Ampoule bottle for medical liquids, in particular ophthalmic liquids

Abstract

The invention relates to an ampoule bottle (10) for a medical liquid, in particular an ophthalmic liquid, comprising: a bottle body (5) for containing a medical liquid; the foot part (6) is used for arranging a label (9), and the foot part (6) is connected to the bottle body (5) below the bottle body; the shoulder part (4) is connected to the bottle body (5) above the bottle body; a neck part (3) which is connected to the shoulder part (4) above the shoulder part; a head (2), which is connected to the neck (3) above the neck, with an applicator opening (2a) for removing the medical liquid from the ampoule bottle (10); and a screw-discarding part (1) as a closure which, in the initial state of the ampoule bottle (10), is connected to the head part (2) through a predetermined breaking position (1a) and closes the applicator opening (2a) in a liquid-tight manner. The ampoule bottle is characterized in that the head (2) is designed as a truncated spheroid, preferably as a truncated sphere, having at least one upper base surface in which the applicator opening (2a) is located.

Description

TECHNICAL FIELD

[0001] The present invention relates to an ampoule for medical liquids, in particular ophthalmic liquids, according to the preamble of claim 1. BACKGROUND

[0002] Ampoules are used for storing, preparing and / or transporting medical liquids and can be provided in different sizes, for example with a capacity of between 5 ml and 30 ml. The medical liquids contained in such ampoules can be, for example, medical substances, such as pharmaceuticals, or other liquids for medical purposes. Such ampoules generally comprise an ampoule body for containing the medical liquid and a discard part or screw-off discard part which, in the initial state, closes an opening through which the liquid is withdrawn.

[0003] Conventional ampoules are manufactured using the so-called blow-fill-seal (BFS) method. The blow-fill-seal method is a method which is used in particular for manufacturing containers for containing liquids. In the blow-fill-seal method, the containers are formed, filled and sealed in a continuous process in a closed environment within a machine without the need for operator intervention. In the blow-fill-seal method, a plastic material is extruded vertically to produce a tubular section, which is then formed and filled in a mould and finally sealed. Due to the shape of the containers, the blow-fill-seal method is particularly suitable for producing ampoules for containing medical liquids, in particular in a sterile environment.

[0004] Ampoules are also used in ophthalmology. In this case, the capacity of the ampoules is generally small, for example between 0.1 ml and 5 ml. The ampoules contain a medical liquid or solution which is applied into the eye. In this case, the ampoules are generally used as a single-use or single-dose applicator. The liquid is generally a sodium chloride solution or an emulsion which contains or can contain a pharmaceutical for treating an eye disease. In some cases, the liquid can not contain a pharmaceutical, but instead is used only as a lubricant and / or tear substitute. The document EP 3 471 685 B1 describes an example of such an ampoule. Only an applicator tip with a blunted tip is described in the document as an example, the advantage of which is to avoid scratching the cornea of the patient when administering.

[0005] There is a need for an ampoule for ophthalmic applications which reduces the risk of eye damage when administering and which enables improved dosing. SUMMARY

[0006] The present invention therefore addresses in particular the technical problem of providing an ampoule for ophthalmic applications which reduces the risk of eye damage when administering and which enables improved dosing.

[0007] This technical problem is solved by the subject matter with the features according to the independent claims. The subject matter of the description, the figures and the dependent claims are preferred embodiments.

[0008] The application is generally described by an ampoule, which comprises in particular an improved head geometry, which comprises a dispenser opening The liquid to be taken out is taken out through the dispenser opening. According to the application, the head is designed as an ellipsoid section, preferably as a spherical section, with at least one upper base surface, in which the dispenser opening is located. Thereby, an improved dosing or defined droplet formation can be achieved, wherein at the same time a blunt surface of the ampoule is formed, so that the risk of eye injuries during administration is reduced.

[0009] The application is described in detail by an ampoule for medical liquids, in particular for ophthalmic liquids, which comprises a body for containing a medical liquid, a shoulder connected to the body above the body, a neck connected to the shoulder above the shoulder, a head connected to the neck above the neck with a dispenser opening for taking out the medical liquid from the ampoule, and a twist-off portion as a closure, which in the initial state of the ampoule is connected to the head by a predetermined breaking point and closes the dispenser opening in a liquid-tight manner. According to the application or preferably, the head is designed as an ellipsoid section, preferably as a spherical section, with at least one upper base surface, in which the dispenser opening is located. The ampoule is preferably an eye drop ampoule.

