Special meal for supplementing potassium as well as preparation method and application of special meal

Abstract

The invention discloses a potassium-supplementing special diet as well as a preparation method and application thereof. The potassium-supplementing special diet is mainly prepared from the following substances in parts by weight: 42 to 43.5 parts of trehalose, 24 to 26 parts of potassium, 13 to 17 parts of dietary fiber, 9 to 11 parts of konjaku flour, 1.6 to 3 parts of acidulant, 1.5 to 1.8 parts of inorganic salt, 0.3 to 0.4 part of L-ascorbic acid, 0.005 to 0.008 part of riboflavin, 0.005 to 0.015 part of thiamine nitrate, 1.8 to 2.0 parts of food essence and 0.19 to 0.25 part of sweetening agent. The potassium-supplementing special diet provided by the invention promotes gastrointestinal absorption, greatly increases the compliance of patients, is suitable for long-term potassium supplement, can reduce the irritation of potassium chloride to gastrointestinal tracts to the minimum, enables the potassium chloride to have small side effects, and can supplement sufficient potassium by adopting special diet official documents.

Description

Technical Field

[0001] This invention relates to the field of special dietary technology, and in particular to a potassium-supplementing special diet, its preparation method, and its application. Background Technology

[0002] Currently, many patients with chronic diseases require long-term potassium supplementation in clinical practice, mainly in the following situations: 1. Approximately 10 million patients with heart failure in my country, most of whom require long-term use of diuretics to improve heart failure symptoms, leading to hypokalemia due to potassium loss caused by long-term diuretic use; 2. Patients with ion channel diseases in the cardiovascular field, for whom maintaining normal serum potassium is crucial. The electrolyte potassium is the most important element for maintaining normal cardiac electrical activity, and potassium deficiency can easily lead to malignant arrhythmias or even sudden death; 3. Some patients with hypertension need to take antihypertensive drugs containing diuretics for a long time to control their blood pressure. According to the "Chinese Hypertension..." According to the "Prevention and Treatment Guidelines 2024 Revised Edition", the prevalence of hypertension among adults aged 18 and above in my country is approximately 27.9%, affecting about 245 million people. About 30% of these individuals receive regular medication to control their blood pressure (awareness rate 51.6%, treatment rate 45.8%, control rate 6.8%). Of these, about 10-15% use diuretics to lower blood pressure. Therefore, approximately 9-10 million hypertensive patients require long-term diuretic use and potassium supplementation as an alternative treatment. All three groups mentioned above are at risk of hypokalemia due to diuretic use and, given their underlying organic heart disease, are at high risk of sudden death, thus requiring long-term potassium supplementation.

[0003] In clinical practice, commonly used potassium supplements include intravenous potassium chloride, oral potassium chloride tablets, and oral potassium magnesium aspartate tablets. However, the following are some prominent issues with currently approved potassium supplements: 1. Intravenous potassium supplementation often causes pain at the infusion site due to venous irritation, and the long infusion time makes it difficult for most patients to tolerate. Furthermore, intravenous potassium supplementation is only suitable for hospitalized patients and not for long-term use. 2. Oral potassium supplementation commonly uses potassium chloride tablets and potassium chloride injections. Both tablets and liquids have poor taste, and the slow disintegration of tablets in the gastrointestinal tract causes strong irritation, making long-term use difficult for patients. Therefore, current clinical treatment of potassium supplementation presents the following problems: many patients are potassium deficient, and these patients are prone to serious complications with severe consequences. Existing intravenous and oral potassium supplements are difficult for patients to tolerate for long-term use due to local pain during infusion, low potassium dosage, gastrointestinal irritation, and poor taste.

[0004] In view of the above, it is necessary to improve the existing potassium supplementation methods to make them suitable for the current needs of patients. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention provides a special potassium-supplementing diet, composed of the following substances in parts by weight: trehalose 42-43.5 parts, potassium 24-26 parts, dietary fiber 13-17 parts, konjac flour 9-11 parts, acidulant 1.6-3 parts, inorganic salts 1.5-1.8 parts, L-ascorbic acid 0.3-0.4 parts, riboflavin 0.005-0.008 parts, thiamine nitrate 0.005-0.015 parts, food flavoring 1.8-2.0 parts, and sweetener 0.19-0.25 parts.

