Paste dressing for invigorating spleen, replenishing qi and removing stagnation as well as preparation method and application of paste dressing

Abstract

The invention discloses a paste dressing for invigorating spleen, replenishing qi and removing stagnation as well as a preparation method and application of the paste dressing. The active effective components of the paste dressing comprise the following components: lindera aggregata, radix angelicae, pepper, processed rhizoma typhonii, rhizoma zingiberis, ligusticum wallichii, elecampane and caulis spatholobi. The paste dressing disclosed by the invention has an excellent transdermal treatment effect through transdermal drug delivery, and has a good treatment effect on symptoms such as abdominal distension, abdominal distension of gastric mass diseases and constipation of patients with chronic gastritis in cooperation with a stone needle ironing therapy.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine external products, in particular to a paste-shaped dressing for invigorating the spleen and replenishing qi and removing stagnation and a preparation method and application thereof. BACKGROUND

[0002] In contemporary society, the pace of life has accelerated dramatically, and people's eating and living habits have changed significantly. This change has led to an increasing number of people with spleen and stomach dysfunction. Chronic digestive disorders, such as abdominal distension, loss of appetite, and fatigue caused by spleen deficiency and qi stagnation, are common clinical conditions.

[0003] In the existing medical system, western medicine plays an important role in alleviating the above symptoms due to its rapid onset. However, western medicine treatment often has side effects that cannot be ignored. Long-term or improper use of western medicine not only weakens the body's self-regulating ability, but also can cause other adverse reactions, such as increased drug resistance, liver and kidney function damage, and other health risks, further exacerbating the patient's health risks.

[0004] Given the limitations of western medicine treatment, clinical nursing is increasingly important in regulating the function of the spleen and stomach and improving related symptoms. Among them, invigorating the spleen and replenishing qi and removing stagnation is the core concept of clinical nursing, which regulates the spleen and stomach qi, and enhances the function of the spleen and stomach, achieving the purpose of fundamentally improving digestive disorders. The organic combination of clinical nursing and clinical treatment not only effectively reduces the amount of western medicine used, but also improves the treatment effect and promotes the overall recovery of patients.

[0005] In clinical nursing practice, dressings are a key means that are favored due to their small size, good stability, simple operation, and easy storage. Dressings can directly act on the affected area, continuously release active ingredients or provide physical support, promote local blood circulation, and accelerate tissue repair, thereby effectively relieving various uncomfortable symptoms caused by spleen and stomach dysfunction. Therefore, providing a spleen-invigorating, qi-replenishing, and stagnation-removing dressing for clinical nursing is of great significance to meet clinical needs and improve the quality of life of patients. SUMMARY

[0006] In view of the increasingly serious problem of spleen and stomach dysfunction caused by the accelerated pace of life in contemporary society, as well as the side effects and limitations of existing western medicine treatment, the present application aims to provide a novel paste-shaped dressing for invigorating the spleen and replenishing qi and removing stagnation, which is expected to break through the limitations of traditional oral dosage forms by utilizing skin penetration technology to enhance the absorption efficiency and bioavailability of active ingredients in the body, thereby achieving the effects of invigorating the spleen, replenishing qi, and relieving gastrointestinal discomfort.

[0007] The present application relates to the following content:

[0008] 1. A paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation, wherein the paste-like dressing comprises an active ingredient and a matrix, the active ingredient comprising the following components: Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0009] 2. The ointment dressing according to item 1, wherein the active ingredients comprise the following components by weight: 0.1-10 parts of Lindera strychnifolia, 1-15 parts of Angelica dahurica, 1-15 parts of Zanthoxylum bungeanum, 0.01-5 parts of processed Aconitum carmichaelii, 0.1-10 parts of dried ginger, 0.1-10 parts of Ligusticum chuanxiong, 0.1-10 parts of Aucklandia lappa, and 0.1-10 parts of Spatholobus suberectus;

[0010] Preferably, the active ingredients include the following components by weight: 2 parts of Lindera strychnifolia, 4 parts of Angelica dahurica, 4 parts of Zanthoxylum bungeanum, 1 part of processed Aconitum carmichaelii, 2 parts of dried ginger, 2 parts of Ligusticum chuanxiong, 2 parts of Aucklandia lappa, and 2 parts of Spatholobus suberectus.

[0011] 3. The ointment dressing according to item 1, wherein the mass ratio of the active ingredient to the matrix is ​​1:(1-10); preferably 1:1;

[0012] And / or, wherein the matrix comprises petrolatum and paraffin oil;

[0013] Preferably, the matrix is ​​petrolatum and paraffin oil;

[0014] More preferably, the mass of the paraffin oil is 1 to 50 wt% of the sum of the mass of the active ingredient and the petrolatum; preferably 10 wt%.

[0015] 4. A method for preparing the ointment dressing described in any one of items 1-3, comprising:

[0016] The active ingredients are pulverized separately and then mixed according to the prescription ratio to obtain a mixed fine powder.

[0017] The matrix is ​​heated until completely melted, and the mixed fine powder is then homogenized with the molten matrix.

[0018] Cooling yields a paste-like dressing.

[0019] Preferably, the active ingredients are pulverized to 100-300 mesh; more preferably, to 200 mesh.

[0020] 5. According to the preparation method described in item 4, the temperature at which the matrix is ​​heated is 60–90°C; and / or,

[0021] The temperature for mixing and homogenizing is 50–80°C.

[0022] Preferably, the mixed fine powder is added to the molten matrix in two, three, four or more batches.

[0023] Preferably, stirring is maintained continuously during the cooling process;

[0024] The stirring rate during the cooling process is 100-140 rpm.

[0025] 6. According to the preparation method described in item 4 or 5, the cooling process includes a first cooling stage and a second cooling stage, wherein the cooling rate of the first cooling stage is greater than the cooling rate of the second cooling stage;

[0026] Preferably, the cooling rate in the first cooling stage is 0.8–1.5 °C / min; and / or

[0027] The cooling rate in the second cooling stage is 0.2–0.7 °C / min;

[0028] Preferably, during the first cooling stage, the temperature is reduced to 42–48°C; and / or

[0029] During the first cooling phase, the temperature is reduced to 25–30°C.

[0030] 7. The use of the ointment dressing described in any one of items 1 to 3 or the ointment dressing prepared by any one of the preparation methods in items 4 to 6 in the preparation of a percutaneous medical device, wherein the percutaneous medical device includes a carrier and the ointment dressing loaded on the carrier;

[0031] Preferably, the carrier is selected from any one or more of medical nonwoven fabric, polymer film, silicone substrate, metal foil, polymer foil or pressure-sensitive adhesive patch;

[0032] More preferably, the surface of the carrier layer is physically or chemically treated to enhance the adhesion of the ointment dressing.

[0033] In one embodiment, the ointment dressing includes an active ingredient and a matrix, wherein the active ingredient includes the following components: Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0034] In one embodiment, the active ingredients include the following components by weight: 2 parts of Lindera strychnifolia, 4 parts of Angelica dahurica, 4 parts of Zanthoxylum bungeanum, 1 part of processed Aconitum carmichaelii, 2 parts of dried ginger, 2 parts of Ligusticum chuanxiong, 2 parts of Aucklandia lappa, and 2 parts of Spatholobus suberectus.

[0035] 8. A percutaneous therapeutic medical device, wherein the medical device comprises a carrier and a paste dressing described in any one of items 1 to 3 loaded on the carrier, or a paste dressing prepared by any one of items 4 to 6.

[0036] 9. A nursing care kit, wherein the nursing care kit includes a matching ironing and rubbing stone, and a paste dressing as described in any one of items 1 to 3 or a paste dressing prepared by any one of items 4 to 6;

[0037] Preferably, the ironing stone has an integrated heating element inside;

[0038] The heating element regulates the surface temperature of the Bian stone to 55-65°C through resistance heating.

[0039] Preferably, the ointment dressing comprises an active ingredient and a matrix, wherein the active ingredient comprises the following components: Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0040] Preferably, the active ingredients include the following components by weight: 2 parts of Lindera strychnifolia, 4 parts of Angelica dahurica, 4 parts of Zanthoxylum bungeanum, 1 part of processed Aconitum carmichaelii, 2 parts of dried ginger, 2 parts of Ligusticum chuanxiong, 2 parts of Aucklandia lappa, and 2 parts of Spatholobus suberectus.

[0041] Preferably, the mineral composition of the ironing stone includes silicon dioxide (SiO2), calcium oxide (CaO), and trace elements iron (Fe) and zinc (Zn);

[0042] More preferably, the material of the ironing stone is selected from Sishui Bian stone, Xiuyan jade or basalt.

[0043] Preferably, the surface of the ironing stone is treated with a nano-coating to enhance its affinity with the ointment dressing.

[0044] 10. According to the nursing kit described in item 9, the method of using the ironing stone and the ointment dressing together includes:

[0045] First, apply a cream-like dressing to the skin surface, then use a Bian stone for targeted ironing and massage; and / or,

[0046] A paste-like dressing is pre-coated onto the surface of the Bian stone, and simultaneous drug delivery and physiotherapy are achieved through heating and / or pressure.

[0047] 11. According to the nursing kit described in item 9, the ironing stone synergizes with the ointment dressing in the following way:

[0048] The far-infrared radiation of Bian stone expands skin pores, accelerating drug absorption;

[0049] The thermal conductivity of Bian stone helps maintain the thermal stability of the active ingredients in traditional Chinese medicine ointments.

[0050] The mechanical pressure from Bian stone massage promotes local blood circulation.

