Traditional Chinese medicine composition for treating psoriasis

Abstract

The invention relates to a traditional Chinese medicine composition for treating psoriasis, which is prepared from the following traditional Chinese medicines in parts by weight: 5-25 parts of cornu bubali, 5-25 parts of purslane, 5-25 parts of radix curcumae, 1-20 parts of radix isatidis, 1-20 parts of rhizoma dryopteris crassirhizomae, 1-20 parts of fructus forsythiae, 1-20 parts of rhizoma smilacis glabrae, 1-20 parts of fructus gardeniae and 1-20 parts of raw flos sophorae. The traditional Chinese medicine composition comprises, by weight, 1-20 parts of Chinese trumpet creeper, 1-20 parts of artemisia apiacea, 1-20 parts of folium mori, 1-20 parts of roasted rhizoma atractylodis macrocephalae and 1-10 parts of radix sophorae flavescentis. The traditional Chinese medicine composition is based on the traditional Chinese medicine theory, aims at the core pathogenesis of the psoriasis blood-heat syndrome, is rigorous in formula and clear in monarch, minister, assistant and guide, can remarkably improve the skin lesion symptom of progressive psoriasis, and is small in side effect and good in patient compliance.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically to a traditional Chinese medicine composition for treating psoriasis. Background Technology

[0002] Psoriasis, commonly known as "cowhide rash," is a common, chronic, relapsing, inflammatory skin disease. Typical lesions are scaly erythematous patches or plaques. The global prevalence is approximately 2%, with over 8.6 million patients in my country. The disease has a long course, is prone to relapse, and seriously affects patients' physical and mental health and quality of life. Its pathogenesis is complex, involving multiple factors such as genetics, immunity, and environment.

[0003] Modern medicine treats psoriasis primarily with glucocorticoids, vitamin D3 derivatives, immunosuppressants, and biological agents. While these Western medicines have some efficacy, long-term use can lead to significant side effects, high costs, and a high risk of relapse after discontinuation.

[0004] In Traditional Chinese Medicine (TCM) theory, psoriasis is often categorized under "white psoriasis" or "pine bark tinea." Active psoriasis is often diagnosed as "blood-heat syndrome," with the core pathogenesis being inherent deficiency of blood and qi, internal accumulation of blood heat, dryness and wind generation, and malnourishment of the skin. Treatment primarily focuses on clearing heat, cooling the blood, detoxifying, and dispelling wind. While various TCM formulas exist for treating psoriasis, providing a highly effective and low-side-effect compound TCM preparation specifically for active psoriasis with blood-heat syndrome remains a pressing technical challenge in this field. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a traditional Chinese medicine composition for treating psoriasis that is scientifically formulated, has significant efficacy, and has few side effects.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: The first aspect of the present invention provides a traditional Chinese medicine composition for treating psoriasis, the traditional Chinese medicine composition being prepared from buffalo horn, purslane, turmeric, isatis root, Dryopteris crassirhizoma, forsythia, Smilax glabra, gardenia, raw Sophora japonica flower, Campsis grandiflora flower, Artemisia annua, mulberry leaf, stir-fried Atractylodes macrocephala and Sophora flavescens.

[0007] Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-25 parts buffalo horn, 5-25 parts purslane, 5-25 parts turmeric, 1-20 parts isatis root, 1-20 parts Dryopteris crassirhizoma, 1-20 parts forsythia, 1-20 parts Smilax glabra, 1-20 parts gardenia, 1-20 parts raw Sophora japonica flower, 1-20 parts Campsis grandiflora flower, 1-20 parts Artemisia annua, 1-20 parts mulberry leaf, 1-20 parts stir-fried Atractylodes macrocephala, and 1-10 parts Sophora flavescens.

[0008] More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10-20 parts buffalo horn, 10-20 parts purslane, 10-20 parts turmeric, 5-15 parts isatis root, 5-15 parts Dryopteris crassirhizoma, 5-15 parts forsythia, 5-15 parts Smilax glabra, 5-15 parts gardenia, 5-15 parts raw Sophora japonica flower, 5-15 parts trumpet creeper flower, 5-15 parts Artemisia annua, 5-15 parts mulberry leaf, 5-15 parts stir-fried Atractylodes macrocephala, and 4-8 parts Sophora flavescens.

