Traditional Chinese medicine composition for improving AIDS (acquired immune deficiency syndrome) skin itch and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for improving AIDS (acquired immune deficiency syndrome) skin itch and a preparation method of the traditional Chinese medicine composition. The first composition comprises American ginseng, sticktight, gynostemma pentaphylla, lithospermum, centipede, scorpion, rhizoma smilacis glabrae, polygala fallax hemsl, cicada slough, stiff silkworm, medlar and wintercreeper; the second composition comprises euonymus fortunei, scandent schefflera stem and leaf, gynostemma pentaphylla, honeysuckle, cortex dictamni, fructus kochiae, sticktight, lithospermum erythrorhizon and fructus gardeniae. Compared with the prior art, through combination of oral administration and external use, the traditional Chinese medicine has the effects of externally preventing skin emergency, relieving exogenous evil burden of a body and internally repairing the body for strengthening defensive qi, so that treatment and prevention are integrated.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a traditional Chinese medicine composition for improving skin itching in AIDS patients and its preparation method. Background Technology

[0002] Acquired Immunodeficiency Syndrome (AIDS), also known as AIDS, is a fatal infectious disease caused by the Human Immunodeficiency Virus (HIV). AIDS patients have severely compromised immune systems, making them susceptible to opportunistic infections. For example, skin and mucous membrane lesions, commonly known as AIDS-related pruritus, are a common complication of AIDS. Studies show that 90% of HIV-infected individuals or AIDS patients develop skin lesions due to pruritus during the course of the disease. These lesions are classified as infectious lesions such as herpes zoster, herpes simplex, warts, fungal infections, and bacterial infections, and non-infectious lesions such as seborrheic dermatitis, ichthyosis, and pityriasis rubra pilaris. Pruritus is primarily caused by lesions in the skin and mucous membranes, and these manifestations are closely related to the progression of HIV infection and the body's immune function.

[0003] Because a significant number of HIV patients experience skin lesions with itching as the initial symptom, primarily manifesting as chronic, persistent, and refractory pruritus, which may occur without skin lesions or with lesions of varying sizes and shapes, and because almost all HIV patients experience different forms and degrees of related skin diseases at different stages of HIV infection, with some even developing exfoliative papules and cicatricial nodules due to excessive scratching, impacting daily life, increasing psychological burden, and reducing the will to live, alleviating pruritus in HIV-positive individuals is of great significance.

[0004] Currently, Western medicine mainly uses conventional symptomatic treatment methods to treat itchy skin in clinical practice. Although this can relieve a certain symptom, it accelerates the patient's physical exhaustion and is not conducive to long-term treatment. In contrast, traditional Chinese medicine has shown obvious advantages in treating this disease through syndrome differentiation and treatment. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for improving pruritus in patients with AIDS and its preparation method. This aims to address the limitations of Western medicine in providing long-term treatment for pruritus in AIDS patients, as existing traditional Chinese medicine prescriptions mainly focus on oral medications and cannot promptly relieve the suffering of patients with pruritus.

[0006] To achieve the above objectives, the present invention provides a traditional Chinese medicine composition for improving skin itching associated with AIDS, comprising a first composition and a second composition. The first composition includes: American ginseng, Bidens pilosa, Gynostemma pentaphyllum, Lithospermum erythrorhizon, centipede, scorpion, Smilax glabra, Hedyotis diffusa, cicada molting, Bombyx mori, wolfberry, and Euonymus fortunei.

[0007] The second composition includes: Euonymus fortunei, Schefflera heptaphylla, Gynostemma pentaphyllum, Lonicera japonica, Dictamnus dasycarpus, Kochia scoparia, Bidens pilosa, Lithospermum erythrorhizon, and Gardenia jasminoides.

[0008] Preferably, in the above technical solution, the first composition, by weight, comprises: 10-20g American ginseng, 15-25g Bidens pilosa, 15-25g Gynostemma pentaphyllum, 10-20g Lithospermum erythrorhizon, several centipedes, 5-10g scorpion, 25-35g Smilax glabra, 25-35g Hedyotis diffusa, 5-10g cicada slough, 10-20g Bombyx mori, 15-25g wolfberry, and 10-20g Euonymus fortunei.

[0009] Preferably, in the above technical solution, by weight, the first composition mainly consists of 15g American ginseng, 20g Bidens pilosa, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 30g Lysimachia christinae, 8g cicada slough, 15g Bombyx mori, 20g wolfberry, and 15g Euonymus fortunei.

[0010] Preferably, in the above technical solution, the second composition, by weight, comprises: 10-20g of Euonymus fortunei, 25-35g of Schefflera heptaphylla, 25-35g of Gynostemma pentaphyllum, 10-20g of Lonicera japonica, 15-25g of Dictamnus dasycarpus, 25-35g of Kochia scoparia, 15-25g of Bidens pilosa, 10-20g of Lithospermum erythrorhizon, and 5-10g of Gardenia jasminoides.

[0011] Preferably, in the above technical solution, the second composition, by weight, mainly consists of 15g of Euonymus fortunei, 30g of Schefflera heptaphylla, 30g of Gynostemma pentaphyllum, 15g of Lonicera japonica, 20g of Dictamnus dasycarpus, 30g of Kochia scoparia, 20g of Bidens pilosa, 15g of Lithospermum erythrorhizon and 8g of Gardenia jasminoides.

[0012] The medicinal properties and effects of each component in the traditional Chinese medicine composition of this invention are as follows: American ginseng: The dried root of a perennial herbaceous plant belonging to the genus Panax in the family Araliaceae. It has a sweet and slightly bitter taste and is cool in nature; it enters the heart, lung, and kidney meridians. American ginseng has the effects of nourishing lung yin, clearing deficiency fire, and promoting body fluid production and quenching thirst. It is mainly used to treat symptoms such as chronic cough due to lung deficiency, blood loss, dry throat and thirst, and fatigue due to deficiency heat.

[0013] Bidens pilosa: The dried whole herb of Bidens pilosa, belonging to the genus Bidens in the family Asteraceae. It has a bitter taste and slightly cold nature; it enters the liver, lung, and large intestine meridians. Bidens pilosa has the effects of clearing heat and detoxifying, dispersing blood stasis and reducing swelling, and is mainly used to treat sores caused by heat toxins, sore throat, and traumatic injuries.

