Essence capable of tranquilizing mind and resisting anxiety and preparation method thereof

Abstract

The invention relates to the technical field of natural plant essential oil, in particular to essence capable of tranquilizing mind and resisting anxiety and a preparation method of the essence. The essence is prepared from the following raw materials in parts by weight: 0.5 to 3 parts of clove essential oil, 7 to 8 parts of cananga odorata essential oil, 2 to 5 parts of geranium essential oil, 9 to 15 parts of lavender essential oil and ligusticum wallichii essential oil, 5 to 10 parts of microcapsule essential oil, 0.5 to 8 parts of pericarpium citri reticulatae viride essential oil, 2.3 to 3.1 parts of semen cassiae extract, 1.2 to 1.7 parts of Chinese herbaceous peony extract and 0.8 to 1.2 parts of sodium stearoyl lactylate. The core material of the microcapsule essential oil comprises the following components in parts by weight: agilawood essential oil and Roman chamomile essential oil; the essential oil has the advantage of improving the nerve-calming and anxiety-resisting effects of the essential oil.

Description

Technical Field

[0001] This application relates to the technical field of natural plant essential oils, and in particular to a calming and anti-anxiety fragrance and its preparation method. Background Technology

[0002] Sleep disorders are an increasingly prominent health problem in contemporary society, seriously affecting people's quality of life and work efficiency. Long-term sleep problems not only lead to increasing fatigue and cognitive decline, but may also trigger or aggravate various chronic diseases such as cardiovascular disease and metabolic disorders. Currently used drug treatments include benzodiazepines (such as diazepam) and non-benzodiazepines (such as zolpidem), both of which are commonly prescribed medications. However, drug treatments are often addictive, and long-term use is detrimental to health and affects efficacy. Among existing non-drug treatments, calming and anti-anxiety essential oils are gaining popularity due to their mild hypnotic effects and low side effects.

[0003] However, existing plant essential oils still have several problems that limit their calming and anti-anxiety effects. These include poor stability; some essential oil components are easily oxidized or photodegraded, leading to a rapid decrease in the content of active ingredients during storage and use. Furthermore, the synergistic effect between substances within the formula is insufficient, failing to leverage the advantages of a compound formula. While some technologies aim to improve stability by encapsulating essential oil molecules or preparing them into microcapsules, this results in excessively strong sustained-release properties, leading to a slow release rate and prolonged onset of action, resulting in a poor user experience. Summary of the Invention

[0004] In order to improve the calming and anti-anxiety effects of essential oils, this application provides a calming and anti-anxiety fragrance and its preparation method.

[0005] In the first aspect, this application provides a calming and anti-anxiety fragrance, employing the following technical solution: A calming and anti-anxiety fragrance comprising the following ingredients in parts by weight: 0.5-3 parts clove essential oil, 7-8 parts ylang-ylang essential oil, 2-5 parts geranium essential oil, 9-15 parts lavender essential oil and chuanxiong essential oil in total, 5-10 parts microcapsule essential oil, 0.5-8 parts green tangerine peel essential oil, 2.3-3.1 parts cassia seed extract, 1.2-1.7 parts peony extract, and 0.8-1.2 parts sodium stearoyl lactylate; The preparation method of the microcapsule essential oil, by weight, is as follows: S1. Wall material: Add 4-6 parts by weight of modified starch, 1-3 parts by weight of maltodextrin, 0.4-0.6 parts by weight of hydroxypropyl methylcellulose and 0.8-1.5 parts by weight of hyaluronic acid to 14-16 parts by weight of purified water, stir until completely dissolved and homogeneous to obtain the wall material. S2, Core Material: Keep the temperature below 10℃, take 2.5-3.5 parts by weight of a mixture of agarwood essential oil and Roman chamomile essential oil in a mass ratio of (1-3):1, dissolve it in 4-6 parts by weight of ethanol, add 0.4-0.7 parts by weight of alkyl glycoside and stir until dissolved to obtain the core material. S3. Keep the temperature below 10℃, add 1.5-2 parts by weight of core material to 8-12 parts by weight of wall material, stir, and obtain microcapsule essential oil.

