Anti-caries toothpaste and preparation method thereof

Abstract

The invention discloses anti-caries toothpaste and a preparation method thereof, the anti-caries toothpaste is prepared from the following raw materials: keratin extract, sodium fluoride, sorbitol, a friction agent, sodium lauryl sulfate, sodium alginate, sodium pyrophosphate, a sweetening agent, nano-hydroxyapatite, tea tree essential oil, vitamin C, a preservative and pure water, and the keratin extract is contained in a specific proportion. As a component with special performance, the keratin extract can bring various benefits to teeth, can be combined with the surfaces of the teeth to form a protective film and reduce direct damage of acidic substances and the like to the teeth, and keratin also possibly has a certain promotion effect on remineralization of the teeth and is beneficial to maintenance of the healthy structure of the teeth, so that the tooth cleaning effect is improved. The toothpaste formula has the advantages that the toothpaste formula is simple, the structural strength of teeth is enhanced, the wear resistance of the teeth is improved, meanwhile, certain protection and repair effects on enamel are achieved, and a large number of experimental studies and data verification show that the toothpaste formula shows excellent performance.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of toothpaste, in particular to a caries-preventing toothpaste and a preparation method thereof. BACKGROUND

[0002] Caries is a progressive lesion of the hard tissues of teeth caused by a combination of various factors in the oral cavity, such as inorganic matter demineralization and organic matter decomposition, and the evolution process from color change to the formation of substantial lesions as the disease progresses. Caries is caused by the fact that food contains a large amount of carbohydrates and sugar, which not only provides energy for the life and activity of bacteria in plaque, but also makes sugar metabolized to produce organic acids through bacterial metabolism. The acids long stay on the surface of the teeth and the fossa, causing enamel demineralization and destruction, followed by the dissolution of proteins by certain bacteria to form cavities. The Chinese patent CN100563626C discloses a long-acting bacteriostatic toothpaste, which has the following advantages: 1. The oral cavity is improved to inhibit the growth of bacteria and microorganisms. The oral cavity of the human body is extremely suitable for the growth of bacteria and microorganisms. In an aerobic environment, the use of bactericides cannot completely prevent the reproduction and growth of bacteria and microorganisms. The present application changes the concept of toothpaste preparation by using bactericides, and adds bacteriostatic spices to the toothpaste by referring to the idea of fumigation therapy, so as to create an environment in the oral cavity to inhibit the growth of bacteria and microorganisms, thereby maintaining the cleanliness of the oral cavity and achieving the purpose of preventing caries and treating oral diseases. 2. The bacteriostatic effect is good. The toothpaste has a wide bacteriostatic range, high absorption efficiency, long action time, and can promote the blood circulation of oral mucosa tissue, enhance the body's immune function, improve the caries prevention ability of teeth, and reduce the occurrence of oral diseases. It has obvious effect on treating oral ulcer, and is especially suitable for occasions such as night when the oral cavity is closed for a long time. 3. Good taste. The quality of the spices used is high, the fruit aroma is rich, the taste is cool and refreshing, the fragrance is pure and lasting, and the oral odor can be quickly eliminated, which is suitable for a wide range of people. 4. The raw materials are widely available, the preparation is simple, and the production cost is low. The above-mentioned technology prevents caries by improving the bacteriostatic environment in the oral cavity, but it cannot enhance the real caries prevention ability of teeth. Therefore, the present application provides a caries-preventing toothpaste and a preparation method thereof to solve the above-mentioned problems. SUMMARY

[0003] The technical problem to be solved by the present application is the limited caries prevention effect of traditional caries-preventing toothpaste. The present application provides a caries-preventing toothpaste and a preparation method thereof to solve the above-mentioned problems.