[0014] Gynostemma pentaphyllum: The dried whole herb of Gynostemma pentaphyllum, a plant of the Cucurbitaceae family. It has a bitter taste and is cold in nature. Gynostemma pentaphyllum has the effects of clearing heat and detoxifying, antibacterial and anti-inflammatory, relieving cough and eliminating phlegm. It is mainly used to treat symptoms such as qi deficiency and yin deficiency, lung heat and thick phlegm, cough and asthma, palpitations and insomnia.

[0015] Purple gromwell root: It has a sweet and salty taste, and is cold in nature; it enters the heart and liver meridians. Purple gromwell root has the effects of cooling the blood and promoting blood circulation, detoxifying and relieving rashes, and is mainly used to treat diseases such as blood heat and toxicity, purplish-black rashes, sores and eczema.

[0016] Centipede: It has a pungent taste and warm properties; it enters the liver meridian. Centipede has the effects of extinguishing wind and stopping spasms, clearing the meridians and relieving pain, and attacking toxins and dispersing nodules. It is mainly used to treat infantile convulsions, rheumatic pain, sores and carbuncles.

[0017] Scorpion: pungent in flavor and neutral in nature; enters the liver meridian. Scorpion has the effects of calming wind and stopping spasms, attacking toxins and dispersing nodules. It is mainly used to treat skin itching, skin pain, stubborn rheumatism, facial paralysis due to stroke, hemiplegia, epilepsy and other diseases.

[0018] Smilax glabra: sweet and bland in taste, neutral in nature; enters the liver and stomach meridians. Smilax glabra has the effects of detoxifying and removing dampness, and promoting joint mobility. It is mainly used to treat damp-heat sores, eczema, herpes zoster and other diseases.

[0019] Yellow Water Lily: Sweet and slightly bitter in taste, neutral in nature; enters the liver, spleen, and kidney meridians. Yellow Water Lily has the effects of clearing heat and detoxifying, reducing inflammation and relieving pain, replenishing qi and blood, and protecting the liver. It is mainly used to treat fatigue, sore throat, oral ulcers, and other symptoms.

[0020] Cicada molting: sweet in taste and cold in nature; enters the lung and liver meridians. Cicada molting has the effects of dispersing wind-heat, relieving sore throat and promoting rash eruption, improving eyesight and clearing away corneal opacity, calming wind and stopping spasms. It is mainly used to treat wind-heat syndrome, sore throat, measles that fail to erupt, infantile convulsions and other diseases.

[0021] Silkworm: It tastes salty and pungent, is neutral in nature, and is non-toxic. It enters the liver, heart, spleen, and lung meridians. Silkworm has the effects of extinguishing wind, stopping spasms and relieving pain, dispelling wind-heat, resolving phlegm and relieving cough, activating blood circulation and unblocking meridians, and detoxifying and dispersing nodules. It is mainly used to treat infantile convulsions, sore throat, itchy throat and dry cough, itchy skin, febrile asthma, breast lumps, submandibular lymphadenitis and other diseases.

[0022] Goji berries: sweet in taste and neutral in nature; they enter the liver and kidney meridians. Goji berries nourish the liver and kidneys, moisten the lungs and relieve cough, nourish blood and calm the mind. They are mainly used to treat syndromes such as liver and kidney yin deficiency and insufficient essence and blood. Components such as goji berry polysaccharides and betaine help protect liver cells. Euonymus fortunei: The dried stems and leaves of Euonymus fortunei, a plant in the Celastraceae family. It has a pungent taste and neutral properties; it enters the liver, spleen, and kidney meridians. Euonymus fortunei has the effects of clearing heat and detoxifying, relaxing muscles and tendons, resolving blood stasis and reducing swelling, stopping bleeding and promoting tissue regeneration. It is mainly used to treat symptoms such as sore throat, hemoptysis, oral ulcers, traumatic bleeding, and sores and swelling.

[0023] Schefflera heptaphylla: The dried stems and leaves of a plant in the Araliaceae family, genus Schefflera. It has a pungent and slightly bitter taste, and is warm in nature; it enters the liver and kidney meridians. Schefflera heptaphylla has the effects of dispelling wind and dampness, promoting blood circulation and relieving pain, and relaxing muscles and tendons. It is mainly used to treat rheumatic pain, traumatic injuries, stomachache, and other symptoms.

[0024] Dictamnus dasycarpus root bark: The root bark of Dictamnus dasycarpus and Dictamnus angustifolia, both perennial herbs belonging to the Rutaceae family. It is bitter and cold in nature; it enters the spleen, stomach, and bladder meridians. Dictamnus dasycarpus root bark has the effects of clearing heat and drying dampness, dispelling wind and detoxifying. It is mainly used to treat damp-heat sores, weeping eczema, urticaria, scabies, and rheumatic arthralgia.

[0025] Kochia scoparia fruit: The dried, ripe fruit of the Kochia scoparia plant (family Chenopodiaceae). It tastes bitter and is cold in nature; it enters the kidney and bladder meridians. Kochia scoparia fruit has the effects of clearing heat and dampness, dispelling wind and relieving itching, and is mainly used to treat urinary problems, itchy skin, eczema and other ailments.

[0026] Gardenia: The dried, ripe fruit of the gardenia plant (family Rubiaceae). It has a bitter taste and is cold in nature; it enters the heart, lung, and triple burner meridians. Gardenia has the effects of purging heat and relieving irritability, clearing heat and promoting diuresis, cooling blood and detoxifying, and is mainly used to treat heat syndromes, damp-heat syndromes, and bleeding due to blood heat in traditional Chinese medicine.

[0027] To achieve the above objectives, the present invention also provides a method for preparing a traditional Chinese medicine composition for improving skin itching in patients with HIV / AIDS, the steps of which are as follows: S1. Take centipede and scorpion and stir-fry over low heat until crisp. After stir-frying, bring the centipede, scorpion and cicada molting to a boil over high heat and then simmer over low heat for 20-30 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water and bring to a boil over high heat. Then simmer over low heat for 10-15 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, wolfberry and Hedyotis diffusa and simmer over low heat for 20-30 minutes. Filter and take the filtrate. Add water to the residue and simmer for 15-20 minutes. Filter and take the filtrate. Mix the two filtrates to obtain the first composition solution. S2, the second composition is pulverized into medicinal powder, the medicinal powder is extracted by percolation to obtain an extract, concentrated, centrifuged, filtered to obtain a concentrated extract, the concentrated extract is mixed with a gel matrix, phenoxyethanol and vitamin E are added and mixed, filtered to obtain a topical gel.