[0009] More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts buffalo horn, 15 parts purslane, 15 parts turmeric, 10 parts isatis root, 10 parts Dryopteris crassirhizoma, 10 parts forsythia, 10 parts Smilax glabra, 10 parts gardenia, 10 parts raw Sophora japonica flower, 10 parts Campsis grandiflora flower, 10 parts Artemisia annua, 10 parts mulberry leaf, 10 parts stir-fried Atractylodes macrocephala, and 6 parts Sophora flavescens.

[0010] Preferably, the traditional Chinese medicine composition further comprises pharmaceutically acceptable excipients.

[0011] Preferably, the traditional Chinese medicine composition is a topical or oral preparation.

[0012] Preferably, the dosage form of the traditional Chinese medicine composition is a decoction, oral liquid, granules, tablets, capsules, pills, patches, ointments, or gels. More preferably, the dosage form of the traditional Chinese medicine composition is a decoction.

[0013] The second aspect of the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps: taking the prescribed amount of buffalo horn, adding 3-5 times the weight of the total medicinal materials to water and decocting for 15-60 minutes, then adding the prescribed amounts of purslane, turmeric, isatis root, Dryopteris crassirhizoma, forsythia, Smilax glabra, gardenia, raw Sophora japonica, Campsis grandiflora, Artemisia annua, mulberry leaf, stir-fried Atractylodes macrocephala and Sophora flavescens to the decoction, soaking for 0.5-2 hours, bringing to a boil over high heat, then simmering over low heat for 15-60 minutes, and filtering to obtain the decoction; adding 1-3 times the weight of the total medicinal materials to the dregs again, bringing to a boil over high heat, then simmering over low heat for 10-45 minutes, and filtering to obtain the decoction, combining the two filtrates, concentrating the filtrate to a weight of 1-2 times the weight of the total medicinal materials, and optionally adding pharmaceutically acceptable excipients to obtain the final product.

[0014] Preferably, in the method, the prescribed amount of buffalo horn is added to water at a ratio of 4 times the total weight of the medicinal materials and decocted for 30 minutes.

[0015] Preferably, in the method, the Chinese herbs are soaked in water for 1 hour, then brought to a boil over high heat and simmered over low heat for 30 minutes.

[0016] Preferably, in the method, the dregs are added again with water twice the total weight of the medicinal materials, brought to a boil over high heat, and then simmered over low heat for 20 minutes.

[0017] Preferably, in the method, the filtrate is concentrated to a liquid with a weight of 1.5 times the total weight of the medicinal materials.

[0018] A third aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating psoriasis.

[0019] Preferably, the psoriasis is progressive psoriasis vulgaris.

[0020] Preferably, the psoriasis is psoriasis with blood-heat syndrome.

[0021] A fourth aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a drug that reduces the level of inflammatory factors IL-17 and / or TNF-α in serum.

[0022] Preferably, the present invention provides the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug that simultaneously reduces the levels of inflammatory factors IL-17 and TNF-α in serum.

[0023] The common pharmacological effects of the traditional Chinese medicine raw materials selected in this invention in this field are as follows: Water buffalo horn: It is cold in nature and bitter in taste, and enters the heart and liver meridians. Water buffalo horn clears heat and cools the blood, detoxifies, and calms the nerves. It is mainly used to treat febrile diseases with high fever, delirium, rashes, hematemesis, epistaxis, infantile convulsions, and mania.

[0024] Purslane: Cold in nature, sour in taste, and enters the large intestine and liver meridians. Purslane has the effects of clearing heat and detoxifying, cooling blood and stopping bleeding. It is mainly used to treat enteritis, bacillary dysentery, boils and carbuncles, snake and insect bites, hemorrhoids, eczema, erysipelas, hematochezia, hemorrhoidal bleeding, metrorrhagia, acute dermatitis, subacute dermatitis, herpes zoster, postpartum and functional uterine bleeding, appendicitis, and hookworm disease.

