Children eye protection herbal composition for relieving asthenopia and preparation method, application and product thereof

Abstract

The invention discloses a child eye protection herbal composition for relieving asthenopia and a preparation method, application and a product thereof, and belongs to the technical field of foods.The child eye protection herbal composition is prepared from, by weight, 1-12 parts of chrysanthemum, 0.5-18 parts of fructus lycii, 0.2-10 parts of semen cassiae, 0.4-12 parts of folium mori, 0.9-18 parts of fructus corni, 0.3-6 parts of herba dendrobii and 1-12 parts of radix rehmanniae praeparata. The ratio of the total weight of the semen cassiae and the folium mori to the total weight of the fructus corni and the herba dendrobii is (0.5-1): 1. On the basis of the theory of homology of medicine and food, various medicinal and edible plants with the eye protection effect are scientifically combined to play a synergistic role, the effect of relieving asthenopia is remarkably improved, and the adopted traditional Chinese medicine raw materials are all medicinal and edible plants, are good in safety and low in side effect, and are suitable for being taken by asthenopia people for a long time, especially children.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of food technology, and in particular relates to a child eye-protecting herbal composition for relieving visual fatigue, a preparation method, application and product thereof. BACKGROUND

[0002] Visual fatigue, also known as eye strain, is a kind of eye fatigue syndrome caused by overuse of eyes during long-time close work or study. Visual fatigue mainly includes blurred vision, ghosting, photophobia, intolerance to vision, dryness, itching, soreness, swelling, tearing, headache and dizziness, which seriously affects the quality of work, study and life. With the rapid development of the Internet, computers, mobile phones and other electronic products have become indispensable tools in modern life and office work. Long-time watching of electronic products and the influence of physical and mental stress lead to overuse of eyes and visual fatigue, which is becoming more and more common.

[0003] Visual fatigue belongs to the category of "liver strain" in traditional Chinese medicine ophthalmology. The eye is the aperture of the liver, and is born in the kidney and used in the heart. The pathogenesis is mainly related to the liver, heart and kidney. Visual fatigue is mainly caused by overuse of eyes, damage to the spirit, damage to the spleen and consumption of qi, or overuse of eyes, consumption of liver and kidney essence and blood, and inability to nourish the eye aperture. It is closely related to the spleen, liver, kidney, qi and blood. Clinically, drugs for tonifying qi, invigorating the spleen, soothing the liver, tonifying the kidney and nourishing the blood are commonly used for prevention and treatment. It is a research focus to develop functional foods for relieving visual fatigue by using plants with medicinal and edible properties as main raw materials. For example, Chinese patent application CN201510390503.9 discloses a health-care traditional Chinese medicine composition for preventing and improving visual fatigue, which is composed of Cuscuta chinensis Lam., Lycium barbarum L., female privet fruit steamed with wine, Eclipta prostrata L., Phaseolus lunatus L., Polygonatum sibiricum, Chrysanthemum morifolium Ramat., fried Cassia obtusifolia L., Poria cocos, Pericarpium Citri Reticulatae, Pueraria lobata Ohwi and Chaenomeles sinensis. The composition has the functions of nourishing the liver and kidney, clearing the liver and improving eyesight, and regulating meridians, and is mainly used for liver deficiency, qi, blood, fluid and essence failing to nourish the eyes, thereby preventing and improving liver strain (visual fatigue).

[0004] Chinese patent application CN201910711628.5 discloses a traditional Chinese medicine composition for relieving visual fatigue, which is prepared from longan aril, Lycium barbarum L., mulberry, Dendrobium, chamomile, black sesame, lily and Polygonatum sibiricum. The traditional Chinese medicine composition has obvious relieving effect on eye symptoms such as visual dimness, eye swelling, dryness, burning pain, and acid pain in the eyes and eye sockets caused by visual fatigue.

[0005] At present, there are relatively few compositions for relieving visual fatigue developed by using plants with medicinal and edible properties as main raw materials. Therefore, it is necessary to study a child eye-protecting herbal composition for relieving visual fatigue. SUMMARY

[0006] To solve the above technical problems, the present application provides a kind of children's eye protection herbal composition for relieving visual fatigue and its preparation method, application and product.The children's eye protection herbal composition is based on the theory of food and medicine homology, and a plurality of food and medicine homology plants with eye protection efficacy are scientifically matched to play a synergistic effect, which significantly improves the effect of relieving visual fatigue.

