Formula for preventing and treating knee osteoarthritis

Abstract

The invention discloses a formula for preventing and treating knee osteoarthritis, and relates to the technical field of traditional Chinese medicine, the formula comprises a monarch drug, a ministerial drug, an adjuvant drug and a conductant drug, the monarch drug comprises the following components by mass: 15g of rhizoma drynariae and 12g of achyranthes bidentata; the ministerial drug comprises the following components by mass: 12g of herba taxilli, 12g of radix dipsaci and 15g of radix paeoniae alba; the adjuvant medicine comprises the following components by mass: 9g of caulis sinomenii, 10g of ligusticum wallichii, 20g of caulis spatholobi, 9g of radix clematidis and 6g of radix stephaniae tetrandrae; and the conductant drug comprises the following component by mass: 6g of liquorice. Compared with the prior art, the invention has the advantages of multi-target comprehensive treatment, high safety, individualized treatment and modern pharmacological research support.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a formula for preventing and treating knee osteoarthritis. BACKGROUND

[0002] Knee osteoarthritis is a common chronic joint disease characterized by degeneration of articular cartilage and secondary hyperostosis, mainly manifested as joint pain, stiffness, limited activity and other symptoms, which seriously affects the quality of life of patients. With the aggravation of population aging, the incidence of knee osteoarthritis is increasing year by year, which brings heavy burden to society and family.

[0003] At present, the treatment methods for knee osteoarthritis mainly include drug therapy, physical therapy, surgical treatment, etc. In terms of drug therapy, commonly used are non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, intra-articular injection drugs, etc. Non-steroidal anti-inflammatory drugs can inhibit the activity of cyclooxygenase (COX) to reduce the synthesis of prostaglandins, thereby exerting anti-inflammatory and analgesic effects, but long-term use may cause gastrointestinal adverse reactions, cardiovascular risks, etc.; analgesics are mainly used to relieve pain symptoms, but have no therapeutic effect on the progression of the disease itself; intra-articular injection drugs such as sodium hyaluronate can increase the viscosity and lubrication function of joint fluid, protect articular cartilage, and promote cartilage healing and regeneration, but the treatment effect varies greatly among individuals, and some patients may have adverse reactions such as pain and allergy at the injection site.

[0004] In the field of traditional Chinese medicine, there are also many prescriptions and traditional Chinese medicine preparations for treating knee osteoarthritis. Traditional Chinese medicine believes that knee osteoarthritis belongs to the category of “Bi syndrome” and “Gubì”, and the core pathogenesis is “liver and kidney deficiency as the root and wind-cold-dampness and blood stasis blocking the collaterals as the branch”. Many traditional prescriptions have the main effects of tonifying liver and kidney, strengthening tendons and bones, expelling wind and dampness, and promoting blood circulation and removing blood stasis, which can relieve the symptoms of patients to a certain extent, but there are some shortcomings:

[0005] (1) Single treatment target: Many existing traditional Chinese medicine prescriptions only focus on treating a certain aspect, such as simply tonifying liver and kidney or simply promoting blood circulation to remove blood stasis, and fail to comprehensively regulate the complex pathogenesis of knee osteoarthritis "liver and kidney deficiency as the root and wind-cold-dampness and blood stasis blocking the collaterals as the branch", resulting in limited treatment effect and difficulty in fundamentally improving the patient's condition. (2) Safety issues: Some traditional prescriptions use toxic herbs such as Strychnos nux-vomica and Radix et Rhizoma Aconiti, which, although have certain therapeutic effects in some aspects, may cause damage to important organs such as liver and kidney if used for a long time or in excess, increasing the risk of treatment and limiting its clinical application. (3) Lack of individualized treatment: The condition of patients with knee osteoarthritis is complex and diverse, and different patients may have different syndromes, such as excessive cold, excessive dampness, obvious blood stasis, and internal heat due to yin deficiency. However, most existing traditional Chinese medicine prescriptions are fixed formulas, lack flexibility in dynamic adjustment according to the specific syndrome of the patient, and are difficult to meet the needs of individualized treatment, affecting the treatment effect. (4) Lack of support from modern pharmacological research: Some traditional prescriptions have accumulated certain experience in clinical application, but lack in-depth verification from modern pharmacological research, and their mechanisms are not clear, which makes it difficult to promote their application in a wider range and not conducive to the combination with modern medicine for comprehensive treatment. SUMMARY

[0006] The present application aims to provide a traditional Chinese medicine formula "Yishen Tongluo Qiangxi Prescription" for preventing and treating knee osteoarthritis. This formula is based on the core pathogenesis of "liver and kidney deficiency as the root and wind-cold-dampness and blood stasis blocking the collaterals as the branch" in traditional Chinese medicine, combined with modern pharmacological research, and reorganized and optimized on the basis of classical prescriptions, highlighting the synergistic effect of "tonifying liver and kidney, strengthening tendons and bones, and removing blood stasis to unblock collaterals", while considering safety, and can be dynamically adjusted according to different syndromes to achieve individualized treatment.

