Experimental animal sterile isolation breeding cabin

Abstract

The invention provides a sterile isolated breeding cabin for experimental animals, and relates to the technical field of sterile animal breeding, and the sterile isolated breeding cabin comprises a cabin body shell, a sterile ventilation top cover structure and a middle transfer channel. A partition plate part is arranged in the cabin shell and divides the cabin shell into a feeding bin, an inner transfer channel and a bottom bin. A transfer mechanism is arranged in the inner transfer channel, comprises a sealing cover body assembly and a bearing transfer assembly and can vertically move in the channel, and it is ensured that the sterile environment of the breeding bin is not damaged when the experimental animals are transferred. The middle transfer channel is in butt joint with a transfer inlet and outlet in the side wall of the cabin shell, and safe transfer of the experimental animals under the sterile condition is achieved. Through the closed transfer design, experimental animals are prevented from making contact with the external environment, the sterile state is ensured, and meanwhile the transfer efficiency is improved. The device is suitable for sterile breeding and cross-cabin transfer of experimental animals, and meets high-standard biological experiment requirements.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of aseptic animal feeding, in particular to an experimental animal aseptic isolation feeding cabin. BACKGROUND

[0002] Experimental animals play an important role in biomedical research, and their feeding environment needs to be strictly sterile to avoid interfering with experimental results. Aseptic isolation cabins are widely used in experimental animal feeding, and the internal sterile environment is maintained by a high-efficiency filtration air exchange system. The experimental animal aseptic isolation feeding cabin is a key device for feeding aseptic or known flora animals in biomedical research, and its core goal is to exclude microbial interference and ensure the reliability of experimental results.

[0003] During the experiment, animals often need to be transferred to other experimental cabins or detection equipment. Traditional transfer methods (such as direct removal or open transfer) easily damage the sterile environment and increase the risk of contamination. In the prior art, some isolation cabins use a simple transfer window structure, but there is still a risk of short-term exposure during operation, and continuous and efficient animal transfer cannot be achieved. SUMMARY

[0004] The purpose of the present application is to provide an experimental animal aseptic isolation feeding cabin to solve the technical problems presented in the background.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical solutions: An experimental animal aseptic isolation feeding cabin, comprising a cabin shell, a sterile air exchange top cover structure, and an intermediate transfer channel. The sterile air exchange top cover structure is arranged at the top of the cabin shell and is used to adjust the sterile environment inside the cabin shell. A partition is arranged inside the cabin shell, which divides the inside of the cabin shell into a feeding bin, an internal transfer channel, and a bottom bin. The internal transfer channel is located inside the cabin shell near the side wall and is in communication with the feeding bin. A transfer exit is formed in the bottom of the outer wall of the cabin shell and is in communication with the inside of the internal transfer channel. A transfer mechanism is arranged inside the internal transfer channel and can move vertically inside the internal transfer channel. The transfer mechanism comprises a closed cover assembly and a carrying and transferring assembly. The closed cover assembly is arranged inside the internal transfer channel and moves vertically inside it. The carrying and transferring assembly is arranged on the closed cover assembly and is used to support the experimental animals that need to be transferred. When the carrying and transferring assembly is in a position corresponding to the transfer exit, the closed cover assembly closes the communication between the internal transfer channel and the feeding bin at the top. The intermediate transfer channel is arranged on the side wall of the cabin shell and corresponds to the transfer exit. The carrying and transferring assembly can move inside the intermediate transfer channel. Two long-sleeved gloves are further arranged on the side wall of the cabin shell, and one end of each long-sleeved glove extends into the feeding bin.

[0006] On the basis of the above-mentioned technical solutions, the present application further provides the following optional technical solutions: In an alternative, the sterile ventilation top cover structure comprises a top cover part, a sterilization liquid sprayer and a ventilation integrated machine. The top cover part is detachably arranged on the top of the cabin shell. The sterilization liquid sprayer and the ventilation integrated machine are arranged on the top cover part. One end of the sterilization liquid sprayer is connected to an external liquid supply system and the other end extends into the breeding cage. The sterilization liquid sprayer is used to spray sterilization liquid in the liquid supply system into the breeding cage. The ventilation integrated machine is internally loaded with a filter, a temperature regulator, a sterilizer and a humidity regulator.