[0010] According to the application, or in particular, the head is designed as an ellipsoid section, preferably as a spherical section, with at least one upper base surface, in which the dispenser opening is located, and with a cross section that increases from the neck and / or decreases towards the direction of the dispenser opening. The head preferably has a convexity. Preferably, the inner space of the neck is delimited by the curved wall of the ellipsoid section or the spherical section. In one configuration, the head is designed as a hollow spherical ring, wherein the wall of the head is provided or formed by the spherical layer of the spherical ring.

[0011] The twist-off portion provides a tamper-evident closure for the ampoule. In one preferred embodiment, the twist-off portion is arranged completely above the head and is connected to the head only by a predetermined breaking point, preferably annular. Thereby, a defined twist-off behavior is achieved with a predetermined geometry of the predetermined breaking point. Furthermore, the number of edges and / or burrs after removal or twist-off of the twist-off portion is reduced.

[0012] The predetermined breaking point is preferably located in the upper base face of the truncated ellipsoid, preferably a truncated sphere. After removal of the screw-off discard, this base face is provided as a flat base face, wherein the dispenser opening is delimited by a surrounding flat circular ring, which provides the predetermined breaking point.

[0013] In one configuration, the screw-off discard is provided with a grip on at least one side, preferably on both sides, with a flat resting surface and a resting edge for the fingertips. The screw-off discard preferably comprises a cap or closure cap, which in the initial state closes the dispenser opening. The closure cap forms the lower side of the screw-off discard and is formed integrally with the grip. The grip extends around the cap and provides a lever for removing the screw-off discard.

[0014] In one embodiment, the truncated ellipsoid, preferably a truncated sphere, comprises not only an upper base face, but also a lower base face. Thereby, a defined transition to the neck can be provided.

[0015] In one configuration, the diameter of the truncated ellipsoid, preferably a truncated sphere, is 4 mm to 7 mm, preferably 5 mm. Thereby, a defined amount of droplet spheres for ophthalmic applications can be achieved. The head preferably provides a volume of 0.3 ml to 0.5 ml to be fed through the dispenser opening.

[0016] In one configuration, the neck has a cross section that tapers in the direction of the head from the shoulder. In another configuration, the cross section of the shoulder also tapers in the direction of the neck from the bottle body. Thereby, the neck and the shoulder together form a funnel or funnel form. With this, the outflow behavior of the liquid can be improved.

[0017] In a preferred embodiment, the ampoule further comprises a foot for arranging a label, wherein the foot is connected to the bottle body below. The foot can have a constant cross section. A label, for example with product information, is preferably affixed on the foot.

[0018] In another configuration of the ampoule, the cross section of the bottle body tapers in the direction of the foot from the shoulder. Alternatively, the bottle body can also have a substantially uniform cross section. Preferably, a company logo is arranged, preferably embossed, on at least the wall of the bottle body and / or, if necessary, product information is also arranged, preferably embossed.

[0019] Preferably, the ampoule is a single-dose dispenser. In one configuration, the ampoule is designed to contain a volume of 0.1 ml to 3.0 ml, preferably a volume of 0.3 ml to 2.0 ml, preferably a volume of 0.8 ml to 1.5 ml.

[0020] The ampoule is manufactured by the blow-fill-seal technique (BFS) and is preferably formed integrally. Suitable materials for the ampoule include PE (polyethylene) and / or PP (polypropylene).

[0021] The shape and size of the ampoule is formed by the shape and size of the die machine. The present application therefore also comprises a BFS (blow-fill-seal) apparatus comprising an extruder and a die machine with a die, wherein the die comprises at least one cavity for forming an ampoule according to the present application.

[0022] In an ampoule assembly with a plurality of ampoules, the ampoules are preferably integrally connected to each other by connecting tabs. Here, one connecting tab is provided between each two ampoules. Here, two further ampoules can be arranged on each side of each ampoule, such that two diametrically opposed connecting tabs can be arranged on each ampoule, by means of which connecting tabs the further ampoules are joined to the ampoule body of the ampoule on both sides of the ampoule. The present application therefore also comprises an ampoule assembly with at least two ampoules, wherein the at least two ampoules are integrally connected to each other by connecting tabs. BRIEF DESCRIPTION OF DRAWINGS

[0023] The present application will be explained in detail in accordance with the following examples. For this purpose, reference is made to the drawings and to the schematic illustrations thereof. Identical reference numerals in the various figures denote identical parts.

