Synthesis method of 2, 3-dimethoxybenzaldehyde

Abstract

The invention belongs to the technical field of chemical synthesis, and relates to a synthesis method of 2, 3-dimethoxybenzaldehyde. According to the invention, o-dimethoxybenzene reacts with butyl lithium in an organic solvent system, and butyl lithium is used as a strong base to'remove 'hydrogen atoms at specific positions in o-dimethoxybenzene molecules, so that an active intermediate 2, 6-dimethoxyphenyl lithium is formed. The intermediate has electronegative phenyl carbon anions, has relatively strong nucleophilic ability, and provides good reaction sites for subsequent formylation reaction, so that the yield of the target product 2, 3-dimethoxybenzaldehyde can reach a relatively high level, the purity of the target product 2, 3-dimethoxybenzaldehyde also reaches an industrial application standard, and the utilization rate of raw materials and the market competitiveness of the product are greatly improved.

Description

Technical Field

[0001] This invention belongs to the field of chemical synthesis technology and relates to a method for synthesizing 2,3-dimethoxybenzaldehyde. Background Technology

[0002] Berberine, chemically known as berberine hydrochloride, is an isoquinoline alkaloid extracted from traditional Chinese medicinal herbs such as Coptis chinensis and Phellodendron amurense. It holds an indispensable position in the pharmaceutical field due to its significant antibacterial, anti-inflammatory, antiarrhythmic, hypoglycemic, and antitumor pharmacological activities. With the deepening application of berberine in clinical treatment and pharmaceutical research, market demand continues to rise. This has not only promoted the development of the berberine industry but also placed higher demands on the supply of 2,3-dimethoxybenzaldehyde, a key intermediate in the synthesis of berberine. The quality and yield of 2,3-dimethoxybenzaldehyde directly affect the synthesis efficiency and production cost of berberine; therefore, improving its synthesis technology is crucial to enhancing berberine production capacity.

[0003] However, current methods for synthesizing 2,3-dimethoxybenzaldehyde face numerous challenges. Traditional synthetic processes typically involve complex reaction steps, resulting in low atom utilization, demanding harsh reaction conditions, and the use of toxic and hazardous reagents, generating substantial waste and increasing production costs while placing significant pressure on the environment. For example, the route using catechol as a raw material, methylating it via dimethyl sulfate, and then achieving formylation via the Remmer-Tiemann reaction, while capable of producing the target product, suffers from the high toxicity and carcinogenic risk of dimethyl sulfate, and the high cost of wastewater treatment. The Remmer-Tiemann reaction, on the other hand, is highly toxic due to the use of halogenated hydrocarbons such as chloroform, requires harsh reaction conditions, involves numerous side reactions, has a product yield as low as 50%-60%, and requires complex separation and purification processes. Furthermore, while some synthetic processes employing complex catalyst systems or multi-step reactions have attempted to solve some problems, their high catalyst costs and difficulty in recycling, or the cumbersome overall synthetic steps leading to low overall yields, severely impact the production efficiency of 2,3-dimethoxybenzaldehyde and the economic benefits of its downstream products. This, in turn, hinders the sustainable development of berberine and related pharmaceutical industries. Therefore, developing an efficient, green, and low-cost synthetic technology for 2,3-dimethoxybenzaldehyde is particularly urgent and is one of the current key research directions. By innovating synthetic routes, reducing the use of harmful substances, optimizing reaction conditions, and improving atom economy and product yield, we can effectively promote the development of berberine and related pharmaceutical industries towards a more environmentally friendly and economical direction. Summary of the Invention

[0004] The purpose of this invention is to address the aforementioned problems in the existing technology by proposing a method for synthesizing 2,3-dimethoxybenzaldehyde, which yields 2,3-dimethoxybenzaldehyde with high purity, a short preparation cycle, and a green and environmentally friendly preparation process.

[0005] The objective of this invention can be achieved through the following technical solutions:

[0006] A method for synthesizing 2,3-dimethoxybenzaldehyde, the method comprising the following steps:

[0007] S1. A nucleophilic substitution reaction was carried out between o-phenylenedimethyl ether and butyllithium in an organic solvent to give 2,3-dimethoxyphenyllithium;

[0008] S2. 2,3-Dimethoxyphenyllithium is subjected to a formylation reaction, and finally neutralized by acidification to obtain 2,3-dimethoxybenzaldehyde.