[0007] Specifically, the technical solution provided by the present application is a formula for preventing and treating knee osteoarthritis, which comprises monarch drug, ministerial drug, auxiliary drug and ministerial drug. The monarch drug comprises the following components in the following amounts: Radix Dipsaci 13-17g, Radix Anemarrhenae 10-14g; the ministerial drug comprises the following components in the following amounts: Radix Lonicerae 10-14g, Radix Dipsaci 10-14g, Radix Paeoniae Alba 13-17g; the auxiliary drug comprises the following components in the following amounts: Caulis Sargentodoxae 7-11g, Rhizoma Chuanxiong 8-12g, Caulis Sargentodoxae 18-22g, Radix Aristolochiae 7-11g, Radix Stephaniae Tetrandrae 4-8g; and the ministerial drug comprises the following components in the following amounts: Radix Glycyrrhizae 4-8g.

[0008] Preferably, the formula for preventing and treating knee osteoarthritis comprises monarch drug, minister drug, auxiliary drug and guide drug, the monarch drug comprises the following components by mass: rhizoma drynariae 14-16g, radix cyathulae 11-13g; the minister drug comprises the following components by mass: lonicerae japonicae 11-13g, radix stephaniae tetrandrae 11-13g, radix paeoniae alba 14-16g; the auxiliary drug comprises the following components by mass: caulis sinomenii 8-10g, chuanxiong 9-11g, caulis spatholobi 19-21g, radix clematidis 8-10g, radix sophorae flavescentis 5-7g; the guide drug comprises the following components by mass: radix glycyrrhizae 5-7g.

[0009] Preferably, the formula comprises monarch drug, minister drug, auxiliary drug and guide drug, the monarch drug comprises the following components by mass: rhizoma drynariae 15g, radix cyathulae 12g; the minister drug comprises the following components by mass: lonicerae japonicae 12g, radix stephaniae tetrandrae 12g, radix paeoniae alba 15g; the auxiliary drug comprises the following components by mass: caulis sinomenii 9g, chuanxiong 10g, caulis spatholobi 20g, radix clematidis 9g, radix sophorae flavescentis 6g; the guide drug comprises the following components by mass: radix glycyrrhizae 6g.

[0010] Preferably, the formula preparation steps comprise: step one, weighing rhizoma drynariae 15g, radix cyathulae 12g, lonicerae japonicae 12g, radix stephaniae tetrandrae 12g, radix paeoniae alba 15g, caulis sinomenii 9g, chuanxiong 10g, caulis spatholobi 20g, radix clematidis 9g, radix sophorae flavescentis 6g, radix glycyrrhizae 6g; step two, putting the above raw materials into a pot, adding water and decocting for 30 minutes; step three, taking 300ml juice after cooling.

[0011] Preferably, 300ml juice is taken twice a day, 1 dose per day, and 4 weeks are a course of treatment.

[0012] Compared with the prior art, the present application has the following advantages: (1) multi-target comprehensive treatment: the formula is comprehensive for the complex pathogenesis of knee osteoarthritis, that is, "liver and kidney deficiency is the root, and wind-cold-dampness and blood stasis are the branches", combines "tonifying kidney" and "dredging collaterals and removing blood stasis", treats the root and branch simultaneously, and the monarch drug, minister drug, auxiliary drug and guide drug have synergistic effect, so as to intervene the disease process from multiple aspects and improve the treatment effect; (2) high safety: the formula abandons toxic drugs such as strychnos and radix et rhizoma aconiti, and selects safe drugs such as radix sophorae flavescentis and radix paeoniae alba to replace, so as to reduce the risk of adverse reactions such as liver and kidney damage, and be more suitable for long-term use, especially for the elderly and the weak; (3) individualized treatment: different prescriptions are added or subtracted according to different syndromes, so as to meet the individualized needs of different patients. Clinicians can flexibly adjust the formula composition according to the specific symptoms and signs of patients, so as to improve the pertinence and effectiveness of treatment; (4) modern pharmacological research support: a plurality of drugs in the formula have definite modern pharmacological effects. For example, rhizoma drynariae contains flavonoids, which can promote chondrocyte proliferation; caulis sinomenii contains sinomenine, which can inhibit the release of inflammatory factors [TNF-α, IL-1β]; radix clematidis can soften osteophytes, and these pharmacological effects provide scientific basis for the effectiveness of the formula, and are beneficial to the combination with modern medicine for comprehensive treatment. DETAILED DESCRIPTION

[0013] Embodiment One

[0014] The present embodiment provides a formula for preventing and treating knee osteoarthritis, the component composition of which is shown in the following table:

