Total nutrient food with special medical purpose for children

Abstract

The invention belongs to the technical field of foods, and particularly relates to a full-nutrition food with special medical application for children. The full-nutrition food is prepared from the following components in parts by weight: 250 to 450 parts of fat powder (1), 40 to 100 parts of fat powder (2), 250 to 350 parts of maltodextrin, 150 to 250 parts of hydrolyzed whey protein, 2 to 6 parts of docosahexaenoic acid powder, 2 to 6 parts of arachidonic acid powder and the like. The full-nutrition food provided by the invention is mainly used for weak, long-term malnutrition, long-term bedridden patients, dietary bias and other children with insufficient long-term nutrient intake, and not only is easy to digest and better in intestinal adaptability, but also is comprehensive in nutrition and promotes growth and development.

Description

Technical Field

[0001] This invention belongs to the field of food technology, specifically relating to a complete nutritional food for children with special medical purposes. Background Technology

[0002] Malnutrition is a term used to describe a health condition caused by inappropriate or insufficient diet. It usually refers to nutritional deficiencies resulting from insufficient intake, poor absorption, or excessive loss of nutrients. However, it can also include nutritional excess caused by overeating or excessive intake of specific nutrients. If an individual cannot consistently consume a healthy diet consisting of appropriate quantities, types, or quality of nutrients, they will become malnourished. Long-term malnutrition can lead to starvation and death. Prolonged inadequate food intake is a major cause of malnutrition. The dangers of childhood malnutrition include: 1. In the early stages of malnutrition, height is not affected, but as the condition worsens, bone growth slows, and height falls below normal. Mild malnutrition may result in normal mental state, but severe malnutrition can cause lethargy, poor responsiveness, and fever. Symptoms include low blood pressure, weak and thready pulse, loss of appetite, alternating diarrhea and constipation, and a significant decrease in plasma albumin. Pitting edema and shiny skin may occur, and in severe cases, ulceration and infection may lead to chronic ulcers. Severe malnutrition can damage vital organ function; for example, decreased cardiac function may present with muffled heart sounds, low blood pressure, slowed pulse, and shallow breathing. 2. Due to weakened immune function, malnourished children are prone to various infections, such as recurrent respiratory infections, thrush, pneumonia, tuberculosis, otitis media, and urinary tract infections. Infant diarrhea often persists, exacerbating malnutrition and creating a vicious cycle. Malnutrition can also lead to spontaneous hypoglycemia, which may suddenly manifest as a pale complexion, altered mental status, slowed pulse, respiratory arrest, and no fever but no convulsions. Without timely treatment, this can be fatal.

[0003] Foods for Special Medical Purposes (FSMPs), also known as medical foods, are specially formulated foods designed to meet the specific nutritional or dietary needs of individuals with limited or restricted food intake, digestive and absorptive disorders, metabolic disturbances, or specific disease states. FSMPs are categorized into complete nutritional formulas, specific complete nutritional formulas, and incomplete nutritional formulas. Complete nutritional formulas, in particular, can serve as a single source of nutrition to meet the nutritional needs of the target population and have a wide range of applications.

[0004] Patent CN201610080706.2 discloses a protein powder and its preparation method for enhancing human immunity. The protein powder comprises the following components: soy protein isolate, whey protein, vitamin C, vitamin E, natural calcium carbonate, glucose, white sugar, dietary fiber, vegetable fat powder, dicalcium phosphate, steviol glycosides, silicon dioxide, and xylitol. The resulting product has a reasonable ratio, is rich in nutrients, is easily absorbed by the human body, and can enhance human immunity. However, the above invention has not undergone further efficacy testing, therefore its actual effect is unclear. Patent CN202011139241.6 discloses a method for preparing a nutritional formula powder to promote perioperative patient recovery. This nutritional formula powder includes concentrated whey protein, powdered oil, vegetable fat powder, maltodextrin, soy peptides, compound minerals, L-glutamine, resistant dextrin, silicon dioxide, compound vitamins, and sucralose. This nutritional powder formula is scientifically formulated and nutritionally balanced, designed to provide comprehensive nutrition for individuals under stress conditions such as trauma and infection, thereby enhancing immunity and postoperative healing throughout the surgical process. However, while the product disclosed in the aforementioned invention has undergone clinical trials related to wound healing and serum immunoglobulin levels, these trials only broadly demonstrate that the overall immunity of patients in the example group was significantly higher than that of the control and comparative groups throughout the perioperative period. However, these findings were not specifically expressed at the numerical level, thus the actual efficacy of the product remains unknown.