[0009] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the molar ratio of o-phenylene dimethyl ether to butyllithium in step S1 is 1:(0.5-1.5).

[0010] In the synthesis method of 2,3-dimethoxybenzaldehyde provided by this invention, the nucleophilic substitution reaction is the key initiating step of the entire synthetic route, and its mechanism and role have a decisive influence on the smooth progress of subsequent reactions. The substitution reaction refers to the removal of a proton (H+) from an organic molecule in the presence of butyllithium. + The process involves the formation of corresponding organometallic compounds. Specifically, in step S1, phthalic acid reacts with butyllithium in an organic solvent system. Butyllithium, acting as a strong base, removes hydrogen atoms from specific positions in the phthalic acid molecule, thereby forming the active intermediate—2,3-dimethoxyphenyllithium. This intermediate carries a negatively charged phenyl carbanion, possessing strong nucleophilic ability, providing a favorable reaction site for the subsequent formylation reaction. The mechanism of this reaction is typical of the formation process of aryl lithium. Due to the electron-donating effect of the two methoxy groups (–OCH3) in the phthalic acid molecule, certain hydrogen atoms on the benzene ring can be activated, making them easier to remove by a strong base, thus promoting the formation of aryl lithium. This invention improves the selectivity and efficiency of the reaction by controlling the appropriate reaction temperature and molar ratio. The amount of butyllithium used in this invention is crucial. If butyllithium is used in excess, it will not only waste raw materials but also trigger side reactions. For example, excess butyllithium may attack hydrogens at other positions on the benzene ring or participate in unnecessary coupling reactions, generating structurally complex byproducts that affect the purity and yield of the target product. If butyllithium is insufficient, it will lead to incomplete conversion of o-phenylenediamine, reduce reaction efficiency, affect the amount of subsequent intermediates generated, and ultimately affect the overall yield.

[0011] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the nucleophilic substitution reaction in step S1 is carried out at a temperature of -78℃ to 20℃ for a time of 8 to 24 hours.

[0012] The butyllithium substitution reaction is essentially an exothermic process involving butyllithium, making it highly reactive. Excessive reaction temperature significantly accelerates side reactions; for example, butyllithium may non-selectively attack other hydrogen atoms or solvent molecules on the benzene ring, leading to the formation of various byproducts with unknown structures, introducing impurities and reducing the selectivity and purity of the target intermediate. Furthermore, high temperatures exacerbate the decomposition of organolithium compounds, further affecting the stability of the reaction system. When the temperature exceeds 20°C, the impurity content increases significantly, severely impacting the subsequent formylation reaction. Conversely, while excessively low reaction temperatures can suppress side reactions, the increased viscosity and slowed molecular motion reduce effective collisions between reactants, leading to a decrease in the reaction rate and feedstock conversion rate, potentially by more than 20%. This results in insufficient conversion of dimethyl ether into the active aryl lithium intermediate, ultimately affecting the yield of the target product and the overall process economy. Secondly, controlling the reaction time is crucial to ensure the substitution reaction completes the necessary time window for full conversion under suitable temperature conditions. If the reaction time is too short, the dimethyl ether may not be completely deprotonated, resulting in insufficient intermediate formation; while if the reaction time is too long, side reactions may accumulate, especially at slightly higher temperatures, making it easier to generate unnecessary byproducts. Therefore, this invention sets 8–24 hours as the optimal reaction time range, which ensures the reaction proceeds fully while avoiding the risk of side reactions caused by prolonged reactions, thus helping to obtain high-purity, high-yield 2,3-dimethoxyphenyl lithium intermediates.

[0013] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the organic solvent includes at least one of tetrahydrofuran, 2-methyltetrahydrofuran, and methyl tert-butyl ether.

[0014] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the formylation reaction in step S2 is carried out at a temperature of -78℃ to 20℃ for a time of 0.5 to 3 hours.

[0015] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, in step S2, 2,3-dimethoxyphenyllithium undergoes a formylation reaction with an aldehyde donor.