[0051] The beneficial effects of this application are as follows:

[0052] This application provides a traditional Chinese medicine ointment formulation. The active ingredients in this ointment can penetrate into the bloodstream through the stratum corneum, hair follicles, and sebaceous glands of the skin, avoiding the destruction by digestive enzymes and gastric acid during the gastrointestinal tract and the first-pass effect of the liver, thus improving the bioavailability of the drug. It has a significant improving effect on various symptoms caused by spleen and stomach dysfunction, such as loss of appetite, abdominal distension, indigestion, fatigue, and constipation. By strengthening the spleen, replenishing qi, and promoting digestion, it can enhance the digestive function of the spleen and stomach, promote the digestion and absorption of food, increase the body's nutrient intake and energy supply, thereby improving the patient's overall health. Attached Figure Description

[0053] Figure 1 BPI chromatogram for identifying positive and negative ions in aqueous decoction (top: positive ion, bottom: negative ion).

[0054] Figure 2 BPI chromatograms for identifying positive and negative ions in ointments (top: positive ions, bottom: negative ions). Detailed Implementation

[0055] The following description provides exemplary embodiments of this application, including various details to aid understanding, and should be considered merely exemplary. Therefore, those skilled in the art will recognize that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of this application. Similarly, for clarity and brevity, descriptions of well-known functions and structures are omitted in the following description.

[0056] This application provides a paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation. The paste-like dressing includes active ingredients and a matrix. The active ingredients include the following components: Lindera root, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0057] Among them, Lindera root has the effects of warming the middle jiao and dispelling cold, promoting qi circulation and relieving pain, and is used for symptoms such as spleen and stomach deficiency and cold, and qi stagnation and pain; Angelica dahurica dispels wind and dampness, and promotes transdermal penetration; Angelica dahurica's volatile oil (such as angelicin) can dilate skin capillaries and enhance drug permeability; Zanthoxylum bungeanum has the effects of warming the middle jiao and relieving pain, and has antibacterial and anti-inflammatory properties, and is used for cold-damp abdominal pain, eczema and itching; Prepared Aconitum carmichaelii has the effects of warming yang and dispelling cold, and dispelling wind and relieving pain, and is used for cold-damp arthralgia, joint pain, etc.; Dried ginger has the effects of warming the middle jiao and dispelling cold, and restoring yang and unblocking the meridians, and is used for spleen and stomach deficiency and cold, vomiting and diarrhea, etc.; Ligusticum chuanxiong has the effects of activating blood circulation and promoting qi circulation, and dispelling wind and relieving pain, and is used for qi stagnation and blood stasis, headache, rheumatic arthralgia, etc.; Aucklandia lappa has the effects of promoting qi circulation and relieving pain, and strengthening the spleen and promoting digestion, and is used for qi stagnation and abdominal pain, indigestion, etc.; Spatholobus suberectus has the effects of activating blood circulation and unblocking the meridians, and dispelling wind and dampness, and is used for rheumatic arthralgia, joint pain, etc.

[0058] The ointment improves spleen deficiency and qi stagnation through a triple pathway of "warming the middle jiao, promoting qi circulation, and activating blood circulation." Specifically, Lindera root, dried ginger, and Sichuan pepper warm and tonify spleen yang, dispel cold pathogens, target the root cause of spleen and stomach deficiency and cold, restore digestive function, and achieve the effect of warming the middle jiao and dispelling cold. Costus root, Sichuan lovage rhizome, and Lindera root relieve bloating and pain by clearing spleen and stomach qi stagnation, address the symptoms of qi stagnation, promote the ascending and descending of qi, and achieve the effect of promoting qi circulation and relieving pain. Sichuan lovage rhizome and chicken blood vine improve local qi and blood stasis, enhance drug penetration, and, in conjunction with qi-regulating herbs, promote qi and blood circulation, achieving the effect of activating blood circulation and clearing the meridians, while also improving drug absorption efficiency. Angelica root and processed Aconitum carmichaelii root dispel cold and dampness pathogens, relieve limb numbness and pain, assist in dispelling cold, and eliminate the influence of dampness on the spleen and stomach. In addition, as a topical ointment, Angelica root, Sichuan pepper, and Sichuan lovage rhizome contain volatile oils that can promote skin penetration and act on abdominal acupoints (such as Zhongwan and Shenque) or painful areas, directly warming the spleen and stomach.

[0059] In this application, the active ingredient refers to a component derived from traditional Chinese medicine (TCM), including but not limited to TCM raw materials, TCM extracts, effective parts of TCM, TCM monomeric components, and their derivatives, which possess biological activity and can directly or indirectly exert preventive, diagnostic, alleviating, therapeutic, or curative effects on diseases or health states. This component can be used alone or in combination with other pharmaceutically acceptable carriers, excipients, or auxiliary ingredients to form a pharmaceutical composition or formulation. TCM raw materials include plant-based drugs, animal-based drugs, mineral-based drugs, and their processed products (such as processed products). TCM extracts are extracts obtained from TCM raw materials through methods such as solvent extraction, distillation, supercritical extraction, and enzymatic hydrolysis, including crude extracts, refined extracts, and their concentrates. Effective parts of TCM are components with specific pharmacological activities obtained by further separation and purification from TCM extracts, such as total flavonoids, total saponins, total alkaloids, and polysaccharides. TCM monomeric components are single chemical components isolated from TCM, including but not limited to alkaloids, flavonoids, saponins, terpenes, phenolic acids, polysaccharides, and volatile oils. Derivatives: Derivatives obtained by chemically modifying or structurally altering monomeric components of traditional Chinese medicine, including but not limited to salts, esters, glycosides, prodrugs, etc.

[0060] In some embodiments, the active ingredients include the following components by weight: 0.1-10 parts of Lindera strychnifolia, 1-15 parts of Angelica dahurica, 1-15 parts of Zanthoxylum bungeanum, 0.01-5 parts of processed Aconitum carmichaelii, 0.1-10 parts of dried ginger, 0.1-10 parts of Ligusticum chuanxiong, 0.1-10 parts of Aucklandia lappa, and 0.1-10 parts of Spatholobus suberectus.

[0061] In some embodiments, the active ingredient comprises the following components by weight: Lindera root in any weight range of 0.1-10 parts, 0.5-9 parts, 1-8 parts, 1-7 parts, 1-6 parts, 1-5 parts, 1-4 parts, 1-3 parts, or 0.1-10 parts, specifically, for example, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or any weight range of 0.1-10 parts; and the contents of Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0062] In some embodiments, the active ingredients include the following components by weight: Angelica dahurica in any weight range of 1-15 parts, 2-14 parts, 2-13 parts, 2-12 parts, 2-10 parts, 2-8 parts, 2-6 parts, or 1-15 parts, specifically, for example, any weight range of 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, or 1-15 parts; and the contents of Lindera strychnifolia, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0063] In some embodiments, the active ingredients include the following components by weight: any weight range of 1-15 parts, 2-14 parts, 2-13 parts, 2-12 parts, 2-10 parts, 2-8 parts, 2-6 parts, or 1-15 parts of Sichuan pepper, specifically, for example, any weight range of 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, or 1-15 parts; and the contents of Lindera root, Angelica dahurica, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0064] In some embodiments, the active ingredients include the following components by weight: 0.01-5 parts, 0.1-4 parts, 0.5-3 parts, 0.5-2 parts, or any weight range of 0.01-5 parts of processed Aconitum carmichaelii, specifically, for example, any weight range of 0.01 parts, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, or any weight range of 0.01-5 parts; and the contents of Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, Zingiber officinale, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0065] In some embodiments, the active ingredient comprises, by weight, the following components: dried ginger in any weight range of 0.1-10 parts, 0.5-9 parts, 1-8 parts, 1-7 parts, 1-6 parts, 1-5 parts, 1-4 parts, 1-3 parts, or 0.1-10 parts, specifically, for example, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or any weight range of 0.1-10 parts; and the contents of Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0066] In some embodiments, the active ingredients include the following components by weight: 0.1-10 parts, 0.5-9 parts, 1-8 parts, 1-7 parts, 1-6 parts, 1-5 parts, 1-4 parts, 1-3 parts, or any weight range of 0.1-10 parts of Ligusticum chuanxiong, specifically, for example, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or any weight range of 0.1-10 parts; and the contents of Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Aucklandia lappa, and Spatholobus suberectus are as described above.

[0067] In some embodiments, the active ingredients include the following components by weight: 0.1-10 parts, 0.5-9 parts, 1-8 parts, 1-7 parts, 1-6 parts, 1-5 parts, 1-4 parts, 1-3 parts, or any weight range of 0.1-10 parts of Costus root, specifically, for example, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or any weight range of 0.1-10 parts; and the contents of Lindera root, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, and Spatholobus suberectus are as described above.

[0068] In some embodiments, the active ingredients include the following components by weight: 0.1-10 parts, 0.5-9 parts, 1-8 parts, 1-7 parts, 1-6 parts, 1-5 parts, 1-4 parts, 1-3 parts, or any weight range within the range of 0.1-10 parts, specifically, for example, 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or any weight range within the range of 0.1-10 parts; and the contents of Lindera root, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, and Aucklandia lappa are as described above.