[0006] By adopting the above technical solution, the stability of essential oils can be improved through the preparation of microcapsules, reducing the decrease in efficacy caused by the oxidation, decomposition, and volatilization of agarwood and Roman chamomile essential oils. Technically, the encapsulation performance of essential oils can be optimized through the selection of wall material raw materials. A certain amount of hyaluronic acid is added to the wall material. Hyaluronic acid is an acidic mucopolysaccharide whose unique molecular structure and physicochemical properties exhibit multiple important physiological functions in the body. While moisturizing, it is also a good transdermal absorption promoter. When used in combination with other nutrients, it can achieve a more ideal effect in promoting nutrient absorption. Adding hyaluronic acid to the wall material of this application allows it to penetrate into the skin or bind to the skin after the microcapsules come into contact with it. This causes a certain degree of rupture and collapse of the microcapsule structure, allowing the essential oil inside the microcapsule to be released and absorbed by the skin. Furthermore, hyaluronic acid can open the skin's pore channels, promoting the absorption of essential oils and thus making the calming and anti-anxiety functions of the essential oils more significant. Furthermore, this application incorporates alkyl glycosides, which enhance the emulsification of agarwood and Roman chamomile essential oils, dispersing them into smaller droplets within the wall material for better encapsulation. This improves the stability of the essential oils, accelerates their release, and promotes absorption, thereby significantly enhancing their calming and anti-anxiety effects.

[0007] Preferably, the alkyl glycoside is a C8-C14 alkyl glucoside.

[0008] By adopting the above technical solution, the alkyl glycosides in this range have a good emulsifying effect on agarwood essential oil and Roman chamomile essential oil, which can form tiny droplets after being added to the wall material and can be better encapsulated.

[0009] Preferably, the weight ratio of the lavender essential oil to the chuanxiong essential oil is (0.5-2):1.

[0010] By adopting the above technical solution, the mass ratio of lavender essential oil to Ligusticum chuanxiong essential oil is also a key factor affecting the calming and anti-anxiety effects of essential oils. The ratio of lavender essential oil to Ligusticum chuanxiong essential oil within this range can enable the essential oils to have better calming and anti-anxiety effects.

[0011] Preferably, the wall material further includes 0.1-0.3 parts by weight of ceramide.

[0012] By adopting the above technical solution and adding ceramide to the wall material, it was found that in addition to promoting the absorption of essential oils, ceramide can bind more with macromolecules in essential oils during microcapsule formation, thereby improving the stability and absorption-promoting effect of essential oils.

[0013] Preferably, the wall material also includes 0.3-0.7 parts by weight of polypeptide.

[0014] By employing the above-mentioned technical solution and adding a certain amount of peptides, the structure of the microcapsules can be made to collapse more easily, increasing the release rate of the essential oils within the microcapsules and enabling them to exert their effects more quickly. Furthermore, the peptides can penetrate the dermis, open pores, and work together with hyaluronic acid, ceramides, and other substances to promote absorption, thereby enhancing the calming and anti-anxiety effects of the essential oils.

[0015] Preferably, the polypeptide is one or more of palmitoyl pentapeptide-4, tripeptide, pentapeptide, hexapeptide, palmitoyl tetrapeptide-7, palmitoyl tetrapeptide-3, palmitoyl tripeptide-1, and palmitoyl tripeptide-5.

[0016] By adopting the above technical solutions, any polypeptide can be selected within this range. Although not all examples are listed in this application, theoretically all of them can achieve similar technical effects to the examples in this application.

[0017] Preferably, the amount of the polypeptide added is 0.5 parts by weight.

[0018] By adopting the above technical solution, the amount of peptides added should not be too much, as too much will not be conducive to the encapsulation of essential oils. This amount is the optimal amount.

[0019] Secondly, this application provides a method for preparing a calming and anti-anxiety fragrance, using the following technical solution: A method for preparing a calming and anti-anxiety fragrance, comprising the following steps: At 40-50℃, all raw materials except sodium stearoyl lactylate are mixed, and sodium stearoyl lactylate is added last. The mixture is stirred at 2000-4000 rpm for 20-40 minutes to obtain a calming and anti-anxiety fragrance.

[0020] By adopting the above technical solution and controlling the temperature, the solubility of each raw material can be improved, allowing for thorough mixing and preventing the active substances from decomposing or becoming inactive, thus maximizing the calming and anti-anxiety effects of the resulting essential oil.

