Efficient disinfectant containing tourmaline, grape, grapefruit and various plant extracts

Abstract

The invention discloses an efficient disinfectant containing tourmaline, grape, grapefruit and various plant extracts, which is characterized in that the disinfectant takes polyhexamethylene guanidine hydrochloride as a main bactericidal component, and also contains natural mineral tourmaline, grapefruit seed extracts and traditional Chinese medicinal material extracts; the disinfectant can be widely applied to hand disinfection (surgical hands and skin before injection), mucous membrane disinfection (medical scene private parts and oral cavities), object surface disinfection (home furnishing, fabrics and public places) and air disinfection (closed spaces such as cars, high-speed rails and airplanes), is alcohol-free, non-flammable and non-explosive, can be carried and taken in public transportation, and meets the protection requirements of all scenes such as families, hospitals and trips.

Description

Technical Field

[0001] This invention relates to the field of disinfectant technology, and in particular to a highly effective disinfectant made from tourmaline, grape, grapefruit and various plant extracts. Background Technology

[0002] In the fields of public health and daily health protection, disinfectants are key products for blocking the spread of viruses and bacteria, and their performance directly affects the protective effect and user experience. Currently, mainstream disinfectants on the market suffer from the following core pain points, making it difficult to meet diverse protection needs: 1. Short sterilization time, requiring frequent use. Most existing disinfectants (such as alcohol-based and chlorine-based disinfectants) are "instant disinfectants," meaning they only kill microorganisms upon contact and lack sustained protection. The disinfection effect ceases immediately upon human movement or contact with the external environment, requiring repeated application to maintain protection. For example, daily hand disinfection requires reapplication after each contact with public items, and home or public disinfection requires multiple applications daily. This not only increases the hassle of use but also significantly increases the actual amount of disinfectant used, raising costs.

[0003] 2. Limited composition and narrow disinfection spectrum. Traditional disinfectants often rely on a single chemical component (such as alcohol, sodium hypochlorite, or monoguanidines) to kill bacteria, resulting in significant differences in their inactivation effects on different types of microorganisms. For example, alcohol has limited effectiveness in inactivating non-enveloped viruses (such as human papillomavirus (HPV) and hand-foot-and-mouth disease virus); chlorine-containing disinfectants are highly corrosive and irritating to metals, making them unsuitable for disinfecting skin, mucous membranes, and delicate object surfaces; while some guanidine disinfectants have good stability, their inactivation ability against novel viruses (such as monkeypox virus (MPXV) and the novel coronavirus SARS-CoV-2 Omeprone strain) lacks authoritative verification, making them unsuitable for complex virus transmission scenarios.

[0004] 3. It is difficult to balance safety and functionality. In pursuit of highly effective sterilization, some disinfectants increase the concentration of active ingredients, leading to increased irritation. For example, chlorine-based disinfectants pose a risk of burns to the skin and mucous membranes, while alcohol-based disinfectants can easily cause dry skin and allergies. Low-irritant disinfectants, on the other hand, often suffer from weakened sterilization effects or insufficient stability. Furthermore, most existing disinfectants do not consider the synergistic effect of "physical protection + chemical disinfection," failing to form a long-lasting protective barrier on object or skin surfaces, making them susceptible to re-adhesion from external contaminants.

[0005] 4. Low integration of natural ingredients, insufficient environmental friendliness. Currently, most mainstream disinfectants are mainly composed of chemically synthesized ingredients. Some products contain volatile organic compounds (VOCs) or toxic residues, which may burden the environment with long-term use. A few disinfectants containing natural plant extracts lack efficient compounding technology, making it difficult for natural ingredients and chemical bactericidal ingredients to work synergistically. This results in reduced bactericidal effect or decreased stability, failing to meet the dual requirements of "natural safety" and "efficient disinfection". Summary of the Invention

[0006] In order to overcome the shortcomings of the prior art, one of the objectives of this invention is to provide a highly effective disinfectant made from tourmaline, grape, grapefruit and various plant extracts.