[0015] Drug Dosage Efficacy Compatibility Role Rhizoma Drynariae 15g Nourishing kidney and strengthening bone, promoting blood circulation and relieving pain Monarch Drug Radix Anemarrhenae 12g Nourishing liver and kidney, guiding drugs downward Monarch Drug Loranthus 12g Expelling wind and dampness, nourishing liver and kidney Ministerial Drug Dipsacus 12g Connecting sinew and bone, unblocking blood vessels Ministerial Drug Radix Paeoniae Alba 15g Nourishing blood, soothing liver, relieving acute and chronic pain Ministerial Drug Caulis Lonicerae 9g Expelling wind and dampness, unblocking meridians Assistant Drug Rhizoma Chuanxiong 10g Promoting blood circulation and unblocking qi, relieving pain Assistant Drug Caulis Sargentodoxae 20g Nourishing blood, unblocking collaterals, relaxing sinews and activating collaterals Assistant Drug Radix Trichosanthis 9g Eliminating bone spurs, unblocking and relieving pain Assistant Drug Radix Stephaniae Tetrandrae 6g Promoting water and eliminating dampness, relieving pain Assistant Drug Radix Glycyrrhizae 6g Harmonizing all drugs, relieving acute and chronic pain Messenger Drug

[0016] Table 1 Formula ingredients

[0017] As can be seen from the ingredients provided in the above table, in the monarch drug,: Rhizoma Drynariae and Radix Anemarrhenae are matched, aiming at the root of "kidney deficiency and weak bones". Rhizoma Drynariae has the effect of promoting cartilage repair, and Radix Anemarrhenae can guide the drug to the knee and enhance the targeting effect. The two work together to improve the skeletal problems caused by liver and kidney deficiency from the root.

[0018] In the ministerial drug, Loranthus, Radix Dipsaci, and Radix Paeoniae Alba work together with the monarch drug to jointly exert the effects of tonifying liver and kidney and strengthening bones and tendons. Among them, Radix Paeoniae Alba can also relieve muscle spasms and reduce the muscle tension symptoms caused by joint pain in patients.

[0019] In the auxiliary drug, Caulis Lonicerae Semoiferae, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Clematidis, and Rhizoma Stephaniae Tetrandrae work together to remove wind and dampness and promote blood circulation. Radix Clematidis has a significant effect on hyperosteogeny, and Rhizoma Stephaniae Tetrandrae can reduce joint edema and improve joint function.

[0020] In the ministerial drug, Caulis Lonicerae Semoiferae, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Clematidis, and Rhizoma Stephaniae Tetrandrae work together to remove wind and dampness and promote blood circulation. Radix Clematidis has a significant effect on hyperosteogeny, and Rhizoma Stephaniae Tetrandrae can reduce joint edema and improve joint function.

[0021] Embodiment Two

[0022] The present embodiment provides a specific implementation of individualized treatment courses combined with the formula, which is of the following types:

[0023] (1) If the patient has excessive cold pathogen and cold pain in the joints that is aggravated by cold, the treatment course is recommended to add 10g of Ramulus Cinnamomi and 6g of Preparing Fuzi, and the Preparing Fuzi is decocted first for 30 minutes to warm the meridians and dispel cold.

[0024] (2) If the patient has excessive damp pathogen and joint swelling and heaviness, the treatment course is recommended to add 30g of Fructus Coicis and 9g of Rhizoma Atractylodis, which can invigorate the spleen and drain dampness.

[0025] (3) If the patient has obvious blood stasis and fixed stabbing pain with dark purple tongue, the treatment course is recommended to add 9g of Carthamus tinctorius L. and 6g of Earthworm, which can enhance the effects of removing blood stasis and unblocking collaterals.

[0026] (4) If the patient has internal heat due to yin deficiency, dry mouth, red tongue, and fear of heat, the treatment course is recommended to add 12g of Anemarrhena asphodeloides Bge. and 15g of Radix Rehmanniae, which can nourish yin and clear heat.

[0027] (5) If the patient has significant hyperosteogeny, the treatment course is recommended to add 15g of Radix Lamiophlomis rotata, which can soften the bone spurs.

[0028] Example Three

[0029] The present example provides a preparation process of the prescription, which adopts the decoction method. Take Radix Dipsaci 15g, Radix Hedysari 12g, Taxillus Sutchuenensis 12g, Radix Curculiginis 12g, Radix Paeoniae Alba 15g, Caulis Sargentodoxae 9g, Rhizoma Chuanxiong 10g, Caulis Spatholobi 20g, Radix Clematidis 9g, Radix Stephaniae Tetrandrae 6g, and Radix Glycyrrhizae 6g. If necessary, adjust the composition and dosage of drugs according to the corresponding method. Put the weighed traditional Chinese medicinal materials into a pot, add an appropriate amount of water, soak for 30 minutes, then boil with a large fire, and then simmer with a small fire for 30 minutes. After the decoction is completed, filter 300ml of juice.