[0021] In summary, this application includes at least one of the following beneficial technical effects: 1. Microcapsule preparation can improve the stability of essential oils and reduce the reduction in efficacy caused by the oxidation, decomposition, and volatilization of agarwood and Roman chamomile essential oils. Technically, the encapsulation performance of essential oils can be improved by selecting appropriate wall material raw materials. A certain amount of hyaluronic acid is added to the wall material. Hyaluronic acid is an acidic mucopolysaccharide whose unique molecular structure and physicochemical properties exhibit multiple important physiological functions in the body. While moisturizing, it is also a good transdermal absorption promoter. When used in combination with other nutrients, it can achieve a more ideal effect in promoting nutrient absorption. Adding hyaluronic acid to the wall material of this application allows it to penetrate into the skin or bind to the skin after the microcapsules come into contact with it. This causes a certain degree of rupture and collapse of the microcapsule structure, allowing the essential oil inside the microcapsule to be released and absorbed by the skin. Furthermore, hyaluronic acid can open the skin's pore channels, promoting the absorption of essential oils and thus making the calming and anti-anxiety functions of the essential oils more significant. Furthermore, this application incorporates alkyl glycosides, which enhance the emulsification of agarwood and Roman chamomile essential oils, dispersing them into smaller droplets within the wall material for better encapsulation. This improves the stability of the essential oils, accelerates their release, and promotes absorption, thereby significantly enhancing their calming and anti-anxiety effects.

[0022] 2. The fragrance prepared in this application has high safety for use; and through forced swimming, tail suspension, and spontaneous activity experiments on mice, the essential oil of this application was found to have excellent calming and anti-anxiety effects. In the forced swimming experiment on mice, the use of the essential oil of this application extended the immobility time by more than 1.7 times, with a maximum extension of 3.1 times; in the tail suspension experiment on mice, the use of the essential oil of this application extended the immobility time by more than 0.6 times, with a maximum extension of 1.1 times; and in the spontaneous activity experiment on mice, the number of spontaneous activities was reduced by more than 31.1%, with a maximum reduction of 45.3%. Detailed Implementation

[0023] The following provides a more detailed description of this application in conjunction with specific details.

[0024] raw material All raw materials used in the embodiments of this application were purchased commercially. Clove essential oil and lavender essential oil were purchased from Tiancheng Fragrance (Shenzhen) Co., Ltd.; ylang-ylang essential oil was purchased from Luyuan Natural Fragrance Oil Refining Plant, Qingyuan District, Ji'an City; geranium essential oil was purchased from Shenzhen Shanfu Biotechnology Co., Ltd.; chuanxiong essential oil was purchased from Shenzhen Dingcheng Plant Fragrance Co., Ltd.; agarwood essential oil was purchased from Yuanqi Agarwood Co., Ltd., Dianbai District, Maoming City; green tangerine peel essential oil, which is olive base oil, was purchased from Guangzhou Shengyuan Cosmetic Raw Materials Co., Ltd.; Roman chamomile essential oil was purchased from Weifang Na'ao Cosmetic Co., Ltd.; cassia seed extract, with a specification of 5% total anthraquinones from cassia seeds, was purchased from Xi'an Meihe Biotechnology Co., Ltd.; peony extract, with a specification of 90% paeoniflorin, was purchased from Xi'an Bainiankang Biotechnology Co., Ltd.; ceramide, with a purity of 98% and water solubility, was purchased from Xi'an Fenghe Biotechnology Co., Ltd.; and palmitoyl pentapeptide-4, with a purity of 98%, was purchased from Shaanxi Wensheng Biotechnology Co., Ltd. Example

[0025] Example 1 A calming and anti-anxiety fragrance, the raw materials and their amounts are shown in Table 1. The preparation method of the microcapsule essential oil is as follows: S1. Wall material: Add 5kg of modified starch, 2kg of maltodextrin, 0.5kg of hydroxypropyl methylcellulose and 1kg of hyaluronic acid to 15kg of purified water, stir until completely dissolved and uniform to obtain the wall material. S2, Core Material: Take 3 kg of a mixture of agarwood essential oil and Roman chamomile essential oil in a mass ratio of 1:1, dissolve it in 5 kg of ethanol, add 0.5 kg of alkyl glycoside, keep the temperature below 10℃, stir at 1000 rpm for 20 min to obtain the core material; the alkyl glycoside is APG0814. S3. Using a peristaltic pump, 1.8 kg of core material was pumped into 10 kg of wall material at a rate of 20 mL / min. The mixture was stirred at 1500 rpm for 30 min at 20 °C to obtain microcapsule essential oil. S4. According to the dosage in Table 1, mix all raw materials except sodium stearoyl lactylate, and finally add sodium stearoyl lactylate. Stir at 2000 rpm for 30 minutes to obtain a calming and anti-anxiety fragrance; wherein the mass ratio of lavender essential oil and Ligusticum chuanxiong essential oil is 1:1.

