Liquid UV filter compositions containing glycols
By using a combination of liquid UV filter and diol, the safety hazards of powdered UV filter and the production complexity of high-viscosity liquid UV filter are solved, achieving a broad-spectrum UV protection effect with low energy consumption and low cost.
Patent Information
- Application Number
- CN202580002970.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2024-02-23
- Filing Date
- 2025-02-23
- Publication Date
- 2026-01-06
AI Technical Summary
Existing sunscreen compositions using powdered UV filters pose safety hazards, are difficult to handle, and consume a lot of energy. Liquid UV filter mixtures have high viscosity, which complicates production and increases costs.
A UV filter concentrate containing at least one liquid UV filter, two crystalline oil-soluble UV filters, and a small amount of glycol is incorporated into a sunscreen composition through a cold-to-cold or cold-to-hot manufacturing process to reduce viscosity and ensure uniform distribution.
It achieves safe, low-cost, and low-energy-consumption broad-spectrum UV protection, ensuring uniform distribution and consistent protection of UV filters in sunscreen compositions, and reducing production risks and equipment maintenance costs.
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Abstract
Description
Technical Field
[0001] This invention relates to a UV filter concentrate comprising at least one oil-soluble organic UV filter UV1 that is liquid at room temperature, and at least two different oil-soluble organic UV filters UV2 and UV3 that are crystalline at room temperature, as well as at least one diol. The UV filter concentrate is processed into a sunscreen composition, a cosmetic composition, or a home care composition. Background Technology
[0002] The negative effects of exposure to UV light are well-known. Prolonged sun exposure can cause skin damage such as sunspots and make hair dry and brittle. When the skin is exposed to UV light with wavelengths between 290 nm and 400 nm, long-term damage can lead to serious conditions such as skin cancer; the type of damage depends on the wavelength of the radiation.
[0003] UV radiation also contributes to aging by causing the formation of free radicals in the skin. Free radicals include, for example, singlet oxygen, hydroxyl radicals, superoxide anions, nitric oxide, and hydrogen radicals. These free radicals attack DNA, membrane lipids, and proteins, producing carbon radicals. These then react with oxygen to produce peroxide radicals, which can attack adjacent fatty acids to generate new carbon radicals. This cascade leads to a chain reaction that produces lipid peroxidation products. Damage to cell membranes results in decreased cell permeability, increased intracellular ion concentration, and a reduced ability to excrete or detoxify waste products. The end result is a loss of skin elasticity and the appearance of wrinkles. This process is often referred to as photoaging.
[0004] In addition, UVA radiation can trigger phototoxic or photosensitive skin reactions.
[0005] UV rays are classified according to their wavelength as UVA rays (320nm to 400nm) or UVB rays (280nm to 320nm).
[0006] To mitigate these negative effects of UV radiation, i.e. to protect the skin and keratin materials from UV radiation, sunscreen compositions are typically used. These sunscreen compositions contain shielding agents that are active in both the UVA and UVB ranges (i.e., the full range from 280 nm to 400 nm).
[0007] UV filters are compounds that have a significant ability to absorb ultraviolet radiation. They are used in sunscreen compositions, cosmetics, dermatological and pharmacological compositions, or sunscreen compositions, but also to improve the light-resistance of industrial compositions such as paints, varnishes, plastics, textiles, polymers (such as polymers and copolymers of monoolefins and dienes, polystyrene, polyurethane, polyamide, polyester, polyurea, and polycarbonate), encapsulation materials, and rubbers.
[0008] Organic and inorganic UV filters are classified into UVA filters and UVB filters based on the location of their maximum absorption. If a UV filter absorbs both UVA and UVB, it is called a UVA / B broadband absorber or a UVA / UVB broadband filter.
[0009] To achieve the desired maximum level of UV radiation protection, sunscreen compositions or cosmetics, especially dermatological and pharmacological compositions, are formulated as mixtures containing UV filters of varying concentrations, and the choice of UV filters used is determined by national or regional regulations. For example, UV filters that can be used to protect the skin are regulated in the USA by the US FDA through its OTC monograph system, and in the EU by the Cosmetic Regulations. Regulations covering the use of UV filters also exist in other countries and regions. These regulations not only specify the filters that can be used but also determine the maximum level of use for each UV filter. Therefore, the number of UV filters available to achieve high efficacy in terms of SPF and UVA protection is limited.
[0010] The production of sunscreen compositions typically involves a cold-to-cold manufacturing process, a cold-to-hot manufacturing process, or a hot-to-hot manufacturing process.
[0011] In a cold-in-cold manufacturing process, all ingredients are mixed at room temperature, which is energy-efficient but may limit the use of certain components, such as crystalline components. A cold-in-hot manufacturing process involves heating some ingredients to enhance their solubility and then cooling them before incorporating them into the cold phase. This method can improve the stability and homogeneity of the sunscreen composition, but requires more energy due to the heating step. A hot-in-hot manufacturing process involves heating the aqueous and oil phases separately. When both phases reach the desired temperature, they are combined—this is the "hot-in-hot" step. This step is critical, and the mixing needs to be thorough to ensure proper homogenization.
[0012] Specifically, in either a cold-to-heat or hot-to-heat manufacturing process, certain components with high melting points, such as waxes, certain UV filters, or lipid components, are heated. This heating enhances their solubility and allows for a more uniform distribution in the final sunscreen composition. After heating, these components are cooled to seamlessly integrate into a cold phase, which typically contains water-based ingredients and other components stable at room temperature. This method ensures a stable emulsion, thereby optimizing the efficacy and consistency of the sunscreen composition.
[0013] To achieve the desired SPF and UVA protection, a combination of at least two UV filters (one UVB filter and one UVA filter) is necessary. Especially for high SPF with adequate UVA protection, a combination of several UV filters is required, some of which may be in powder form. First, powdered UV filters can pose safety hazards and health risks due to the possibility of inhalation or eye contact. Second, powder form can present handling difficulties, such as problems with uniform mixing and dissolution, which can affect the consistency and efficacy of the sunscreen composition. Additionally, powder can be messy and inconvenient to handle, complicating the manufacturing process.
[0014] Furthermore, manufacturing sunscreen compositions using powdered UV filters can be more energy-intensive than using liquid UV filters. Powdered UV filters require additional steps for safe and efficient handling, such as protective equipment and specialized mixing processes to ensure homogeneity. In contrast, liquid UV filter mixtures simplify the manufacturing process, reducing labor, time, and energy expenditures. This efficiency translates into cost savings and potentially safer, more streamlined production workflows.
[0015] Processing UV filters in powder form is energy inefficient for several reasons. First, it typically requires additional mechanical processes to ensure proper mixing and heating for proper dissolution, which consumes more energy. Furthermore, the necessary safety measures, such as ventilation systems to prevent inhalation risks, increase overall energy usage. In contrast, liquid mixtures are generally easier to handle and integrate into sunscreen compositions, resulting in lower energy consumption during the manufacturing process.
[0016] However, the use of high-viscosity liquid UV filter mixtures in the production of sunscreen products, particularly during the mixing process, still presents several disadvantages. Higher viscosity mixtures are more challenging to pump and agitate, requiring more energy and time, which significantly increases production costs. The additional energy required for agitation and pumping not only increases operating costs but also applies more strain to equipment, potentially leading to more frequent maintenance and shorter mechanical lifespan. This increased strain also raises the risk of mechanical failure, creating safety issues in the production environment. Furthermore, the difficulty in handling and mixing high-viscosity mixtures can result in uneven blending of sunscreen components, potentially affecting the quality and efficacy of the final product. In summary, the high viscosity of liquid UV filter mixtures complicates the production process, increases costs, and poses safety hazards in the manufacture of sunscreen products.
[0017] Therefore, there is a need to provide liquid UV filter compositions with relatively low viscosity that provide UVB and UVA protection and can be easily and safely incorporated into a wide range of sunscreen compositions.
[0018] Therefore, one object of the present invention is to overcome the shortcomings of the prior art and to provide a liquid UV filter mixture with relatively low viscosity, which can be easily and safely incorporated into a sunscreen composition to obtain a sunscreen composition with broad-spectrum sun protection factors through a cold-to-cold manufacturing process, a cold-to-hot manufacturing process, or a hot-to-hot manufacturing process. This object is very challenging because any component that significantly reduces the viscosity of the UV filter mixture should not impair the other beneficial effects of the UV filter mixture.
[0019] Surprisingly, it has been found that a liquid UV filter composition comprising at least one liquid UV filter at room temperature, at least two different oil-soluble organic UV filters that are crystalline at room temperature, and at least one oil can be readily and safely incorporated into a sunscreen composition via a cold-to-cold manufacturing process, a cold-to-hot manufacturing process, or a hot-to-hot manufacturing process to obtain a sunscreen composition with broad-spectrum sun protection factors. Furthermore, it has been found that adding a small amount of diol, for example, based on the total weight of the UV filter concentrate in the range of ≥1.0 wt% to ≤6.0 wt%, results in a significant reduction in the viscosity of the UV filter concentrate.
[0020] This problem is addressed by the subject matter of the independent patent claims. However, other aspects of the invention will also become apparent from the wording of the dependent patent claims, in conjunction with the following detailed description of the accompanying embodiments and drawings. Summary of the Invention
[0021] Therefore, in a first aspect, the present invention relates to a UV filter concentrate that is a liquid at room temperature, comprising... (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b) At least two different oil-soluble organic UV filters, UV2 and UV3, comprising ≥40% by weight to ≤97% by weight, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤135°C, preferably 130°C. (c) at least one diol, ranging from ≥0.1% by weight to ≤6.0% by weight; The weight percentage is based on the total weight of the UV filter concentrate.
[0022] This invention is associated with at least one of the following advantages: • The use of the liquid UV filter concentrate of the present invention in the method of preparing sunscreen compositions reduces safety hazards.
[0023] The use of the liquid UV filter concentrate of the present invention in a method for preparing a sunscreen composition improves the process by minimizing additional steps for safe and effective handling, such as protective equipment and specialized mixing methods to ensure homogeneity.
[0024] • The method of this invention translates into cost savings and potentially safer, more streamlined production workflows.
[0025] • The liquid UV filter concentrate of the present invention can be processed into sunscreen compositions with broad-spectrum SPF, particularly by increasing the concentration of active ingredients to provide enhanced sun protection factors.
[0026] • Liquid UV filters are mixed more evenly within the formulation, thereby ensuring uniform distribution and consistent protection of the UV filter in the final product.
[0027] • Any equipment used to manufacture the liquid UV filter concentrate of the present invention is easier to clean than that used to prepare the same UV filter concentrate without diol.
[0028] • The diol in the UV filter concentrate of the present invention reduces the viscosity of the concentrate and also exhibits antimicrobial properties.
[0029] The primary application of the liquid UV filter concentrates of this invention is incorporation into sunscreen compositions. However, their advantageous properties during manufacturing also make them suitable for other cosmetic, personal care, and home care products requiring lower UV filter concentrations. In these applications as well, the liquid UV filter concentrates of this invention improve manufacturing efficiency, ensure a safer production process, minimize material costs, and further reduce handling and exposure risks for production personnel. Detailed Implementation
[0030] In the context of this invention, the following general meanings apply: The terms “comprising,” “including,” and “containing” should be understood as open-ended terms, and mean that the components mentioned after the terms are necessary but not “limited”, and that other components may be added and are still covered by the present invention.
[0031] The term "composed of" as used in this invention means that, based on the total weight of the sunscreen composition or cosmetic composition or cosmetic composition, the total amount of components (a) and (b) adds up to 100% by weight, and indicates that the subject matter is closed and may include only explicitly stated limitations.
[0032] Unless the context otherwise indicates otherwise, whenever “contains” is mentioned, it is intended to cover two alternative meanings: that is, “containing” or “consisting of”.
[0033] The term "at least one...compound" means that the sunscreen composition or cosmetic composition according to the invention may include any one of the individual compounds described subsequently or a mixture of two, three, four, five, six or even more different compounds described subsequently.
[0034] The term “optionally” means that the compound described below may, but not necessarily, be present in the composition, and the description includes embodiments in which the compound is included or embodiments in which the compound is not present.
[0035] In the context of this invention, a "sunscreen composition," also known as a sunscreen cream, sunscreen lotion, or sunscreen wash, is a photoprotective topical composition for use on the skin, comprising a UV-filtering compound that absorbs or reflects some of the sun's ultraviolet (UV) radiation, and thus helps prevent sunburn and, most importantly, skin cancer. Sunscreens come in the form of lotions, sprays, gels, foams (such as expanding foam lotions or stirring lotions), sticks, powders, and other topical compositions. UV-absorbing compounds are used not only in sunscreens but also in other personal care compositions, such as lipsticks, shampoos, hairsprays, bath products, soaps, and insect repellents. Personal care products are consumer products designed to cleanse, protect, or enhance the appearance of the body, including the skin, hair, mouth, and intimate areas. These products are commonly used for hygiene, grooming, and body care and may provide functional or aesthetic benefits.
