Neutral peritoneal dialysis bag and preparation method thereof

Abstract

The invention relates to the technical field of medicine packaging, and particularly discloses a neutral peritoneal dialysis bag and a preparation method thereof. According to the neutral peritoneal dialysis bag provided by the invention, the solution bag is detachably coated with the outer packaging bag, and the outer packaging bag is added with polyethylene glycol grafted nano carbon nitride and acetylene black, so that the outer packaging bag has excellent photothermal conversion performance and can provide lasting and stable heat support for the dialysis bag; therefore, the problem of solute precipitation of the neutral peritoneal dialysis solution caused by the temperature lower than 15 DEG C during transportation and storage is effectively prevented, the dialysis solution is kept in a uniform state, and the concentration stability of effective components is ensured. Besides, the raw materials of the outer packaging bag in the neutral peritoneal dialysis bag provided by the invention are common materials, the cost is low, and the large-scale production can be realized by matching with a simple preparation process.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical packaging, and particularly discloses a neutral peritoneal dialysis bag and a preparation method thereof. BACKGROUND

[0002] In peritoneal dialysis treatment, the storage and transportation conditions of the neutral peritoneal dialysis solution directly relate to its treatment effect and use safety, and the temperature factor is particularly critical. At present, in the environment below 15℃, the solutes in the dialysis solution will be precipitated due to the decrease of solubility in the traditional peritoneal dialysis bag. If the temperature is reduced to below 10℃, the degree of precipitation of the solutes in the dialysis solution will be significantly increased, and then crystallization or precipitation will be generated. The solutes precipitated at low temperature will destroy the uniformity of the drug solution, cause the concentration of the effective components in the dialysis solution to deviate from the preset standard, and directly affect the treatment effect, so that the expected dialysis clearance efficiency cannot be achieved. It may cause the metabolic waste and excess water in the body to be unable to be fully discharged, and then the patient's condition is aggravated. At the same time, the precipitated solutes may block the peritoneal dialysis catheter, cause the dialysis passage to be obstructed, and then cause the catheter to be blocked and the dialysis to be interrupted. In addition, the precipitated solutes will cause strong stimulation to the peritoneum of the patient, cause the patient to have obvious discomfort, and then increase the probability of occurrence of related complications.

[0003] In order to solve the problems caused by low temperature, external devices such as water bath and electric heating are often needed in clinical operation to preheat the dialysis solution. However, this way is complicated in operation process and it is difficult to accurately control the temperature, and the situation of over-heating or under-heating is prone to occur, which further increases the complexity and potential risk of medical operation, and it is difficult to meet the clinical demand for convenient and safe use of dialysis solution. Based on this, how to solve the problem of precipitation of dialysis solution solutes by using a neutral peritoneal dialysis solution bag has important practical significance in the field of medical packaging. SUMMARY

[0004] In view of the problem that the peritoneal dialysis solution in the prior art will cause the solutes to precipitate due to low temperature, the present application provides a neutral peritoneal dialysis bag and a preparation method thereof. The neutral peritoneal dialysis bag comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably covered outside the solution bag, and the outer packaging bag combines polyethylene glycol grafted carbon nitride nanomaterials with acetylene black, so that the outer packaging bag has good light-heat conversion efficiency. During transportation and storage, only light is needed to maintain the temperature of the neutral peritoneal dialysis solution. In addition, the addition of acetylene black significantly improves the light absorption performance of the dialysis bag, effectively prevents the possible adverse effects of light on the neutral peritoneal dialysis solution, and effectively solves the problem that the neutral peritoneal dialysis solution in the prior art will precipitate solutes due to low temperature.

[0005] In order to achieve the above-mentioned application purposes, the present application provides the following technical solutions:

[0006] The application provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably wrapped outside the solution bag, and the outer packaging bag is prepared from the following components in parts by mass:

[0007] 3-10 parts of polypropylene resin, 20-30 parts of polyethylene glycol, 3-7 parts of reinforcing agent, 0.5-1 part of lubricant, 0.5-1 part of coupling agent, 24-35 parts of adhesive, 5-10 parts of polyethylene glycol grafted nanometer carbon nitride and 1-5 parts of acetylene black.