[0026] Table 1. Raw materials and their quantities (kg) in Example 1 Example 2 A calming and anti-anxiety fragrance differs from Example 1 in that the mass ratio of lavender essential oil to Ligusticum chuanxiong essential oil in its core material is 0.5:1, while the remaining steps are the same as in Example 1.

[0027] Example 3 A calming and anti-anxiety fragrance differs from Example 1 in that the mass ratio of lavender essential oil to Ligusticum chuanxiong essential oil in its core material is 2:1, while the remaining steps are the same as in Example 1.

[0028] Example 4 A calming and anti-anxiety fragrance differs from Example 1 in that its wall material also contains 0.2 kg of ceramide, while the remaining steps are the same as in Example 1.

[0029] Example 5 A calming and anti-anxiety fragrance, which differs from Example 4 in that its wall material also contains 0.3 kg of palmitoyl pentapeptide-4, while the rest of the steps are the same as in Example 4.

[0030] Example 6 A calming and anti-anxiety fragrance, which differs from Example 4 in that its wall material also contains 0.5 kg of palmitoyl pentapeptide-4, while the rest of the steps are the same as in Example 4.

[0031] Example 7 A calming and anti-anxiety fragrance, which differs from Example 1 in that its wall material also contains 0.7 kg of palmitoyl pentapeptide-4, while the rest of the steps are the same as in Example 4.

[0032] Comparative Example Comparative Example 1 A calming and anti-anxiety fragrance differs from Example 1 in that hyaluronic acid is not added to its wall material, while the remaining steps are the same as in Example 1.

[0033] Comparative Example 2 A calming and anti-anxiety fragrance differs from Example 1 in that the cassia seed essential oil added to its core material is replaced with an equal mass of peony essential oil, while the remaining steps are the same as in Example 1.

[0034] Comparative Example 3 A calming and anti-anxiety fragrance differs from Example 1 in that the peony essential oil added to its core material is replaced with an equal mass of cassia seed essential oil, while the remaining steps are the same as in Example 1.

[0035] Comparative Example 4 A calming and anti-anxiety fragrance differs from Example 1 in that the alkyl glycoside added to its core material is replaced with an equal mass of sodium stearoyl lactylate, while the remaining steps are the same as in Example 1.

[0036] Performance testing Detection methods / test methods The calming and anti-anxiety fragrances were prepared according to the preparation methods of Examples 1-7 and Comparative Examples 1-4, and then tested according to the following experimental detection methods. The test results are shown in Table 2.

[0037] Acute skin toxicity test: Forty-six healthy adult white mice, half male and half female, were used. Hair was removed from both sides of their backs, covering an area of ​​3×3 cm. They were divided into 23 groups of two mice each. Twenty-two groups were experimental groups, with one half designated as the intact skin group and the other as the broken skin group. The broken skin group was created by disinfecting the hair-removed skin and then pricking it with a needle until bleeding occurred. Both the intact and broken skin groups were treated with the calming and anti-anxiety fragrances from Examples 1-7 and Comparative Examples 1-4, respectively. The remaining group served as the control group. Mice were treated with 2 mL of the calming and anti-anxiety fragrance, while mice in the control group were treated with 2 mL of physiological saline. The treatment was secured with non-irritating gauze and adhesive tape, and the mice were housed separately. 24 hours after administration, the residual drug was washed off with warm water. The mice in each group were then observed for the next 7 days, including their weight, skin, fur, eyes, mucous membranes, respiration, and activity. No abnormalities were found, and there were no deaths. No significant differences were found between the mice and the control group, indicating that the calming and anti-anxiety fragrance of this application has high safety.

