Prebiotic composition rich in dendrobium officinale polysaccharide, tabletted candy and preparation method of prebiotic composition rich in dendrobium officinale polysaccharide and tabletted candy rich in dendrobium officinale polysaccharide

Abstract

The invention discloses a prebiotic composition rich in dendrobium officinale polysaccharides. The prebiotic composition comprises the following components in parts by weight: 10-30 parts of dendrobium officinale polysaccharides, 4-28 parts of xylooligosaccharide, 5-20 parts of stachyose, 10-30 parts of galactooligosaccharide, 4-20 parts of psyllium husk powder and 10-30 parts of taste adjusting powder. According to the prebiotic composition rich in the dendrobium officinale polysaccharide, the efficient delivery and stability of the dendrobium officinale polysaccharide are ensured through the careful selection of the raw materials and the collaborative design of the formula, and the intestinal health promotion function is improved. The invention further provides a tablet candy adopting the prebiotic composition and a preparation method of the tablet candy.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of functional food, in particular to a prebiotic combination rich in Dendrobium officinale polysaccharides, a tablet candy and a preparation method. BACKGROUND

[0002] Intestinal health is an important cornerstone of the overall health of the human body, and is closely related to nutrient absorption, immune function, metabolic regulation and even mood state. Maintaining intestinal microecological balance and promoting the growth and activity of beneficial bacteria (such as bifidobacteria and lactobacilli) are one of the key strategies to ensure intestinal health. As a food ingredient that is not easily digested by the host, prebiotics can selectively stimulate the growth and activity of beneficial bacteria in the intestine, thereby producing health benefits to the host, and has become a research hotspot and development focus in the field of functional food and health products.

[0003] Dendrobium officinale is a traditional and valuable Chinese medicinal material. Modern research shows that it is rich in various bioactive substances, among which Dendrobium officinale polysaccharides are considered to be one of the main functional ingredients. Dendrobium officinale polysaccharides have been proven to have immunomodulatory, antioxidant, anti-inflammatory, stomach-protecting and potential prebiotic-like effects, and can promote the growth of beneficial bacteria in the intestine. However, there are some problems in directly applying Dendrobium officinale polysaccharides to food or health products, such as the water solubility, dispersibility and stability of Dendrobium officinale polysaccharides in the processing process, which may affect the bioavailability of the final product, and as a raw material, the cost is relatively high. Therefore, it is necessary to efficiently utilize and improve its effect in order to reduce the cost. Therefore, in view of the problems existing in the application of Dendrobium officinale polysaccharides, it is urgent to provide a technical scheme that can effectively exert the activity and maximize the intestinal health effect. SUMMARY

[0004] The purpose of the present application is to provide a prebiotic combination rich in Dendrobium officinale polysaccharides, a tablet candy and a preparation method, which ensures the efficient delivery and stability of Dendrobium officinale polysaccharides through the selection of raw materials and the synergistic design of the formula, and improves the intestinal health promoting function.

[0005] The technical scheme adopted by the prebiotic combination rich in Dendrobium officinale polysaccharides, the tablet candy and the preparation method disclosed by the present application is as follows:

[0006] A prebiotic combination rich in Dendrobium officinale polysaccharides, comprising the following components in parts by weight: Dendrobium officinale polysaccharides 10-30 parts, xylo-oligosaccharides 4-28 parts, stachyose 5-20 parts, galacto-oligosaccharides 10-30 parts, round buckwheat seed shell powder 4-20 parts, and taste adjusting powder 10-30 parts.

[0007] As a preferred solution, the active components comprise, by weight fraction: Dendrobium polysaccharide 15-25 parts, xylo-oligosaccharide 8-15 parts, stachyose 8-12 parts, galacto-oligosaccharide 18-25 parts, psyllium husk powder 8-15 parts, and taste adjusting powder 12-18 parts.

[0008] As a preferred solution, the taste adjusting powder is specifically prune fruit powder.

[0009] A tablet candy using the above-mentioned probiotic combination, comprising the following components by weight fraction: Dendrobium polysaccharide 10-30 parts, xylo-oligosaccharide 4-28 parts, stachyose 5-20 parts, galacto-oligosaccharide 10-30 parts, psyllium husk powder 4-20 parts, taste adjusting powder 10-30 parts, erythritol 5-20 parts, microcrystalline cellulose 2-10 parts, citric acid 0.2-1.6 parts, and magnesium stearate 1-8 parts.