[0025] Turmeric: Cold in nature, pungent and bitter in taste, it enters the liver, heart, and lung meridians. Turmeric invigorates blood circulation and relieves pain, promotes qi circulation and resolves scabies, clears the heart and relieves depression, and promotes bile secretion and reduces jaundice. It is used to treat amenorrhea and dysmenorrhea, delirium due to febrile diseases, epilepsy and mania, jaundice and dark urine, chest and abdominal distension and pain, and stabbing pain. It has a central nervous system inhibitory effect, a protective effect against myocardial damage, anti-liver damage, and anti-fertility effects.

[0026] Isatis root: It is cold in nature and bitter in taste, and enters the heart and stomach meridians. Isatis root clears heat and detoxifies, cools the blood and soothes the throat. It is mainly used to treat exogenous fever, the initial stage of febrile diseases, sore throat, febrile rashes, mumps, erysipelas, carbuncles and boils.

[0027] Dryopteris crassirhizoma: Slightly cold in nature, bitter in taste, and enters the liver and stomach meridians. Dryopteris crassirhizoma clears heat and detoxifies, stops bleeding, and kills parasites. It is mainly used for epidemic colds, wind-heat headaches, febrile rashes, sores and carbuncles, metrorrhagia, and abdominal pain due to intestinal parasites.

[0028] Forsythia: Slightly cold in nature, bitter in taste, and enters the lung, heart, and small intestine meridians. Forsythia clears heat and detoxifies, reduces swelling and dissipates nodules. It is mainly used to treat carbuncles, scrofula, mastitis, erysipelas, wind-heat colds, early stages of febrile diseases, febrile diseases entering the nutritive level, high fever with thirst, delirium with rashes, and urinary retention due to heat.

[0029] Smilax glabra: It is neutral in nature, sweet and bland in taste, and enters the heart, spleen, and kidney meridians. Smilax glabra promotes diuresis and eliminates dampness, strengthens the spleen and stomach, calms the mind and soothes the nerves. It is used to treat urinary retention, edema, cough with phlegm, poor appetite and abdominal distension, diarrhea, dizziness, palpitations, insomnia, nocturnal emission, leukorrhea, dribbling urination, and vaginal discharge.

[0030] Gardenia: It is cold in nature and bitter in taste, and enters the heart, lung, and triple burner meridians. Gardenia has the functions of purging fire and relieving irritability, clearing heat and promoting diuresis, cooling blood and detoxifying. It can be used for febrile diseases with high fever, damp-heat jaundice, damp-heat urinary tract infection, and sores and carbuncles.

[0031] Sophora japonica flower: It is bitter and slightly cold in nature, and enters the liver and large intestine meridians. Sophora japonica flower has the effects of cooling blood and stopping bleeding, clearing liver fire, and is mainly used to treat hematochezia, hemorrhoids, red eyes and headache.

[0032] Trumpet creeper flower: It has a pungent and slightly cold nature, and enters the liver and pericardium meridians. Trumpet creeper flower promotes blood circulation, removes blood stasis, cools the blood, and dispels wind. It is mainly used for amenorrhea, itchy skin, and traumatic injuries.

[0033] Artemisia annua: It is cold in nature, bitter and pungent in taste, and enters the liver and gallbladder meridians. Artemisia annua clears heat and relieves summer heat, eliminates steaming fever, and stops malaria. Clinically, it is used for fever caused by summer heat, fever due to yin deficiency, night fever and morning coolness, bone steaming fever, malaria with chills and fever, and damp-heat jaundice.

[0034] Mulberry leaves: cold in nature, sweet and bitter in taste, and enter the lung and liver meridians. Mulberry leaves have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, clearing the liver and improving eyesight. They can treat wind-heat colds, dry cough due to lung heat, dizziness, headache, and red and blurred vision.

[0035] Atractylodes macrocephala: It is warm in nature, bitter and sweet in taste, and enters the spleen and stomach meridians. Atractylodes macrocephala has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It is used for spleen deficiency with poor appetite, abdominal distension and diarrhea, phlegm retention with dizziness and palpitations, edema, spontaneous sweating, and threatened abortion.

[0036] Sophora flavescens: It is cold in nature and bitter in taste, and enters the heart, liver, stomach, large intestine, and bladder meridians. Sophora flavescens has the functions of clearing heat and drying dampness, killing parasites, and promoting diuresis. It is used to treat dysentery, hematochezia, jaundice and urinary retention, leukorrhea, vulvar swelling and itching, eczema, damp sores, pruritus, scabies, leprosy, and trichomonal vaginitis.