[0008] The outer packaging bag is detachably wrapped outside the solution bag, and the addition of polyethylene glycol grafted nanometer carbon nitride and acetylene black in the outer packaging bag makes the outer packaging bag have better light-heat conversion efficiency. The infrared absorption wavelength of the polyethylene glycol grafted nanometer carbon nitride is 700-2500 nm, the polyethylene glycol grafted nanometer carbon nitride can efficiently absorb infrared rays in the environment and convert the infrared rays into heat energy, thereby providing continuous and stable heat supply for the dialysis bag. When the environmental temperature is lower than 15 DEG C, the problem of solute precipitation in the neutral peritoneal dialysis solution due to low temperature can be avoided during transportation and storage, the dialysis solution can be ensured to be in a uniform state, the stability of the effective ingredient concentration can be maintained, and the problem of solute precipitation in the neutral peritoneal dialysis solution due to low temperature can be further avoided under the assistance of acetylene black.

[0009] Meanwhile, the polypropylene resin provides good structural support for the outer packaging bag; the polyethylene glycol improves the flexibility of different raw materials; the reinforcing agent enhances the mechanical properties of the outer packaging bag, so that the wear resistance and impact resistance of the outer packaging bag during transportation, storage and use are improved; the lubricant enables the raw materials to be better mixed and formed during processing, thereby ensuring the uniformity of the quality of the outer packaging bag; and the coupling agent promotes the combination between different raw materials and improves the overall stability of the material.

[0010] In addition, the outer packaging bag of the neutral peritoneal dialysis bag is detachably wrapped outside the solution bag, when the environmental temperature is high, the outer packaging bag can be detached, and the problem of excessively high solution temperature caused by heat absorption of the outer packaging bag can be avoided.

[0011] Preferably, the preparation method of the polyethylene glycol grafted nanometer carbon nitride comprises the following steps:

[0012] S1, mixing nanometer carbon nitride, mixed acid solution and hydrogen peroxide solution, performing hydroxylation reaction at 50 DEG C-70 DEG C, and then performing solid-liquid separation to obtain hydroxylated nanometer carbon nitride;

[0013] S2, mixing the hydroxylated nanometer carbon nitride, N,N-dimethylformamide, polyethylene glycol diglycidyl ether and triethylamine, carrying out grafting reaction at 70-90 DEG C, and then solid-liquid separation to obtain the polyethylene glycol grafted nanometer carbon nitride.

[0014] The application provides a preparation method of polyethylene glycol grafted nanometer carbon nitride, realizes polyethylene glycol modification of nanometer carbon nitride, effectively improves the dispersion performance of nanometer carbon nitride, makes the modified nanometer carbon nitride uniformly mixed with each material of the outer packaging bag of the neutral peritoneal dialysis bag, and solves the problem of easy agglomeration of nanometer carbon nitride. Meanwhile, the modification process does not damage the basic structure of nanometer carbon nitride, so that the nanometer carbon nitride retains the light-heat conversion capability and can stably realize energy conversion under light.

[0015] Preferably, in S1, the use amount ratio of the nanometer carbon nitride, the mixed acid solution and the hydrogen peroxide solution is 1g:(80-120)mL:(2-7)mL, the mixed acid solution is a mixed solution of a nitric acid solution and a sulfuric acid solution, the mass fraction concentration of the nitric acid solution is 40%-60%, the mass fraction concentration of the sulfuric acid solution is 40%-60%, the volume ratio of the nitric acid solution to the sulfuric acid solution is 1:2-4, and the mass fraction concentration of the hydrogen peroxide solution is 20%-40%.

[0016] Preferably, in S1, the hydroxylation reaction time is 3h-5h.

[0017] Further preferably, in S1, the particle size of the nanometer carbon nitride is 50nm-100nm.

[0018] Preferably, in S2, the use amount ratio of the hydroxylated nanometer carbon nitride, N,N-dimethylformamide, polyethylene glycol diglycidyl ether and triethylamine is 1g:(40-60)mL:(0.4-0.6)g:(0.05-0.15)mL.

