Improved application moxibustion based on Mongolian moxibustion and preparation method thereof

Abstract

The invention provides application moxibustion based on Mongolian moxibustion improvement and a preparation method thereof, and relates to the technical field of Mongolian moxibustion, and the application moxibustion sequentially comprises an outer layer, a medicine layer, a heating layer and an isolation layer from outside to inside; wherein the outer layer is medical grade breathable gauze, and the edge of the inner side of the outer layer is coated with medical silica gel pressure-sensitive adhesive; the medicine layer is provided with Mongolian medicine nano-microcapsules, and the Mongolian medicine nano-microcapsules are prepared by adopting a liposome wrapping technology and comprise fennel, saffron crocus, radix aconiti agrestis, sea-buckthorn and musk; the heating layer comprises a composite heating agent of iron powder, activated carbon, salt and far infrared ceramic powder; the isolating layer is a temperature-sensitive color-changing gel film, and when the temperature exceeds 50 DEG C, red warning is shown. The traditional Mongolian moxibustion is improved by combining the modern material science, the slow release technology and the heating regulation and control technology, the application moxibustion which is free of smoke and open fire, accurate in temperature control, capable of achieving medicine slow release and convenient to operate is provided, the traditional essence of the Mongolian medicine is reserved, and the modern life requirements are met.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of Mongolian moxibustion, more particularly to a patch moxibustion based on improved Mongolian moxibustion and a preparation method thereof. BACKGROUND

[0002] Mongolian moxibustion is a traditional therapy with a long history in Mongolian medicine, and its core principle is to achieve the therapeutic effect of warming meridians and regulating blood circulation through "heat penetration + drug penetration". It is widely used in the fields of joint pain and cold syndrome conditioning.

[0003] However, traditional Mongolian moxibustion has many limitations in practical application. First of all, the operation safety is insufficient, relying on open fire to generate heat, which is easy to cause burns and requires professional operation, which is difficult for ordinary users to master. Secondly, the environmental adaptability is poor, and a large amount of smoke is generated during the burning process, which not only pollutes the environment but also may cause irritation to respiratory sensitive groups, and is not suitable for use in closed or public places such as homes and offices. Thirdly, the drug utilization rate is low, and the drugs are mostly directly applied or mixed and burned, and the effective components are easily destroyed or quickly lost due to high temperature, and cannot achieve sustained penetration. SUMMARY

[0004] To solve the above problems, the present application improves the traditional Mongolian moxibustion by combining modern material science, slow-release technology and heating regulation technology, and provides a smokeless and open fire-free patch moxibustion with precise temperature control, drug slow-release and convenient operation, which not only retains the traditional essence of Mongolian medicine but also meets the needs of modern life.

[0005] The first aspect of the present application provides a patch moxibustion based on improved Mongolian moxibustion, which comprises an outer layer, a drug layer, a heating layer and an isolation layer from outside to inside. The outer layer is a medical-grade air-permeable gauze, and the inner edge is coated with medical silicone pressure-sensitive adhesive. The drug layer has Mongolian medicine nano-microcapsules, which are prepared by liposome encapsulation technology, and the Mongolian medicine nano-microcapsules include fennel, saffron, radix aconiti, sea buckthorn and musk. The heating layer comprises a composite heating agent of iron powder, activated carbon, salt and far-infrared ceramic powder. The isolation layer is a temperature-sensitive color-changing gel film that turns red when the temperature exceeds 50℃.

[0006] Further, the particle size of the Mongolian medicine nano-microcapsules is 100-500nm, and the mass ratio of the liposome to the Mongolian medicine component is 1:(3-5).

[0007] Further, the mass ratio of each component in the composite heating agent is: iron powder 40-50%, activated carbon 20-25%, salt 5-10%, and far-infrared ceramic powder 15-25%.

[0008] Furthermore, the adhesive strength of the medical silicone pressure-sensitive adhesive is 5-10 N / cm², and the outer edge is provided with a tearable adjustment strip, which can be used to adjust the adhesion by increasing or decreasing the number of adjustment strips.

[0009] Furthermore, the color-changing threshold of the thermosensitive color-changing gel film is 50℃±1℃, and the color-changing duration is ≥30s.

