Optical imaging and ablation probe device based on hollow scanning reflection assembly

Abstract

The invention discloses an optical imaging and ablation probe device based on a hollow scanning reflection assembly. The optical imaging and ablation probe device comprises a first laser transmission module, a second laser transmission module, a hollow scanning reflection module and a direction switching module. The first laser transmission module and the second laser transmission module are used for generating, transmitting and regulating optical imaging laser and ablation laser. The hollow scanning reflection module is provided with a first scanning reflection mirror and a second scanning reflection mirror, reflection and scanning of an imaging laser beam and an ablation laser beam are achieved, and a scanning imaging result is used for assisting laser ablation treatment. The problems that traditional single ablation treatment lacks real-time imaging evaluation, the single-point laser ablation treatment range is small, and the problems that in an existing common-optical-path imaging auxiliary ablation treatment scheme, ablation laser energy is too high, a mirror face is prone to being damaged, and the imaging quality is reduced are solved. And the direction switching module is provided with a third reflector group and a fourth reflector group, so that the function of adjusting the direction from forward scanning to lateral scanning is added, and the requirements of different application scenes are met.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of medical imaging and ablation therapy, and particularly relates to an optical imaging and ablation probe device based on a hollow scanning reflection assembly. BACKGROUND

[0002] For the diagnosis and treatment of tumor diseases, ablation technology is widely used due to its precise positioning and minimally invasive treatment advantages. However, existing clinical imaging technology still has problems such as the inability to observe and dynamically monitor tissue changes in real time during ablation surgery, and the difficulty in accurately assessing the ablation effect, which may lead to the risk of insufficient treatment (residual) or excessive treatment (damage to healthy tissue). In traditional laser ablation technology, a fixed-point point-by-point ablation operation mode is usually adopted. When dealing with larger area lesions (such as tumor tissue), this mode needs to change the ablation site multiple times, not only significantly prolonging the single treatment time, but also increasing the risk of surrounding tissue damage and infection due to the complexity of operation, and at the same time limiting the overall improvement of treatment efficiency.

[0003] For example, traditional laser ablation technology combined with existing optical endoscopes and electronic endoscopes can effectively destroy tissue using photothermal effects after local positioning, achieving therapeutic effect; but optical endoscopes and electronic endoscopes can only observe the surface and are easily affected by reflected light of ablation laser, and cannot provide real-time imaging and feedback of three-dimensional depth information during treatment, making it difficult to dynamically assess the ablation range and ablation treatment degree. New three-dimensional optical imaging technologies such as photoacoustic, OCT, and confocal have the advantages of non-invasiveness, high resolution, and real-time structural or functional imaging, which can effectively assist laser ablation therapy. Combining photoacoustic, OCT, and confocal imaging technologies with laser ablation can achieve intraoperative precise navigation and real-time monitoring, thereby improving the precision, safety, and effectiveness of treatment.

[0004] Existing patents (Patent No. CN117462243A) report a single laser ablation technology that lacks auxiliary imaging diagnosis. Some patents (Patent No. CN115956997A) report a technology that combines laser ablation and imaging. Most of the structures in the combined imaging and ablation technology use a common light path. When two laser beams irradiate the same position of the same mirror, the high energy of the ablation laser can damage the mirror, affecting the quality of the reflected laser beam and the final imaging effect. A few structures use a non-common light path, lack scanning imaging, and are in a fixed-point ablation mode, with a single ablation position. In addition, existing reported patents are only suitable for specific scenarios such as endoscopes, and lack universality. Therefore, there is a need for the continuous development of new technologies that combine optical imaging and laser ablation. SUMMARY

[0005] This invention provides a compact and highly integrated optical imaging and ablation probe device based on a hollow scanning reflection component, addressing the problems of existing laser ablation systems, such as the inability to assess ablation effects in real time and the limited ablation range. This invention can simultaneously or sequentially achieve high-energy laser scanning ablation and high-resolution laser scanning imaging, providing real-time monitoring and dynamic treatment control in multiple application scenarios, precisely controlling the ablation intensity and range, and improving efficacy and safety.