[0019] Further preferably, in S2, the number average molecular weight of the polyethylene glycol diglycidyl ether is 400-600.

[0020] Preferably, in S2, the grafting reaction time is 18h-30h.

[0021] Further preferably, in S2, the grafting reaction is carried out in a protective atmosphere, and the protective atmosphere is a nitrogen atmosphere or an argon atmosphere.

[0022] Further preferably, in S2, the grafting reaction is carried out under stirring, and the stirring speed is 400rpm-600rpm.

[0023] Preferably, the reinforcing agent is selected from calcium carbonate, talc, kaolin, glass fiber, nanometer silicon dioxide or nanometer clay.

[0024] The application enhances the mechanical property of the outer packaging bag in the neutral peritoneal dialysis bag by limiting the type of reinforcing agent, reduces the risk of damage, and prolongs the service life.

[0025] Preferably, the lubricant is selected from stearic acid, calcium stearate, zinc stearate or paraffin.

[0026] The application improves the smoothness of mixing and processing of each raw material by limiting the type of lubricant, and ensures the uniform quality of the outer packaging bag in the neutral peritoneal dialysis bag.

[0027] Preferably, the coupling agent is selected from silane coupling agent or titanate coupling agent.

[0028] The application enhances the binding force of each raw material of the outer packaging bag in the neutral peritoneal dialysis bag by limiting the type of coupling agent, improves the uniformity and stability of the material, and reduces the performance defects caused by component separation.

[0029] Preferably, the adhesive is selected from thermoplastic polyurethane or water-based polyurethane adhesive.

[0030] The application enhances the binding strength of each raw material of the outer packaging bag in the neutral peritoneal dialysis bag by limiting the type of adhesive, improves the sealing property and structural stability of the outer packaging bag in the neutral peritoneal dialysis bag.

[0031] Preferably, the preparation method of the packaging bag comprises the following steps:

[0032] The polypropylene resin, polyethylene glycol, reinforcing agent, lubricant, coupling agent, adhesive, polyethylene glycol grafted nanometer carbon nitride and acetylene black are mixed, and then melt extrusion and rolling are sequentially performed to obtain the outer packaging bag.

[0033] Further preferably, the mixing time is 10-15 min, and the temperature is 25℃-35℃.

[0034] Further preferably, the temperature of each zone of melt extrusion is: zone one 150℃-160℃, zone two 165℃-170℃, zone three 170℃-175℃, and zone four 170℃-175℃.

[0035] In summary, the outer packaging bag in the neutral peritoneal dialysis bag provided by the application has excellent light-heat conversion performance by adding polyethylene glycol grafted nanometer carbon nitride and acetylene black, can provide persistent and stable heat support for the dialysis bag, thereby effectively preventing the precipitation of neutral peritoneal dialysis solution solute caused by temperature lower than 15℃ during transportation and storage, ensuring the dialysis solution to maintain a uniform state and ensuring the stability of the effective ingredient concentration.

[0036] In addition, the outer packaging bag of the neutral peritoneal dialysis bag is made of common materials, has low cost, and is simple to prepare, which is helpful to realize large-scale production. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present application, but not all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0038] Embodiment 1

[0039] The embodiment provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably covered outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fraction:

[0040] 3 parts of polypropylene resin, 20 parts of polyethylene glycol, 3 parts of calcium carbonate, 0.5 parts of paraffin, 0.5 parts of titanate coupling agent, 24 parts of water-based polyurethane adhesive, 5 parts of polyethylene glycol grafted nanocarbon nitride and 1 part of acetylene black.

[0041] The preparation method of the polyethylene glycol grafted nanocarbon nitride comprises the following steps:

[0042] S1, 1g of nanocarbon nitride powder, 80mL of mixed acid solution and 2mL of 20% hydrogen peroxide solution are mixed, heated at 50℃ for 3 hours, then filtered with a 0.22μm filter membrane to obtain hydroxylated nanocarbon nitride, wherein the mixed acid solution is a mixed solution of nitric acid solution and sulfuric acid solution, the mass fraction concentration of the nitric acid solution is 40%, the mass fraction concentration of the sulfuric acid solution is 40%, and the volume ratio of the nitric acid solution to the sulfuric acid solution is 1:2.