[0028] Preferably, in the above technical solution, in step S2, the second composition is pulverized into medicinal powder, the medicinal powder is extracted by percolation to obtain an extract, concentrated, centrifuged, and filtered to obtain a concentrated extract, the concentrated extract is mixed with a gel matrix, phenoxyethanol and vitamin E are added and mixed, and then filtered to obtain a topical gel. The specific steps are as follows: S21. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 10-20 mesh powder. Soak the powder in a solvent. Fill the soaked powder into a percolation cylinder and soak for 2-3 hours. Adjust the flow rate to 1-3 mL / min and percolate to obtain an extract. Concentrate the extract and dilute it with purified water. Centrifuge and collect the supernatant. Filter the supernatant through a microporous membrane to obtain a concentrated extract. S22, prepare a gel matrix by taking carbomer, triglycerides and azone; S23, the extract concentrate is added to the gel matrix and mixed, then preservatives and vitamin E are added, and mixing continues. The mixture is then filtered through a microporous membrane to obtain a topical gel.

[0029] Preferably, in the above technical solution, the solvent is a 70%-80% aqueous ethanol solution.

[0030] Preferably, in the above technical solution, the preservative is phenoxyethanol or methylparaben.

[0031] The main symptoms of AIDS-related skin itching include fever, cough, irritability, insomnia, shortness of breath, palpitations, dizziness, dry mouth and tongue, small or patchy rashes, shingles from the navel to the chest, persistent oral ulcers, and itchy, red skin. Physical examination typically reveals a dry, red tongue with little or no coating, and a floating, rapid, or wiry pulse. From a Traditional Chinese Medicine (TCM) perspective, the pathogenesis is rooted in internal heat disturbance and depletion of Yin fluids, with liver fire and accumulated heat in the heart and spleen as secondary manifestations, compounded by Qi deficiency. The cause is that heat easily damages blood vessels, leading to poor blood circulation; Qi deficiency weakens the body's defensive capabilities, and the stagnation of heat in the skin easily generates "wind-heat." In response to the above-mentioned causes, a treatment strategy of clearing the root cause of the disease internally and eliminating the symptoms externally is proposed. Specifically, internally, it is necessary to clear internal pathogens, replenish vital energy, and strengthen the body's foundation. The effects of oral Chinese medicine formulas are to clear heat, detoxify, remove dampness, cool blood, promote blood circulation, replenish qi, dispel wind, and strengthen the body's foundation. Externally, it is necessary to dispel wind, detoxify, and disperse nodules. The effects of external medicine formulas are to antibacterial, anti-inflammatory, detoxify, disperse nodules, dispel wind, and relieve itching. The combination of internal and external treatments aims to simultaneously reduce the body's "burden of external pathogens" by preventing acute skin diseases externally and to repair the body's defenses internally.

[0032] Compared with the prior art, the beneficial effects of this application are as follows: (1) After analyzing the symptoms, signs and syndromes of AIDS pruritus to determine its etiology and pathogenesis, based on the etiology and pathogenesis of AIDS pruritus and the principles of Chinese medicine compatibility, we obtained an internal and external prescription that can relieve AIDS pruritus. The combination of internal and external treatments can simultaneously prevent acute skin diseases and reduce the body's "external evil burden" and repair the body's defense function. (2) The combination of the oral and external formulations of this formula has been clinically proven to be effective. The oral formulation uses Smilax glabra and Eupatorium fortunei as the principal herbs, Euonymus fortunei, Panax quinquefolius, Bidens pilosa, Gynostemma pentaphyllum, Lithospermum erythrorhizon, Bombyx mori, Scolopendra subspinipes and Scorpio as the assistant herbs, Lycium barbarum as the adjuvant herbs, and Cicadae periostracum as the guiding herb. Smilax glabra detoxifies, removes dampness, and dispels pathogens; Hedyotis diffusa tonifies qi, strengthens blood, and reduces inflammation. Together, they work to strengthen the body's resistance, expel pathogens, and consolidate the defensive qi. Cicada slough promotes rash eruption and detoxifies; Lithospermum erythrorhizon cools blood and detoxifies; Scolopendra subsides wind and relieves itching; Scorpion clears the meridians and disperses nodules; Gynostemma pentaphyllum and Bidens pilosa clear heat and detoxify, enhancing the effects of Smilax glabra in removing dampness, dispelling pathogens, detoxifying, and dispersing nodules. American ginseng tonifies qi and nourishes yin; Gynostemma pentaphyllum invigorates qi and strengthens the spleen, assisting Hedyotis diffusa in tonifying qi and strengthening the body's resistance. Together, they enhance the effects of strengthening the body's resistance, expelling pathogens, and consolidating the defensive qi. Goji berries harmonize the other herbs; their sweet and moistening properties counteract the potent toxicity of Scolopendra and Scorpion, as well as the cooling and drying properties of American ginseng and Lithospermum erythrorhizon, thus moderating the medicinal properties and preventing harm to the body's resistance. Cicada slough guides the medicinal power to the body surface, enhancing the effects of promoting rash eruption and detoxifying. The external application formula uses seven-leaf lotus, kochia fruit, and gynostemma pentaphyllum as the principal herbs, honeysuckle, dictamnus root bark, beggar-ticks, gromwell root, and gardenia as the assistant herbs, and euonymus fortunei as the guiding herb. The principal herbs dispel dampness, wind, and detoxify, the assistant herbs clear heat, dry dampness, cool blood, and resolve blood stasis, and the guiding herbs enhance the penetration of the ingredients and improve skin circulation. (3) The modern medical principle of the topical composition is as follows: The extract contains aesculin, kochia saponin, shikonin, quercetin, chlorogenic acid, isochlorogenic acid, dictamnus alkaloid, gynostemma pentaphyllum saponin, geniposide, etc. Among them, chlorogenic acid, isochlorogenic acid, gynostemma pentaphyllum saponin, etc. inhibit the growth and reproduction of pathogenic bacteria; dictamnus alkaloid, aesculin, shikonin, etc. can inhibit the release of inflammatory factors, reduce itching caused by inflammatory factor stimulation and alleviate skin inflammation; geniposide, quercetin, beggar-ticksine inhibit the release of pruritus mediators and relieve itching stimulation. Attached Figure Description

[0033] The realization of the objective, functional features and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings.