[0005] Given the lack of experimental research or data in existing technologies, as well as the unknown effects of related products on the immune system, it is crucial to find a composition that can effectively enhance human immunity and then apply it to foods for special medical purposes to more intuitively demonstrate the effects of the product. Summary of the Invention

[0006] The purpose of this invention is to provide a complete nutritional food for children with special medical purposes. The complete nutritional food for children with special medical purposes provided by this invention not only has a relatively small molecular weight and low osmotic pressure, resulting in better intestinal adaptability, but also provides comprehensive nutrition and promotes growth and development.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] This invention provides a complete nutritional food for children with special medical purposes, which, by weight, comprises the following components:

[0009] Fat powder ① 250-450 parts, maltodextrin 250-350 parts, hydrolyzed whey protein 150-250 parts, white sugar 50-100 parts, fat powder ② 40-100 parts, vitamin A acetate 0.005-0.02 parts, cholecalciferol 0.00005-0.0005 parts, dl-α-tocopherol acetate 0.02-0.2 parts, phytonabinone 0.0001-0.001 parts, thiamine hydrochloride 0.001-0.02 parts, riboflavin 0.001-0.01 parts, pyridoxine hydrochloride 0.005-0.02 parts, cyanocobalamin 0.00001-0.0001 parts, nicotinamide 0.01-0.1 parts, folic acid 0.0001-0.005 parts, D-calcium pantothenate 0.01-0.1 parts, sodium ascorbate 0.1-1 parts, biotin 0.0001-0.001 parts, inositol 0.1-1 parts, Taurine 0.1-1 parts, sodium citrate 1-2 parts, potassium citrate 2.5-4 parts, copper sulfate 0.001-0.05 parts, magnesium carbonate 2-5 parts, zinc gluconate 0.1-1 parts, ferric pyrophosphate 0.1-0.8 parts, manganese sulfate 0.001-0.01 parts, calcium carbonate 1-2 parts, calcium hydrogen phosphate 4-5 parts, potassium iodide 0.0001-0.001 parts, potassium chloride 3.5-5 parts, sodium selenite 0.0001-0.001 parts, choline chloride 0.7-1.5 parts, L-carnitine tartrate 0.2-0.5 parts, docosahexaenoic acid powder 2-6 parts, arachidonic acid powder 2-6 parts, vanillin 0.1-0.3 parts.

[0010] Preferably, the fat powder ① comprises the following components in parts by weight:

[0011] Maltodextrin 80-150 parts, compound vegetable oil 70-100 parts, sodium octenyl succinate starch 50-100 parts, medium-chain triglycerides 25-60 parts, dicalcium phosphate 5-15 parts, sodium ascorbate 0.1-1 part, ascorbate palmitate 0.1-0.5 parts, mixed tocopherol concentrate 0.01-0.1 parts.

[0012] More preferably, the compound vegetable oil comprises: 20-40 parts corn oil, 5-35 parts low erucic acid rapeseed oil, 5-20 parts high oleic acid sunflower seed oil, 5-20 parts coconut oil, and 5-15 parts soybean oil.

[0013] Preferably, the fat powder ② comprises the following components in parts by weight:

[0014] Medium-chain triglycerides 25-50 parts, maltodextrin 20-45 parts, sodium octenyl succinate starch 5-15 parts, mono- and diglycerides of fatty acids 0.1-1.0 parts.

[0015] Preferably, the osmotic pressure of the complete nutritional food is 360 mOsm / kg.

[0016] This invention also provides a method for preparing the above-mentioned complete nutritional food, comprising premixing vitamin A acetate, cholecalciferol, dl-α-tocopherol acetate, phytonabinone, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, nicotinamide, folic acid, D-calcium pantothenate, sodium ascorbate, biotin, inositol, taurine, sodium citrate, potassium citrate, copper sulfate, magnesium carbonate, zinc gluconate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium hydrogen phosphate, potassium iodide, potassium chloride, sodium selenite, choline chloride, L-carnitine tartrate, docosahexaenoic acid powder, arachidonic acid powder, vanillin and 35% maltodextrin, then mixing them together with 65% maltodextrin, fat powder ①, fat powder ②, hydrolyzed whey protein powder and white sugar, the entire mixing time being controlled at 30 minutes, the semi-finished product after mixing is subjected to metal detection to remove foreign matter, and then packaged with nitrogen.