[0007] To achieve the above-mentioned purpose, the present application adopts the following technical solutions: In the first aspect, the present application provides a kind of children's eye protection herbal composition for relieving visual fatigue, which comprises the following raw materials: chrysanthemum, medlar, cassia seed, mulberry leaf, cornus officinalis, dendrobium and prepared rehmannia.

[0008] The formula of the children's eye protection herbal composition is: Chrysanthemum: sweet, bitter, slightly cold, belongs to lung and liver meridians, has the effects of dispelling wind and clearing heat, calming liver and improving eyesight, clearing heat and detoxifying; Medlar: sweet, belongs to liver and kidney meridians, has the effects of nourishing liver and kidney, benefiting essence and improving eyesight; Cassia seed: sweet, bitter, salty, slightly cold, belongs to liver and large intestine meridians, has the effects of clearing heat and improving eyesight, moistening intestines and relieving constipation; Mulberry leaf: bitter, sweet, cold, belongs to lung and liver meridians, has the effects of dispersing wind and heat, clearing lung and moistening dryness, calming liver and improving eyesight, cooling blood and stopping bleeding; Cornus officinalis: sour, astringent, slightly warm, belongs to liver and kidney meridians, has the effects of tonifying liver and kidney, astringing and consolidating; Dendrobium: sweet, slightly cold, belongs to stomach and kidney meridians, has the effects of benefiting stomach and generating fluid, nourishing yin and clearing heat; Prepared rehmannia: sweet and warm, belongs to kidney meridian, has the effects of tonifying liver and kidney, nourishing yin and filling essence.

[0009] The children's eye protection herbal composition of the present application is matched according to the principle of "clearing liver and nourishing liver, benefiting kidney and protecting spleen": the monarch drug chrysanthemum and medlar are clear and tonifying, which lay the foundation for eye protection; The ministerial drug mulberry leaf and cassia seed enhance the ability of clearing liver and improving eyesight, and also relieve heat through bowel; The auxiliary drug cornus officinalis and dendrobium nourish kidney and liver, protect spleen and nourish stomach, and restrict the cold and cool nature; The ministerial drug prepared rehmannia regulates the nature of drugs and leads the meridians to viscera. The whole prescription has mild nature, tonifying without greasiness, clearing without harshness, which not only fits the physiological characteristics of tender children's viscera, but also relieves visual fatigue in multiple dimensions (clearing heat and dryness, nourishing yin and moistening eyes, regulating qi movement), achieving the dual effects of "treating symptoms (relieving dry eyes and dry eyes) + treating root cause (nourishing liver, spleen and kidney, reducing recurrence of visual fatigue)".

[0010] In some embodiments, the children's eye protection herbal composition comprises the following raw materials by weight: chrysanthemum 1-12 parts, medlar 0.5-18 parts, cassia seed 0.2-10 parts, mulberry leaf 0.4-12 parts, cornus officinalis 0.9-18 parts, dendrobium 0.3-6 parts and prepared rehmannia 1-12 parts.

[0011] Preferably, the child eye-protecting herbal composition comprises, by weight, chrysanthemum 8-12 parts, medlar 12-18 parts, cassia seed 6-10 parts, mulberry leaf 8-12 parts, dogwood 12-18 parts, dendrobium 4-6 parts, and rehmannia 8-12 parts.

[0012] Further preferably, the child eye-protecting herbal composition comprises, by weight, chrysanthemum 10 parts, medlar 15 parts, cassia seed 8 parts, mulberry leaf 10 parts, dogwood 15 parts, dendrobium 5 parts, and rehmannia 10 parts.

[0013] In some embodiments, the total weight of the cassia seed and the mulberry leaf is 0.5-1 times the total weight of the dogwood and the dendrobium; preferably 0.9:1.

[0014] In some embodiments, the weight ratio of the cassia seed and the mulberry leaf is 0.5-1:1; preferably 0.8:1.

[0015] In some embodiments, the weight ratio of the dogwood and the dendrobium is 3:1.

[0016] The present application further adds lutein ester and concentrated blueberry puree to the above-mentioned child eye-protecting herbal composition to further improve the effect of relieving visual fatigue.