[0069] In one specific embodiment, the active ingredients, by weight, comprise the following components: 2 parts Lindera root, 4 parts Angelica dahurica root, 4 parts Zanthoxylum bungeanum root, 1 part processed Aconitum carmichaelii root, 2 parts dried ginger, 2 parts Ligusticum chuanxiong rhizome, 2 parts Aucklandia lappa root, and 2 parts Spatholobus suberectus stem. In another specific embodiment, the active ingredients, by weight, comprise the following components: 0.1 parts Lindera root, 1 part Angelica dahurica root, 1 part Zanthoxylum bungeanum root, 0.01 parts processed Aconitum carmichaelii root, 0.1 parts dried ginger, 0.1 parts Ligusticum chuanxiong rhizome, 0.1 parts Aucklandia lappa root, and 0.1 parts Spatholobus suberectus stem. In yet another specific embodiment, the active ingredients, by weight, comprise the following components: 10 parts Lindera root, 15 parts Angelica dahurica root, 15 parts Zanthoxylum bungeanum root, 5 parts processed Aconitum carmichaelii root, 10 parts dried ginger, 10 parts Ligusticum chuanxiong rhizome, 10 parts Aucklandia lappa root, and 10 parts Spatholobus suberectus stem.

[0070] In this application, the matrix refers to the substance that constitutes the main body of the ointment and is used to carry, disperse, and stabilize the drug components. It is typically composed of one or more oils, waxes, polymers, or other suitable compounds, possessing suitable consistency, lubricity, and stability to ensure effective drug release and good skin contact. Generally, it has the following characteristics: forming a continuous phase to disperse or dissolve the drug components, maintaining the semi-solid physical form of the formulation; not directly contributing to the therapeutic effect of the main drug; having no chemical antagonism with the drug components; maintaining stable physicochemical properties during its shelf life; meeting the biocompatibility requirements of transdermal formulations; and not causing irritation.

[0071] In some embodiments, the matrix includes, but is not limited to, saturated hydrocarbons (such as petrolatum), liquid hydrocarbons (such as paraffin oil, mineral oil), synthetic hydrocarbons (such as hydrogenated polyisobutylene), synthetic esters (such as isopropyl myristate, ethylhexyl palmitate), natural esters (such as lanolin), or any combination of one or more thereof.

[0072] In some embodiments, the matrix is ​​petrolatum. In some embodiments, the matrix comprises petrolatum and paraffin oil. Petrolatum possesses excellent occlusive and moisturizing properties, forming a dense oil film on the skin surface, effectively reducing moisture evaporation and thus prolonging the drug's action time on the skin. Its high viscosity and low oxygen permeability significantly delay the release of active ingredients, protecting volatile components in the drug from oxidative degradation and ensuring the drug's stability and efficacy. Paraffin oil, by reducing the system's viscosity, significantly improves the spreadability of the ointment, making it easier to apply and distribute on the skin surface. Paraffin oil and petrolatum have good compatibility, forming a uniform homogeneous system and preventing the aggregation of active ingredients. Its low polarity highly matches the polarity of volatile oils, effectively enhancing the transdermal efficiency of lipid-soluble components. During transdermal delivery, the occlusive properties of petrolatum temporarily expand the intercellular spaces of the stratum corneum, forming a "channel" for drug penetration, while paraffin oil, as a lipid-soluble carrier, carries volatile oil components through the intercellular lipid pathway for efficient penetration. The combination of petrolatum's sustained-release properties and paraffin oil's penetration-enhancing effect achieves a biphasic drug delivery mode of "rapid initial penetration and sustained later release," ensuring that the drug concentration in the skin can be maintained at an effective level for a long time. Furthermore, the non-polar matrix of petrolatum and paraffin oil is highly compatible with the polarity of lipid-soluble traditional Chinese medicine components (such as volatile oils and alkaloids), avoiding phase separation or component inactivation, further guaranteeing drug stability and transdermal efficiency.

[0073] In some embodiments, the matrix is ​​petrolatum and paraffin oil. In some embodiments, the mass of the paraffin oil is 1 to 50 wt% of the sum of the masses of the active ingredient and petrolatum; for example, it can be any mass ratio within the range of 1 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt%, 25 wt%, 30 wt%, 35 wt%, 40 wt%, 45 wt%, 50 wt%, or 1 to 50 wt%. In a preferred embodiment, the mass of the paraffin oil is 10 wt% of the sum of the masses of the active ingredient and petrolatum. Within this ratio range, petrolatum can effectively perform its functions of sealing and moisturizing, and delaying the release of the active ingredient, while paraffin oil can effectively reduce the viscosity of the system, improve the spreadability of the ointment, and enhance the transdermal efficiency of fat-soluble components. When the ratio is within this range, the two can work synergistically to maintain the stability of the ointment system and the effective delivery of the drug.

[0074] In some embodiments, the mass ratio of the active ingredient to the matrix is ​​any mass ratio within the range of 1:(1-10), 1:(1-8), 1:(1-6), 1:(1-4), 1:(1-2), or 1:(1-10); for example, it can be any mass ratio within the range of 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, or 1:(1-10). In a preferred embodiment, the mass ratio of the active ingredient to the matrix is ​​1:1.

[0075] In another embodiment, a method for preparing a paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation is provided, comprising: pulverizing the active ingredients separately and mixing them according to the prescription ratio to obtain a mixed fine powder; heating the matrix until completely melted, mixing the mixed fine powder with the molten matrix and homogenizing; and cooling to obtain a paste-like dressing.

[0076] In this application, pulverization refers to the process of reducing the particle size of solid materials (such as traditional Chinese medicine materials, chemical raw materials, etc.) from a larger particle size to a smaller particle size through mechanical, physical, or chemical forces, thereby changing the particle size, surface area, or physical properties of the material to meet the requirements of formulation preparation, drug release, or other processes. The pulverization process can include, but is not limited to, the following methods: mechanical pulverization, physical pulverization, and chemical pulverization. Mechanical pulverization breaks materials through the shearing, impact, extrusion, grinding, and other forces of mechanical equipment, including but not limited to ball mills, hammer mills, air jet mills, vibratory mills, and roller mills. Physical pulverization changes the physical state or structure of materials through physical methods (such as cryogenic pulverization and ultrasonic pulverization), making them easier to break. Chemical pulverization changes the chemical properties or structure of materials through chemical treatment (such as solvent treatment and acid-base treatment), making them easier to break or disperse. Any suitable equipment can be used in the pulverization process, including but not limited to ball mills, hammer mills, air jet mills, vibratory mills, colloid mills, ultrafine pulverizers, and cryogenic pulverizers. The pulverization process can be carried out at room temperature, low temperature, or high temperature, with specific conditions determined according to the properties of the material and process requirements. The crushed material can undergo subsequent processing such as sieving, grading, and drying to ensure uniform particle size distribution and material stability.

[0077] In some embodiments, the active ingredients are pulverized to a particle size of 100-300 mesh. Preferably, the active ingredients are pulverized to a particle size of 200 mesh. This particle size range is particularly suitable for the preparation of ointment dressings, enabling the drug components to be uniformly dispersed in the matrix, improving the stability of the formulation and drug release performance. It is understood that 100-300 mesh refers to the number of openings in a standard sieve that the material can pass through. Specifically, 100 mesh means the material can pass through a sieve with 100 openings per inch, while 300 mesh means the material can pass through a sieve with 300 openings per inch. Therefore, 100-300 mesh encompasses material particles that can pass through sieves between 100 and 300 mesh. Specifically, the particle size of the pulverized active ingredients can be, for example, 100 mesh, 150 mesh, 200 mesh, 250 mesh, or 300 mesh.

[0078] In this application, heating the matrix to complete melting refers to the process of transforming the selected matrix material from a solid to a liquid state, i.e., a completely molten state, through heating during the preparation process. The purpose of this step is to ensure that the matrix can fully dissolve or mix with other components (such as active ingredients, additives, etc.), thereby forming a homogeneous and stable formulation. Heating can be performed using a water bath, oil bath, electric heating mantle, microwave heating, or other suitable heating equipment. During heating, uniform stirring should be maintained to avoid localized overheating or matrix decomposition. A completely molten matrix should exhibit a homogeneous liquid state, free of solid particles or unmelted lumps. The melting state can be determined through visual observation, temperature measurement, and / or flowability testing. Visual observation: When the matrix transforms from a solid to a liquid state, its appearance will change significantly, such as becoming lighter in color or increasing transparency. Visual observation can provide a preliminary assessment of whether the matrix is ​​completely molten. Temperature measurement: The temperature of the matrix is ​​measured using a thermometer. When the temperature reaches or slightly exceeds the melting point of the matrix, it can be considered that the matrix is ​​completely molten. However, it should be noted that the melting points of different matrices may vary and are affected by the heating method and environmental conditions. Flowability test: Drop a small amount of molten matrix onto a flat surface and observe its flowability and diffusion. If the matrix can flow freely and diffuse evenly, it can be considered to be completely melted.

[0079] In some embodiments, the substrate is heated to a temperature of 60–90°C. This temperature range ensures that most commonly used substrates (such as petrolatum, paraffin oil, beeswax, etc.) are completely melted, while avoiding overheating that could lead to degradation of the substrate or pharmaceutical ingredients. This temperature range is suitable for the preparation of most ointment dressings, effectively preventing the substrate or heat-sensitive pharmaceutical ingredients from decomposing or becoming ineffective due to high temperatures while maintaining the substrate's fluidity and uniformity. Specifically, the substrate can be heated to a temperature of 60°C, 61°C, 62°C, 63°C, 64°C, 65°C, 66°C, 67°C, 68°C, 69°C, 70°C, 72°C, 74°C, 75°C, 78°C, 80°C, 82°C, 84°C, 86°C, 88°C, 90°C, or any temperature within the range of 60–90°C.

