Composite dressing, application and preparation method thereof

Abstract

The invention discloses a composite dressing which comprises a hot-melt pressure-sensitive adhesive, a water-absorbing polymer material, a plant extract, a nano material, a transdermal absorption enhancer and a healing promoting agent, and the plant extract is selected from one or more of a leontopodium alpinum extract, an impatiens balsamina extract, tea tree essential oil, a calendula extract and a chamomile extract. According to the composite dressing based on the multi-effect composite plant extract, the leontopodium alpinum extract and the impatiens balsamina extract are compounded, the effect of the impatiens balsamina is amplified through compounding of the leontopodium alpinum, the adding amount of the impatiens balsamina is reduced, the content of the impatiens balsamina extract with high irritation is reduced, the irritation is reduced, and the effect of the impatiens balsamina is improved. Meanwhile, by compounding the leontopodium alpinum and the impatiens balsamina extract, the soothing effect can be achieved, and stimulation caused by the impatiens balsamina extract is weakened while the effect is not reduced; and a nano material is adopted as a carrier, so that the release of the extract is more sufficient, and the effect is obviously improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of dressings and patches, in particular to a composite dressing based on multi-effect composite plant extract, a patch comprising the composite dressing and a preparation method of the composite dressing. BACKGROUND

[0002] Edelweiss is a sacred flower in Tibetan culture and also a Tibetan medicine in Chinese herbal medicine, which is rich in minerals and precious ingredients such as erigeron acid. The skin care effect of edelweiss extract is mainly from the contained erigeron acid. Through in-vivo and in-vitro experimental research, it is shown that the edelweiss callus extract has strong antioxidant activity and can resist UVB damage. It also has anti-inflammatory, anti-wrinkle and moisturizing effects. In addition, it can up-regulate the expression of glutamine transaminase TG1, epidermal protein, loricrin and filaggrin in epidermal cells, thereby strengthening the skin barrier and having good prospects in cosmetic applications.

[0003] Impatiens balsamina L. extract is a substance extracted from Impatiens balsamina L. of the balsam flower family, which has the ability to scavenge free radicals and can effectively inhibit lipid peroxidation reaction. Moreover, the extract can inhibit tyrosinase activity, has antioxidant and elastase activity inhibition, provides nutritional ingredients, and promotes melanin decomposition and excretion, so it can achieve the effect of whitening in skin care.

[0004] The above two substances are widely used in the field of cosmetics, and a few large skin care brands have developed them and added them to cream emulsions. However, since cream emulsions are directly in contact with air and have a certain volatility, the effect on the skin will be greatly reduced, so the effect of plant extracts is not obvious, and the single addition of ingredients has a single and not comprehensive effect on skin care and repair.

[0005] The currently added effective ingredients in dressings are divided into three categories: antibacterial and anti-inflammatory, healing promotion, and pain relief. For antibacterial and anti-inflammatory, there are silver ions, chitosan, povidone iodine, etc. on the market. The application of silver ions may cause some allergic reactions and toxicity, and long-term use may also lead to bacterial resistance, so it is gradually disappearing from the market. Other antibacterial and anti-inflammatory agents have low skin absorption rate and do not have obvious effects, so they are not well received on the market.

[0006] The disclosure of the above background art is only used to assist in understanding the inventive concept and technical solutions of the present application, and it does not necessarily belong to the prior art of the present application. In the absence of explicit evidence that the above content was disclosed before the filing date of the present application, the above background art should not be used to evaluate the novelty and inventiveness of the present application. SUMMARY

[0007] Therefore, in order to overcome the defects of the prior art, the purpose of the present application is to provide a composite dressing based on multi-effect composite plant extract, which has better effect and lower skin irritation.

[0008] In order to achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0009] A composite dressing based on multi-effect composite plant extract, comprising hot melt pressure sensitive adhesive, water-absorbing polymer material, plant extract, nanomaterial, transdermal absorption enhancer and healing promoter, the plant extract is one or more selected from the group consisting of high mountain fireweed extract, balsam extract, tea tree essential oil, marigold extract, chamomile extract. The plant extract is used as an anti-inflammatory soothing agent.