[0034] Figure 1 These are pictures of an AIDS patient with pruritus before treatment. Figure 2 yes Figure 1 Images of the condition of AIDS patients with itchy skin after treatment. Detailed Implementation

[0035] The technical solutions in the embodiments of this invention are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0036] Both the centipedes and scorpions were purchased from Guangxi Baokangyuan Pharmaceutical Co., Ltd. Example 1

[0037] A traditional Chinese medicine composition for improving skin itching associated with HIV / AIDS, the composition comprising a first composition and a second composition. The first composition mainly consists of 10-20g American ginseng, 15-25g Bidens pilosa, 15-25g Gynostemma pentaphyllum, 10-20g Lithospermum erythrorhizon, several centipedes, 5-10g scorpion, 25-35g Smilax glabra, 25-35g Hedyotis diffusa, 5-10g cicada slough, 10-20g Bombyx mori, 15-25g wolfberry, and 10-20g Euonymus fortunei. The second composition mainly consists of 10-20g of Euonymus fortunei, 25-35g of Acer palmatum, 25-35g of Gynostemma pentaphyllum, 10-20g of Lonicera japonica, 15-25g of Dictamnus dasycarpus, 25-35g of Kochia scoparia, 15-25g of Bidens pilosa, 10-20g of Lithospermum erythrorhizon and 5-10g of Gardenia jasminoides.

[0038] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients is as follows: S1, Preparation of oral preparation: Take centipede, remove head and feet, and scorpion, remove head, feet and tail spine. Stir-fry over low heat until crisp. Boil the stir-fried centipede, scorpion and cicada molting over high heat, then simmer over low heat for 20-30 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water, boil over high heat, then simmer over low heat for 10-15 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, Lycium barbarum and Hedyotis diffusa, then simmer over low heat for 20-30 minutes. Filter, take the filtrate, add water to the residue and decoct for 15-20 minutes, filter, take the filtrate, mix the filtrates to obtain the oral preparation. S2, the steps for preparing the topical gel are as follows: S21. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 10-20 mesh powder. Soak the powder in a 70%-80% ethanol aqueous solution for 1-2 hours. Fill the soaked powder into a percolator and soak for 2-3 hours. Open the valve and adjust the flow rate to 1-3 mL / min. Percolate for 6-8 hours to obtain an extract. Concentrate the extract at 50-55℃ and 0.06-0.08 MPa to obtain an ethanol-free concentrate. Dilute the concentrate with purified water at 3000-4000 r / min and centrifuge for 10-15 min. Take the supernatant and filter it through a 0.22 μm microporous membrane to obtain the concentrated extract. S22, Carbomer 940 is added to purified water at a speed of 100-200 r / min and stirred for 60-120 min. Then, triglycerides and azone are added and stirred for 10-15 min. The pH is adjusted to 6.5-7.3 to obtain a gel matrix. The pH adjuster used to adjust the pH is triethanolamine. S23, the extract concentrate is added to the gel matrix and stirred for 10-15 minutes at a speed of 300-400 r / min. Then, phenoxyethanol and vitamin E are added and stirred for another 10 minutes. The mixture is then filtered under reduced pressure using a 0.22 μm microporous membrane to obtain a topical gel. Example 2

[0039] A traditional Chinese medicine composition for improving skin itching associated with HIV / AIDS, the composition comprising a first composition and a second composition. The first composition mainly consists of 15g American ginseng, 20g Bidens pilosa, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 30g Lysimachia christinae, 8g cicada slough, 15g Bombyx mori, 20g wolfberry and 15g Euonymus fortunei. The second composition mainly consists of 15g Euonymus fortunei, 30g Acer palmatum, 30g Gynostemma pentaphyllum, 15g Lonicera japonica, 20g Dictamnus dasycarpus, 30g Kochia scoparia, 20g Bidens pilosa, 15g Lithospermum erythrorhizon and 8g Gardenia jasminoides.

[0040] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients is as follows: S1, Preparation of oral preparation: Take centipede, remove head and feet, and scorpion, remove head, feet and tail spine. Stir-fry over low heat until crisp. Boil the stir-fried centipede, scorpion and cicada molting over high heat, then simmer over low heat for 30 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water, boil over high heat, then simmer over low heat for 13 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, Lycium barbarum and Hedyotis diffusa, then simmer over low heat for 25 minutes. Filter, take the filtrate, add water to the residue and simmer for 15 minutes. Filter, take the filtrate, mix the filtrates to obtain the oral preparation. S2, the steps for preparing the topical gel are as follows: S21. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 20-mesh powder. Soak the powder in 80% ethanol aqueous solution for 2 hours. Fill the soaked powder into a percolator and soak for 3 hours. Open the valve and adjust the flow rate to 3 mL / min. Percolate for 8 hours to obtain an extract. Concentrate the extract at 55℃ and 0.08 MPa to obtain an ethanol-free concentrate. Dilute the concentrate with purified water and centrifuge at 4000 r / min for 13 min. Take the supernatant and filter it through a 0.22 μm microporous membrane to obtain the concentrated extract. S22, Carbomer 940 was added to purified water at a speed of 200 r / min and stirred for 70 min. Then, triglycerides and azone were added and stirred for 15 min. The pH was adjusted to 6.5-7.3 to obtain a gel matrix. The pH adjuster used to adjust the pH was triethanolamine. S23, the extract concentrate is added to the gel matrix and stirred for 15 min at a speed of 400 r / min. Then, phenoxyethanol and vitamin E are added and stirred for another 10 min. The mixture is then filtered under reduced pressure using a 0.22 μm microporous membrane to obtain a topical gel. Example 3

[0041] A traditional Chinese medicine composition for improving skin itching associated with HIV / AIDS, the composition comprising a first composition and a second composition. The first composition mainly consists of 15g American ginseng, 20g Bidens pilosa, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 30g Lysimachia christinae, 8g cicada slough, 15g Bombyx mori, 20g wolfberry and 15g Euonymus fortunei. The second composition mainly consists of 15g Euonymus fortunei, 30g Acer palmatum, 30g Gynostemma pentaphyllum, 15g Lonicera japonica, 20g Dictamnus dasycarpus, 30g Kochia scoparia, 20g Bidens pilosa, 15g Lithospermum erythrorhizon and 8g Gardenia jasminoides.