[0080] In this application, homogenization refers to the process of thoroughly mixing two or more materials (such as active ingredients and a matrix) using mechanical force, physical force, or other suitable methods to achieve a uniform distribution. Homogenization methods can include mechanical stirring, high-shear homogenization, ultrasonic homogenization, and air-jet mixing. Mechanical stirring uses equipment such as stirrers or impellers at appropriate speeds to uniformly mix the fine powder with the molten matrix. Any suitable equipment can be used, including but not limited to stirrers, high-shear homogenizers, colloid mills, ultrasonic homogenizers, and air-jet mixers. The endpoint of homogenization is considered reached when the mixture exhibits a uniform color, texture, and flowability, with no visible particles or agglomerates. The uniformity of the fine powder distribution can also be tested by sampling to ensure that the homogenization effect meets the requirements.

[0081] In some embodiments, the mixing and homogenization temperature is 50–80°C. This temperature range ensures that the matrix (such as petrolatum, paraffin oil, etc.) remains in a molten state while providing suitable conditions for the uniform dispersion of the fine powder. The matrix can be heated to 50–80°C using a temperature control device (such as a water bath, oil bath, or heating mantle) and the temperature maintained constant during the mixing and homogenization process. Using mechanical stirring or a high-shear homogenizer, the fine powder is slowly added to the molten matrix at 50–80°C while stirring continuously to ensure uniform dispersion. Specifically, the mixing and homogenization temperature can be 50°C, 51°C, 52°C, 53°C, 54°C, 55°C, 57°C, 60°C, 63°C, 65°C, 67°C, 69°C, 71°C, 74°C, 76°C, 79°C, 80°C, or any temperature within the range of 50–80°C.

[0082] In some embodiments, the mixed fine powder is added to the molten matrix in two or more batches. Adding the mixed fine powder in batches can more effectively avoid localized excessive concentrations or agglomeration. Adding a small amount of fine powder each time allows for more uniform dispersion in the molten matrix, thereby improving overall mixing uniformity. The mixed fine powder is divided into two or more equal portions and slowly added to the molten matrix in two or more batches. After each addition, the mixture is thoroughly stirred or homogenized to ensure uniform dispersion in the matrix before the next addition. Alternatively, the mixed fine powder can be added in two or more unequal portions according to a certain gradient. For example, a smaller proportion of fine powder is added first, thoroughly stirred or homogenized to ensure sufficient dispersion in the matrix, establishing a preliminary dispersion system; then a larger proportion of fine powder is added, and stirring or homogenization is continued, and so on, until all the fine powder has been added, followed by a final overall homogenization process. In some embodiments, the mixed fine powder is added to the molten matrix in two, three, four, or more batches.

[0083] In this application, cooling refers to the process of transforming homogenized materials (including active ingredients and molten matrix) from a liquid or semi-liquid state into a solid or semi-solid state through temperature reduction, thereby forming a paste-like dressing with specific physical properties and drug release properties. Cooling methods can include natural cooling, where the homogenized materials are placed in a room temperature environment to allow them to cool naturally to a solid or semi-solid state. Alternatively, the cooling process can be accelerated using cooling equipment (such as water-cooled circulation systems, cold air equipment, cooling jackets, etc.) to shorten cooling time and improve production efficiency. The cooling endpoint of the paste can be determined through tactile testing, visual inspection, or instrumental testing (such as viscometers and rheometers).

[0084] In some embodiments, continuous stirring is maintained during the cooling process. Continuous stirring enables the material to dissipate heat evenly during cooling, avoiding uneven matrix crystallization or uneven distribution of drug components caused by excessively low or high local temperatures. It also prevents stratification or clumping caused by density differences or viscosity changes during cooling, ensuring the uniformity and stability of the ointment.

[0085] In some embodiments, the stirring rate during the cooling process is 100 to 140 rpm or any stirring rate within that range. For example, the stirring rate can be 100 rpm, 105 rpm, 110 rpm, 115 rpm, 120 rpm, 125 rpm, 130 rpm, 135 rpm, 140 rpm or any stirring rate within the range of 100 to 140 rpm.

[0086] In some embodiments, the cooling process includes a first cooling stage and a second cooling stage, wherein the cooling rate of the first cooling stage is greater than that of the second cooling stage. The first cooling stage rapidly reduces the temperature of the paste to minimize adverse reactions that may occur at high temperatures, such as degradation of the herbal ingredients or oxidation of the matrix. Building upon the rapid cooling in the first stage, the temperature of the paste is further reduced slowly to promote the stability and uniform curing of its internal structure. The slower cooling rate in this stage helps to avoid internal stress or cracks caused by rapid cooling. The second cooling stage, building upon the rapid cooling in the first stage, further slowly reduces the temperature of the paste to promote the stability and uniform curing of its internal structure.

[0087] To control the cooling rate, the first cooling stage can increase the flow rate and temperature of the cooling medium, such as by increasing the pump speed or opening more cooling channels, to accelerate heat transfer. Simultaneously, the stirring rate can be appropriately increased to promote heat transfer and uniform cooling within the paste. However, care must be taken to avoid excessive shearing that could damage the paste structure. The second cooling stage can reduce the flow rate of the cooling medium, such as by decreasing the pump speed or closing some cooling channels, to slow down heat transfer; the temperature of the cooling medium can be increased to approach room temperature, reducing the temperature gradient and extending the cooling time. Simultaneously, the stirring rate can be appropriately reduced to avoid unnecessary disturbance to the paste structure. However, a certain stirring intensity must still be maintained to ensure uniform distribution of the components within the paste.

[0088] In some embodiments, the cooling rate of the first cooling stage is 0.8 to 1.5 °C / min; specifically, it is 0.8 °C / min, 0.9 °C / min, 1 °C / min, 1.1 °C / min, 1.2 °C / min, 1.3 °C / min, 1.4 °C / min, 1.5 °C / min or any rate within the range of 0.8 to 1.5 °C / min.

[0089] In some embodiments, the cooling rate of the second cooling stage is 0.2 to 0.7 °C / min; specifically, it is 0.2 °C / min, 0.3 °C / min, 0.4 °C / min, 0.5 °C / min, 0.6 °C / min, 0.7 °C / min or any rate within the range of 0.2 to 0.7 °C / min.

[0090] In some implementations, the temperature range of the first cooling stage is 45–55°C. For example, it can be 45°C, 50°C, 55°C, or any temperature within the above range.

[0091] In some implementations, the temperature range of the second cooling stage is 25–45°C. For example, it can be 25°C, 30°C, 35°C, 40°C, 45°C, or any temperature within the above range.

[0092] This application also provides the use of the above-mentioned ointment dressing in the preparation of percutaneous therapeutic medical devices.

[0093] In this application, percutaneous therapeutic medical devices refer to medical devices that use ointment-like dressings as the main or auxiliary drug ingredients, prepared through a special process and applied to the surface of human skin. These medical devices utilize the active ingredients in traditional Chinese medicine ointments to directly deliver drugs to the lesion site or the systemic circulatory system through skin penetration, in order to achieve therapeutic, conditioning, or health-preserving purposes. Ointment-like dressings may include, but are not limited to, traditional Chinese medicine extracts, herbal powders, essential oils, etc., and their preparation forms can be diverse, such as patches, poultices, gel patches, ointment patches, etc.

[0094] In some embodiments, the percutaneous therapeutic medical device includes a carrier and a paste-like dressing loaded on the carrier. It is understood that the carrier refers to a material or structure for applying, loading, or supporting the paste-like dressing, which can closely adhere to the surface of human skin to ensure effective application, fixation, and penetration of the paste-like dressing. As a key component of the drug delivery system, the carrier safely and stably delivers the paste-like dressing to the skin, enabling the release and absorption of drug components within the body through skin penetration mechanisms.

[0095] The carrier includes, but is not limited to: patch-type carriers, such as polyester film and non-woven fabric; physical penetration enhancers, such as polylactic acid microneedles; and iontophoresis electrodes, such as silver / silver chloride electrodes. Specifically, the carrier is selected from one of the following: medical non-woven fabric, polymer film, silicone substrate, polymer foil, or pressure-sensitive adhesive patch.

[0096] In some embodiments, the surface of the carrier layer is physically or chemically treated to enhance the adhesion of the ointment dressing. Physical treatments include, but are not limited to: plasma treatment, bombarding the carrier surface with plasma (such as argon or oxygen) to increase surface roughness and active groups; laser treatment, using a laser beam to etch micro / nano structures (such as micropores or trenches) onto the carrier surface; and mechanical polishing, increasing the surface roughness of the carrier through mechanical means such as sandpaper or sandblasting. Chemical treatments include, but are not limited to: surface grafting modification, grafting functional groups (such as carboxyl or amino groups) or polymers (such as polyethylene glycol) onto the carrier surface; coating treatment, applying a functional coating (such as a silane coupling agent or polydopamine) to the carrier surface; and chemical etching, etching the carrier surface using acids, alkalis, or oxidizing agents to form micro / nano structures.

[0097] This application also provides a percutaneous therapeutic medical device, comprising a carrier and the aforementioned ointment dressing loaded on the carrier. The carrier is selected from one of the following: medical nonwoven fabric, polymer film, silicone substrate, metal foil, polymer foil, or pressure-sensitive adhesive patch. The surface of the carrier layer may be physically or chemically treated to enhance the adhesion of the ointment dressing. The ointment dressing comprises an active ingredient and a matrix, wherein the active ingredient comprises the following components: Lindera strychnifolia, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0098] This application also provides a nursing kit, including the above-mentioned ointment dressing and a matching ironing and rubbing stone. The ointment dressing comprises active ingredients and a matrix, wherein the active ingredients include the following components: Lindera root, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

[0099] Bian stone contains various trace elements and can generate abundant ultrasonic pulses. It utilizes unique biophysical effects such as induced heating, a very broad far-infrared radiation spectrum, and the generation of dense ultrasonic pulses during friction. Contact with the skin can accelerate blood circulation. During treatment, it can also continuously stimulate abdominal acupoints, unblock meridians, and regulate qi and blood. The Bian stone ironing and massage method for penetrating traditional Chinese medicine is based on the theories of viscera and meridians in traditional Chinese medicine. By applying heat to the skin at acupoints, it produces a certain stimulating effect, which has the functions of warming and assisting yang qi, unblocking meridians, and regulating water metabolism.