[0017] This invention also provides the application of the above-mentioned complete nutritional food or the complete nutritional food prepared by the above-mentioned preparation method in promoting children's growth and development.

[0018] The beneficial effects of this invention are:

[0019] This product is primarily designed for children who are weak, suffer from chronic malnutrition, are bedridden for extended periods, or have unbalanced diets or other long-term nutrient deficiencies. It contains 100% hydrolyzed whey protein, an easily digestible and absorbable hydrolyzed formula. Compared to extensively hydrolyzed whey protein with a smaller molecular weight, it has a lower osmotic pressure, better intestinal adaptability, and provides comprehensive nutrition to promote growth and development. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 The molecular weight distribution of the complete nutritional food for special medical purposes for children prepared in Example 1 is shown in the figure.

[0022] Figure 2 The image shows the physicochemical test results of the complete nutritional food for special medical purposes for children prepared in Example 1.

[0023] Figure 3 The graph shows the changes in body weight of the two groups of rats during each cycle. Detailed Implementation

[0024] To further illustrate the present invention, the technical solutions provided by the present invention will be described in detail below with reference to the accompanying drawings and embodiments, but these should not be construed as limiting the scope of protection of the present invention.

[0025] Unless otherwise specified, the production processes, experimental methods, or testing methods involved in the embodiments of this invention are all conventional methods in the prior art, and their names and / or abbreviations are all conventional names in the field, which are very clear and distinct in the relevant application areas. Those skilled in the art can understand the conventional process steps based on the names and apply the corresponding equipment, and implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0026] The various instruments, equipment, raw materials or reagents used in the embodiments of this invention are not subject to any special restrictions on their source. They are all conventional products that can be purchased through regular commercial channels and can be prepared according to conventional methods known to those skilled in the art.

[0027] Example 1

[0028] 1.1 This example provides a complete nutritional food for children with special medical purposes, which, by weight, comprises the following components:

[0029] Fat powder ① 324 parts, maltodextrin 321 parts, hydrolyzed whey protein 186 parts, white sugar 76 parts, fat powder ② 63 parts, vitamin A acetate 0.008 parts, cholecalciferol 0.0001 parts, dl-α-tocopherol acetate 0.05 parts, phytonabinone 0.0003 parts, thiamine hydrochloride 0.01 parts, riboflavin 0.008 parts, pyridoxine hydrochloride 0.01 parts, cyanocobalamin 0.00002 parts, nicotinamide 0.04 parts, folic acid 0.0015 parts, D-calcium pantothenate 0.03 parts, sodium ascorbate 0.5 parts, biotin 0.0002 parts, inositol 0.5 parts, taurine 0.5 parts, sodium citrate 1.534 parts, potassium citrate 3 parts, copper sulfate 0.01 parts, magnesium carbonate 3.5 parts, zinc gluconate 0.35 parts, ferric pyrophosphate 0.29 parts, manganese sulfate 0.007 parts, calcium carbonate 1.85 parts, calcium hydrogen phosphate 4.75 parts, potassium iodide 0.0002 parts, potassium chloride 3.5 parts, sodium selenite 0.0002 parts, choline chloride 1.15 parts, L-carnitine tartrate 0.3 parts, docosahexaenoic acid powder 4 parts, arachidonic acid powder 4 parts, vanillin 0.1 parts.

[0030] The fat powder ① includes 120 parts of maltodextrin, 79 parts of compound vegetable oil (30 parts of corn oil, 19 parts of low erucic acid rapeseed oil, 10.5 parts of high oleic acid sunflower oil, 10.5 parts of coconut oil, and 9 parts of soybean oil), 74 parts of octenyl succinate starch, 42 parts of medium-chain triglycerides, 8.2 parts of dicalcium phosphate, 0.6 parts of sodium ascorbate, 0.12 parts of ascorbate palmitate, and 0.08 parts of mixed tocopherol concentrate; the fat powder ② includes 31 parts of medium-chain triglycerides, 25 parts of oligomaltose, 6.5 parts of sodium octenyl succinate starch, and 0.5 parts of mono- and diglycerides of fatty acids.