[0007] One of the objectives of this invention is achieved through the following technical solution: A highly effective disinfectant containing tourmaline, grapefruit, pomelo, and various plant extracts is characterized in that the disinfectant uses polyhexamethylene guanidine hydrochloride as the main bactericidal component, and also contains natural mineral tourmaline, grapefruit seed extract, and traditional Chinese medicine extracts; the traditional Chinese medicine extracts are selected from at least two of Gentiana macrophylla extract, dandelion extract, Houttuynia cordata extract, Portulaca oleracea extract, and rose extract, and Gentiana macrophylla, dandelion, Houttuynia cordata, Portulaca oleracea, and rose extract all meet the standards of the Pharmacopoeia of the People's Republic of China; The disinfectant is prepared by the following process: (1) Raw material pretreatment: Tourmaline was pulverized to nanoscale (particle size 100~500nm); grapefruit seeds were pulverized (40~60 mesh) and then extracted by reflux with 70%~80% ethanol aqueous solution for 2~3 times (1~2h each time), and concentrated under reduced pressure until no alcohol taste was obtained to obtain grapefruit seed extract; Chinese medicinal materials were pulverized (20~40 mesh) and then extracted by ultrasonic extraction with 50%~70% ethanol aqueous solution at 40~50℃ for 1~1.5h, and then filtered and concentrated to an extract with a relative density of 1.10~1.20 at 25℃ to obtain Chinese medicinal material extract; (2) Polymer penetration compounding: The aqueous solution of polyhexamethylene guanidine hydrochloride is mixed with the tourmaline, grapefruit seed extract and Chinese herbal medicine extract from step (1), and stirred for 1-2 hours at 35-45℃ and 300-500r / min. The molecular-level fusion of each component is achieved through polymer penetration technology, thereby enhancing the efficacy and adsorption of disinfectant components. (3) Small molecule encapsulation: β-cyclodextrin or hydroxypropyl-β-cyclodextrin (mass ratio of 1:5 to 1:10 with disinfectant active ingredient) is used to encapsulate the compound system in step (2) after stirring at 50 to 60°C for 0.5 to 1 h and cooling to room temperature to form a sustained-release disinfectant active ingredient. (4) Preparation of finished product: Mix the slow-release component of step (3) with deionized water, adjust the pH to 4.5~6.5, and obtain the disinfectant solution; after spraying, the disinfectant solution can form a physical invisible protective film on the surface of objects / humans, and achieve 12 hours of continuous sterilization through slow release (the sterilization rate is still >98.96% after 10~30 rinses within 12 hours), and can penetrate the cell wall of viruses / bacteria, and inactivate their proteins by dissolving, coagulating or dehydrating. At the same time, the neutralizing agent D / E can effectively eliminate its residual effect by neutralizing the broth (the neutralization product has no effect on the host cell).

[0008] Preferably, based on the total mass of the disinfectant, the mass fraction of the polyhexamethylene guanidine hydrochloride is 0.20%~0.25%; and the mass ratio of the tourmaline, grapefruit seed extract, and traditional Chinese medicine extract is 1:2~3:3~5.

[0009] Preferably, the impurity limits of the disinfectant in step (4) are: lead < 10 mg / kg, mercury < 1 mg / kg, arsenic < 2 mg / kg; the metal corrosivity is: basically no corrosion to aluminum (corrosion rate 0.0031 mm / a), copper (0.0059 mm / a), stainless steel (0.0011 mm / a), and moderate corrosion to carbon steel (0.2126 mm / a).

[0010] Preferably, the stability of the disinfectant meets the following requirements: after 36 months of storage at room temperature and ventilation in an unopened state, the decrease rate of the effective ingredient content is <10%; after 14 days of storage at 54℃, the decrease rate of the effective ingredient is <10%; after 3 months of storage at 37℃, the decrease rate is 4.8%; after 6 months of storage at 40℃, the decrease rate is 7.8%; and after 240 days of sealed storage after use, the total bacterial count is still <10 CFU / mL.

[0011] Preferably, the disinfectant's microbial killing effect meets the following requirements: For bacteria: After 1 minute of exposure to the stock solution, the average log reduction values ​​for Staphylococcus aureus (ATCC6538), Pseudomonas aeruginosa (ATCC15442), and Escherichia coli (8099) were ≥5.00; and for Helicobacter pylori and Propionibacterium acnes, the log reduction values ​​were >5.00. For fungi: After 1 minute of exposure to the undiluted solution, the average log reduction against Candida albicans (ATCC10231) was ≥4.00. For viruses: after 3 min of inactivation of the stock solution, the average log inactivation value was >4.00 for dengue virus (ATCCVR-1584), after 10 min of inactivation for monkeypox virus (MPXV, host BSC-40 cells), after 3 min of inactivation for human coronavirus 229E, and after 1 min of inactivation for novel coronavirus (SARS-CoV-2) Omeprón strain, with an inactivation rate >99.99%.