[0037] This invention is guided by the traditional Chinese medicine theory of "clearing heat and cooling blood, detoxifying and removing blood stasis." Water buffalo horn is used as the principal ingredient, directly entering the blood to clear heat, cool the blood, detoxify, and calm the nerves, targeting the root cause of blood heat in psoriasis with powerful and specific effects. Purslane, Isatis root, Dryopteris crassirhizoma, Forsythia, Smilax glabra, Gardenia, and Sophora flavescens are used as assistant ingredients to help the principal ingredient clear heat and toxins from the blood. Sophora japonica and Campsis grandiflora are also used as assistant ingredients to help the principal ingredient clear heat from the blood and remove blood stasis. Turmeric, Artemisia annua, mulberry leaves, and stir-fried Atractylodes macrocephala are used as adjuvant ingredients. Turmeric invigorates blood and qi, clears the heart and relieves depression, thus resolving blood stasis; Artemisia annua and mulberry leaves are light and penetrating, drawing out pathogens and expelling heat pathogens from the surface; stir-fried Atractylodes macrocephala strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, and protects the spleen and stomach. All the herbs work synergistically to clear heat, cool the blood, detoxify, remove blood stasis, dispel wind, and relieve itching. The formula is comprehensive, addressing both the symptoms and the root cause, clearing heat while promoting circulation, cooling without suppressing pathogens, and attacking the pathogens without harming the body's vital energy. It aligns with the core pathogenesis of blood-heat syndrome in psoriasis.

[0038] Clinical usage: Take 2 doses of the herbal decoction of this invention daily, 100mL each time.

[0039] The beneficial effects of this invention are as follows: 1. The traditional Chinese medicine composition of the present invention is based on traditional Chinese medicine theory and targets the core pathogenesis of blood heat syndrome in psoriasis. The formulation is rigorous, with clear distinction between the principal, assistant, adjuvant, and guide herbs. Based on a large number of screening experiments, the oral traditional Chinese medicine preparation for treating psoriasis with significant efficacy has been obtained by optimizing the components and ratios of traditional Chinese medicine.

[0040] 2. Compared with the prior art, the traditional Chinese medicine composition of the present invention can significantly improve the skin lesion symptoms of psoriasis in the active stage, reduce the PASI score, and has few side effects and good patient compliance.

[0041] 3. The preparation method of the present invention is mature, the quality is controllable, and it is suitable for industrial production. Detailed Implementation

[0042] The present invention will be further described below with reference to embodiments, but the implementation of the present invention is not limited thereto. Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods.

[0043] Example 1 Add 15g of buffalo horn to 600mL of water and decoct for 30 minutes. After decoction, add 15g of purslane, 15g of turmeric, 10g of isatis root, 10g of Dryopteris crassirhizoma, 10g of forsythia, 10g of Smilax glabra, 10g of gardenia, 10g of raw Sophora japonica flower, 10g of Campsis grandiflora flower, 10g of Artemisia annua, 10g of mulberry leaf, 10g of stir-fried Atractylodes macrocephala, and 6g of Sophora flavescens. Soak for 1 hour, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Add 300mL of water to the dregs again, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to 200ml to obtain the herbal decoction 1 of this invention.

[0044] Example 2 Add 15g of buffalo horn to 600mL of water and decoct for 30 minutes. After decoction, add 10g of purslane, 10g of turmeric, 15g of isatis root, 15g of Dryopteris crassirhizoma, 10g of forsythia, 10g of Smilax glabra, 10g of gardenia, 10g of raw Sophora japonica flower, 10g of Campsis grandiflora flower, 10g of Artemisia annua, 10g of mulberry leaf, 10g of stir-fried Atractylodes macrocephala, and 6g of Sophora flavescens. Soak for 1 hour, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Add 300mL of water to the dregs again, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to 200ml to obtain the Chinese herbal decoction 2 of this invention.

