Preparation method of medicament for dredging heart and cerebral vessels

Abstract

The invention discloses a preparation method of a medicament for dredging heart and cerebral vessels, which comprises the following components: 30-35 parts of red sage root, 10-15 parts of licorice, 30-35 parts of Chinese yam, 15-20 parts of peach kernel, 15-20 parts of prepared rhizome of rehmannia, 15-20 parts of red peony root, 30-35 parts of morinda meat, 4-5 parts of leech, 15-20 parts of pulp of dogwood fruit, 20-25 parts of codonopsis pilosula, 10-15 parts of trogopterus dung, 20-25 parts of bighead atractylodes rhizome, 10-15 parts of earthworm and 20-25 parts of astragalus. The key problem of cardiovascular and cerebrovascular stasis is solved in a targeted mode, multiple medicines cooperate to accurately dredge cardiovascular and cerebrovascular stasis, qi and blood circulation is improved, the situation that healthy qi is consumed by purely activating blood is avoided, and the formula is matched with multiple tonifying medicines for supporting the healthy energy.

Description

Technical Field

[0001] This invention relates to the field of cardiovascular and cerebrovascular technology, and particularly to a method for preparing a pharmaceutical agent for unblocking cardiovascular and cerebrovascular systems. Background Technology

[0002] Cardiovascular and cerebrovascular diseases (such as coronary atherosclerotic heart disease, cerebral infarction, and cerebral arteriosclerosis) are chronic diseases with high incidence, high disability rate, and high mortality rate worldwide. Their core pathological mechanism is "blood stasis" caused by vascular endothelial damage, lipid deposition, and thrombosis. Clinical manifestations include chest tightness and chest pain, dizziness and headache, limb numbness, and difficulty in movement. In severe cases, it can lead to myocardial infarction and stroke, threatening the patient's life. Modern medicine commonly uses anticoagulants (such as aspirin and clopidogrel), lipid-lowering drugs (such as statins), and vasodilators to control the condition. Although these can quickly relieve the symptoms of "stasis" (such as improving hemodynamics and preventing thrombosis), they only target the single pathological link of "blood stasis" and cannot improve the patient's pathogenesis of "qi deficiency, blood deficiency, and kidney deficiency". Summary of the Invention

[0003] The purpose of this invention is to at least solve one of the technical problems existing in the prior art, and to provide a method for preparing a medicine to clear the cardiovascular and cerebrovascular system, thus solving the problem of treating only one aspect of blood stasis.

[0004] This invention also provides a method for preparing a pharmaceutical preparation for clearing the cardiovascular and cerebrovascular systems, wherein the raw materials are composed of the following traditional Chinese medicines by weight: Salvia miltiorrhiza 30-35 parts, Glycyrrhiza uralensis 10-15 parts, Dioscorea opposita 30-35 parts, Prunus persica 15-20 parts, Rehmannia glutinosa 15-20 parts, Paeonia lactiflora 15-20 parts, Morinda officinalis 30-35 parts, Hirudo medicinalis 4-5 parts, Cornus officinalis 15-20 parts, Codonopsis pilosula 20-25 parts, Trogopterus xanthipes 10-15 parts, Atractylodes macrocephala 20-25 parts, Pheretima aspergillum 10-15 parts, Astragalus membranaceus 20-25 parts; Preparation method: S1. Soak the above-mentioned medicinal materials in water for 30-60 minutes. The water level should be 2-3cm above the medicinal materials to facilitate the dissolution of the active ingredients. S2. After bringing to a boil over high heat, reduce to low heat and simmer for 20-30 minutes. Filter out the first decoction. S3. Add water to the dregs and boil again for 15-20 minutes. Filter out the second batch of liquid. S4. Mix the two doses of medicine and take them warm in 2-3 divided doses. Preferably, the danshen (Salvia miltiorrhiza) needs to have its fibrous roots and impurities removed, be washed, moistened thoroughly, cut into thick slices, and then dried at a low temperature controlled at 40-60℃, and can be used raw; the licorice needs to have its impurities and fibrous roots removed, be washed, moistened thoroughly, cut into thick slices, dried at a low temperature controlled at 40-60℃, and then honey-fried; the yam needs to have its fibrous roots and outer skin removed, be cut into thick slices or small sections, and then stir-fried with wheat bran.