[0024] Fig. 1.a to Fig. 1.c show an embodiment of an ampoule according to the present application in a closed initial state in a perspective view (Fig. 1.a), in a front view (Fig. 1.b) and in a side view (Fig. 1.c), respectively;

[0025] Fig. 2.a to Fig. 2.c show an embodiment of an ampoule according to the present application with a removed twist-off portion in a perspective view (Fig. 2.a), in a front view (Fig. 2.b) and in a side view (Fig. 2.c), respectively;

[0026] Figure 3 An embodiment of an ampoule according to the present application is shown in a perspective view, the ampoule being in a state of use without a twist-off portion;

[0027] Fig. 4.a to 4.c show an embodiment of a tool according to the present application in a front view (Fig. 4.a), in a side view (Fig. 4.b) and in a bottom view (Fig. 4.c), respectively, the ampoule being in a closed initial state and having dimensions;

[0028] Figure 5 An embodiment of an ampoule assembly according to the present application is shown, the ampoule assembly having a plurality of ampoules which are integrally connected to each other by connecting tabs, respectively;

[0029] Figure 6 An embodiment of an ampoule assembly is shown after leaving the die machine. DETAILED DESCRIPTION

[0030] Figures la to lcAn embodiment of the ampoule 10 of the present invention in its initial closed state is shown, i.e., in the state after production and before use. The closure 1, which is designed here as a screw-on disposal part, is still firmly connected to the ampoule body and other components of the ampoule 10.

[0031] Ampoule 10 is an eye drop ampoule. Therefore, the medical fluid contained therein is an ophthalmic fluid or solution. Any fluid intended for use in the eye is considered an ophthalmic solution. The fluid is typically a base solution or emulsion that contains or may contain medications for treating eye conditions. In some cases, the fluid may not contain medication and may be used solely as a lubricant and / or tear substitute.

[0032] The ampoule 10 is preferably designed as a single-use delivery device. Once it has been opened by removing, unscrewing, or tearing open the screw-on disposal part 1, the ampoule 10 cannot be resealed.

[0033] The capacity of the ampoule 10 can also be selected so that only a single dose can be dispensed. In this configuration, the ampoule 10 is a single-dose delivery device. For example, the eye drop ampoule 10 is designed to hold a volume of 0.8 ml to 1.5 ml.

[0034] Ampoule 10 is manufactured using BFS (Browser-Free System). The materials used to manufacture ampoule 10 preferably include PE and / or PP. The eye drop ampoule 10 is integrally formed. Ampoule 10 is substantially mirror-symmetrical and is defined by a plane defined by axes h and b.

[0035] The illustrated ampoule 10 includes a body 5 for containing medical fluid. A foot 6 for attaching a label 9 is attached below the body 5 (see Figure 4.a). A shoulder 4 is attached to the body 5 above the shoulder. A neck 3 is attached to the shoulder 4 above the shoulder. The dispensing or administration portion of the ampoule 10 is formed by a head 2 attached to the neck 3 above the neck. The head 2 provides a delivery opening 2a (see Figure 4.a). Figures 2a to 3 ), for use in removing medical liquid from ampoule 10.

[0036] In its initial state, the applicator opening 2a is closed by a cap 1d. The cap 1d is part of the so-called screw-on discard section 1, which can be removed from the head 2 by tearing or unscrewing to use the ampoule 10. The screw-on discard section 1 is connected to the head 2 via a predetermined break point 1a. In the example shown, only the cap 1d of the screw-on discard section has the predetermined break point. In its initial state, the applicator opening 2a is sealed in a liquid-tight manner by means of or through the screw-on discard section 1. Specifically, only the cap 1d of the screw-on discard section 1 closes the applicator opening 2a. The screw-on discard section 1 provides an original seal identification closure function. The plate-shaped portion of the screw-on discard section 1 extends substantially within a plane defined by the width axis b and the height axis h.