[0100] In some implementations, the combined use of the Bian stone and the ointment dressing includes: first applying the ointment dressing to the skin surface, and then using the Bian stone for directional ironing; or pre-applying the ointment dressing to the surface of the Bian stone and achieving simultaneous drug delivery and physiotherapy through heating and / or pressure.

[0101] Specifically, preheat the Bian stone, instruct the patient to lie flat, expose the treatment area, and use a tissue to shield clothing from stains. Apply the herbal ointment evenly to the preheated Bian stone ball, spreading it around the navel, from the Shangwan acupoint to the Qihai acupoint, and then to the Tianshu acupoint on both sides. Massage the Shenque, Zhongwan, Jianli, Tianshu, Guanyuan, and Qihai acupoints clockwise, applying pressure to each point while monitoring the patient's sensations. Preheat the Bian stone to 60℃, maintaining a temperature of 55-65℃ during treatment, ensuring the patient feels a comfortable warmth. After 15 minutes of massage, apply a heat-insulating film to the treatment area to prevent staining clothing and allow the herbal ointment to continue penetrating the skin. After 20 minutes, remove the film, wipe the ointment clean with a tissue, and inquire about the patient's sensations and improvement in abdominal distension.

[0102] Operating Techniques (Two-Side Four-Method): ① Warming Method: Start with a low temperature and gradually increase the temperature to warm and soothe the Shenque acupoint, stimulating Qi and blood circulation. ② Pushing Method (used between acupoints): Use a Bian stone to massage from Shenque to the right Tianshu acupoint, then to Zhongwan acupoint, then to the left Tianshu acupoint, and back to Shenque. ③ Pressing Method (used on the acupoints themselves): Press vertically downwards on Shenque, Zhongwan, Tianshu, etc. ④ Rubbing Method (used on the acupoints themselves): Use a Bian stone to massage the abdomen in a clockwise direction, expanding the massage area.

[0103] The ironing stone synergistically enhances the effect of the ointment dressing in the following ways:

[0104] The far-infrared radiation of Bian stone expands skin pores, accelerating drug absorption;

[0105] The thermal conductivity of Bian stone helps maintain the thermal stability of the active ingredients in traditional Chinese medicine ointments.

[0106] The mechanical pressure from Bian stone massage promotes local blood circulation.

[0107] In some embodiments, the mineral composition of the ironing stone includes silicon dioxide (SiO2), calcium oxide (CaO), and trace elements iron (Fe) and zinc (Zn). Specifically, the material of the ironing stone is selected from Sishui Bian stone, Xiuyan jade, or basalt.

[0108] In some embodiments, the surface of the Bianstone is treated with a nano-coating to enhance its affinity with the ointment dressing. The nano-coating material can be inorganic nanomaterials, such as silicon dioxide (SiO2), titanium dioxide (TiO2), zinc oxide (ZnO), etc.; or organic nanomaterials, such as polydopamine (PDA), polyethylene glycol (PEG), chitosan, etc.; or composite nanomaterials, such as SiO2-PEG composite coatings, TiO2-chitosan composite coatings. The nano-coating can be prepared by depositing it onto the Bianstone surface using various processes such as physical vapor deposition, chemical vapor deposition, and sol-gel methods.

[0109] In some embodiments, the ironing Bian stone integrates a heating element. Embedding the heating element within the Bian stone allows heat to be evenly transferred to its surface via a heat-conducting material (such as aluminum alloy). By raising the surface temperature of the Bian stone, the heating element expands skin pores, promoting transdermal absorption of the herbal ointment. Simultaneously, the warming effect enhances local blood circulation, relieves muscle pain and inflammation, and works synergistically with the herbal ointment.

[0110] In some implementations, the heating element regulates the surface temperature of the Bianstone to 60–90°C via resistance heating. Specifically, the heating element includes, but is not limited to: resistance wire heating elements, such as nickel-chromium alloy (NiCr) or iron-chromium-aluminum alloy (FeCrAl); PTC (positive temperature coefficient) heating elements, such as barium titanate-based ceramics, whose resistance increases with temperature, automatically limiting current to prevent overheating, eliminating the need for additional temperature control circuitry and avoiding the risk of burns; carbon fiber heating films, which have a short thermal response time, reaching the set temperature within seconds; and semiconductor heating elements, such as bismuth telluride (Bi2Te3)-based semiconductors, which can both heat and cool, suitable for temperature difference control.

[0111] The specific implementation of the present invention will be described in detail below with reference to examples and specific circumstances.

[0112] Example 1

[0113] A paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation is made from active ingredients and a matrix. The active ingredients consist of the following components: 2g of Lindera strychnifolia, 4g of Angelica dahurica, 4g of Zanthoxylum bungeanum, 1g of processed Aconitum carmichaelii, 2g of dried ginger, 2g of Ligusticum chuanxiong, 2g of Aucklandia lappa, and 2g of Spatholobus suberectus. The matrix consists of 15.2g of petrolatum and 3.8g of paraffin oil.

[0114] Lindera root, Angelica dahurica, Sichuan pepper, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are dried at low temperature (45-50℃) until the moisture content is ≤8%. They are then ultra-finely pulverized to a 300-mesh fine powder, sieved, and mixed evenly according to the prescription ratio to obtain a mixed fine powder. Vaseline is melted in a water bath at 70±5℃, paraffin oil is added, and the mixture is stirred evenly to form a homogeneous matrix mixture. The molten matrix mixture is cooled to 55℃, and the entire mixed fine powder is added in three batches, with a 3-minute interval between each addition. After each addition, the mixture is stirred at 300 rpm to ensure uniform dispersion. After completion, the mixture is continuously stirred at a cooling rate of 1℃ / min and a stirring rate of 120 rpm until the temperature drops to 45℃. Then, the mixture is cooled at a cooling rate of 0.5℃ / min and a stirring rate of 120 rpm until it reaches near room temperature (25-30℃) and the ointment is completely solidified. The ointment is then placed in a clean container and sealed for storage.

[0115] Example 2

[0116] A paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation is made from active ingredients and a matrix. The active ingredients consist of the following components: 0.1g of Lindera strychnifolia, 1g of Angelica dahurica, 1g of Zanthoxylum bungeanum, 0.01g of processed Aconitum carmichaelii, 0.1g of dried ginger, 0.1g of Ligusticum chuanxiong, 0.1g of Aucklandia lappa, and 0.1g of Spatholobus suberectus. The matrix consists of 22.3g of petrolatum and 2.8g of paraffin oil.

[0117] Lindera root, Angelica dahurica, Sichuan pepper, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are dried at low temperature (45-50℃) until the moisture content is ≤8%. They are then ultra-finely pulverized to a 100-mesh fine powder, sieved, and mixed evenly according to the prescription ratio to obtain a mixed fine powder. Vaseline is melted in a water bath at 65±5℃, paraffin oil is added, and the mixture is stirred evenly to form a homogeneous matrix mixture. The molten matrix mixture is cooled to 50℃, and the entire mixed fine powder is added in two batches, with a 3-minute interval between each addition. After each addition, the mixture is stirred at 300 rpm to ensure uniform dispersion. After completion, the mixture is continuously stirred at a cooling rate of 1℃ / min and a stirring rate of 100 rpm until the temperature drops to 45℃. Then, the mixture is cooled at a cooling rate of 0.5℃ / min and a stirring rate of 100 rpm until it reaches near room temperature (25-30℃) and the ointment is completely solidified. The ointment is then placed in a clean container and sealed for storage.

[0118] Example 3

[0119] A paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation is made from active ingredients and a matrix. The active ingredients consist of the following components: 10g of Lindera strychnifolia, 15g of Angelica dahurica, 15g of Zanthoxylum bungeanum, 5g of processed Aconitum carmichaelii, 10g of dried ginger, 10g of Ligusticum chuanxiong, 10g of Aucklandia lappa, and 10g of Spatholobus suberectus. The matrix consists of 170g of petrolatum and 255g of paraffin oil.

[0120] Lindera root, Angelica dahurica, Sichuan pepper, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are dried at low temperature (45-50℃) until the moisture content is ≤8%. They are then ultra-finely pulverized to a 200-mesh fine powder, sieved, and mixed evenly according to the prescription ratio to obtain a mixed fine powder. Vaseline is melted in a water bath at 70±5℃, paraffin oil is added, and the mixture is stirred evenly to form a homogeneous matrix mixture. The molten matrix mixture is cooled to 55℃, and the entire mixed fine powder is added in three batches, with a 3-minute interval between each addition. After each addition, the mixture is stirred at 300 rpm to ensure uniform dispersion. After completion, the mixture is continuously stirred at a cooling rate of 1℃ / min and a stirring rate of 140 rpm until the temperature drops to 45℃. Then, the mixture is further stirred at a cooling rate of 0.5℃ / min and a stirring rate of 140 rpm until it reaches near room temperature (25-30℃) and the ointment is completely solidified. The ointment is then placed in a clean container and sealed for storage.