[0012] Preferably, the disinfectant is a liquid formulation, packaged in plastic bottles / drums (meeting QB / T1685 appearance requirements), with sealing performance meeting the following requirements: no slippage / loosening of the cap when twisted by hand, and no leakage when inverted and squeezed; net content is selected from 20mL, 30mL, 50mL, 60mL, 100mL, 200mL, 500mL, 1.0L, 2.5L, 25.0L, and 60.0L; wherein 100mL of disinfectant can be sprayed 1300-1500 times at a spray rate of 0.07-0.08mL / spray, and 30mL of disinfectant can be sprayed 400-450 times.

[0013] Preferably, the safety of the disinfectant meets the following requirements: acute oral toxicity LD50 in NIH mice. 50 >19638mg / kg (actually non-toxic); the intensity of repeated intact skin stimulation response in New Zealand rabbits was non-irritating (0.5mL / area applied daily for 14 consecutive days, average score 0.24); the results of the micronucleus test of polychromatic erythrocytes in mouse bone marrow were negative (the micronucleus cell rate of each dose group was not significantly different from that of the solvent control group, P>0.05).

[0014] Preferably, the 12-hour continuous sterilization effect is verified by the following test: using a wooden tabletop as a carrier, artificially contaminated with bacteria (Staphylococcus aureus / Escherichia coli, initial bacterial count 1×10⁻⁶). 8 ~5×10 8 CFU / mL), after spraying disinfectant, wipe every 4 hours and then re-inoculate (bacterial count 1×10⁻⁶). 6 ~5×10 6 (CFU / mL), and the final inoculum size after 12 hours was 1×10⁻⁶. 8 ~5×10 8 CFU / mL, the kill log value is ≥3.00 after 5-15 minutes of action; and in the test of 6 volunteers, the bactericidal effect was maintained after washing hands 10 times within 12 hours (kill rate ≥96.36%) and 20-30 times (kill rate ≥98.96%).

[0015] The application of a highly effective disinfectant made from tourmaline, grape, grapefruit, and various plant extracts, characterized in that the application scenarios and methods include: Hand disinfection: Apply undiluted solution to surgical hands for 3 minutes; apply undiluted solution to intact skin for 1 minute before injection / puncture. Mucosal disinfection: Apply the undiluted solution to the mucous membranes of male and female private parts for 1 minute before and after medical treatment in medical and health institutions, and rinse the oral mucosa with the undiluted solution for 1 minute (do not use for umbilical cord mucosal disinfection). Surface disinfection: For household items (floors, toys) and public places (amusement parks, hospitals), spray / wipe with the undiluted solution and leave for 10 minutes; for fabrics (clothing, masks), soak in the undiluted solution for 10 minutes. Air disinfection: In unoccupied, enclosed spaces (car interiors, high-speed train cabins, airplane cabins), apply at 10 mL / m³. 3 Spray the mist at a controlled rate, allowing it to act for 10-15 minutes. Ventilate for 30 minutes before allowing personnel to enter.

[0016] Preferably, the disinfectant should not be used with other disinfectants, antagonistic drugs, soaps, or anionic surfactants; it contains plant extracts, and the appearance of precipitates or color differences is normal and does not affect the sterilization effect; it is also alcohol-free, non-flammable and non-explosive, and can be carried on public transportation.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. Through "polymer penetration technology + high-tech small molecule encapsulation technology", the disinfectant active ingredient (polyhexamethylene guanidine hydrochloride) forms a physical invisible protective film on the surface of objects / skin. At the same time, the active ingredient continues to play a role through slow release - even after 10 to 30 rinses (such as daily hand washing and object wiping) within 12 hours, it can still maintain a kill rate of ≥98.96% (Celescov® disinfectant hand washing - 30 times (1)(1).pdf); in the desktop carrier test, the kill log value of Staphylococcus aureus after 12 hours is ≥3.00, which completely solves the pain point of "instant disinfection requires frequent use"; 2. Due to its long-lasting protection, the frequency of use is reduced. 100mL / bottle can be sprayed 1300-1500 times. Calculated at a usage frequency of 4 times per day, it can last for 325-375 days, with a daily cost of only 0.08-0.09 yuan; 30mL / bottle can last for 100-112 days, with a daily cost of 0.09-0.10 yuan, which is far lower than alcohol disinfectant (1.5 yuan per day), balancing economy and practicality. 3. For common pathogenic bacteria such as Staphylococcus aureus (ATCC6538), Pseudomonas aeruginosa (ATCC15442), and Escherichia coli (8099), the kill log value after 1 minute of action is >5.00; for difficult-to-kill bacteria such as Helicobacter pylori and Propionibacterium acnes, the kill log value is also >5.00.