[0036] In the context of this invention, the term "cosmetic composition" is a composition for cosmetic purposes containing a UV absorber to protect skin or hair from UV radiation. In addition to providing photoprotection, cosmetic compositions according to the invention are used to provide skin with beneficial anti-aging effects, whiten or prevent skin darkening, improve skin appearance, reduce visible signs of skin aging, and improve skin radiance and firmness.
[0037] In the context of this invention, the term "home care composition" refers to essential household items used for daily care and cleaning purposes. They are used to maintain hygiene and a pleasant atmosphere in the home. Home care products typically include laundry detergents (powder, liquid, and tablets), fabric conditioners, dishwashing detergents (liquid and tablets), hard floor and surface cleaners, glass cleaners, carpet cleaners, oven cleaners, air fresheners, disinfectants, stain removers, and car wash products. These products are typically manufactured in liquid, powder, spray, granule, or other forms. Such formulations containing sunscreens prevent premature light damage and photobleaching to surfaces and the home care formulation itself.
[0038] The terms “or” or “and / or” are used as function words to indicate that two words or phrases will be used together or separately.
[0039] The endpoints of all ranges for the same component or property are included, and they can be combined independently.
[0040] In one aspect, the present invention relates to a UV filter concentrate that is liquid at room temperature, comprising... (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b) At least two different oil-soluble organic UV filters, UV2 and UV3, comprising ≥40% by weight to ≤97% by weight, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤135°C, preferably 130°C. (c) at least one diol, ranging from ≥0.1% by weight to ≤6.0% by weight; The weight percentage is based on the total weight of the UV filter concentrate.
[0041] Preferably, based on the total weight of the UV filter concentrate of the present invention, the UV filter concentrate contains at least two different oil-soluble organic UV filters, UV2 and UV3, in an amount ranging from ≥50% to ≤88% by weight, more preferably from ≥60% to ≤85% by weight, and even more preferably from ≥70% to ≤85% by weight.
[0042] In the context of this invention, the term "UV filter concentrate" refers to a highly concentrated UV filter formulation designed for incorporation into sunscreen compositions. The UV filter concentrate of this invention can be seamlessly incorporated into a variety of different sunscreen compositions having broad-spectrum SPF and other properties such as water resistance, a pleasant skin feel, and compatibility with other beneficial skincare ingredients.
[0043] Preferably, the UV filter concentrate of the present invention has a viscosity, as measured by Brookfield DV-III with a rotor CP51 at 2.0 rpm, in the range of ≥2000 mPa·s to ≤24000 mPa·s at 20°C, more preferably in the range of ≥8000 mPa·s to ≤20000 mPa·s at 20°C, and even more preferably in the range of ≥10000 mPa·s to ≤20000 mPa·s at 20°C.
[0044] Preferably, the UV filter concentrate of the present invention has a viscosity, as measured by Brookfield DV-III with a rotor CP51 at 2.0 rpm, in the range of ≥3000 mPa.s to ≤10000 mPa.s at 30°C, more preferably in the range of ≥4000 mPa.s to ≤8000 mPa.s at 30°C.
[0045] When these liquids are transported through pipelines, the viscosity of the liquid is crucial in industrial and manufacturing processes. When the viscosity is too high, i.e., the liquid is too thick, energy is required to pump the liquid through the pipeline, resulting in higher operating costs. Furthermore, strain is applied to the pump system and associated infrastructure, increasing wear on the pipeline system. The viscosity of the UV filter concentrate of this invention allows for easy flow through the pipeline without causing undue strain on the pumping system.
[0046] Preferably, at least one oil-soluble organic UV filter UV1, which is liquid at room temperature, is selected from the group consisting of: humosafil, octyl cyanobenzyl acrylate, 2-ethylhexyl methoxycinnamate, 2-ethylhexyl salicylate, polyacrylamide methyl benzyl camphor, menthyl anthranilate, dimethyl PABA 2-ethylhexyl ester, TEA-salicylate, polysiloxane-15, and isoamyl p-methoxycinnamate. More preferably, at least one oil-soluble organic UV filter UV1, which is liquid at room temperature, is selected from the group consisting of: 2-ethylhexyl methoxycinnamate, 2-ethylhexyl salicylate, and isoamyl p-methoxycinnamate.
[0047] Preferably, based on the total weight of the UV filter concentrate, at least one oil-soluble organic UV filter UV1 is present in an amount ranging from ≥5% to ≤60% by weight, more preferably from ≥10% to ≤50% by weight, even more preferably from ≥12% to ≤40% by weight, and most preferably from ≥15% to ≤30% by weight.
[0048] At least one oil-soluble organic UV filter, UV1, can be partially replaced by at least one oil (d), provided that the overall sun protection activity of the formulation is maintained. This allows for greater formulation flexibility while preserving the efficacy of UV protection. At least one oil (d) can help improve spreadability, sensory properties, and emollient properties without compromising the stability or photoprotective function of the composition.
[0049] The selection and concentration of at least one oil (d) should be carefully optimized to ensure that the sun protection factor (SPF) and UVA absorption properties remain within the desired range, thereby maintaining the high-performance properties of the liquid UV filter concentrate of the present invention. At least one oil-soluble organic UV filter UV1, initially present in an amount of ≥5% to ≤60% by weight (preferably ≥10% to ≤50% by weight, more preferably ≥12% to ≤40% by weight, most preferably ≥15% to ≤30% by weight), can be partially replaced by at least one oil (d) in an amount of ≥10% to ≤50% by weight, preferably ≥20% to ≤45% by weight, while ensuring that the UV protection activity remains effective.
[0050] Preferably, at least two different oil-soluble organic UV filters, UV2 and UV3, are selected from the group consisting of: diethylhexylbutamidotriazinone, benzophenone-3, cresoltrazol trisiloxane, 4-methylbenzyl camphor, diethylaminohydroxybenzoylhexyl benzoate, benzophenone-8, butylmethoxydibenzoylmethane, diethylhexyloxyphenol methoxyphenyltriazine, methoxypropylaminocyclohexeneide ethoxyethyl cyanoacetate, and ethylhexylethylhexyltriazinone.
[0051] Preferably, the organic oil-soluble UV filter UV2 comprises at least one organic UV filter UV2a and at least one organic UV filter UV2b, wherein the organic oil-soluble UV filter UV2a has a melting point MP2a in the range of ≥30°C to ≤70°C, and the organic oil-soluble UV filter UV2b has a melting point MP2b in the range of ≥71°C to ≤100°C.
[0052] Preferably, at least one organic UV filter UV2a is selected from the group consisting of: benzophenone-3,4-methylbenzyl camphor, diethylaminohydroxybenzoyl benzoate and benzophenone-8, more preferably at least one organic UV filter UV2a is diethylaminohydroxybenzoyl benzoate.
[0053] Preferably, at least one organic UV filter UV2b is selected from the group consisting of: butyl methoxydibenzoylmethane, diethylhexylbutamidotriazine, bis(ethylhexyloxyphenol)methoxyphenyltriazine, cresoltrazol trisiloxane, and methoxypropylaminocyclohexeneylethoxyethyl cyanoacetate; more preferably, at least one organic UV filter UV2b is bis(ethylhexyloxyphenol)methoxyphenyltriazine.
[0054] Preferably, the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥101°C to ≤135°C, preferably 130°C.
[0055] Preferably, the organic oil-soluble UV filter UV3 is ethylhexyltriazine ketone.
[0056] Preferably, the ratio of the sum of the weight percentages of at least two different oil-soluble organic UV filters, UV2 and UV3, to the weight percentage of at least one oil-soluble organic UV filter, UV1, is in the range of ≥3.0:1.0 to ≤20.0:1.0, more preferably in the range of ≥4.0:1.0 to ≤7.0:1.0, wherein the weight percentages are based on the total weight of the UV filter concentrate.
[0057] Preferably, at least one diol (c) is an unsubstituted alkanediol having a straight or branched chain with 5 to 12 carbon atoms, more preferably an unsubstituted ortho-alkanediol having a straight or branched chain with 5 to 12 carbon atoms, and even more preferably an unsubstituted ortho-alkanediol having a straight or branched chain with 6 to 10 carbon atoms. Even more preferably, the unsubstituted ortho-alkanediol having a straight or branched chain with 5 to 12 carbon atoms is selected from the group consisting of: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and 2,3-dodecanediol.
[0058] In the field of cosmetic ingredients, ortho-alkanediols with 6 to 12 carbon atoms, such as 1,2-hexanediol, 1,2-heptanediol, and 1,2-octanediol, are of considerable importance. These compounds can be derived from both fossil fuels and bio-based materials, with bio-based variants being marketed under the name Hydrolite due to their environmental, social, and governance (ESG) benefits. ® Green is gaining popularity. The ESG advantages of bio-based alkyl glycols are substantial, primarily due to their lower carbon footprint and utilization of renewable resources, aligning with global sustainability goals. This approach provides a more environmentally friendly alternative to their fossil fuel-derived equivalents, thus making a positive contribution to environmental protection.
[0059] Bio-based synthesis of these alkyldiols (including 1,2-hexanediol and 1,2-heptanediol) typically involves the fermentation of plant-derived sugars. This method employs specialized microorganisms that convert these sugars into the target alkyldiol via enzymatic reactions. For 1,2-hexanediol, synthesis may involve the hydrogenation of the derived dicarboxylic acid, while a similar route can be used for 1,2-heptanediol, albeit with different precursor molecules. The synthesis of 1,2-octanediol follows a comparable route, utilizing plant sugars as starting materials. These bio-based production methods not only reduce dependence on non-renewable resources but also reduce the generation of harmful byproducts, aligning with green chemistry principles. Furthermore, using agricultural raw materials for synthesis supports rural economies and promotes a circular economy. The shift towards bio-based production of compounds such as 1,2-hexanediol, 1,2-heptanediol, and 1,2-octanediol is an important step towards more sustainable and reliable manufacturing in the cosmetics industry.
[0060] 1,2-Hexanediol is frequently used in cosmetics due to its ability to inhibit microbial growth, thereby extending product shelf life and maintaining its safety and integrity. It is valued not only for its preservative properties but also for its non-irritating and non-allergenic nature. Similarly, 1,2-Octanediol also exhibits antimicrobial properties and is used as a preservative in personal care products. Its effectiveness against bacteria and fungi, combined with its low toxicity and good compatibility with other cosmetic ingredients, makes it a suitable choice for a wide range of formulations.
[0061] Preferably, based on the total weight of the UV filter concentrate, at least one diol (c) is present in an amount ranging from ≥0.5% by weight to ≤6.0% by weight, more preferably from ≥1.0% by weight to ≤6.0% by weight, and even more preferably from ≥1.5% by weight to ≤6.0% by weight.
[0062] Preferably, the UV filter concentrate of the present invention further comprises at least one oil (d). More preferably, the at least one oil (d) is selected from the group consisting of: Guerbert alcohol based on a fatty alcohol having 6 to 18 carbon atoms, straight-chain C6-C 22 - Fatty acids and straight-chain or branched C6-C 22 -Ester or branched C6-C fatty alcohols 13 -Carboxylic acids with straight-chain or branched C6-C 22 -Ester of fatty alcohols, straight-chain C6-C 22 -Esters of fatty acids and branched alcohols, straight-chain or branched C2-C 10 Diols with straight-chain or branched C6-C 22 - Fatty acid esters, C 18 -C 38 -alkyl hydroxycarboxylic acids with straight-chain or branched C6-C 22- Esters of fatty alcohols and / or C2-C5 alcohols, esters of straight-chain or branched fatty acids with polyols and / or gerbert alcohols, based on C6-C 10 - Triglycerides of fatty acids, based on C6-C 18 - A liquid mixture of monoglycerides / diglycerides / triglycerides of fatty acids, C6-C 22 - Esters of fatty alcohols and / or gerberis alcohols with aromatic carboxylic acids, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, straight-chain and branched C6-C... 22 - Fatty alcohol carbonates, based on guerbert carbonates of fatty alcohols having 6 to 18 carbon atoms, benzoic acid with straight-chain and / or branched C6-C... 22 -Esters of alcohols, straight-chain or branched, symmetrical or asymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group, ring-opening products of epoxidized fatty acid esters with polyols, aliphatic hydrocarbons or cycloalkanes, ring-opening products of fatty acid esters with polyols, aliphatic hydrocarbons or cycloalkanes, by addition of 2 mol to 30 mol of ethylene oxide and / or 0 mol to 5 mol of propylene oxide to a straight-chain C8- 22 Addition to C4 of fatty alcohols 12 - 22 The C-values of products added to fatty acids and to alkylphenols containing 8 to 15 carbon atoms in the alkyl group, and the C-values of addition products of 1 to 30 mol of ethylene oxide to glycerol. 12 / 18 Fatty acid monoesters and diesters, glycerol monoesters, diesters and triesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms, as well as dehydrated sorbitol monoesters and diesters and their ethylene oxide addition products, addition products of 15 mol to 60 mol of ethylene oxide to castor oil and / or hydrogenated castor oil, addition products of 2 mol to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil, petrolatum, squalane, squalene, isohexadecane, dialkylcyclohexane, based on straight-chain, branched, unsaturated or saturated C 6 / 22 Esters and metaesters of fatty acids, ricinoleic acid and 12-hydroxystearic acid, and dialkyl ethers of glycerol, polyglycerol, pentaerythritol, dipentaerythritol and isosorbide.