[0007] In an alternative, the intermediate transfer channel comprises a channel main body, a front sealing plate and a rear sealing plate. The channel main body is fixed on the outer wall of the cabin shell and is aligned with the transfer outlet. The front sealing plate is arranged at the end of the channel main body towards the transfer outlet and is laterally slidable. The rear sealing plate is arranged at the end of the channel main body away from the transfer outlet and is laterally slidable. The rear sealing plate and the front sealing plate are connected to the outer wall of the channel main body by opening and closing air cylinders. The end of the channel main body away from the cabin shell is also provided with a connecting flange for connecting to an external cabin.

[0008] In an alternative, the closed cover assembly comprises an upper cover, a transfer support plate and at least one transfer air cylinder. The upper cover and the transfer support plate are oppositely arranged and the edges of both are capable of sliding and sealingly cooperating with the inner wall of the inner transfer channel. The upper cover and the transfer support plate are connected by at least one hanger rod part. The carrying transfer assembly is arranged on the transfer support plate and is capable of moving from one end of the transfer support plate towards the transfer outlet into the intermediate transfer channel. The transfer air cylinder is arranged on the upper end surface of the upper cover and one end of the transfer air cylinder is connected to the top of the breeding cage.

[0009] In an alternative, the upper surface of the transfer support plate is provided with two load plate slides pointing to the intermediate transfer channel. The carrying transfer assembly comprises a transfer load plate, two lower sliding supports and a forward driving unit. The lower sliding supports are arranged at the bottom of the transfer load plate in correspondence. The lower sliding supports are slidably clamped on the corresponding load plate slides. The forward driving unit is arranged at the bottom of the transfer load plate and is used to drive the lower sliding supports to move forward along the load plate slides. The channel main body is also provided with two channel slides corresponding to the two load plate slides.

[0010] In an alternative, the transfer support plate is provided with a load plate rack parallel to the load plate slide and the channel main body is provided with a channel rack corresponding to the load plate rack along the length direction. The forward driving unit comprises a forward motor and two forward rotation shafts. The two forward rotation shafts are arranged in parallel between the two lower sliding supports. The end of the forward rotation shaft is rotationally connected to the side wall of the lower sliding support. The output end of the forward motor is connected to the end of one of the forward rotation shafts. The two forward rotation shafts are also connected by a belt transmission part. Each of the forward rotation shafts is provided with a forward gear part capable of meshing with the load plate rack and the channel rack.

[0011] In an alternative, the two lower sliding supports have protruding parts on the side walls facing away from each other, the transfer support plate is provided with two abutting units respectively located on the sides of the two lower sliding supports, the abutting unit comprises an upper top part and a movable part, the upper top part is slidably penetrated through the transfer support plate, the bottom of the upper top part is bent and connected to the bottom of the transfer support plate through a downward moving spring, the movable part is slidably arranged on the upper end surface of the transfer support plate, the end of the movable part facing the lower sliding support has an abutting part, the end of the movable part away from the lower sliding support is connected to the side of the transfer support plate through a loosening spring, the top end of the upper top part is in contact with the inclined surface of the lower surface of the movable part, and the bottom of the cabin shell has a bottom base plate; when the bearing transfer assembly is located at a position corresponding to the transfer inlet, the bottom of the upper top part abuts against the bottom base plate and moves upward.

[0012] By adopting the technical scheme, the present application has the following beneficial effects: The experimental animal aseptic isolation feeding cabin provided by the present application dynamically seals the communication between the inner transfer channel and the feeding bin in the transfer process through the closed cover body assembly, ensures that the feeding bin is always in an aseptic state, and avoids external pollution; the two ends of the intermediate transfer channel can be independently opened and closed, and cooperate with the movement of the bearing transfer assembly to realize the cross-cabin transfer of the experimental animals in a completely closed environment and eliminate the exposure risk; the long-sleeved glove design allows the staff to operate under aseptic conditions, the automatic movement of the transfer mechanism reduces human intervention, and the transfer efficiency is improved; the inner transfer channel is arranged along the side wall of the cabin, saves space, and meanwhile, the transfer outlet and the intermediate transfer channel are flexibly docked, which adapts to the needs of different external cabin bodies; the whole closed transfer mechanism is suitable for high-cleanliness experimental scenes, and guarantees the aseptic state of the experimental animals and the accuracy of experimental data. BRIEF DESCRIPTION OF DRAWINGS

[0013] In order to more clearly illustrate the specific embodiments of the present application or the technical schemes in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or the prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creating any inventive labor.