[0010] Furthermore, the moxibustion patch is a pre-packaged patch, measuring 5cm × 7cm, which can be cut and is individually vacuum-packed.

[0011] The second aspect of this invention provides a method for preparing a modified Mongolian moxibustion patch, applicable to the preparation of the moxibustion patch described in the claim, comprising the following steps: S1. Preparation of drug layer: Take Mongolian medicine raw materials, crush them, and extract them three times with 70-80% ethanol. Combine the extracts and concentrate them into an extract. Mix the extract with the wall material at a mass ratio of 1:(2-3) and process it with a high-pressure homogenizer to obtain nanocapsules with a particle size of 100-500nm. Mix the nanocapsules with liposome solution at a mass ratio of 1:(3-5), stir and embed for 1-2 hours, and dry to obtain the drug layer material. S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 10-15%, stir evenly and press into a sheet with a thickness of 0.3-0.5cm. S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical-grade silicone pressure-sensitive adhesive with a thickness of 0.1-0.2mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack.

[0012] Furthermore, the wall material mentioned in step S1 is a gelatin-gum arabic compound, and the concentration of the liposome solution is 10-20 mg / mL.

[0013] Furthermore, the salt mentioned in step S2 is sodium chloride or potassium chloride, and the particle size of the far-infrared ceramic powder is 1-5 μm.

[0014] Furthermore, the sealing and fixing in step S4 is performed using ultrasonic welding at a temperature of 60-80°C for 1-2 seconds.

[0015] Compared with traditional Mongolian moxibustion, this invention has the following advantages: Enhanced safety: No open flame, no smoke, avoiding fire and smoke pollution; precise temperature control (40-50℃) combined with temperature-sensitive color-changing warning, completely eliminating the risk of burns.

[0016] Enhanced efficacy: Liposome encapsulation and nano-microencapsulation technology protect drug activity, providing sustained release for 6-8 hours, increasing drug utilization by more than 3 times compared to traditional single-dose penetration.

[0017] Easy to use: It can be used immediately after disassembly, without professional operation. The adhesive strength is adjustable to adapt to moving parts such as joints. It is suitable for various scenarios such as home, office and outdoors.

[0018] Preserving the essence of tradition: Through the synergistic effect of "heat penetration through acupoints + drug penetration", the traditional therapeutic effect of Mongolian moxibustion is maintained, while achieving modern improvements. Detailed Implementation

[0019] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0020] Unless otherwise stated, all raw materials used in the following examples are commercially available.

[0021] Example 1 A modified Mongolian moxibustion patch, comprising, from the outside to the inside, an outer layer, a drug layer, a heating layer, and an isolation layer; wherein: the outer layer is medical-grade breathable gauze, with its inner edge coated with medical-grade silicone pressure-sensitive adhesive; the drug layer contains Mongolian medicine nanocapsules, which are prepared using liposome encapsulation technology and include 20 parts fennel, 5 parts saffron, 10 parts aconite, 30 parts sea buckthorn, and 1 part musk; the heating layer comprises a composite heating agent consisting of iron powder, activated carbon, salts, and far-infrared ceramic powder; the isolation layer is a thermosensitive color-changing gel film that displays a red warning when the temperature exceeds 50°C.

[0022] The Mongolian medicine nanocapsules have a particle size of 500nm, and the mass ratio of liposomes to Mongolian medicine components is 1:3. The mass percentages of the components in the composite heating agent are: iron powder 40%, activated carbon 25%, salts 10%, and far-infrared ceramic powder 25%. The medical-grade silicone pressure-sensitive adhesive has an adhesion strength of 5N / cm², and the outer edge has a tear-away adjustment strip, allowing for adjustment of adhesion by increasing or decreasing the number of adjustment strips. The thermosensitive color-changing gel film has a color-changing threshold of 50℃±1℃ and a color-changing duration of ≥30s. The moxibustion patch is a pre-packaged patch, 5cm×7cm in size, which can be cut and is individually vacuum-packed.