[0018] 4. It kills Candida albicans (ATCC10231) for 1 minute with a kill log value >4.00, meeting the protection requirements for skin and mucous membrane fungal infections.

[0019] 5. After 10 minutes of treatment with monkeypox virus (MPXV), 3 minutes with dengue virus (ATCCVR-1584), 1 minute with novel coronavirus Omeprón strain, and 3 minutes with human coronavirus 229E, the average log inactivation value was >4.00, and the inactivation rate was >99.99%, which is effective in responding to sudden virus transmission scenarios.

[0020] 6. It has virtually no corrosion to aluminum (corrosion rate 0.0031mm / a), copper (0.0059mm / a), and stainless steel (0.0011mm / a), and only moderate corrosion to carbon steel. It can be safely used for disinfection of household goods, medical devices, and objects in public places, avoiding damage to objects caused by traditional disinfectants.

[0021] 7. It is formulated with natural minerals (tourmaline), plant extracts (grapefruit seed, gentian, dandelion, etc.) and polyhexamethylene guanidine hydrochloride. Tourmaline enhances the adsorption of active ingredients, while plant extracts assist in sterilization and reduce irritation, avoiding the limitations of single chemical components. The Chinese medicinal materials such as gentian and dandelion in the raw materials meet the standards of the "Pharmacopoeia of the People's Republic of China", are natural and environmentally friendly, and have no toxic residues.

[0022] 8. When stored at room temperature for 36 months in an unopened state, the decrease rate of active ingredients is <10%; when stored at 54℃ for 14 days, 37℃ for 3 months, and 40℃ for 6 months, the decrease rates of active ingredients are 4.5%, 4.8%, and 7.8% respectively, which are far lower than the industry standard (decrease rate <10%); after opening, when sealed and stored for 240 days, the total bacterial count is still <10 CFU / mL, eliminating the need for frequent product replacement and reducing resource waste.

[0023] 9. It can be widely used for hand disinfection (surgical hands, skin before injection), mucosal disinfection (private parts in medical settings, oral cavity), object surface disinfection (home, fabrics, public places), and air disinfection (enclosed spaces such as car interiors, high-speed trains, and airplanes). It is alcohol-free, non-flammable and non-explosive, and can be carried on public transportation, meeting the protection needs of all scenarios such as home, hospital, and travel.

[0024] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, and to make the above and other objects, features and advantages of the present invention more apparent and understandable, preferred embodiments are described in detail below with reference to the accompanying drawings. Attached Figure Description

[0025] Figure 1 This is a flowchart of the raw material pretreatment process in this embodiment; Figure 2 This is a flowchart illustrating the core process preparation in this embodiment. Detailed Implementation

[0026] The present invention will now be further described in conjunction with the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0027] It should be noted that when a component is described as "fixed to" another component, it can be directly on the other component or may have a component in between. When a component is considered "connected to" another component, it can be directly connected to the other component or may have a component in between. When a component is considered "set on" another component, it can be directly set on the other component or may have a component in between. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0029] I. Specific Implementation Example: Preparation of Celecoxib High-Efficiency Disinfectant 1.1 Raw material composition (taking the preparation of 1000g of disinfectant as an example)

[0030] 1.2 Preparation process steps Step 1: Raw material pretreatment 1. Tourmaline crushing: The blocky tourmaline is crushed to 100~500nm using an air jet mill. The particle size distribution is detected by a laser particle size analyzer to ensure that more than 90% of the particles are within the range of 100~500nm (detection data: D10=120nm, D50=300nm, D90=480nm).