[0045] Example 3 Add 15g of buffalo horn to 600mL of water and decoct for 30 minutes. After decoction, add 10g of purslane, 10g of turmeric, 10g of isatis root, 10g of Dryopteris crassirhizoma, 15g of forsythia, 15g of Smilax glabra, 10g of gardenia, 10g of raw Sophora japonica flower, 10g of Campsis grandiflora flower, 10g of Artemisia annua, 10g of mulberry leaf, 10g of stir-fried Atractylodes macrocephala, and 6g of Sophora flavescens. Soak for 1 hour, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Add 300mL of water to the dregs again, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to 200ml to obtain the herbal decoction of this invention 3.

[0046] Comparative Example 1 (Turmeric was replaced with Salvia miltiorrhiza) Add 15g of buffalo horn to 600mL of water and decoct for 30 minutes. After decoction, add 15g of purslane, 15g of salvia miltiorrhiza, 10g of isatis root, 10g of Dryopteris crassirhizoma, 10g of forsythia, 10g of Smilax glabra, 10g of gardenia, 10g of raw sophora japonica flower, 10g of trumpet creeper flower, 10g of artemisia annua, 10g of mulberry leaf, 10g of stir-fried Atractylodes macrocephala, and 6g of Sophora flavescens. Soak for 1 hour, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Add 300mL of water to the dregs again, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to 200ml to obtain the Chinese herbal decoction, which is the first ratio of the decoction.

[0047] Comparative Example 2 (purslane replaced with houttuynia cordata) Add 15g of buffalo horn to 600mL of water and decoct for 30 minutes. After decoction, add 15g of houttuynia cordata, 15g of turmeric, 10g of isatis root, 10g of dryopteris crassirhizoma, 10g of forsythia, 10g of smilax glabra, 10g of gardenia, 10g of raw sophora japonica flower, 10g of trumpet creeper flower, 10g of artemisia annua, 10g of mulberry leaf, 10g of stir-fried atractylodes macrocephala, and 6g of sophora flavescens. Soak for 1 hour, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Add 300mL of water to the dregs again, bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to 200ml to obtain the Chinese herbal decoction, which is the second ratio.

[0048] Experimental Example 1: The therapeutic effect of the herbal decoction of the present invention on a rat model of psoriasis with blood-heat syndrome. 1. Test Methods Select clean-grade male SD rats aged 6-8 weeks. Create a 2cm × 2cm hairless area on the back and apply 0.3g / cm... 2 Apply 5% imiquimod cream three times daily for 21 consecutive days. Four hours after the first daily administration of the cream, place the rats 30 cm below a UV lamp for 1 hour, once daily for 21 consecutive days. After modeling, dark red patches with dry scales are visible on the back of the rats; histopathology shows significant thickening of the stratum corneum and stratum spinosum, with neutrophil infiltration, indicating successful psoriasis modeling in rats. Sixty successfully modeled rats were randomly divided into six groups: the model group, the herbal decoction groups 1-3 of this invention, and the herbal decoction comparative examples 1-2, with 10 rats in each group. Ten rats that did not undergo modeling were used as a blank control group. Rats in the herbal decoction groups 1-3 and comparative examples 1-2 were orally administered the herbal decoction prepared in Examples 1-3 and Comparative Examples 1-2 of this invention at a dose of 10 mL / kg body weight. Rats in the blank control group and the model group were given an equal volume of physiological saline once daily for 14 consecutive days. Psoriasis area and severity (PASI score) were assessed in rats of each experimental group after the last administration of medication. Erythema, infiltration, and scaling were evaluated on a 5-point scale, with scores ranging from 0-4 representing different degrees of severity: none, mild, moderate, severe, and very severe. The sum of the scores for erythema, infiltration, and scaling was used as the PASI score (0-12 points). Twenty-four hours after the last administration, blood was collected from the aorta in the posterior abdomen of rats in each experimental group after anesthesia. The supernatant was collected after centrifugation, and the serum levels of inflammatory factors IL-17 and TNF-α were detected using ELISA.

[0049] 2. Test Results 2.1 Effects of the traditional Chinese medicine of this invention on the PASI score of rats The PASI scores of the skin lesions on the back of rats in each experimental group after administration of the decoction of this invention are shown in Table 1.

[0050] Table 1. Effects of the herbal decoction of this invention on PASI scores of dorsal skin lesions in rats.