[0004] To achieve the above object, the present application provides the following technical scheme: a caries-preventing toothpaste and a preparation method thereof, the caries-preventing toothpaste is composed of raw materials: keratin extract, sodium fluoride, sorbitol, abrasive, sodium lauryl sulfate, sodium alginate, sodium pyrophosphate, sweetener, nano-hydroxyapatite, tea tree oil, vitamin C, preservative, and pure water, the preparation raw material of the keratin extract is eggshell, wherein the keratin extract is prepared from the eggshell, can be combined with the tooth surface to form a protective film, reduces the damage of acidic substances to the teeth, can promote the remineralization of the teeth, maintains the healthy structure of the teeth, enhances the strength of the tooth structure, improves the wear resistance, has a protective and repairing effect on the tooth enamel; the sodium fluoride is helpful for the remineralization of the teeth and the resistance to acid erosion, is a common component for preventing caries; the sorbitol is usually used as a humectant or sweetener, is helpful for improving the taste and stability of the toothpaste; the abrasive such as calcium hydrogen phosphate, silicon dioxide, and eggshell powder is used for physically cleaning the teeth and removing dental plaque; the sodium lauryl sulfate is used as a surfactant, is helpful for the dispersion and stability of other components in the toothpaste; the sodium alginate can be used as a thickening agent or stabilizer, improves the texture of the toothpaste; the sodium pyrophosphate is used as an anticorrosive agent, is helpful for preventing the corrosion of the teeth and caries; the sweetener such as sodium saccharin, sucrose, and xylitol is used to increase the sweetness of the toothpaste and improve the taste; the nano-hydroxyapatite can be helpful for the repair and remineralization of the teeth; the tea tree oil has natural antibacterial properties, is helpful for reducing the number of bacteria in the oral cavity; the vitamin C is helpful for the gum health and the overall health of the oral cavity; the preservative maintains the safety and stability of the toothpaste product, prevents the growth of microorganisms; the pure water is used as a basic solvent for dissolving and mixing other components in the toothpaste; The preparation method of the caries-preventing toothpaste comprises the following steps: S1, the keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener, and vitamin C are added into a stirrer containing pure water according to the weight parts, and stirred for 15 min at a stirring rate of 300 rpm, so as to ensure that all the components are uniformly dispersed in the toothpaste matrix to form a stable mixture; the longer stirring time and the moderate stirring rate are helpful for the sufficient dissolution and mixing of the components, and improve the uniformity and stability of the toothpaste; S2, the abrasive and nano-hydroxyapatite are uniformly added into the stirrer within 5 min at a stirring rate of 300 rpm, and the uniform dispersion of the abrasive and nano-hydroxyapatite is crucial for the cleaning effect of the toothpaste; the rapid addition and high stirring rate are helpful for the uniform distribution of these particles in the toothpaste matrix, avoid clumping, and ensure the cleaning and polishing effect of the toothpaste; S3. Add the tea tree oil and preservative to the mixer according to the stated weight proportions. Mix for 5 minutes at a speed of 100 rpm. Tea tree oil and preservative are crucial for the antibacterial and preservative properties of toothpaste. A lower mixing speed helps protect the effectiveness of these sensitive ingredients and avoids damaging their structure due to excessive mixing. S4. Add sodium lauryl sulfate to the mixer at a uniform speed of 80 rpm over 15 minutes according to the stated weight proportions. After mixing, fill the toothpaste into pre-sterilized toothpaste tubes and seal them. Sodium lauryl sulfate, as a surfactant, helps stabilize the foam and cleaning performance of the toothpaste. The slower addition speed and lower mixing speed help control foam generation, avoid excessive foaming, and ensure the stability and user experience of the toothpaste.

[0005] Furthermore, the anti-caries toothpaste is composed of the following ingredients in parts by weight: 1-6 parts keratin extract, 3-4 parts sodium fluoride, 15-25 parts sorbitol, 20-40 parts abrasive, 0.8-1.2 parts sodium lauryl sulfate, 0.6-1.2 parts sodium alginate, 0.2-0.25 parts sodium pyrophosphate, 0.3-0.6 parts sweetener, 1-3 parts nano hydroxyapatite, 0.5-1 part tea tree oil, 0.5-1 part vitamin C, 0.2-0.8 parts preservative, and 15-35 parts purified water. This range of ingredient proportions provides flexibility, allowing adjustments based on specific product needs and characteristics. Simultaneously, this range also helps to explore the optimal combination of different ingredients while maintaining the basic functions of the toothpaste, achieving the best anti-caries effect and user experience.