[0043] S2, 1g of hydroxylated nanocarbon nitride, 40mL of N,N-dimethylformamide, 0.4g of polyethylene glycol diglycidyl ether and 0.05mL of triethylamine are mixed, heated at 400rpm, 70℃ and under nitrogen protection for 18h, and the precipitate is collected by centrifugation to obtain polyethylene glycol grafted nanocarbon nitride.

[0044] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0045] The polypropylene resin, polyethylene glycol, calcium carbonate, paraffin, titanate coupling agent, water-based polyurethane adhesive, polyethylene glycol grafted carbon nitride nanomaterial and acetylene black are mixed in a high-speed mixer for 10 minutes, and then are fed into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 150°C for the first zone, 165°C for the second zone, 170°C for the third zone, and 170°C for the fourth zone; the mixture is stirred in a high-speed stirrer for 15 minutes, and then is pressed by a film press roller to obtain the outer packaging bag of the neutral peritoneal dialysis bag.

[0046] Example 2

[0047] The present embodiment provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably wrapped outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fraction:

[0048] The polypropylene resin is 10 parts, the polyethylene glycol is 30 parts, the talc is 7 parts, the stearic acid is 1 part, the silane coupling agent is 1 part, the thermoplastic polyurethane is 35 parts, the polyethylene glycol grafted carbon nitride nanomaterial is 10 parts, and the acetylene black is 5 parts.

[0049] The preparation method of the polyethylene glycol grafted carbon nitride nanomaterial comprises the following steps:

[0050] S1, 1g of nanometer carbon nitride powder, 120mL of mixed acid solution and 7mL of 40% hydrogen peroxide solution are mixed, heated at 70°C for 5 hours, and then filtered with a 0.22μm filter membrane to obtain hydroxylated nanometer carbon nitride, wherein the mixed acid solution is a mixed solution of nitric acid solution and sulfuric acid solution, the mass fraction concentration of the nitric acid solution is 60%, the mass fraction concentration of the sulfuric acid solution is 60%, and the volume ratio of the nitric acid solution to the sulfuric acid solution is 1:4.

[0051] S2, 1g of hydroxylated nanometer carbon nitride, 60mL of N,N-dimethylformamide, 0.6g of polyethylene glycol diglycidyl ether and 0.15mL of triethylamine are mixed, heated at 600rpm, 90°C and under nitrogen protection for 30h, and the precipitate is collected by centrifugation to obtain polyethylene glycol grafted carbon nitride nanomaterial.

[0052] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0053] The polypropylene resin, polyethylene glycol, talcum powder, stearic acid, silane coupling agent, thermoplastic polyurethane, polyethylene glycol grafted carbon nitride nanomaterial and acetylene black are mixed in a high-speed mixer for 10 minutes, and then are fed into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 160°C for the first zone, 170°C for the second zone, 175°C for the third zone and 175°C for the fourth zone; the mixture is stirred in a high-speed mixer for 15 minutes, and then is pressed by a film press to obtain the outer packaging bag of the neutral peritoneal dialysis bag.

[0054] Example 3

[0055] The present embodiment provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, wherein the outer packaging bag is detachably wrapped outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fraction:

[0056] The polypropylene resin is 5 parts, the polyethylene glycol is 25 parts, the glass fiber is 5 parts, the zinc stearate is 0.7 part, the silane coupling agent is 0.7 part, the water-based polyurethane adhesive is 30 parts, the polyethylene glycol grafted carbon nitride nanomaterial is 6 parts and the acetylene black is 3 parts.

[0057] The preparation method of the polyethylene glycol grafted carbon nitride nanomaterial comprises the following steps:

[0058] S1, 1g of carbon nitride nanomaterial powder, 100mL of mixed acid solution and 4mL of 30% hydrogen peroxide solution are mixed, heated at 60°C for 4 hours, and then filtered by a 0.22μm filter to obtain hydroxylated carbon nitride nanomaterial, wherein the mixed acid solution is a mixed solution of nitric acid solution and sulfuric acid solution, the mass fraction concentration of the nitric acid solution is 50%, the mass fraction concentration of the sulfuric acid solution is 50%, and the volume ratio of the nitric acid solution to the sulfuric acid solution is 1:3.

