Method for extracting astragaloside IV

By using a lactic acid-betaine eutectic solvent to disrupt plant cell walls, astragaloside A extraction was achieved, overcoming the problems of low extraction rate and solvent residue in existing technologies. This method enables efficient and green extraction of astragaloside A, making it suitable for industrial production.

CN121108230APending Publication Date: 2025-12-12BEIFANG UNIV OF NATITIES
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Patent Information

Application Number
CN202511321406.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-16
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

Existing methods for extracting astragaloside A suffer from low extraction rates, long processing times, solvent toxicity residues, and high equipment costs. Traditional methods such as water extraction, alkaline water extraction, and ultrasonic-assisted extraction are inefficient, energy-intensive, and have solvent residues. Supercritical fluid extraction equipment is expensive and difficult to industrialize.

Method used

Astragalus powder was mixed with a lactic acid-betaine eutectic solvent, and the plant cell walls were disrupted by water bath shaking to extract astragaloside A. The solvent was then recovered by vacuum distillation to obtain the astragaloside A extract. (Example 1. Technical Application: This refers to the specific application scenario extracted from the title and technical field paragraphs.)

Benefits of technology

It improves the extraction efficiency of astragaloside A to ≥90%, reduces energy consumption, achieves efficient solvent recovery, simplifies the process, and is suitable for industrial production.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to an astragaloside extraction method. The active ingredient astragaloside IV of astragalus membranaceus is directly extracted by using a natural deep-eutectic solvent extraction method, betaine and lactic acid are mixed and dissolved according to the mass ratio of 5: (25-35) to obtain a lactic acid-betaine deep-eutectic solvent, astragalus membranaceus powder is added, extraction is performed through specific process parameters, the content of astragaloside IV in the extracted product is up to 4.2 mg / g, and the content of astragaloside IV in the extracted product is up to 4.2 mg / g. Compared with a traditional ethanol extraction method, the extraction rate is increased by 25%. The method has the advantages of simple and rapid process flow and easiness in industrial production.
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