[0006] Furthermore, the sweetener is any one of sodium saccharin, sucrose, or xylitol. Sodium saccharin is a high-sweetness, low-calorie artificial sweetener commonly used in diabetics and weight-loss foods; sucrose is a natural sweetener but may increase the risk of tooth decay; xylitol is a low-calorie natural sugar alcohol that helps reduce the risk of tooth decay and may promote tooth remineralization. In summary, these three sweeteners offer different options to meet the diverse needs of consumers regarding health, taste, and calorie intake.

[0007] Furthermore, the abrasive is any one of dicalcium phosphate, silica, and eggshell powder. These three substances, dicalcium phosphate, silica, and eggshell powder, act as abrasives in toothpaste, respectively cleaning teeth, removing plaque, and providing natural physical polishing, thus jointly promoting oral hygiene and dental health.

[0008] Furthermore, the method for preparing the keratin extract includes the following steps: A1, collect and clean a certain amount of eggshells, dry and crush to about 1mm in size, sieve and take part of the eggshell powder for use, ensure the purity of raw materials, remove impurities, provide a uniform solid basis for subsequent chemical reactions, improve reaction efficiency, and avoid the influence of large particle impurities on subsequent steps; A2, mix the eggshell powder with NaOH solution (concentration of 1mol / L), stir and react at 80℃ for 6h to obtain a reaction solution, treat with strong base NaOH to decompose and extract keratin in the eggshell, and NaOH helps to decompose other components in the eggshell and release keratin; A3, adjust the pH of the reaction solution to about 7 with HCl, fill the solution into a dialysis bag, dialyze in deionized water for 48h to obtain a keratin extract, neutralize the strong base, dialyze to remove small molecular impurities and retain keratin, purify the keratin extract during dialysis, remove impurities that may affect product quality, and ensure the purity of the extract; A4, add excess polyethylene glycol to adsorb and dehydrate the keratin extract, dry and solidify the dehydrated keratin extract in a vacuum drying oven at 60℃ to obtain a keratin product, remove the remaining water by polyethylene glycol adsorption, vacuum dry and solidify the keratin to form a dry keratin product, ensure the stability and storage convenience of the keratin product, avoid corruption or degradation caused by moisture, and obtain a keratin extract with high purity and good stability by cleaning and crushing eggshells, extracting keratin by alkali treatment, pH adjustment and dialysis purification, and polyethylene glycol dehydration and vacuum drying and solidification, which is suitable as an active ingredient in toothpaste and helps to enhance tooth structure strength and protect enamel.

[0009] Further, the amount of NaOH solution in step A2 is 3 times the weight of the eggshell, and appropriate excess NaOH helps to improve the extraction rate of keratin, ensures consistent extraction effect even in the case of slight differences in eggshell composition, and the excess NaOH also helps to remove more non-keratin impurities, laying a good foundation for subsequent purification steps.