[0006] The technical solution of the present invention is as follows:

[0007] An optical imaging and ablation probe device based on a hollow scanning reflective component, comprising:

[0008] The first laser transmission module consists of an optical imaging laser source, a first optical fiber, and a first optical mirror group;

[0009] The second laser transmission module consists of an ablation laser source, a second optical fiber, and a second optical mirror group.

[0010] The hollow scanning reflection module consists of a first scanning reflector, a second scanning reflector, and a hollow cavity.

[0011] The direction switching module consists of a third reflector and a fourth reflector;

[0012] The optical imaging laser source of the first laser transmission module emits an optical imaging laser beam, which is coupled into the first optical fiber, passes through the first optical mirror group, reaches the first scanning mirror of the hollow scanning reflection module, and after one reflection reaches the third mirror of the direction switching module, and is finally reflected to the target imaging position. The ablation laser source of the second laser transmission module emits a high-energy ablation laser beam, which is coupled into the second optical fiber, passes through the second optical mirror group, reaches the second scanning mirror of the hollow scanning reflection module, and is directly reflected to the target ablation position, or after one reflection reaches the fourth mirror of the direction switching module, and is finally reflected to the target ablation position.

[0013] Furthermore, the first scanning mirror is located at the front end of the hollow cavity, and the second scanning mirror is located at the rear end of the hollow cavity; the first and second scanning mirrors are not coaxial and are misaligned. The first and second scanning mirrors enable laser reflection and two-dimensional or three-dimensional laser scanning.

[0014] Furthermore, the direction switching module includes a third reflector and a fourth reflector. The relative positions of the third reflector and the fourth reflector in the direction switching module are set in different angle combinations to perform different combinations of imaging laser and ablation laser transmission methods. The laser beam can be focused to a specific position in front or to the side for scanning imaging and laser ablation treatment.

[0015] Further, the first optical lens group comprises a collimating lens or a focusing lens group, which forms a collimated or focused light beam to the first scanning mirror of the hollow scanning reflection module.

[0016] Further, the optical imaging laser light source is used to adjust the wavelength, working mode and power of the optical imaging laser light.

[0017] The advantages and beneficial effects of the present application are as follows:

[0018] The present application mainly proposes the concept of scanning imaging assisted laser ablation treatment and the corresponding probe structure. The hollow scanning reflection module in the structure avoids the irradiation of two laser beams to the same position of the same mirror surface, solves the problem that the ablation laser energy is too high to damage the mirror surface in the existing common optical path technology, and thus damages the quality of the reflected laser beam and reduces the final imaging effect. On the other hand, the two mirrors also have the function of two-dimensional or three-dimensional laser scanning, which can realize precise control of laser scanning imaging and laser scanning ablation, and solve the problems of small fixed-point ablation area, inability to evaluate the ablation effect, and difficulty in accurately regulating and controlling ablation in the prior art. The direction switching module in the structure can specifically adjust the relative angle of the third mirror and the fourth mirror according to the lesion position, realize lateral scanning and laser ablation or forward scanning and laser ablation, and solve the problem of single imaging field of view and insufficient flexibility of the existing combined imaging.

[0019] The device of the present application can be used in various disease application scenarios that require simultaneous (or subsequent) imaging monitoring and ablation treatment. Based on the scanning imaging result, it is beneficial to accurately evaluate the effect and range of laser ablation treatment, and it is helpful to assist in adjusting the intensity and range of ablation treatment, to realize precise disease evaluation and ablation treatment. For example, real-time monitoring and treatment of skin or internal tumors can be performed; non-invasive scanning of skin fresh red macules can be performed to locate the abnormal tissues or blood vessel network, so as to accurately ablate; for scar cancer, the cancerous tissue can be accurately identified and ablated. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 is a structure schematic diagram of a preferred embodiment provided by the present application;

[0021] Figure 2 is a schematic diagram of a hollow reflection scanning assembly;

[0022] Figure 3 is a schematic diagram of a forward scanning device.