[0063] Even more preferably, at least one oil (d) is selected from the group consisting of: linear or branched C2-C 10 Diols with straight-chain or branched C6-C 22 - Fatty acid esters, C 18 -C 38 -alkyl hydroxycarboxylic acids with straight-chain or branched C6-C 22- Esters of fatty alcohols and / or C2-C5 alcohols, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; benzoic acid and straight-chain and / or branched C6-C... 22 - Esters of alcohols, and fatty acid esters of polyols, aliphatic hydrocarbons, or cycloalkanes, based on straight-chain, branched-chain, unsaturated, or saturated C464. 6 / 22 The oil contains monoglycerides, diglycerides, and triglycerides of fatty acids, ricinoleic acid, and 12-hydroxystearic acid, as well as metaesters, and glycerol, polyglycerol, pentaerythritol, and dipentaerythritol. Most preferably, at least one oil (d) is selected from the group consisting of ethylhexyl acetoxystearate, propylene glycol dioctanoate, propylene glycol octanoate, diethylhexyl 2,6-naphthalenedicarboxylate, diisopropyl adipate, and caprylic / decanoic acid triglycerides.
[0064] Preferably, at least one oil (d) is a fatty acid ester selected from the group consisting of: C 12 -C 15 Alkyl benzoate, Caprylic / Capric triglyceride, Caprylic / Capric / Lauryl triglyceride, Caprylic / Capric / Linoleic triglyceride, Caprylic / Capric / Myristic acid / Stearic triglyceride, Caprylic / Capric / Palmitic acid / Stearic triglyceride, Caprylic / Capric / Stearic triglyceride, Caprylic / Capric / Succinic triglyceride, Caprylic octyl acetate, Cetearyl ethylhexanoate, Cetearyl isononanoate, Cetearyl nonanoate, Cococaprylic caprylate, Cococaprylic caprylate Coconut caprylate / caprylate, decyl cocoate, decyl oleate, dicaprylyl carbonate, diethyl succinate, diethylhexyl 2,6-naphthalenedicarboxylate, diethylhexyl carbonate, dibutyl adipate, diisopropyl adipate, dipropylheptyl carbonate, ethyl laurate, ethylhexyl isononanoate, ethylhexyl palmitate, ethylhexyl stearate, ethylhexyl acetoxystearate, caprylic / capric glyceride, caprylic / capric glyceride, glyceryl laurate, triacetylhydroxystearic acid Glycerides, Triacetyl Ricinoleate, Hexyl Laurate, Isoamyl Acetate, Isoamyl Cocoate, Isopropyl Palmitate, Isosorbide Dicaprylate, Isopropyl Myristate, Myristyl Myristate, Oleic / Linoleic Triglycerides, Oleic / Palmyl Triglycerides, Oleic / Palmyl / Lauryl / Myristic / Linoleic Triglycerides, Propylene Glycol Caprylate, Ricinoleic / Hexanoic / Capric / Capric Triglycerides, Stearyl Alder, Erucic Acid, Palmitic Acid / Triglyceride stearate, propylene glycol dicaprylate, propyl heptyl caprylate, stearate heptate / stearate caprylate, triheptanoate, trihydroxystearin, triisononenin, triisopalmitin, glyceryl triisostearate, trilaurate, trilinoleic acid trioleate, trilinolein, trilinolinoleic acid trimyridine, trioleic acid trioleate, tripalmitin, trinonanoate, triricinoleic acid tricarboxylate, and tristearate, as well as dimethyl isosorbide.
[0065] Preferably, at least one oil (d) is selected from the group consisting of ether-based emollients, and more preferably from the group consisting of: dioctyl ether, decyl ether, C12-15 alkyl ether, polydimethylsiloxane copolyol ether and cetearyl ethylhexanoate.
[0066] Preferably, at least one oil (d) is selected from the group consisting of hydrocarbon emollients, and more preferably from the group consisting of: undecane, tridecane, dodecane, isohexadecane, isododecane, isoeicosane, squalane, hydrogenated polyisobutylene, and polydecene.
[0067] In a preferred embodiment, at least one oil (d) is a diester of 1,3-propanediol and a straight-chain C6-C22 fatty acid, preferably selected from the group consisting of: propylene glycol dioctanoate / propylene glycol decanoate, propylene glycol didecanoate, propylene glycol dioctanoate, propylene glycol dilaurate, and propylene glycol distearate, more preferably at least one oil (d) is propylene glycol dioctanoate / propylene glycol decanoate.
[0068] Preferably, based on the total weight of the UV filter concentrate, at least one oil (d) is present in an amount ranging from ≥10.0% by weight to ≤50% by weight, more preferably from ≥20% by weight to ≤45% by weight.
[0069] Preferably, the UV filter concentrate of the present invention does not contain any oil-soluble organic UV filter in its crystalline form. Preferably, the UV filter concentrate of the present invention remains liquid at room temperature and does not show any crystals for at least 3 months, more preferably at least 6 months, or even more preferably at least 12 months, preferably when the UV filter concentrate is stored in a sealed container.
[0070] Preferably, the UV filter concentrate of the present invention further comprises at least one additional UV filter selected from the group consisting of: 2-ethylhexyl salicylate, ethylhexyl triazine, butyl methoxydibenzoylmethane, terephthalimide diborneol sulfonic acid and its salt, 2-(4-diethylamino-2-hydroxybenzoyl)benzoate hexyl ester, menthyl anthranilate, 2,2'-(1,4-phenylene)bis-[1H-benzoyl] [Imidazole-4,5-disulfonic acid] disodium salt, methoxypropylaminocyclohexeneylidene ethoxyethyl cyanoacetate, octyl cyanadieneacrylate, homosalate, octyl salicylate, 2-ethylhexyl p-dimethylaminobenzoate, triethanolamine salicylate, 2-ethylhexyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-phenylbenzimidazole sulfonic acid and its salts, 3-(4'-methylbenzylene)-d,l-camphor, 4,4'-[(6-[4-(1,1-dimethyl...]] [(aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]bis(2-ethylhexyl benzoate), benzyl malonic acid ester-polysiloxane, 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate tri(2-ethylhexyl) ester, bis(ethylhexyl)oxyphenol methoxyphenyltriazine, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, 2-hydroxy-4-methoxybenzophenone, phenol, -(2H-benzotriazol-2-yl-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyl)propyl), 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)phenol, tri-biphenyltriazine, and 5,6,5',6'-tetraphenyl-3,3'-(1,4-phenylene)bis(1,2,4-triazine). After manufacturing the liquid UV filter concentrate of the present invention, additional UV filter agents are incorporated into the UV filter concentrate. This step allows for greater formulation flexibility, enabling the adjustment of UV protection levels as needed while maintaining the excellent processing and handling benefits of the concentrate.
[0071] In a preferred embodiment, based on the total weight of the UV filter concentrate of the present invention, the UV filter concentrate contains at least one alkyl cellulose, preferably ethyl cellulose, in an amount ranging from ≥0.01 wt% to ≤1.0 wt%, more preferably from ≥0.02 wt% to ≤0.5 wt%, and even more preferably from ≥0.02 wt% to ≤0.3 wt%. It has been found that at least one alkyl cellulose effectively prevents UV filter crystallization, allowing the UV filter concentrate containing at least one alkyl cellulose to be stored for more than 12 months or even longer.
[0072] Alkyl cellulose, and particularly ethyl cellulose, is a derivative of cellulose in which one or more hydroxyl groups on glucose monomers of the cellulose backbone are alkylated. Ethyl cellulose is characterized by its degree of substitution (DS), which refers to the average number of hydroxyl groups substituted by ethyl groups for each glucose unit. The DS of ethyl cellulose used in this application is typically from 1.0 to 3.0, indicating that each glucose monomer can be substituted by one to three ethyl groups. In a preferred embodiment, the weight-average molecular weight of the ethyl cellulose is in the range of ≥10,000 g / mol to ≤300,000 g / mol. In a preferred embodiment, the ethyl cellulose can be derived from both natural and fossil-based sources. Preferably, the ethyl cellulose is derived from natural sources. Natural sources include purified cellulose obtained from cotton or wood pulp, which is then chemically modified to introduce ethyl groups. Suppliers of industrial ethyl cellulose include, but are not limited to, companies such as Dow Chemical Company, Sigma-Aldrich, and Ashland Inc. (Antaron). ™ Eco) company.
[0073] In a preferred embodiment, at least one alkyl cellulose, preferably ethyl cellulose, is added in step (A).
[0074] In a preferred embodiment, the UV filter concentrate contains (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b1) At least one organic oil-soluble UV filter UV2a, having a melting point MP2a in the range of ≥30°C to ≤70°C. (b2) At least one organic oil-soluble UV filter, UV2b, having a melting point MP2b in the range of ≥71°C to ≤100°C. (b3) At least one organic oil-soluble UV filter, UV3, having a melting point MP3 in the range of ≥101°C to ≤135°C, preferably 130°C. (c) at least one diol, ranging from ≥0.1% by weight to ≤6.0% by weight. At least three different oil-soluble organic UV filters, UV2a, UV2b and UV3, are present in amounts ranging from ≥40% by weight to ≤97% by weight.
[0075] In a preferred embodiment, the UV filter concentrate contains (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b1) At least one organic oil-soluble UV filter UV2a, having a melting point MP2a in the range of ≥30°C to ≤70°C. (b2) At least one organic oil-soluble UV filter, UV2b, having a melting point MP2b in the range of ≥71°C to ≤100°C. (b3) At least one organic oil-soluble UV filter, UV3, having a melting point MP3 in the range of ≥101°C to ≤135°C, preferably 130°C. (c) at least one diol, from ≥0.1% by weight to ≤6.0% by weight, and At least one alkyl cellulose, preferably ethyl cellulose, comprising ≥0.01% by weight to ≤1.0% by weight. At least three different oil-soluble organic UV filters, UV2a, UV2b and UV3, are present in amounts ranging from ≥40% by weight to ≤97% by weight.
[0076] In a preferred embodiment, component (a) is 2-ethylhexyl salicylate, component (b1) is diethylaminohydroxybenzoylhexyl benzoate, component (b2) is bisethylhexyloxyphenol methoxyphenyl triazine, and component (c) is ethylhexyl triazine ketone.
[0077] In a preferred embodiment, the UV filter concentrate, which is a liquid at room temperature, contains... (a) at least one oil-soluble organic UV filter UV1 that is liquid at room temperature, comprising ≥12% to ≤40% by weight. (b) At least two different oil-soluble organic UV filters, UV2 and UV3, comprising ≥40% by weight to ≤97% by weight, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤135°C, preferably 130°C. (c) at least one diol, ≥1.0% by weight to ≤6.0% by weight, selected from the group consisting of: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, ethylhexyl acetoxystearate, propylene glycol dioctanoate, propylene glycol octanoate, diethylhexyl 2,6-naphthalenedicarboxylate, diisopropyl adipate, and octanoic / decanoic triglycerides; Each weight percentage is based on the total weight of the UV filter concentrate.
[0078] In a preferred embodiment, the UV filter concentrate, which is a liquid at room temperature, comprises or consists of the following items. (a) At least one oil-soluble organic UV filter UV1, comprising ≥10% to ≤20% by weight, selected from the group consisting of: humosafil, octyl cyanadieneacrylate, 2-ethylhexyl methoxycinnamate, 2-ethylhexyl salicylate, polyacrylamide methylbenzyl camphor, menthyl anthranilate, dimethyl PABA 2-ethylhexyl, TEA-salicylate, polysiloxane-15, and isoamyl p-methoxycinnamate. (b1) At least one organic UV filter UV2a, ranging from ≥20% by weight to ≤45% by weight, selected from the group consisting of: benzophenone-3,4-methylbenzyl camphor, hexyl diethylaminohydroxybenzoyl benzoate and benzophenone-8, more preferably at least one organic UV filter UV2a is hexyl diethylaminohydroxybenzoyl benzoate.