[0010] Compared with the prior art, the beneficial effects of the present application are as follows: 1. The invention is a kind of anti-caries toothpaste and its preparation method, which contains a specific proportion of keratin extract. As a component with special properties, keratin extract can bring many benefits to teeth. It can bind to the surface of teeth and form a protective film, reducing the direct damage of acidic substances to teeth. Keratin may also have a certain promoting effect on tooth remineralization, helping to maintain the healthy structure of teeth, enhance the structural strength of teeth, and improve the wear resistance of teeth. At the same time, it has a certain protection and repair effect on enamel. Through a large number of experimental research and data verification, the toothpaste formula shows excellent performance in enamel hardness improvement, caries prevention, plaque reduction, etc. Its unique formula design and innovative application of keratin extract make it significantly different from other toothpaste products on the market. 2. The invention is a kind of anti-caries toothpaste and its preparation method. In addition to using natural keratin extract, tea tree oil has natural antibacterial properties, which can help reduce the number of bacteria in the oral cavity. Sodium pyrophosphate as an anti-corrosion agent can help prevent tooth erosion and caries, while maintaining the safety of toothpaste products. The addition of vitamin C helps maintain gum health and overall oral health. Sodium fluoride helps in tooth remineralization and resistance to acid erosion. Abrasives help physically clean teeth and remove plaque, providing consumers with a more comprehensive and effective oral care product. 3. The invention is a kind of anti-caries toothpaste and its preparation method. In the preparation process, by adding different ingredients in steps, it can ensure that each ingredient has enough time to mix evenly with the base mixture, avoiding the situation of ingredient clumping or uneven distribution, which can improve production efficiency and reduce waiting time during production. After multiple stirring of keratin extract, sodium fluoride and other substances, the solubility is guaranteed. By adding tea tree oil and preservatives later, the effective components of tea tree oil and preservatives can be prevented from being destroyed by reaction. By adding sodium lauryl sulfate at a lower stirring rate, the generation of foam can be controlled to avoid excessive foaming, which helps to maintain the stability and use of toothpaste. DETAILED DESCRIPTION

[0011] The technical solutions in the embodiments of the invention are described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the invention, not all. Based on the embodiments in the invention, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the invention. EMBODIMENT

[0012] A kind of anticaries toothpaste and its preparation method, the anticaries toothpaste is composed of the following weight parts of raw materials: keratin extract 4 parts, sodium fluoride 3 parts, sorbitol 25 parts, abrasive 20 parts, sodium lauryl sulfate 1.2 parts, sodium alginate 1.2 parts, sodium pyrophosphate 0.25 parts, sweetener 0.5 parts, nano hydroxyapatite 32 parts, tea tree oil 1 part, vitamin C 1 part, preservative 0.8 parts, the rest is pure water; The preparation method of the anticaries toothpaste, comprising the following steps: S1, according to the weight parts, keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener, vitamin C are added in the stirrer containing pure water, and stirring time is 15 min, and stirring rate is 300 rpm; S2, according to the weight parts, abrasive, nano hydroxyapatite are added into the stirrer at a uniform speed within 5 min, and stirring rate is 300 rpm; S3, according to the weight parts, tea tree oil, preservative are added into the stirrer, and stirring time is 5 min, and stirring rate is 100 rpm; S4, according to the weight parts, sodium lauryl sulfate is added into the stirrer at a uniform speed within 15 min, and stirring rate is 80 rpm, and after stirring is completed, the toothpaste is filled into the pre-sterilized toothpaste tube and sealed.

[0013] Further, the sweetener is xylitol.

[0014] Further, the abrasive is silicon dioxide.

[0015] Further, the preparation method of the keratin extract, comprising the following steps: A1, 1 kg of eggshell is collected and cleaned, and after drying, it is crushed to about 1 mm particle size, and 0.5 kg of eggshell powder is taken after sieving for standby use; A2, the eggshell powder is mixed with NaOH solution (concentration is 1 mol / L), and stirred at 80 DEG C for 6 h to obtain a reaction solution; A3, the pH of the reaction solution is adjusted to about 7 by using HCl, and the solution is loaded into a dialysis bag and dialyzed in deionized water for 48 h to obtain a keratin extract solution; A4, excess polyethylene glycol is added to adsorb and dehydrate the keratin extract solution, and the dehydrated keratin extract solution is dried and solidified in a vacuum drying oven at 60 DEG C to obtain a keratin product.

[0016] Further, the amount of NaOH solution in step A2 is 1.5 kg. Embodiment

[0017] Compared with example 1, the raw material ratio is different in the preparation process of the anticaries toothpaste, and the rest refers to example 1.