[0121] Comparative Example 1

[0122] A paste-like dressing for invigorating the spleen, replenishing qi, and relieving stagnation is made from active ingredients and a matrix. The active ingredients consist of the following components: 2g of Lindera strychnifolia, 4g of Angelica dahurica, 4g of Zanthoxylum bungeanum, 1g of processed Aconitum carmichaelii, 2g of dried ginger, 2g of Ligusticum chuanxiong, 2g of Aucklandia lappa, and 2g of Spatholobus suberectus. The matrix consists of 47.5g of petrolatum and 47.5g of paraffin oil.

[0123] Lindera root, Angelica dahurica, Sichuan pepper, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus are dried at low temperature (45-50℃) until the moisture content is ≤8%, then ultra-finely pulverized to 200 mesh. After sieving, they are mixed evenly according to the prescription ratio to obtain a mixed fine powder. The above mixed fine powder is decocted in boiling water (solid-liquid ratio of 1:10) for 10 minutes to obtain the decoction, which is the water decoction for transdermal patches.

[0124] Experimental Example

[0125] 1. Experimental Methods

[0126] Healthy male nude mice were randomly divided into two groups (n=3): the transdermal patch drug powder test sample group (product of Example 1) and the transdermal patch decoction test sample group (product of Comparative Example 1). After euthanizing the mice by cervical dislocation, the abdominal skin was peeled off, subcutaneous fat tissue and adhesions were removed, the mice were repeatedly rinsed with physiological saline, the surface moisture was absorbed with filter paper, and the skin was wrapped in aluminum foil and sealed for storage at -80℃ for later use. In the percutaneous penetration test, the treated skin was fixed in a diffusion pool (effective penetration area 3.14 cm²). 2 The receiving chamber (with a volume of 18.5 mL) was prepared with the dermis facing upwards and the stratum corneum upwards. The receiving chamber was filled with physiological saline containing 20% ​​ethanol (after degassing), and maintained at (37±0.5)℃ in a constant temperature water bath with a magnetic stirring speed of 350 r / min. Different prepared transdermal samples were evenly applied to the surface of the stratum corneum. Receiving fluid was collected at 0.5, 1, and 3 hours (an equal volume of receiving fluid was replenished after each sampling). The collected samples were sealed and stored at 4℃ for later analysis.

[0127] Take 0.2 g of the medicinal ointment, add 3 times the amount of methanol, sonicate for 10 minutes, centrifuge at 12000g for 10 minutes at 4℃, collect the supernatant, dilute 3 times, and inject. Take 0.2 mL of the medicinal decoction, add 3 times the amount of methanol, sonicate for 10 minutes, centrifuge at 12000g for 10 minutes at 4℃, collect the supernatant, dilute 3 times, and inject. The component composition of the ointment and decoction was tested using this method, and the results are shown in Table 1.

[0128] Two mL of transdermal absorption liquid from both the ointment and decoction was collected at time points of 0.5, 1, and 3 hours, evaporated to dryness under reduced pressure at 30°C, reconstituted with 200 μL of methanol, centrifuged at 12000 g for 10 min at 4°C, and the supernatant was collected for injection. The transdermal absorption of different components was tested using this method, and the results are shown in Table 2.

[0129] 2. Instruments and Reagents

[0130] Waters Acquity UPLC ultra-high performance liquid chromatography system - Synapt G2-Si HDMS high-resolution ion mobility mass spectrometry platform (Waters Corporation, USA), Acquity UPLC BEH C18 column (2.1mm × 100mm, 1.7μm Wasters, USA), Sigma 3-18K centrifuge (Sigma, USA);

[0131] Methanol (chromatographic grade), acetonitrile (chromatographic grade), and formic acid (chromatographic grade) were all purchased from Fisher.

[0132] 3. LC-MS / MS detection method

[0133] 3.1 Chromatographic conditions

[0134] Acquity UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm, Waters Corporation, USA); mobile phase: 0.1% formic acid water (A) to 0.1% formic acid acetonitrile (B); flow rate: 0.3 ml / min; injection volume: 5.0 μl; column temperature: 40 °C; sample chamber temperature: 4 °C; gradient elution conditions: 0–1.0 min 95.0% A; 1.0–12.0 min 95%–0% A; 12.0–15.0 min 0% A; 15.0–15.1 min 0%–95% A; 15.1–16.0 min 95% A.

[0135] 3.2 Mass Spectrometry Conditions

[0136] Electrospray ionization (ESI) was used, with a data acquisition range of m / z 50–1200. The volumetric flow rate was 800 L / h in both positive and negative modes. The desolvation gas temperature was 450℃ in positive mode and 400℃ in negative mode. The ion source temperature was 110℃ in both positive and negative modes. The capillary voltage was 3.5 kV in positive mode and 2.2 kV in negative mode. The collision voltage was 30–60 V. Sodium formate was used to correct the mass axis. MassLynx V4.1 was used for data acquisition. The Unify database V3.6.0.21 was used for identification of traditional Chinese medicine components. Progenesis QI software V3.0.3.0 was used to extract drug component peaks from transdermal samples, and peak area was used to screen transdermal precursor drug components.

[0137] 4. Data Analysis: Statistical methods (such as t-test, correlation analysis), significance threshold (p-value).

[0138] Experiment Example 1: Component Identification and Transdermal Test

[0139] The dressings from Example 1 and Comparative Example 1 were divided into 3 groups, with 0.2g of each sample added. Methanol was added, and the mixture was extracted by sonication for 10 minutes. The mixture was then centrifuged at 12000r / min for 10 minutes at 4℃. The supernatant was collected, diluted 3 times, and injected for mass spectrometry analysis. The average of the 3 groups was taken. The results are shown in Table 1. The transdermal results of the dressings from Example 1 and Comparative Example 1 were also recorded, and the results are shown in Table 2.

[0140] like Figure 1 , Figure 2 As shown in Table 1, this application identified a total of 92 chemical components, covering nine medicinal materials: Ligusticum chuanxiong, Angelica dahurica, Aconitum carmichaelii, Zanthoxylum bungeanum, Lindera strychnifolia, Spatholobus suberectus, Angelica sinensis, Aucklandia lappa, and Zingiber officinale. Specific component analysis of these medicinal materials showed that Ligusticum chuanxiong (16 components), Angelica dahurica (20 components), Zingiber officinale (21 components), Lindera strychnifolia (14 components), Spatholobus suberectus (5 components), Aconitum carmichaelii (2 components), Zanthoxylum bungeanum (13 components), and Aucklandia lappa (13 components) all contained characteristic components. Among these, 70 components were unique to a single medicinal material, and 12 were shared by two or more medicinal materials (e.g., chlorogenic acid and cryptochlorogenic acid are shared by Ligusticum chuanxiong and Spatholobus suberectus).

[0141] Seventy-seven components were detected in both the ointment and decoction. The ointment was dominated by fat-soluble components, with terpenes (21%), alkaloids (15%), and coumarins (18%) being particularly prominent, especially gingerone series from dried ginger, alkaloids from Sichuan pepper, and lactones unique to Lindera root. The decoction, on the other hand, was richer in water-soluble components, with glycosides (22%), organic acids (20%), and phenols (12%) being the dominant components, primarily phenolic acids from Ligusticum chuanxiong, coumarin glycosides from Angelica dahurica, and costus root terpene lactones. Both formulations retained chlorogenic acid components common to Ligusticum chuanxiong and Spatholobus suberectus, and key coumarin components such as isoimperatorin and imperatorin from Angelica dahurica remained stable in both formulations, suggesting they may be the core active substances in the transdermal drug delivery system.

[0142] The transdermal test results are shown in Table 2, with a total of 47 transdermal absorption components identified. Comparative analysis showed a significant divergence in the transdermal component profiles of the decoction and the ointment. The two dosage forms shared 36 common components (75% of the total), covering core active substances such as chlorogenic acid (Ligusticum chuanxiong, Spatholobus suberectus), butylphthalide (Angelica sinensis, Ligusticum chuanxiong), and imperatorin (Angelica dahurica), indicating their basic transdermal delivery capabilities for alkaloids, coumarins, and lactones. The ointment specifically detected two unique components: methyl palmitate (dried ginger, Angelica dahurica, Ligusticum chuanxiong) and pentadecylaldehyde (Angelica dahurica). Notably, the decoction contained 9 unique components (19.1%), among which reticuloicin, iso-linderoline, and dehydro-linderoline from Lindera strychnifolia, as well as the active component of Ligusticum chuanxiong, ligustilide Q, exhibited significant transdermal selectivity. The results confirm that dosage form selection can specifically regulate the transdermal behavior of certain ingredients, providing experimental basis for the precise design of topical Chinese medicine preparations.

[0143] Table 1. Mass spectrometry identification results of components contained in decoctions and ointments.

[0144]

[0145]

[0146]

[0147]

[0148]

[0149]

[0150]

[0151]

[0152] Table 2. Transdermal properties of different components in ointments and decoctions

[0153]

[0154]

[0155] Note: In Table 2, "×" indicates that the component was not detected transdermally; "3,√" indicates that the component was detected transdermally in the transdermal absorption solution after 3 hours; "1,√" indicates that the component was detected transdermally in the transdermal absorption solution after 1 hour; and "0.5,√" indicates that the component was detected transdermally in the transdermal absorption solution after 0.5 hours (i.e., 30 minutes).

[0156] The ointment dressing of this application is formulated according to the principles of monarch, minister, assistant, and guide, with strict compatibility and synergistic effects. It is scientifically prepared, has stable quality, good efficacy, and has achieved very good beneficial technical results through clinical trials. The relevant experimental data are as follows (taking Example 1 as an example).

