Nine-constitution customized medicine moxibustion stick formula considering safety and efficacy and preparation method

Abstract

The invention relates to the technical field of traditional Chinese medicine moxibustion, in particular to a customized medicinal moxibustion stick formula for nine constitutions considering safety and efficacy, which is specially designed for the nine constitutions (yang deficiency, yin deficiency, qi deficiency, phlegm dampness, damp heat, blood stasis, qi depression, specific endowment and mild constitutions) in the traditional Chinese medicine. All the formulas follow the safety standard that the main drug accounts for 25-50%, the number of adjuvant drugs is less than or equal to 5, the single adjuvant drug accounts for less than or equal to 25% (the number of toxic drugs is less than or equal to 10%), and the total number of the drugs is 4-6; a special formula is designed for nine constitutions, for example, for a yang deficiency formula, a combination of folium artemisiae argyi, cortex cinnamomi and radix angelicae is used for enhancing the yang warming effect without dryness-heat risk, for a yin deficiency formula, a hierarchical yin nourishing scheme of folium mori and radix rehmanniae recen is used for improving the problem of excessive internal heat, and the clinical conditioning effective rate is increased to 85% or above (based on the traditional Chinese medicine constitution scoring standard, the traditional Chinese medicine composition has no toxic or side effect). The physique deviation degree after conditioning is reduced by more than or equal to 40%).

Description

Technical Field

[0001] This invention relates to the field of moxibustion technology in traditional Chinese medicine, specifically to customized moxibustion stick formulas and manufacturing methods for nine different body constitutions that balance safety and efficacy. Background Technology

[0002] Moxibustion, as a traditional Chinese medicine external therapy, exerts its therapeutic effect through heat stimulation and drug penetration. However, existing medicated moxibustion stick products have the following technical defects:

[0003] Poor compatibility with body constitution: Most medicated moxibustion sticks use fixed formulas and are not designed to take into account the differences in the nine types of body constitutions in traditional Chinese medicine. For example, when a warm medicated moxibustion stick designed for Yang deficiency is used for Yin deficiency, it is easy to cause problems such as "internal heat" and "dryness and heat damaging Yin", which cannot meet the needs of personalized conditioning.

[0004] Significant safety risks: Some formulas contain an excessively high proportion of highly potent medicinal materials (such as cinnamon and phellodendron bark), or the dosage of toxic medicinal materials is not strictly controlled, which can easily lead to adverse reactions such as skin burns and damage to the spleen and stomach; at the same time, the medicinal materials have not passed biocompatibility tests, which may trigger immune rejection in people with allergies.

[0005] Imbalance between efficacy and safety: In pursuit of efficacy, traditional formulas often increase the number of medicinal ingredients (more than 6), leading to conflicts between the effects of the ingredients, or excessively reduce the proportion of medicinal ingredients (less than 20%), which greatly reduces the conditioning effect.

[0006] Non-standard manufacturing process: uneven mixing of medicinal powder and moxa wool, and large differences in molding density, result in drastic temperature fluctuations during combustion, affecting the efficiency of drug penetration and increasing the risk of burns. To address this, we propose customized moxibustion stick formulas and manufacturing methods for nine different body constitutions that balance safety and efficacy. Summary of the Invention

[0007] In view of this, the present invention provides customized moxibustion stick formulas and manufacturing methods for nine different body constitutions that take into account both safety and efficacy, in order to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial alternative.

[0008] The technical solution of this invention is achieved as follows: a customized moxibustion strip formula for nine different body constitutions that balances safety and efficacy. The key feature is that: a special formula is designed for each of the nine body constitutions in traditional Chinese medicine (Yang deficiency, Yin deficiency, Qi deficiency, phlegm-dampness, damp-heat, blood stasis, Qi stagnation, special constitution, and balanced constitution). All formulas follow the safety standards of "main medicine accounting for 25% to 50%, adjuvant medicines ≤ 5 kinds, single adjuvant medicine accounting for ≤ 25% (toxic medicines ≤ 10%), and a total number of medicines 4 to 6".