[0010] According to some preferred embodiments of the present application, the water-absorbing polymer material and the hot melt pressure sensitive adhesive are mixed to form a hydrocolloid. The water-absorbing polymer is one or more selected from the group consisting of modified starch, gum arabic, gelatin, pectin, sodium polyacrylate, polyacrylamide, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone; the hot melt pressure sensitive adhesive is one or more selected from the group consisting of natural rubber, polyurethane rubber, silicone rubber, polyisobutylene rubber, styrene block copolymer thermoplastic elastomer, polyacrylate, polyvinyl ether.

[0011] According to some preferred embodiments of the present application, the plant extract at least includes high mountain fireweed and balsam extract. The use of high mountain fireweed and balsam extract has a synergistic advantage, which can enhance the use effect:

[0012] 1. Anti-oxidation and anti-aging: high mountain fireweed is rich in antioxidant ingredients, which can remove free radicals and delay aging; balsam extract also has antioxidant effect, and the combination of the two can enhance the antioxidant effect, reduce wrinkles and stains, and improve skin elasticity;

[0013] 2. Soothing and repair: high mountain fireweed has anti-inflammatory and soothing effect, which can relieve skin discomfort; balsam extract can promote skin metabolism and enhance skin barrier function, and the combination can improve skin sensitivity and dryness;

[0014] 3. Whitening and moisturizing: balsam extract contains whitening ingredients, which can inhibit melanin production and brighten skin color; high mountain fireweed can enhance the moisturizing ability of the skin, and the combination can make the skin whiter and more moisturizing.

[0015] Preferably, the mass ratio of the high mountain firebrush extract and the impatiens balfourii extract is 1:1-1.5. The ratio can be adjusted according to the product positioning and the skin quality of the target audience. For specific problems, such as for skin sensitivity and dryness, the proportion of high mountain firebrush extract can be appropriately increased; for whitening needs, the proportion of impatiens balfourii extract can be appropriately increased.

[0016] According to some preferred embodiments of the present application, the mass ratio of the nanomaterial and the plant extract is 1:1.5-2.

[0017] According to some preferred embodiments of the present application, the composite dressing includes the following raw material ingredients by weight:

[0018]

[0019] According to some preferred embodiments of the present application, the nanomaterial is one or more selected from nanometer titanium dioxide, nanometer zinc oxide, and silica-titanium dioxide composite material.

[0020] Preferably, the nanomaterial is silica-titanium dioxide composite material, which is used in combination with high mountain firebrush and impatiens balfourii extract. Titanium dioxide has multiple effects in improving the activity and release of plant extracts. Photo-generated carriers can cause certain chemical bonds in plant extracts to break, making it easier and more sufficient to release ingredients that are otherwise difficult to release, greatly improving the efficiency of skin absorption during the slow-release process and amplifying the efficacy. Meanwhile, titanium dioxide itself has certain antioxidant properties, and plant extracts also contain some ingredients with antioxidant activity. The antioxidant effect of titanium dioxide can synergize with these ingredients to further improve the antioxidant activity of plant extracts. The antioxidant effect of titanium dioxide can protect the active ingredients in plant extracts, reducing their loss during preparation and storage, thereby improving the activity of plant extracts.

[0021] According to some preferred embodiments of the present application, the transdermal absorption agent is one or more selected from menthol, hyaluronic acid, ceramide, soybean lecithin, shea butter, and penetration peptide.

[0022] According to some preferred embodiments of the present application, the healing-promoting agent is one or more selected from ginkgo biloba extract, nicotinamide, gotu kola extract, helwingia japonica extract, and sea fennel extract.

[0023] The present application also provides a patch, which sequentially includes a substrate layer, a body layer, and a protective layer, wherein the body layer is formed of the composite dressing as described above.

[0024] According to some preferred embodiments of the present application, the substrate layer has a groove, and the body layer is accommodated in the groove. The protective layer has a plurality of tear lines, facilitating tearing of the protective layer.

[0025] The present application also provides a preparation method of the composite dressing as described above, comprising the following steps:

[0026] Mixing the powder of the plant extract and the nanomaterial uniformly to obtain a first mixture;

[0027] Mixing the water-absorbing polymer material and the hot-melt pressure-sensitive adhesive uniformly to obtain a hydrogel body;

[0028] Mixing the hydrogel body, the first mixture, the healing-promoting agent and the transdermal absorption-promoting agent uniformly to obtain the composite dressing.

