Nystatin solution, its preparation method and application

By using a complex solvent system of dimethyl sulfoxide and 1,2-propanediol, along with the antioxidant vitamin E, the problem of nystatin's poor solubility was solved, enabling a highly efficient and rapid method of administration to poultry, improving treatment efficacy and cure rate, and making it suitable for modern farming.

CN121265533BActive Publication Date: 2026-06-26JINAN GUANGSHENGYUAN BIOTECH
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Patent Information

Application Number
CN202511616685.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-11-06
Publication Date
2026-06-26
Estimated Expiration
2045-11-06

AI Technical Summary

Technical Problem

In the existing technology, nystatin is difficult to dissolve in water, making it impossible to prepare high-concentration solutions. The administration method is time-consuming and laborious, and existing veterinary drug products are not suitable for poultry fungal diseases or have poor effects, affecting treatment efficiency.

Method used

A complex solvent system of dimethyl sulfoxide and 1,2-propanediol is used, with the addition of antioxidant vitamin E, to form a clear and stable solution, ensuring complete dissolution of nystatin, suitable for administration to poultry drinking water.

Benefits of technology

It enables rapid drug administration with high bioavailability, improves cure rate, adapts to modern farming models, reduces stress response, ensures sufficient drinking water and adequate drug intake for poultry, and improves prevention and control efficiency.

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Abstract

The application discloses a nystatin solution and a preparation method and application thereof, which is prepared from the following raw materials in parts by weight: nystatin 20-50 parts, dimethyl sulfoxide 110-220 parts, preservative 1.5-2.0 parts, antioxidant 0.5-1 part and 1,2-propylene glycol 737-880 parts. The application creatively adopts a composite solvent system of dimethyl sulfoxide and propylene glycol, utilizes the extremely strong dissolving capacity of dimethyl sulfoxide and the auxiliary solubilization and dilution effect of propylene glycol, and produces a significant synergistic effect. The system can completely dissolve up to 50 parts by weight of nystatin, forms a clear, transparent and uniform stable solution, fundamentally solves the technical bottleneck that nystatin cannot be prepared into a high-content solution due to poor water solubility, and lays a foundation for poultry group water medication.
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