[0023] BRIEF DESCRIPTION OF DRAWINGS

[0024] 1-First laser transmission module, 2-Second laser transmission module, 3-Hollow scanning reflection module, 4-Direction switching module, 5-Target object, 11-Optical imaging laser source, 12-First optical fiber, 13-First optical mirror group, 21-Ablation laser source, 22-Second optical fiber, 23-Second optical mirror group, 31-First scanning mirror, 32-Second scanning mirror, 33-Hollow cavity, 41-Third mirror, 42-Fourth mirror. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and thoroughly described below with reference to the accompanying drawings. The described embodiments are merely some embodiments of the present invention.

[0026] The technical solution of the present invention to solve the above-mentioned technical problems is:

[0027] like Figure 1 As shown, the optical imaging and ablation probe device based on a hollow scanning reflection component includes a first laser transmission module 1, a second laser transmission module 2, a hollow scanning reflection module 3, and a direction switching module 4. The first laser transmission module consists of an optical imaging laser source 11, a first optical fiber 12, and a first optical lens group 13.

[0028] The second laser transmission module 2 consists of an ablation laser source 21, a second optical fiber 22, and an optical mirror group 23; the hollow scanning module 3 consists of a first scanning mirror 31, a second scanning mirror 32, and a hollow cavity 33; the direction switching module 4 consists of a third mirror 41 and a fourth mirror 42.

[0029] The first laser transmission module 1 mainly completes the generation, transmission, energy control, and collimation or convergence of the optical imaging laser. The second laser transmission module 2 completes the generation, transmission, energy control, and collimation or convergence of the ablation laser. The hollow scanning reflection module 3 realizes the scanning and reflection of the two laser beams. The direction switching module 4 realizes the direction switching or multi-angle scanning imaging and ablation.

[0030] Different application scenarios have different requirements for optical imaging lasers. In order to meet the application needs of different scenarios, in some examples of optical imaging and ablation probe devices based on hollow scanning reflection components, the optical imaging laser source 11 of the first laser transmission module 1 has, but is not limited to, confocal, OCT and photoacoustic imaging laser sources.

[0031] Different tissues respond differently to lasers. For example, in photoacoustic imaging, hemoglobin absorbs 532 nm laser light more strongly. To achieve clearer imaging of different tissues, in some examples of optical imaging and ablation probe devices based on hollow scanning reflective components, the wavelength, operating mode, and power of the optical imaging laser source 11 are adjustable.

[0032] In some examples of the optical imaging and ablation probe device based on the hollow scanning reflection assembly, the first optical lens group 13 and the second optical lens group 23 can be a lens combination commonly used in the field of optical imaging, and the purpose is to achieve focusing or collimation, and the type is not particularly required.

[0033] In some examples of the optical imaging and ablation probe device based on the hollow scanning reflection assembly, the structure of the hollow cavity 33 of the hollow scanning reflection module is not limited, and the purpose is to avoid two beams of light irradiating the same position of the mirror, thereby causing damage to the mirror, and the second purpose is to achieve reflection of the imaging laser and the ablation laser, two-dimensional or three-dimensional scanning control, to achieve scanning imaging and evaluation of the ablation effect, thereby assisting laser ablation treatment.

[0034] In some examples of the optical imaging and ablation probe device based on the hollow scanning reflection assembly, the hollow scanning reflection module 3 can be a displacement platform driving the hollow cavity to mechanically scan, can be a galvanometer mirror scanning, or can be that both the first scanning mirror 31 and the second scanning mirror 32 are MEMS micro mirrors.

[0035] The direction switching module 4 can realize direction switching, multi-angle scanning imaging and ablation by changing the reflection angles of the third mirror 41 and the fourth mirror 42. In some examples of the optical imaging and ablation probe device based on the hollow scanning reflection assembly, the direction switching module 4 realizes lateral scanning Figure 1 and forward scanning Figure 3 .

[0036] The systems, devices, modules or units illustrated in the above examples can be specifically implemented by computer chips or entities, or by products with certain functions.