[0157] Experimental Example 2: Clinical Trial of Bianstone Ironing Paste

[0158] I. Case Selection

[0159] Ninety-five patients with chronic gastritis admitted to the Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences from June 2023 to May 2025 were selected as the study subjects. There were 45 males and 50 females, aged 27 to 76 years; 24 cases were diagnosed with liver-stomach qi stagnation syndrome and 71 cases were diagnosed with spleen-stomach deficiency-cold syndrome.

[0160] II. Treatment Plan

[0161] 2.1 Preparation of materials: ① Electrified Bianstone Tai Chi Ball (produced by Beijing Jinlong Kangerfu Traditional Chinese Medicine Scraping and Cupping Research Institute); ② Spleen-strengthening Chinese herbal ointment: Example 1; ③ Insulation film: Ordinary food preservation film, 30cm wide; ④ Timer: Used for timing during operation; ⑤ Paper towels: Ordinary hand towels to avoid soiling the patient's clothes.

[0162] 2.2 Operation Method: Preheat the Bianstone Tai Chi ball by charging it. Instruct the patient to lie flat, exposing the treatment area. Use a tissue to shield clothing from stains. Apply the herbal ointment evenly to the preheated Bianstone Tai Chi ball, spreading it evenly around the navel, from the Shangwan acupoint to the Qihai acupoint, and laterally to the Tianshu acupoint. Massage the Shenque, Zhongwan, Jianli, Tianshu, Guanyuan, and Qihai acupoints clockwise, applying pressure to each point while monitoring the patient's sensations. Preheat the Bianstone Tai Chi ball to 45℃, maintaining a temperature of 45-65℃ during operation, ensuring the patient feels a comfortable warmth. After 15 minutes of massage, apply a heat-insulating film to the treatment area to prevent staining clothing, allowing the herbal ointment to continue penetrating the skin. After 20 minutes, remove the film, wipe the ointment clean with a tissue, and inquire about the patient's sensations and improvement in abdominal distension. One course of treatment lasts 7 days.

[0163] 2.3 Precautions for Operation: The Bianstone Tai Chi Ball needs to be preheated before use. The preheating temperature should not exceed 45℃ to avoid sudden hot or cold stimulation that may cause discomfort to the patient. During the operation, the patient's reaction should be closely observed, and the massage intensity and heat should be adjusted in a timely manner to prevent skin damage. Massage is prohibited during menstruation; massage is prohibited for patients who are excessively hungry or full; massage is prohibited for patients with skin infections, scars, or bleeding tendencies. If skin redness, itching, or other symptoms occur after using the ointment, massage should be stopped immediately and a doctor should be notified.

[0164] 2.4 Observation Indicators: The relief of abdominal distension was evaluated according to the relevant standards in the "Traditional Chinese Medicine Diagnosis and Treatment Plan for 95 Diseases in 22 Specialties". Symptoms such as upper abdominal pain, upper abdominal burning sensation, and postprandial fullness were scored according to severity. The percentage of symptom improvement was calculated as: [(Total symptom score before treatment - Total symptom score after treatment)] / Total symptom score before treatment × 100%. Cure: Symptoms completely disappeared; Significant effect: Symptom improvement percentage ≥ 80%; Improvement: 50% ≤ Symptom improvement percentage < 80%; Ineffective: Symptom improvement percentage < 50%.

[0165] III. Results

[0166] All patients in this group completed the Bianstone massage and herbal transdermal therapy as planned. The efficacy evaluation for abdominal distension showed that 21 cases (22.1%) were cured, 61 cases (64.2%) showed significant improvement, and 13 cases (13.7%) showed improvement. See Table 3 for details.

[0167] Table 3. Efficacy of treatment for abdominal distension symptoms in patients with chronic gastritis

[0168]

[0169] Typical cases

[0170] Case 1

[0171] Clinical Data: The patient was a 70-year-old male who was admitted to the hospital on July 21, 2025, with a chief complaint of "postprandial upper abdominal distension for 2 years, worsening for more than 4 months," diagnosed as "gastric fullness (liver-stomach qi stagnation syndrome) - chronic atrophic gastritis." Two years prior, the patient developed postprandial upper abdominal distension without any obvious cause, accompanied by shortness of breath and excessive salivation after eating. An endoscopy on May 31, 2024, revealed erosive gastritis and duodenitis, but no systematic treatment was given. Four months prior, the postprandial upper abdominal distension worsened without any obvious cause, accompanied by vomiting immediately after eating, frequent belching, and no difficulty swallowing. On April 21, 2025, a gastroscopy revealed esophagitis, chronic atrophic gastritis, duodenitis, and duodenal polyps. The patient was prescribed one sachet of sodium glutamate granules three times a day (tid), one tablet of compound azithromycin enteric-coated tablets three times a day (tid), one tablet of mosapride citrate three times a day (tid), and one tablet of rabeprazole sodium enteric-coated tablets once a day (qd) for one month, but the symptoms did not significantly improve. The patient's current symptoms are as follows: a feeling of fullness in the upper abdomen after meals, occasional vomiting of gastric contents immediately after eating, belching, no difficulty swallowing, excessive salivation, chest tightness and shortness of breath, no dizziness, headache, acid reflux, heartburn, bloating, or stomach pain. Sleep is normal, urination is difficult, stools are dry, bowel movements are every 2-3 days, difficult to pass, and the stool is dark in color. The patient has lost 10 kg in the past 3 months.

[0172] Nursing Assessment: The patient has a normal body size, experiences upper abdominal distension after meals, has dry stools (every 2-3 days), strains during defecation, and dark-colored stools. Before and after treatment, the patient's abdominal distension and constipation were assessed using Traditional Chinese Medicine (TCM) syndrome scores, with each score ranging from 0 to 5 points; lower scores indicate milder symptoms. The patient's perianal pain score was determined using the Visual Analogue Scale (VAS), ranging from 0 to 10 points. 0 points indicates no pain, 1-3 points indicate mild pain, 4-6 points indicate pain affecting sleep but still tolerable, and 7-10 points indicate unbearable pain. The patient's abdominal distension score was 3, constipation score was 3, and perianal pain score was 0.

[0173] Treatment plan: ① Finger acupressure: Assist the patient to lie supine, exposing the abdomen. Select the Shenque, Xiawan, Shangwan, Guanyuan, Zhongwan, and Qihai acupoints using the "finger-body inch acupoint selection method," pressing 26 points on each acupoint for 5 seconds. ② Abdominal massage: Preheat the Bianstone Tai Chi ball for 1 minute; apply an appropriate amount of the herbal ointment from Example 1 to the Bianstone Tai Chi ball and preheat for 15 seconds, then apply the ointment to the patient's abdomen; use the Bianstone Tai Chi ball to push and move slowly clockwise along the abdomen with a flat pushing method for about 1 minute; massage the abdomen clockwise with gentle techniques, paying attention to the patient's sensations, focusing on massaging the Qihai, Tianshu, Zhongwan, Shenque, and Guanyuan acupoints; after about 5 minutes, use the "rapid spiral walking method" to massage the abdomen clockwise along the patient's colon for one full cycle, then massage the abdomen clockwise again, gradually increasing the pressure, for 15 minutes. During the procedure, monitor the temperature of the Bianstone Tai Chi ball and adjust it according to the patient's sensation, keeping it between 60 and 80 degrees Celsius to prevent burns. Pay attention to the patient's sensations during the massage. ③ Apply medicine: After the massage, cover the abdomen with disposable plastic wrap and apply the herbal ointment for 30 minutes.

[0174] Treatment Results: After 14 interventions, the patient's abdomen was soft and without distension, and constipation symptoms significantly improved. The abdominal distension score and constipation score both decreased to 1 point, while the perianal pain score was 0. Constipation symptoms improved. A follow-up telephone consultation was conducted on August 12, 2025, after discharge, providing the patient with information on daily life and dietary precautions. The patient maintained a regular sleep schedule, had normal bowel movements, and did not experience constipation.

[0175] Case 2

[0176] Clinical Data: The patient is an 80-year-old female who was admitted to the hospital on July 22, 2025, with the chief complaint of "intermittent upper abdominal pain for half a year" and a diagnosis of "stomach pain (spleen and stomach damp-heat syndrome) - chronic gastritis". Six months prior, the patient developed upper abdominal pain without any obvious cause, mainly characterized by distending pain in the upper middle abdomen, which worsened after meals, accompanied by indigestion, dry mouth, and bitter taste. She had previously taken traditional Chinese medicine for four weeks, which slightly alleviated her symptoms, but the upper abdominal distending pain persisted. Current symptoms: distending pain in the upper middle abdomen, worsened after meals, indigestion, dry mouth, bitter taste, fair appetite and sleep, constipation (1-2 times daily), and frequent urination.

[0177] Nursing assessment: The patient was thin, with abdominal distension and constipation. Before and after treatment, the TCM syndrome scores for abdominal distension and constipation were calculated, with each item ranging from 0 to 5 points; lower scores indicated milder symptoms. The patient's perianal pain score was assessed using the Visual Analogue Scale (VAS), ranging from 0 to 10 points. 0 points indicated no pain, 1-3 points indicated mild pain, 4-6 points indicated pain affecting sleep but still tolerable, and 7-10 points indicated unbearable pain. The patient's abdominal distension score was 3, constipation score was 3, and perianal pain score was 3.