[0016] This invention achieves a crucial transformation from aryllithium intermediates to aldehydes via formylation, serving as an important bridge connecting the aromatic skeleton and oxygen-containing functional groups in the synthetic route. Furthermore, this reaction indirectly affects the distribution pattern of substituents on the benzene ring, ensuring the correct alignment of the methoxy (-OCH3) group and the aldehyde group at positions 2 and 3. This is essential for the subsequent synthesis of berberine, as the alkaloid structure of berberine depends on this specific substitution pattern.

[0017] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the aldehyde donor includes at least one of methyl formate, ethyl formate, and N,N-dimethylformamide.

[0018] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the molar ratio of 2,3-dimethoxyphenyl lithium to the aldehyde donor in step S2 is 1:(0.5-2.0).

[0019] In the above-mentioned method for synthesizing 2,3-dimethoxybenzaldehyde, the acid used in the acidification and neutralization process includes at least one of hydrochloric acid, sulfuric acid, phosphoric acid, and nitric acid.

[0020] This invention employs an acidification and neutralization step to quench the extraction reaction. However, because the reaction system contains highly reactive organolithium intermediates and some unreacted strong alkaline reagents, directly proceeding to subsequent separation and purification steps may trigger side reactions, affecting product purity and yield, and even posing safety hazards. Quenching with acidic reagents such as hydrochloric acid, sulfuric acid, phosphoric acid, or nitric acid effectively neutralizes the alkaline substances in the system, quickly terminating unnecessary chemical reactions. Simultaneously, it converts the reactive intermediates into stable 2,3-dimethoxybenzaldehyde molecules, preventing further decomposition or side reactions. Furthermore, the quenching reaction helps reduce the reactivity of the reaction mixture, improving operational safety and simplifying subsequent separation and purification processes, thereby enhancing the overall stability and feasibility of the process.

[0021] The present invention also provides 2,3-dimethoxybenzaldehyde, which is synthesized by the above method, with a yield of ≥95% and a purity of ≥99%.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. This invention provides a highly efficient, green, and low-cost method for synthesizing 2,3-dimethoxybenzaldehyde, with significant technical advantages and application prospects. Firstly, by optimizing the reaction pathway and conditions, this method effectively improves the yield and purity of the product. Experimental data shows that the yield of the target product, 2,3-dimethoxybenzaldehyde, can reach a high level, and the purity meets industrial application standards, greatly enhancing the utilization rate of raw materials and the market competitiveness of the product. Secondly, the process is simple, with few operating steps and a short reaction cycle, significantly reducing time costs and energy consumption during production, which is conducive to achieving large-scale, continuous production.

[0024] 2. This invention excels in environmental friendliness. It eliminates toxic and harmful reagents such as dimethyl sulfate and chloroform commonly used in traditional processes, replacing them with more environmentally friendly organic solvents and a milder reaction system, significantly reducing environmental pollution and threats to operator health. Furthermore, the method utilizes recyclable organic lithium reagents, further improving atom economy and reducing waste generation, aligning with current trends in green chemistry.

[0025] 3. The synthesis method of this invention has strong applicability. Reaction parameters such as the molar ratio of phthalic acid to butyllithium, reaction temperature, solvent type, and acidifying reagent selection can be flexibly adjusted, facilitating optimization and control according to actual production needs and enhancing the adaptability and stability of the process. This invention not only solves the problems of complex reaction steps, low yield, and significant environmental pollution in existing technologies, but also provides a feasible new route for the large-scale green preparation of 2,3-dimethoxybenzaldehyde, possessing good industrialization and promotion value and playing an important role in promoting the sustainable development of berberine and related pharmaceutical intermediates industries. Detailed Implementation

[0026] The following are specific embodiments of the present invention, which further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0027] The terms “comprising,” “including,” “having,” “containing,” or any other variations thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, or article that includes the listed elements is not necessarily limited to those elements, but may include other elements not expressly listed or elements inherent to such composition, step, method, or article.

[0028] The terms "one embodiment," "some embodiments," "example," "specific example," or "some examples" used in this invention refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms are not necessarily directed at the same embodiment or example. Furthermore, the technical features involved in the various embodiments of the invention can be combined with each other as long as they do not conflict with each other.

