentage of each component in the nutritional composition, The carbohydrates are composed of 7.06%-14.35% maltodextrin and 3.62%-9.70% solid corn syrup; The protein material consists of 11.93%-24.02% whey protein, 2.03%-4.24% soy protein, 1.99%-4.70% sodium caseinate and 1.99%-3.45% collagen peptide; The fatty substance consists of 0.29%-0.65% DHA algae oil, 7.41%-12.90% medium-chain triglycerides, 5.23%-7.13% sunflower oil, 2.43%-4.89% linseed oil, 2.61%-4.54% maltooligosaccharides, 0.94%-2.71% sodium caseinate, 0.26%-0.40% silicon dioxide, 0.15%-0.40% mono- and diglycerides of fatty acids, 0.05%-0.11% sodium tripolyphosphate and 0.01%-0.03% mixed tocopherol concentrate; The dietary fiber substance is composed of 6.81%-13.59% of resistant dextrin and 1.74%-4.78% of isomaltooligosaccharide; The compound vitamin comprises 0.012%-0.046% of vitamin A palmitate, 0.007%-0.019% of vitamin D3, 0.078%-0.132% of vitamin E acetate, 0.002%-0.008% of vitamin K1, 0.007%-0.011% of thiamine hydrochloride, 0.004%-0.012% of vitamin B2, 0.029%-0.064% of Nicotinamide, 0.022%-0.051% D-calcium pantothenate, 0.008%-0.013% pyridoxine hydrochloride, 0.008%-0.018% biotin, 0.008%-0.020% folic acid, 0.006%-0.014% vitamin B12, 0.375%-0.853% sodium L-ascorbate, and 0.310%-0.643% edible carrier maltodextrin; The complex minerals consist of 2.41%-5.87% of tricalcium phosphate, 0.10%-0.32% of ferric pyrophosphate, 1.80%-6.11% of magnesium carbonate, 4.20%-5.76% of potassium citrate, 0.09%-0.21% of dipotassium hydrogen phosphate, 3.78%-12.31% of sodium citrate, 0.05%-0.13% of zinc citrate, 0.02%-0.04% of sodium selenite and 0.80%-2.19% of edible carrier maltodextrin.

10. Use of the nutritional composition according to any one of claims 1 to 9 in the preparation of food, health products or medicines for improving nausea and vomiting during pregnancy and ensuring fetal growth and development.

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