[0042] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients is as follows: S1, Preparation of oral preparation: Take centipede, remove head and feet, and scorpion, remove head, feet and tail spine. Stir-fry over low heat until crisp. Boil the stir-fried centipede, scorpion and cicada molting over high heat, then simmer over low heat for 20 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water, boil over high heat, then simmer over low heat for 10 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, Lycium barbarum and Hedyotis diffusa, then simmer over low heat for 20 minutes. Filter, take the filtrate, add water to the residue and simmer for 15 minutes. Filter, take the filtrate, mix the filtrates to obtain the oral preparation. S2, the steps for preparing the topical gel are as follows: S21. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 10-mesh powder. Soak the powder in 80% ethanol aqueous solution for 1 hour. Fill the soaked powder into a percolation cylinder and soak for 3 hours. Open the valve and adjust the flow rate to 1 mL / min. Percolate for 6 hours to obtain an extract. Concentrate the extract at 55℃ and 0.06 MPa to obtain an ethanol-free concentrate. Dilute the concentrate with purified water and centrifuge at 4000 r / min for 15 min. Take the supernatant and filter it through a 0.22 μm microporous membrane to obtain the concentrated extract. S22, Carbomer 940 is added to purified water at a speed of 100 r / min and stirred for 100 min. Then, triglycerides and azone are added and stirred for 10 min. The pH is adjusted to 6.5-7.3 to obtain a gel matrix. The pH adjuster used to adjust the pH is triethanolamine. S23, the extract concentrate is added to the gel matrix and stirred for 10 min at a speed of 300 r / min. Then, phenoxyethanol and vitamin E are added and stirred for another 10 min. The mixture is then filtered under reduced pressure using a 0.22 μm microporous membrane to obtain a topical gel.

[0043] Comparative Example 1 Compared with Example 2, the difference is that the second composition is missing. A traditional Chinese medicine composition for improving pruritus in AIDS patients, the traditional Chinese medicine composition comprising 15g American ginseng, 20g Bidens pilosa, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 30g Liriope muscari, 8g cicada slough, 15g Bombyx mori, 20g Lycium barbarum, and 15g Euonymus fortunei.

[0044] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients includes the following steps: Remove the head and feet of the centipede and the head, feet, and tail spines of the scorpion. Stir-fry over low heat until crisp. Bring the stir-fried centipede, scorpion, and cicada molting to a boil over high heat, then simmer over low heat for 30 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus, and water. Bring to a boil over high heat, then simmer over low heat for 13 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, Lycium barbarum, and Hedyotis diffusa. Simmer over low heat for 25 minutes. Filter and collect the filtrate. Add water to the residue and simmer for 15 minutes. Filter and collect the filtrate. Mix the filtrates to obtain an oral preparation.

[0045] Comparative Example 2 Compared with Example 2, the difference is that the first composition lacks Bidens pilosa, centipede, scorpion, and *Hedyotis diffusa*, while the second composition lacks *Aristolochia debilis*, *Euonymus fortunei*, Bidens pilosa, and gardenia. A traditional Chinese medicine composition for improving skin itching in AIDS patients, the traditional Chinese medicine composition comprising the first composition and the second composition, The first composition mainly consists of 15g American ginseng, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 30g Smilax glabra, 15g Bombyx mori, 20g Lycium barbarum, 8g Cicadae periostracum and 15g Euonymus fortunei. The second composition mainly consists of 30g of Gynostemma pentaphyllum, 15g of Lonicera japonica, 20g of Dictamnus dasycarpus root bark, 30g of Kochia scoparia fruit, and 15g of Lithospermum erythrorhizon.

[0046] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients is as follows: S1, Preparation of oral preparation: Take American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water, bring to a boil over high heat, then simmer over low heat for 13 minutes. Add Lithospermum erythrorhizon and Lycium barbarum and simmer over low heat for 25 minutes. Filter, take the filtrate, add water to the residue and simmer for 15 minutes. Filter, take the filtrate, mix the filtrates to obtain the oral preparation. S2, the steps for preparing the topical gel are as follows: S21. Take Kochia scoparia, Gynostemma pentaphyllum, Dictamnus dasycarpus, Lithospermum erythrorhizon, and Lonicera japonica, and pulverize them into 20-mesh powder. Soak the powder in 80% ethanol aqueous solution for 2 hours. Fill the soaked powder into a percolator and soak for 3 hours. Open the valve and adjust the flow rate to 3 mL / min. Percolate for 8 hours to obtain an extract. Concentrate the extract at 55℃ and 0.08 MPa to obtain an ethanol-free concentrate. Dilute the concentrate with purified water and centrifuge at 4000 r / min for 13 min. Take the supernatant and filter it through a 0.22 μm microporous membrane to obtain the concentrated extract. S22 and S23 are the same as in Example 2.

[0047] Comparative Example 3 Compared with Example 2, the difference lies in that the first composition lacks *Gnaphalium affine*, *Bidens pilosa*, *Gynostemma pentaphyllum*, and *Euonymus fortunei*, while the second composition lacks *Dictamnus dasycarpus*, *Acer pentaphyllum*, *Lithospermum erythrorhizon*, and *Bidens pilosa*. A traditional Chinese medicine composition for improving skin itching in AIDS patients, the traditional Chinese medicine composition comprising the first composition and the second composition, The first composition mainly consists of 15g American ginseng, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 8g cicada slough, 15g silkworm pupa, and 20g wolfberry. The second composition mainly consists of 15g of Euonymus fortunei, 30g of Gynostemma pentaphyllum, 15g of Lonicera japonica, 30g of Kochia scoparia, and 8g of Gardenia jasminoides.

