Bionic hybrid nano regulator for enhancing cell copper death as well as preparation method and application of bionic hybrid nano regulator

By designing a biomimetic hybrid nanomodulator, the problem of poor prognosis in colorectal cancer treatment was solved by utilizing tumor-targeted delivery and in-situ photothermal therapy. This achieved efficient recognition of tumor cells and enhanced sensitivity to copper death, activated anti-tumor immune responses, and inhibited tumor proliferation and recurrence.

CN120860248APending Publication Date: 2025-10-31INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Patent Information

Application Number
CN202511049576.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-29
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

In the treatment of colorectal cancer, traditional methods have poor prognoses, and tumor cells lose sensitivity to copper death, making it difficult to achieve effective copper death-immunotherapy.

Method used

A biomimetic hybrid nanoregulator is designed to achieve tumor-targeted delivery and in-situ photothermal therapy by coating the surface with hybrid macrophage membranes and tumor cell membranes, combined with lactate regulators and copper ion carriers, thereby enhancing the copper death sensitivity of tumor cells and activating anti-tumor immune responses.

Benefits of technology

It achieves efficient recognition and delivery of tumor cells, enhances copper death sensitivity, activates immune response, reverses the tumor immunosuppressive microenvironment, and inhibits tumor proliferation and recurrence.

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Abstract

The invention discloses a bionic hybrid nano regulator for enhancing cell copper death and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention designs a bionic nano-platform which simultaneously loads a lactic acid regulator cyclostilbene Su 3118 and a copper ion carrier disulfiram DSF, and the bionic nano-platform is combined with hybrid macrophages and tumor cell membranes to construct a nano-regulator SCTDM. The nano regulator can exert multiple functions, including tumor targeting, in-situ photothermal therapy, lactic acid regulation and enhanced copper death. The nano regulator provided by the invention is simple and convenient to manufacture, is combined with in-situ photothermal therapy and lactic acid regulation and is used for enhancing cell death immunotherapy of copper death so as to eliminate primary tumors and delay relapse, and a technical support is provided for regulating immunity by enhancing copper-induced cell death through metabolic reprogramming.
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