[0009] The specific formulas for each body type are as follows:

[0010] Formula for Yang deficiency constitution: The powder contains 14% mugwort, 2% cinnamon, 2% dried ginger, 2% epimedium, 2% fennel, 3% angelica dahurica, and 75% mugwort floss;

[0011] Formula for Yin Deficiency Constitution: The powder contains 10% mulberry leaf, 5% privet fruit, 4% Solomon's seal, 2% ophiopogon japonicus, 2% anemarrhena asphodeloides, 2% rehmannia glutinosa, and 75% mugwort floss;

[0012] Formula for Qi deficiency constitution: The powder contains 13% Astragalus membranaceus, 5% Codonopsis pilosula, 2% Atractylodes macrocephala, 2% Glycyrrhiza uralensis, 1% Cimicifuga foetida, 2% Poria cocos, and 75% Artemisia argyi.

[0013] Formula for phlegm-dampness constitution: The powder contains 10% Atractylodes lancea, 5% Poria cocos, 4% Magnolia officinalis, 3% Citrus medica, 1% Pinellia ternata, 2% Amomum villosum, and 75% Artemisia argyi.

[0014] Formula for damp-heat constitution: The powder contains 15% Phellodendron bark, 3% Gardenia fruit, 3% Coix seed, 2% Alisma rhizome, 1% Eupatorium fortunei, 1% prepared licorice root, and 75% Artemisia flakes;

[0015] Formula for blood stasis constitution: The powder contains 15% safflower, 5% salvia miltiorrhiza, 2% chuanxiong, 1% peach kernel, 1% angelica sinensis, 1% notoginseng powder, and 75% mugwort floss;

[0016] Formula for Qi stagnation constitution: The powder contains 14% Bupleurum, 5% Cyperus, 3% Curcuma, 2% Rose, 1% Peppermint, and 75% Artemisia flakes;

[0017] Formula for individuals with special constitutions: The powder contains 15% Saposhnikovia divaricata, 5% Prunus mume, 3% Cynanchum paniculatum, 1% Glycyrrhiza uralensis, 1% Astragalus membranaceus, and 75% Artemisia argyi.

[0018] Formula for those with a balanced constitution: The powder contains 18% mugwort, 2% chrysanthemum, 2% goji berries, 1% dried tangerine peel, 1% poria cocos, 1% yam powder, and 75% mugwort floss.

[0019] Further preferably, the mugwort leaves are aged mugwort stored for more than 3 years, and the mugwort floss is selected with a purity of 30:1 (30kg of mugwort leaves to extract 1kg of mugwort floss); some medicinal materials need to be pre-treated: the dried ginger is stir-fried at 120℃ for 10 minutes, the roasted licorice is stir-fried with honey (honey: licorice = 1:5) at 110℃ for 15 minutes, and the raw rehmannia root is sliced, dried at 60℃ for 2 hours, and then pulverized.

[0020] For further optimization, each formula has its own specific safety control requirements:

[0021] Formula for those with Yang deficiency constitution: Contraindicated for patients with hypertension;

[0022] Formula for Yin deficiency constitution: Use low-temperature moxibustion at 40-45℃; discontinue use if diarrhea occurs.

[0023] Special formula for individuals with allergies: A skin test must be performed on the inside of the user's forearm before use (apply the powder solution; if no redness or swelling occurs within 24 hours, it can be used).

[0024] Formula for those with balanced constitution: Use 1-2 times per month, 1 vial each time.

[0025] A customized moxibustion stick manufacturing method that balances safety and efficacy for nine different body constitutions includes the following steps:

[0026] Step 1: Pre-treatment of medicinal materials

[0027] Select medicinal materials that meet the standards, remove impurities, and pulverize mugwort and other medicinal materials to 80-100 mesh. Pre-treat dried ginger, roasted licorice root, and raw rehmannia root according to the method described in claim 2. All medicinal material powders are screened through a 100-mesh sieve.

[0028] Step 2: Mix the medicinal powder with the moxa wool

[0029] Weigh the medicinal powder and mugwort floss according to the formula ratio described in claim 1, place them in a three-dimensional mixer, set the rotation speed to 30 r / min and the mixing time to 20 minutes, and the mixing uniformity is ≥95% (samples from 3 different parts were tested, and the deviation of medicinal powder content was ≤3%).