[0048] The preparation method is the same as in Example 2.

[0049] Comparative Example 4 Compared with Example 2, the difference is that the first composition is missing. A traditional Chinese medicine composition for improving skin itching in AIDS patients, the composition mainly consists of 15g of Euonymus fortunei, 30g of Achyranthes bidentata, 30g of Gynostemma pentaphyllum, 15g of Lonicera japonica, 20g of Dictamnus dasycarpus, 30g of Kochia scoparia, 20g of Bidens pilosa, 15g of Lithospermum erythrorhizon and 8g of Gardenia jasminoides.

[0050] The preparation method of the above-mentioned traditional Chinese medicine composition for improving skin itching in AIDS patients includes the following steps: S1. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 20-mesh powder. Soak the powder in 80% ethanol aqueous solution for 2 hours. Fill the soaked powder into a percolator and soak for 3 hours. Open the valve and adjust the flow rate to 3 mL / min. Percolate for 8 hours to obtain an extract. Concentrate the extract at 55℃ and 0.08 MPa to obtain an ethanol-free concentrate. Dilute the concentrate with purified water and centrifuge at 4000 r / min for 13 min. Take the supernatant and filter it through a 0.22 μm microporous membrane to obtain the concentrated extract. S2, Carbomer 940 was added to purified water at a speed of 200 r / min and stirred for 70 min. Then, triglycerides and azone were added and stirred for 15 min. The pH was adjusted to 6.5-7.3 to obtain a gel matrix. The pH adjuster used to adjust the pH was triethanolamine. S3, the extract concentrate is added to the gel matrix and stirred for 15 min at a speed of 400 r / min. Then, phenoxyethanol and vitamin E are added and stirred for another 10 min. The mixture is then filtered under reduced pressure using a 0.22 μm microporous membrane to obtain the external gel.

[0051] I. Clinical Trials (1) Test subjects This study included 287 AIDS patients with pruritus. It was conducted using a completely randomized, controlled, double-blind method, and the patients, intervention operators, and statisticians were all blinded.

[0052] (2) Treatment methods Control group: Loratadine capsules were taken once before bedtime, and 999 Piyanping ointment was applied topically; Experimental group: The oral medication and topical gel prepared in Example 2, Comparative Example 2, and Comparative Example 3 were administered orally (200 mL each time) after breakfast, lunch, and dinner. The topical gel was applied 4-6 times daily, with the frequency adjusted according to the patient's condition. The oral medication prepared in Comparative Example 1 was administered orally (200 mL each time) after breakfast, lunch, and dinner. The topical gel prepared in Comparative Example 4 was applied 4-6 times daily, with the frequency adjusted according to the patient's condition. Both patients in the experimental and control groups had received HAART treatment.

[0053] Whole blood was collected from patients before and after treatment to perform a full panel of T lymphocyte subsets. The CD4+ T lymphocyte count results are shown in Table 1 below.

[0054] Table 1 Comparison of CD4+ T lymphocyte counts among different groups of patients Group Number of examples Before treatment 3 months after treatment Loratadine group 51 316.5±86.8 <![CDATA[386.5±94.6 ** ]]> Example 2 group 52 307.5±76.4 <![CDATA[443.3±113.8 * ]]> Comparative Example 1 46 323.6±60.7 <![CDATA[442.9±93.1 ** ]]> Comparative Example 2 45 301.1±71.1 <![CDATA[411.6±108.6 ** ]]> Comparative Example 3 Groups 50 319.7±78.6 <![CDATA[391.8±89.4 * ]]> Comparative Example 4 Groups 43 311.3±74.5 <![CDATA[354.1±96.2 * ]]> Compared with before treatment, * P < 0.05 ** P < 0.05.

[0055] As can be seen from Table 1 above, patients who took loratadine or the oral preparations prepared in Examples 2, 1, 2, and 3 showed a greater increase in CD4+ T lymphocytes before and after treatment, while patients in Comparative Example 4 who only used the topical gel showed a smaller increase in CD4+ T lymphocytes before and after treatment. This indicates that the oral preparations have a more significant effect on increasing CD4+ T lymphocytes in patients.

[0056] Based on the clinical efficacy observation indicators, the Dermatology Life Quality Index (DLQI) was adopted. The third volume of the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine" guides the clinical research of pruritus, the scoring criteria for pruritus, and the standards proposed at the 2010 National Conference on Integrated Traditional Chinese and Western Medicine in Dermatology and Venereology were used. The final reference standards are shown in Table 2 below. Among them, the area of ​​skin lesions was estimated according to the 9-zone method of burns, that is, the head, face and neck each accounted for 3%, both upper arms accounted for 7%, both forearms accounted for 6%, both hands accounted for 5%, the front and back of the trunk each accounted for 13%, both buttocks accounted for 9%, the perineum accounted for 1%, both thighs accounted for 21%, both lower legs accounted for 13%, and both feet accounted for 7%.

[0057] Table 2 Scoring Criteria for Clinical Symptom Grading symptom 0 points 1 point 2 points 3 points 4 points Itching none Mild itching, can be controlled by not scratching. Moderate itching, with no impact on daily life. Severe itching, but still tolerable Extreme itching, unbearable Frequency of itching 0 1-3 times / day 4-6 times / day 7-10 times / day >10 times / day Duration 0 1-2 min 3-5 min 6-10min >10min Area of ​​skin lesions none <25% of body surface area 26%-50% of body surface area 51%-75% of body surface area >76% of body surface area Sleep status normal Difficulty falling asleep, but able to fall asleep Difficulty falling asleep, waking up multiple times due to itching Difficulty falling asleep; waking up due to itching and being unable to fall back asleep. Unable to fall asleep Table 3 Clinical scores for pruritus Group Number of examples Before treatment One month after treatment 3 months after treatment Loratadine group 51 3.75±2.26 <![CDATA[3.23±1.85 * ]]> <![CDATA[2.84±2.68 ** ]]> Example 2 group 52 3.94±2.43 <![CDATA[2.96±1.25 * ]]> <![CDATA[1.94±0.81 ** ]]> Comparative Example 1 46 3.89±3.25 <![CDATA[3.47±1.46 ** ]]> <![CDATA[2.72±1.60 * ]]> Comparative Example 2 45 3.77±1.68 <![CDATA[3.18±1.18 * ]]> <![CDATA[2.33±1.84 * ]]> Comparative Example 3 Groups 50 3.96±2.17 <![CDATA[3.22±0.96 * ]]> <![CDATA[2.61±1.12 * <!-- 8 -->]]> Comparative Example 4 Groups 43 3.78±2.38 <![CDATA[3.06±1.37 ** ]]> <![CDATA[2.10±1.03 ** ]]> Compared with before treatment, *P<0.05, **P<0.01.