[0018] A caries-preventive toothpaste and a preparation method thereof, the caries-preventive toothpaste being composed of the following raw materials in parts by weight: keratin extract 2 parts, sodium fluoride 3 parts, sorbitol 25 parts, abrasive 20 parts, sodium lauryl sulfate 1.2 parts, sodium alginate 1.2 parts, sodium pyrophosphate 0.25 parts, sweetener 0.5 parts, nano-hydroxyapatite 32 parts, tea tree oil 1 part, vitamin C 1 part, preservative 0.8 parts, and the balance being pure water; The preparation method of the caries-preventive toothpaste, comprising the following steps: S1, adding keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener, and vitamin C in the proportions by weight into a stirrer containing pure water and stirring, the stirring time being 15 min and the stirring rate being 300 rpm; S2, uniformly adding abrasive and nano-hydroxyapatite into the stirrer at a constant speed within 5 min, the stirring rate being 300 rpm; S3, adding tea tree oil and preservative into the stirrer, the stirring time being 5 min and the stirring rate being 100 rpm; S4, uniformly adding sodium lauryl sulfate into the stirrer at a constant speed within 15 min, the stirring rate being 80 rpm, and after the stirring is completed, the toothpaste is filled into pre-sterilized toothpaste tubes and sealed.

[0019] Further, the sweetener is xylitol.

[0020] Further, the abrasive is silicon dioxide.

[0021] Further, the preparation method of the keratin extract comprises the following steps: A1, collecting and cleaning 1 kg of eggshells, drying, crushing to about 1 mm in particle size, and sieving to obtain 0.5 kg of eggshell powder for use; A2, mixing the eggshell powder with NaOH solution (concentration of 1 mol / L), stirring and reacting at 80℃ for 6 h to obtain a reaction solution; A3, adjusting the pH of the reaction solution to about 7 with HCl, filling the solution into a dialysis bag, and dialyzing in deionized water for 48 h to obtain a keratin extract solution; A4, adding excess polyethylene glycol to adsorb and dehydrate the keratin extract solution, and drying and solidifying the dehydrated keratin extract solution in a vacuum drying oven at 60℃ to obtain a keratin product.

[0022] Further, the amount of NaOH solution used in step A2 is 1.5 kg. Embodiment

[0023] The embodiment is compared with example 1, and the raw material ratio is different in the preparation process of the anti-caries toothpaste, and the rest refers to example 1.

[0024] An anti-caries toothpaste and a preparation method thereof, the anti-caries toothpaste is composed of the following raw materials in parts by weight: keratin extract 2 parts, sodium fluoride 1 part, sorbitol 25 parts, abrasive 20 parts, sodium lauryl sulfate 1.2 parts, sodium alginate 1.2 parts, sodium pyrophosphate 0.25 parts, sweetener 0.5 parts, nano-hydroxyapatite 32 parts, tea tree oil 1 part, vitamin C 1 part, preservative 0.8 parts, and the balance is pure water; The preparation method of the anti-caries toothpaste comprises the following steps: S1, according to the weight parts, the keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener and vitamin C are added into the stirrer containing pure water and stirred, the stirring time is 15 min, and the stirring rate is 300 rpm; S2, according to the weight parts, the abrasive and nano-hydroxyapatite are uniformly added into the stirrer within 5 min, and the stirring rate is 300 rpm; S3, according to the weight parts, the tea tree oil and preservative are added into the stirrer, the stirring time is 5 min, and the stirring rate is 100 rpm; S4, according to the weight parts, the sodium lauryl sulfate is uniformly added into the stirrer within 15 min, the stirring rate is 80 rpm, and after the stirring is completed, the toothpaste is filled into the pre-sterilized toothpaste tube and sealed.

[0025] Further, the sweetener is xylitol.

[0026] Further, the abrasive is silicon dioxide.