[0030] Step 3: Molding and processing

[0031] The mixed medicinal moxa material is fed into a moxa stick forming machine. The mold diameter is set to 14mm, 18mm, or 22mm, the forming pressure is 0.8MPa, the drying temperature is 50℃, and the drying time is 3 hours. The density of the formed moxa stick is controlled between 0.8 and 1.0 g / cm³. 3 Continuous burning time ≥ 2 hours / piece;

[0032] Step 4: Quality Inspection and Packaging

[0033] Ten moxibustion sticks were randomly selected from each batch for testing: the tests were conducted to check for medicinal material residues (heavy metals ≤ 5 mg / kg, pesticide residues ≤ 0.1 mg / kg) and harmful substances in the combustion smoke (carbon monoxide ≤ 10 mg / m³). 3 Formaldehyde ≤0.1mg / m³ 3 The content of the active ingredients of the main medicine is detected by high performance liquid chromatography (HPLC) (cinnamaldehyde ≥1.0% for Yang deficiency formula, rutin ≥0.5% for Yin deficiency formula); qualified products are individually packaged in waterproof and moisture-proof packaging, and are labeled with body constitution type, instructions for use, contraindications, production date, batch number and 2-year shelf life.

[0034] More preferably, the mixing parameters of the three-dimensional mixer in step 2 can be finely adjusted according to the total amount of powder: when the total amount of powder is ≤5kg, the mixing time is maintained at 20 minutes; when the total amount of powder is >5kg, the mixing time is extended by 2 minutes for every additional 1kg of powder, to ensure that the mixing uniformity is still ≥95%.

[0035] More preferably, the drying temperature of the molding machine in step 3 can be adjusted according to the ambient humidity: when the ambient humidity is ≤60%, the drying temperature is 50℃ and the time is 3 hours; when the ambient humidity is >60%, the drying temperature is increased to 55℃ and the time is extended to 3.5 hours to ensure that the moisture content of the medicated moxa stick after molding is ≤8%.

[0036] More preferably, the quality inspection in step 4 also includes combustion temperature inspection: after the moxibustion stick is lit, the temperature is measured at a distance of 3cm from the burning end using a thermocouple thermometer. The combustion temperature needs to be stable at 380-420℃, with a temperature fluctuation range of ≤±10℃.

[0037] These moxibustion sticks are customized for nine different body types, balancing safety and efficacy. Each stick contains 8-10g of medicinal powder and 24-30g of moxa wool. They are suitable for traditional Chinese medicine health care, home wellness, and professional moxibustion therapy. They should be used no more than three times a week (except for those with a balanced body type).

[0038] Further optimization involves setting up specific moxibustion methods for different body constitutions: mild moxibustion (moxibustion distance from the skin is 3-5cm) is used for Yang deficiency, Qi deficiency, and phlegm-dampness constitutions; sparrow-pecking moxibustion (moxibustion distance from the skin is 5-7cm) is used for Yin deficiency and damp-heat constitutions.

[0039] Further optimized, the outer packaging of the moxibustion sticks features clear color blocks indicating body constitution: red for Yang deficiency, blue for Yin deficiency, yellow for Qi deficiency, brown for phlegm-dampness, green for damp-heat, purple for blood stasis, orange for Qi stagnation, gray for special constitution, and white for balanced constitution, making it easy for users to quickly identify the appropriate body constitution.

[0040] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions:

[0041] I. This invention is precisely tailored to different body constitutions and has significant effects: It designs exclusive formulas for nine different body constitutions. For example, the formula for Yang deficiency enhances the warming effect of Yang through the combination of mugwort, cinnamon and angelica without the risk of dryness and heat. The formula for Yin deficiency improves the problem of "internal heat" through the layered Yin-nourishing plan of mulberry leaf and rehmannia root. The clinical treatment effectiveness rate has been increased to more than 85% (based on the TCM body constitution scoring standard, the deviation of the body constitution after treatment is reduced by ≥40%).

[0042] Second, this invention reduces the skin burn rate to below 0.5% and the incidence of allergic reactions to below 0.3% by screening medicinal materials (biocompatibility testing), controlling dosage (toxicity ≤10%), and buffering medicinal properties (such as using roasted licorice to balance bitterness and coldness), thus solving the problem of "high side effects" of traditional moxibustion sticks.

[0043] The three-dimensional mixing and precision molding process ensures that the medicinal powder is evenly distributed and the burning temperature is stable for each moxibustion stick, with the difference in the amount of effective ingredients penetrating being ≤5%, thus avoiding quality fluctuations in handmade products.

[0044] Fourth, it is suitable for "body constitution identification and moxibustion" physiotherapy in professional medical institutions, and can also meet the health care needs of families through clear body constitution identification and instructions for use, thus lowering the threshold for TCM body constitution identification and moxibustion operation.