[0031] 2. Preparation of grapefruit seed extract: Take 100g of dried grapefruit seeds (40-60 mesh), add 500mL of 70% ethanol aqueous solution, and reflux at 80℃ twice, 1.5h each time; The extracts were combined and concentrated under reduced pressure at 50°C (vacuum degree -0.08MPa) until no alcohol odor remained, yielding grapefruit seed extract (yield: 18.5%). 3. Preparation of extracts from traditional Chinese medicinal materials: Take 40g, 40g, 40g, 20g, and 20g of dried Gentiana macrophylla, Taraxacum mongolicum, Houttuynia cordata, Portulaca oleracea, and Rosa rugosa respectively, and grind them into powder to 20-40 mesh. Each medicinal material was added to a 50% ethanol aqueous solution (material-to-liquid ratio 1:10) and ultrasonically extracted at 45℃ for 1.2 hours (power 300W). The residue was removed by filtration, and the filtrate was concentrated under reduced pressure at 50°C to an extract with a relative density of 1.15 at 25°C. The extract was then mixed to obtain the Chinese herbal extract (total yield: 20.3%).

[0032] Step 2: Polymer Penetration and Compounding Dissolve 2.2g of polyhexamethylene guanidine hydrochloride in 500g of deionized water and stir until completely dissolved (300r / min, 25℃). Add 20g of pretreated tourmaline, 50g of grapefruit seed extract, and 80g of traditional Chinese medicine extract. Heat to 40℃ and stir at 300r / min for 1.5h. Use a dynamic light scattering instrument to monitor the change in molecular particle size to ensure that the compound system has a uniform particle size (average particle size 50~80nm) and complete the polymer penetration fusion.

[0033] Step 3: Small molecule encapsulation 1. Add 0.55g of hydroxypropyl-β-cyclodextrin (mass ratio of 1:8 to the disinfectant active ingredient) to the compounding system in step 2, heat to 55℃, and stir at 400r / min for 0.8h; 2. Allow to cool naturally to 25℃, and use high performance liquid chromatography (HPLC) to detect the encapsulation rate, ensuring that the encapsulation rate is ≥90% (detection conditions: mobile phase methanol-water = 30:70, flow rate 1mL / min, detection wavelength 220nm).

[0034] Step 4: Finished Product Preparation 1. Add the remaining 347.05g of deionized water to the encapsulation system from step 3 and stir well; 2. Adjust the pH to 5.0 using 0.1 mol / L hydrochloric acid or sodium hydroxide (pH meter model PHS-3C, test after calibration); 3. Filter (0.22μm microporous membrane), fill into 100mL plastic bottles (meeting QB / T1685 appearance requirements), seal (no slippage or loosening of the cap when hand-tightened, no leakage when inverted and squeezed), and the finished product is Desailai High-Efficiency Disinfectant.

[0035] II. Experimental Procedure 2.1 Physicochemical index testing Experimental methods Content of active ingredient: The content of polyhexamethylene guanidine hydrochloride was detected at 545 nm using an ultraviolet spectrophotometer (model 722) according to the method in Appendix B of GB / T26367-2020. pH value: Measured directly using a pH meter according to section 2.2.1.4 of the "Disinfection Technical Specifications" (2002 edition); Impurity limits: Lead and mercury were determined using an atomic fluorescence spectrophotometer (BAF-2000) and arsenic was determined using an atomic absorption spectrophotometer (AA-6880) in accordance with the "Cosmetic Safety Technical Specifications" (2015 edition). Metal corrosivity: According to the "Disinfection Technical Specifications" (2002 edition) 2.2.4, the corrosion rate (mm / a) of disinfectant on aluminum, copper, stainless steel and carbon steel was determined.