[0027] Further, the preparation method of the keratin extract comprises the following steps: A1, 1 kg of eggshell is collected and cleaned, dried and crushed to about 1 mm particle size, and 0.5 kg of eggshell powder is taken after sieving; A2, the eggshell powder is mixed with NaOH solution (concentration of 1 mol / L), stirred and reacted at 80℃ for 6h to obtain a reaction solution; A3, the pH of the reaction solution is adjusted to about 7 with HCl, the solution is loaded into a dialysis bag and dialyzed in deionized water for 48h to obtain a keratin extract solution; A4, an excess of polyethylene glycol is added to adsorb and dehydrate the keratin extract solution, and the dehydrated keratin extract solution is dried and solidified in a vacuum drying oven at 60℃ to obtain a keratin product.

[0028] Further, the amount of NaOH solution in step A2 is 1.5 kg. Example

[0029] The embodiment is compared with the embodiment 1, and the raw material components and the proportioning in the preparation process of the anti-caries toothpaste are different, and the rest refers to the embodiment 1.

[0030] An anti-caries toothpaste and a preparation method thereof, the anti-caries toothpaste is composed of the following raw materials in parts by weight: sodium fluoride 1 part, sorbitol 25 parts, friction agent 20 parts, sodium lauryl sulfate 1.2 parts, sodium alginate 1.2 parts, sodium pyrophosphate 0.25 parts, sweetener 0.5 parts, nano-hydroxyapatite 32 parts, tea tree oil 1 part, vitamin C 1 part, preservative 0.8 parts, and the balance is pure water. The preparation method of the anti-caries toothpaste comprises the following steps: S1, the keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener and vitamin C are added to the stirrer containing pure water according to the weight parts, and stirred for 15 min, and the stirring rate is 300 rpm; S2, the friction agent and nano-hydroxyapatite are uniformly added into the stirrer within 5 min at a stirring rate of 300 rpm; S3, the tea tree oil and preservative are added into the stirrer according to the weight parts, and stirred for 5 min, and the stirring rate is 100 rpm; S4, the sodium lauryl sulfate is uniformly added into the stirrer within 15 min at a stirring rate of 80 rpm, and after the stirring is completed, the toothpaste is filled into the pre-sterilized toothpaste tube and sealed.

[0031] Further, the sweetener is xylitol.

[0032] Further, the friction agent is silicon dioxide.

[0033] Further, the preparation method of the keratin extract comprises the following steps: A1, 1 kg of eggshells are collected and cleaned, dried and crushed to about 1 mm in size, and 0.5 kg of eggshell powder is taken for use; A2, the eggshell powder is mixed with NaOH solution (concentration of 1 mol / L), and stirred at 80℃ for 6h to obtain a reaction solution; A3, the pH of the reaction solution is adjusted to about 7 with HCl, and the solution is filled into a dialysis bag and dialyzed in deionized water for 48h to obtain a keratin extract; A4, an excess of polyethylene glycol is added to adsorb and dehydrate the keratin extract, and the dehydrated keratin extract is dried and solidified in a vacuum drying oven at 60℃ to obtain a keratin product.

[0034] Further, the amount of NaOH solution in step A2 is 1.5 kg.

[0035] The anti-caries toothpaste prepared in Examples 1-4 is used as an experimental group, and a common toothpaste is used as a control group for experiments as follows: The teeth of rats with basically identical tooth conditions, initial plaque indexes and initial hardness are randomly divided into 5 groups, and the teeth are brushed twice a day using the different toothpastes above to simulate tooth brushing. After each brushing, the teeth are soaked in a sucrose solution to simulate an acidic environment produced by oral bacteria. After 1 week of experiment, the tooth plaque index is re-evaluated, the tooth hardness is tested, and the changes in the tooth surface and internal structure are observed under a microscope to give an evaluation, and the results are as follows: plaque index tooth hardness evaluation of structural changes control group 3.0 4.5 severe demineralization example 1 1.0 6.0 surface smoothness example 2 1.0 5.5 no demineralization example 3 1.0 5.5 no demineralization example 4 2.0 5.0 mild demineralization Test Conclusion: The anti-caries effects of Examples 1, 2, 4, 3 and the control group decrease in turn, proving the anti-caries effect of the keratin extract component.