[0014] Figure 1 It is a perspective structural view of the aseptic isolation feeding cabin in one embodiment of the present application.

[0015] Figure 2 It is another perspective structural view of the aseptic isolation feeding cabin in one embodiment of the present application.

[0016] Figure 3 It is a structural view of the aseptic isolation feeding cabin without the aseptic ventilation top cover structure in one embodiment of the present application.

[0017] Figure 4 The schematic diagram of the internal structure of the cabin shell in one embodiment of the present application.

[0018] Figure 5 The schematic diagram of the structure of the bearing transfer assembly on the closed cover assembly in one embodiment of the present application.

[0019] Figure 6 The schematic diagram of the structure of the forward driving unit in one embodiment of the present application.

[0020] Figure 7 The schematic diagram of the structure of the intermediate transfer passage in one embodiment of the present application.

[0021] Figure 8 The schematic diagram of the internal structure of the intermediate transfer passage in one embodiment of the present application.

[0022] Figure 9 The schematic diagram of the structure of the abutting unit in one embodiment of the present application.

[0023] The figure mark annotation: cabin shell 100, bottom base plate 110, transparent observation window 120, control panel 130, long-sleeved gloves 140, transfer inlet and outlet 150, top cover part 200, intermediate transfer passage 300, passage main body 310, front sealing plate 320, rear sealing plate 330, opening and closing air cylinder 340, connecting flange 350, passage slide 360, passage rack 370, partition plate part 400, inner transfer passage 410, transfer mechanism 500, bearing transfer assembly 510, transfer load plate 511, lower sliding support 512, convex strip part 5121, forward driving unit 513, forward moving motor 5131, forward moving rotation shaft 5132, belt transmission part 5133, forward moving gear part 5134, upper cover 520, transfer air cylinder 530, inner compartment sensor 540, boom part 550, transfer bearing plate 560, load plate slide 561, load plate rack 562, abutting unit 570, upper top part 571, movable part 572, abutting part 573, lower moving spring 574, loosening spring 575, disinfection liquid sprayer 600, air exchange all-in-one machine 700. DETAILED DESCRIPTION

[0024] The technical solutions of the present application will be described clearly and completely below in combination with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0025] The left-right-up-down positions of various components given in the drawings are only one arrangement, and the specific positions are set according to specific needs.

[0026] In one embodiment, as shown in Figures 1-5 An experimental animal sterile isolation breeding cabin includes a cabin shell 100, a sterile ventilation top cover structure and an intermediate transfer channel 300. The sterile ventilation top cover structure is arranged at the top of the cabin shell 100 and is used to adjust the sterile environment inside the cabin shell 100. A partition part 400 is arranged inside the cabin shell 100, which divides the inside of the cabin shell 100 into a breeding bin, an inner transfer channel 410 and a bottom bin. The inner transfer channel 410 is located near the side wall inside the cabin shell 100 and is connected with the breeding bin. A transfer exit 150 is arranged at the bottom of the outer wall of the cabin shell 100 and is connected with the inside of the inner transfer channel 410. A transfer mechanism 500 is arranged inside the inner transfer channel 410. The transfer mechanism 500 can move vertically inside the inner transfer channel 410 and includes a closed cover assembly and a carrying and transferring assembly 510. The closed cover assembly is arranged inside the inner transfer channel 410 and moves vertically inside the inner transfer channel 410. The carrying and transferring assembly 510 is arranged on the closed cover assembly and is used to support the experimental animals to be transferred. When the carrying and transferring assembly 510 is located at a position corresponding to the transfer exit 150, the closed cover assembly closes the connection between the inner transfer channel 410 and the breeding bin at the top. The intermediate transfer channel 300 is arranged on the side wall of the cabin shell 100 and corresponds to the transfer exit 150. The carrying and transferring assembly 510 can move inside the intermediate transfer channel 300. Two long-sleeved gloves 140 are arranged on the side wall of the cabin shell 100 and extend to the inside of the breeding bin.