[0178] Treatment plan: ① Finger acupressure: Assist the patient to lie supine, exposing the abdomen. Select the Shenque, Xiawan, Shangwan, Guanyuan, Zhongwan, and Qihai acupoints using the "finger-body inch acupoint selection method," pressing 26 points on each acupoint for 5 seconds. ② Abdominal massage: Preheat the Bianstone Tai Chi ball for 1 minute; apply an appropriate amount of the herbal ointment from Example 1 to the Bianstone Tai Chi ball and preheat for 15 seconds, then apply the ointment to the patient's abdomen; use the Bianstone Tai Chi ball to push and move slowly clockwise along the abdomen with a flat pushing method for about 1 minute; massage the abdomen clockwise with gentle techniques, paying attention to the patient's sensations, focusing on massaging the Qihai, Tianshu, Zhongwan, Shenque, and Guanyuan acupoints; after about 5 minutes, use the "rapid spiral walking method" to massage the abdomen clockwise along the patient's colon for one full cycle, then massage the abdomen clockwise again, gradually increasing the pressure, for 15 minutes. During the procedure, monitor the temperature of the Bianstone Tai Chi ball and adjust it according to the patient's sensation, keeping it between 60 and 80 degrees Celsius to prevent burns. Pay attention to the patient's sensations during the massage. ③ Apply medicine: After the massage, cover the abdomen with disposable plastic wrap and apply the herbal ointment for 30 minutes.

[0179] Treatment Results: After 10 treatment sessions, the patient's abdomen was soft and without distension. The bitter taste in the mouth significantly improved, and there was no bad breath. Bowel movements occurred once daily. The abdominal distension score decreased to 1 point, the constipation score decreased to 1 point, and the perianal pain score decreased to 1 point. Constipation symptoms improved. A follow-up telephone consultation was conducted on August 12, 2025, after discharge, providing the patient with information on daily life and dietary precautions. The patient maintained a regular sleep schedule, normal bowel movements, and did not experience constipation.

[0180] Case 3

[0181] Clinical Data: The patient was a 39-year-old female who was admitted to the hospital on August 4, 2025, with a chief complaint of "intermittent stomach bloating for 6 years" and a diagnosis of "gastric fullness (spleen and stomach qi deficiency syndrome) - chronic atrophic gastritis". Six years prior, the patient experienced abdominal bloating, stomach pain, acid reflux, and heartburn due to irregular eating habits. In July 2024, she was hospitalized for colonic polyps, diagnosed with: chronic atrophic gastritis, a personal history of colonic polyps, multiple non-toxic thyroid nodules, breast hyperplasia, liver cysts, kidney stones, and mixed hemorrhoids. A painless colonoscopy was performed, revealing: 1. Mild esophageal sphincter relaxation (GEFV Grade 1); 2. Chronic superficial gastritis with goosebump-like gastritis (recovery phase), accompanied by erosion (healing phase), and bile reflux; 3. Helicobacter pylori negative. Recently, the patient's stomach bloating has worsened, with occasional stomach pain, but no acid reflux or heartburn. The patient presented with the following symptoms upon admission: 1-2 bowel movements per day, loose stools, intermittent bloating, aggravated by eating raw or cold foods, preference for hot water, occasional stomach pain, normal appetite but poor sleep. There had been no significant recent weight change.

[0182] Nursing assessment: The patient has a normal body size, intermittent episodes of abdominal distension, and loose stools. Before and after treatment, the TCM syndrome scores for abdominal distension and constipation were calculated, with each item ranging from 0 to 5 points; lower scores indicate milder symptoms. The patient's perianal pain score was assessed using the Visual Analogue Scale (VAS), ranging from 0 to 10 points. 0 points indicates no pain, 1-3 points indicate mild pain, 4-6 points indicate pain affecting sleep but still tolerable, and 7-10 points indicate unbearable pain. The patient's abdominal distension score was 3, constipation score was 3, and perianal pain score was 3.

[0183] Treatment plan: ① Finger acupressure: Assist the patient to lie supine, exposing the abdomen. Select the Shenque, Xiawan, Shangwan, Guanyuan, Zhongwan, and Qihai acupoints using the "finger-body inch acupoint selection method," pressing 26 points on each acupoint for 5 seconds. ② Abdominal massage: Preheat the Bianstone Tai Chi ball for 1 minute; apply an appropriate amount of the herbal ointment from Example 1 to the Bianstone Tai Chi ball and preheat for 15 seconds, then apply the ointment to the patient's abdomen; use the Bianstone Tai Chi ball to push and move slowly clockwise along the abdomen with a flat pushing method for about 1 minute; massage the abdomen clockwise with gentle techniques, paying attention to the patient's sensations, focusing on massaging the Qihai, Tianshu, Zhongwan, Shenque, and Guanyuan acupoints; after about 5 minutes, use the "rapid spiral walking method" to massage the abdomen clockwise along the patient's colon for 1 week, then massage the abdomen clockwise again, gradually increasing the pressure, for 15 minutes. During the procedure, monitor the temperature of the Bianstone Tai Chi ball and adjust it according to the patient's sensation, keeping it between 60 and 80 degrees Celsius to prevent burns. Pay attention to the patient's sensations during the massage. ③ Apply medicine: After the massage, cover the abdomen with disposable plastic wrap and apply the herbal ointment for 30 minutes.

[0184] Treatment Results: After three treatment sessions, the patient's abdomen was soft and not distended, with one bowel movement per day. The abdominal distension score, constipation score, and perianal pain score all decreased to 1 point. Constipation symptoms improved. A follow-up telephone consultation was conducted on August 11, 2025, after discharge, providing the patient with information on daily life and dietary precautions. The patient maintained a regular sleep schedule, normal bowel movements, and did not experience constipation.

[0185] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A paste-like dressing for strengthening the spleen, replenishing qi, and relieving stagnation, wherein, The ointment-like dressing comprises active ingredients and a matrix. The active ingredients include the following components: Lindera root, Angelica dahurica, Zanthoxylum bungeanum, processed Aconitum carmichaelii, dried ginger, Ligusticum chuanxiong, Aucklandia lappa, and Spatholobus suberectus.

2. The ointment dressing according to claim 1, wherein, The active ingredients comprise the following components by weight: Lindera root 0.1-10 parts, Angelica dahurica root 1-15 parts, Zanthoxylum bungeanum root 1-15 parts, processed Aconitum carmichaelii rhizome 0.01-5 parts, dried ginger 0.1-10 parts, Ligusticum chuanxiong rhizome 0.1-10 parts, Aucklandia lappa root 0.1-10 parts, and Spatholobus suberectus root 0.1-10 parts; Preferably, the active ingredients include the following components by weight: 2 parts of Lindera strychnifolia, 4 parts of Angelica dahurica, 4 parts of Zanthoxylum bungeanum, 1 part of processed Aconitum carmichaelii, 2 parts of dried ginger, 2 parts of Ligusticum chuanxiong, 2 parts of Aucklandia lappa, and 2 parts of Spatholobus suberectus.

3. The ointment dressing according to claim 1, wherein, The mass ratio of the active ingredient to the matrix is ​​1:(1-10); And / or, wherein the matrix comprises petrolatum and paraffin oil; Preferably, the matrix is ​​petrolatum and paraffin oil; More preferably, the mass of the paraffin oil is 1 to 50 wt% of the sum of the mass of the active ingredient and the petrolatum; preferably 10 wt%.

4. A method for preparing the ointment dressing according to any one of claims 1 to 3, comprising: The active ingredients are pulverized separately and then mixed according to the prescription ratio to obtain a mixed fine powder. The matrix is ​​heated until completely melted, and the mixed fine powder is then homogenized with the molten matrix. Cooling yields a paste-like dressing.

5. The preparation method according to claim 4, wherein the temperature for heating the matrix is ​​60–90°C; and / or, The temperature for mixing and homogenizing is 50–80°C.

6. The preparation method according to claim 4 or 5, wherein the cooling process includes a first cooling stage and a second cooling stage, and the cooling rate of the first cooling stage is greater than the cooling rate of the second cooling stage; Preferably, the cooling rate in the first cooling stage is 0.8–1.5 °C / min; and / or The cooling rate in the second cooling stage is 0.2–0.7 °C / min; Preferably, during the first cooling stage, the temperature is reduced to 42–48°C; and / or During the first cooling phase, the temperature is reduced to 25–30°C.

7. The use of the ointment dressing according to any one of claims 1 to 3, or the ointment dressing prepared by any one of claims 4 to 6, in the preparation of percutaneous therapeutic medical devices, wherein, The percutaneous medical device includes a carrier and the ointment dressing loaded on the carrier; Preferably, the carrier is selected from any one or more of medical nonwoven fabric, polymer film, silicone substrate, metal foil, polymer foil or pressure-sensitive adhesive patch; More preferably, the surface of the carrier layer is physically or chemically treated to enhance the adhesion of the ointment dressing.

8. A percutaneous therapeutic medical device, wherein, The medical device includes a carrier and a paste dressing according to any one of claims 1 to 3 loaded on the carrier, or a paste dressing prepared by any one of claims 4 to 6.

9. A nursing care kit, wherein, The nursing kit includes a matching ironing and rubbing stone, and a paste dressing as described in any one of claims 1 to 3 or a paste dressing prepared by any one of claims 4 to 6; Preferably, the ironing stone has an integrated heating element inside; The heating element regulates the surface temperature of the Bianstone to 55-65°C through resistance heating.

10. The nursing kit according to claim 9, wherein the method of using the ironing stone and the ointment dressing together includes: First, apply a paste-like dressing to the skin surface, then use a Bian stone for targeted ironing and massage; And / or, A paste-like dressing is pre-coated onto the surface of the Bian stone, and simultaneous drug delivery and physiotherapy are achieved through heating and / or pressure.

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