[0031] 1.2 Preparation process

[0032] Vitamin A acetate, cholecalciferol, dl-α-tocopherol acetate, phytonabinone, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, nicotinamide, folic acid, D-calcium pantothenate, sodium ascorbate, biotin, inositol, taurine, sodium citrate, potassium citrate, copper sulfate, magnesium carbonate, zinc gluconate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium hydrogen phosphate, potassium iodide, potassium chloride, sodium selenite, choline chloride, L-carnitine tartrate, docosahexaenoic acid powder, arachidonic acid powder, vanillin, and 35% maltodextrin were premixed. Then, they were mixed with 65% maltodextrin, fat powder ①, fat powder ②, hydrolyzed whey protein powder, and white sugar. The total mixing time was controlled at 30 minutes. The semi-finished product after mixing was subjected to metal detection to remove foreign matter, and then nitrogen-filled packaging was performed.

[0033] Example 2

[0034] 2.1 This example provides a complete nutritional food for children with special medical purposes, which, by weight, comprises the following components:

[0035] Fat powder ① 350 parts, maltodextrin 310 parts, hydrolyzed whey protein 203 parts, white sugar 55 parts, fat powder ② 50 parts, vitamin A acetate 0.009 parts, cholecalciferol 0.0002 parts, dl-α-tocopherol acetate 0.06 parts, phytonabinone 0.0004 parts, thiamine hydrochloride 0.02 parts, riboflavin 0.009 parts, pyridoxine hydrochloride 0.02 parts, cyanocobalamin 0.00003 parts, nicotinamide 0.05 parts, folic acid 0.0018 parts, D-calcium pantothenate 0.035 parts, sodium ascorbate 0.6 parts, biotin 0. 0.0003 parts, inositol 0.4 parts, taurine 0.4 parts, sodium citrate 2.405 parts, potassium citrate 3.5 parts, copper sulfate 0.02 parts, magnesium carbonate 3.4 parts, zinc gluconate 0.31 parts, ferric pyrophosphate 0.35 parts, manganese sulfate 0.008 parts, calcium carbonate 1.9 parts, calcium hydrogen phosphate 5 parts, potassium iodide 0.0004 parts, potassium chloride 4 parts, sodium selenite 0.0004 parts, choline chloride 1.2 parts, L-carnitine tartrate 0.4 parts, docosahexaenoic acid powder 3.8 parts, arachidonic acid powder 3.8 parts, vanillin 0.3 parts;

[0036] Among them, fat powder ① includes 130 parts of maltodextrin, 82 parts of compound vegetable oil (30 parts of corn oil, 20 parts of low erucic acid rapeseed oil, 11 parts of high oleic acid sunflower seed oil, 11 parts of coconut oil, and 10 parts of soybean oil), 77 parts of octenyl succinic acid starch, 52 parts of medium-chain triglycerides, 8.2 parts of dicalcium phosphate, 0.6 parts of sodium ascorbate, 0.12 parts of ascorbate palmitate, and 0.08 parts of mixed tocopherol concentrate; fat powder ② includes 25 parts of medium-chain triglycerides, 20 parts of oligomaltose, 4.5 parts of sodium octenyl succinic acid starch, and 0.5 parts of mono- and diglyceride fatty acid esters.

[0037] 2.2 Preparation process

[0038] Vitamin A acetate, cholecalciferol, dl-α-tocopherol acetate, phytonabinone, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, nicotinamide, folic acid, D-calcium pantothenate, sodium ascorbate, biotin, inositol, taurine, sodium citrate, potassium citrate, copper sulfate, magnesium carbonate, zinc gluconate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium hydrogen phosphate, potassium iodide, potassium chloride, sodium selenite, choline chloride, L-carnitine tartrate, docosahexaenoic acid powder, arachidonic acid powder, vanillin, and 35% maltodextrin were premixed. Then, they were mixed with 65% maltodextrin, fat powder ①, fat powder ②, hydrolyzed whey protein powder, and white sugar. The total mixing time was controlled at 30 minutes. The semi-finished product after mixing was subjected to metal detection to remove foreign matter, and then nitrogen-filled packaging was performed.

[0039] Example 3: Determination of molecular weight of hydrolyzed whey protein in complete nutritional foods

[0040] The molecular weight of hydrolyzed whey protein in a complete nutritional food for special medical purposes for children was determined by high performance liquid chromatography.