[0027] In the embodiment of the present application, the experimental animals are bred in the breeding cage; when it is needed to transfer the experimental animals from the breeding cage to other external cabin, the external cabin is installed to the end of the intermediate transfer channel 300 away from the cabin shell 100; and both ends of the intermediate transfer channel 300 are in a sealed state; the hands of the staff are inserted into the inside of the long-sleeved gloves 140, which isolate the hands of the staff and do not affect the environment in the breeding cage, and the hands of the staff place the experimental animals to be transferred on the carrying and transferring assembly 510 of the transfer mechanism 500 through the long-sleeved gloves 140, at this time, the bottom of the closure cover assembly closes the communication between the breeding cage and the inner transfer channel 410, the closure cover assembly works and moves inside the inner transfer channel 410, the carrying and transferring assembly 510 and the experimental animals thereon descend with the closure cover assembly, until the carrying and transferring assembly 510 moves to the transfer exit 150, the top of the closure cover assembly closes the communication between the inner transfer channel 410 and the breeding cage, and the closed state and the sterile environment of the breeding cage are maintained; at this time, the end of the intermediate transfer channel 300 close to the transfer exit 150 is opened, the carrying and transferring assembly 510 moves to the inside of the intermediate transfer channel 300 through the transfer exit 150, when the carrying and transferring assembly 510 and the experimental animals thereon completely enter the intermediate transfer channel 300, the end of the intermediate transfer channel 300 close to the transfer exit 150 is closed, the end of the intermediate transfer channel 300 close to the external cabin is opened, and the carrying and transferring assembly 510 moves along the intermediate transfer channel 300 to the external cabin, after the carrying and transferring assembly 510 moves to the external cabin, the staff quickly transfers the experimental animals of the carrying and transferring assembly 510 to the external cabin, the carrying and transferring assembly 510 moves back along the intermediate transfer channel 300 to the closure cover assembly, and then moves up to the breeding cage through the inner transfer channel 410, to perform the transfer work of the next experimental animal; when the transfer mechanism 500 performs the transfer work of the experimental animals, the closure cover assembly is used to close the communication between the inner transfer channel 410 and the breeding cage, so that the breeding cage can always be in a closed state and be adjusted by the sterile air exchange top cover structure, and the sterile state is effectively maintained; the opening and closing of both ends of the intermediate transfer channel 300 can isolate the experimental animals being transferred from the outside, avoid the contact of the experimental animals with the external environment, and ensure that the experimental animals are transferred in a sterile environment.

[0028] In one embodiment, as Figures 1-5As shown, the sterile ventilation top cover structure comprises a top cover part 200, a disinfection liquid sprayer 600 and a ventilation all-in-one machine 700, the top cover part 200 is detachably arranged at the top of the cabin shell 100, the disinfection liquid sprayer 600 and the ventilation all-in-one machine 700 are arranged on the top cover part 200, one end of the disinfection liquid sprayer 600 is connected with an external liquid supply system and the other end extends to the inside of the feeding cage, the disinfection liquid sprayer 600 is used for spraying the disinfectant in the liquid supply system into the feeding cage; the ventilation all-in-one machine 700 is internally loaded with a filter, a temperature regulator, a sterilizer and a humidity regulator; in the embodiment of the application, the ventilation all-in-one machine 700 is used for guiding the outdoor airflow to pass through the filter, the temperature regulator to adjust the temperature, the sterilizer to kill microorganisms and the humidity regulator to humidify, so as to adjust the sterile environment in the feeding cage, at the same time, the ventilation all-in-one machine 700 also discharges the airflow in the ventilation all-in-one machine 700, so as to realize ventilation; wherein the sterilizer can be an ultraviolet lamp tube or a plasma sterilizer.

[0029] In one embodiment, as shown in Figures 1-8 As shown, the intermediate transfer channel 300 comprises a channel main body 310, a front sealing plate 320 and a rear sealing plate 330, the channel main body 310 is fixed on the outer wall of the cabin shell 100 and is aligned with the transfer outlet 150, the front sealing plate 320 is arranged at the end of the channel main body 310 towards the transfer outlet 150 and is transversely slidable; the rear sealing plate 330 is arranged at the end of the channel main body 310 away from the transfer outlet 150 and is transversely slidable, the rear sealing plate 330 and the front sealing plate 320 are connected with the outer wall of the channel main body 310 through opening and closing air cylinders 340, and the end of the channel main body 310 away from the cabin shell 100 is also provided with a connecting flange 350 for connecting with an external cabin; in the embodiment of the application, the opening and closing air cylinders 340 drive the rear sealing plate 330 or the front sealing plate 320 to move transversely at the end of the channel main body 310, so as to realize the closing and opening of the end of the channel main body 310, realize the isolation from the external environment during the transfer process and ensure the sterile transfer; the connection of the connecting flange 350 with the external cabin is detachable connection, various types of cabins such as experimental cabins, medical examination cabins or breeding and pairing cabins can be installed according to needs.