[0023] Its preparation methods include: S1. Preparation of the drug layer: The Mongolian medicine raw material was pulverized and extracted three times with 70% ethanol. The extracts were combined and concentrated into an extract. The extract and wall material were mixed at a mass ratio of 1:2 and processed by a high-pressure homogenizer to obtain nanocapsules with a particle size of 500 nm. The nanocapsules and liposome solution were mixed at a mass ratio of 1:3, stirred and embedded for 1 h, and dried to obtain the drug layer material. The wall material was a gelatin-gum arabic compound, and the concentration of the liposome solution was 10 mg / mL.

[0024] S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts, and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 10%, stir evenly, and press into a sheet with a thickness of 0.3cm; the salts are sodium chloride or potassium chloride; the particle size of the far-infrared ceramic powder is 1μm; S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical-grade silicone pressure-sensitive adhesive with a thickness of 0.1-0.2mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer, and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack. The sealing and fixing are achieved using ultrasonic welding at 60℃ for 1 second.

[0025] Example 2 A modified Mongolian moxibustion patch, comprising, from the outside to the inside, an outer layer, a drug layer, a heating layer, and an isolation layer; wherein: the outer layer is medical-grade breathable gauze, with its inner edge coated with medical-grade silicone pressure-sensitive adhesive; the drug layer contains Mongolian medicine nanocapsules, which are prepared using liposome encapsulation technology and include 20 parts fennel, 5 parts saffron, 10 parts aconite, 30 parts sea buckthorn, and 1 part musk; the heating layer comprises a composite heating agent consisting of iron powder, activated carbon, salts, and far-infrared ceramic powder; the isolation layer is a thermosensitive color-changing gel film that displays a red warning when the temperature exceeds 50°C.

[0026] The Mongolian medicine nanocapsules have a particle size of 100nm, and the mass ratio of liposomes to Mongolian medicine components is 1:5. The mass percentages of the components in the composite heating agent are: 50% iron powder, 20% activated carbon, 8% salts, and 22% far-infrared ceramic powder. The medical-grade silicone pressure-sensitive adhesive has an adhesion strength of 7N / cm², and the outer edge has a tearable adjustment strip, allowing for adjustment of adhesion by increasing or decreasing the number of adjustment strips. The thermosensitive color-changing gel film has a color-changing threshold of 50℃±1℃ and a color-changing duration of ≥30s. The moxibustion patch is a pre-packaged patch, 5cm×7cm in size, which can be cut and is individually vacuum-packed.

[0027] Its preparation methods include: S1. Preparation of the drug layer: The Mongolian medicine raw material was pulverized and extracted three times with 80% ethanol. The extracts were combined and concentrated into an extract. The extract and wall material were mixed at a mass ratio of 1:3 and processed by a high-pressure homogenizer to obtain nanocapsules with a particle size of 100 nm. The nanocapsules and liposome solution were mixed at a mass ratio of 1:5, stirred and embedded for 2 h, and dried to obtain the drug layer material. The wall material was a gelatin-gum arabic compound, and the concentration of the liposome solution was 20 mg / mL.

[0028] S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts, and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 15%, stir evenly, and press into a sheet with a thickness of 0.5 cm; the salts are sodium chloride or potassium chloride; the particle size of the far-infrared ceramic powder is 5 μm; S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical silicone pressure-sensitive adhesive with a thickness of 0.2mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer, and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack. The sealing and fixing are achieved using ultrasonic welding at 80℃ for 2 seconds.

[0029] Example 3 A modified Mongolian moxibustion patch, comprising, from the outside to the inside, an outer layer, a drug layer, a heating layer, and an isolation layer; wherein: the outer layer is medical-grade breathable gauze, with its inner edge coated with medical-grade silicone pressure-sensitive adhesive; the drug layer contains Mongolian medicine nanocapsules, which are prepared using liposome encapsulation technology and include 20 parts fennel, 5 parts saffron, 10 parts aconite, 30 parts sea buckthorn, and 1 part musk; the heating layer comprises a composite heating agent consisting of iron powder, activated carbon, salts, and far-infrared ceramic powder; the isolation layer is a thermosensitive color-changing gel film that displays a red warning when the temperature exceeds 50°C.