[0006] As a further supplement to this technical solution, the potassium is potassium chloride and / or potassium citrate and / or potassium magnesium aspartate.

[0007] As a further supplement to this technical solution, the potassium is potassium chloride or potassium citrate.

[0008] As a further supplement to this technical solution, the dietary fiber includes one or more of orange powder, fructooligosaccharides, glucan, or polydextrose.

[0009] As a further supplement to this technical solution, the dietary fiber is selected from orange powder and fructooligosaccharides, wherein the orange powder is 4-6 parts and / or the fructooligosaccharides are 9-11 parts.

[0010] As a further supplement to this technical solution, the acidulant includes one or more of citric acid, sodium citrate, lactic acid, phosphoric acid, tartaric acid, and malic acid.

[0011] As a further supplement to this technical solution, the acidulant is citric acid and / or sodium citrate.

[0012] As a further supplement to this technical solution, the acidulant is citric acid.

[0013] As a further supplement to this technical solution, the sweetener includes one or more of 4,1,6,-trichlorodeoxygalactosucrose, cyclohexylsulfamic acid, semathymidine, acesulfame potassium, o-benzoylsulfonamide, or hesperidin.

[0014] As a further supplement to this technical solution, the inorganic salt includes one or more of sodium chloride, magnesium chloride, sodium bicarbonate, or calcium salt.

[0015] As a further supplement to this technical solution, the sodium chloride is 0.8 parts and / or magnesium chloride is 0.8 parts.

[0016] As a further supplement to this technical solution, the food flavoring is L-arginine.

[0017] As a further supplement to this technical solution, the potassium-supplementing special diet consists of the following substances in parts by weight: trehalose 42-43.5 parts, potassium 24-26 parts, dietary fiber 13-17 parts, konjac powder 9-11 parts, citric acid 1.6-3 parts, inorganic salts 1.5-1.8 parts, L-ascorbic acid 0.3-0.4 parts, riboflavin 0.005-0.008 parts, thiamine nitrate 0.005-0.015 parts, L-arginine 1.8-2.0 parts, and sweetener 0.19-0.25 parts.

[0018] In another aspect, the present invention provides a method for preparing the above-mentioned potassium-supplementing special diet, which includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salt, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring and sweetener.

[0019] In another aspect, the present invention also provides the application of the above-mentioned potassium-supplemented special diet in the preparation of health foods and / or potassium supplements that help protect the gastric mucosa.

[0020] (III) Beneficial Effects

[0021] This invention provides a special potassium-supplementing diet, its preparation method, and its application. Compared with existing technologies, it has the following beneficial effects:

[0022] 1. Promotes gastrointestinal absorption, greatly increases patient compliance, and is suitable for long-term potassium supplementation. All ingredients are food-grade, which minimizes the irritation of potassium chloride to the gastrointestinal tract and reduces side effects. It also has a special dietary approval and can supplement sufficient potassium. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] As used in this article, “containing,” “having,” or “including” includes “containing,” “mainly composed of,” “substantially composed of,” and “composed of”; “mainly composed of,” “substantially composed of,” and “composed of” are subordinate concepts of “containing,” “having,” or “including.”

[0025] Unless otherwise specified, the experimental methods used in the following examples are conventional methods, and the reagents, methods and equipment used are conventional reagents, methods and equipment in this technical field.

[0026] Example 1:

[0027] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42.5 parts, potassium 25 parts, dietary fiber 15 parts, konjac flour 10 parts, acidulant 2.6 parts, inorganic salts 1.6 parts, L-ascorbic acid 0.3 parts, riboflavin 0.006 parts, thiamine nitrate 0.01 parts, food flavoring 1.8 parts, and sweetener 0.19 parts.

[0028] The dietary fiber consists of orange powder and fructooligosaccharides, with 5 parts orange powder and 10 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is 1.5 parts citric acid and 1.1 parts sodium citrate; the potassium is potassium chloride; the inorganic salts are 0.8 parts sodium chloride and 0.8 parts magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0029] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salts, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring, and sweetener to make 5g / bag.

