All-cotton wet tissue

Abstract

The invention relates to the technical field of wet tissues, in particular to an all-cotton wet tissue which comprises a base material and a wet tissue immersion liquid, wherein the wet tissue immersion liquid contains 0.1-0.4 wt% of a thickening agent, 0.1-2 wt% of a surfactant, 0.14-0.28 wt% of a pH regulator, 0.01-0.35 wt% of an environment-friendly non-irritant bactericide, 0.1-1.5 wt% of propylene glycol, 0.01-0.2 wt% of essence and the balance of deionized water; the preparation process of the environment-friendly non-irritating bactericide comprises the following steps: dissolving propyl gallate in ethanol, adding into a tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, adding a chitosan sulfate catalyst, adjusting the pH value to 5-7, and stirring and reacting in a constant-temperature water bath at 60-80 DEG C for 4-8 hours to obtain the environment-friendly non-irritating bactericide. According to the all-cotton wet tissue, the environment-friendly non-irritating bactericide is added into the wet tissue immersion liquid, so that the all-cotton wet tissue has very good environment-friendly non-irritating bactericidal performance.

Description

Technical Field

[0001] This invention relates to the field of wet wipes technology, specifically to a pure cotton wet wipe. Background Technology

[0002] Wet wipes are moist tissues used to wipe the skin, and they have cleaning, disinfecting, antibacterial and moisturizing functions.

[0003] Chinese Patent CN 109820772 B discloses an antibacterial skin care wipe and its preparation method. The antibacterial skin care wipe includes a wipe base material and a wipe impurity. The wipe impurity comprises the following components in parts by weight: 0.2-1 parts of camphor leaf essential oil from *Cinnamomum camphora*, 0.2-1 parts of borneol extract, and 60-70 parts of camphor leaf hydrosol from *Cinnamomum camphora*. The above-mentioned antibacterial skin care wipe contains a reasonable ratio of natural plant extracts, making it gentle and non-irritating to the skin.

[0004] In the existing technology, all-cotton wipes have poor antibacterial effect, and in particular, the antibacterial effect needs to be improved. Summary of the Invention

[0005] The purpose of this invention is to provide a cotton wet wipe. The technical problem solved by this invention is that cotton wet wipes have poor antibacterial effect, and in particular, the antibacterial effect needs to be improved.

[0006] The purpose of the present invention can be achieved through the following technical solutions: A cotton wet wipe, comprising a substrate and a wet wipe impregnation solution: The wet wipe soaking solution contains 0.1-0.4 wt% thickener, 0.1-2 wt% surfactant, 0.14-0.28 wt% pH adjuster, 0.01-0.35 wt% environmentally friendly and non-irritating bactericide, 0.1-1.5 wt% propylene glycol, 0.01-0.2 wt% fragrance, and the balance being deionized water; The preparation process of the environmentally friendly and non-irritating bactericide includes the following steps: Propyl gallate was dissolved in ethanol and added to a solution of tea polyphenol-PEG acrylate-modified quaternary ammonium salt modified carboxymethyl chitosan. Chitosan sulfate catalyst was added, and the pH was adjusted to 5-7. The mixture was stirred in a constant temperature water bath at 60-80℃ for 4-8 hours to obtain an environmentally friendly and non-irritating bactericide.

[0007] As a further embodiment of the present invention, the mass ratio of propyl gallate, ethanol, tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, and chitosan sulfate is 400-500:100:2000:1-2.

[0008] As a further aspect of the present invention: the preparation process of the tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution includes: Tea polyphenol-PEG acrylate was slowly added dropwise to an activated quaternary ammonium salt modified carboxymethyl chitosan solution, and the reaction was carried out at 25°C in the dark for 24 hours. Then, 0.1 M glycine was added to quench the unreacted active ester, and the mixture was stirred for another hour to obtain tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan.

[0009] As a further aspect of the present invention: the preparation process of the activated quaternary ammonium salt modified carboxymethyl chitosan solution includes the following steps: Dissolve quaternary ammonium salt modified carboxymethyl chitosan in 100 mL of LME S buffer and stir until completely dissolved; then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide, and activate by stirring at 25°C in the dark for 30 minutes to obtain an activated quaternary ammonium salt modified carboxymethyl chitosan solution.