[0038] Test of its calming and anti-anxiety effects: Forced Swimming Experiment in Mice: Sixty adult mice were divided into 12 groups of 5 each, comprising a control group and 11 experimental groups. Hair was removed from the back of the mice (2×2 cm) using a 10% sodium sulfide solution. The experimental groups (corresponding to Examples 1-7 and Comparative Examples 1-4) received 0.1 mL of the drug applied topically to the hair removal area. The control group received 0.1 mL of physiological saline applied topically to the hair removal area. The medication was administered twice daily for 7 consecutive days. Mice were fasted for 8 hours before the last administration and tested 1 hour after administration. On day 6 before the experiment, mice were trained to swim for 15 minutes, and the test was conducted 24 hours later. Mice were placed in fiberglass tanks at a depth of 10 cm and a water temperature of 25°C, one mouse per tank. After acclimatization for 2 minutes, observation began, and the cumulative immobility time within 4 minutes was recorded. Immobility could be defined as ceasing to struggle, floating, or minimal limb movement.

[0039] Tail suspension experiment in mice: Sixty adult mice were divided into 12 groups of 5 mice each, comprising one control group and 11 experimental groups. Hair was removed from the back of the mice (2×2 cm) using a 10% sodium sulfide aqueous solution. Then, 0.1 mL of the drug was applied topically to the hair removal site in the experimental groups (corresponding to Examples 1-7 and Comparative Examples 1-4, respectively). The control group received 0.1 mL of physiological saline topically. The mice were administered the drug twice daily for 7 consecutive days. Fasting was maintained for 8 hours before the last administration, and testing was performed 1 hour after administration. The mice were secured 1 cm from the tail with adhesive tape and hung upside down in the test chamber, with their heads 4.5-7 cm from the bottom. The activity curve of the mice was displayed using the BL420E+ biological function experimental system software, and the immobility time of the mice within 6 minutes was observed and recorded.

[0040] Spontaneous Activity Experiment in Mice: Sixty adult mice were divided into 12 groups of 5 mice each. One control group and 11 experimental groups were used. Hair was removed from the back of the mice (2×2 cm) using a 10% sodium sulfide aqueous solution. Then, 0.1 mL of the drug was applied topically to the hair removal area in the experimental groups (corresponding to Examples 1-7 and Comparative Examples 1-4, respectively). The control group received 0.1 mL of physiological saline topically. The drugs were administered twice daily for 7 consecutive days. One hour after the last administration, the mice were placed in a spontaneous activity meter to measure their spontaneous activity over 5 minutes.

[0041] Calming and anti-anxiety effects of essential oils in Examples 1-7 and Comparative Examples 1-4 As can be seen from Examples 1-7, Comparative Examples 1-3, and the test data in Table 2, the fragrance prepared in this application has high safety for use. Furthermore, through forced swimming, tail suspension, and spontaneous activity experiments on mice, the essential oil of this application was found to have excellent calming and anti-anxiety effects. Specifically, in the forced swimming experiment on mice, the use of the essential oil of this application prolonged immobility time by more than 1.7 times, with a maximum extension of 3.1 times; in the tail suspension experiment on mice, the use of the essential oil of this application prolonged immobility time by more than 0.6 times, with a maximum extension of 1.1 times; and in the spontaneous activity experiment on mice, the number of spontaneous activities was reduced by more than 31.1%, with a maximum reduction of 45.3%.

[0042] Microcapsule preparation can improve the stability of essential oils and reduce the reduction in efficacy caused by the oxidation, decomposition, and volatilization of agarwood and Roman chamomile essential oils. Technically, the selection of wall material raw materials can further enhance the encapsulation performance of essential oils. A certain amount of hyaluronic acid is added to the wall material. Hyaluronic acid is an acidic mucopolysaccharide whose unique molecular structure and physicochemical properties exhibit various important physiological functions in the body, such as lubricating joints, regulating vascular permeability, regulating protein and electrolyte diffusion and transport, and promoting wound healing. Furthermore, hyaluronic acid is a multifunctional matrix widely distributed throughout the human body. It can improve skin nutrition and metabolism, making the skin soft, smooth, wrinkle-free, more elastic, and preventing aging. While moisturizing, it is also a good transdermal absorption enhancer. When used in combination with other nutrients, it can achieve a more ideal effect in promoting nutrient absorption. Adding hyaluronic acid to the wall material of this application allows it to penetrate or bind to the skin after the microcapsules come into contact with the skin, causing the microcapsule structure to rupture and collapse. This releases the essential oils inside the microcapsules, allowing them to be absorbed by the skin. Hyaluronic acid also opens skin pores, promoting the absorption of the essential oils and enhancing their overall calming and anti-anxiety effects. Furthermore, the addition of alkyl glycosides strengthens the emulsification of agarwood and Roman chamomile essential oils, dispersing them into smaller droplets within the wall material for better encapsulation. This is verified by the test data from Example 1 and Comparative Examples 1 and 4. Combined with Comparative Examples 2-3, cassia seed essential oil and peony essential oil exhibit a synergistic effect in calming and anti-anxiety effects. Combined with Examples 2-3, the mass ratio of lavender essential oil to ligusticum essential oil is also a key factor affecting the calming and anti-anxiety effects of the essential oils; a 1:1 mass ratio is the optimal ratio.