[0030] In one embodiment, as shown in Figures 1-3As shown, the closed cover assembly includes an upper cover 520, a transfer support plate 560 and at least one transfer cylinder 530, the upper cover 520 and the transfer support plate 560 are oppositely arranged and the edges of both can be in sliding sealing cooperation with the inner wall of the inner transfer channel 410, the upper cover 520 and the transfer support plate 560 are connected by at least one hanger rod 550, the carrying transfer assembly 510 is arranged on the transfer support plate 560 and can move from the transfer support plate 560 to the inner intermediate transfer channel 300; the transfer cylinder 530 is arranged on the upper end surface of the upper cover 520 and one end of the transfer cylinder 530 is connected with the top of the breeding cage; in the embodiment of the application, the transfer cylinder 530 drives the vertical movement of the upper cover 520 through the telescopic action of itself, the transfer support plate 560 moves with the upper cover 520 to drive the vertical movement of the carrying transfer assembly 510, and the carrying transfer assembly 510 can move to the communication position of the inner transfer channel 410 and the breeding cage or the transfer exit 150 to realize the transfer of experimental animals; the sliding cooperation of the edges of the transfer support plate 560 and the upper cover 520 with the inner wall of the inner transfer channel 410 realizes the sealing of the breeding cage when the experimental animals are transferred; wherein, a plurality of inner cage sensors 540 are further arranged on the upper cover 520, wherein the inner cage sensors 540 correspond to temperature sensors, humidity sensors and biological sensors and other sensors for sensing the sterile environment in the breeding cage.

[0031] In one embodiment, as shown in Figures 1-8 As shown, the upper surface of the transfer support plate 560 is provided with two plate slides 561 pointing to the intermediate transfer channel 300, the carrying transfer assembly 510 includes a transfer plate 511, a lower sliding support 512 and a forward driving unit 513, the lower sliding support 512 is two and is correspondingly arranged at the bottom of the transfer plate 511, the lower sliding support 512 can be slidably clamped on the corresponding plate slide 561, and the forward driving unit 513 is arranged at the bottom of the transfer plate 511 and is used to drive the lower sliding support 512 to move forward along the plate slide 561, and the inside of the channel body 310 is further provided with two channel slides 360 which are respectively opposite to the two plate slides 561; in the embodiment of the application, the transfer plate 511 is used to carry experimental animals, and the transfer plate 511 moves vertically with the transfer support plate 560 due to the slidable clamping of the lower sliding support 512 and the plate slide 561; when the transfer support plate 560 moves to the transfer exit 150 and is opposite to the end of the channel slide 360 in the intermediate transfer channel 300, the forward driving unit 513 works, and the forward driving unit 513 drives the transfer plate 511 and the forward driving unit 513 to move along the plate slide 561 and the channel slide 360, so as to realize the transportation of experimental animals in the intermediate transfer channel 300.

[0032] In one embodiment, as shown in Figures 1-8As shown, the transport support plate 560 is provided with a wafer rack 562 parallel to the wafer slide 561, and the channel body 310 is provided with a channel rack 370 along the length direction of the channel body 310; the forward driving unit 513 comprises a forward motor 5131 and two forward rotating shafts 5132, the two forward rotating shafts 5132 are arranged in parallel between the two lower sliding supports 512, the end of the forward rotating shaft 5132 is rotationally connected with the side wall of the lower sliding support 512, the output end of the forward motor 5131 is connected with the end of one of the forward rotating shafts 5132, and the two forward rotating shafts 5132 are further connected through a belt transmission part 5133, and each of the forward rotating shafts 5132 is provided with a forward gear part 5134 which can engage with the wafer rack 562 and the channel rack 370; in the embodiment of the application, when it is needed to transport the experimental animals to the external cabin or to transport the experimental animals in the external cabin into the inward transfer channel 410, the forward rotating shaft 5132 works and drives the forward rotating shaft 5132 to rotate, since the two forward rotating shafts 5132 are connected through the belt transmission part 5133, the two forward rotating shafts 5132 rotate synchronously, so the two forward gear parts 5134 rotate synchronously, and the forward rotating shaft 5132 moves along the wafer rack 562 and the channel rack 370 by engaging with the wafer rack 562 and the channel rack 370, since the two forward gear parts 5134 rotate synchronously, the forward movement of the whole carrying and transfer assembly 510 will not be affected by the disconnection of the end of the wafer rack 562 and the end of the channel rack 370, so the lower sliding support 512 and the transfer wafer 511 move with the forward rotating shaft 5132, thereby achieving the transportation of the experimental animals.