[0037] The screw-on disposal part 1 is provided with grips on both sides, the grips having a flat resting surface 1a and a resting edge 1c for fingertips. This allows the screw-on disposal part 1 to be firmly gripped, for example, with the thumb and forefinger, and removed from the ampoule 10 by twisting. The grips are integrally formed with the cap 1d. The grips extend downwards on both sides in a columnar form around the cap 1d. The screw-on disposal part 1 is preferably positioned entirely above the head 2. The screw-on disposal part 1 extends only above the head 2. The screw-on disposal part 1 does not extend axially along the sides of the head 2. The screw-on disposal part 1 is connected to the upper side of the head 2 only through its lower side. Specifically, the screw-on disposal part 1 is connected to the upper side of the head 2 only through its cap 1d. The screw-on disposal part 1, particularly its cap 1d, is connected to the head 2 through a preferably annular predetermined break point 1a. The head 2 is not part of the screw-on disposal part 1.

[0038] The head 2 is designed as a truncated sphere with at least one upper bottom surface, which provides the administration device opening 2a. The predetermined fracture location 1a is located within the upper bottom surface of the truncated sphere and is designed to be annular. Further details regarding the head 2 will be provided in conjunction with... Figures 2a to 3 explain.

[0039] The head 2 transitions specifically to an axially extending neck 3 via a step (e.g., an edge), which connects the bottle body 5 to the head 2 via a shoulder 4. In the illustrated example, the cross-section of the neck 3 tapers from the shoulder 4 toward the head 2. The neck 3 is a tube whose cross-section increases downwards.

[0040] The neck 3 transitions downwards to the shoulder 4. The cross-section of the ampoule 10 widens in the shoulder region via a step (e.g., an edge or rounded corner). Compared to the wall of the neck 3, the wall of the shoulder 4 has a smaller inclination relative to the longitudinal axis of the ampoule 10. Therefore, the cross-sectional area of ​​the shoulder 4 increases significantly from the neck 3 towards the body 3. Conversely, the cross-sectional area of ​​the shoulder 4 decreases from the body 5 towards the neck 2.

[0041] The neck 3 and shoulder 4 together form a funnel shape. The funnel-shaped design of the neck 3 and shoulder 4 has a positive impact on the outflow characteristics of the liquid leaving the ampoule.

[0042] The cross-sectional area of ​​the bottle body 5 decreases from the shoulder 4 towards the bottom 6. At least the width (along axis b) of the bottle body 5 of the ampoule 10 is greater than its depth (along axis t). This is particularly evident by comparing Figures 1.b and 1.c. This also applies here particularly to the screw-on disposal part 1, the neck 2, and the foot 6. Thus, the ampoule 10 can be securely held during use, and the bottle body 5 can be compressed in a prescribed manner to apply medical fluid into the eye. Here, a company mark or logo is arranged on the wall of the bottle body 5, preferably embossed during manufacturing.

[0043] The foot 6 connects to the bottle body 5 below the bottle body. The lower side of the foot 6 forms the lower side of the ampoule 10. The foot 6 is the tail (Schwanz) connected to the bottle body 5. The foot 6 is constructed as a plate. For example, the foot 6 is made of rectangle. The foot 6 has a uniform width in the plane defined by axes h and b, and a uniform depth in the plane defined by axes h and t. For example, a label 9 preferably containing product information (see Figure 4.a) can be affixed to the foot 6.

[0044] Figures 2a to 3 An embodiment of the ampoule 10 according to the invention is shown, wherein the screw-on discard part 1 has been removed. The head 2 with the administration opening 2a according to the invention is particularly visible.

[0045] Typically, the ampoules can be conceived such that the head 2 is designed as a truncated ellipsoid with at least one upper base surface providing a drug delivery opening 2a. In the illustrated embodiment, the head 2 is substantially rotationally symmetrical. Here, the head 2 is designed as a truncated sphere with at least one upper base surface providing a drug delivery opening 2a.

[0046] After removing the screw-on discard part 1, a flat bottom surface is provided, wherein the drug delivery device opening 2a is defined by a flat ring surrounding it. The ring preferably forms the area of ​​the predetermined breakage position 1a.

[0047] Here, the head 2 has a cross-section that first increases upward from the neck 3 and then decreases again. This creates a protrusion within the head 2. The head 2 has a protrusion. The head 2 is situated on the neck 3 in the form of a sphere, wherein the upper and / or lower caps of the sphere are removed.