[0043] The test data from Examples 1 and 4 show that adding ceramides to the wall material not only promotes the absorption of essential oils, but also allows ceramides to bind more readily to macromolecules in the essential oils during microcapsule formation, thereby improving the stability and absorption-promoting effect of the essential oils. Combined with Examples 5-7, adding a certain amount of peptides makes the microcapsule structure easier to collapse, increasing the release rate of the essential oils and allowing them to exert their effects more quickly. Furthermore, peptides can penetrate the dermis, open pores, and work together with hyaluronic acid and ceramides to promote absorption, enhancing the calming and anti-anxiety effects of the essential oils. The test data from Examples 5-7 also indicate that the amount of peptides added should not be excessive, as excessive amounts are detrimental to the encapsulation of essential oils; an optimal addition amount is 0.5 kg.

[0044] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A calming and anti-anxiety fragrance, characterized in that: It comprises the following raw materials in parts by weight: 0.5-3 parts clove essential oil, 7-8 parts ylang-ylang essential oil, 2-5 parts geranium essential oil, 9-15 parts lavender essential oil and chuanxiong essential oil in total, 5-10 parts microcapsule essential oil, 0.5-8 parts green tangerine peel essential oil, 2.3-3.1 parts cassia seed extract, 1.2-1.7 parts peony extract, and 0.8-1.2 parts sodium stearoyl lactylate; The preparation method of the microcapsule essential oil, by weight, is as follows: S1. Wall material: Add 4-6 parts by weight of modified starch, 1-3 parts by weight of maltodextrin, 0.4-0.6 parts by weight of hydroxypropyl methylcellulose and 0.8-1.5 parts by weight of hyaluronic acid to 14-16 parts by weight of purified water, stir until completely dissolved and homogeneous to obtain the wall material. S2, Core Material: Keep the temperature below 10℃, take 2.5-3.5 parts by weight of a mixture of agarwood essential oil and Roman chamomile essential oil in a mass ratio of (1-3):1, dissolve it in 4-6 parts by weight of ethanol, add 0.4-0.7 parts by weight of alkyl glycoside and stir until dissolved to obtain the core material; S3. Keep the temperature below 10℃, add 1.5-2 parts by weight of core material to 8-12 parts by weight of wall material, stir, and obtain microcapsule essential oil.

2. The calming and anti-anxiety fragrance according to claim 1, characterized in that: The alkyl glycoside is a C8-C14 alkyl glucoside.

3. The calming and anti-anxiety fragrance according to claim 1, characterized in that: The weight ratio of lavender essential oil to chuanxiong essential oil is (0.5-2):

1.

4. The calming and anti-anxiety fragrance according to claim 1, characterized in that: The wall material also includes 0.1-0.3 parts by weight of ceramide.

5. A calming and anti-anxiety fragrance according to claim 4, characterized in that: The wall material also includes 0.3-0.7 parts by weight of polypeptide.

6. The calming and anti-anxiety fragrance according to claim 5, characterized in that: The polypeptide is one or more of palmitoyl pentapeptide-4, tripeptide, pentapeptide, hexapeptide, palmitoyl tetrapeptide-7, palmitoyl tetrapeptide-3, palmitoyl tripeptide-1, and palmitoyl tripeptide-5.

7. A calming and anti-anxiety fragrance according to claim 5, characterized in that: The amount of the polypeptide added is 0.5 parts by weight.

8. A method for preparing a calming and anti-anxiety fragrance according to any one of claims 1-7, characterized in that: It includes the following steps: At 40-50℃, all raw materials except sodium stearoyl lactylate are mixed, and sodium stearoyl lactylate is added last. The mixture is stirred at 2000-4000 rpm for 20-40 minutes to obtain a calming and anti-anxiety fragrance.

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