[0017] In some embodiments, the child eye-protecting herbal composition comprises, by weight, chrysanthemum 1-12 parts, medlar 0.5-18 parts, cassia seed 0.2-10 parts, mulberry leaf 0.4-12 parts, dogwood 0.9-18 parts, dendrobium 0.3-6 parts, and rehmannia 1-12 parts, lutein ester 0.001-0.05 parts, and concentrated blueberry puree 1-12 parts.

[0018] Preferably, the child eye-protecting herbal composition comprises, by weight, chrysanthemum 10 parts, medlar 15 parts, cassia seed 8 parts, mulberry leaf 10 parts, dogwood 15 parts, dendrobium 5 parts, and rehmannia 10 parts, lutein ester 0.03 parts, and concentrated blueberry puree 10 parts.

[0019] In the second aspect, the present application provides a preparation method of the above-mentioned child eye-protecting herbal composition, comprising the following steps: (1) water extraction of the formula amount of chrysanthemum, medlar, cassia seed, mulberry leaf, dogwood, dendrobium, and rehmannia, solid-liquid separation, concentration of the extraction liquid, to obtain a clear paste; (2) adding the formula amount of lutein ester and concentrated blueberry puree into the clear paste and mixing uniformly.

[0020] In some embodiments, the water extraction is decocting with water at least once, preferably 2-4 times, further preferably 2-3 times; each time of water extraction is 0.5-3h, preferably 0.5-2h, further preferably 1-2h.

[0021] In some embodiments, the water is added in an amount of 8-15 times, preferably 9-12 times, of the total weight of the chrysanthemum, medlar, cassia seed, mulberry leaf, cornus officinalis, dendrobium and prepared rehmannia.

[0022] In some embodiments, the concentration is concentrated to a relative density of 1.15-1.20 (50℃).

[0023] In a third aspect, the present application provides use of the above-mentioned eye-protecting herbal composition for children or the eye-protecting herbal composition for children prepared by the above-mentioned preparation method in the preparation of a functional food or a medicine for relieving visual fatigue.

[0024] In a fourth aspect, the present application provides a product for relieving visual fatigue, comprising the above-mentioned eye-protecting herbal composition for children or the eye-protecting herbal composition for children prepared by the above-mentioned preparation method.

[0025] The eye-protecting herbal composition for children of the present application can be used as a raw material for the preparation of a functional food or a medicine. Based on this, the product can be a functional food or a medicine.

[0026] As a functional food, the dosage form of the product is a paste, a tablet, a powder, a granule, a capsule, an oral solution, a pill, a wine or a beverage. The functional food can add at least one of a health-care product-acceptable excipient, such as a sweetening agent, an acid adjusting agent, a filling agent, a flavoring agent, a coloring agent, an antioxidant, a thickening agent, a stabilizer, an emulsifying agent, an anti-caking agent, a flow aid and a lubricant, according to the actual production requirements of the dosage form.

[0027] As a medicine, the dosage form of the product is a tablet, a capsule, a granule, a pill, a powder, a syrup, an oral solution, an oral suspension, an oral emulsion or a mixture. The medicine can add at least one of a pharmaceutically acceptable excipient, such as an inert diluent, a dispersing agent, a gas-producing agent, a filling agent, a disintegrating agent, a binding agent, a plasticizing agent, an anti-sticking agent, a wetting agent, a lubricant, a solvent, a suspending agent, a solubilizing agent, a buffering agent, an emulsifying agent, a preservative, an antioxidant, a thickening agent, a stabilizer, a coloring agent, a coating agent, a sweetening agent and a flavoring agent, according to the actual production requirements of the dosage form.

[0028] The present application has the following advantages: 1. The herbal composition for children's eye protection of the present invention is formulated based on the principle of "clearing and nourishing the liver, benefiting the kidneys and protecting the spleen": the principal herbs, chrysanthemum and wolfberry, clear and nourish respectively, laying the foundation for eye protection; the assistant herbs, mulberry leaf and cassia seed, enhance the ability to clear the liver and improve eyesight, while also clearing heat from the intestines; the adjuvant herbs, cornus officinalis and dendrobium, nourish the kidneys and liver, protect the spleen and stomach, and counteract the cold and cooling properties; the guiding herb, rehmannia glutinosa, harmonizes the medicinal properties and guides the medicine to the organs. The entire formula is mild in nature, nourishing without being greasy and clearing without being harsh, which not only meets the physiological characteristics of children's delicate organs, but also relieves eye fatigue from multiple dimensions (clearing heat and relieving dryness, nourishing yin and moistening the eyes, and regulating qi), achieving the dual effect of "treating the symptoms (relieving dry and itchy eyes) + treating the root cause (nourishing the liver, spleen and kidneys, and reducing the recurrence of eye fatigue)".