[0058] Table 4 Clinical score of itching frequency Group Number of examples Before treatment One month after treatment 3 months after treatment Loratadine group 51 3.91±1.68 <![CDATA[2.27±0.69 ** ]]> <![CDATA[1.61±0.57 * ]]> Example 2 group 52 3.97±1.37 <![CDATA[2.31±0.93 * ]]> <![CDATA[1.07±0.36 * ]]> Comparative Example 1 46 3.86±2.03 <![CDATA[3.08±0.45 ** ]]> <![CDATA[2.13±1.05 * ]]> Comparative Example 2 45 3.57±1.74 <![CDATA[2.75±0.68 * ]]> <![CDATA[1.92±1.33 ** ]]> Comparative Example 3 Groups 50 3.91±1.32 <![CDATA[2.82±1.03 * ]]> <![CDATA[2.09±0.98 * ]]> Comparative Example 4 Groups 43 3.79±2.08 <![CDATA[2.46±0.76 ** ]]> <![CDATA[1.31±0.63 ** ]]> Compared with before treatment, *P<0.05, **P<0.01.

[0059] Table 5 Clinical Scoring of Lesion Area Group Number of examples Before treatment One month after treatment 3 months after treatment Loratadine group 51 3.31±1.68 <![CDATA[2.73±0.70 * ]]> <![CDATA[1.93±0.38 ** ]]> Example 2 group 52 3.73±1.37 <![CDATA[2.84±0.86 ** ]]> <![CDATA[1.09±0.62 ** ]]> Comparative Example 1 46 3.21±2.03 <![CDATA[2.75±0.63 * ]]> <![CDATA[2.03±0.35 ** ]]> Comparative Example 2 45 3.62±1.74 <![CDATA[2.85±0.97 * ]]> <![CDATA[1.35±0.73 * ]]> Comparative Example 3 Groups 50 3.43±1.32 <![CDATA[2.88±0.68 ** ]]> <![CDATA[1.67±0.56 * ]]> Comparative Example 4 Groups 43 3.28±2.08 <![CDATA[2.69±1.03 * ]]> <![CDATA[1.21±0.82 ** ]]> Compared with before treatment, *P<0.05, **P<0.01.

[0060] Table 6 Comparison of Clinical Symptom Scores of Patients Group Number of examples Before treatment One month after treatment 3 months after treatment Loratadine group 51 17.42±3.57 <![CDATA[12.94±2.65 * ]]> <![CDATA[8.08±3.05 * ]]> Example 2 group 52 18.54±5.65 <![CDATA[11.82±5.81 ** ]]> <![CDATA[5.48±1.58 ** ]]> Comparative Example 1 46 16.46±4.85 <![CDATA[13.25±3.51 * ]]> <![CDATA[9.18±2.61 * ]]> Comparative Example 2 45 17.26±4.77 <![CDATA[13.01±4.67 ** ]]> <![CDATA[7.90±1.74 ** ]]> Comparative Example 3 Groups 50 17.35±5.75 <![CDATA[12.36±4.82 * ]]> <![CDATA[8.37±2.56 ** ]]> Comparative Example 4 Groups 43 17.29±2.65 <![CDATA[12.07±2.97 * ]]> <![CDATA[7.17±3.73 * ]]> Compared with before treatment, *P<0.05, **P<0.01.

[0061] The criteria were formulated based on the "Diagnosis and Efficacy Evaluation Standards for Common Diseases". Clinical cure: Complete disappearance of itching and basic regression of skin lesions. Significant effect: Significant reduction in itching and regression of skin lesions greater than or equal to 70%. Effective: Reduction in itching and regression of skin lesions greater than or equal to 30%. Ineffective: No significant improvement in itching and regression of skin lesions less than 30%. Significant effect rate = (Number of clinically cured cases + Number of cases with significant effect) / Total number of cases × 100%; Total effective rate = (Number of clinically cured cases + Number of cases with significant effect + Number of cases with effectiveness) / Total number of cases × 100%.

[0062] Table 7 Comparison of clinical efficacy among patients Group Number of examples cure Effective efficient invalid apparent efficiency Overall efficiency Loratadine group 51 5 10 23 15 29.4% 70.1% Example 2 group 52 13 18 16 5 <![CDATA[59.6% * ]]> <![CDATA[90.4% △ ]]> Comparative Example 1 46 7 13 14 12 <![CDATA[43.5% * ]]> <![CDATA[73.9% △ ]]> Comparative Example 2 45 9 14 11 11 <![CDATA[51.1% * ]]> 75.6% Comparative Example 3 Groups 50 9 16 16 9 50.0% <![CDATA[82.0% △ ]]> Comparative Example 4 Groups 43 3 13 12 15 <![CDATA[37.2% * ]]> 65.1% Compared with the loratadine group, the efficacy rate was significantly higher (P < 0.05) and the effective rate was lower (ΔP < 0.05).

[0063] The complete set of T lymphocytes in a patient before and after treatment with the oral and topical gels of this invention is shown in Table 8 below.

[0064] Table 8. Complete T lymphocyte count of a patient before and after one month of treatment. Inspection items Before treatment One month after treatment (Absolute value) T suppressor cells (CD3+CD8+) (CD8+) 837 cells / μL 1434 cells / μL (Absolute value) CD3+ T lymphocytes (CD3+) 1215 cells / μL 1843 cells / μL (Absolute value) T helper cells (CD3+CD4+) (CD4+) 313 cells / μL 373 cells / μL T helper cells (CD3+CD4+) 16% 13% T suppressor cells (CD3+CD8+) (T suppressor cells) 42% 51% T double-positive cells (CD3+CD4+CD8+) (T helper inhibition) 0 0 T / H (T helper / suppressor cell ratio) (T helper) 0.37 0.26 This invention can be implemented in various ways and is not limited to the embodiments described. Those skilled in the art will understand that the invention can be implemented in other specific ways without changing the technical concept or essential features. Therefore, it should be understood that the embodiments described above are exemplary and not intended to limit the invention.