[0041] Sample preparation: The product was dissolved in the HPLC mobile phase (36% acetonitrile aqueous solution containing 0.1% trifluoroacetic acid (TFA)) at a concentration of 0.1% (w / v). The dissolved sample was filtered through a 0.2 μm low protein binding syringe filter and then analyzed by HPLC.

[0042] Preparation of standards: Molecular weight standards were prepared in the same mobile phase at a concentration of 50 to 100 μg / mL.

[0043] The HPLC analysis conditions are as follows:

[0044] Chromatographic column: TSK-GEL G2000SWXL (30cm x 7.8mm, 5μm).

[0045] Mobile phase: 36% acetonitrile aqueous solution containing 0.1% TFA.

[0046] Flow rate: 1.0 mL / min.

[0047] Injection volume: 10 μL.

[0048] Detector: UV detector, wavelength 205nm.

[0049] Results are expressed as area percentage (Area%).

[0050] Molecular weight calibration: Calibration curves were established using a series of peptide and protein standards with known molecular weights. The linear relationship between the logarithm of molecular weight and retention time was determined by analyzing these standards.

[0051] Chromatogram partitioning and result calculation: Using the calibration relationship described above, the retention time axis of the chromatogram is converted into a molecular weight scale. Based on this scale, the precise retention time points corresponding to molecular weights of 20,000, 10,000, 5,000, 2,000, 1,000, and 500 are determined. Using these time points, the chromatogram is divided into the following molecular weight ranges: 20,000, 20,000–10,000, 10,000–5,000, 5,000–2,000, 2,000–1,000, 1,000–500, and <500.

[0052] Molecular weight test results as follows Figure 1 and Figure 2 As shown.

[0053] Figure 1 The results showed that 40.5% of the hydrolyzed whey protein was distributed in the <1000 range, indicating that the proportion of low molecular weight components in the sample was relatively high, which means that there were more small molecular weight substances or degradation products in the sample.

[0054] Generally speaking, substances with a molecular weight between 5,000 and 10,000 are called macropeptides; substances with a molecular weight between 180 and 5,000 are called peptides; and substances with a molecular weight between 1,000 and 180 are called small peptides, also known as small molecule bioactive peptides. Based on... Figure 2 Molecular weight analysis revealed that hydrolyzed whey protein comprises approximately 60% peptides, with 6.66% being macropeptides and 38% being small peptides. Small peptides can be directly absorbed via intestinal transporters without digestion, exhibiting relatively high bioavailability. Peptides of different molecular weights provide diverse biological activities, forming a synergistic network. This combination of rapid onset and long-term regulatory effects makes it particularly suitable for nutritional interventions with high absorption requirements.

[0055] Example 4: In vitro simulated protein digestion experiment

[0056] 4.1 Materials and Reagents

[0057] Peptide formulation (product prepared in Example 1); Whole protein formulation (hydrolyzed whey protein in the product prepared in Example 1 is replaced with whey protein concentrate). Pepsin, trypsin (Sigma-Aldrich). Hydrochloric acid, sodium hydroxide, trichloroacetic acid, potassium chloride, potassium dihydrogen phosphate, sodium hydrogen phosphate, sodium chloride, magnesium chloride hexahydrate, ammonium carbonate.

[0058] 4.2 Instruments and Equipment

[0059] High-speed refrigerated centrifuge (Shanghai Anting Scientific Instrument Factory); electric thermostatic water bath (Shanghai Yiheng Scientific Instrument Co., Ltd.); water bath thermostatic shaker (Tianjin Sederlis Experimental Analytical Instrument Manufacturing Factory).

[0060] 4.3 Methods: The improved INFOGEST standard static in vitro digestion model test method was used.

[0061] The concentrations of gastric mimicry solution (SGF) and intestinal mimicry solution (SIF) are shown in Table 1. Gastrointestinal mimicry solutions can be prepared in advance for use before the experiment.

[0062] Table 1. Gastric and Intestinal Simulation Fluid

[0063]

[0064] Note: CaCl2(H2O)2 should be prepared as a 0.3 mol / L solution and added before use.