[0005] Preferably, the peach kernels need to have their shells removed and then be blanched to remove the skin; the prepared rehmannia root is already processed medicinal material and only needs to be cleaned; the red peony root needs to have its fibrous roots and impurities removed, be washed, moistened thoroughly, cut into thick slices, and then dried at a low temperature controlled at 40-60℃, and can be used raw; the morinda root needs to have its woody core removed, be washed, moistened thoroughly, cut into thick slices, and then be salt-roasted.

[0006] Preferably, the leeches need to be cleaned of impurities, washed, and dried at a low temperature controlled at 40-60℃ before being stir-fried with talc powder; the Cornus officinalis needs to be cleaned of pits and impurities before being processed with wine; the Codonopsis pilosula needs to be cleaned of impurities and rhizome, washed, soaked thoroughly, and then cut into thick slices for raw use; the Trogopterus xanthipes needs to be cleaned of impurities such as sand and soil before being processed with vinegar.

[0007] Preferably, the Atractylodes macrocephala needs to have impurities removed, be washed, moistened thoroughly, cut into thick slices, and then stir-fried with wheat bran; the earthworm needs to have impurities removed, be washed, dried at a low temperature (controlled at 40-60℃), and then processed with wine; the Astragalus membranaceus needs to have impurities and fibrous roots removed, be washed, moistened thoroughly, cut into thick slices, and then processed with honey.

[0008] Beneficial effects: The preparation method of the drug for clearing the cardiovascular and cerebrovascular system in this technical solution uses multiple potent blood-activating drugs as the core to specifically solve the key problem of cardiovascular and cerebrovascular obstruction. The synergistic effect of multiple drugs can accurately clear the stagnation of cardiovascular and cerebrovascular system, improve the circulation of qi and blood, and avoid simply activating blood and depleting the body's vital energy. The formula is combined with multiple tonifying drugs to strengthen the body's resistance and consolidate its foundation. Attached Figure Description

[0009] The present invention will be further described below with reference to the accompanying drawings and embodiments; Figure 1 This is a flowchart illustrating the preparation method of the drug for clearing cardiovascular and cerebrovascular diseases according to the present invention. Detailed Implementation

[0010] This section will describe in detail specific embodiments of the present invention. Preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and overall technical solution of the present invention, but they should not be construed as limiting the scope of protection of the present invention.

[0011] Reference Figure 1This invention discloses a method for preparing a drug to clear the cardiovascular and cerebrovascular systems. The raw materials are composed of the following Chinese medicinal herbs by weight: 30-35 parts of Salvia miltiorrhiza, 10-15 parts of Glycyrrhiza uralensis, 30-35 parts of Dioscorea opposita, 15-20 parts of Prunus persica, 15-20 parts of Rehmannia glutinosa, 15-20 parts of Paeonia lactiflora, 30-35 parts of Morinda officinalis, 4-5 parts of Hirudo medicinalis, 15-20 parts of Cornus officinalis, 20-25 parts of Codonopsis pilosula, 10-15 parts of Trogopterus xanthipes, 20-25 parts of Atractylodes macrocephala, 10-15 parts of Pheretima aspergillum, and 20-25 parts of Astragalus membranaceus. Preparation method: S1. Soak the above-mentioned medicinal materials in water for 30-60 minutes. The water level should be 2-3cm above the medicinal materials to facilitate the dissolution of the active ingredients. S2. After bringing to a boil over high heat, reduce to low heat and simmer for 20-30 minutes. Filter out the first decoction. S3. Add water to the dregs and boil again for 15-20 minutes. Filter out the second batch of liquid. S4. Mix the two doses of medicine and take them in 2-3 warm doses.