[0010] As a further embodiment of the present invention: the mass ratio of quaternary ammonium salt modified carboxymethyl chitosan, MES buffer, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, tea polyphenol-PEG acrylate, and glycine is 1000:300-400:180-200:500:100.

[0011] As a further aspect of the present invention: the preparation process of quaternary ammonium salt modified N-carboxymethyl chitosan includes the following steps: Carboxymethyl chitosan and 5-50% glycidyltrimethylammonium chloride were dissolved in isopropanol at a mass ratio of 1:1 and reacted for 16 hours. The product was filtered, washed with acetone and methanol, and then freeze-dried to obtain quaternary ammonium salt modified N-carboxymethyl chitosan.

[0012] As a further aspect of the present invention: the thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL, with a mass ratio of 1-10:1-3.5.

[0013] As a further aspect of the present invention, the mass ratio of the nonwoven fabric substrate to the wet wipe soaking liquid is 10-20:5-7.

[0014] As a further aspect of the present invention, it includes the following steps: The prepared nonwoven fabric substrate is placed in a wet wipe soaking solution and soaked at room temperature in the dark for 12 to 36 hours.

[0015] As a further aspect of the present invention, the preparation process of the nonwoven fabric substrate includes the following steps: Bamboo pulp fibers with a length of 35mm to 50mm and a diameter of 0.05mm to 0.1mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 3mm to 5mm is obtained.

[0016] The beneficial effects of this invention are: Carboxymethyl chitosan (CMCS) is a derivative of chitosan modified by carboxymethylation. It has good water solubility, biocompatibility and antibacterial properties. CMCS destroys bacterial cell membranes through positive charge adsorption and inhibits common pathogenic bacteria such as Escherichia coli and Staphylococcus aureus.

[0017] The chemical structure of the tea polyphenol-PEG acrylate is as follows: the catechin structure of tea polyphenol (EGCG) has an antioxidant capacity 10 times that of vitamin C; the polyethylene glycol (PEG) segment enhances water solubility and reduces dependence on organic solvents; tea polyphenol is a natural extract; PEG modification reduces the astringency of tea polyphenol; therefore, the tea polyphenol-PEG acrylate of this invention has excellent antioxidant, environmentally friendly and non-irritating properties; the structure of TP-PEG-A contains antioxidant groups of tea polyphenol, polyethylene glycol segments and acrylate groups; while CMCS contains carboxymethyl groups, and may react with TP-PEG-A through carboxyl groups to prepare tea polyphenol-PEG acrylate modified carboxymethyl chitosan; tea polyphenol-PEG acrylate modified carboxymethyl chitosan delays the oxidative degradation of carboxymethyl chitosan, which can effectively solve the problem that carboxymethyl chitosan is prone to degradation under light, high temperature or oxidative conditions, leading to molecular chain breakage and gradual loss of antibacterial properties; Propyl gallate can delay the oxidation of tea polyphenol-PEG acrylate, effectively solving the problem that the phenolic hydroxyl groups of tea polyphenols are easily oxidized to quinone compounds by oxygen, light or metal ions (such as Fe³⁺), resulting in a significant decrease in antioxidant activity. Introducing propyl gallate into the quaternary ammonium group molecular chain and using its free radical scavenging ability to inhibit the oxidation chain reaction can effectively improve the antioxidant properties of carboxymethyl chitosan. By quaternizing N-carboxymethyl chitosan, quaternary ammonium salt-modified N-carboxymethyl chitosan is obtained. By grafting quaternary ammonium groups onto N-carboxymethyl chitosan, the antibacterial activity is enhanced. This can effectively solve the problem that the introduction of hydrophilic groups (-CH2COOH) by carboxymethylation weakens the original positive charge density of chitosan, reduces its electrostatic adsorption capacity with negatively charged bacterial cell membranes, and thus leads to a significant decrease in antibacterial activity compared to unmodified chitosan. Therefore, this invention adds an environmentally friendly and non-irritating bactericide to the wet wipe soaking solution, giving the all-cotton wet wipes excellent environmentally friendly and non-irritating bactericidal properties. Detailed Implementation

[0018] To enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention. Example 1