[0010] As a preferred solution, the tablet candy has a tablet weight of 0.5-2.0 g / tablet and a hardness of 50-100 N.

[0011] As a preferred solution, the Dendrobium polysaccharide has a content of 18-22%, a particle size of 80-200 mesh, and a polysaccharide dissolution rate of ≥85%.

[0012] A preparation method of the above-mentioned tablet candy: mixing the above-mentioned raw materials to obtain a mixture, and performing tabletting treatment to obtain the tablet candy.

[0013] As a preferred solution, the method comprises the following steps:

[0014] Dendrobium polysaccharide extraction and preparation;

[0015] Active component premixing: the Dendrobium polysaccharide, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, and psyllium husk powder are put into a three-dimensional mixer and mixed at a speed of 15-25 rpm for 10-20 minutes;

[0016] Taste adjustment: the taste adjusting powder is added and mixed for 5-15 minutes;

[0017] Food additive dispersion: the erythritol, microcrystalline cellulose, and citric acid are sieved through a 60-mesh sieve and then added and mixed until the RSD is ≤5%;

[0018] Lubricant final mixing: the magnesium stearate is added and mixed for 3-8 minutes;

[0019] Tabletting and molding: under the condition of an ambient humidity of ≤30%, a rotary tablet press is used for tabletting, the pressure is 15-25 kN, the tablet weight is controlled to be 0.5-2.0 g / tablet, and the hardness is controlled to be 50-100 N.

[0020] As a preferred solution, the Dendrobium polysaccharide extraction and preparation step comprises:

[0021] Raw material preparation: taking dendrobium officinale as raw material, crushing treatment;

[0022] Cellulase enzymolysis: add 18-20 times mass of water to the crushed raw material, add 500-4000 U / mL of cellulase, and enzymolysis extraction at 40℃ water bath condition for 0.5-2h;

[0023] Alpha-amylase enzymolysis: increase the temperature of the system to 65-70℃, add 1000-8000 U / L of alpha-amylase, and continue enzymolysis extraction for 0.5-2h;

[0024] Centrifugation and concentration: centrifugal treatment is performed on the mixed liquid after enzymolysis, the supernatant is collected, and vacuum concentration is performed;

[0025] Alcohol precipitation treatment: add 3.5-4 times volume of anhydrous ethanol to the concentrated liquid, after alcohol precipitation for 24h, discard the supernatant, and obtain the filter residue;

[0026] Freeze-drying: dissolve the filter residue in a small amount of water, and freeze-drying, to obtain dendrobium officinale polysaccharide.

[0027] The beneficial effects of the probiotic combination, tablet candy and preparation method rich in dendrobium officinale polysaccharide disclosed in the application are as follows: dendrobium officinale polysaccharide, xylo-oligosaccharide, stachyose, galacto-oligosaccharide and plantago ovata seed husk powder are scientifically matched. Dendrobium officinale is rich in polysaccharide with probiotic activity, which interacts with the complex probiotic to synergistically enhance the selective proliferation of intestinal beneficial bacteria, effectively optimizing the intestinal flora structure; at the same time, dendrobium officinale polysaccharide itself has the functions of immune regulation and intestinal mucosa protection, which, combined with the effects of probiotics promoting bacteria and dietary fiber promoting excretion, work in coordination, improve the intestinal microenvironment in multiple dimensions, and significantly improve the intestinal health efficacy and comprehensive nutritional value of the composition.