[0030] The Mongolian medicine nanocapsules have a particle size of 200nm, and the mass ratio of liposomes to Mongolian medicine components is 1:4. The mass percentages of the components in the composite heating agent are: 50% iron powder, 25% activated carbon, 10% salts, and 15% far-infrared ceramic powder. The medical-grade silicone pressure-sensitive adhesive has an adhesion strength of 10N / cm², and the outer edge has a tearable adjustment strip, allowing for adjustment of adhesion by increasing or decreasing the number of adjustment strips. The thermosensitive color-changing gel film has a color-changing threshold of 50℃±1℃ and a color-changing duration of ≥30s. The moxibustion patch is a pre-packaged patch, 5cm×7cm in size, which can be cut and is individually vacuum-packed.

[0031] Its preparation methods include: S1. Preparation of the drug layer: The Mongolian medicine raw material was pulverized and extracted three times with 75% ethanol. The extracts were combined and concentrated into an extract. The extract was mixed with the wall material at a mass ratio of 1:2.5 and processed by a high-pressure homogenizer to obtain nanocapsules with a particle size of 200 nm. The nanocapsules were mixed with liposome solution at a mass ratio of 1:4, stirred and embedded for 1.5 h, and dried to obtain the drug layer material. The wall material was a gelatin-gum arabic compound, and the concentration of the liposome solution was 15 mg / mL.

[0032] S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts, and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 12%, stir evenly, and press into a sheet with a thickness of 0.4 cm; the salts are sodium chloride or potassium chloride; the particle size of the far-infrared ceramic powder is 3 μm; S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical silicone pressure-sensitive adhesive with a thickness of 0.15mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer, and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack. The sealing and fixing are done using ultrasonic welding at 70℃ for 1.5s.

[0033] Example 4 A modified Mongolian moxibustion patch, comprising, from the outside to the inside, an outer layer, a drug layer, a heating layer, and an isolation layer; wherein: the outer layer is medical-grade breathable gauze, with its inner edge coated with medical-grade silicone pressure-sensitive adhesive; the drug layer contains Mongolian medicine nanocapsules, which are prepared using liposome encapsulation technology and include 20 parts fennel, 5 parts saffron, 10 parts aconite, 30 parts sea buckthorn, and 1 part musk; the heating layer comprises a composite heating agent consisting of iron powder, activated carbon, salts, and far-infrared ceramic powder; the isolation layer is a thermosensitive color-changing gel film that displays a red warning when the temperature exceeds 50°C.

[0034] The Mongolian medicine nanocapsules have a particle size of 200nm, and the mass ratio of liposomes to Mongolian medicine components is 1:4. The mass percentages of the components in the composite heating agent are: iron powder 45%, activated carbon 22%, potassium chloride 8%, and far-infrared ceramic powder 25%. The medical-grade silicone pressure-sensitive adhesive has an adhesion strength of 10N / cm², and the outer edge has a tearable adjustment strip, allowing for adjustment of adhesion by increasing or decreasing the number of adjustment strips. The thermosensitive color-changing gel film has a color-changing threshold of 50℃±1℃ and a color-changing duration of ≥30s. The moxibustion patch is a pre-packaged patch, 5cm×7cm in size, which can be cut and is individually vacuum-packed.

[0035] Its preparation methods include: S1. Preparation of the drug layer: The Mongolian medicine raw material was pulverized and extracted three times with 75% ethanol. The extracts were combined and concentrated into an extract. The extract was mixed with the wall material at a mass ratio of 1:2.5 and processed by a high-pressure homogenizer to obtain nanocapsules with a particle size of 200 nm. The nanocapsules were mixed with liposome solution at a mass ratio of 1:4, stirred and embedded for 1.5 h, and dried to obtain the drug layer material. The wall material was a gelatin-gum arabic compound, and the concentration of the liposome solution was 15 mg / mL.

[0036] S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts, and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 12%, stir evenly, and press into a sheet with a thickness of 0.4 cm; the salts are sodium chloride or potassium chloride; the particle size of the far-infrared ceramic powder is 3 μm; S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical silicone pressure-sensitive adhesive with a thickness of 0.15mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer, and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack. The sealing and fixing are done using ultrasonic welding at 70℃ for 1.5s.