[0059] S2, 1g of hydroxylated carbon nitride nanomaterial, 50mL of N,N-dimethylformamide, 0.5g of polyethylene glycol diglycidyl ether and 0.1mL of triethylamine are mixed, heated at 500rpm, 80°C and under nitrogen protection for 24h, and the precipitate is collected by centrifugation to obtain polyethylene glycol grafted carbon nitride nanomaterial.

[0060] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0061] The polypropylene resin, polyethylene glycol, glass fiber, zinc stearate, silane coupling agent, water-based polyurethane adhesive, polyethylene glycol grafted carbon nitride nanometer and acetylene black are added into a high-speed mixer and mixed for 10 min, and then added into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 155℃ for the first zone, 167℃ for the second zone, 172℃ for the third zone and 172℃ for the fourth zone; the mixture is added into a high-speed stirrer and stirred for 15 min, and then pressed by a film pressing roller to obtain the outer packaging bag of the neutral peritoneal dialysis bag.

[0062] Example 4

[0063] The embodiment provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably covered outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fractions:

[0064] The polypropylene resin is 7 parts, the polyethylene glycol is 27 parts, the nanometer silicon dioxide is 6 parts, the calcium stearate is 0.8 part, the titanate coupling agent is 0.6 part, the water-based polyurethane adhesive is 29 parts, the polyethylene glycol grafted carbon nitride nanometer is 8 parts and the acetylene black is 2 parts.

[0065] The preparation method of the polyethylene glycol grafted carbon nitride nanometer comprises the following steps:

[0066] S1, 1g of nanometer carbon nitride powder, 110mL of mixed acid solution and 5mL of 30% hydrogen peroxide solution are mixed, heated at 65℃ for 3 hours, and then filtered by a 0.22μm filter membrane to obtain hydroxylated nanometer carbon nitride, wherein the mixed acid solution is a mixed solution of nitric acid solution and sulfuric acid solution, the mass fraction concentration of the nitric acid solution is 60%, the mass fraction concentration of the sulfuric acid solution is 50%, and the volume ratio of the nitric acid solution to the sulfuric acid solution is 1:3.

[0067] S2, 1g of hydroxylated nanometer carbon nitride, 50mL of N,N-dimethylformamide, 0.5g of polyethylene glycol diglycidyl ether and 0.15mL of triethylamine are mixed, heated at 500rpm, 80℃ and under nitrogen protection for 20h, and the precipitate is collected by centrifugation to obtain polyethylene glycol grafted nanometer carbon nitride.

[0068] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0069] The polypropylene resin, polyethylene glycol, nano-silicon dioxide, calcium stearate, titanate coupling agent, water-based polyurethane adhesive, polyethylene glycol grafted nano-carbon nitride and acetylene black are added into a high-speed mixer for mixing for 10 minutes, and then added into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 154℃ for the first zone, 169℃ for the second zone, 174℃ for the third zone and 174℃ for the fourth zone; the mixture is added into a high-speed stirrer for stirring for 15 minutes, and then pressed by a film press roller to obtain the outer packaging bag of the neutral peritoneal dialysis bag.

[0070] Comparative Example 1

[0071] The present comparative example provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably covered outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fraction:

[0072] 7 parts of polypropylene resin, 27 parts of polyethylene glycol, 6 parts of nano-silicon dioxide, 0.8 parts of calcium stearate, 0.6 parts of titanate coupling agent and 29 parts of water-based polyurethane adhesive.

[0073] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0074] The polypropylene resin, polyethylene glycol, nano-silicon dioxide, calcium stearate, titanate coupling agent and water-based polyurethane adhesive are added into a high-speed mixer for mixing for 10 minutes, and then added into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 154℃ for the first zone, 169℃ for the second zone, 174℃ for the third zone and 174℃ for the fourth zone; the mixture is added into a high-speed stirrer for stirring for 15 minutes, and then pressed by a film press roller to obtain the outer packaging bag of the neutral peritoneal dialysis bag.