[0033] In one embodiment, as Figures 1-9As shown, the two lower sliding supports 512 have protrusion parts 5121 on the side walls facing away from each other, and the transfer supporting plate 560 is provided with two abutting units 570 respectively located on the side of the two lower sliding supports 512, the abutting unit 570 comprises an upper top part 571 and a movable part 572, the upper top part 571 is slidably penetrated through the transfer supporting plate 560, the bottom of the upper top part 571 is bent and connected with the bottom of the transfer supporting plate 560 through a downward moving spring 574, the movable part 572 is slidably arranged on the upper end surface of the transfer supporting plate 560, the end of the movable part 572 facing the lower sliding support 512 is provided with an abutting part 573, and the end of the movable part 572 away from the lower sliding support 512 is connected with the side of the transfer supporting plate 560 through a loosening spring 575, the top end of the upper top part 571 is in contact with the inclined surface of the lower surface of the movable part 572, and the bottom of the cabin shell 100 is provided with a bottom base plate 110; when the bearing and transferring assembly 510 is located at a position corresponding to the transfer exit 150, the bottom of the upper top part 571 abuts against the bottom base plate 110 and moves upward; in the embodiment of the present application, when the bearing and transferring assembly 510 is not located at a position corresponding to the transfer exit 150, the bottom of the upper top part 571 no longer abuts against the upper surface of the bottom base plate 110, and under the elastic force of the downward moving spring 574, the upper top part 571 moves downward, the top of the upper top part 571 no longer acts on the movable part 572, the movable part 572 moves to the lower sliding support 512 under the elastic force of the loosening spring 575, the abutting part 573 abuts against the side wall of the lower sliding support 512 and limits the movement of the movable part 572 on the carrier plate slide 561 by using the friction force between the abutting part 573 and the protrusion part 5121, so as to ensure the stability of the bearing and transferring assembly 510 when moving vertically inside the inner transfer channel 410; when the bearing and transferring assembly 510 is located at a position corresponding to the transfer exit 150, the bottom of the upper top part 571 abuts against the bottom base plate 110 and moves upward, and since the top end of the upper top part 571 is in contact with the inclined surface of the bottom of the movable part 572, the upper top part 571 moving upward laterally pushes the movable part 572, so that the abutting part 573 moves away from the lower sliding support 512, so that the abutting part 573 no longer limits the movement of the lower sliding support 512, and the lower sliding support 512 is facilitated to move on the carrier plate slide 561, so as to realize the transfer of the bearing and transferring assembly 510 from the inside of the intermediate transfer channel 300 to the outside of the cabin.

[0034] In one embodiment, as Figures 1-3As shown, the outer wall of the cabin shell 100 is also provided with a transparent observation window 120 and a control panel 130, and the disinfectant sprayer 600, the air exchange integrated machine 700 and the plurality of inner bin sensors 540 are electrically connected with the control panel 130; in the embodiment of the present application, the growth of the experimental animals in the feeding bin can be observed through the transparent observation window 120, the inner bin sensor 540 senses the temperature, humidity and animal growth in the feeding bin and generates a signal, and the control panel 130 receives the sensing signal and controls the disinfectant sprayer 600 and the air exchange integrated machine 700 to work, so as to adjust the environment in the feeding bin.

[0035] The above embodiment provides an experimental animal sterile isolation feeding cabin, and the working principle is as follows: 1. Maintenance and adjustment of sterile environment Air exchange and sterilization: the air exchange integrated machine 700 in the sterile air exchange top cover structure introduces the external air into the feeding bin after filtering, sterilizing, temperature adjusting and humidifying by the built-in filter, sterilizer such as ultraviolet lamp or plasma sterilizer, temperature adjuster and humidity adjuster, and discharges the waste gas in the bin, so as to maintain a constant sterile environment.