[0029] This invention provides a method for synthesizing 2,3-dimethoxybenzaldehyde, the method comprising the following steps:

[0030] S1. A nucleophilic substitution reaction was carried out between o-phenylenedimethyl ether and butyllithium in an organic solvent to give 2,3-dimethoxyphenyllithium;

[0031] S2. 2,3-Dimethoxyphenyllithium is subjected to a formylation reaction, and finally neutralized by acidification to obtain 2,3-dimethoxybenzaldehyde.

[0032] The main reaction formulas involved in the synthesis method of this invention are shown below, where M represents the relative molecular mass:

[0033]

[0034] Butyllithium is synthesized via the following reaction, where M represents the relative molecular mass:

[0035]

[0036] The method for synthesizing 2,3-dimethoxybenzaldehyde of the present invention will be further described in detail below through specific embodiments.

[0037] Example 1:

[0038] S1, Butyllithium Hydrogen Deposition: 60g of o-phthalic ether and 360g of methyl tert-butyl ether were added sequentially to a 1000ml dry reaction flask and stirred until dissolved. Nitrogen gas was used to purge the solution 2-3 times. The mixture was then cooled to -5℃. Butyllithium was rapidly added dropwise to the reaction system at a molar ratio of o-phthalic ether: butyllithium = 1:1.2. The temperature was controlled by freezing. After the addition was complete and the temperature stabilized, the freezing liquid was switched to -5℃ and the reaction was maintained for 12 hours to obtain 2,3-dimethoxyphenyllithium.

[0039] Phenomenon: The system became cloudy as butyllithium was added. The color was grayish-white immediately after the addition, and then turned milky white. The solid part on the bottle wall was yellowish.

[0040] S2, Formylation reaction: After the above reaction solution is kept at a constant temperature, the temperature is controlled at -5℃. N,N-Dimethylformamide is added dropwise at a molar ratio of 2,3-dimethoxyphenyllithium:N,N-dimethylformamide = 1:1.5 over 3 hours. After the addition is complete, the reaction is kept at a constant temperature for 1 hour.

[0041] Phenomenon: The reaction does not change much during the addition process. The solid part on the bottle wall is pink. If the temperature is too high, the reaction solution will be light red.

[0042] S3. Add 260 g of 15 wt% hydrochloric acid dropwise to the above reaction solution to obtain an organic layer. After concentrating the organic layer, 2,3-dimethoxybenzaldehyde is obtained.

[0043] Example 2:

[0044] S1, Butyllithium Hydrogen Desorption: 60g of o-phthalic ether and 360g of methyl tert-butyl ether were added sequentially to a 1000ml dry reaction flask and stirred until dissolved. Nitrogen gas was used to purge the solution 2-3 times. The mixture was then cooled to 0℃. Butyllithium was rapidly added dropwise to the reaction system at a molar ratio of o-phthalic ether: butyllithium = 1:0.5 over 4 minutes. The temperature was controlled by freezing. After the addition was complete and the temperature stabilized, the freezing solution was switched to 0℃ and the reaction was maintained at 0℃ for 24 hours to obtain 2,3-dimethoxyphenyllithium.

[0045] S2, Formylation reaction: After the above reaction solution is kept at a constant temperature, the temperature is controlled at -5℃. N,N-Dimethylformamide is added dropwise at a molar ratio of 2,3-dimethoxyphenyllithium:N,N-dimethylformamide = 1:1.5 over 3 hours. After the addition is complete, the reaction is kept at a constant temperature for 1 hour.

[0046] S3. 135 g of 15 wt% hydrochloric acid was added dropwise to the above reaction solution to obtain an organic layer. After concentrating the organic layer, 2,3-dimethoxybenzaldehyde was obtained.

[0047] Example 3:

[0048] S1, Butyllithium Hydrogen Desorption: 60g of o-phthalic ether and 360g of methyl tert-butyl ether were added sequentially to a 1000ml dry reaction flask and stirred until dissolved. Nitrogen gas was used to purge the solution 2-3 times. The mixture was then cooled to 2℃. Butyllithium was rapidly added dropwise to the reaction system at a molar ratio of o-phthalic ether: butyllithium = 1:1.5 over a period of 4 minutes. The temperature was controlled by freezing. After the addition was complete and the temperature stabilized, the solution was switched to a coolant and the reaction was maintained at 2℃ for 24 hours to obtain 2,3-dimethoxyphenyllithium.