[0029] 2. Based on the theory of food and medicine being of the same origin, this invention scientifically combines various food and medicine plants with eye-protecting effects. Experiments have shown that the combination of these plants is scientific and synergistic, which can significantly improve the effect of relieving eye fatigue.

[0030] 3. Based on the principle of food and medicine being of the same origin, this invention combines lutein ester and concentrated blueberry puree, which can increase the special nutrients required by the visual system, promote blood circulation around the visual system, and accelerate liver metabolism, thereby reducing eye fatigue and delaying the onset of myopia.

[0031] 4. This invention is based on the theory of food and medicine sharing the same origin. All the Chinese medicinal materials used are plants that are both food and medicine, which have good safety and low side effects. They are suitable for long-term use by people with eye fatigue, especially children. Detailed Implementation

[0032] The following description of the embodiments is merely to aid in understanding the method and core ideas of the present invention. It should be noted that those skilled in the art can make various modifications and improvements to the present invention without departing from its principles, and these modifications and improvements also fall within the scope of the claims. The following description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not limited to the embodiments shown herein, but can be applied to a wider scope consistent with the principles and novel features disclosed herein. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains.

[0033] This invention does not limit the source of the raw materials used. Unless otherwise specified, all raw materials used in this invention are commercially available products commonly used in this technical field. The concentrated blueberry puree was purchased from Anhui Yimingtang Biotechnology Co., Ltd. (6970498790292).

[0034] Example 1-3 and Comparative Example 1-3 Child eye protection herbal composition The raw materials were weighed according to Table 1, and the child eye protection herbal composition of the corresponding example or comparative example was prepared by the following preparation method.

[0035] The preparation method is as follows: (1) The formula amount of chrysanthemum, medlar, cassia seed, mulberry leaf, dogwood, dendrobium officinale and prepared rehmannia were decocted twice with water, the water was added in an amount of 10 times the total weight of chrysanthemum, medlar, cassia seed, mulberry leaf, dogwood, dendrobium officinale and prepared rehmannia, the decoction time was 1 h, the filtrates were combined and filtered, and concentrated to a relative density of 1.15-1.20 (50°C) to obtain a clear paste.

[0036] (2) The clear paste was mixed with the formula amount of lutein ester and concentrated blueberry syrup to obtain the child eye protection herbal composition.

[0037] Table 1

[0038] The child eye protection herbal composition provided by the application was subjected to functional evaluation of relieving visual fatigue according to Health Food Function Test and Evaluation Method (2023 Edition).

[0039] Inclusion criteria: children aged 6-12 years; ≥3 hours of near vision use per day (including reading, writing homework, and using electronic products); naked visual acuity or corrected visual acuity ≥4.8; guardian informed consent. Exclusion criteria: suffering from eye diseases (such as conjunctivitis, keratitis, glaucoma, etc.); suffering from serious systemic diseases (such as heart disease, liver and kidney dysfunction, etc.); allergic constitution; taking other drugs that may affect vision; poor compliance and unable to complete the test.

[0040] Randomized, the experiment was divided into 7 groups, blank control group, example 1-example 3 group and comparative example 1-comparative example 3 group, 50 people in each group. Example 1-Example 3 and Comparative Example 1-Comparative Example 3 were administered with the child eye protection herbal composition prepared according to the corresponding example or comparative example, 10g per day, once a day, and the blank control group was administered with the same amount of normal saline, for 30 consecutive days.

[0041] 1. Effective rate of symptom improvement According to the efficacy judgment standard, the improvement of symptoms, effectiveness and ineffectiveness were investigated. The effective rate of symptom improvement = (number of cases with improved symptoms) x 100% / total number of cases. The results are shown in Table 2.

[0042] Table 2

[0043] 2. Duration of clear vision The percentage of the photopic time to the fixation time is called photopic duration; a "pin" shaped stereoscopic block diagram is drawn on the check table, the block is 1cm long on each side, and the local illumination is 120LX. The distance between the check table and the eye should be kept at a proper distance without moving according to the viewing habit of the subject, and it is stipulated that the subject sees the "pin" image as photopic, and sees the inverted "pin" as non-photopic, and the determination time is 3 minutes. Photopic duration = (photopic time / total fixation time) x 100%. The results are shown in Table 3.