[0030] The method of consuming the potassium-supplementing special dietary supplement includes the following steps: Take one packet each time, mix it with 150ml of warm water, or add it to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume it 2-3 times a day.

[0031] Comparative Example 1:

[0032] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42.5 parts, potassium 25 parts, dietary fiber 15 parts, konjac flour 10 parts, acidulant 2.6 parts, inorganic salts 1.6 parts, food flavoring 1.8 parts, and sweetener 0.19 parts.

[0033] The dietary fiber consists of orange powder and fructooligosaccharides, with 5 parts orange powder and 10 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is 1.5 parts citric acid and 1.1 parts sodium citrate; the potassium is potassium chloride; the inorganic salts are 0.8 parts sodium chloride and 0.8 parts magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0034] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac powder, acidulant, inorganic salt, food flavoring, and sweetener to make 5g / bag.

[0035] The method of consumption includes the following steps: Take 2 packets each time, mix with 150ml of warm water, or add to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0036] Comparative Example 2:

[0037] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42.5 parts, potassium 25 parts, dietary fiber 15 parts, konjac flour 10 parts, acidulant 2.6 parts, inorganic salts 1.6 parts, L-ascorbic acid 0.6 parts, food flavoring 1.8 parts, and sweetener 0.19 parts.

[0038] The dietary fiber consists of orange powder and fructooligosaccharides, with 5 parts orange powder and 10 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is 1.5 parts citric acid and 1.1 parts sodium citrate; the potassium is potassium chloride; the inorganic salts are 0.8 parts sodium chloride and 0.8 parts magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0039] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salt, L-ascorbic acid, food flavoring, and sweetener to make 5g / bag.

[0040] The method of consumption includes the following steps: Take 2 packets each time, mix with 150ml of warm water, or add to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0041] Comparative Example 3:

[0042] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42.5 parts, potassium 25 parts, dietary fiber 15 parts, konjac flour 10 parts, acidulant 2.6 parts, inorganic salts 1.6 parts, riboflavin 0.012 parts, food flavoring 1.8 parts, and sweetener 0.19 parts.

[0043] The dietary fiber consists of orange powder and fructooligosaccharides, with 5 parts orange powder and 10 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is 1.5 parts citric acid and 1.1 parts sodium citrate; the potassium is potassium chloride; the inorganic salts are 0.8 parts sodium chloride and 0.8 parts magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0044] A method for preparing a potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salts, riboflavin, food flavoring, and sweetener to form a 5g / bag.

[0045] The method of consumption includes the following steps: Take 2 packets each time, mix with 150ml of warm water, or add to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0046] Comparative Example 4:

[0047] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42.5 parts, potassium 25 parts, dietary fiber 15 parts, konjac flour 10 parts, acidulant 2.6 parts, inorganic salts 1.6 parts, thiamine nitrate 0.02 parts, food flavoring 1.8 parts, and sweetener 0.19 parts.

[0048] The dietary fiber consists of orange powder and fructooligosaccharides, with 5 parts orange powder and 10 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is 1.5 parts citric acid and 1.1 parts sodium citrate; the potassium is potassium chloride; the inorganic salts are 0.8 parts sodium chloride and 0.8 parts magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0049] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salt, thiamine nitrate, food flavoring, and sweetener to make 5g / bag.

[0050] The method of consumption includes the following steps: Take 2 packets each time, mix with 150ml of warm water, or add to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0051] Results Comparison: Using conventional potassium absorption testing methods (which are existing technologies and will not be elaborated here), the potassium supplementation effects of Comparative Examples 1-4 are not as good as those of Example 1, and the dosage of Comparative Examples 1-4 is twice that of Example 1. Therefore, the present invention has better application effects.