[0075] Comparative Example 2

[0076] The present comparative example provides a neutral peritoneal dialysis bag, which comprises an outer packaging bag and a solution bag, the outer packaging bag is detachably covered outside the solution bag, and the preparation raw materials of the outer packaging bag comprise the following components in mass fraction:

[0077] 7 parts of polypropylene resin, 27 parts of polyethylene glycol, 6 parts of nano-silicon dioxide, 0.8 parts of calcium stearate, 0.6 parts of titanate coupling agent, 29 parts of water-based polyurethane adhesive and 2 parts of acetylene black.

[0078] The preparation method of the outer packaging bag of the neutral peritoneal dialysis bag comprises the following steps:

[0079] The polypropylene resin, polyethylene glycol, nano-silica, calcium stearate, titanate coupling agent, water-based polyurethane adhesive and acetylene black are added into a high-speed mixer and mixed for 10 min, and then added into a twin-screw extruder for melt extrusion to obtain a mixture, wherein the temperature of each zone of the twin-screw extruder is 154℃ for the first zone, 169℃ for the second zone, 174℃ for the third zone and 174℃ for the fourth zone; the mixture is added into a high-speed stirrer and stirred for 15 min, and then pressed by a film press roller to obtain the neutral peritoneal dialysis bag outer packaging bag.

[0080] The neutral peritoneal dialysis bag outer packaging bags in Examples 1-4 and Comparative Examples 1-2 are subjected to heat preservation effect detection in environments of 13℃ and 10℃, and the heat preservation detection results in the 13℃ environment are shown in Table 1, and the heat preservation detection results in the 10℃ environment are shown in Table 2. The heat preservation effect detection method specifically includes the following steps: 1000mL of water is added into a beaker and 27.0g of glucose, 7.74g of sodium chloride, 3.93g of sodium lactate, 0.26g of calcium chloride and 0.15g of magnesium chloride are added to simulate neutral peritoneal dialysis solution, the beaker is covered with the outer packaging bag, the beaker covered with the packaging bag is placed in a constant temperature environment of 13℃ and 10℃, and is exposed to sunlight at the same time, the beaker is taken out after 4h, the turbidity value of the solution in the beaker is measured by using a turbidimeter, then 1mL of the solution in the beaker is dropped on a glass slide, the number of crystals is observed under an optical microscope (100 times), finally, the remaining solution in the beaker is centrifuged at 3000r / min for 10min, the precipitate at the bottom is collected, and the mass of the precipitate after vacuum drying is measured.

[0081] Table 1: Heat preservation effect detection table of neutral peritoneal dialysis bag outer packaging bag (13℃ environment)

[0082] Item Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Precipitate mass (mg) 0.8 0.5 0.6 0.7 8.2 7.9 Turbidity value (NTU) 5.2 4.8 5.0 5.1 32.6 31.8 Crystallization observation No crystallization No crystallization No crystallization No crystallization Much crystallization Much crystallization

[0083] Table 2: Heat preservation effect detection table of neutral peritoneal dialysis bag outer packaging bag (10℃ environment)

[0084] Item Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Precipitate mass (mg) 1.5 1.2 1.3 1.4 12.5 12.1 Turbidity value (NTU) 8.6 8.1 8.3 8.5 45.2 44.7 Crystallization observation No crystallization No crystallization No crystallization No crystallization Caked crystallization Caked crystallization

[0085] It can be seen from Tables 1 and 2 that the neutral peritoneal dialysis bags provided in Examples 1-4 have better heat preservation effect under sunlight than the comparative examples, and can avoid the precipitation of solutes in the neutral peritoneal dialysis solution to a certain extent.

[0086] The neutral peritoneal dialysis bags in Examples 1-4 and Comparative Examples 1-2 were subjected to mechanical property detection, and the detection results are shown in Table 3. Among them, the tensile strength was tested according to GB / T 1040-2006 "Determination of tensile properties of plastics - Part 1: General principles", the tear strength was detected according to GB / T 16578.2-2009 "Determination of tear resistance of plastics films and sheets - Part 2: Elmendorf method", and the impact resistance was tested according to GB / T 8809-2015 "Plastics - Thin film pendulum impact test method".