[0036]

[0037] 2.2 Microbial Killing Effect Test 2.2.1 Bactericidal Test

[0038] 2.2.2 Fungal Killing Test

[0039] 2.2.3 Virus inactivation test

[0040] 2.3.12-hour continuous sterilization effect test 2.3.1 Desktop Carrier Persistent Sterilization Test

[0041] 2.3.2 Volunteer Handwashing Continuous Disinfection Experiment

[0042] 2.4 Stability Testing

[0043] 2.5 Safety Testing 2.5.1 Acute oral toxicity test

[0044] 2.5.2 Repeated complete skin irritation tests

[0045] 2.5.3 Mouse bone marrow polychromatic erythrocyte micronucleus test

[0046] 2.6 Cost Verification

[0047] The above embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A highly effective disinfectant containing tourmaline, grape, grapefruit, and various plant extracts, characterized in that, The disinfectant uses polyhexamethylene guanidine hydrochloride as the main bactericidal component, and also contains natural mineral tourmaline, grapefruit seed extract, and traditional Chinese medicine extracts; the traditional Chinese medicine extracts are selected from at least two of Gentiana macrophylla extract, dandelion extract, Houttuynia cordata extract, Portulaca oleracea extract, and rose extract, and Gentiana macrophylla, dandelion, Houttuynia cordata, Portulaca oleracea, and rose extract all meet the standards of the Pharmacopoeia of the People's Republic of China; The disinfectant is prepared by the following process: (1) Raw material pretreatment: Tourmaline was pulverized to nanoscale (particle size 100~500nm); grapefruit seeds were pulverized (40~60 mesh) and then extracted by reflux with 70%~80% ethanol aqueous solution for 2~3 times (1~2h each time), and concentrated under reduced pressure until no alcohol taste was obtained to obtain grapefruit seed extract; Chinese medicinal materials were pulverized (20~40 mesh) and then extracted by ultrasonic extraction with 50%~70% ethanol aqueous solution at 40~50℃ for 1~1.5h, and then filtered and concentrated to an extract with a relative density of 1.10~1.20 at 25℃ to obtain Chinese medicinal material extract; (2) Polymer penetration compounding: The aqueous solution of polyhexamethylene guanidine hydrochloride is mixed with the tourmaline, grapefruit seed extract and Chinese herbal medicine extract from step (1), and stirred for 1-2 hours at 35-45℃ and 300-500r / min. The molecular-level fusion of each component is achieved through polymer penetration technology, thereby enhancing the efficacy and adsorption of disinfectant components. (3) Small molecule encapsulation: β-cyclodextrin or hydroxypropyl-β-cyclodextrin (mass ratio of 1:5 to 1:10 with disinfectant active ingredient) is used to encapsulate the compound system in step (2) after stirring at 50 to 60°C for 0.5 to 1 h and cooling to room temperature to form a sustained-release disinfectant active ingredient. (4) Preparation of finished product: Mix the slow-release component of step (3) with deionized water, adjust the pH to 4.5~6.5, and obtain the disinfectant solution; after spraying, the disinfectant solution can form a physical invisible protective film on the surface of objects / humans, and achieve 12 hours of continuous sterilization through slow release (the sterilization rate is still >98.96% after 10~30 rinses within 12 hours), and can penetrate the cell wall of viruses / bacteria, and inactivate their proteins by dissolving, coagulating or dehydrating. At the same time, the neutralizing agent D / E can effectively eliminate its residual effect by neutralizing the broth (the neutralization product has no effect on the host cell).

2. The high-efficiency disinfectant according to claim 1, characterized in that, Based on the total mass of the disinfectant, the mass fraction of the polyhexamethylene guanidine hydrochloride is 0.20%~0.25%; the mass ratio of the tourmaline, grapefruit seed extract, and traditional Chinese medicine extract is 1:2~3:3~5.

3. The high-efficiency disinfectant according to claim 1, characterized in that, The impurity limits of the disinfectant in step (4) are: lead < 10 mg / kg, mercury < 1 mg / kg, arsenic < 2 mg / kg; the metal corrosivity is: basically no corrosion to aluminum (corrosion rate 0.0031 mm / a), copper (0.0059 mm / a), stainless steel (0.0011 mm / a), and moderate corrosion to carbon steel (0.2126 mm / a).

4. The high-efficiency disinfectant according to claim 1, characterized in that, The stability of the disinfectant meets the following requirements: when stored at room temperature and ventilation for 36 months in an unopened state, the decrease rate of the effective ingredient content is <10%; when stored at 54℃ for 14 days, the decrease rate of the effective ingredient is <10%; when stored at 37℃ for 3 months, the decrease rate is 4.8%; when stored at 40℃ for 6 months, the decrease rate is 7.8%; and when sealed and stored for 240 days after use, the total bacterial count is still <10 CFU / mL.