[0048] The truncated sphere of head 2 may have only an upper base surface and be completely spherical towards neck 3. In the illustrated embodiment, the truncated sphere has an upper base surface and a lower base surface to provide a transition to neck 3. Thus, head 2 has a spherical ring structure in its appearance. However, preferably, the internal volume formed within head 2 is not cylindrical, but spherical or at least partially earth-shaped. The internal volume or internal space of head 2 is here formed substantially entirely by the curved walls of head 2. The shape of the internal space of head 2 substantially corresponds to the shape of the walls of head 2. The head is designed as a hollow spherical ring. In the external construction of the spherical ring, the internal space of head 2 is defined or formed by the spherical layer that provides the walls.

[0049] The special construction of the head 2, particularly its connection with the screw-on dispensing part 1, enables precise dispensing of eye drops and reduces the risk of injury to the user during administration. The droplet sphere preferably provides a 0.3 ml to 0.5 ml droplet to be dispensed through the applicator opening.

[0050] As described above, the predetermined fracture location 1a is located within the upper bottom surface of the truncated sphere. The predetermined fracture location 1a is defined here by an annulus surrounding the drug delivery device opening 2a.

[0051] Figures 4.a to 4.c again illustrate the ampoule according to the invention in its initial closed state, but now with dimensions and a label 9 attached, in particular, to the foot 6. The dimensions are listed below. These dimensions may be individual or may be combined to form a complete set:

[0052] - The total height of the ampoule 10 is 40 mm to 60 mm, and / or the maximum width is 17 mm to 27 mm, preferably 22 mm, and / or the maximum depth is 5.4 mm to 9.4 mm, preferably 7.4 mm.

[0053] - The height of the screw-on discard part 1 is 10.5 mm to 20.5 mm, preferably 15.5 mm; and / or the width is 8.5 mm to 12.5 mm, preferably 10.5 mm; and / or the depth of the plate part is 1.6 mm to 2.6 mm, preferably 2.1 mm; and / or the diameter of the closing cover 1d is 3.6 mm to 7.6 mm, preferably 5.6 mm.

[0054] - The diameter of the head 2 (especially the truncated sphere) is 4mm to 7mm, preferably 5mm.

[0055] - The radial height of the upper bottom surface of the truncated sphere of head 2 is 2mm.

[0056] - The total height of the head 2, neck 3, shoulder 4 and bottle body 5 is 19mm to 29mm, preferably 24mm.

[0057] - The opening angle of the bottle body 5 (along the width direction) is 0° to 15°, or greater than 0° to 15°, and / or the opening angle (along the depth direction) is 5° to 15°, preferably 10°.

[0058] - The width of the foot 6 is 13mm to 23mm, preferably 18mm, and / or the depth is 0.3mm to 1.4mm, preferably 0.4mm.

[0059] Figure 5 An embodiment of an ampoule assembly 100 according to the present invention is shown, wherein a plurality of ampoules 10 are arranged in a row. As an example, five ampoules 10 are arranged in a row here. The ampoules 10 are interconnected by connecting pieces 101.

[0060] at last, Figure 6An embodiment of the ampoule assembly is shown during manufacturing or after leaving the die-casting machine. The ampoule 10 is manufactured herein using a BFS device (not shown), which includes an extruder and a subsequent die-casting machine. The ampoule 10 is preferably manufactured continuously in the form of a conveyor belt 110.

[0061] For example, eight ampoules 10 are arranged in a row to form an ampoule assembly 100, the ampoules being connected to each other as one piece by connecting tabs 101 (not all connecting tabs are marked with reference numerals). Therefore, this molding machine includes a mold with eight cavities.

[0062] In addition, two more rows of ampoules 10 are arranged as an example here. The resulting array is embedded within a continuously operating conveyor belt 110. The ampoule assemblies 100 are preferably manufactured continuously and fed out via the conveyor belt 110. Arrows indicate the direction of the continuous conveyor belt 110. The individual ampoule assemblies 100 are then removed from the conveyor belt 110 (not shown in the figure).

[0063] Those skilled in the art will understand that the described embodiments are to be considered as examples. The invention is not limited thereto, but can be varied in many ways without departing from the spirit of the invention. Features of individual embodiments and features mentioned in the summary section of the specification can be interchanged or combined with each other.

[0064] List of reference numerals

[0065] 1. A closed part or a screw-on disposal unit or a screw-on disposal cover

[0066] 1a Predetermined fracture location or predetermined fracture edge

[0067] 1b is the surface for resting the fingers.