[0019] Embodiment 1 of the present invention provides a cotton wet wipe, comprising a substrate and a wet wipe impregnation solution: The wet wipe soaking solution contains 0.1 wt% thickener, 0.1 wt% surfactant, 0.14 wt% pH adjuster, 0.01 wt% environmentally friendly and non-irritating bactericide, 0.1 wt% propylene glycol, 0.01 wt% fragrance, and the balance being deionized water; The thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL in a mass ratio of 1:1. The preparation process of the environmentally friendly and non-irritating bactericide includes the following steps: Step 1: Dissolve carboxymethyl chitosan and 5% glycidyltrimethylammonium chloride in isopropanol at a mass ratio of 1:1 and react for 16 hours. Filter the product, wash with acetone and methanol, and freeze dry to obtain quaternary ammonium salt modified N-carboxymethyl chitosan. Step 2: Dissolve quaternary ammonium salt modified carboxymethyl chitosan in 100 mL of LME S buffer and stir until completely dissolved; then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide, stir and activate at 25°C in the dark for 30 minutes to obtain an activated quaternary ammonium salt modified carboxymethyl chitosan solution. Tea polyphenol-PEG acrylate was slowly added dropwise to an activated quaternary ammonium salt modified carboxymethyl chitosan solution, and the reaction was carried out at 25°C in the dark for 24 hours. Then, 0.1 M glycine was added to quench the unreacted active ester, and the mixture was stirred for another hour to obtain tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan. The mass ratio of quaternary ammonium salt modified carboxymethyl chitosan, MES buffer, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, tea polyphenol-PEG acrylate, and glycine is 1000:300:180:500:100. Step 3: Dissolve propyl gallate in ethanol and add it to a solution of tea polyphenol-PEG acrylate-modified quaternary ammonium salt-modified carboxymethyl chitosan. Add chitosan sulfate catalyst, adjust the pH to 5-7, and stir the reaction in a constant temperature water bath at 60-80℃ for 4-8 hours to obtain an environmentally friendly and non-irritating bactericide. The mass ratio of propyl gallate, ethanol, tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, and chitosan sulfate is 400:100:2000:1.

[0020] Embodiment 1 of the present invention also provides a preparation process for all-cotton wet wipes, including the following steps: Bamboo pulp fibers with a length of 35mm and a diameter of 0.05mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 3mm is obtained. The prepared nonwoven fabric substrate was placed in a wet wipe soaking solution and soaked at room temperature in the dark for 12 hours. The mass ratio of the nonwoven fabric substrate to the wet wipe soaking solution is 10:5. Example 2

[0021] Embodiment 2 of the present invention provides a cotton wet wipe, comprising a substrate and a wet wipe impregnation solution: The wet wipe soaking solution contains 0.3 wt% thickener, 1.0 wt% surfactant, 0.20 wt% pH adjuster, 0.20 wt% environmentally friendly and non-irritating bactericide, 0.8 wt% propylene glycol, 0.10 wt% fragrance, and the balance being deionized water; The thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL in a mass ratio of 5:2.5. The preparation process of the environmentally friendly and non-irritating bactericide includes the following steps: Step 1: Dissolve carboxymethyl chitosan and 20% glycidyltrimethylammonium chloride in isopropanol at a mass ratio of 1:1 and react for 16 hours. Filter the product, wash with acetone and methanol, and freeze dry to obtain quaternary ammonium salt modified N-carboxymethyl chitosan. Step 2: Dissolve quaternary ammonium salt modified carboxymethyl chitosan in 100 mL of LME S buffer and stir until completely dissolved; then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide, stir and activate at 25°C in the dark for 30 minutes to obtain an activated quaternary ammonium salt modified carboxymethyl chitosan solution. Tea polyphenol-PEG acrylate was slowly added dropwise to an activated quaternary ammonium salt modified carboxymethyl chitosan solution, and the reaction was carried out at 25°C in the dark for 24 hours. Then, 0.1 M glycine was added to quench the unreacted active ester, and the mixture was stirred for another hour to obtain tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan. The mass ratio of quaternary ammonium salt modified carboxymethyl chitosan, MES buffer, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, tea polyphenol-PEG acrylate, and glycine is 1000:350:190:500:100. Step 3: Dissolve propyl gallate in ethanol and add it to a solution of tea polyphenol-PEG acrylate-modified quaternary ammonium salt-modified carboxymethyl chitosan. Add chitosan sulfate catalyst, adjust the pH to 6, and stir the reaction in a 70℃ constant temperature water bath for 6 hours to obtain an environmentally friendly and non-irritating bactericide. The mass ratio of propyl gallate, ethanol, tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, and chitosan sulfate is 450:100:2000:1.