[0029] Preferably, the steps further comprise calendering, die cutting and molding the composite dressing obtained in the above steps together with the substrate layer and the protective layer to obtain the patch with the multi-effect composite plant extract.

[0030] The principle of the present application is as follows: first, the nanomaterial can produce a photocatalytic reaction under ultraviolet irradiation to produce reactive oxygen species, having certain antibacterial and anti-inflammatory effects, which helps to protect the skin from microbial infection and inflammatory reaction; second, the nanomaterial can be used as a carrier to wrap the active small molecules in the plant extract in the core, improving the stability and permeability of the active ingredients. For example, the nanosize effect and surface activity of titanium dioxide make it more easily penetrate the stratum corneum, significantly improving the skin absorption rate and bioavailability. At the same time, small molecules such as nicotinamide can be wrapped in the core, isolating light and heat and air, delaying degradation, and when released, the absorption and utilization rate of the active ingredients can be significantly improved. Using spatial wrapping technology, ingredients that are difficult to release can be released more fully; and a uniform film is formed on the skin surface, acting as a physical barrier to prevent direct contact with ultraviolet light, while also reducing the loss of skin moisture, playing a moisturizing role. The water-absorbing polymer material in the hydrogel dressing can effectively inhibit bacterial growth and prevent cell adhesion. The composite plant extract can produce anti-inflammatory, antibacterial, soothing and repairing effects around the wound at the same time, and in the process of slow and sufficient release, the effects of each component are further synergistically enhanced, making the wound healing and skin repair more perfect.

[0031] Compared with the prior art, the application has the following advantages: the composite dressing based on the multi-effect composite plant extract in the application composites the high mountain firebrush extract and the balsam extract, the composite of the high mountain firebrush amplifies the efficacy of the balsam, reduces the addition amount of the balsam, reduces the content of the balsam extract with strong irritability, and lowers the irritability, and the composite of the high mountain firebrush and the balsam extract can relieve the irritation of the balsam extract without reducing the efficacy; the use of the nanometer material as the carrier makes the release of the extract more sufficient, and the efficacy is improved more significantly. BRIEF DESCRIPTION OF DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the application, the following will briefly introduce the drawings needed to be used in the embodiments description. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative effort based on these drawings.

[0033] Figure 1 is a schematic diagram of the cross section structure of the patch in the preferred embodiment of the application;

[0034] In the drawings, the protective layer-1, the first part-21, the second part-22, and the substrate layer-3. DETAILED DESCRIPTION

[0035] In order to make the person skilled in the art better understand the technical solutions of the application, the following will combine the drawings in the embodiments of the application to clearly and completely describe the technical solutions in the embodiments of the application. Obviously, the described embodiments are only some of the embodiments of the application, not all. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative effort should belong to the protection scope of the application.

[0036] The present application aims at the problem that the effect of existing composite plant extract in skin care products is not obvious, and the healing time period of dressing products is relatively long, and designs a multi-effect composite plant extract sustained-release dressing. The present application combines nanomaterials, so that the anti-inflammatory repair effect of the composite plant extract is more fully exerted, and uses a hydrocolloid dressing to further accelerate wound healing. The water-absorbing polymer material in the hydrocolloid dressing can absorb a small amount of pus in the wound when it is first used, form a humid environment, and reduce secondary damage when the dressing is replaced; after the wound pus is absorbed, the nanomaterials form a physical barrier in the dressing and wrap the active ingredients in the plant extract inside, thereby improving the stability and permeability of the active ingredients; through the advantage of its own particle size, the nanomaterials enhance the absorption and effect in the skin, protect the skin from microbial infection and inflammatory reaction, and synergistically amplify the effects of antioxidant, antibacterial, whitening repair, etc. with the composite plant extract, thereby reducing the irritation that may be caused by a single component. The composite plant extract is released into the wound with nanomaterials as carriers, and works together with transdermal absorption agents and healing promoters.

[0037] The composite dressing based on the multi-effect composite plant extract of the present application comprises hot melt pressure sensitive adhesive, water-absorbing polymer material, plant extract, nanomaterial, transdermal absorption promoter and healing promoter, and the plant extract is one or more selected from the group consisting of high mountain firebrush extract, balsam extract, tea tree essential oil, calendula extract and chamomile extract. The plant extract is used as an anti-inflammatory soothing agent.