[0045] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0046] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0047] Figure 1 This is a schematic diagram of the manufacturing process of the moxibustion sticks of the present invention. Detailed Implementation

[0048] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.

[0049] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0050] like Figure 1As shown, this invention provides customized moxibustion stick formulas for nine different body constitutions that balance safety and efficacy. The key feature is that each of the nine traditional Chinese medicine constitutions (Yang deficiency, Yin deficiency, Qi deficiency, phlegm-dampness, damp-heat, blood stasis, Qi stagnation, special constitution, and balanced constitution) is designed with a unique formula. All formulas adhere to the safety standards of "main ingredient proportion 25%–50%, adjuvant herbs ≤ 5 types, single adjuvant herb proportion ≤ 25% (toxic herbs ≤ 10%), and total number of herbs 4–6."

[0051] The specific formulas for each body type are as follows:

[0052] Formula for Yang deficiency constitution: The powder contains 14% mugwort, 2% cinnamon, 2% dried ginger, 2% epimedium, 2% fennel, 3% angelica dahurica, and 75% mugwort floss;

[0053] Formula for Yin Deficiency Constitution: The powder contains 10% mulberry leaf, 5% privet fruit, 4% Solomon's seal, 2% ophiopogon japonicus, 2% anemarrhena asphodeloides, 2% rehmannia glutinosa, and 75% mugwort floss;

[0054] Formula for Qi deficiency constitution: The powder contains 13% Astragalus membranaceus, 5% Codonopsis pilosula, 2% Atractylodes macrocephala, 2% Glycyrrhiza uralensis, 1% Cimicifuga foetida, 2% Poria cocos, and 75% Artemisia argyi.

[0055] Formula for phlegm-dampness constitution: The powder contains 10% Atractylodes lancea, 5% Poria cocos, 4% Magnolia officinalis, 3% Citrus medica, 1% Pinellia ternata, 2% Amomum villosum, and 75% Artemisia argyi.

[0056] Formula for damp-heat constitution: The powder contains 15% Phellodendron bark, 3% Gardenia fruit, 3% Coix seed, 2% Alisma rhizome, 1% Eupatorium fortunei, 1% prepared licorice root, and 75% Artemisia flakes;

[0057] Formula for blood stasis constitution: The powder contains 15% safflower, 5% salvia miltiorrhiza, 2% chuanxiong, 1% peach kernel, 1% angelica sinensis, 1% notoginseng powder, and 75% mugwort floss;

[0058] Formula for Qi stagnation constitution: The powder contains 14% Bupleurum, 5% Cyperus, 3% Curcuma, 2% Rose, 1% Peppermint, and 75% Artemisia flakes;

[0059] Formula for individuals with special constitutions: The powder contains 15% Saposhnikovia divaricata, 5% Prunus mume, 3% Cynanchum paniculatum, 1% Glycyrrhiza uralensis, 1% Astragalus membranaceus, and 75% Artemisia argyi.

[0060] Formula for those with a balanced constitution: The powder contains 18% mugwort, 2% chrysanthemum, 2% goji berries, 1% dried tangerine peel, 1% poria cocos, 1% yam powder, and 75% mugwort floss.

[0061] In one embodiment, the mugwort leaves are selected from aged mugwort stored for more than 3 years, and the mugwort floss is selected with a purity of 30:1 (30kg of mugwort leaves to extract 1kg of mugwort floss); some medicinal materials need to be pre-treated: dried ginger is stir-fried at 120℃ for 10 minutes, roasted licorice is stir-fried with honey (honey: licorice = 1:5) at 110℃ for 15 minutes, and raw rehmannia root is sliced, dried at 60℃ for 2 hours, and then pulverized.

[0062] In one embodiment, specific safety control requirements are set for each formulation:

[0063] Formula for those with Yang deficiency constitution: Contraindicated for patients with hypertension;

[0064] Formula for Yin deficiency constitution: Use low-temperature moxibustion at 40-45℃; discontinue use if diarrhea occurs.

[0065] Special formula for individuals with allergies: A skin test must be performed on the inside of the user's forearm before use (apply the powder solution; if no redness or swelling occurs within 24 hours, it can be used).

[0066] Formula for those with balanced constitution: Use 1-2 times per month, 1 vial each time.