[0079] (b2) At least one organic UV filter UV2b, comprising ≥20% by weight to ≤45% by weight, selected from the group consisting of: butyl methoxydibenzoylmethane, diethylhexylbutamidotriazine, bis(ethylhexyloxyphenol)methoxyphenyltriazine, cresoltrazol trisiloxane, and methoxypropylaminocyclohexeneylethoxyethyl cyanoacetate, more preferably at least one organic UV filter UV2b being bis(ethylhexyloxyphenol)methoxyphenyltriazine. (b3) ≥10.0% by weight to ≤30% by weight of ethylhexyltriazine, and (c) at least one diol, ≥1.0% by weight to ≤6.0% by weight, selected from the group consisting of: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, ethylhexyl acetoxystearate, propylene glycol dioctanoate, propylene glycol octanoate, diethylhexyl 2,6-naphthalenedicarboxylate, diisopropyl adipate, and octanoic / decanoic triglycerides; Each weight percentage is based on the total weight of the UV filter concentrate.
[0080] Preferably, a method for preparing a UV filter concentrate as described above includes at least the following steps: (A) Heating at least one oil-soluble organic UV filter UV1, which is liquid at room temperature, to a temperature T1 in the range of ≥40°C to ≤75°C to obtain a heated solution; (B) At a temperature T2 in the range of ≥50°C to ≤130°C, the heated solution of step (A) is mixed with at least two different oil-soluble organic UV filters, UV2 and UV3, to obtain a heated mixture, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤135°C, preferably 130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤135°C, preferably 130°C; (C) The heated mixture from step (B) is kept at temperature T3 to obtain a UV filter concentrate; During step (C), at least one diol (c) is added; and Temperature T3 is in the range of ≥20°C to ≤70°C lower than the highest melting point of at least two different oil-soluble organic UV filters, UV2 and UV3.
[0081] Preferably, the temperature T3 is ≥20°C to ≤50°C lower than the highest melting point of at least two different oil-soluble organic UV filters, UV2 and UV3, more preferably ≥20°C to ≤40°C lower. Preferably, the temperature T3 is in the range of ≥60°C to ≤110°C, and more preferably in the range of ≥80°C to ≤105°C.
[0082] Preferably, step (B) is performed within a time period ranging from ≥5 minutes to ≤24 hours, more preferably within a time period ranging from ≥10 minutes to ≤12 hours, even more preferably within a time period ranging from ≥30 minutes to ≤6 hours, and even more preferably within a time period ranging from ≥2 hours to ≤3 hours.
[0083] Preferably, step (B) includes the following steps: (B1) The heated solution from step (A) is mixed with at least one oil-soluble organic UV filter UV2a to obtain a heated mixture 1, wherein the oil-soluble organic UV filter has a melting point MP2a in the range of ≥30°C to ≤70°C. (B2) The heated mixture 1 from step (B1) is mixed with at least one oil-soluble organic UV filter UV2b to obtain a heated mixture 2, wherein the oil-soluble organic UV filter has a melting point MP2b in the range of ≥71°C to ≤100°C. (B3) The heated mixture 2 from step (B2) is mixed with at least one oil-soluble organic UV filter UV3 at a temperature T23 in the range of ≥80°C to ≤135°C, preferably 130°C, to obtain the heated mixture 3, wherein the oil-soluble organic UV filter has a melting point MP3 in the range of ≥101°C to ≤130°C.
[0084] Preferably, in step (B1), mixing is carried out at a temperature T21 in the range of ≥50°C to ≤95°C. Preferably, in step (B2), mixing is carried out at a temperature T22 in the range of ≥80°C to ≤100°C. Preferably, in step (B3), mixing is carried out at a temperature T23 in the range of ≥100°C to ≤135°C.
[0085] Preferably, steps (A), (B), and (C) are carried out in a mixer (such as a reservoir equipped with a stirrer) to obtain a homogeneous mixture of all components. The reservoir is preferably a container holding the components and can be of various shapes and sizes. The stirrer can be an agitator or mixing blade engineered to produce a homogeneous mixture by moving the components in the reservoir in a controlled manner. The design of the stirrer can be significantly varied and can be a simple paddle or a more complex structure characterized by multiple blades or specialized shapes to enhance mixing efficiency. The reservoir is preferably equipped with an integrated heating system, which can be an external jacket or an internal coil, thereby allowing for precise temperature control.
[0086] Preferably, step (C) is performed within a time period ranging from ≥1 hour to ≤24 hours, more preferably within a time period ranging from ≥1 hour to ≤5 hours, and even more preferably within a time period ranging from ≥1 hour to ≤3 hours.
[0087] Preferably, the method further includes the following step: (D) cooling the UV filter concentrate from step (C) to room temperature over a period of ≥30 minutes to ≤48 hours, preferably ≥30 minutes to ≤24 hours, more preferably ≥30 minutes to ≤12 hours, and even more preferably ≥30 minutes to ≤6 hours.
[0088] In one embodiment, the present invention relates to a sunscreen composition, cosmetic composition, or home care composition comprising at least one UV filter concentrate as described above or at least one UV filter concentrate obtained by the method described above. Therefore, the sunscreen composition, cosmetic composition, or home care composition of the present invention does indeed contain at least three UV filters.
[0089] Preferably, the sunscreen composition comprises at least one UV filter concentrate as described above or at least one UV filter concentrate obtained by the method described above, wherein the amount of the UV filter concentrate is in the range of ≥1.0 wt% to ≤35.0 wt% based on the total weight of the sunscreen composition or cosmetic composition, more preferably in the range of ≥5.0 wt% to ≤30.0 wt%, and even more preferably in the range of ≥10.0 wt% to ≤25.0 wt%.
[0090] Preferably, the sunscreen composition, cosmetic composition, or home care composition comprises one or more of the following: 2-ethylhexyl salicylate, diethylaminohydroxybenzoylhexyl benzoate, diethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazine ketone, and 1,2-octanediol. Most preferably, the sunscreen composition, cosmetic composition, or home care composition comprises all of the following: 2-ethylhexyl salicylate, diethylaminohydroxybenzoylhexyl benzoate, diethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazine ketone, and 1,2-octanediol.
[0091] In one embodiment, the present invention relates to a sunscreen composition, cosmetic composition, or home care composition comprising at least one UV filter concentrate as described above or at least one UV filter concentrate obtained by the method described above and at least one filter selected from the group consisting of: 2-ethylhexyl salicylate, ethylhexyl triazine, butyl methoxydibenzoylmethane, terephthalamide diborneol sulfonic acid and its salt, and 2-(4-diethylamino-2-hydroxybenzoyl). Hexyl benzoate, menthyl anthranilate, disodium 2,2'-(1,4-phenylene)bis-[1H-benzimidazole-4,5-disulfonic acid], methoxypropylaminocyclohexeneylethoxyethyl cyanoacetate, octyl cyanadieneacrylate, humosalilate, octyl salicylate, 2-ethylhexyl p-dimethylaminobenzoate, triethanolamine salicylate, 2-ethylhexyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-phenylbenzimidazole sulfonic acid and its salts, 3-(4'-methylbenzylene)-d, l-Camphor, 4,4'-[(6-[4-(1,1-dimethyl)aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]bis(2-ethylhexyl benzoate), benzyl malonate-polysiloxane, 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate tri(2-ethylhexyl) ester, bis(ethylhexyl)oxyphenol methoxyphenyltriazine, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, 2-hydroxy- 4-Methoxybenzophenone, phenol, 2-(2H-benzotriazol-2-yl-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyl)propyl, 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)phenol, tri-biphenyltriazine and 5,6,5',6'-tetraphenyl-3,3'-(1,4-phenylene)bis(1,2,4-triazine).
[0092] In this field, the use of UV filters to block radiation is well known. UV filters are compounds or mixtures of compounds that block or absorb ultraviolet (UV) light. UV classification includes UVA (320 nm to 400 nm), UVB (290 nm to 320 nm), and UVC (200 nm to 280 nm). UV-absorbing compounds are used not only in sunscreens but also in other personal care products such as lipsticks, shampoos, hairsprays, shower gels, soaps, and insect repellents. Chemical filters protect against UV radiation by absorbing, reflecting, or scattering it. Reflection and scattering are achieved through inorganic physical UV filters, such as titanium dioxide (TiO2) and zinc oxide (ZnO). Absorption, primarily of UVB, is accomplished through organic UV filters known as chemical UV filters.
[0093] In one embodiment, the sunscreen composition, cosmetic composition, or home care composition preferably comprises at least one inorganic UV filter. Preferred inorganic UV filters are titanium dioxide and zinc oxide, iron oxide, zirconium oxide, and cerium oxide.
[0094] According to the present invention, the at least one inorganic UV filter is preferably selected from the group consisting of: titanium dioxide (TiO2) (amorphous or crystalline in the form of rutile and / or anatase), zinc oxide (ZnO), iron oxide (Fe2O3), zirconium oxide (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium oxide (Ce2O3), barium carbonate (BaCO3), calcium carbonate (CaCO3), and mixtures thereof.
[0095] More preferably, the at least one inorganic UV filter is titanium dioxide, zinc oxide, or a mixture thereof; even more preferably, the at least one inorganic UV filter is titanium dioxide and / or zinc oxide; and most preferably, the at least one inorganic UV filter is zinc oxide. ZnO has a broad UVA / UVB absorption profile, while TiO2 provides better UVB protection.
[0096] According to another embodiment, the at least one inorganic UV filter has a median weight particle size d. 50 The particles are in the form of 1nm to 1000nm, preferably 3nm to 800nm, more preferably 5nm to 600nm, and most preferably 10nm to 400nm.
[0097] Inorganic UV filters also encompass nano-pigments of untreated or treated metal oxides (average size of primary particles: typically 1 nm to 100 nm, preferably 3 nm to 90 nm, more preferably 5 nm to 80 nm, and most preferably 10 nm to 70 nm), such as titanium dioxide (TiO2) (amorphous or crystalline in rutile and / or anatase form), zinc oxide (ZnO), iron oxide (Fe2O3), zirconium oxide (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium oxide (Ce2O3), barium carbonate (BaCO3), calcium carbonate (CaCO3), and mixtures thereof.
[0098] The treated nano-pigments and non-nano-pigments are pigments that have undergone one or more surface treatments with compounds that have chemical, electronic, mechanochemical, and / or mechanical properties, such as amino acids, beeswax, fatty acids, fatty acid esters, fatty alcohols, anionic surfactants, lecithin, sodium, potassium, zinc, iron, or aluminum salts of fatty acids, metal (titanium or aluminum) alkoxides, polyethylene, organosilicon, proteins (collagen or elastin), alkanolamines, silicon dioxide, metal oxides, sodium hexametaphosphate, aluminum oxide or glycerol, hydrated silica, stearic acid, jojoba ester, or glutamic acid derivatives.
[0099] The treated nano- and non-nano-pigments can be more specifically made of silica and alumina, alumina and aluminum stearate, alumina and aluminum laurate, iron oxide and iron stearate, silica, alumina and organosilicon, sodium hexametaphosphate, octyltrimethoxysilane, alumina and stearic acid, alumina and glycerol, or alumina and organosilicon or polyhydroxystearic acid, hydrated silica, jojoba ester, glutamic acid and derivatives. Other titanium dioxide nano-pigments treated with organosilicon are preferably TiO2 treated with octyltrimethylsilane, preferably having an average particle size of 25 nm to 40 nm; TiO2 treated with polydimethylsiloxane, preferably having an average particle size of 21 nm; or TiO2 treated with polydimethylhydrosiloxane, preferably having an average particle size of 25 nm.
[0100] Coated zinc oxide nano-pigments and non-nano-pigments include, for example, ZnO coated with polymethylhydrosiloxane; ZnO dispersions in cyclomethylsiloxane / oxyethyleneized polydimethylsiloxane containing 30% or 80% nano- or non-nano-zinc oxide coated with silica and polymethylhydrosiloxane; ZnO coated with perfluoroalkyl phosphates and copolymers based on perfluoroalkyl ethyls as dispersions in cyclopentane; ZnO coated with organosilicon-grafted acrylic polymers dispersed in cyclodimethylsiloxane; and ZnO coated with triethoxy... ZnO of octylsilane; ZnO coated with polyhydroxystearic acid; alumina-treated ZnO dispersed in a mixture of ethylhexyl methoxycinnamate / PVP-hexadecene / polymethylsiloxane copolymer; ZnO coated with silica and polymethylsilsesquioxane; ZnO dispersed in hydroxystearic acid condensate; or ZnO coated with a mixture of stearoylglutamic acid, jojoba ester, polyhydroxystearic acid, isopropoxytitanium triisostearate, hydrogenated olive oil stearyl ester, cetearyl nonanoate, beeswax and sodium stearoyl lactylate.