[0037] Comparative Example 1 The traditional Mongolian moxibustion method replaces the topical moxibustion in Example 4. Traditional Mongolian moxibustion uses flammable plant materials as its core, including a medicinal ball or bundle made of dried moxa wool, mugwort leaves, ephedra, and fennel. When used, the medicinal ball is directly ignited to generate heat, and the heat released during the combustion process is applied to the acupoints to achieve the effect of "heat penetrating the acupoints".

[0038] Comparative Example 2 Taking Example 4 as an example, compared with Example 4, the drug layer is directly composed of 20 parts of fennel, 5 parts of saffron, 10 parts of aconite, 30 parts of sea buckthorn and 1 part of musk.

[0039] Comparative Example 3 Taking Example 4 as an example, compared with Example 4, the heating layer is filled with an equal amount of activated carbon instead of potassium chloride, while the other components remain unchanged.

[0040] Comparative Example 4 Taking Example 4 as an example, compared with Example 4, the activated carbon in the heating layer is replaced with an equal amount of potassium chloride, while the other components remain unchanged.

[0041] How to use: Clean the skin at the application site; Tear open the vacuum packaging and remove the protective film from the patch; Apply the patch to the acupoint, and adjust the adhesion by adding or removing the adjustment strips as needed for the area. Observe the temperature. If the isolation layer turns red (indicating excessively high temperature), adjust its position or suspend its use immediately.

[0042] Experiments were conducted on the moxibustion patches used in Examples 1-4 and Comparative Examples 1-4. The core detection indicators and detection process are as follows: 1. Drug release performance (core advantage: sustained release achieved through nanocapsules + liposome encapsulation) Indicators: Cumulative release rate (8h), release duration (time when drug release is ≥80%).

[0043] Experimental Procedure: Using the dialysis bag method, each layer of moxibustion patch was dissolved in PBS buffer (at 37℃ and pH 7.4, simulating a body fluid environment), placed in a dialysis bag (molecular weight cutoff 8000-14000 Da), and then placed in a beaker containing 100 mL of PBS. The mixture was magnetically stirred (100 rpm). Samples of 5 mL were taken at 1, 2, 4, 6, 8, 12, and 24 hours (with the addition of an equal volume of fresh PBS). The concentration of crocin (a biomarker) was determined by HPLC, and the cumulative release rate and release duration were calculated.

[0044] 2. Heating performance (Core advantage: Stable temperature control achieved through composite heating agent) Indicators: Initial heating time (time from opening to reaching 38°C), maximum temperature, effective heating duration (time to maintain temperature between 38-50°C), and temperature fluctuation (the difference between the highest and lowest temperatures).

[0045] Experimental procedure: At 25℃ and 50% humidity, the moxibustion patch was applied to pigskin (simulating human skin). A thermocouple (accuracy ±0.1℃) was attached between the heating layer and the pigskin. A recorder was connected and monitored continuously for 24 hours, recording the above indicators.

[0046] 3. Safety (Core advantages: Temperature-sensitive color-changing warning + No open flame) Indicators: Temperature warning response time (time from exceeding 50°C to turning red), incidence of skin burns (8 hours after application).

[0047] Experimental procedure: ① Temperature warning: Overheating was simulated using a constant temperature heating plate, and the time from when the temperature reached 51℃ to when the isolation layer turned red was recorded; ② Skin burn: The moxibustion patch was applied to the hairless area on the back of SD rats (n=5), and the skin was observed for erythema and blisters after 8 hours. The incidence of burns was calculated.

[0048] 4. Adhesive performance (core advantage: adjustable adhesion) Indicators: 8-hour adhesive strength retention rate (percentage of initial adhesive strength), and peeling rate.

[0049] Experimental procedure: The initial adhesive strength was measured using a tensile testing machine. The sample was applied to the back of a rat for 8 hours and then removed. The adhesive strength was measured again, and the retention rate was calculated. The number of samples that fell off within 8 hours was recorded, and the detachment rate (number of detached samples / total number of samples × 100%) was calculated.