[0038] Preferably, the mass ratio of the composite plant extract and the nanomaterial in the hydrocolloid dressing is 5-10%; the mass ratio of the transdermal absorption agent and the healing promoter is 1-2%; the mass ratio of the water-absorbing polymer in the hydrocolloid dressing is 28-40%; and the mass ratio of the hot melt pressure sensitive adhesive in the hydrocolloid dressing is 50-65%.

[0039] The water-absorbing polymer material and the hot melt pressure sensitive adhesive are mixed to form a hydrocolloid. The water-absorbing polymer is one or more selected from the group consisting of modified starch, gum arabic, gelatin, pectin, sodium polyacrylate, polyacrylamide, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol and polyvinyl pyrrolidone; and the hot melt pressure sensitive adhesive is one or more selected from the group consisting of natural rubber, polyurethane rubber, silicone rubber, polyisobutylene rubber, styrene block copolymer thermoplastic elastomer, polyacrylate and polyvinyl ether.

[0040] The plant extract at least includes high mountain fire and crossostepholia dubia extract. The combination of high mountain fire and crossostepholia dubia extract has the following advantages: antioxidant and anti-aging: high mountain fire is rich in antioxidant ingredients, can scavenge free radicals and delay aging; crossostepholia dubia extract also has antioxidant effect, the combination of the two can enhance the antioxidant effect, reduce wrinkles and color spots, and improve skin elasticity; soothing and repair: high mountain fire has anti-inflammatory and soothing effect, can relieve skin discomfort; crossostepholia dubia extract can promote skin metabolism and enhance skin barrier function, and the combination can improve skin sensitivity and dryness; whitening and moisturizing: crossostepholia dubia extract contains whitening ingredients, can inhibit melanin production and brighten skin color; high mountain fire can enhance the moisturizing ability of the skin, and the combination can make the skin more white and moist.

[0041] The mass ratio of high mountain fire extract and crossostepholia dubia extract is 1:1-1.5. Specifically, it can be adjusted according to the product positioning and the skin condition of the target audience. For specific problems: for skin sensitivity and dryness, the proportion of high mountain fire extract can be appropriately increased; for whitening needs, the proportion of crossostepholia dubia extract can be appropriately increased.

[0042] The mass ratio of nano material and plant extract is 1:1.5-2.

[0043] The composite dressing includes the following raw material ingredients by weight:

[0044]

[0045] The nano material is one or more selected from nano titanium dioxide, nano zinc oxide, and silica-titanium dioxide composite material. Preferably, the nano material is silica-titanium dioxide composite material, which is used in combination with high mountain fire and crossostepholia dubia extract.

[0046] The nano silica can adsorb antibacterial ions through physical adsorption or chemical bonding, which can interact with biological macromolecules such as bacterial cell membranes and proteins, destroy the structure and function of bacteria, and achieve the purpose of antibiosis.

[0047] Titanium dioxide has multiple effects on improving the activity and release of plant extract. Photo-generated carriers can cause certain chemical bonds in plant extract to break, making it easier to release components that are otherwise difficult to release. Titanium dioxide itself has certain antioxidant properties, which can scavenge free radicals in the body and reduce oxidative stress damage to plant cells. Plant extract may contain some antioxidant ingredients, and the antioxidant effect of titanium dioxide can synergize with these ingredients to further improve the antioxidant activity of plant extract. The antioxidant effect of titanium dioxide can protect the active ingredients in plant extract, reduce their loss during preparation and storage, and thus improve the activity of plant extract.

[0048] The transdermal absorption agent is selected from one or more of menthol, hyaluronic acid, ceramide, soybean lecithin, shea butter, and penetration-enhancing peptides.

[0049] The healing promoter is selected from one or more of the following: Ginkgo biloba extract, nicotinamide, Centella asiatica extract, Healing velvet flower extract, and sea fennel extract.

[0050] The present invention also provides a dressing with an overall thickness of 0.2-0.4 mm. It comprises a substrate layer 3, a body layer, and a protective layer 1, wherein the body layer is formed from the composite dressing described above. The substrate layer 3 has a thickness of 0.05-0.15 mm, and the protective layer 1 has a thickness of 0.02-0.05 mm. The substrate layer 3 is release paper.