[0036] As can be seen above, the anti-caries toothpaste of the present application contains a keratin extract, can form a tooth protection film, reduce acid damage, promote tooth remineralization, enhance structural strength, improve wear resistance, protect tooth enamel, and has a formula containing natural antibacterial tea tree oil and vitamin C, which is helpful to gum and oral health. The preparation method ensures uniform dispersion of the components, improves stability and use feeling, experiments prove that it can effectively reduce the plaque index, enhance tooth hardness and reduce tooth structure changes.

[0037] Although embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An anticaries toothpaste and a method for preparing the same, characterized in that, The anti-caries toothpaste is composed of the following raw materials in parts by weight: keratin extract, sodium fluoride, sorbitol, abrasive, sodium lauryl sulfate, sodium alginate, sodium pyrophosphate, sweetener, nano-hydroxyapatite, tea tree oil, vitamin C, preservative, and pure water, wherein the keratin extract is prepared from eggshells; The anti-caries toothpaste is prepared by the following steps: S1, the keratin extract, sodium fluoride, sorbitol, sodium alginate, sodium pyrophosphate, sweetener, and vitamin C are added into a stirrer containing pure water according to the weight parts, and stirred for 15 min at a stirring rate of 300 rpm; S2, the abrasive and nano-hydroxyapatite are added into the stirrer at a uniform speed within 5 min at a stirring rate of 300 rpm; S3, the tea tree oil and preservative are added into the stirrer, and stirred for 5 min at a stirring rate of 100 rpm; S4, the sodium lauryl sulfate is added into the stirrer at a uniform speed within 15 min at a stirring rate of 80 rpm, and after the stirring is completed, the toothpaste is filled into pre-sterilized toothpaste tubes and sealed.

2. An anti-caries toothpaste according to claim 1, wherein The anti-caries toothpaste is composed of the following raw materials in parts by weight: keratin extract 1-6 parts, sodium fluoride 3-4 parts, sorbitol 15-25 parts, abrasive 20-40 parts, sodium lauryl sulfate 0.8-1.2 parts, sodium alginate 0.6-1.2 parts, sodium pyrophosphate 0.2-0.25 parts, sweetener 0.3-0.6 parts, nano-hydroxyapatite 1-3 parts, tea tree oil 0.5-1 part, vitamin C 0.5-1 part, preservative 0.2-0.8 part, and pure water 15-35 parts.

3. The anti-caries toothpaste and its preparation method according to claim 1, characterized in that, The sweetener is any one of sodium saccharin, sucrose, and xylitol.

4. The anti-caries toothpaste and its preparation method according to claim 1, characterized in that, The abrasive is any one of calcium hydrogen phosphate, silicon dioxide, and eggshell powder.

5. The anti-caries toothpaste and its preparation method according to claim 1, characterized in that: The keratin extract is prepared by the following steps: A1, a certain amount of eggshells is collected and cleaned, dried, and then crushed to a particle size of about 1 mm, and a part of the eggshell powder is taken for standby; A2, the eggshell powder is mixed with a NaOH solution (concentration of 1 mol / L), and stirred at 80℃ for 6 h to obtain a reaction solution; A3, the pH of the reaction solution is adjusted to about 7 with HCl, and the solution is loaded into a dialysis bag and dialyzed in deionized water for 48 h to obtain a keratin extract solution; A4, an excess amount of polyethylene glycol is added to adsorb and dehydrate the keratin extract solution, and the dehydrated keratin extract solution is dried and solidified in a vacuum drying oven at 60℃ to obtain a keratin product.

6. An anti-caries toothpaste according to claim 5, wherein the anti-caries toothpaste is prepared by the method according to claim 5. The amount of the NaOH solution used in step A2 is 3 times the weight of the eggshells.