[0028] The tablet candy is prepared by using the tabletting process, which effectively overcomes the common problems of water solubility and dispersibility of dendrobium officinale polysaccharide in application, ensuring high dissolution rate and bioavailability; in the preparation process, through the optimized steps of active ingredient premixing, dietary fiber integration, additive dispersion and lubricant final mixing, using microcrystalline cellulose as a dispersion carrier, and strictly controlling the process conditions in the tablet forming stage, the damage to the structure of heat-sensitive dendrobium officinale polysaccharide in the processing process is minimized, ensuring the molecular integrity and biological activity; at the same time, through the compounding of erythritol and citric acid, the herbal astringency of dendrobium officinale polysaccharide is effectively masked, and the taste palatability of the tablet candy is improved. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 Comparison chart of polysaccharide yield of dendrobium officinale polysaccharide extracted by double enzyme method and enzyme-free water extraction method. DETAILED DESCRIPTION

[0030] The application will be further described and explained with reference to the specific embodiments and the accompanying drawings:

[0031] Example 1

[0032] A kind of intestinal health function of Dendrobium officinale polysaccharide-rich prebiotic composition, including the following components:

[0033] Dendrobium officinale polysaccharide powder 25 g, xylo-oligosaccharide 10 g, stachyose 15 g, galacto-oligosaccharide 10 g, psyllium husk powder 10 g, prune fruit powder 10 g

[0034] The prebiotic activity of the prebiotic composition described in Example 1 is verified:

[0035] Strains: Bifidobacterium infantis, Lactobacillus acidophilus

[0036] The strains used in the examples and comparative examples are obtained from the China Industrial Microbial Culture Collection Center: Bifidobacterium infantis (preservation number: CICC6069), Lactobacillus acidophilus (preservation number: CICC6074)

[0037] Culture medium: basic medium: MRS liquid medium (pH 6.8)

[0038] Grouping:

[0039] Test group: basic medium + 2% Example 1 composition

[0040] Positive control: basic medium + 2% fructo-oligosaccharide (FOS)

[0041] Negative control: basic medium (without carbon source)

[0042] Detection:

[0043] 37℃ anaerobic culture for 24h, OD (bacterial density) and short-chain fatty acid (SCFA) production are measured. 600

[0044] The results are shown in Table 1:

[0045] Table 1

[0046] Group Bifidobacterium proliferation rate (fold of negative control) SCFA production (μmol / mL) Negative control 1.0× 8.2±1.1 Positive control (FOS) 3.8× 32.6±2.8 Example 1 composition 5.2× 46.3±3.5

[0047] Conclusion:

[0048] The proliferation rate of the composition on Bifidobacterium is significantly better than that of single prebiotic FOS (p<0.05);

[0049] The production of short-chain fatty acids (acetic acid + propionic acid) is increased by 41.8%, confirming the synergistic prebiotic activity.

[0050] ​Comparative Example 1: Prebiotic composition lacking Dendrobium polysaccharides

[0051] A prebiotic composition lacking Dendrobium polysaccharides comprising the following components by weight:

[0052] Xylooligosaccharides 10 g, stachyose 15 g, galactooligosaccharides 10 g, psyllium husk powder 10 g, prune fruit powder 10 g

[0053] The following tests were performed using the prebiotic activity verification method of Reference Example 1:

[0054] Strains: Bifidobacterium infantis, Lactobacillus acidophilus

[0055] Culture medium: basal medium (MRS liquid medium, pH 6.8)

[0056] Grouping:

[0057] Positive control: basal medium + 2% fructooligosaccharides (FOS)

[0058] Negative control: basal medium (without carbon source)

[0059] Example 1 control group: basal medium + 2% Example 1 composition (containing Dendrobium polysaccharides)

[0060] Comparative Example 1 test group: basal medium + 2% Comparative Example 1 composition

[0061] Test:

[0062] 37°C anaerobic culture for 24 h, determination of OD 600 (bacterial density) and short-chain fatty acid (SCFA) production.

[0063] Results are shown in Table 2:

[0064] Table 2

[0065]

[0066] Conclusion:

[0067] The proliferation rate of the Comparative Example 1 composition (lacking Dendrobium polysaccharides) on Bifidobacterium (2.9x) was significantly lower than that of the Example 1 composition (5.2x, p<0.01) and lower than that of the positive control FOS (3.8x, p<0.05); its SCFA production (25.8±2.3 μmol / mL) was also significantly lower than that of Example 1 (46.3±3.5 μmol / mL, p<0.01).