[0065] 4.4 Experimental Procedure

[0066] (1) Simulating the gastric digestion stage

[0067] Prepare a sample with a protein content of 4% in an Erlenmeyer flask. Add the sample solution to SGF, adjust the pH to 3.0 with hydrochloric acid solution, add CaCl2(H2O)2 solution, and add pepsin solution to make the pepsin activity in the final digestion solution reach 2000 U / m. Then add water to make up the volume so that the volume ratio of sample solution to SGF is 1:1. Place the sample in a constant temperature water bath at 37℃ and take samples at 0, 5, 10, 30, 60 and 120 min respectively. Adjust the pH to 7.0 to inactivate the enzyme.

[0068] (2) Simulated intestinal digestion stage

[0069] After 120 min of simulated gastric digestion, the pH was adjusted to 7.0 with NaOH solution to inactivate the enzyme. Then, intestinal digestive fluid SIF was added, followed by CaCl2(H2O)2 solution and trypsin solution to bring the trypsin activity in the final digestive fluid to 100 U / mL. Water was then added to bring the volume to a 1:1 ratio between the sample solution and SIF. The sample was placed in a constant temperature water bath at 37°C, and samples were taken at 60 and 120 min of reaction time, followed by 5 min of boiling water bath to inactivate the enzyme.

[0070] (3) Sample processing after digestion

[0071] After the sample was removed, an equal volume of 24% trichloroacetic acid (TCA) solution was added to precipitate it. The sample was then centrifuged at 9000 r / min for 20 min, and the supernatant was taken to detect the protein content.

[0072] The protein digestibility is calculated as follows:

[0073]

[0074] In the formula: M0 is the total protein content in the blank control supernatant, g; M1 is the total protein content in the sample supernatant, g; M2 is the total protein content in the sample, g.

[0075] (4) Experimental Results

[0076] Table 2 Results of gastrointestinal digestion experiments

[0077] Digestion time Whole protein formula Partially hydrolyzed formulation Initial digestion (0 min) 2.6 40.0 Digestion in the stomach is complete (120 minutes) 40.3 69.5 Intestinal digestion complete (240 min) 73.4 89.5

[0078] Experimental results showed that, in the initial digestion stage, the gastric digestion stage, and the final intestinal digestion stage, the digestibility of peptide formulations derived from hydrolyzed whey protein was significantly higher than that of whole protein formulations. Peptide formulations derived from hydrolyzed whey protein have undergone pre-digestion, making them easier to digest in the gastrointestinal tract and facilitating gastric emptying. This makes them more suitable for individuals with digestive and absorptive disorders, improving intestinal tolerance to nutrition and thus enhancing nutritional status.

[0079] Example 5 Osmotic Pressure Measurement

[0080] Method: Prepare three solutions of equal concentration (1 ml / 1 kcal) (product A, extensively hydrolyzed product B, and regular whey protein product C), and determine the osmotic pressure using freezing point osmometry.

[0081] Table 3 Osmotic Pressure Results

[0082]

[0083]

[0084] Hydrolysis breaks down large protein molecules into smaller peptides or amino acids. The higher the number of solute particles (ions / molecules) in a solution, the higher the osmotic pressure. Extensive hydrolysis produces a large number of small molecules, significantly increasing the particle number. High osmotic pressure may cause water reabsorption from the intestines, leading to a sudden increase in intestinal lumen volume and accelerated peristalsis, resulting in osmotic diarrhea, especially in individuals with sensitive gastrointestinal tracts where the intestinal tolerance threshold is significantly reduced.

[0085] Example 6 Animal Experiment

[0086] 6.1 Experimental Design:

[0087] Thirty male SD rats, 3 weeks old, with an average weight of 52.1g, were randomly divided into two groups (control group and experimental group), with 15 rats in each group. The experimental group was fed the product prepared according to the example, while the control group was fed a commercially available whole protein formula. All rats were fed individually in stainless steel cages. Feed was provided at the same time each day, with free access to food and water. The amount of food consumed was recorded, and the rats were weighed every 6 days. The feeding period lasted for 30 days.

[0088] 6.2 Test Results:

[0089] Table 4. Food intake (g) per cycle for the two groups of rats.

[0090] Group n Week 1 Week 2 Week 3 Week 4 Week 5 control group 15 37.5±4.2 48.5±4.9 46.6±5.6 55.6±8.9 60.3±7.0 experimental group 15 38.0±7.1 47.0±8.5 54.0±8.5 61.7±10.8 63.5±8.2

[0091] Table 5. Weight gain (g) of rats in both groups per cycle.