[0037] It should be further noted that the terms “comprising” or “including” or any other variant thereof are intended to cover non-exclusive inclusion, so that processes, methods, articles or devices that include a series of elements not only include those elements, but also include other elements that are not explicitly listed, or further include elements inherent in such processes, methods, articles or devices. Without more limitations, the element defined by the statement “comprising a” does not exclude the presence of additional identical elements in the process, method, article or device that includes the element.

[0038] The above examples are to be understood as merely illustrative of the present application and not a limitation of the scope of protection of the present application. After reading the content of the specification of the present application, those skilled in the art can make various modifications or changes to the present application, and these equivalent changes and modifications also fall within the scope defined by the claims of the present application.

Claims

1. An optical imaging and ablation probe apparatus based on a hollow scanning reflective assembly, characterized by, The application relates to a laser transmission module for generating, transmitting and regulating optical imaging laser and ablation laser. The hollow scanning reflection module is internally provided with first and second scanning mirror groups which are independent of each other and have separated light paths, is used for receiving, reflecting and two-dimensionally or three-dimensionally scanning the optical imaging laser and the ablation laser, realizes the collaborative work of high-quality imaging and high-efficiency ablation in a probe, that is, scanning imaging assists laser ablation treatment. The direction switching module is composed of third and fourth mirrors which are placed at different positions and have different angles, and is used for regulating and switching the final emission directions of the imaging laser beam and the ablation laser beam. By adjusting the relative positions and deflection angles of the third mirror in the imaging light path and the fourth mirror in the ablation light path in the direction switching module, the final emission directions of the imaging laser and the ablation laser can be independently changed, the probe device can be switched between forward scanning and lateral scanning, and different lesions in different forms and positions can be adapted. By adjusting the driving voltage, scanning mode and scanning angle of the scanning mirror groups in the hollow scanning reflection module and the relative positions and deflection angles of the corresponding mirrors in the imaging light path and the ablation light path in the direction switching module, the imaging laser and the ablation laser can be collaboratively worked in a target region, that is, after the imaging laser identifies a lesion, the ablation laser can act on the same or adjacent region according to requirements, so that precise imaging and treatment are realized. The hollow scanning reflection module comprises a hollow cavity, a first scanning mirror at the front end of the cavity and a second scanning mirror which is placed in space dislocation with the first scanning mirror at the rear end of the cavity.

2. The hollow scanning-reflecting assembly based optical imaging and ablation probe device of claim 1, wherein, The third mirror and the fourth mirror are placed in dislocation at a certain angle and can be independently adjusted in deflection angle.

3. The hollow scanning-reflecting assembly based optical imaging and ablation probe apparatus of claim 1, wherein, The laser transmission module comprises:

4. The hollow scanning-reflecting assembly based optical imaging and ablation probe device of claim 1, wherein, The first laser transmission module is sequentially connected by an optical imaging laser light source, a first optical fiber and a first optical mirror group, is used for generating, transmitting and regulating the imaging laser, and the second laser transmission module is sequentially connected by an ablation laser light source, a second optical fiber and a second optical mirror group, is used for generating, transmitting and regulating the ablation laser. The optical imaging laser light source adjusts the wavelength, working mode and power of the optical imaging laser. The first optical mirror group forms a collimated light beam or a convergent light beam and is incident to the first scanning mirror of the hollow reflection scanning system.

5. The hollow scanning-reflecting assembly based optical imaging and ablation probe device of claim 4, wherein, The ablation treatment laser light source adjusts the wavelength, working mode and power of the ablation laser.

6. The hollow scanning-reflecting assembly based optical imaging and ablation probe apparatus of claim 4, wherein, The second optical mirror group forms a collimated light beam or a convergent light beam and is incident to the second scanning mirror of the hollow reflection scanning system.

7. The hollow scanning-reflecting assembly based optical imaging and ablation probe device of claim 4, wherein, ​ 8. The hollow scanning-reflecting assembly based optical imaging and ablation probe device of claim 4, wherein, ​

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