[0051] like Figure 1 As shown, the areas of the substrate layer 3 and the protective layer 1 are larger than the size of the body layer. The substrate layer 3 has grooves, and the body layer is accommodated within the grooves. The protective layer 1 has multiple tear lines, making it easy to tear open for use and allowing for better adhesion to the skin surface.

[0052] The body layer includes a first part 21 located in the middle and a second part 22 located on the outer periphery of the first part 21. The thickness of the first part 21 is greater than that of the second part 22, forming a stepped design. This allows most of the composite dressing to work on the wound while increasing breathability and providing some expansion space for the absorbent polymer to absorb pus. This prevents the dressing from falling off due to increased pressure caused by the expansion of the hydrocolloid.

[0053] The present invention also provides a method for preparing the above-mentioned composite dressing, comprising the following steps:

[0054] The powder of plant extracts was mixed evenly with nanomaterials to obtain the first mixture;

[0055] The water-absorbing polymer material and the hot-melt pressure-sensitive adhesive are mixed evenly to obtain the hydrocolloid matrix;

[0056] The hydrocolloid matrix, the first mixture, the healing promoter, and the transdermal absorption enhancer are mixed evenly to obtain a composite dressing.

[0057] Preferably, the steps further include extruding the composite dressing obtained in the above steps, and then calendering and die-cutting it together with the substrate layer 3 and the protective layer 1 to obtain a dressing with multi-effect composite plant extracts.

[0058] In some embodiments, the preparation method of the dressing specifically includes the following steps:

[0059] 1. Using a compound extraction method, extract the extract powder from Edelweiss and Impatiens balsamina.

[0060] 2. The extract powder is mixed with the nanomaterial in a high-speed dispersing machine in proportion to obtain a homogeneous first mixture;

[0061] 3. The water-absorbing polymer material and hot melt pressure-sensitive adhesive are mixed in a kneader to obtain a hydrogel main body;

[0062] 4. The hydrogel main body, the first mixture, the healing-promoting agent and the transdermal absorption promoter are mixed in a kneader to obtain a composite hydrogel dressing;

[0063] 5. The material obtained in the above step is extruded, and the substrate layer 3 and the protective layer 1 are calendered and die cut to form the multi-effect composite plant extract slow-release dressing.

[0064] The composite dressing and dressing of the present application composite the high mountain fireweed extract and the balsam extract, because the composite of the high mountain fireweed amplifies the efficacy of the balsam, reduces the addition amount of the balsam, reduces the content of the balsam extract with strong irritation, reduces the irritation, and the high mountain fireweed composite can play a soothing role, further reducing the irritation. While not reducing the efficacy, weaken the irritation brought by the balsam extract, amplify the efficacy; reduce the risk of skin allergy, suitable for more skin people to use. The nanomaterial is used as the carrier, so that the release of the extract is more sufficient, and the efficacy is improved more significantly.

[0065] Example 1

[0066] The raw material components of the multi-effect composite plant extract slow-release dressing in the present embodiment include hot melt pressure-sensitive adhesive, water-absorbing polymer, composite plant extract, nanomaterial, transdermal absorption agent and healing-promoting agent. Among them, the mass ratio of the composite plant extract and the nanomaterial in the hydrogel dressing is 5%, the mass ratio of the transdermal absorption agent and the healing-promoting agent is 1%, the mass ratio of the water-absorbing polymer in the hydrogel dressing is 34%, and the mass ratio of the hot melt pressure-sensitive adhesive in the hydrogel dressing is 60%.

[0067] Specifically, by weight, the composite dressing in the present embodiment includes the following raw material components:

[0068]

[0069] Among them, the plant extract is high mountain fireweed extract and balsam extract.

[0070] The preparation method of the dressing in the present embodiment specifically includes the following steps:

[0071] 1. The high mountain fireweed and balsam are extracted into powder by composite extraction method.

[0072] 2. Take the high mountain fire extraction, the extract of the balsam flower and the silicon-titanium dioxide composite material in a ratio of 1:1:1, and put them into a high-speed dispersion mixer for half an hour to obtain a homogeneous first mixture.