[0051] This experiment simulated a rat model of psoriasis with blood-heat syndrome by applying imiquimod and irradiating with ultraviolet light. Imiquimod is a commonly used drug for inducing psoriasis animal models, while ultraviolet light simulates the heat evil caused by sunlight. The combined use of these two factors better reflects the pathogenesis of psoriasis with blood-heat syndrome. As shown in Table 1 above, compared with the blank control group, the PASI score of the rats in the model group was significantly increased, confirming the successful establishment of the psoriasis with blood-heat syndrome rat model. Compared with the model group and the comparative herbal decoction groups 1-2, the PASI score of the herbal decoction groups 1-3 of this invention was significantly reduced (with statistical difference), suggesting that the herbal decoction of this invention has excellent therapeutic effect on psoriasis with blood-heat syndrome.

[0052] 2.2 Effects of the traditional Chinese medicine of this invention on the levels of inflammatory factors in rat serum The serum levels of inflammatory factors IL-17 and TNF-α in rats of each experimental group after administration of the decoction of the present invention are shown in Table 2.

[0053] Table 2. Effects of the herbal decoction of the present invention on inflammatory factors in rat serum.

[0054] Inflammatory responses play a crucial role in the development and progression of psoriasis. TNF-α can promote the aggregation and adhesion of inflammatory cells, thereby triggering inflammatory responses and endothelial cell damage. IL-17, a cytokine specifically secreted by Th17 cells, can affect keratinocyte formation and endothelial cell proliferation, promoting angiogenesis at psoriatic lesions and playing a significant role in disease progression. As shown in Table 2, compared with the blank control group, the serum levels of IL-17 and TNF-α in the model group rats were significantly increased. Compared with the model group and the comparative groups of traditional Chinese medicine decoction 1-2, the serum levels of IL-17 and TNF-α in the traditional Chinese medicine decoction groups 1-3 of this invention were significantly decreased (with statistical differences), indicating that the traditional Chinese medicine decoction of this invention has an excellent effect on improving inflammatory responses.

[0055] Experimental Example 2: Effect of the herbal composition of the present invention on PASI scores of psoriasis patients 1. Test Methods Forty patients with progressive psoriasis vulgaris who met the diagnostic criteria for blood-heat syndrome were randomly divided into the treatment group and the control group, with 20 patients in each group. Inclusion criteria: ① Age 18-75 years, gender not limited; ② Patients clinically diagnosed with psoriasis vulgaris. Exclusion criteria: ① Allergy to any of the Chinese herbal ingredients; ② Pregnant or lactating women; ③ Patients with severe heart, liver, kidney, or mental illness.

[0056] The treatment group of this invention took the decoction prepared in Example 1 of this invention orally, twice a day, 100 mL each time. The control group took the traditional Chinese medicine compound Qingdai pills orally with warm water, 4 pills each time, 3 times a day. The treatment course was 6 weeks for both groups. The Psoriasis Area and Severity Index (PASI score) was performed on the patients before treatment and after 6 weeks of treatment. The specific evaluation method is as follows: First, the body was divided into 4 parts, and the head and neck, upper limbs, trunk and lower limbs were assigned an area ratio of 10%, 20%, 30% and 40% respectively. The skin lesion area was scored according to the proportion of the skin lesion area, with a score range of 0-6 points, corresponding to the skin lesion area proportions of 0%, 1-9%, 10-29%, 30-49%, 50-69%, 70-89% and 90-100% respectively. Then, scores are calculated based on three dimensions: erythema (E), infiltration (I), and scale (S), with each dimension scored from 0 to 4 (corresponding to asymptomatic, mild, moderate, severe, and very severe, respectively). These scores are then summed to obtain the skin lesion severity score: Erythema score + Infiltration score + Scale score. The PASI score for each site is calculated using the formula: Site proportion × Site lesion area score × Site lesion severity score. Finally, the PASI scores for all four sites are summed to obtain the patient's PASI value. A higher PASI score indicates a larger lesion area and more severe skin lesions.

[0057] 2. Test Results The PASI scores of patients in each experimental group before treatment and after 6 weeks of treatment are compared in Table 3 below.

[0058] Table 3. PASI scores (X±S) of patients in each experimental group before and after treatment.