[0049] S2, Formylation reaction: After the above reaction solution is kept at a constant temperature, it is frozen and cooled to -5℃. The temperature is controlled at -5℃. N,N-Dimethylformamide is added dropwise at a molar ratio of 2,3-dimethoxyphenyllithium:N,N-dimethylformamide = 1:1.5. The addition time is 3 hours. After the addition is completed, the reaction is kept at a constant temperature for 1 hour.

[0050] S3. Add 325 g of 15 wt% hydrochloric acid dropwise to the above reaction solution to obtain an organic layer. After concentrating the organic layer, 2,3-dimethoxybenzaldehyde is obtained.

[0051] Example 4:

[0052] S1, Butyllithium Hydrogen Deposition: 60g of o-phthalic ether and 360g of methyl tert-butyl ether were added sequentially to a 1000ml dry reaction flask and stirred until dissolved. Nitrogen gas was used to purge the solution 2-3 times. The mixture was then cooled to -5℃. Butyllithium was rapidly added dropwise to the reaction system at a molar ratio of o-phthalic ether: butyllithium = 1:0.8 over 4 minutes. The temperature was controlled by freezing. After the addition was complete and the temperature stabilized, the freezing solution was switched to -5℃ and the reaction was maintained for 12 hours to obtain 2,3-dimethoxyphenyllithium.

[0053] S2, Formylation reaction: After the above reaction solution is kept at a constant temperature, it is frozen and cooled to -5℃. The temperature is controlled at -5℃. N,N-Dimethylformamide is added dropwise at a molar ratio of 2,3-dimethoxyphenyllithium:N,N-dimethylformamide = 1:1.5. The addition time is 3 hours. After the addition is completed, the reaction is kept at a constant temperature for 1 hour.

[0054] S3. 173 g of 15 wt% hydrochloric acid was added dropwise to the above reaction solution to obtain an organic layer. After concentrating the organic layer, 2,3-dimethoxybenzaldehyde was obtained.

[0055] Example 5:

[0056] S1, Butyllithium Hydrogen Deposition: 60g of o-phthalic ether and 360g of methyl tert-butyl ether were added sequentially to a 1000ml dry reaction flask and stirred until dissolved. Nitrogen gas was used to purge the solution 2-3 times. The mixture was then cooled to -5℃. Butyllithium was rapidly added dropwise to the reaction system at a molar ratio of o-phthalic ether: butyllithium = 1:2.5 over 4 minutes. The temperature was controlled with liquid nitrogen. After the addition was complete and the temperature stabilized, the mixture was kept at -5℃ for 12 hours to obtain 2,3-dimethoxyphenyllithium.

[0057] S2, Formylation reaction: After the above reaction solution is kept at a constant temperature, it is frozen and cooled to -5℃. The temperature is controlled at -5℃. N,N-Dimethylformamide is added dropwise at a molar ratio of 2,3-dimethoxyphenyllithium:N,N-dimethylformamide = 1:1.5. The addition time is 3 hours. After the addition is completed, the reaction is kept at a constant temperature for 1 hour.

[0058] S3. 540 g of 15 wt% hydrochloric acid was added dropwise to the above reaction solution to obtain an organic layer. After concentrating the organic layer, 2,3-dimethoxybenzaldehyde was obtained.

[0059] Example 6:

[0060] The only difference from Example 1 is that the temperature of the heat preservation reaction in step S1 is 35°C.

[0061] Example 7:

[0062] The only difference from Example 1 is that the temperature of the heat preservation reaction in step S2 is 35°C.

[0063] Example 8:

[0064] The only difference from Example 1 is that the molar ratio of 2,6-dimethoxyphenyllithium and N,N-dimethylformamide in step S2 is 1:0.1.

[0065] Comparative Example 1:

[0066] The only difference from Example 1 is that no acidification and neutralization reaction was performed.