Claims

1. A traditional Chinese medicine composition for improving skin itching associated with AIDS, characterized in that, The first and second compositions of the traditional Chinese medicine composition. The first composition includes: American ginseng, Bidens pilosa, Gynostemma pentaphyllum, Lithospermum erythrorhizon, centipede, scorpion, Smilax glabra, Hedyotis diffusa, cicada slough, Bombyx mori, wolfberry and Euonymus fortunei; The second composition includes: Euonymus fortunei, Schefflera heptaphylla, Gynostemma pentaphyllum, Lonicera japonica, Dictamnus dasycarpus, Kochia scoparia, Bidens pilosa, Lithospermum erythrorhizon, and Gardenia jasminoides.

2. The traditional Chinese medicine composition for improving skin itching in AIDS patients as described in claim 1, characterized in that, By weight, the first composition comprises: 10-20g American ginseng, 15-25g Bidens pilosa, 15-25g Gynostemma pentaphyllum, 10-20g Lithospermum erythrorhizon, several centipedes, 5-10g scorpion, 25-35g Smilax glabra, 25-35g Hedyotis diffusa, 5-10g cicada slough, 10-20g Bombyx mori, 15-25g wolfberry, and 10-20g Euonymus fortunei.

3. The traditional Chinese medicine composition for improving skin itching in AIDS patients as described in claim 2, characterized in that, By weight, the first composition mainly consists of 15g American ginseng, 20g Bidens pilosa, 20g Gynostemma pentaphyllum, 15g Lithospermum erythrorhizon, 1 centipede, 8g scorpion, 30g Smilax glabra, 30g Lysimachia christinae, 8g cicada slough, 15g Bombyx mori, 20g wolfberry and 15g Euonymus fortunei.

4. The traditional Chinese medicine composition for improving skin itching in AIDS patients as described in claim 1, characterized in that, The second composition, by weight, comprises: 10-20g of Euonymus fortunei, 25-35g of Schefflera heptaphylla, 25-35g of Gynostemma pentaphyllum, 10-20g of Lonicera japonica, 15-25g of Dictamnus dasycarpus, 25-35g of Kochia scoparia, 15-25g of Bidens pilosa, 10-20g of Lithospermum erythrorhizon, and 5-10g of Gardenia jasminoides.

5. The traditional Chinese medicine composition for improving skin itching in AIDS patients as described in claim 4, characterized in that, By weight, the second composition mainly consists of 15g of Euonymus fortunei, 30g of Schefflera heptaphylla, 30g of Gynostemma pentaphyllum, 15g of Lonicera japonica, 20g of Dictamnus dasycarpus, 30g of Kochia scoparia, 20g of Bidens pilosa, 15g of Lithospermum erythrorhizon and 8g of Gardenia jasminoides.

6. A method for preparing a traditional Chinese medicine composition for improving pruritus associated with AIDS as described in any one of claims 1-5, characterized in that, The preparation method comprises the following steps: S1. Take centipede and scorpion and stir-fry over low heat until crisp. After stir-frying, bring the centipede, scorpion and cicada molting to a boil over high heat and then simmer over low heat for 20-30 minutes. Add American ginseng, Smilax glabra, Gynostemma pentaphyllum, Euonymus fortunei, Bombyx batryticatus and water and bring to a boil over high heat. Then simmer over low heat for 10-15 minutes. Add Bidens pilosa, Lithospermum erythrorhizon, wolfberry and Hedyotis diffusa and simmer over low heat for 20-30 minutes. Filter and take the filtrate. Add water to the residue and simmer for 15-20 minutes. Filter and take the filtrate. Mix the two filtrates to obtain the first composition solution. S2, the second composition is pulverized into medicinal powder, the medicinal powder is extracted by percolation to obtain an extract, concentrated, centrifuged, filtered to obtain a concentrated extract, the concentrated extract is mixed with a gel matrix, phenoxyethanol and vitamin E are added and mixed, filtered to obtain a topical gel.

7. The method for preparing the traditional Chinese medicine composition for improving pruritus associated with AIDS as described in claim 6, characterized in that, In step S2, the second composition is pulverized into medicinal powder, which is then extracted using percolation to obtain an extract. The extract is concentrated, centrifuged, and filtered to obtain a concentrated extract. This concentrated extract is mixed with a gel matrix, and phenoxyethanol and vitamin E are added and mixed again. The mixture is then filtered to obtain a topical gel. The specific steps are as follows: S21. Take Kochia scoparia, Acer palmatum, Gynostemma pentaphyllum, Dictamnus dasycarpus, Bidens pilosa, Euonymus fortunei, Lithospermum erythrorhizon, Lonicera japonica, and Gardenia jasminoides. Grind them into 10-20 mesh powder. Soak the powder in a solvent. Fill the soaked powder into a percolation cylinder and soak for 2-3 hours. Adjust the flow rate to 1-3 mL / min and percolate to obtain an extract. Concentrate the extract and dilute it with purified water. Centrifuge and collect the supernatant. Filter the supernatant through a microporous membrane to obtain a concentrated extract. S22, prepare a gel matrix by taking carbomer, triglycerides and azone; S23, the extract concentrate is added to the gel matrix and mixed, then preservatives and vitamin E are added, and mixing continues. The mixture is then filtered through a microporous membrane to obtain a topical gel.

8. The method for preparing the traditional Chinese medicine composition for improving pruritus associated with AIDS as described in claim 8, characterized in that, The solvent is a 70%-80% aqueous ethanol solution.

9. The method for preparing the traditional Chinese medicine composition for improving pruritus associated with AIDS as described in claim 8, characterized in that, The concentration reaction conditions are a temperature of 50-55℃ and a vacuum of 0.06-0.08 MPa.

10. The method for preparing the traditional Chinese medicine composition for improving pruritus associated with AIDS as described in claim 8, characterized in that, The preservative is phenoxyethanol or methylparaben.

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