[0068] Comparative Example 2: Single prebiotic formula (only Dendrobium polysaccharides)

[0069] A composition containing only a single prebiotic (only Dendrobium polysaccharide), including the following components by weight:

[0070] Dendrobium polysaccharide 80g

[0071] The following tests were conducted by referring to the prebiotic activity verification method of Example 1:

[0072] Strain: Bifidobacterium infantis

[0073] Culture medium: basic medium (MRS liquid medium, pH 6.8)

[0074] Grouping:

[0075] Negative control: basic medium (without carbon source)

[0076] Positive control: basic medium + 2% fructooligosaccharide (FOS)

[0077] Example 1 control group: basic medium + 2% Example 1 composition (containing Dendrobium polysaccharide + complex prebiotic)

[0078] Test group of Comparative Example 2: basic medium + 2% composition of Comparative Example 2 (only Dendrobium polysaccharide)

[0079] Test:

[0080] 37℃ anaerobic culture for 24h, determination of OD 600 (bacterial density) and short-chain fatty acid (SCFA) production.

[0081] Results are shown in Table 3:

[0082] Table 3

[0083]

[0084] Conclusion:

[0085] The Bifidobacterium proliferation rate (2.1x) and SCFA production (18.5±2.1 μmol / mL) of Comparative Example 2 (only Dendrobium polysaccharide) were significantly lower than those of Example 1 composition (5.2x, 46.3±3.5 μmol / mL, p<0.01), and lower than those of positive control FOS (3.8x, 32.6±2.8 μmol / mL, p<0.05).

[0086] Example 2:

[0087] A tablet candy with intestinal health function rich in Dendrobium polysaccharide, including the following components:

[0088] Dendrobium polysaccharide powder 25g, xylo-oligosaccharide 10g, stachyose 15g, galacto-oligosaccharide 10g, psyllium husk powder 10g, prune fruit powder 10g, erythritol 8g, microcrystalline cellulose 10g, citric acid 1.2g, magnesium stearate 1.8g

[0089] A preparation method of a tabletted candy with rich Dendrobium polysaccharide and intestinal health function, comprising the following steps:

[0090] High-efficiency extraction and preparation of Dendrobium polysaccharide:

[0091] After the Dendrobium raw material is crushed, 20 times the mass of water is added, 500-4000 U / mL of cellulase is added, and water bath extraction is performed at 40℃ for 0.5-2h; the temperature is increased to 70℃, 1000-8000 U / L of α-amylase is added, and enzymatic extraction is performed for 0.5-2h; centrifugation is performed, the supernatant is collected, and vacuum concentration is performed. 4 times the volume of the concentrated liquid of anhydrous ethanol is added for alcohol precipitation for 24h, the supernatant is discarded, and the filter residue is obtained. The filter residue is dissolved in a small amount of water and freeze-dried to a water content of ≤5%, and is crushed by an airflow crusher to 150 mesh (particle size 100±20μm).

[0092] Premixing of active ingredients:

[0093] The pretreated Dendrobium polysaccharide, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, and psyllium husk powder are put into a three-dimensional mixer and mixed at 20rpm for 15 minutes.

[0094] Taste deployment:

[0095] Prune fruit powder is added and mixed for 10 minutes.

[0096] Dispersion of food additives:

[0097] The erythritol, microcrystalline cellulose, and citric acid are sieved through a 60-mesh sieve and added to the mixture, and mixed until the content uniformity (RSD≤4%) is achieved.

[0098] Final mixing of lubricants:

[0099] Magnesium stearate is added and mixed for 5 minutes.

[0100] Tabletting and molding:

[0101] The environmental humidity is controlled to be ≤30%, a rotary tablet press (pressure 20kN) is used, and a tabletted candy with a tablet weight of 1.0g / tablet and a hardness of 70N is prepared.