[0012] Salvia miltiorrhiza needs to have its fibrous roots and impurities removed, washed, thoroughly moistened, and then sliced ​​into 2-3mm thick slices. It should then be dried at a low temperature, controlled at 40-60℃, and can be used raw. Licorice root needs to have its impurities and fibrous roots removed, washed, thoroughly moistened, and then sliced ​​into 2-4mm thick slices. It should then be dried at a low temperature, controlled at 40-60℃, and then honey-processed (e.g., use 25-30kg of refined honey per 100kg of licorice root, stir-frying over low heat until deep yellow and no longer sticky). Dioscorea opposita needs its fibrous roots and outer skin removed and sliced ​​into 3-5mm thick slices. Alternatively, cut the yam into small pieces and then stir-fry it with wheat bran (for example, use 10 kg of wheat bran for every 100 kg of yam, stir-fry until the surface is yellow and has a caramelized aroma); the pharmacopoeia stipulates that raw danshen is more inclined to promote blood circulation and remove blood stasis, and cleaning and slicing is the basic treatment. Low-temperature drying can avoid the destruction of components (such as tanshinone); honey-processing can enhance the spleen-tonifying and qi-boosting effects of licorice and harmonize the properties of other herbs, which meets the compatibility requirement of "licorice harmonizing various herbs in cardiovascular and cerebrovascular prescriptions"; stir-fried yam with wheat bran can enhance the spleen-strengthening and diarrhea-stopping effects and avoid the slight gastrointestinal irritation of raw yam to some people.

[0013] Peach kernels need to have their shells removed, then be blanched to remove the skin (boil in boiling water for 5-8 minutes, then remove and peel off the seed coat); Rehmannia glutinosa is already processed medicinal material, so it only needs to be cleaned (remove surface debris and impurities; blocky Rehmannia glutinosa needs to be broken into 1-2cm pieces); Red peony root needs to have its fibrous roots and impurities removed, washed, thoroughly moistened, and then sliced ​​into 1-2mm thick slices, then dried at a low temperature controlled at 40-60℃, and can be used raw; Morinda officinalis pulp needs to have its woody core removed, washed, thoroughly moistened, and then sliced ​​into 2-3mm thick slices, then salt-roasted (e.g., per 100kg). Morinda officinalis pulp is stir-fried with 2kg of salt dissolved in water until slightly dry. Blanching (using boiling water) is the standard method for removing the skin of peach kernels, which can remove non-medicinal parts and reduce irritation. Rehmannia glutinosa is already a finished product after being steamed and processed with raw Rehmannia glutinosa and rice wine, so no additional processing is needed. It only needs to be cleaned to remove impurities. Raw Paeonia lactiflora is more inclined to clear heat and cool blood, disperse blood stasis and relieve pain, which is in line with the compatibility logic of "cooling blood and promoting blood circulation" in cardiovascular and cerebrovascular prescriptions. Salt-processing Morinda officinalis pulp can guide the medicine to the kidney, enhance the kidney-tonifying and yang-boosting effects of Morinda officinalis pulp, and "removing the woody core" is a necessary step in the cleansing of Morinda officinalis pulp.

[0014] Leeches need to be cleaned and impurities removed, then dried at a low temperature (40-60℃) before being stir-fried with talcum powder (e.g., 30-50 kg of talcum powder per 100 kg of leeches, stir-fried over medium heat until the surface is yellowish-brown and the texture is crisp). Cornus officinalis needs to have its pits and impurities removed before being processed with wine (e.g., 20 kg of rice wine per 100 kg of Cornus officinalis, stir-fried until the surface is purplish-black and glossy). Codonopsis pilosula needs to have impurities and rhizome removed, be cleaned, soaked thoroughly, and then sliced ​​into 2-4 mm thick slices; it can be used raw. Trogopterus xanthipes needs to have sand, soil, and other impurities removed before being processed with vinegar. Roasting (e.g., using 15-20 kg of rice vinegar per 100 kg of Wulingzhi, stir-frying until the surface is slightly black and has a vinegar aroma); talc powder roasting can reduce the toxicity of leeches (leeches are fierce and raw use can easily cause bleeding), and at the same time, it is easier to crush; wine roasting can enhance the effects of Cornus officinalis in tonifying the liver and kidneys and consolidating essence and qi, and "removing the pit" can remove the fruit pit that has no medicinal effect; Codonopsis pilosula used raw is more inclined to tonify the middle and replenish qi, and "removing the root head" is a routine cleaning step (the root head has no medicinal effect and some contain irritating components); vinegar roasting can enhance the effects of Wulingzhi in promoting blood circulation, relieving pain, removing blood stasis and stopping bleeding, while reducing its fishy smell and irritation.