[0073] 3. Put the water-absorbing polymer and the hot melt pressure-sensitive adhesive into a kneader, and set the high temperature at 150℃ to mix them uniformly to obtain a hydrogel main body.

[0074] 4. Put the hydrogel main body, the first mixture, the transdermal absorption promoter and the healing promoter into a kneader to mix them uniformly to obtain a composite hydrogel dressing.

[0075] 5. After the composite hydrogel dressing obtained in the above step is extruded by a double screw extruder, the substrate layer 3 and the protective layer 1 are calendered and die cut to form the multi-effect composite plant extract sustained dressing.

[0076] Example 2

[0077] The raw material components of the multi-effect composite plant extract sustained dressing in this embodiment include hot melt pressure-sensitive adhesive, water-absorbing polymer, composite plant extract, nanomaterial, transdermal absorption agent and healing promoter. Among them, the mass ratio of the composite plant extract and the nanomaterial in the hydrogel dressing is 10%, the mass ratio of the transdermal absorption agent and the healing promoter is 1%, the mass ratio of the water-absorbing polymer in the hydrogel dressing is 30%, and the mass ratio of the hot melt pressure-sensitive adhesive in the hydrogel dressing is 59%.

[0078] Specifically, the composite dressing in this embodiment includes the following raw material components by weight:

[0079]

[0080] Among them, the plant extract is high mountain fire extraction and balsam flower extract.

[0081] The preparation method of the dressing in this embodiment specifically includes the following steps:

[0082] 1. Extract high mountain fire and balsam flower into powder by composite extraction method.

[0083] 2. Take the high mountain fire extraction, the extract of the balsam flower and the silicon-titanium dioxide composite material in a ratio of 1:1.5:1.5, and put them into a high-speed dispersion mixer for half an hour to obtain a homogeneous first mixture.

[0084] 3. Put the water-absorbing polymer and the hot melt pressure-sensitive adhesive into a kneader, and set the high temperature at 150℃ to mix them uniformly to obtain a hydrogel main body.

[0085] 4. The water glue body, the first mixture, the transdermal absorption promoter, and the healing promoter are added into a kneader and mixed uniformly to obtain a composite hydrocolloid dressing.

[0086] 5. The composite hydrocolloid dressing obtained in the above step is extruded by a double screw extruder, and then calendered and die cut together with the backing layer 3 and the protective layer 1 to obtain the multi-effect composite plant extract sustained-release patch.

[0087] Example 3

[0088] The raw material components of the multi-effect composite plant extract sustained-release patch in this example include hot melt pressure sensitive adhesive, water-absorbing polymer, composite plant extract, nanomaterial, transdermal absorption agent, and healing promoter. Among them, the mass ratio of the composite plant extract and the nanomaterial in the hydrocolloid dressing is 8%, the mass ratio of the transdermal absorption agent and the healing promoter is 2%, the mass ratio of the water-absorbing polymer in the hydrocolloid dressing is 40%, and the mass ratio of the hot melt pressure sensitive adhesive in the hydrocolloid dressing is 50%.

[0089] Specifically, by weight, the composite dressing in this example includes the following raw material components:

[0090]

[0091] Among them, the plant extract is high mountain firebrush extract and balsam extract.

[0092] The preparation method of the patch in this example specifically includes the following steps:

[0093] 1. The high mountain firebrush and balsam are extracted into powder by composite extraction method.

[0094] 2. The high mountain firebrush extract, balsam extract, and silicon dioxide-titanium dioxide composite material are weighed according to the ratio of 1:1.2:1.2, put into a high-speed dispersion stirrer, and dispersed for half an hour to obtain a homogeneous first mixture.

[0095] 3. The water-absorbing polymer and hot melt pressure sensitive adhesive are added into a kneader, and set to 150°C high temperature to mix uniformly to obtain a water glue body.

[0096] 4. The water glue body, the first mixture, the transdermal absorption promoter, and the healing promoter are added into a kneader and mixed uniformly to obtain a composite hydrocolloid dressing.

[0097] 5. The composite hydrocolloid dressing obtained in the above step is extruded by a double screw extruder, and then calendered and die cut together with the backing layer 3 and the protective layer 1 to obtain the multi-effect composite plant extract sustained-release patch.