[0036] Disinfection assistance: the disinfectant sprayer 600 can spray disinfectant into the feeding bin, further kill residual microorganisms and ensure the sterile state.

[0037] 2. Internal transfer of experimental animals Initial state: the experimental animals are located in the feeding bin, the load transfer assembly 510 of the transfer mechanism 500 is located at the upper part of the inner transfer channel 410, and the upper cover body 520 and the transfer support plate 560 of the closed cover body assembly seal the upper and lower ends of the inner transfer channel 410 respectively, so as to prevent cross contamination between the inside and outside of the bin.

[0038] Loading animals: the worker places the animals on the transfer load plate 511 through the long-sleeved gloves 140. At this time, the closed cover body assembly seals the communication between the feeding bin and the inner transfer channel 410, so as to ensure that the feeding bin is sealed.

[0039] 3. Vertical transportation and channel switching Downward movement process: the transfer cylinder 530 drives the upper cover body 520 and the transfer support plate 560 to move downward, and drives the load transfer assembly 510 to descend to the transfer inlet 150 position. At this time, the upper cover body 520 seals the top of the inner transfer channel 410, and the sterile environment of the feeding bin is maintained.

[0040] Release of abutting unit: when the transfer support plate 560 reaches the bottom, the upper top 571 of the abutting unit 570 contacts and abuts against the bottom base plate 110, pushes the movable part 572 to unlock the lower sliding support 512, and allows the load transfer assembly 510 to move transversely.

[0041] 4. Transverse transfer to the outer cabin Channel docking and sealing: The front sealing plate 320 of the intermediate transfer channel 300 is opened, and the carrying transfer assembly 510 enters the channel body 310 along the load plate slide 561 and the channel slide 360 through the gear rack engagement of the front moving drive unit 513 with the load plate rack 562 and the channel rack 370. The front sealing plate 320 is then closed to ensure sealing at both ends of the channel.

[0042] External cabin docking: The rear sealing plate 330 is opened, and the transfer load plate 511 continues to move to an external cabin such as an experimental cabin. After the staff quickly transfer the animals, the carrying transfer assembly 510 returns to the breeding cage along the original path.

[0043] 5. Dynamic environment monitoring Sensor feedback: The inner cage sensor 540 monitors the temperature, humidity, and biological indicators of the breeding cage in real time, and the data is fed back to the control panel 130. The working parameters of the air exchange all-in-one machine 700 and the disinfection liquid sprayer 600 are automatically adjusted to ensure environmental stability.

[0044] Key design advantages Dual sealing mechanism: The alternating opening and closing of the closed cover assembly and the intermediate transfer channel 300 ensure that the breeding cage is always isolated from the outside during transfer.

[0045] Automatic transfer: The collaborative design of the gear rack drive and the abutting unit realizes the precise movement and locking of the carrying assembly, avoiding manual intervention and contamination.

[0046] Modular expansion: The intermediate transfer channel can be connected to the flange 350 through the opening and closing cylinder to adapt to various external cabins, meeting the sterile transfer needs of experimental animals between different functional cabins.

[0047] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

Claims

1. A sterile isolation and rearing chamber for laboratory animals, comprising an outer shell, a sterile ventilation top cover structure, and an intermediate transfer channel, wherein the sterile ventilation top cover structure is located on the top of the outer shell and is used to regulate the sterile environment inside the outer shell, characterized in that, The outer shell of the cabin is provided with a partition section, which divides the interior of the cabin shell into a breeding bin, an internal transfer channel and a bottom bin; The internal transfer channel is located inside the outer shell of the cabin, near the side wall, and is connected to the breeding bin. A transfer entrance / exit is provided at the bottom of the outer wall of the cabin, which is connected to the interior of the internal transfer channel. The inner transfer channel is equipped with a transfer mechanism that can move vertically within the inner transfer channel and includes a closed cover assembly and a load-bearing transfer assembly. The closed cover assembly is located inside the inner transfer channel and moves vertically within it. The transport and transfer assembly is located on the closed cover assembly and is used to support the experimental animals that need to be transferred. When the transport component is in the position corresponding to the transfer inlet and outlet, the top of the closed cover component closes the connection between the inner transfer channel and the breeding bin; The intermediate transfer channel is located on the side wall of the outer shell of the cabin and corresponds to the transfer inlet and outlet, allowing the transport components to move inside the intermediate transfer channel. Two long-sleeved gloves are also installed on the side wall of the outer shell of the hull, with one end of the gloves extending into the inside of the breeding hull.