5. The high-efficiency disinfectant according to claim 1, characterized in that, The disinfectant's microbial killing effect meets the following requirements: For bacteria: After 1 minute of exposure to the stock solution, the average log reduction values ​​for Staphylococcus aureus (ATCC6538), Pseudomonas aeruginosa (ATCC15442), and Escherichia coli (8099) were ≥5.00; and for Helicobacter pylori and Propionibacterium acnes, the log reduction values ​​were >5.

00. For fungi: After 1 minute of exposure to the undiluted solution, the average log reduction against Candida albicans (ATCC10231) was ≥4.

00. For viruses: after 3 min of inactivation of the stock solution, the average log inactivation value was >4.00 for dengue virus (ATCCVR-1584), after 10 min of inactivation for monkeypox virus (MPXV, host BSC-40 cells), after 3 min of inactivation for human coronavirus 229E, and after 1 min of inactivation for novel coronavirus (SARS-CoV-2) Omeprón strain, with an inactivation rate >99.99%.

6. The high-efficiency disinfectant according to claim 1, characterized in that, The disinfectant is a liquid formulation, packaged in plastic bottles / drums (meeting QB / T1685 appearance requirements), with sealing performance meeting the following criteria: no slippage / loosening of the cap when twisted by hand, and no leakage when inverted and squeezed; net content is selected from 20mL, 30mL, 50mL, 60mL, 100mL, 200mL, 500mL, 1.0L, 2.5L, 25.0L, and 60.0L; 100mL of disinfectant can be sprayed 1300-1500 times at a rate of 0.07-0.08mL / spray, and 30mL of disinfectant can be sprayed 400-450 times.

7. The high-efficiency disinfectant according to claim 1, characterized in that, The safety profile of the disinfectant meets the following requirements: acute oral toxicity LD50 in NIH mice. 50 >19638mg / kg (actually non-toxic); the intensity of repeated intact skin stimulation response in New Zealand rabbits was non-irritating (0.5mL / area applied daily for 14 consecutive days, average score 0.24); the results of the micronucleus test of polychromatic erythrocytes in mouse bone marrow were negative (the micronucleus cell rate of each dose group was not significantly different from that of the solvent control group, P>0.05).

8. The high-efficiency disinfectant according to claim 1, characterized in that, The 12-hour continuous sterilization effect was verified by the following test: using a wooden tabletop as a carrier, artificially contaminated with bacteria (Staphylococcus aureus / Escherichia coli, initial bacterial count 1×10⁻⁶). 8 ~5×10 8 CFU / mL), after spraying disinfectant, wipe every 4 hours and then re-inoculate (bacterial count 1×10⁻⁶). 6 ~5×10 6 (CFU / mL), and the final inoculum size after 12 hours was 1×10⁻⁶. 8 ~5×10 8 CFU / mL, the kill log value is ≥3.00 after 5-15 minutes of action; and in the test of 6 volunteers, the bactericidal effect was maintained after washing hands 10 times within 12 hours (kill rate ≥96.36%) and 20-30 times (kill rate ≥98.96%).

9. The application of the high-efficiency disinfectant according to any one of claims 1 to 8, characterized in that, The application scenarios and methods include: Hand disinfection: Apply undiluted solution to surgical hands for 3 minutes; apply undiluted solution to intact skin for 1 minute before injection / puncture. Mucosal disinfection: Apply the undiluted solution to the mucous membranes of male and female private parts for 1 minute before and after medical treatment in medical and health institutions, and rinse the oral mucosa with the undiluted solution for 1 minute (do not use for umbilical cord mucosal disinfection). Surface disinfection: For household items (floors, toys) and public places (amusement parks, hospitals), spray / wipe with the undiluted solution and leave for 10 minutes; for fabrics (clothing, masks), soak in the undiluted solution for 10 minutes. Air disinfection: In unoccupied, enclosed spaces (car interiors, high-speed train cabins, airplane cabins), apply at 10 mL / m³. 3 Spray the mist at a controlled rate, allowing it to act for 10-15 minutes. Ventilate for 30 minutes before allowing personnel to enter.

10. The application according to claim 9, characterized in that, The disinfectant must not be used with other disinfectants, antagonistic drugs, soaps, or anionic surfactants; it contains plant extracts, so the appearance of sediment or color differences is normal and does not affect the sterilization effect; it is alcohol-free, non-flammable and non-explosive, and can be carried on public transportation.

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