[0101] Also preferred are granular UV filters or inorganic pigments, which may optionally be hydrophobic, such as oxides of iron (Fe2O3), oxides of zirconium (ZrO2), oxides of silicon (SiO2), oxides of manganese (e.g., MnO), oxides of aluminum (Al2O3), oxides of cerium (e.g., Ce2O3), oxides of barium carbonate (BaCO3), oxides of calcium carbonate (CaCO3), or mixtures thereof.
[0102] In one embodiment, the sunscreen composition, cosmetic composition, or home care composition preferably comprises at least one water-soluble UV filter, such as phenylbenzimidazole sulfonic acid (PBSA), sodium sulfonyl isobenzophenone, benzyl camphor sulfonic acid, camphor benzalkonium methyl sulfate, sinoxalate, disodium phenyl dibenzimidazole tetrasulfonate, terephthalimide dicamphor sulfonic acid, PABA, and PEG-25 PAB; and any mixture thereof.
[0103] To optimize SPF, i.e., to achieve a high SPF in the range of 6 to 100, preferably in the range of 6 to 70, and to cover a wide range of UVA and UVB, the sunscreen composition or cosmetic composition according to the invention comprises at least three, preferably at least four, or even more different organic and / or inorganic UV filters, i.e., particularly organic UV filters and / or inorganic pigments (UV filtering pigments). Such compositions according to the invention are particularly suitable for protecting skin and hair.
[0104] SPF was determined using the "COLIPA International Method for Testing Sun Protection Factors" (COLIPA, May 2006), which measures the increase in the skin redness threshold (minimum erythema dose, MED) after standardized application of photoprotective agents as a function of exposure time.
[0105] Advantageously, the sunscreen compositions or cosmetic compositions according to the invention comprise at least one UVA filter and at least one UVB filter. Such sunscreen compositions or cosmetic compositions according to the invention provide broad-spectrum light protection, i.e., protection against both UVA and UVB.
[0106] Combinations of different types of effective sunscreen UV filters (such as UVA filters, UVB filters, broadband filters, and inorganic pigments) provide reliable protection against various UV rays in the wavelength range of 290nm to 400nm.
[0107] In another preferred embodiment, the sunscreen composition or cosmetic composition of the present invention comprises a combination with one, two, three or more broadband filter agents selected from the group consisting of: 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, ethyl-2-cyano-3,3'-diphenylacrylate, dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, sodium hydroxymethoxybenzophenone sulfonate, disodium-2,2'-dihydroxy-4,4'-dimethoxy- 5,5'-Disulfonylbenzophenone, phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyl)propyl, 2,2'-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)phenol (methylene-bisbenzotriazolyltetramethylbutylphenol), 2,4-bis-[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-1,3,5-triazine, 2,4-bis-[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (INCI: Anis) oTriazin), 2,4-bis-[{(4-(3-sulfonic acid)-2-hydroxypropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine sodium salt, 2,4-bis-[{(3-(2-propoxy)-2-hydroxypropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-[4-(2-methoxyacetyl)phenylamino]-1,3,5-triazine, 2,4-bis-[{4-(3-(2-propoxy)-2-hydroxypropoxy)-2-hydroxy}phenyl]-6-[4-(2-ethylcarboxyl)phenylamino] -1,3,5-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(1-methylpyrrolo-2-yl)-1,3,5-triazine, 2,4-bis-[{4-tris-(trimethylsiloxysilylpropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4-bis-[{4-(2''-methpropenyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4-bis-[{4-(T,T,T,3',5',5',5'-heptamethylsiloxy-2''-methylpropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4-bis-[{4-(T,T,T,3',5',5',5'-heptamethylsiloxy-2''-methylpropoxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-Triazine, dioctylbutamidotriazinone (INCI: diethylhexylbutamidotriazinone), 2,4-bis-[5-1-(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-ethylhexyl)-imino-1,3,5-triazine, 4,4',4''-(1,3,5-triazine-2,4,6-triisopropyltriimino)tribenzoate tris(2-ethylhexyl ester) (also known as: 2,4,6-tris[anilino(p-carbonyl-2'-ethyl-1'-hydroxyhexyl)]-1,3,5-triazinone (INCI: octyltriazinone), 2,4,6 -Triphenyl-4-yl-1,3,5-triazine, 2-ethylhexyl-4-methoxycinnamate (ethylhexylmethoxycinnamate), benzoic acid, 2-hydroxy-3,3,5-trimethylcyclohexyl ester (humosalilate), 2-ethylhexyl salicylate (ethylhexyl salicylate), 2-ethylhexyl-4-(dimethylamino)benzoate (dimethyl PABA ethylhexyl ester), N,N,N-trimethyl-4-(2-oxoboron-3-methylenemethyl)aniline methyl sulfate (camphor benzalkonium methyl sulfate), dimethyl diethyl benzoyl malonate (polysiloxane-15), and mixtures thereof.
[0108] The sunscreen composition or cosmetic composition according to the invention optionally contains at least one film-forming agent. "Optional" means that a film-forming agent is not mandatory in the sunscreen composition or cosmetic composition according to the invention, but may be advantageously incorporated. Film-forming agents are well known in the art as agents for improving the water resistance of sunscreen products.
[0109] Film-forming agents are hydrophobic materials that impart water resistance and film-forming properties to sunscreen compositions or cosmetic compositions. Typical suitable film-forming agents include copolymers derived from the polymerization of 1-octadecene and maleic anhydride. Preferred film-forming agents are polyanhydride resins. Another preferred film-forming agent is a copolymer of vinylpyrrolidone and eicosene monomers.
[0110] Standard film-forming agents include chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymer, acrylic polymers, quaternary ammonium cellulose derivatives, collagen, hyaluronic acid and their salts and similar compounds.
[0111] According to the present invention, these film-forming agents are preferably selected from the group consisting of: polyamide-8 (such as Oleocraft LP 20 PA (MV)), polyamide-3 (such as Oleocraft MP 32 PA (MV)), trimethylpentanediol / adipic acid / glycerol crosspolymers (such as wet films), octyl dodecyl alcohol citrate crosspolymers (such as CosmoSurf CE 100), polyglycerol-3-methyl glucoside distearate (such as TegoCare 450), C28-52 olefin / undecenoic acid copolymers (such as Performa V6112), hydrolyzed jojoba esters, jojoba esters, aqueous solutions (such as Floraester jojoba K100), cyclopentasiloxane acrylate / dimethylpolysiloxane copolymers (such as KP545), acrylate / behenol polyether-25 methacrylate copolymers (such as Volarest), styrene / acrylate copolymers (such as Dermacryl E polymer), polyurethanes (such as Baycusan) C1001), polyurethane-2 and polymethyl methacrylate (such as Hybridur 875 polymer), acrylate / octylacrylamide copolymer (such as Dermacryl 2.0 polymer), beeswax (white beeswax) (and) sodium stearoyl lactylate (such as SymEffektSun), amylopectin, xanthan gum, microcrystalline cellulose (and) Sphingomonas fermentation extract (and) cellulose gum (such as PemuPur) ™ START polymers), gum arabic, and xanthan gum (such as SOLAGUM) ™ AX), microcrystalline cellulose (and) cellulose gum (such as Natpure Cellgum Enhanced), sodium stearoyl glutamate (such as AMISOFT) ® HS-11P), hydrogenated polycyclopentadiene (and) caprylic / capric triglycerides (such as Koboguard) ® 5400 CCT), glyceryl hydrorosinate (and) caprylic / capric triglycerides (and) tocopherols (such as KOBOGUARD) ® NATURAL 2063-CCT), galactoarabinogalactan (such as LaraCare) ® A 200), C26-28 alkyl polydimethylsiloxanes (such as Wacker BELSIL) ® CDM 3526VP), octanoyl methyl siloxanes (such as Silsoft 034), stearyl polydimethicone (and) octadecene (such as Dowsil 2503 cosmetic wax), VP / hexadecene copolymers (such as Antaron) ™ V 216), triacontyl PVP (such as Antaron) ™WP-660), capryloyl glycerol / sebacic acid copolymer (such as LexFilm) ™ Sun Natural MB), polyC10-30 alkyl acrylates (such as Tego SP 13 Sun Up), microcrystalline cellulose (such as Sunspheres) ™ BIO SPF enhancer), hydrogenated palm oil, sugarcane extract and beeswax (Cera Alba), sodium stearoyl lactylate and any mixture thereof.
[0112] More preferably, these film-forming agents are preferably selected from the group consisting of: trimethylpentanediol / adipic acid / glycerol crosspolymers (such as wet films), octyl dodecyl alcohol citrate crosspolymers (such as CosmoSurf CE 100), polyglycerol-3-methyl glucoside distearate (such as TegoCare 450), C28-52 olefin / undecenoic acid copolymers (such as Performa V6112), hydrolyzed jojoba esters, jojoba esters, aqueous solutions (such as Floraester jojoba K100), cyclopentasiloxane acrylate / dimethylpolysiloxane copolymers (such as KP545), styrene / acrylate copolymers (such as Dermacryl E polymer), acrylate / octylacrylamide copolymers (such as Dermacryl 2.0 polymer), beeswax (white beeswax) (and) sodium stearoyl lactylate (such as SymEffect) Sun), amylopectin, xanthan gum, microcrystalline cellulose (and) Sphingomonas fermentation extract (and) cellulose gum (such as Pemupur) ™ START polymers), gum arabic, and xanthan gum (such as SOLAGUM) ™ AX), microcrystalline cellulose (and) cellulose gum (such as Natpure Cellgum Enhanced), sodium stearoyl glutamate (such as AMISOFT) ® HS-11P), hydrogenated polycyclopentadiene (and) caprylic / capric triglycerides (such as Koboguard) ® 5400CCT), glyceryl hydropine resin ester (and) caprylic / capric triglyceride (and) tocopherols (such as KOBOGUARD) ® NATURAL 2063-CCT), galactoarabinogalactan (such as LaraCare) ® A 200), C26-28 alkyl polydimethylsiloxanes (such as Wacker BELSIL) ® CDM 3526 VP), octanoyl methyl siloxanes (such as Silsoft 034), stearyl polydimethicone (and) octadecenes (such as Dowsil 2503 cosmetic wax), VP / hexadecene copolymers (such as Antaron)™ V 216), triacontyl PVP (such as Antaron) ™ WP-660), capryloyl glycerol / sebacic acid copolymer (such as LexFilm) ™ Sun NaturalMB), polyC10-30 alkyl acrylates (such as Tego SP 13 Sun Up), microcrystalline cellulose (such as Sunspheres) ™ BIOSPF enhancers and any mixture thereof.
[0113] More preferably, these film-forming agents are selected from the group consisting of: hydrolyzed jojoba ester, jojoba ester, aqueous solutions (such as Floraester jojoba K100), cyclopentasiloxane acrylate / dimethicone copolymers (such as KP545), styrene / acrylate copolymers (such as Dermacryl E polymer), acrylate / octylacrylamide copolymers (such as Dermacryl 2.0 polymer), beeswax (white beeswax) (and) sodium stearoyl lactylate (such as SymEffect Sun), amylopectin, xanthan gum, microcrystalline cellulose (and) Sphingomonas fermentation extracts (and) cellulose gums (such as PemuPur ™ START polymers), microcrystalline cellulose (and) cellulose gums (such as NatpureCellgum Enhanced), hydrogenated polycyclopentadiene (and) caprylic / capric triglycerides (such as Koboguard) ® 5400 CCT), glyceryl hydrorosinate (and) caprylic / capric triglycerides (and) tocopherols (such as KOBOGUARD) ® NATURAL 2063-CCT), galactoarabinogalactan (such as LaraCare) ® A 200), C26-28 alkyl dimethicone (such as Wacker BELSIL) ® CDM 3526 VP), stearyl polydimethicone (and) octadecene (such as Dowsil 2503 cosmetic wax), VP / hexadecene copolymer (such as Antaron) ™ V 216), triacontyl PVP (such as Antaron) ™ WP-660), capryloyl glycerol / sebacic acid copolymer (such as LexFilm) ™ SunNatural MB), polyC10-30 alkyl acrylates (such as Tego SP 13 Sun Up), microcrystalline cellulose (such as Sunspheres) ™ BIO SPF enhancers and any mixture thereof.
[0114] The aforementioned film-forming agent is used as a single component or preferably in a mixture with two or more other film-forming agents in a sunscreen composition or cosmetic composition.
[0115] In addition to the aforementioned group of organic and / or inorganic sunscreen UV filters, antioxidant-type secondary sunscreen ingredients may also be advantageously used in sunscreen compositions, cosmetic compositions, or home care compositions according to the invention to further optimize UV protection.