[0067] Comparative Example 2:

[0068] Traditional synthetic route: using catechol as raw material, methylating it with dimethyl sulfate, and then achieving formylation via the Reimer-Tiemann reaction.

[0069] Table 1: Yield and purity test results of 2,3-dimethoxybenzaldehyde prepared in the examples and comparative examples

[0070] Example Yield % purity% Example 1 95.6 99.5 Example 2 92.8 95.6 Example 3 96.3 95.8 Example 4 9.8 9.9 Example 5 1.5 1.8 Example 6 75.4 75.3 Example 7 74.5 73.5 Example 8 9.5 9.7 Comparative Example 1 0 0 Comparative Example 2 67.5 97.5

[0071] In summary, the synthesis method of this invention is highly adaptable. Reaction parameters such as the molar ratio of phthalic acid to butyllithium, reaction temperature, solvent type, and acidifying reagent selection can all be flexibly adjusted, facilitating optimization and control based on actual production needs and enhancing the process's adaptability and stability. This invention not only solves the problems of complex reaction steps, low yield, and significant environmental pollution in existing technologies, but also provides a practical new route for the large-scale green preparation of 2,3-dimethoxybenzaldehyde, possessing significant industrialization potential and playing a crucial role in promoting the sustainable development of berberine and related pharmaceutical intermediates industries.

[0072] The embodiments described herein cover any points not exhaustively within the scope of the technical claims of this invention, as well as new technical solutions formed by equivalent substitutions of one or more technical features in the embodiments. These are all within the scope of the claims of this invention. Furthermore, in all listed or unlisted embodiments of this invention, each parameter in the same embodiment merely represents an instance (i.e., a feasible solution) of its technical solution, and there is no strict coordination or limitation relationship between the parameters. The parameters can be substituted for each other without violating axioms and the claims of this invention, unless otherwise stated.

[0073] The technical means disclosed in this invention are not limited to those described above, but also include technical solutions composed of any combination of the above technical features. The above descriptions are specific embodiments of this invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of this invention, and these improvements and modifications are also considered within the scope of protection of this invention.

[0074] The specific embodiments described herein are merely illustrative of the spirit of the invention. Those skilled in the art to which this invention pertains may make various modifications or additions to the described specific embodiments or use similar methods to substitute them, without departing from the spirit of the invention or exceeding the scope defined by the appended claims.

Claims

1. A method for synthesizing 2,3-dimethoxybenzaldehyde, characterized in that, The method includes the following steps: S1. 2,6-Dimethoxyphenyllithium is obtained by dehydrogenation reaction of dimethyl ether and butyllithium in an organic solvent. S2. 2,6-Dimethoxyphenyllithium is subjected to a formylation reaction, and finally neutralized by acidification to obtain 2,3-dimethoxybenzaldehyde.

2. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, In step S1, the molar ratio of phthalic acid ether to butyllithium is 1:(0.5-1.5).

3. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, The hydrogen removal reaction in step S1 is carried out at a temperature of -78℃ to 10℃ for 8 to 10 hours.

4. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, The organic solvent includes at least one of tetrahydrofuran, 2-methyltetrahydrofuran, and methyl tert-butyl ether.

5. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, The formylation reaction in step S2 is carried out at a temperature of -78℃ to 10℃ for a time of 0.5 to 1.5 hours.

6. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, In step S2, 2,6-dimethoxyphenyllithium undergoes a formylation reaction with an aldehyde donor.

7. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 6, characterized in that, The aldehyde donor includes at least one of methyl formate, ethyl formate, and N,N-dimethylformamide.

8. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 6, characterized in that, In step S2, the molar ratio of 2,6-dimethoxyphenyllithium to the aldehyde donor is 1:(0.5-2.0).

9. The method for synthesizing 2,3-dimethoxybenzaldehyde according to claim 1, characterized in that, The acid used in the acidification and neutralization process includes at least one of hydrochloric acid, sulfuric acid, and nitric acid.

10. A 2,3-dimethoxybenzaldehyde, characterized in that, The 2,3-dimethoxybenzaldehyde was synthesized by the method described in any one of claims 1-9, and the yield of the synthesized 2,3-dimethoxybenzaldehyde was ≥95%, and the purity was ≥99%.

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