[0098] Example 4

[0099] The raw material components of the multi-effect composite plant extract sustained-release patch in the embodiment include hot melt pressure-sensitive adhesive, water-absorbing polymer, composite plant extract, nanomaterial, transdermal absorption agent, and healing promoter. Among them, the mass ratio of the composite plant extract and the nanomaterial in the hydrocolloid patch is 5%, the mass ratio of the transdermal absorption agent and the healing promoter is 2%, the mass ratio of the water-absorbing polymer in the hydrocolloid patch is 28%, and the mass ratio of the hot melt pressure-sensitive adhesive in the hydrocolloid patch is 65%.

[0100] Specifically, the composite dressing in the embodiment includes the following raw material components by weight:

[0101]

[0102]

[0103] Among them, the plant extract is high mountain fireweed extract and balsam extract.

[0104] The preparation method of the patch in the embodiment specifically includes the following steps:

[0105] 1. Extract high mountain fireweed and balsam into powder by composite extraction method.

[0106] 2. Take high mountain fireweed extract, balsam extract, and silicon dioxide-titanium dioxide composite material according to a ratio of 1:1:1, put them into a high-speed dispersion mixer, and disperse for half an hour to obtain a homogeneous first mixture.

[0107] 3. Add water-absorbing polymer and hot melt pressure-sensitive adhesive to a kneader, set the high temperature to 150°C, and mix uniformly to obtain a hydrocolloid main body.

[0108] 4. Mix the hydrocolloid main body, the first mixture, the transdermal absorption promoter, and the healing promoter in the kneader to obtain a composite hydrocolloid dressing.

[0109] 5. After the composite hydrocolloid dressing obtained in the above step is extruded by a double screw extruder, the backing layer 3 and the protective layer 1 are calendered and die cut to form the multi-effect composite plant extract sustained-release patch.

[0110] Comparative Example 1

[0111] The difference between the comparative example and Example 4 is that no silicon dioxide-titanium dioxide composite material is added in the comparative example. The other formula components and preparation steps are basically the same as those of Example 4. The efficacy of the comparative example is not obvious in the test, and the residual amount of the components is relatively large.

[0112] Comparative Example 2

[0113] The difference between the present comparative example and Example 2 is that the ratio of Leontopodium leontopside extract and Impatiens balfourii extract in the present comparative example is adjusted to 1:2. Other formula components and preparation steps are basically the same as those in Example 3. The present comparative example has more obvious skin irritation in the test.

[0114] Comparative Example 3

[0115] The difference between the present comparative example and Example 2 is that the ratio of Leontopodium leontopside extract, Impatiens balfourii extract and nanomaterials in the present comparative example is adjusted to 1:1.5:3. Other formula components and preparation steps are basically the same as those in Example 3. The present comparative example has a small amount of white particles in the test.

[0116] Comparative Example 4

[0117] The difference between the present comparative example and Example 2 is that the ratio of water-absorbing polymer and hot melt pressure sensitive adhesive in the present comparative example is adjusted to 20:69. Other formula components and preparation steps are basically the same as those in Example 3. The present comparative example has fallen off from the skin surface in the test, and has no reference value.

[0118] Test and Results

[0119] The hydrocolloid dressings of M=5g, 10g and 15g prepared from the examples and comparative examples are taken respectively, and the mass of the corresponding plant extract is calculated as Xg. The dressings are attached to the surface of the animal (rabbit) skin wound for three days, and then removed and weighed to obtain the mass m1g after use. Then, butanediol and methanol are used as solvents, and high performance liquid chromatography is used for analysis and processing to draw a standard curve and obtain a regression equation of the components, so as to obtain the mass ratio a% of the residual plant extract on the dressing, and the mass m2g of the residual plant extract is obtained by m1*a%, and the residual amount = m2 / X*100%, and the results of the residual amount are shown in Table 1. At the same time, the animal (rabbit) skin wound is observed to observe the wound condition, and the results are shown in Table 2.