[0052] Example 2:

[0053] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 42 parts, potassium 26 parts, dietary fiber 14 parts, konjac flour 11 parts, acidulant 3 parts, inorganic salts 1.5 parts, L-ascorbic acid 0.4 parts, riboflavin 0.005 parts, thiamine nitrate 0.015 parts, food flavoring 2 parts, and sweetener 0.2 parts;

[0054] The dietary fiber consists of orange powder and dextran, with 5 parts orange powder and 9 parts dextran; the sweetener consists of 0.1 parts 4,1,6,-trichlorodeoxygalactosyl sucrose and 0.1 parts cyclohexylsulfamic acid; the acidulant consists of 2 parts citric acid and 1 part sodium citrate combined; the potassium is potassium chloride; the inorganic salt is magnesium chloride; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0055] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salts, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring, and sweetener to make 5g / bag.

[0056] The method of consumption includes the following steps: Take one packet each time, mix it with 150ml of warm water, or add it to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0057] Example 3:

[0058] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 43.5 parts, potassium 24 parts, dietary fiber 17 parts, konjac flour 9 parts, acidulant 1.6 parts, inorganic salts 1.8 parts, L-ascorbic acid 0.4 parts, riboflavin 0.008 parts, thiamine nitrate 0.005 parts, food flavoring 2.0 parts, and sweetener 0.2 parts.

[0059] The dietary fiber is orange powder and fructooligosaccharides, with 6 parts orange powder and 11 parts fructooligosaccharides; the sweetener is 4,1,6-trichlorodeoxygalactosyl sucrose; the acidulant is citric acid; the potassium is potassium chloride; the inorganic salts are 1 part magnesium chloride and 0.8 parts calcium salt; the food flavoring is L-arginine; and the sweetener is acesulfame potassium.

[0060] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salts, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring, and sweetener to make 5g / bag.

[0061] The method of consumption includes the following steps: Take one packet each time, mix it with 150ml of warm water, or add it to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume 2-3 times a day.

[0062] Example 4:

[0063] A special potassium-supplementing diet is composed of the following substances in parts by weight: trehalose 43 parts, potassium 26 parts, dietary fiber 13 parts, konjac flour 10 parts, acidulant 2.5 parts, inorganic salts 1.8 parts, L-ascorbic acid 0.4 parts, riboflavin 0.008 parts, thiamine nitrate 0.015 parts, food flavoring 2.0 parts, and sweetener 0.25 parts.

[0064] The dietary fiber is made from orange powder and fructooligosaccharides, with 4 parts orange powder and 9 parts fructooligosaccharides. The sweetener is arugula saccharin; the acidulant is citric acid; the potassium is potassium citrate; and the inorganic salt is a combination of 0.8 parts sodium chloride and 1 part magnesium chloride. The food flavoring is L-arginine, and the sweetener is acesulfame potassium.

[0065] The method for preparing the potassium-supplemented special diet includes mixing trehalose, potassium, dietary fiber, konjac flour, acidulant, inorganic salts, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring, and sweetener to make 5g / bag.

[0066] The method of consuming this potassium-supplementing special dietary supplement includes the following steps: Take one packet each time, mix it with 150ml of warm water, or add it to other non-carbonated beverages or porridge and mix well before consuming. It is recommended to consume it 2-3 times a day.

[0067] The potassium-supplemented special diets prepared in the above embodiments were subjected to compliance testing (specific testing methods are described in "Investigation on Dietary Compliance of Patients with Chronic Kidney Disease during Follow-Up" and "Dietary Compliance in Clinical Trials of Nutrition and Behavioral Interventions," which are incorporated herein by reference in their entirety). The results are shown in Table 1:

[0068] Table 1. Results of potassium supplementation-specific dietary adherence.

[0069] Example Dosage Results of taking the medication Organ impact control group Oral potassium supplement tablets Not sweet It is highly irritating to the gastrointestinal tract and causes significant pain. Example 1 Dissolve medicine Slightly sweet Side effects are minimal and negligible. Comparative Example 1 Dissolve in water to make medicine Slightly sweet Side effects are minimal and negligible. Comparative Example 2 Dissolve in water to make medicine Slightly sweet Side effects are minimal and negligible. Comparative Example 3 Dissolve in water to make medicine Slightly sweet Side effects are minimal and negligible. Comparative Example 4 Dissolve in water to make medicine Slightly sweet Side effects are minimal and negligible. Example 2 Dissolve in water to make medicine Slightly sweet Side effects are minimal and negligible. Example 3 Dissolve medicine Slightly sweet Side effects are minimal and negligible. Example 4 Dissolve medicine Slightly sweet Side effects are minimal and negligible.