[0116] Secondary sunscreen ingredients of the antioxidant type interrupt the photochemical reaction chain that is triggered when UV rays penetrate the skin.
[0117] Typical examples of secondary sunscreen ingredients are amino acids (e.g., arginine, lysine, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g., uric acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g., anserine), carotenoids, carotenes (e.g., alpha-carotene, beta-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g., dihydrolipoic acid), thioglucose, propylthiouracil and other thiols (e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl... Acyl, methyl, ethyl, propyl, pentyl, butyl, lauryl, palmitoyl, oleyl, α-linolenic acid, cholesterol, and their glycerides) and their salts, very small compatible doses of dilauryl thiodipropionate, distearate thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides, and salts), and sulfonylamine compounds (e.g., sulfonyl butyrate, sulfocysteine, sulfone butyrate, pentathionine, hexathionine, and heptathionine sulfonylamine), as well as (metal) chelating agents (e.g., α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), and α-hydroxy acids (e.g., citric acid, lactic acid, malic acid). Humic acid, bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g., linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and panthenol and their derivatives, vitamin C and its derivatives (e.g., ascorbate palmitate, Mg ascorbate phosphate, ascorbate acetate), tocopherol and its derivatives (e.g., vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), and coniferyl benzoate of benzoin resin, rutin and its derivatives, saccharitoline, ferulic acid, furfuryl alcohol, carnosine, butylated hydroxytoluene, Butylated hydroxyanisole, nordihydroguaiacol, nordihydroguaiacol, trihydroxybutanone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, sinapic acid, sinapicoyl malate, sinapic acid ester derivatives, titanium dioxide (e.g., dispersions in ethanol), zinc and its derivatives (e.g., ZnO, ZnSO4), selenium and its derivatives (e.g., selenomethionine selenoside), stilbene and its derivatives (e.g., stilbene oxide, trans-stilbene oxide), methoxyphenyliminodimethylcyclohexenylglycine ethyl ester, and derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides, and lipids) of these active substances suitable for the purposes of this invention.
[0118] The secondary sunscreen ingredient group also includes plant-based extracts. These plant-based extracts possess antioxidant and general photoprotective properties and interrupt the photochemical reaction chain initiated when UV rays penetrate the skin, thus effectively preventing skin aging. Plant extracts with UV-protective properties are selected from the group consisting of: lignin / cellulose, lignin, hydrolyzed lignin, propolis and green propolis, galangal extract, macroalgae and microalgae (Porphyra, red algae (Porphyra umbilicalis)), palmaria palmata (Saccharina latissimi), small coral algae (Corallina pilulifera), kelp (Eckloina cava), deep-sea Sargassum (Sargassum sagamianum), rose laver (Porphyra) *Rosengurttii*, *Sargassum siliquastrum*, *Thalassiosiraweissflogii*, green microalgae (e.g., *Interfilum* and *Klebsormidium*), seaweed (e.g., *Padina australis*, *Euchemacottonii*, *Pongamia Glabra* seed oil, *Millettia pinnata* oil, *Rhatania Extrakt* (*Kramerialappacea*), lichens, soybean, caper (*Capparis spinosa*), bamboo, green coffee oil, *Buriti Oil* (*Mauritia flexuosa*), black sea cucumber (*Holothuria*). atra, cyanobacteria, Fernblock (Polypodium leucotomos), green tea, black tea (Camelliasinensis), aloe vera, walnut, borage oil, evening primrose oil, avocado oil, tea tree oil, red clover (Trifolium pratense L.), soybean (Glycine max L.), caper flower buds (caper), almond, flame tree (Spathodea campanulata), milk thistle (Silybum marianum L.).Cashew shells, grapes, red oranges, pomegranate (Punicagranatu), European blueberry (Vaccinium myrtillus L.), Bog blueberry (Vaccinium uliginosum L.), strawberry (Fragaria annassa), Polygonum multiflorum Thunb. (Foti), Curcuma longa L. (Turmeric), Ginseng (Panax ginseng), Englishivy (Hederahelix), broccoli (Brassica oleracea var. italica), tamarind (Tamarindus indica), prickly pear cactus (Opuntia ficus-indica), coffee, basil (Ocimum basilicum, Linn.), pomegranate seed oil (Punica granatu). Granatum), wheat germ oil (wheat (Triticum vulgare)), blackcurrant seed oil (blackcurrant (Ribesnigrum)), sesame oil (sesame (Sesamum indicum)), carrot root (carrot (Daucus carota sativa)), raspberry seed oil (raspberry (Rubus idaeus)), Sri Lankan traditional medicinal plants (Aporosalindleyana (Euphorbiaceae), Atalantiaceylanica (Rutaceae), Hibiscus furcatus (Malvaceae), Olaxzeylanica (Olacaceae), Ophiorrhiza mungos (Rubiaceae), Argyreia populifolia (Convolvulaceae), Ipomoea mauritiana (Convolvulaceae), Lasiaspinosa (Araceae), Leucas zeylanica (Lamiaceae), Plectranthus zeylanicus (Lamiaceae), and the seeds of D. gardneriana, a traditional Brazilian medicinal plant.Leaves of *Microphylla microphylla*, *Amburana cearensis*, *Aspidospermacuspa*, *Aspidospermapyrifolium*, *Croton sonderianus*, *Curatella americana*, *Dimophandragardneriana*, *Lippia microphylla*, *Lueheapaniculata*, *Sidagalheirensis*, and any mixtures thereof.
[0119] Preferably, the plant extracts with UV protection properties are selected from the group consisting of: lignin / cellulose, lignin, hydrolyzed lignin, Alpinia galanga extract, Porphyra, red algae (Porphyra umbellata), green microalgae (e.g., Endophyta and Kerria), seaweed (e.g., Fania serrata, Euphorbia tirucalli), *Cynanchum paniculatum* seed oil, *Sophora japonica* oil, *Latanni* extract (burdock cone), soybean, bamboo, *Bridge fruit* oil, cyanobacteria, *Pteris vittata*, green tea, black tea, evening primrose oil, cashew nut shell, pomegranate, and any mixture thereof.
[0120] Based on the total weight of the ready-to-use formulation, the amount of secondary sunscreen substance in the sunscreen composition or cosmetic composition or cosmetic composition according to the invention is advantageously from 0.005% by weight to 5.0% by weight, preferably from 0.01% by weight to 4.0% by weight, and most preferably from 0.05% by weight to 3.0% by weight.
[0121] UV filters are incorporated into the aqueous or lipophilic portions of sunscreen or cosmetic compositions, depending on whether they are water- or oil (lipid) soluble / miscible UV filters, or can even be added to the final product by standard methods known to those skilled in the art.
[0122] Based on the total weight of the final formulation, at least one organic and / or inorganic UV filter according to the invention is present in the sunscreen composition or cosmetic composition in an amount from 0.01% to 80.0% by weight. In a preferred embodiment, the sunscreen composition or cosmetic composition comprises an amount from 0.1% to 75.0% by weight of organic and / or inorganic UV filter based on the total weight of the final formulation. In a more preferred embodiment, the UV filter is advantageously used in the sunscreen composition or cosmetic composition in an amount from 0.5% to 70.0% by weight based on the total weight of the final formulation. In a more preferred embodiment, the UV filter is advantageously used in the sunscreen composition or cosmetic composition in an amount from 1.0% to 60.0% by weight based on the total weight of the final formulation.
[0123] For mixtures of organic and / or inorganic UV filters, the above amount refers to the total content of UV filters in the mixture, i.e., the amount is the sum of the contents of all major UV filters in the mixture.
[0124] Based on the total weight of the final formulation, organic and / or inorganic UV filters and additional UV protective components, such as secondary sunscreen ingredients or secondary sunscreen UV filters (i.e., the total amount of UV filters), are present in the sunscreen composition or cosmetic composition according to the invention in an amount ranging from 0.1% by weight to 85.0% by weight. In a preferred embodiment, the sunscreen product, cosmetic, or pharmaceutical preparation contains 0.3% by weight to 80.0% by weight of organic and / or inorganic UV filters and additional UV protective components as defined herein, based on the total weight of the final formulation. In a more preferred embodiment, UV filters and additional UV protective components, as defined herein, are advantageously used in the sunscreen composition or cosmetic composition in an amount ranging from 0.5% by weight to 75.0% by weight, based on the total weight of the final formulation. Therefore, the above amounts relate to the sum of the contents of all UV filters / UV protective components present in the sunscreen, cosmetic, or pharmaceutical preparation.
[0125] The sunscreen compositions or cosmetic compositions according to the invention provide broad-spectrum light protection and thus protection against both UVA and UVB radiation. Sunscreen factor (SPF) is a measure of UVB protection. Typically, the compositions of the invention have an SPF of at least 6. However, the SPF can be varied as needed. The type and amount of UVA and UVB filters can be varied to achieve the desired SPF level. Preferably, the sunscreen compositions or cosmetic compositions according to the invention have an SPF of at least 6, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, or even higher.
[0126] The sunscreen composition, cosmetic composition, or home care composition of the present invention further comprises at least one excipient and / or cosmetic or pharmaceutically active substance selected from the group consisting of: carriers, oil components, rheology modifiers, water-soluble growth promoters, solubilizers, powders, film-forming agents, water resistance improvers, skin moisturizing and / or water-retaining substances, soothing substances, physiological coolants, antioxidants, anti-skin aging agents, matrix metalloproteinase inhibitors (MMPIs), anti-inflammatory agents, TRPV1 antagonists, emulsifiers, preservatives, antibacterial or antifungal active substances, chelating agents, surfactants, fragrances / perfumes or perfume oils, and any mixture of two or more of the above substances.
[0127] As sunscreen compositions or cosmetic compositions as defined herein are intended for topical application, such as in the form of ointments, pastes, creams, and gels, they are preferably carrier-based. The most common acceptable carrier is water. Acceptable carriers other than water include glycerin, C1-4 alcohols, organic solvents, fatty alcohols, fatty ethers, fatty esters, polyols, ethylene glycol, vegetable oils, mineral oils, liposomes, layered lipid materials, water, or mixtures thereof. Non-limiting examples of organic solvents include monohydric and polyhydric alcohols such as ethanol, isopropanol, propanol, benzyl alcohol, and phenethyl alcohol, or ethylene glycol or ethylene glycol ethers, such as monomethyl ethers, monoethyl ethers, and monobutyl ethers of, for example, ethylene glycol, propylene glycol, or their ethers, such as monomethyl ethers of, for example, propylene glycol, butanediol, hexanediol, and dipropylene glycol, and alkyl ethers of diethylene glycol, such as monoethyl or monobutyl ethers of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butanediol, hexanediol, propylene glycol, and glycerin. The organic solvent can be a volatile or non-volatile compound. The total amount of the carrier in the composition can vary, but is typically 40% to 90% by weight based on the total weight of the composition.
[0128] The sunscreen composition or cosmetic composition according to the present invention may contain at least one UV filter stabilizer that stabilizes the UV filter and thereby enhances its efficacy, said at least one UV filter stabilizer being selected from the group consisting of: 2-[(5,5-dimethyl-3-phenylimino-cyclohexen-1-yl)amino]acetic acid, 2-[(3-phenylimino-cyclohexen-1-yl)amino]acetic acid, 2,5,5-trimethyl-3-(phenylimino)cyclohexen-1-yl-glycine, 2-[(2-methyl-3-phenylimino-cyclohexen-1-yl)amino]acetic acid, 3- ((3,4-Dimethoxyphenyl)imino)-5,5-dimethylcyclohexyl-1-en-1-yl-glycine, 3-((3,4-dimethoxyphenyl)imino)cyclohexyl-1-en-1-yl-glycine, 3-((3,4-dimethoxyphenyl)imino)-2,5,5-trimethylcyclohexyl-1-en-1-yl-glycine, 2-[(3-(3,4-dimethoxyphenyl)imino-2-methyl-cyclohexen-1-yl)amino]acetic acid, 2-[(5,5-dimethyl-3-(4-sulfophenyl)imino-cyclohexen-1-yl)amino]acetic acid, 2-[(3-(4-) [Sulfophenyl)iminocyclohexen-1-yl)amino]acetic acid, 2,5,5-trimethyl-3-((4-sulfophenyl)imino)cyclohex-1-en-1-yl-glycine, 2-methyl-3-((4-sulfophenyl)imino)cyclohex-1-en-1-yl-glycine, 2-[(5,5-dimethyl-3-phenylimino-cyclohexen-1-yl)amino]acetamide, 2-[(3-phenyliminocyclohexen-1-yl)amino]acetamide, 2-((2,5,5-trimethyl-3-(phenylimino)cyclohexen-1-yl)amino)acetamide, 2-((2-methyl- 3-(phenylimino)cyclohexyl-1-en-1-yl)amino)acetamide, 2-((3-((3,4-dimethoxyphenyl)imino)-5,5-dimethylcyclohexyl-1-en-1-yl)amino)acetamide, 2-[(3-(3,4-dimethoxyphenyl)iminocyclohexyl-1-yl)amino]acetamide, 2-((3-((3,4-dimethoxyphenyl)imino)-2,5,5-trimethylcyclohexyl-1-en-1-yl)amino)acetamide and 2-((3-((3,4-dimethoxyphenyl)imino)-2-methylcyclohexyl-1-en-1-yl)amino)acetamide.