[0092]

[0093] The experimental results showed that the weight of rats in both groups increased as the experimental time increased. Starting from the second cycle, the weight of rats in the experimental group gradually increased compared to the control group. The weight gain of rats in the experimental group was significantly higher than that in the third and fourth cycles than that in the control group.

[0094] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A complete nutritional food for children with special medical purposes, characterized in that, The complete nutritional food comprises the following components by weight: Fat powder ① 250-450 parts, maltodextrin 250-350 parts, hydrolyzed whey protein 150-250 parts, white sugar 50-100 parts, fat powder ② 40-100 parts, vitamin A acetate 0.005-0.02 parts, cholecalciferol 0.00005-0.0005 parts, dl-α-tocopherol acetate 0.02-0.2 parts, phytonabinone 0.0001-0.001 parts, thiamine hydrochloride 0.001-0.02 parts, riboflavin 0.001-0.01 parts, pyridoxine hydrochloride 0.005-0.02 parts, cyanocobalamin 0.00001-0.0001 parts, nicotinamide 0.01-0.1 parts, folic acid 0.0001-0.005 parts, D-calcium pantothenate 0.01-0.1 parts, sodium ascorbate 0.1-1 parts, biotin 0.0001-0.001 parts, inositol 0.1-1 parts, Taurine 0.1-1 parts, sodium citrate 1-2 parts, potassium citrate 2.5-4 parts, copper sulfate 0.001-0.05 parts, magnesium carbonate 2-5 parts, zinc gluconate 0.1-1 parts, ferric pyrophosphate 0.1-0.8 parts, manganese sulfate 0.001-0.01 parts, calcium carbonate 1-2 parts, calcium hydrogen phosphate 4-5 parts, potassium iodide 0.0001-0.001 parts, potassium chloride 3.5-5 parts, sodium selenite 0.0001-0.001 parts, choline chloride 0.7-1.5 parts, L-carnitine tartrate 0.2-0.5 parts, docosahexaenoic acid powder 2-6 parts, arachidonic acid powder 2-6 parts, vanillin 0.1-0.3 parts.

2. The complete nutritional food according to claim 1, characterized in that, By weight, the fat powder ① comprises the following components: Maltodextrin 80-150 parts, compound vegetable oil 70-100 parts, sodium octenyl succinate starch 50-100 parts, medium-chain triglycerides 25-60 parts, dicalcium phosphate 5-15 parts, sodium ascorbate 0.1-1 part, ascorbate palmitate 0.1-0.5 parts, mixed tocopherol concentrate 0.01-0.1 parts.

3. The complete nutritional food according to claim 2, characterized in that, The compound vegetable oil comprises: 20-40 parts corn oil, 5-35 parts low erucic acid rapeseed oil, 5-20 parts high oleic acid sunflower seed oil, 5-20 parts coconut oil, and 5-15 parts soybean oil.

4. The complete nutritional food according to claim 1, characterized in that, The fat powder ② comprises the following components in parts by weight: Medium-chain triglycerides 25-50 parts, maltodextrin 20-45 parts, sodium octenyl succinate starch 5-15 parts, mono- and diglycerides of fatty acids 0.1-1.0 parts.

5. The complete nutritional food according to any one of claims 1-4, characterized in that, The osmotic pressure of the complete nutritional food is 360 mOsm / kg.

6. A method for preparing the complete nutritional food according to any one of claims 1-5, characterized in that, The process involves premixing vitamin A acetate, cholecalciferol, dl-α-tocopherol acetate, phytonabinone, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, nicotinamide, folic acid, D-calcium pantothenate, sodium ascorbate, biotin, inositol, taurine, sodium citrate, potassium citrate, copper sulfate, magnesium carbonate, zinc gluconate, ferric pyrophosphate, manganese sulfate, calcium carbonate, calcium hydrogen phosphate, potassium iodide, potassium chloride, sodium selenite, choline chloride, L-carnitine tartrate, docosahexaenoic acid powder, arachidonic acid powder, vanillin, and 35% maltodextrin. This mixture is then fully mixed with 65% maltodextrin, fat powder ①, fat powder ②, hydrolyzed whey protein powder, and white sugar. The entire mixing time is controlled to 30 minutes. The semi-finished product after mixing undergoes metal detection to remove foreign matter, and then is packaged with nitrogen.

7. The use of the complete nutritional food according to any one of claims 1-5 or the complete nutritional food prepared by the preparation method according to claim 6 in promoting children's growth and development.

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