[0070] The bioavailability of potassium-supplemented special dietary foods prepared in the above embodiments was tested (for specific test methods, please refer to "Partial substitution of sodium with potassiumin white bread: feasibility and bioavailability", the full text of which is incorporated herein by reference). The results are shown in Table 2:

[0071] Table 2 Results of bioavailability of potassium in special potassium-supplementing diets

[0072]

[0073]

[0074] In summary, the present invention includes the following technical features:

[0075] 1. Vitamin B1 participates in redox reactions during metabolism and enhances cellular metabolic function, maintaining normal carbohydrate and fat metabolism. A deficiency in vitamin B1 can impair the body's absorption and utilization of potassium ions, increasing the risk of hypokalemia.

[0076] 2. Vitamin B2 participates in biological oxidation and energy production in the body, and as a coenzyme for many important enzymes, it participates in a variety of physiological processes in the human body.

[0077] 3. Dietary fiber: It uses factory-customized gelatinous fiber and insoluble fiber, which not only protects against the irritation of potassium ions on the gastrointestinal mucosa, but also greatly improves the taste.

[0078] 4. Vitamins can promote the body's absorption and utilization of potassium, which helps maintain electrolyte balance in the body.

[0079] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0080] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

[0081] The above technical solutions only embody the preferred technical solutions of the present invention. Any modifications that may be made by those skilled in the art to certain parts thereof embody the principles of the present invention and fall within the protection scope of the present invention.

Claims

1. A special potassium-supplementing diet, characterized in that, It is mainly composed of the following substances in parts by weight: trehalose 42-43.5 parts, potassium 24-26 parts, dietary fiber 13-17 parts, konjac flour 9-11 parts, acidulant 1.6-3 parts, inorganic salts 1.5-1.8 parts, L-ascorbic acid 0.3-0.4 parts, riboflavin 0.005-0.008 parts, thiamine nitrate 0.005-0.015 parts, food flavoring 1.8-2.0 parts, and sweetener 0.19-0.25 parts.

2. The potassium-supplementing special diet according to claim 1, characterized in that, The dietary fiber includes one or more of orange powder, fructooligosaccharides, glucan, or polydextrose.

3. A special potassium-supplementing diet according to claim 2, characterized in that, The dietary fiber is selected from orange powder and fructooligosaccharides, with the orange powder being 4-6 parts and the fructooligosaccharides being 9-11 parts.

4. The potassium-supplementing special diet according to claim 1, characterized in that, The sweetener comprises one or more of 4,1,6-trichlorodeoxygalactosucrose, cyclohexylsulfamic acid, semathymidine, acesulfame potassium, o-benzoylsulfonamide, or hesperidin.

5. A special potassium-supplementing diet according to claim 1, characterized in that, The acidulant includes one or more of citric acid, sodium citrate, lactic acid, phosphoric acid, tartaric acid, or malic acid.

6. A special potassium-supplementing diet according to claim 1, characterized in that, The potassium includes potassium chloride, potassium citrate, and / or potassium magnesium aspartate.

7. A special potassium-supplementing diet according to claim 1, characterized in that, The inorganic salt includes one or more of sodium chloride, magnesium chloride, sodium bicarbonate, or calcium salts.

8. A method for preparing a potassium-supplementing special diet according to any one of claims 1-7, characterized in that, The preparation method includes: mixing trehalose, potassium, dietary fiber, konjac powder, orange powder, acidulant, inorganic salt, L-ascorbic acid, riboflavin, thiamine nitrate, food flavoring and sweetener.

9. A special potassium-supplementing diet, characterized in that, It is obtained by the preparation method described in claim 8.

10. The use of the potassium-supplemented special diet according to any one of claims 1-7 or claim 9 in the preparation of health foods and / or potassium supplements that help protect the gastric mucosa.

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