[0129] The compositions of the present invention may comprise at least one water-soluble or organic solvent. Non-limiting examples of organic solvents include monohydric and polyhydric alcohols, such as ethanol, isopropanol, propanol, benzyl alcohol, and phenethyl alcohol; or ethylene glycol or ethylene glycol ethers, such as monomethyl ethers, monoethyl ethers, and monobutyl ethers of, for example, ethylene glycol, propylene glycol, or their ethers; monomethyl ethers of, for example, propylene glycol, butanediol, hexanediol, and dipropylene glycol; and alkyl ethers of diethylene glycol, such as monoethyl ethers or monobutyl ethers of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butanediol, hexanediol, propylene glycol, and glycerol. The organic solvent may be a volatile or non-volatile compound.
[0130] Other non-limiting examples of water-soluble solvents include alkanols (polyols, such as ethylene glycol and polyols), such as glycerol, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butanediol, hexanediol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6- Hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-buten-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, and 4-methyl-1,2-pentanediol; alkyl alcohols having one to four carbon atoms, such as ethanol, methyl... Alcohols, butanol, propanol, and isopropanol; ethylene glycol ethers, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, diethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-tert-butyl ether, diethylene glycol mono-tert-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether ... Ethyl ether, propylene glycol mono-tert-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-isopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, and dipropylene glycol monoisopropyl ether; 2-pyrrolidone, N-methyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolinone, formamide, acetamide, dimethyl sulfoxide, sorbitol, dehydrated sorbitol, acetic acid, diacetic acid, triacetic acid, sulfolane, and any mixtures thereof. The total amount of water-soluble or organic solvent in the compositions according to the invention may vary, but is generally from 0.1% by weight to 50% by weight based on the total weight of the composition.
[0131] The compositions of the present invention may include at least one solubilizer. A solubilizer is a compound that helps dissolve UV-filters and / or other components in the composition. A particularly useful, but not limiting, example of a solubilizer is a water-soluble growth promoter. Water-soluble growth promoters (or water-soluble aids) are a different class of typical water-soluble compounds characterized by an amphiphilic molecular structure and a significant ability to increase the solubility of poorly soluble organic molecules in water. Non-limiting examples of water-soluble growth promoters include sodium 1,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate, sodium salicylate, sodium benzenesulfonate, caffeine, sodium p-toluenesulfonate, sodium butyl monoethylene glycol sulfate, HCl of 4-aminobenzoic acid, sodium cumenesulfonate, N,N-diethylnicotinamide, N-pyridinemethylnicotinamide, N-allylnicotinamide, 2-methacryloyloxyethylphosphorylcholine, resorcinol, butylurea, pyrogallol, N-pyridinemethylacetamide 3.5, procaine HCl, proline HCl, nicotinamide, pyridine, 3-pyridinemethylamine, ibuprofen sodium, sodium xylenesulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N,N-dimethylacetamide, N-methylacetamide, and isoniazid, and any mixtures thereof. In some cases, particularly useful water-soluble growth promoters include nicotinamide, caffeine, sodium PCA, sodium salicylate, urea, and dihydroxyethyl urea, especially nicotinamide and / or caffeine. Combinations of two or more, three or more, or four or more water-soluble growth promoters can also be used in the compositions according to the invention. The total amount of solubilizer in the compositions of the invention can vary, but is typically from 0.01% by weight to 20% by weight based on the total weight of the composition.
[0132] Sunscreen compositions or cosmetic compositions may include at least one oil phase or at least one oil component, wax, starch, tragacanth gum, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, and zinc oxide, or any mixture thereof. Powders include carriers such as lactose, talc, silica, aluminum hydroxide, calcium silicate, and polyamide powders, or any mixture thereof. Solutions and emulsions include carriers such as solvents such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, propylene glycol, etc., or any mixture thereof. However, entirely water-based formulations are also possible. Oil, oil-in-water, and water-in-oil emulsions are preferred.
[0133] The sunscreen composition or cosmetic composition according to the invention may be suitable for an oil phase or oil component, such as vegetable oil, hydrocarbon, fatty alcohol, fatty acid ester, or a mixture of two or more of the aforementioned oil components.
[0134] The oil phase or oil component in a sunscreen composition or cosmetic composition is preferably a vegetable oil, and even more preferably a liquid vegetable oil. It can also advantageously be a mixture of two or more vegetable oil components, especially a liquid vegetable oil mixture.
[0135] Vegetable oils are oils extracted from seeds, or less commonly from other parts of the fruit. Similar to animal fats, vegetable oils are mixtures of triglycerides. Soybean oil, rapeseed oil, and cocoa butter are examples of vegetable oils derived from seeds. Olive oil, palm oil, and rice bran oil are examples of oils derived from other parts of the fruit. In common usage, "vegetable oil" may specifically refer to vegetable fats that are liquid at room temperature or at a skin temperature of 35°C to 37°C. Vegetable oils are generally edible.
[0136] The term "vegetable oil" also includes unsaturated vegetable oils. Unsaturated oils, or vegetable oils, can be converted into oils with higher melting points through partial or complete "hydrogenation." Hydrogenation involves "spraying" the oil with hydrogen gas at high temperatures and pressures in the presence of a catalyst (usually a powdered nickel compound). When each carbon-carbon double bond is chemically reduced to a single bond, two hydrogen atoms each form a single bond with two carbon atoms. Eliminating double bonds by adding hydrogen atoms is called saturation; as the degree of saturation increases, the oil progresses towards complete hydrogenation. Oils can be hydrogenated to increase their resistance to rancidity (oxidation) or to alter their physical properties. With increasing saturation, the viscosity and melting point of the oil increase.
[0137] In a preferred embodiment, the vegetable oil is selected from the group consisting of: avocado (Persea Gratissima / Avocado) oil, European fir (Abies Alba) seed oil, Acacia Victoriae seed oil, Actinidia Chinensis kiwi seed oil, Amaranthus Hypochondriacus seed oil, Arachis Hypogaea / Peanut oil, Astrocaryum Murumuru seed oil, Astrophicum Tucuma seed oil, Astrophicum Tucuma seed oil, Astrocaryum Vulgare fruit oil, Astrocaryum Vulgare kernel oil, and Avena cava. Sativa / Oat seed oil, white mustard (Brassica Alba) seed oil, rapeseed (Brassica Campestris / Rapeseed) seed oil, shea butter (Butyrospermum Parki / Shea) resin, shea butter (Butyrospermum Parki / Shea) oil, calendula officinalis seed oil, crabapple (Calophyllum Inophyllum) seed oil, calendula (Calophyllum Tacamahaca) seed oil, camellia (Camellia Oleifera) seed oil, Yunnan camellia (Camellia Reticulata) seed oil, tea tree (Camellia Sinensis) seed oil, hemp seed oil, hemp seed / stem oil (Cannabis Sativa Seed / Stem Oil), low erucic acid rapeseed oil (Canola Oil), safflower (Carthamus Tinctorius / Safflower) seed oil, common chlorella oil (Chlorella Vulgaris) Oils including: Watermelon (Citrullus Lanatus / Watermelon) seed oil, Lime (Citrus Aurantifolia / Lime) seed oil, Sweet Orange (Citrus Aurantium Dulcis) (Orange) seed oil, Grapefruit (Citrus Grandis / Grapefruit) seed oil, Coconut (Cocos Nucifera / Coconut) oil, Coconut (Cocos Nucifera / Coconut) seed butter, Coffee (Coffea Arabica) seed oil, Chlorella oil (biotechnology), and American hazelnut (Corylus).Americana (hazelnut) seed oil, European hazelnut (Corylus Avellana) seed oil, melon (Cucumis Melo) seed oil, cucumber (Cucumis Sativus / Cucumber) seed oil, zucchini (Cucurbita Pepo / Pumpkin) seed oil, oil palm (Elaeis Guineensis) (palm) oil, oil palm (Elaeis) (palm) fruit oil, wild soybean (Glycine Soja) (soybean) oil, cottonseed (Gossypium Herbaceum) (cottonseed) oil, upland cotton (Gossypium Hirsutum) (cottonseed) oil, sunflower (Helianthus Annuus / Sunflower) seed oil, macadamia nut (Macadamia Integrifolia) seed oil, macadamia nut (Macadamia Ternifolia) seed oil, mango (Mangifera Indica / Mango) seed butter, mango (Mangifera Indica / Mango) seed oil, lemon balm (Melissa) Officinalis seed oil, microalgae oil, Moringa oleifera seed oil, European Moringa seed oil, Evening primrose oil, Olea Europaea olive oil, Olus oil, Orbignya oleifera seed oil, Orbignya Speciosa kernel oil, Oryza Sativa rice bran / germ oil, rice bran oil, rice germ oil, rice lipids, rice seed oil, Papaver somniferum seed oil, Passiflora edullis seed oil, Persea Gratissima avocado lipids, avocado oil, Sweet almond oil, Prunus amygdalus Dulcis, Prunus apricot oil. Armeniaca / Apricot kernel oil, Prunus Persica / Peach kernel oil, Punica Granatum seed oil, Pyrheat Malus / Apple seed oil, Ricinoleic / Caproic / Caprylic / Capric Triglyceride, Castor (Ricinus)Communis / Castor seed oil, Rosa Canina fruit oil, Rosa Moschata seed oil, Rubus Idaeus / Raspberry seed oil, Sesamum Indicum / Sesame seed oil, Soybean Glycerides, Theobroma Cacao / Cocoa seed oil, Theobroma Grandiflorum seed oil, Triticum Vulgare / Wheat bran oil, Triticum Vulgare / Wheat germ oil, Vitis Vinifera / Grape seed oil, Zea Mays / Corn germ oil, and Zea Mays / Corn oil.
[0138] The aforementioned plant oils are the most common natural lipid components used as base substances in the manufacture of cosmetics or pharmaceutical formulations.
[0139] Hydrocarbons (mineral oils) are typically organic compounds composed entirely of hydrogen and carbon. As defined by IUPAC nomenclature or organic chemistry, hydrocarbons are classified as follows: 1. Saturated hydrocarbons are the simplest type of hydrocarbon. They are composed entirely of single bonds and are hydrogen-saturated. The chemical formula of acyclic saturated hydrocarbons (i.e., alkanes) is C64-C ... n H 2n+2 The most common form of saturated hydrocarbons is C64. n H 2n+2(1-r) ,in r It refers to the number of rings. Those with exactly one ring are cycloalkanes. Saturated hydrocarbons are the basis of petroleum fuels and exist in the form of straight-chain or branched compounds.
[0140] 2. Unsaturated hydrocarbons have one or more double or triple bonds between carbon atoms. Those with double bonds are called alkenes. Those with one double bond have the formula C0. n H 2n (Assuming a non-cyclic structure). Those containing a triple bond are called alkynes. Those with one triple bond have the formula C. n H 2n−2 .
[0141] 3. Aromatic hydrocarbons, also known as aromatic hydrocarbons, are hydrocarbons that have at least one aromatic ring.
[0142] Hydrocarbons can be liquids (e.g., hexane and benzene), waxes, or low-melting-point solids (e.g., paraffin and naphthalene). The term "aliphatic" refers to non-aromatic hydrocarbons. Saturated aliphatic hydrocarbons are sometimes referred to as "paraffins." Mineral oils and waxes are primarily mixtures of saturated hydrocarbons with straight, branched, and cyclic structures and carbon chains longer than C14. Mineral oils and waxes are chemicals prepared from naturally occurring crude oils. They are primarily composed of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). For decades, hydrocarbons have been used in skin and lip care cosmetic products due to their excellent skin tolerance, high protective and cleansing properties, and wide range of viscosity options. Compared to vegetable oils, mineral oils are non-allergenic because they are highly stable and less prone to oxidation or rancidity.