[0067] A customized moxibustion stick manufacturing method that balances safety and efficacy for nine different body constitutions includes the following steps:

[0068] Step 1: Pre-treatment of medicinal materials

[0069] Select medicinal materials that meet the standards, remove impurities, and pulverize mugwort and other medicinal materials to 80-100 mesh. Pre-treat dried ginger, roasted licorice root, and raw rehmannia root according to claim 2. All medicinal material powders are screened through a 100-mesh sieve.

[0070] Step 2: Mix the medicinal powder with the moxa wool

[0071] Weigh the medicinal powder and mugwort floss according to the formula ratio of claim 1, place them in a three-dimensional mixer, set the speed to 30 r / min and the mixing time to 20 minutes, and the mixing uniformity is ≥95% (samples from 3 different parts were tested, and the deviation of medicinal powder content was ≤3%).

[0072] Step 3: Molding and processing

[0073] The mixed medicinal moxa material is fed into a moxa stick forming machine. The mold diameter is set to 14mm, 18mm, or 22mm, the forming pressure is 0.8MPa, the drying temperature is 50℃, and the drying time is 3 hours. The density of the formed moxa stick is controlled between 0.8 and 1.0 g / cm³. 3 Continuous burning time ≥ 2 hours / piece;

[0074] Step 4: Quality Inspection and Packaging

[0075] Ten moxibustion sticks were randomly selected from each batch for testing: the tests were conducted to check for medicinal material residues (heavy metals ≤ 5 mg / kg, pesticide residues ≤ 0.1 mg / kg) and harmful substances in the combustion smoke (carbon monoxide ≤ 10 mg / m³). 3 Formaldehyde ≤0.1mg / m³ 3 The content of the active ingredients of the main medicine is detected by high performance liquid chromatography (HPLC) (cinnamaldehyde ≥1.0% for Yang deficiency formula, rutin ≥0.5% for Yin deficiency formula); qualified products are individually packaged in waterproof and moisture-proof packaging, and are labeled with body constitution type, instructions for use, contraindications, production date, batch number and 2-year shelf life.

[0076] In one embodiment, the mixing parameters of the three-dimensional mixer in step 2 can be finely adjusted according to the total amount of powder: when the total amount of powder is ≤5kg, the mixing time is maintained at 20 minutes; when the total amount of powder is >5kg, the mixing time is extended by 2 minutes for every additional 1kg of powder, to ensure that the mixing uniformity is still ≥95%.

[0077] In one embodiment, the drying temperature of the molding machine in step 3 can be adjusted according to the ambient humidity: when the ambient humidity is ≤60%, the drying temperature is 50℃ and the time is 3 hours; when the ambient humidity is >60%, the drying temperature is increased to 55℃ and the time is extended to 3.5 hours to ensure that the moisture content of the medicated moxa stick after molding is ≤8%.

[0078] In one embodiment, the quality inspection in step 4 also includes combustion temperature detection: after the moxibustion stick is lit, the temperature is detected at a distance of 3cm from the burning end using a thermocouple thermometer. The combustion temperature needs to be stable at 380-420℃, and the temperature fluctuation range is ≤±10℃.

[0079] These moxibustion sticks are customized for nine different body types, balancing safety and efficacy. Each stick contains 8-10g of medicinal powder and 24-30g of moxa wool. They are suitable for traditional Chinese medicine health care, home wellness, and professional moxibustion therapy. They should be used no more than three times a week (except for those with a balanced body type).

[0080] In one embodiment, specific moxibustion methods are set for different constitutions: mild moxibustion (moxibustion distance from the skin is 3-5cm) is used for Yang deficiency, Qi deficiency, and phlegm-dampness constitutions; sparrow-pecking moxibustion (moxibustion distance from the skin is 5-7cm) is used for Yin deficiency and damp-heat constitutions.

[0081] In one embodiment, the outer packaging of the moxibustion stick features clear color blocks indicating body constitution: red for Yang deficiency, blue for Yin deficiency, yellow for Qi deficiency, brown for phlegm-dampness, green for damp-heat, purple for blood stasis, orange for Qi stagnation, gray for special constitution, and white for balanced constitution, making it easy for users to quickly identify the appropriate body constitution.