[0102] The product performance of the tabletted candy with rich Dendrobium polysaccharide and intestinal health function is shown in Table 4:

[0103] Table 4

[0104]

[0105]

[0106] Example 3: Experiment on the improvement of constipation symptoms in a mouse model using a prebiotic composition

[0107] Experimental materials

[0108] Test substance:

[0109] Experimental group: Example 1 Prebiotic composition (powder, polysaccharide content 215mg / g)

[0110] Positive control: Lactulose oral solution (a commonly used clinical laxative)

[0111] Negative control: physiological saline

[0112] Laboratory animals:

[0113] SPF grade Balb / c mice, 6 weeks old, male, weighing 20±2g

[0114] Grouping: Blank control group (6 birds), model control group (6 birds), positive control group (6 birds), experimental low / medium / high dose group (6 birds each)

[0115] Modeling reagents:

[0116] Loperamide (inhibits intestinal motility, induces a constipation model), concentration 5 mg / mL

[0117] Experimental methods

[0118] Constipation Model Construction

[0119] step:

[0120] Mice were acclimatized for 7 days with free access to food;

[0121] Except for the blank control group, mice in the other groups were administered loperamide (10 mg / kg, 100 μL / ml) by gavage daily.

[0122] (Only), for 3 consecutive days, to establish a constipation model (judgment criteria: the number of bowel movements is reduced by ≥50% compared to normal, and the stool is dry and granular).

[0123] The dosing regimen is shown in Table 5.

[0124] Table 5

[0125]

[0126]

[0127] Observation indicators

[0128] Defecation: The number of fecal pellets, fecal wet weight and fecal character (0-3 points: 0 point = normal soft stool; 1 point = mild dry knot; 2 points = granular hard stool; 3 points = no defecation) were recorded daily.

[0129] First pellet defecation time: After the last administration, the time of the first defecation of the mice was recorded.

[0130] Intestinal propulsion rate: After 1 hour of the last administration, the mice were gavaged with a charcoal suspension (5%, 100 μL / each), and 30 minutes later, the mice were sacrificed, and the percentage of the propulsion distance of the charcoal in the small intestine to the total length of the small intestine was measured.

[0131] Experimental results

[0132] Improvement of defecation symptoms (data on day 7) is shown in Table 6

[0133] Table 6

[0134]

[0135]

[0136] Note: *p <0.05, **p <0.01, ***p <0.001 (vs model control group, t-test)

[0137] Experimental conclusion

[0138] Dose-dependent improvement: The high-dose group (200 mg / kg) can significantly increase the number of fecal pellets (10.3 pellets / day vs 3.2 pellets / day in the model group), shorten the first pellet defecation time (52.6 min vs 185.6 min in the model group), and improve the intestinal propulsion rate (68.5% vs 22.3% in the model group), which is better than the positive control drug (lactulose).

[0139] Mechanism of action: Dendrocalamus latiflorus polysaccharides, in cooperation with oligosaccharides such as xylo-oligosaccharides and stachyose, can promote the proliferation of beneficial bacteria in the intestine, increase the secretion of short-chain fatty acids (SCFA), and stimulate intestinal mucosal peristalsis; Plantago ovata husk powder and prune fruit powder can absorb water and soften feces, improving fecal character, and the two work together to relieve constipation from multiple dimensions of "stimulating peristalsis and softening feces".

[0140] Example 4: Human trial case for improving constipation symptoms

[0141] Thirty people (aged 20-60 years old, all with a history of constipation for ≥3 months) were recruited as subjects, and the subjects were grouped according to the following table 8:

[0142] Table 8

[0143]

[0144]

[0145] Evaluation criteria:

[0146] ① Defecation frequency: number of defecation per week

[0147] ② Stool form: based on Bristol stool form scale (types 1-2 are constipation, 3-5 are normal)

[0148] ③ Abdominal distension relief: mild (does not affect life), moderate (affects activity), severe (cannot be tolerated)

[0149] The improvement effect of the tablet candy of Example 1 on constipation of the subjects was as follows:

[0150] After the subjects used the test product continuously for 7 days, 86.7% of the subjects reported improvement in constipation.

[0151] After comparison before and after use, the defecation frequency and abdominal distension relief rate of the subjects were improved. Details are shown in Table 9.

[0152] Table 9

[0153] Index Test group (after use) Control group (after use) Significance (p value) Constipation improvement rate 86.7% (13 / 15 people) 20.0% (3 / 15 people) <0.001 Defecation frequency 5.8 ± 0.9 times / week 3.5 ± 0.7 times / week <0.01 Fecal character conversion to normal 80.0% (12 / 15 people) 13.3% (2 / 15 people) <0.001 Abdominal distension relief rate 73.3% (11 / 15 people) 6.7% (1 / 15 people) <0.001

[0154] Typical case: 56-year-old female (frequent abdominal distension, defecation difficulty):

[0155] On the first day of taking: 1 tablet after meal, slight abdominal distension without abdominal pain.