[0120] Table 1 Test Results

[0121]

[0122] Table 2 Wound Test Results

[0123]

[0124] From the above experimental data and phenomena, it is known that the results of Comparative Example 1 and Example 4, Comparative Example 3 and Example 2 show that the nanomaterials can help the release and absorption of plant components and amplify the efficacy; but excessive addition can cause precipitation problems and affect the fit of the dressing; the results of Comparative Example 2 and Example 2 show that the increase of the proportion of Impatiens balsamina extract will increase the efficacy, but will bring the risk of skin irritation, and the proportion thereof needs to be controlled, and the proportion of the extract of Leontopodium alpinum and the extract of Impatiens balsamina is preferably 1:1-1.5; the results of Comparative Example 4 and Example 2 show that the proportion of the water-absorbing polymer material and the pressure-sensitive adhesive in 20:69 will cause poor absorption of the dressing, affecting the adhesive viscosity.

[0125] Meanwhile, the above results show that the composite plant extract has obvious efficacy than single component addition, and can reduce the irritation caused by single component; the nanomaterials can help the release and absorption of plant extracts; the proportion of Leontopodium alpinum and Impatiens balsamina can be adjusted in the range of 1:1-1.5 according to skin quality and demand. The preferred water colloid and composite plant extract are added in the ratio of Example 2; the extract of Leontopodium alpinum, the extract of Impatiens balsamina and the nanomaterials are preferably added in the ratio of 1:1.5:1.5.

[0126] The multi-effect composite plant extract sustained-release dressing of the application achieves the effect of rapid repair and healing of wounds. The composite dressing of the application composites the extract of Leontopodium alpinum and the extract of Impatiens balsamina, amplifies the efficacy, and reduces the irritation caused by single component; the nanomaterials are used as carriers to promote the release and efficacy of the extract; by adjusting the proportion of Leontopodium alpinum and Impatiens balsamina extract, different needs of antibacterial and anti-inflammatory, whitening and repair can be effectively met.

[0127] The above examples are only for illustrating the technical concept and characteristics of the application, the purpose is to enable those skilled in the art to understand the content of the application and implement it, and cannot limit the protection scope of the application, and any equivalent changes or modifications made according to the spirit and essence of the application shall be covered within the protection scope of the application.

Claims

1. A composite dressing characterized in that, The hot melt pressure sensitive adhesive, the water-absorbing polymer material, the plant extract, the nanomaterial, the transdermal absorption enhancer and the healing promoter, wherein the plant extract is one or more selected from Ledum palustre extract, Impatiens balsamina extract, tea tree essential oil, Calendula officinalis extract and Matricaria recutita extract.

2. The composite dressing of claim 1, wherein, The plant extract at least includes Ledum palustre extract and Impatiens balsamina extract, and the mass ratio of the Ledum palustre extract to the Impatiens balsamina extract is 1:1-1.

5.

3. The composite dressing of claim 1, wherein, The mass ratio of the nanomaterial to the plant extract is 1:1.5-2.

4. The composite dressing of claim 1, wherein, The composite dressing includes the following raw material ingredients in parts by weight:

5. The composite dressing of claim 1, wherein, The nanomaterial is one or more selected from nanometer titanium dioxide, nanometer zinc oxide and silica-titanium dioxide composite material.

6. The composite dressing of claim 1, wherein, The transdermal absorption enhancer is one or more selected from menthol, hyaluronic acid, ceramide, soybean lecithin, shea nut oil and penetration peptide.

7. The composite dressing of claim 1, wherein, The healing promoter is one or more selected from Ginkgo biloba extract, nicotinamide, Centella asiatica extract, Calamintha siphonveina extract and Sea Holly extract.

8. A patch, characterized in that The composite dressing sequentially includes a substrate layer, a body layer and a protective layer, and the body layer is formed by the composite dressing according to any one of claims 1-7.

9. The patch of claim 8, wherein The substrate layer has a groove, and the body layer is accommodated in the groove.

10. A method of preparing a composite dressing according to any one of claims 1 to 7, characterised in that, The method includes the following steps: Mixing the powder of the plant extract with the nanomaterial to obtain a first mixture; Mixing the water-absorbing polymer material and the hot melt pressure sensitive adhesive to obtain a hydrogel body; Mixing the hydrogel body, the first mixture, the healing promoter and the transdermal absorption enhancer to obtain the composite dressing.

11. The method of claim 10, wherein, The method further includes calendering, die cutting and molding the composite dressing, the substrate layer and the protective layer to obtain the dressing.

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