[0015] Atractylodes macrocephala needs to be cleaned of impurities, washed, and thoroughly moistened before being sliced ​​into 2-3mm thick pieces. It is then stir-fried with wheat bran (e.g., 10kg of wheat bran per 100kg of Atractylodes macrocephala, stir-fried until the surface turns yellow). Earthworm needs to be cleaned of impurities, washed, and dried at a low temperature (controlled at 40-60℃), then processed with wine (e.g., 15kg of rice wine per 100kg of earthworm, stir-fried until the surface turns slightly yellow). Astragalus membranaceus needs to be cleaned of impurities and fibrous roots, washed, thoroughly moistened, and sliced ​​into 2-4mm thick pieces before processing. Honey-processed (e.g., use 25-30 kg of refined honey per 100 kg of Astragalus membranaceus, stir-fry over low heat until deep yellow and not sticky); bran-fried Atractylodes macrocephala can enhance the effects of strengthening the spleen and replenishing qi, drying dampness and harmonizing the middle jiao, which is consistent with the formula of "strengthening the spleen and replenishing qi to promote blood circulation"; wine-processed can enhance the effects of earthworm in clearing the meridians, relieving pain, clearing heat and calming the nerves, and can also correct the odor (earthworm itself has an earthy smell); honey-processed Astragalus membranaceus can enhance the effects of replenishing qi and raising yang, which is consistent with the core logic of "replenishing qi and promoting blood circulation" in cardiovascular and cerebrovascular formulas (when qi flows, blood flows).

[0016] Example 1: All medicinal materials must be processed and cleaned according to specifications. Weigh the processed medicinal materials according to the prescription dosage and place them in a ceramic, earthenware, or stainless steel container (iron, aluminum, and copper containers are strictly prohibited). Add purified water (or drinking water), with the water level covering the surface of the medicinal materials by 2-3 cm. Soak at room temperature (20-25℃) for 30-60 minutes, turning the medicinal materials every 15 minutes to ensure that all the medicinal materials fully absorb water. If the water level drops during the soaking process (such as when Rehmannia glutinosa or Dioscorea opposita absorbs water and expands), add a small amount of purified water to maintain the state of "covering the medicinal materials". Example 2: Pour the soaked herbs and soaking liquid into a decoction container and heat over high heat until boiling (stirring is required during this process to prevent the herbs from sticking to the pot). After boiling, immediately reduce the heat to low (keep the liquid at a gentle simmer to avoid violent boiling that could cause the active ingredients to evaporate). Continue to decoct for 20-30 minutes (the decoction time is started from when the heat is reduced to low). After decoction, filter the liquid while it is still hot using gauze (4-6 layers) or a filter screen (80 mesh) to collect the first decoction (keep the filter residue temporarily and do not discard it). When the temperature of the decoction drops below 40°C, it can be transferred to a clean container for temporary storage. Example 3: Add purified water to the remaining dregs, the amount of water should be 1-2 cm above the dregs (the dregs have already absorbed water, so there is no need to add too much water); heat over high heat until boiling, then reduce to low heat and continue to simmer for 15-20 minutes; filter as in Example 2, collect the second decoction, and discard the dregs (the effective components in the dregs have been basically dissolved and can be disposed of as medical waste). Example 4: Mix the two collected liquids thoroughly (the total volume of the mixed liquid is usually 400-600ml, which can be adjusted according to the number of times it is taken), and take it in 2-3 warm doses as prescribed (generally 1 dose per day, taken in the morning and evening or in the morning, noon and evening). The temperature for taking it should be 38-42℃ (avoiding excessive cold which will irritate the stomach and intestines, and excessive heat which will destroy the ingredients). If it cannot be finished at one time, it should be sealed and refrigerated (2-8℃) for no more than 24 hours. Before taking it again, it should be heated to warm.