[0082] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A nine-constitution customized moxibustion stick formula that balances safety and efficacy, characterized in that: The nine TCM constitutions (yang deficiency, yin deficiency, qi deficiency, phlegm-dampness, damp-heat, blood stasis, qi depression, special constitution, and balanced constitution) are designed with exclusive formulas, and all formulas follow the safety guidelines of "25-50% of main drugs, ≤5 kinds of auxiliary drugs, ≤25% of single auxiliary drug (≤10% of toxic drugs), and 4-6 total drug flavors"; The specific formulas for each constitution are as follows: Yang deficiency constitution formula: medicinal powder contains 14% of mugwort leaves, 2% of cinnamon, 2% of dried ginger, 2% of herba epimedii, 2% of cumin, and 3% of radix angelicae pubescentis, and the proportion of moxa is 75%; Yin deficiency constitution formula: medicinal powder contains 10% of folium mori, 5% of ligustrum lucidum, 4% of polygonatum, 2% of ophiopogon japonicus, 2% of radix anemarrhenae, and 2% of radix rehmanniae, and the proportion of moxa is 75%; Qi deficiency constitution formula: medicinal powder contains 13% of radix astragali, 5% of radix codonopsitis, 2% of atractylodes, 2% of licorice, 1% of radix angelicae sinensis, and 2% of poria cocos, and the proportion of moxa is 75%; Phlegm-dampness constitution formula: medicinal powder contains 10% of atractylodes lancea, 5% of poria cocos, 4% of magnolia officinalis, 3% of citrus medica, 1% of rhizoma pinelliae, and 2% of amomum villosum, and the proportion of moxa is 75%; Damp-heat constitution formula: medicinal powder contains 15% of cortex phellodendri, 3% of gardenia, 3% of coix, 2% of alisma orientalis, 1% of pterocephalus incanus, and 1% of licorice, and the proportion of moxa is 75%; Blood stasis constitution formula: medicinal powder contains 15% of safflower, 5% of salvia miltiorrhiza, 2% of ligusticum wallichii, 1% of peony, 1% of angelica sinensis, and 1% of panax notoginseng, and the proportion of moxa is 75%; Qi depression constitution formula: medicinal powder contains 14% of bupleurum, 5% of cyperus rotundus, 3% of curcuma, 2% of rosa rugosa, and 1% of mentha haplocalyx, and the proportion of moxa is 75%; Special constitution formula: medicinal powder contains 15% of saposhnikovia divaricata, 5% of prunus mume, 3% of radix stephaniae tetrandrae, 1% of licorice, and 1% of radix astragali, and the proportion of moxa is 75%; Balanced constitution formula: medicinal powder contains 18% of mugwort leaves, 2% of chrysanthemum, 2% of lycium chinense, 1% of pericarpium citri reticulatae, 1% of poria cocos, and 1% of dioscorea, and the proportion of moxa is 75%.

2. The customized moxibustion stick formula for nine different body constitutions, which balances safety and efficacy, as described in claim 1, is characterized in that: The mugwort leaves are stored for more than 3 years, and the moxa is selected with a purity of 30:1 (30 kg of mugwort leaves extract 1 kg of moxa); some medicinal materials need to be pretreated: the dried ginger is fried at 120°C for 10 minutes, the licorice is mixed with honey (honey: licorice = 1:5) and fried at 110°C for 15 minutes, and the radix rehmanniae is cut into slices, dried at 60°C for 2 hours, and then crushed. 3.The customized nine-constitution pharmacomugwort stick of claim 1, wherein the customized nine-constitution pharmacomugwort stick is formulated by mixing the nine-constitution pharmacomugwort sticks of Table 1. Each formula has exclusive safety control requirements: Yang deficiency constitution formula: not suitable for patients with hypertension; Yin deficiency constitution formula: use low-temperature moxibustion at 40-45°C, and stop using when diarrhea occurs; Special constitution formula: skin test is required on the inside of the user's forearm before use (apply medicinal powder solution, and use if there is no redness and swelling after 24 hours); Balanced constitution formula: use 1-2 times per month, and use 1 stick each time.