2. The sterile isolation and rearing chamber for laboratory animals according to claim 1, characterized in that, The aseptic ventilation top cover structure includes a top cover, a disinfectant sprayer, and an integrated ventilation unit. The top cover is detachably located on the top of the outer shell of the chamber. The disinfection sprayer and the integrated ventilation unit are both located on the top cover. One end of the disinfection sprayer is connected to the external liquid supply system and the other end extends into the inside of the breeding bin. The disinfection sprayer is used to spray the disinfectant in the liquid supply system into the breeding bin. The integrated ventilation unit is equipped with a filter, thermostat, sterilizer and humidity regulator.

3. The sterile isolation and rearing chamber for laboratory animals according to claim 1, characterized in that, The intermediate transfer channel includes a channel body, a front sealing plate, and a rear sealing plate; The main body of the channel is fixed to the outer wall of the cabin shell and is aligned with the transfer entrance / exit. The front sealing plate is located at the end of the main body of the channel facing the transfer entrance / exit and can slide laterally. The rear sealing plate is located at the end of the channel body away from the transfer entrance and exit and can slide laterally. The rear sealing plate and the front sealing plate are connected to the outer wall of the channel body through opening and closing cylinders. The end of the channel body away from the outer shell of the cabin also has a connecting flange for connecting to the external cabin.

4. The sterile isolation and rearing chamber for laboratory animals according to claim 3, characterized in that, The closed cover assembly includes an upper cover, a transfer support plate, and at least one transfer cylinder; The upper cover and the transfer support plate are arranged opposite to each other and both edges can slide and seal with the inner wall of the inner transfer channel. The upper cover and the transfer support plate are connected by at least one lifting rod. The carrying and transfer assembly is located on the transfer support plate and can move from one end of the transfer support plate toward the transfer inlet / outlet into the middle transfer channel; the transfer cylinder is located on the upper end face of the upper cover and one end of the transfer cylinder is connected to the top of the breeding bin.

5. The sterile isolation and rearing chamber for laboratory animals according to claim 4, characterized in that, The upper surface of the transfer support plate is provided with two plate slides pointing to the middle transfer channel. The load-bearing transfer assembly includes a transfer plate, a lower sliding support, and a forward drive unit. The lower sliding supports are two in number and are correspondingly located at the bottom of the transfer plate. The lower sliding supports can slide and lock onto the corresponding plate slides. The forward drive unit is located at the bottom of the transfer plate and is used to drive the lower sliding supports to move forward along the plate slides. The main body of the channel is also provided with two channel slides that are respectively connected to the two plate slides.

6. The sterile isolation and rearing chamber for laboratory animals according to claim 5, characterized in that, The transfer support plate is provided with a carrier plate rack parallel to the carrier plate slide, and the inside of the channel body is provided with a channel rack that can be connected to the carrier plate rack along its length direction. The forward drive unit includes a forward motor and two forward rotating shafts. The two forward rotating shafts are arranged in parallel between two lower sliding supports. The ends of the forward rotating shafts are rotatably connected to the side walls of the lower sliding supports. The output end of the forward motor is connected to the end of one of the forward rotating shafts. The two forward-moving shafts are also connected by a belt drive, and each forward-moving shaft is equipped with a forward-moving gear that can mesh with the carrier plate rack and the channel rack.

7. The sterile isolation and rearing chamber for laboratory animals according to claim 5, characterized in that, The two lower sliding supports have protruding strips on their opposite sidewalls, and the transfer support plate is provided with two abutting units located on the sides of the two lower sliding supports respectively. The clamping unit includes an upper top and a movable part; The top part can slide through the transfer support plate, the bottom of the top part is bent and connected to the bottom of the transfer support plate through a downward spring, the movable part is slidably disposed on the upper surface of the transfer support plate, the end of the movable part facing the lower sliding support has a supporting part, and the end of the movable part away from the lower sliding support is connected to the side of the transfer support plate through a release spring. The top of the upper part contacts the inclined surface of the lower surface of the movable part, and the bottom of the outer shell of the cabin has a bottom plate. When the load-bearing transfer component is located at the position corresponding to the transfer inlet / outlet, the top and bottom of the component abut against the bottom plate and move upward.

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