[0017] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various modifications can be made without departing from the spirit of the present invention.

Claims

1. A method for preparing a pharmaceutical agent to clear blockages in the cardiovascular and cerebrovascular systems, characterized in that, Its raw materials consist of the following Chinese medicinal herbs by weight: Salvia miltiorrhiza 30-35 parts, Glycyrrhiza uralensis 10-15 parts, Dioscorea opposita 30-35 parts, Prunus persica 15-20 parts, Rehmannia glutinosa 15-20 parts, Paeonia lactiflora 15-20 parts, Morinda officinalis 30-35 parts, Hirudo medicinalis 4-5 parts, Cornus officinalis 15-20 parts, Codonopsis pilosula 20-25 parts, Trogopterus xanthipes 10-15 parts, Atractylodes macrocephala 20-25 parts, Pheretima aspergillum 10-15 parts, Astragalus membranaceus 20-25 parts; Preparation method: S1. Soak the above-mentioned medicinal materials in water for 30-60 minutes. The water level should be 2-3cm above the medicinal materials to facilitate the dissolution of the active ingredients. S2. After bringing to a boil over high heat, reduce to low heat and simmer for 20-30 minutes. Filter out the first decoction. S3. Add water to the dregs and boil again for 15-20 minutes. Filter out the second batch of liquid. S4. Mix the two doses of medicine and take them in 2-3 warm doses.

2. The method for preparing a pharmaceutical agent for clearing cardiovascular and cerebrovascular blockages according to claim 1, characterized in that, The danshen (Salvia miltiorrhiza) needs to have its fibrous roots and impurities removed, be washed, moistened thoroughly, cut into thick slices, and then dried at a low temperature controlled at 40-60℃. It can be used raw. The licorice root needs to have its impurities and fibrous roots removed, be washed, moistened thoroughly, cut into thick slices, dried at a low temperature controlled at 40-60℃, and then honey-fried. The yam needs to have its fibrous roots and outer skin removed, be cut into thick slices or small sections, and then stir-fried with wheat bran.

3. The method for preparing a pharmaceutical agent for clearing cardiovascular and cerebrovascular blockages according to claim 1, characterized in that, The peach kernels need to have their shells removed, and then be blanched to remove the skin; the prepared rehmannia root is already processed medicinal material, and only needs to be cleaned; the red peony root needs to have its fibrous roots and impurities removed, be washed, moistened thoroughly, cut into thick slices, and then dried at a low temperature controlled at 40-60℃, and can be used raw; the morinda root needs to have its woody core removed, be washed, moistened thoroughly, cut into thick slices, and then be salt-roasted.

4. The method for preparing a pharmaceutical agent for clearing cardiovascular and cerebrovascular blockages according to claim 1, characterized in that, The leeches need to be cleaned of impurities, washed, and dried at a low temperature controlled at 40-60℃ before being stir-fried with talc powder; the Cornus officinalis needs to be cleaned of pits and impurities before being processed with wine; the Codonopsis pilosula needs to be cleaned of impurities and rhizome, washed, soaked thoroughly, and then cut into thick slices, which can be used raw; the Trogopterus xanthipes needs to be cleaned of impurities such as sand and soil before being processed with vinegar.

5. The method for preparing a pharmaceutical agent for clearing cardiovascular and cerebrovascular blockages according to claim 1, characterized in that, The Atractylodes macrocephala needs to be cleaned of impurities, washed, moistened, and then cut into thick slices before being stir-fried with wheat bran; the Pheretima aspergillum needs to be cleaned of impurities, washed, and dried at a low temperature (controlled at 40-60℃) before being processed with wine; the Astragalus membranaceus needs to be cleaned of impurities and fibrous roots, washed, moistened, and then cut into thick slices before being processed with honey.

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