4. The method for making the nine-constitution customized moxibustion stick with safety and efficacy, which is matched with the nine-constitution customized moxibustion stick formula with safety and efficacy according to any one of claims 1-3, characterized in that: The steps include: Step 1: medicinal material pretreatment Select medicinal materials that meet the standards, remove impurities, and then grind the mugwort leaves and other medicinal materials to 80-100 mesh. Pretreat the dried ginger, licorice, and radix rehmanniae as described in claim 2. Screen all medicinal powder through a 100 mesh sieve; Step 2: mix medicinal powder with moxa According to the proportion of claim 1, the medicine powder and moxa are weighed and placed in a three-dimensional mixer, the rotating speed is set to 30 r / min, the mixing time is 20 minutes, and the uniformity of mixing is ≥95% (sampling detection of 3 different parts of the sample, the content deviation of the medicine powder is ≤3%); Step 3: molding processing The mixed medicine moxa is sent into a moxa stick forming machine, the die diameter is set to 14 mm, 18 mm or 22 mm, the forming pressure is 0.8 MPa, the drying temperature is 50 DEG C, the drying time is 3 hours, and the density of the formed medicine moxa stick is controlled to 0.8-1.0 g / cm 3 , and the continuous burning time is greater than or equal to 2 hours per stick. Step 4: quality detection and packaging 10 sticks of each batch were randomly selected for testing: testing of medicinal material residues (heavy metals ≤5 mg / kg, pesticide residues ≤0.1 mg / kg), harmful substances in combustion smoke (carbon monoxide ≤10 mg / m 3 , formaldehyde ≤0.1 mg / m 3 ); testing of the content of effective components in main drugs by high performance liquid chromatography (HPLC) (cinnamyl aldehyde ≥1.0% for yang deficiency formula, rutin ≥0.5% for yin deficiency formula); qualified products were packaged with waterproof and moisture-proof independent packaging, and were labeled with physical type, usage instruction, contraindication, production date, batch and 2-year shelf life.

5. The method for making customized nine-constitution pharmacomoxibustion sticks with safety and efficacy according to claim 4, characterized in that: The mixing parameters of the three-dimensional mixer in step 2 can be adjusted according to the total amount of the medicine powder: when the total amount of the medicine powder is ≤5 kg, the mixing time is kept at 20 minutes; when the total amount of the medicine powder is >5 kg, the mixing time is extended by 2 minutes for every additional 1 kg of medicine powder, to ensure that the uniformity of mixing is still ≥95%.

6. The method for making customized nine-constitution pharmacomoxibustion sticks with safety and efficacy according to claim 4, characterized in that: The drying temperature of the molding machine in step 3 can be adjusted according to the environmental humidity: when the environmental humidity is ≤60%, the drying temperature is 50°C and the time is 3 hours; when the environmental humidity is >60%, the drying temperature is increased to 55°C and the time is extended to 3.5 hours, to ensure that the moisture content of the moxa stick after molding is ≤8%.

7. The method for making customized nine-constitution pharmacomoxibustion sticks with safety and efficacy according to claim 4, characterized in that: The quality detection in step 4 also includes combustion temperature detection: after the moxa stick is ignited, the temperature is detected at a distance of 3 cm from the burning end using a thermocouple thermometer, and the combustion temperature needs to be stable at 380-420°C, with a temperature fluctuation range of ≤±10°C.

8. The nine-constitution customized moxa stick with safety and efficacy, which is prepared by the method of any one of claims 4-7, characterized in that: Each moxa stick contains 8-10 g of medicine powder and 24-30 g of moxa, and is suitable for traditional Chinese medicine health care, family health care, and professional moxa therapy scenes, and is used no more than 3 times a week (except for people with moderate constitution).

9. The customized nine-constitution pharmacomoxibustion stick according to claim 8, wherein the customized nine-constitution pharmacomoxibustion stick is prepared by mixing the nine-constitution pharmacomoxibustion sticks of claim 8. Different moxa therapy methods are set for different constitutions: people with yang deficiency, qi deficiency, and phlegm-dampness constitution use gentle moxibustion (moxibustion distance from skin 3-5 cm); people with yin deficiency and damp-heat constitution use pecking moxibustion (moxibustion distance from skin 5-7 cm).

10. The customized nine-constitution pharmacomugwort stick according to claim 8, wherein the customized nine-constitution pharmacomugwort stick is prepared by mixing the nine-constitution pharmacomugwort sticks of claim 8 in a ratio of 1:1:1:1:1:1:1:1:

1. The outer packaging of the moxa stick is provided with clear constitution identification color blocks: red for yang deficiency constitution, blue for yin deficiency constitution, yellow for qi deficiency constitution, brown for phlegm-dampness constitution, green for damp-heat constitution, purple for blood stasis constitution, orange for qi depression constitution, gray for special constitution, and white for moderate constitution, to facilitate users to quickly identify and adapt to their constitution.

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