[0087] Table 3 Mechanical property detection table of neutral peritoneal dialysis bags in Examples 1-4 and Comparative Examples 1-2

[0088] Item Tensile strength (MPa) Tear strength (kN / m) Impact resistance (kJ / m 2 ) Example 1 62 8.5 25.3 Example 2 63 8.7 26.1 Example 3 65 9.0 27.2 Example 4 64 8.8 26.5 Comparative Example 1 52 7.2 24.4 Comparative Example 2 53 7.3 24.2

[0089] The above are preferred embodiments of the present application, and are not intended to limit the protection scope of the present application, therefore, equivalent changes made on the basis of the structure, shape, principle of the present application should be covered within the protection scope of the present application.

Claims

1. A neutral peritoneal dialysis bag, comprising an outer packaging bag and a solution bag, characterized in that, The outer packaging bag is detachably wrapped around the solution bag, and the raw materials for preparing the outer packaging bag include the following components in parts by weight: 3-10 parts polypropylene resin, 20-30 parts polyethylene glycol, 3-7 parts reinforcing agent, 0.5-1 part lubricant, 0.5-1 part coupling agent, 24-35 parts binder, 5-10 parts polyethylene glycol grafted nano carbon nitride, and 1-5 parts acetylene black.

2. The neutral peritoneal dialysis bag according to claim 1, characterized in that, The preparation method of the polyethylene glycol-grafted carbon nitride nanoparticles includes the following steps: S1. Mix nano-carbon nitride, mixed acid solution and hydrogen peroxide solution, and carry out hydroxylation reaction at 50℃-70℃. Separate solid and liquid to obtain hydroxylated nano-carbon nitride. S2. The hydroxylated nano carbon nitride, N,N-dimethylformamide, polyethylene glycol diglycidyl ether and triethylamine are mixed and grafted at 70℃-90℃. After solid-liquid separation, the polyethylene glycol grafted nano carbon nitride is obtained.

3. The neutral peritoneal dialysis bag according to claim 2, characterized in that, In S1, the ratio of the amount of nano-carbon nitride, mixed acid solution, and hydrogen peroxide solution is 1g:(80-120)mL:(2-7)mL; the mixed acid solution is a mixture of nitric acid solution and sulfuric acid solution with a volume ratio of 1:2-4, wherein the mass concentration of the nitric acid solution is 40%-60%, and the mass concentration of the sulfuric acid solution is 40%-60%. The mass concentration of the hydrogen peroxide solution is 20%-40%.

4. The neutral peritoneal dialysis bag according to claim 2, characterized in that, In S1, the hydroxylation reaction takes 3-5 hours.

5. The neutral peritoneal dialysis bag according to claim 2, characterized in that, In S2, the ratio of the amount of hydroxylated nano carbon nitride, N,N-dimethylformamide, polyethylene glycol diglycidyl ether and triethylamine is 1g:(40-60)mL:(0.4-0.6)g:(0.05-0.15)mL.

6. The neutral peritoneal dialysis bag according to claim 2, characterized in that, In S2, the grafting reaction takes 18-30 hours.

7. The neutral peritoneal dialysis bag according to claim 1, characterized in that, The reinforcing agent is selected from one or more of calcium carbonate, talc, kaolin, glass fiber, nano silica, or nano clay.

8. The neutral peritoneal dialysis bag according to claim 1, characterized in that, The lubricant is selected from one or more of stearic acid, calcium stearate, zinc stearate, or paraffin.

9. The neutral peritoneal dialysis bag according to claim 1, characterized in that, The coupling agent is selected from one or both of silane coupling agents and titanate coupling agents; and / or The adhesive is selected from one or both of thermoplastic polyurethane or waterborne polyurethane adhesives.

10. The neutral peritoneal dialysis bag according to any one of claims 1-9, characterized in that, The method for preparing the outer packaging bag includes the following steps: Polypropylene resin, polyethylene glycol, reinforcing agent, lubricant, coupling agent, binder, polyethylene glycol-grafted nano carbon nitride, and acetylene black are mixed and then sequentially melt-extruded and rolled to obtain the outer packaging bag.