[0156] On the second day of taking: increased defecation amount and slight shaping.

[0157] On the seventh day of taking: regular defecation (1 time / day), complete relief of abdominal distension.

[0158] Example 5: Case of regulating diarrhea and indigestion

[0159] 25 people were recruited as subjects, and the subject information was as follows:

[0160] Number of people: 25 (age 19-37, symptoms: alternating constipation / diarrhea, indigestion);

[0161] Plan: 3 tablets per day (taken after meal), continuously for 7 days.

[0162] The improvement effect of the tablet candy of Example 1 on diarrhea and indigestion of the subjects was as follows:

[0163] Diarrhea improvement: 52.1% reduction in incidence of watery stool (from 2.8 ± 0.6 times / day to 1.3 ± 0.4 times / day, p < 0.05).

[0164] Indigestion relief: improvement rate of loss of appetite: 81.8% (9 / 11 people)

[0165] Undigested fecal residue disappearance rate: 75.0% (6 / 8 people)

[0166] Overall effect: 78.3% of subjects reported significant improvement in intestinal discomfort symptoms, and no cases of abdominal pain or diarrhea worsened.

[0167] Typical case: 20-year-old female (diarrhea after breakfast, feces not formed):

[0168] Days 1-2: Take 2 tablets / day, and the stool is still slightly unformed.

[0169] Day 5: Increase to 3 tablets / day, and the stool formation is significantly improved (Bristol type 4).

[0170] Example 6: Long-term safety verification

[0171] Thirty subjects were recruited to take the tablet candy of Example 1 continuously for 6 months (2 tablets / day).

[0172] Results:

[0173] There were no abnormal changes in blood routine, liver and kidney function indicators.

[0174] No gastrointestinal irritation, allergy, or other adverse reactions were reported.

[0175] The taste acceptance score was ≥4.2 / 5 points (based on balance of sweet and sour and no astringent taste).

[0176] And the prune fruit powder is used for taste adjustment, which not only increases palatability, but also effectively promotes intestinal peristalsis, improves constipation, and assists in maintaining intestinal flora balance, thereby having a positive impact on intestinal health.

[0177] The present application provides a kind of rich in Dendrobium officinale Kimura et Migo polysaccharide prebiotic combination, tablet candy and preparation method, Dendrobium officinale Kimura et Migo polysaccharide, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, round isochrysum seed shell powder Scientific compatibility.Dendrobium officinale Kimura et Migo rich in polysaccharide with prebiotic activity, which interacts with each other with complex prebiotics, synergistic effect, significantly enhanced the selective proliferation of intestinal beneficial bacteria, effectively optimized the intestinal flora structure;At the same time, Dendrobium officinale Kimura et Migo polysaccharide itself has the immune regulation and intestinal mucosa protection function, combined with the effect of prebiotics promoting bacteria and dietary fiber promoting discharge, coordinated work, multi-dimensional improvement intestinal microenvironment, significantly improve the intestinal health efficacy and comprehensive nutritional value of composition.

[0178] The prepared tablet candy effectively overcomes the problems of water solubility and dispersibility of Dendrobium candidum polysaccharide in application, guarantees high dissolution rate and bioavailability; in the preparation process, through optimized active component premixing, dietary fiber integration, additive dispersion and lubricant final mixing steps, microcrystalline cellulose is used as a dispersion carrier, and the process conditions are strictly controlled in the tablet forming stage, so that the destruction of the structure of heat-sensitive Dendrobium candidum polysaccharide in the processing process is minimized, the molecular integrity and biological activity are guaranteed; at the same time, through the compounding of erythritol and citric acid, the herbal astringent taste of Dendrobium candidum polysaccharide is effectively masked, and the taste palatability of the tablet candy is improved.

[0179] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application, and are not a limitation on the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced equivalently without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A prebiotic combination enriched with Dendrobium candidum polysaccharides, characterized in that, The tabletted candy comprises the following components in parts by weight: 10-30 parts of dendrobium officinale polysaccharide, 4-28 parts of xylo-oligosaccharide, 5-20 parts of stachyose, 10-30 parts of galacto-oligosaccharide, 4-20 parts of ispaghula husk powder, and 10-30 parts of taste adjusting powder.