[0044] Table 3

[0045] In summary, the child eye-protecting herbal composition provided by the embodiments 1-3 of the present application has the effect of relieving visual fatigue.

[0046] Meanwhile, comparing the comparative examples 1-3 and the embodiment 1, it can be seen that the ratio of the total weight of the Cassia seed and the mulberry leaf to the total weight of the Cornus officinalis and the Dendrobium, the weight ratio of the Cassia seed and the mulberry leaf, and the weight ratio of the Cornus officinalis and the Dendrobium all have important influences on relieving visual fatigue, and none of them can be omitted. The present application utilizes the ratio of the total weight of the Cassia seed and the mulberry leaf to the total weight of the Cornus officinalis and the Dendrobium, the weight ratio of the Cassia seed and the mulberry leaf, and the weight ratio of the Cornus officinalis and the Dendrobium to cooperate with each other in relieving visual fatigue, and unexpected technical effects are produced.

[0047] The above is a further description of the present application in combination with specific embodiments, but these embodiments are only exemplary and do not constitute any limitation on the scope of the present application. Those skilled in the art should understand that the details and forms of the technical solutions of the present application can be modified or replaced without deviating from the spirit and scope of the present application, and these modifications and replacements all fall within the protection scope of the present application.

Claims

1. A herbal composition for relieving eye strain in children, characterized in that, The ingredients, by weight, include the following: 1-12 parts chrysanthemum, 0.5-18 parts wolfberry, 0.2-10 parts cassia seed, 0.4-12 parts mulberry leaf, 0.9-18 parts cornus officinalis, 0.3-6 parts dendrobium, and 1-12 parts prepared rehmannia root. The ratio of the total weight of cassia seeds and mulberry leaves to the total weight of cornus officinalis and dendrobium is 0.5-1:

1.

2. The herbal composition for children's eye protection according to claim 1, characterized in that, The ratio of the total weight of cassia seeds and mulberry leaves to the total weight of cornus officinalis and dendrobium was 0.9:

1.

3. The herbal composition for children's eye protection according to claim 1, characterized in that, The weight ratio of cassia seeds to mulberry leaves is 0.5-1:1; preferably 0.8:

1.

4. The herbal composition for children's eye protection according to claim 1, characterized in that, The weight ratio of Cornus officinalis to Dendrobium nobile is 3:

1.

5. The herbal composition for children's eye protection according to claim 1, characterized in that, By weight, it includes the following ingredients: chrysanthemum 8-12 parts, wolfberry 12-18 parts, cassia seed 6-10 parts, mulberry leaf 8-12 parts, cornus officinalis 12-18 parts, dendrobium 4-6 parts and prepared rehmannia root 8-12 parts.

6. The herbal composition for children's eye protection according to claim 1, characterized in that, It includes 0.001-0.05 parts by weight of lutein ester and 1-12 parts of concentrated blueberry puree.

7. The herbal composition for children's eye protection according to claim 6, characterized in that, By weight, it includes the following ingredients: 10 parts chrysanthemum, 15 parts wolfberry, 8 parts cassia seed, 10 parts mulberry leaf, 15 parts cornus officinalis, 5 parts dendrobium, 10 parts prepared rehmannia root, 0.03 parts lutein ester, and 10 parts concentrated blueberry puree.

8. A method for preparing the herbal composition for children's eye protection according to any one of claims 1-7, characterized in that, The process includes the following steps: decocting the prescribed amounts of chrysanthemum, wolfberry, cassia seed, mulberry leaf, cornus officinalis, dendrobium, and prepared rehmannia root in water, separating the solid and liquid components, concentrating the extract, and obtaining a clear paste.

9. The use of the herbal composition for children's eye care according to any one of claims 1-7 or the herbal composition for children's eye care prepared by the preparation method according to claim 8 in the preparation of products for relieving eye fatigue, characterized in that, The product is a functional food or a medicine.

10. A children's eye care product for relieving eye strain, characterized in that, It is made from the herbal composition for children's eye care according to any one of claims 1-7 or the preparation method according to claim 8, and food or pharmaceutically acceptable excipients.

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