[0059] As shown in Table 2 above, the PASI scores of the two experimental groups were comparable before treatment. After 6 weeks of treatment, the PASI scores of both experimental groups decreased, and the difference compared with before treatment was statistically significant. The PASI score of the treatment group of this invention was significantly lower than that of the control group after treatment. The above experimental results demonstrate that the traditional Chinese medicine composition of this invention has excellent clinical efficacy in treating psoriasis.

[0060] Although specific embodiments of the invention have been described, those skilled in the art will recognize that various changes and modifications can be made to the invention without departing from its scope or spirit. Therefore, the invention is intended to cover all such changes and modifications falling within the scope of the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating psoriasis, characterized in that, The traditional Chinese medicine composition is prepared from buffalo horn, purslane, turmeric, isatis root, Dryopteris crassirhizoma, forsythia, Smilax glabra, gardenia, raw Sophora japonica flower, Campsis grandiflora flower, Artemisia annua, mulberry leaf, stir-fried Atractylodes macrocephala and Sophora flavescens.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-25 parts buffalo horn, 5-25 parts purslane, 5-25 parts turmeric, 1-20 parts isatis root, 1-20 parts Dryopteris crassirhizoma, 1-20 parts forsythia, 1-20 parts Smilax glabra, 1-20 parts gardenia, 1-20 parts raw Sophora japonica flower, 1-20 parts Campsis grandiflora flower, 1-20 parts Artemisia annua, 1-20 parts mulberry leaf, 1-20 parts stir-fried Atractylodes macrocephala, and 1-10 parts Sophora flavescens.

3. The traditional Chinese medicine composition according to claim 2, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10-20 parts buffalo horn, 10-20 parts purslane, 10-20 parts turmeric, 5-15 parts isatis root, 5-15 parts Dryopteris crassirhizoma, 5-15 parts forsythia, 5-15 parts Smilax glabra, 5-15 parts gardenia, 5-15 parts raw Sophora japonica flower, 5-15 parts trumpet creeper flower, 5-15 parts Artemisia annua, 5-15 parts mulberry leaf, 5-15 parts stir-fried Atractylodes macrocephala, and 4-8 parts Sophora flavescens.

4. The traditional Chinese medicine composition according to claim 3, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts buffalo horn, 15 parts purslane, 15 parts turmeric, 10 parts isatis root, 10 parts Dryopteris crassirhizoma, 10 parts forsythia, 10 parts Smilax glabra, 10 parts gardenia, 10 parts raw Sophora japonica flower, 10 parts Campsis grandiflora flower, 10 parts Artemisia annua, 10 parts mulberry leaf, 10 parts stir-fried Atractylodes macrocephala, and 6 parts Sophora flavescens.

5. The traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The traditional Chinese medicine composition also contains pharmaceutically acceptable excipients.

6. The traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The traditional Chinese medicine composition is a topical or oral preparation.

7. The traditional Chinese medicine composition according to claim 6, characterized in that, The dosage form of the traditional Chinese medicine composition is decoction, oral liquid, granules, tablets, capsules, pills, patches, ointments, or gels.

8. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-7, characterized in that, The process includes the following steps: Take the prescribed amount of buffalo horn, add 3-5 times the total weight of the medicinal materials to water, and decoct for 15-60 minutes. After decoction, add the prescribed amounts of purslane, turmeric, isatis root, Dryopteris crassirhizoma, forsythia, Smilax glabra, gardenia, raw Sophora japonica flower, Campsis grandiflora flower, Artemisia annua, mulberry leaf, stir-fried Atractylodes macrocephala, and Sophora flavescens to the decoction. Soak for 0.5-2 hours, bring to a boil over high heat, and simmer over low heat for 15-60 minutes. Filter to obtain the decoction. Add 1-3 times the total weight of the medicinal materials to the dregs again, bring to a boil over high heat, and simmer over low heat for 10-45 minutes. Filter to obtain the decoction. Combine the two filtrates and concentrate the filtrate to a weight of 1-2 times the total weight of the medicinal materials. Optional pharmaceutically acceptable excipients can be added to obtain the final product.

9. The use of the traditional Chinese medicine composition according to any one of claims 1-7 in the preparation of a medicament for treating psoriasis.

10. The application according to claim 9, characterized in that, The psoriasis mentioned is progressive psoriasis vulgaris.

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