[0022] Embodiment 2 of the present invention also provides a preparation process for all-cotton wet wipes, including the following steps: Bamboo pulp fibers with a length of 40mm and a diameter of 0.07mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 4mm is obtained. The prepared nonwoven fabric substrate was placed in a wet wipe soaking solution and soaked at room temperature in the dark for 25 hours. The mass ratio of the nonwoven fabric substrate to the wet wipe soaking solution is 15:6. Example 3

[0023] Embodiment 3 of the present invention provides a cotton wet wipe, comprising a substrate and a wet wipe impregnation solution: The wet wipe soaking solution contains 0.4 wt% thickener, 2 wt% surfactant, 0.28 wt% pH adjuster, 0.35 wt% environmentally friendly and non-irritating bactericide, 1.5 wt% propylene glycol, 0.2 wt% fragrance, and the remainder deionized water; The thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL in a mass ratio of 10:3.5. The preparation process of the environmentally friendly and non-irritating bactericide includes the following steps: Step 1: Dissolve carboxymethyl chitosan and 50% glycidyltrimethylammonium chloride in isopropanol at a mass ratio of 1:1 and react for 16 hours. Filter the product, wash with acetone and methanol, and freeze dry to obtain quaternary ammonium salt modified N-carboxymethyl chitosan. Step 2: Dissolve quaternary ammonium salt modified carboxymethyl chitosan in 100 mL of LME S buffer and stir until completely dissolved; then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide, stir and activate at 25°C in the dark for 30 minutes to obtain an activated quaternary ammonium salt modified carboxymethyl chitosan solution. Tea polyphenol-PEG acrylate was slowly added dropwise to an activated quaternary ammonium salt modified carboxymethyl chitosan solution, and the reaction was carried out at 25°C in the dark for 24 hours. Then, 0.1 M glycine was added to quench the unreacted active ester, and the mixture was stirred for another hour to obtain tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan. The mass ratio of quaternary ammonium salt modified carboxymethyl chitosan, MES buffer, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, tea polyphenol-PEG acrylate, and glycine is 1000:400:200:500:100. Step 3: Dissolve propyl gallate in ethanol and add it to a solution of tea polyphenol-PEG acrylate-modified quaternary ammonium salt-modified carboxymethyl chitosan. Add chitosan sulfate catalyst, adjust the pH to 7, and stir the reaction in an 80℃ constant temperature water bath for 8 hours to obtain an environmentally friendly and non-irritating bactericide. The mass ratio of propyl gallate, ethanol, tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, and chitosan sulfate is 500:100:2000:2.

[0024] Embodiment 3 of the present invention also provides a preparation process for all-cotton wet wipes, including the following steps: Bamboo pulp fibers with a length of 50mm and a diameter of 0.1mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 5mm is obtained. The prepared nonwoven fabric substrate was placed in a wet wipe soaking solution and soaked at room temperature in the dark for 36 hours. The mass ratio of the nonwoven fabric substrate to the wet wipe soaking solution is 20:7.

[0025] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not contain any environmentally friendly, non-irritating bactericides in the wet wipe soaking solution; Comparative Example 1 provides an all-cotton wet wipe, including a substrate and a wet wipe soaking solution: The wet wipe soaking solution contains 0.1 wt% thickener, 0.1 wt% surfactant, 0.14 wt% pH adjuster, 0.1 wt% propylene glycol, 0.01 wt% fragrance, and the balance being deionized water; The thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL in a mass ratio of 1:1. Comparative Example 1 of this invention also provides a process for preparing all-cotton wet wipes, comprising the following steps: Bamboo pulp fibers with a length of 35mm to 50mm and a diameter of 0.05mm to 0.1mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 3mm to 5mm is obtained. The prepared nonwoven fabric substrate was placed in a wet wipe soaking solution and soaked at room temperature in the dark for 12 to 36 hours. The mass ratio of the nonwoven fabric substrate to the wet wipe soaking solution is 10:5.