[0030] Usage method and course of treatment: decoct 300ml of juice and take it twice a day in the morning and evening, 1 dose per day. Continuous use for 4 weeks is a course of treatment. Pain relief generally takes 2-4 weeks, and functional improvement takes 8-12 weeks. It is recommended to recheck the joint function every 3 months during the follow-up period.

[0031] Contraindications and precautions: pregnant women are prohibited from using this prescription. People with yin deficiency and fire exuberance should be cautious in using warm and hot drugs such as Fufang and Ramulus Cinnamomi. If these drugs are needed in the prescription for random addition and subtraction according to the symptoms, they should be used cautiously under the guidance of doctors. Cold food and drink should be avoided during medication to avoid affecting the absorption and efficacy of the drugs.

[0032] Combined treatment recommendations: this prescription can be combined with external fumigation and washing (such as hot compress with pepper + green onion + garlic decoction) or manual therapy (such as tendon stretching and pinching + joint mobilization), in order to improve the efficacy. At the same time, it can also be combined with non-steroidal anti-inflammatory drugs (such as celecoxib) for a short period of time, and then gradually transition to pure traditional Chinese medicine maintenance treatment after the symptoms are relieved.

[0033] Obviously, the above examples are only examples for clarity, and are not limited to the embodiments. For ordinary skilled persons in the art, other different forms of changes or variations can be made on the basis of the above description. Here, it is not necessary and impossible to exhaust all the embodiments. The obvious changes or variations derived therefrom are still within the protection scope of the present invention.

Claims

1. A formula for preventing and treating knee osteoarthritis, comprising a principal drug, an assistant drug, a adjuvant drug, and a guiding drug, characterized in that: The principal herb comprises the following components by weight: Drynaria fortunei 13-17g, Achyranthes bidentata 10-14g; The herbal medicine comprises the following ingredients by weight: 10-14g of Taxillus chinensis, 10-14g of Dipsacus asper, and 13-17g of Paeonia lactiflora. The adjuvant medicine comprises the following components by weight: 7-11g of Sinomenium acutum, 8-12g of Ligusticum chuanxiong, 18-22g of Spatholobus suberectus, 7-11g of Clematis chinensis, and 4-8g of Stephania tetrandra; The medicine comprises the following ingredients by weight: 4-8g of licorice.

2. The formula for preventing and treating knee osteoarthritis according to claim 1, comprising a principal drug, an assistant drug, a adjuvant drug, and a guiding drug, characterized in that: The principal herb comprises the following components by weight: Drynaria fortunei 14-16g, Achyranthes bidentata 11-13g; The herbal medicine comprises the following ingredients by weight: 11-13g of Taxillus chinensis, 11-13g of Dipsacus asper, and 14-16g of Paeonia lactiflora. The adjuvant medicine comprises the following components by weight: 8-10g of Sinomenium acutum, 9-11g of Ligusticum chuanxiong, 19-21g of Spatholobus suberectus, 8-10g of Clematis chinensis, and 5-7g of Stephania tetrandra; The medicine comprises the following ingredients by weight: 5-7g of licorice.

3. A formula for preventing and treating knee osteoarthritis according to claim 2, comprising a principal drug, an assistant drug, a adjuvant drug, and a guiding drug, characterized in that: The principal herb comprises the following components by weight: 15g of Drynaria fortunei and 12g of Achyranthes bidentata; The herbal medicine comprises the following ingredients by weight: 12g of Taxillus chinensis, 12g of Dipsacus asper, and 15g of Paeonia lactiflora; The adjuvant medicine comprises the following components by weight: 9g of Sinomenium acutum, 10g of Ligusticum chuanxiong, 20g of Spatholobus suberectus, 9g of Clematis chinensis, and 6g of Stephania tetrandra; The medicine comprises the following ingredients by weight: 6g of licorice.

4. The formula for preventing and treating knee osteoarthritis according to claim 1, characterized in that... The formulation preparation steps include: Step 1: Weigh out 15g of Drynaria fortunei, 12g of Achyranthes bidentata, 12g of Taxillus chinensis, 12g of Dipsacus asper, 15g of Paeonia lactiflora, 9g of Sinomenium acutum, 10g of Ligusticum chuanxiong, 20g of Spatholobus suberectus, 9g of Clematis chinensis, 6g of Stephania tetrandra, and 6g of Glycyrrhiza uralensis. Step 2: Put the above ingredients into a pot, add water and simmer for 30 minutes; Step 3: After cooling, extract 300ml of juice.

5. The formula for preventing and treating knee osteoarthritis according to claim 4, characterized in that: The 300ml juice is taken warm twice a day, morning and evening, one dose per day, for four consecutive weeks as one course of treatment.