2. The prebiotic combination enriched with Dendrobium candidum polysaccharides according to claim 1, characterized in that, The tabletted candy comprises the following preferred components in parts by weight: 15-25 parts of dendrobium officinale polysaccharide, 8-15 parts of xylo-oligosaccharide, 8-12 parts of stachyose, 18-25 parts of galacto-oligosaccharide, 8-15 parts of ispaghula husk powder, and 12-18 parts of taste adjusting powder. 3.The Dendrobium candidum polysaccharide-enriched prebiotic combination of claim 1 or 2, characterized in that, The taste adjusting powder is specifically prune fruit powder.

4. A tabletted confectionery employing the combination of prebiotics according to any one of the preceding claims 1 to 3, characterized in that, The tabletted candy comprises the following components in parts by weight: 10-30 parts of dendrobium officinale polysaccharide, 4-28 parts of xylo-oligosaccharide, 5-20 parts of stachyose, 10-30 parts of galacto-oligosaccharide, 4-20 parts of ispaghula husk powder, 10-30 parts of taste adjusting powder, 5-20 parts of erythritol, 2-10 parts of microcrystalline cellulose, 0.2-1.6 parts of citric acid, and 1-8 parts of magnesium stearate.

5. A tabletted confectionery product according to claim 4, wherein the tabletted confectionery product comprises a plurality of the confectionery pieces. The tabletted candy has a tablet weight of 0.5-2.0 g / tablet and a hardness of 50-100 N.

6. A tabletted confectionery product according to claim 5, characterised in that The dendrobium officinale polysaccharide has a content of 18-22%, a particle size of 80-200 mesh, and a polysaccharide dissolution rate of ≥85%.

7. A process for the preparation of tabletted sweets as claimed in any of the preceding claims 4 to 6, characterised in that, The above raw materials are mixed to obtain a mixture, and the mixture is subjected to tabletting to obtain the tabletted candy.

8. A process for the preparation of a tabletted confectionery according to claim 7, characterised in that, The method comprises the following steps: Dendrobium officinale polysaccharide extraction and preparation; Active component premixing: the dendrobium officinale polysaccharide, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, and ispaghula husk powder are put into a three-dimensional mixer and mixed at a speed of 15-25 rpm for 10-20 minutes; Taste adjustment: the taste adjusting powder is added and mixed for 5-15 minutes; Food additive dispersion: the erythritol, microcrystalline cellulose, and citric acid are sieved through a 60-mesh sieve and then added and mixed until the RSD is ≤5%; Lubricant final mixing: the magnesium stearate is added and mixed for 3-8 minutes; Tabletting: the tabletting is performed under the condition that the ambient humidity is ≤30% by using a rotary tablet press at a pressure of 15-25 kN, the tablet weight is controlled to be 0.5-2.0 g / tablet, and the hardness is controlled to be 50-100 N.

9. A process for the preparation of a tabletted confectionery according to claim 8, characterised in that, The dendrobium officinale polysaccharide extraction and preparation step comprises: Raw material preparation: the dendrobium officinale is used as a raw material and subjected to crushing; Cellulase enzymolysis: 18-20 times the mass of water is added to the crushed raw material, 500-4000 U / mL of cellulase is added, and the system is subjected to enzymolysis extraction at 40°C in a water bath for 0.5-2 h; Alpha-amylase enzymolysis: the temperature of the system is increased to 65-70°C, 1000-8000 U / L of alpha-amylase is added, and the system is subjected to enzymolysis extraction for 0.5-2 h; Centrifugation and concentration: the mixed solution after enzymolysis is subjected to centrifugal treatment, the supernatant is collected, and vacuum concentration is performed; Alcohol precipitation treatment: 3.5-4 times the volume of anhydrous ethanol is added to the concentrated solution, alcohol precipitation is performed for 24 h, the supernatant is discarded, and filter residue is obtained; Freeze-drying: the filter residue is dissolved in a small amount of water and subjected to freeze-drying to obtain the dendrobium officinale polysaccharide.

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