[0026] Performance testing: The antibacterial properties of the cotton wipes from Examples 1-3 and Comparative Example 1 were tested, and the results are shown in the table below:

[0027] As shown in the table above, the all-cotton wipes prepared by the present invention using environmentally friendly and non-irritating bactericides exhibit excellent antibacterial effects and long-lasting antibacterial properties. The above provides a detailed description of one embodiment of the present invention, but this description is merely a preferred embodiment and should not be considered as limiting the scope of the invention. All equivalent variations and improvements made within the scope of the present invention should still fall within the patent coverage of the present invention.

Claims

1. A type of all-cotton wet wipe, characterized in that, Including the substrate and the wet wipe impregnation solution: The wet wipe soaking solution contains 0.1-0.4 wt% thickener, 0.1-2 wt% surfactant, 0.14-0.28 wt% pH adjuster, 0.01-0.35 wt% environmentally friendly and non-irritating bactericide, 0.1-1.5 wt% propylene glycol, 0.01-0.2 wt% fragrance, and the balance being deionized water; The preparation process of the environmentally friendly and non-irritating bactericide includes the following steps: Propyl gallate was dissolved in ethanol and added to a solution of tea polyphenol-PEG acrylate-modified quaternary ammonium salt modified carboxymethyl chitosan. Chitosan sulfate catalyst was added, and the pH was adjusted to 5-7. The mixture was stirred in a constant temperature water bath at 60-80℃ for 4-8 hours to obtain an environmentally friendly and non-irritating bactericide.

2. The all-cotton wet wipe according to claim 1, characterized in that, The mass ratio of propyl gallate, ethanol, tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution, and chitosan sulfate is 400-500:100:2000:1-2.

3. The all-cotton wet wipe according to claim 2, characterized in that, The preparation process of tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan solution includes: Tea polyphenol-PEG acrylate was slowly added dropwise to an activated quaternary ammonium salt modified carboxymethyl chitosan solution, and the reaction was carried out at 25°C in the dark for 24 hours. Then, 0.1 M glycine was added to quench the unreacted active ester, and the mixture was stirred for another hour to obtain tea polyphenol-PEG acrylate modified quaternary ammonium salt modified carboxymethyl chitosan.

4. The all-cotton wet wipe according to claim 3, characterized in that, The preparation process of activated quaternary ammonium salt modified carboxymethyl chitosan solution includes the following steps: Dissolve quaternary ammonium salt modified carboxymethyl chitosan in 100 mL of LME S buffer and stir until completely dissolved; then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide and hydroxysuccinimide, and activate by stirring at 25°C in the dark for 30 minutes to obtain an activated quaternary ammonium salt modified carboxymethyl chitosan solution.

5. A cotton wet wipe according to claim 4, characterized in that, The mass ratio of quaternary ammonium salt modified carboxymethyl chitosan, MES buffer, 1-ethyl-(3-dimethylaminopropyl)carbodiimide, N-hydroxysuccinimide, tea polyphenol-PEG acrylate, and glycine is 1000:300-400:180-200:500:

100.

6. The all-cotton wet wipe according to claim 5, characterized in that, The preparation process of quaternary ammonium salt modified N-carboxymethyl chitosan includes the following steps: Carboxymethyl chitosan and 5-50% glycidyltrimethylammonium chloride were dissolved in isopropanol at a mass ratio of 1:1 and reacted for 16 hours. The product was filtered, washed with acetone and methanol, and then freeze-dried to obtain quaternary ammonium salt modified N-carboxymethyl chitosan.

7. The all-cotton wet wipe according to claim 1, characterized in that, The thickener is a mixture of Carbopol Ultraz 20 and Cremophor EL in a mass ratio of 1-10:1-3.

5.

8. A cotton wet wipe according to claim 1, characterized in that, The mass ratio of nonwoven fabric substrate to wet wipe soaking solution is 10-20:5-7.

9. A cotton wet wipe according to claim 1, characterized in that, The manufacturing process of all-cotton wet wipes includes the following steps: The prepared nonwoven fabric substrate is placed in a wet wipe soaking solution and soaked at room temperature in the dark for 12 to 36 hours.

10. A cotton wet wipe according to claim 9, characterized in that, The preparation process of nonwoven fabric substrate includes the following steps: Bamboo pulp fibers with a length of 35mm to 50mm and a diameter of 0.05mm to 0.1mm are used as raw materials. After cross-laying and hydroentangling, bamboo pulp nonwoven fabric is produced. After cutting and high-temperature sterilization, a nonwoven fabric substrate with a thickness of 3mm to 5mm is obtained.

Images