[0068] 1c is used for the finger resting edge.

[0069] 1d Sealed Cap

[0070] 2. Head

[0071] 2a. Apparatus opening

[0072] 3. Neck

[0073] 4. Shoulders

[0074] 5 Bottle body

[0075] 6. Foot or label area

[0076] 8. Corporate Logo

[0077] 9. Labels or product labels

[0078] 10 ampoules or eye drop ampoules

[0079] 100 Ampoule Components

[0080] 101 Connecting piece

[0081] 110 ampoule conveyor belt

Claims

1. An ampoule (10) for use with medical liquids, particularly ophthalmic liquids, comprising: - Bottle body (5) for containing medical liquids, - Shoulder (4), said shoulder (4) is connected to the bottle body (5) above the bottle body. - Neck (3), which connects to the shoulder (4) above the shoulder. - A head (2), which is attached to the neck (3) above the neck and has a delivery opening (2a) for removing the medical liquid from the ampoule (10), and - The screw-on discard part (1), as a closure component, is connected to the head (2) via a predetermined break position (1a) in the initial state of the ampoule (10), and seals the applicator opening (2a) in a liquid-tight manner. The head (2) is characterized in that it is designed as a truncated ellipsoid, preferably as a truncated sphere, having at least one upper bottom surface, the drug delivery opening (2a) being located within the upper bottom surface, and having a cross-section that increases from the neck (3) and decreases toward the drug delivery opening (2a).

2. The ampoule (10) according to the preceding claim, characterized in that, The screw-down discard section (1) provides an original label closure, wherein the screw-down discard section (1) is arranged completely above the head (2) and is connected to the head (2) only through a predetermined break point preferably designed as an annular shape.

3. The ampoule (10) according to any one of the preceding claims, characterized in that, The predetermined fracture position (1a) is located within the upper bottom surface of a truncated ellipsoid, preferably a truncated sphere, and after the screw-down discard part (1) is removed, the bottom surface is provided as a flat bottom surface, wherein the applicator opening (2a) is defined by a flat annulus surrounding the predetermined fracture position (1a).

4. The ampoule (10) according to any one of the preceding claims, characterized in that, The truncated ellipsoid, preferably a truncated sphere, forms a lower base in the transition region toward the neck (3).

5. The ampoule (10) according to any one of the preceding claims, characterized in that, The neck (3) has a cross-section that tapers from the shoulder (4) toward the head (2).

6. The ampoule (10) according to any one of the preceding claims, characterized in that, The shoulder (4) has a cross-section that tapers from the body (5) toward the neck (3).

7. The ampoule (10) according to any one of the preceding two claims, characterized in that, The neck (3) and the shoulder (4) together form a funnel.

8. The ampoule (10) according to any one of the preceding claims, characterized in that, The foot (6) is used to arrange the label (9), wherein the foot (6) is attached to the bottle body (5) below the bottle body.

9. The ampoule (10) according to any one of the preceding claims, characterized in that, The foot (6) has a substantially constant cross-section, and / or preferably the label (9) with product information is affixed to the foot (6).

10. The ampoule (10) according to any one of the preceding claims, characterized in that, The bottle body (5) has a cross-section that tapers from the shoulder (4) toward the foot (6), or the bottle body (5) has a substantially constant cross-section.

11. The ampoule (10) according to any one of the preceding claims, characterized in that, Product information and / or company logo are preferably embossed on the wall of the bottle body (5).

12. The ampoule (10) according to any one of the preceding claims, characterized in that, The ampoule is a single-dose delivery device and is preferably designed to hold a volume of 0.1 ml to 3.0 ml, preferably 0.3 ml to 2.0 ml, and preferably 0.8 ml to 1.5 ml.

13. The ampoule (10) according to any one of the preceding claims, characterized in that, The ampoule (10) is manufactured by blow-fill-seal technology, and / or the ampoule (10) is designed as a single piece, and / or the ampoule (10) is made of a material containing PE and / or PP.

14. An ampoule assembly (100) comprising at least two ampoules (10) according to any one of the preceding claims, characterized in that, The at least two ampoules (10) are connected to each other as one unit by a connecting piece (101).

15. A blow-fill-seal apparatus, comprising an extruder and a die-making machine with a die, wherein, The mold includes at least one cavity for forming the ampoule (10) according to any one of the preceding claims.

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