[0050] 5. Skin irritation (Core advantage: Nano-encapsulation reduces irritation) Indicator: Skin irritation score (0-4 points, 0 = no reaction, 4 = severe edema / erythema).

[0051] Experimental procedure: The product was applied to the back of SD rats for 8 hours. After removal, the skin reaction was observed at 24 hours and 48 hours. The skin reaction was scored according to the "Cosmetic Safety Technical Specifications" and the average value was taken.

[0052] The results are shown in Table 1.

[0053] Table 1

Claims

1. A modified moxibustion patch based on Mongolian moxibustion, characterized in that, The moxibustion patch comprises, from the outside in, an outer layer, a drug layer, a heating layer, and an insulating layer; wherein: The outer layer is medical-grade breathable gauze, and its inner edge is coated with medical-grade silicone pressure-sensitive adhesive. The drug layer contains Mongolian medicine nanocapsules, which are prepared using liposome encapsulation technology and include fennel, saffron, aconite, sea buckthorn, and musk. The heating layer comprises a composite heating agent consisting of iron powder, activated carbon, salts, and far-infrared ceramic powder; The isolation layer is a thermosensitive color-changing gel film that displays a red warning when the temperature exceeds 50°C.

2. The moxibustion patch according to claim 1, characterized in that, The particle size of the Mongolian medicine nanocapsules is 100-500 nm, and the mass ratio of the liposomes to the Mongolian medicine components is 1:(3-5).

3. The moxibustion patch according to claim 1, characterized in that, The mass percentages of each component in the composite heating agent are as follows: 40-50% iron powder, 20-25% activated carbon, 5-10% salts, and 15-25% far-infrared ceramic powder.

4. The moxibustion patch according to claim 1, characterized in that, The adhesive strength of the medical silicone pressure-sensitive adhesive is 5-10 N / cm², and the outer edge is provided with a tearable adjustment strip, which can be adjusted by increasing or decreasing the number of adjustment strips.

5. The moxibustion patch according to claim 1, characterized in that, The color-changing threshold of the thermosensitive color-changing gel film is 50℃±1℃, and the color-changing duration is ≥30s.

6. The moxibustion patch according to claim 1, characterized in that, The moxibustion patch is a pre-packaged patch, measuring 5cm × 7cm, which can be cut and is individually vacuum-packed.

7. A method for preparing a modified Mongolian moxibustion patch, used in the preparation of the moxibustion patch according to any one of claims 1-6, characterized in that, Includes the following steps: S1. Preparation of drug layer: Take Mongolian medicine raw materials, crush them, and extract them three times with 70-80% ethanol. Combine the extracts and concentrate them into an extract. Mix the extract with the wall material at a mass ratio of 1:(2-3) and process it with a high-pressure homogenizer to obtain nanocapsules with a particle size of 100-500nm. Mix the nanocapsules with liposome solution at a mass ratio of 1:(3-5), stir and embed for 1-2 hours, and dry to obtain the drug layer material. S2. Preparation of heating layer: Weigh iron powder, activated carbon, salts and far-infrared ceramic powder according to the mass ratio, mix them, add deionized water to adjust the humidity to 10-15%, stir evenly and press into a sheet with a thickness of 0.3-0.5cm. S3. Preparation of outer layer: Take medical-grade breathable gauze, coat its inner edge with medical-grade silicone pressure-sensitive adhesive with a thickness of 0.1-0.2mm, and after drying, add a tear-off adjustment strip to the edge; S4. Assembly: Stack the isolation layer, heating layer, drug layer and outer layer in sequence, seal and fix the edges, cut into 5cm×7cm patches, and vacuum pack.

8. The preparation method according to claim 7, characterized in that, The wall material mentioned in step S1 is a gelatin-gum arabic compound, and the concentration of the liposome solution is 10-20 mg / mL.

9. The preparation method according to claim 7, characterized in that, The salt mentioned in step S2 is sodium chloride or potassium chloride, and the particle size of the far-infrared ceramic powder is 1-5 μm.

10. The preparation method according to claim 7, characterized in that, The sealing and fixing in step S4 is achieved by ultrasonic welding at a temperature of 60-80℃ for 1-2 seconds.

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