[0143] Fatty alcohols (or long-chain alcohols) are typically high-molecular-weight, straight-chain primary alcohols, but their range can be as few as 4 to 6 carbons to as many as 22 to 26 carbons (derived from natural fats and oils). The exact chain length varies depending on the source. Some commercially important fatty alcohols are lauryl alcohol, stearyl alcohol, and oleyl alcohol. They are colorless, oily liquids (for smaller carbon numbers) or waxy solids, but impure samples may appear yellow. Fatty alcohols typically have an even number of carbon atoms and a single alcohol group (-OH) attached to the terminal carbon. Some are unsaturated, and some are branched. Most fatty alcohols found in nature exist in the form of waxes, which are esters of fatty acids and fatty alcohols. The traditional sources of fatty alcohols are mostly various vegetable oils, and these vegetable oils remain large-scale feedstocks. Alcohols are obtained from triglycerides (fatty acid triesters), the main component of oils. This method involves transesterification of triglycerides to obtain methyl esters, which are then hydrogenated to obtain fatty alcohols. Fatty alcohols are also prepared from petrochemical sources. In the Ziegler process, ethylene is oligomerized using triethylaluminum, followed by air oxidation. Alternatively, ethylene can be oligomerized to obtain a mixture of olefins, which is then hydroformylated to yield odd-numbered aldehydes, which are subsequently hydrogenated. Fatty alcohols are primarily used in the production of detergents and surfactants. They are also components of cosmetic solvents. They are used in cosmetics as co-emulsifiers, emollients, and thickeners.
[0144] In a preferred embodiment, the fatty alcohol is selected from the group consisting of: phenylpropanol, dimethylphenylbutanol, hexyldecyl alcohol, octyldodecyl alcohol, octyldecyl alcohol, tridecyl alcohol, isostearyl alcohol, phenylisohexanol, phenylpropanol, trimethylphenylpropanol, isoamyl alcohol, isostearyl alcohol, and isotearyl alcohol. In a more preferred embodiment, the fatty alcohol is selected from the group consisting of: hexyldecyl alcohol, octyldodecyl alcohol, phenylpropanol, isoamyl alcohol, and mixtures of two or more of the above-mentioned fatty alcohols. The fatty alcohol can be used as a single component or in the form of a mixture with one or more other different fatty alcohols mentioned above.
[0145] Fatty acid esters are a class of esters produced by combining fatty acids with alcohols. When the alcohol component is glycerol, the resulting fatty acid esters can be monoglycerides, diglycerides, or triglycerides. Fatty acid esters have a conditioning effect that softens the skin to produce a smooth feel. They are also added to cosmetics to dissolve highly polar active ingredients and UV absorbers. Esters of straight-chain fatty acids and lower alcohols are effective at dissolving slightly soluble ingredients, used to give oils a gentle feel during application. Isostearic acid and other liquid oils containing branched-chain fatty acids and unsaturated fatty acids are commonly used as emollients. Higher fatty acid esters and higher alcohol esters with relatively high melting points are added to skin creams to adjust the feel during application.
[0146] In addition to the oil phase or oil component as defined above, the sunscreen composition or cosmetic composition according to the present invention preferably contains one or more oil bodies. Suitable oil bodies for forming O / W emulsions include, for example, gerbert alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms; esters of straight-chain C5-C22 fatty acids with straight-chain or branched C5-C22 fatty alcohols; or esters of branched C1-C13 carboxylic acids with straight-chain or branched C6-C22 fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearate myristate, stearate palmitate, stearate stearate, and so on. Stearic acid stearate, oleic acid stearate, behenic acid stearate, erucic acid stearate, myristic acid isostearate, palmitic acid isostearate, stearic acid isostearate, isostearic acid isostearate, oleic acid isostearate, behenic acid isostearate, oleic acid isostearate, myristic acid oleate, palmitic acid oleate, stearic acid oleate, isostearic acid oleate, oleic acid oleate, behenic acid oleate, erucic acid oleate, myristic acid behenicate, palmitic acid behenicate, stearic acid behenicate, isostearic acid behenicate, oleic acid behenicate, behenic acid behenicate, behenic acid erucic acid ester, myristic acid myrosyl ester, palmitic acid myrosyl ester, stearic acid myrosyl ester, isostearic acid myrosyl ester, oleic acid myrosyl ester, behenic acid myrosyl ester and erucic acid myrosyl ester. Also suitable are esters of straight-chain C6-C22 fatty acids with branched-chain alcohols, particularly 2-ethylhexanol; esters of C18-C38 alkyl hydroxycarboxylic acids with straight-chain or branched C6-C22 fatty alcohols, particularly dioctyl malate; esters of straight-chain and / or branched-chain fatty acids with polyols (such as, for example, propylene glycol, dimerols, or trimersols) and / or guerbert alcohols; triglycerides based on C6-C10 fatty acids; liquid mono- / di- / triglyceride mixtures based on C6-C18 fatty acids; esters of C6-C22 fatty alcohols and / or guerbert alcohols with aromatic carboxylic acids, particularly benzoic acid; esters of C2-C12 dicarboxylic acids with straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; vegetable oils; branched primary alcohols; substituted cyclohexanes; and straight-chain and branched C6-C22 fatty alcohol carbonates such as, for example, dioctyl carbonate (Cetiol). ® (CC), based on aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms, with straight-chain and / or branched C6-C6 carbon atoms. 22 Benzoate esters of alcohols (e.g., Finsolv) ® TN), a dialkyl ether having a straight or branched chain of 6 to 22 carbon atoms per alkyl group, symmetrical or asymmetrical, such as, for example, dioctyl ether (Cetiol).® OE), ring-opening products of epoxidized fatty acid esters and polyols, silicone oils (cyclomethylsiloxanes, siloxane methylsiloxanes, etc.) and / or aliphatic or cycloalkanes such as squalane, squalene or dialkylcyclohexane.
[0147] The sunscreen compositions or cosmetic compositions according to the invention can be advantageously combined with other standard cosmetic excipients and / or active ingredients and / or additives and / or auxiliaries, such as those commonly used in such compositions, such as, for example, abrasives, anti-acne agents, anti-skin aging agents, anti-cellulite agents, anti-dandruff agents, anti-inflammatory agents, antimicrobial agents, irritant preventatives, irritant inhibitors, antioxidants, astringents, odor absorbers, antiperspirants, bactericides, antistatic agents, binders, buffers, carrier materials, chelating agents. Cell stimulants, cleansers, depilatories, surfactants, deodorants, antiperspirants, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibers, film-forming agents, color-fixing agents, foam-forming agents, foam stabilizers, defoamers, foam promoters, gelling agents, gelling agents, hair conditioning agents, hair styling agents, hair straighteners, humectants, moisturizing substances, water-retaining substances, whitening agents, strengthening agents, detergents, optical brighteners, impregnating agents, stain repellents, dyes, friction reducers, lubricants, moisturizing creams, ointments, sunscreens, plasticizers, covering agents. Polishing agents, preservatives, gloss agents, green and synthetic polymers, powders, proteins, fatliquoring agents, abrasives, siloxanes, skin soothing agents, skin cleansers, skin care products, skin healing agents, skin brighteners, skin protectants, skin softeners, hair activators, cooling agents, skin cooling agents, warming agents, skin warming agents, stabilizers, surfactants, detergents, fabric conditioning agents, suspending agents, skin tanning agents, active ingredients that regulate skin or hair pigmentation, matrix metalloproteinase inhibitors, skin moisturizers, glycosaminoglycan stimulants, TRPV1 antagonists, stripping and dissolving agents, fat-reducing agents or fat-reducing agents, hair growth activators or inhibitors, thickeners, rheological additives, vitamins, oils, waxes, pearlescent waxes, fats, phospholipids, saturated fatty acids, monounsaturated or polyunsaturated fatty acids, α-hydroxy acids, polyhydroxy fatty acids, liquefying agents, dyes, color protectants, pigments, corrosion inhibitors, fragrances or perfume oils, flavoring agents, flavoring substances, odor substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the above substances, as further described below.
[0148] In the aforementioned cosmetics, excipients and / or active substances and / or additives and / or auxiliaries, such as emollients, rheology modifiers, siloxanes, dryness modifiers, skin moisturizing and / or water-retaining substances, soothing substances, physiological coolants, antioxidants, emulsifiers, antimicrobial agents, preservatives, fragrances or aromatic oils, and any mixture of two or more of the aforementioned substances, are particularly preferred in the preparation of sunscreen compositions or cosmetic compositions.
[0149] Oils and emollients: The sunscreen or cosmetic compositions according to the invention advantageously comprise one or more oils or emollients. Emollients are oily or greasy substances that help smooth and soften the skin and can also reduce skin roughness, dryness, or irritation. In particular, in sunscreen products, emollients counteract the known stickiness of some UV filters and keep crystalline and oil-soluble organic and inorganic UV filters in a dissolved state, preventing their recrystallization. Furthermore, emollients act as wetting agents for inorganic UV filters to ensure their uniform dispersion in the formulation. Suitable oils are, for example, gerberas based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, with a straight-chain C6-C6 chain. 22 - Fatty acids and straight-chain or branched C6-C 22 -Esters of fatty alcohols, or branched C6-C 13 -Carboxylic acids with straight-chain or branched C6-C 22 -Esters of fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, myristyl stearate, palmitate stearate, stearyl stearate, isostearate stearate, oleic acid stearate, behenate stearate, erucic acid stearate, myristyl isostearate, palmitate isostearate, stearic acid Isostearate, isostearic acid isostearate, oleic acid isostearate, behenic acid isostearate, oleic acid isostearate, myristate oleate, palmitic oleate, stearic acid oleate, isostearic acid oleate, oleic acid oleate, behenic acid oleate, erucic acid oleate, myristate behenic acid, palmitic behenic acid, stearate behenic acid, isostearic acid behenic acid, oleic acid behenic acid, behenic acid behenic acid, behenic acid erucic acid, myristate sinapeptide, palmitic sinapeptide, stearate sinapeptide, isostearic acid sinapeptide, oleic acid sinapeptide, behenic acid sinapeptide, and erucic acid sinapeptide. Also suitable is linear C6-C. 22 -Esters of fatty acids and branched-chain alcohols, especially 2-ethylhexanol, C 18 -C 38 -alkyl hydroxycarboxylic acids with straight-chain or branched C6-C 22 - Esters of fatty alcohols, particularly dioctyl malate, straight-chain and / or branched-chain fatty acids with polyols (such as, for example, propylene glycol, dimerols, or trimers) and / or guerbert alcohols, based on C6-C 10 Triglycerides of fatty acids, based on C6-C 18 -A liquid mixture of mono- / di- / triglycerides of fatty acids, C6-C 22- Esters of fatty alcohols and / or guerbert alcohols with aromatic carboxylic acids, particularly benzoic acid, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, straight-chain and branched C6-C... 22 - Fatty alcohol carbonates such as, for example, dioctyl carbonate (Cetiol) ® (CC), based on aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms, with straight-chain and / or branched C6-C6 carbon atoms. 22 - Benzoate esters of alcohols (e.g., Finsolv) ® TN), a dialkyl ether having a straight or branched chain of 6 to 22 carbon atoms per alkyl group, symmetrical or asymmetrical, such as, for example, dioctyl ether (Cetiol). ® OE), ring-opening products of epoxidized fatty acid esters and polyols, silicone oils (cyclomethylsiloxanes, siloxane-methylsiloxanes, etc.) and / or aliphatic or cycloalkanes such as, for example, squalane, squalene or dialkylcyclohexane, and any mixture thereof.
[0150] In a preferred embodiment, the sunscreen composition or cosmetic composition according to the invention comprises a blend comprising ethylhexyl acetoxystearate; diethylhexyl 2,6-naphthalenedicarboxylate and / or dimethyl isosorbide and propylene glycol dioctanoate / decanoate, as described in PCT / EP2022 / 081701.
[0151] Rheology modifier: The sunscreen composition or cosmetic composition according to the invention advantageously comprises one or more thickeners and / or rheology modifiers. The rheology modifier is present in an amount that prevents the composition from significantly dripping or agglomerating after application to the skin. Preferably, the rheology modifier is carbomer. In some embodiments, the rheology modifier is selected from stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, stearyl alcohol polyethylene glycol ether having an average of about 1 to about 21 ethylene oxide units, cetyl alcohol polyethylene glycol ether having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.
[0152] Further examples of rheology modifiers include thickeners or gelling agents, including substances that can increase the viscosity of a composition. Thickeners include those that can increase the viscosity of a composition without substantially altering the efficacy of the active ingredient in the formulation. Thickeners can also increase the stability of the formulations of this application. In some aspects of this application, thickeners include hydrogenated polyisobutylene or trihydroxystearin, or mixtures of both. Further non-limiting examples of other thickeners that can be used in the context of this application include carboxylic acid polymers, cross-linked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include cross-linked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acid, and salts and esters of such acrylic and substituted acrylic acids, wherein the cross-linking agent contains two or more carbon-carbon double bonds and is derived from polyols (see CTFA International Cosmetic Ingredient Dictionary, 4th Edition, 1991, pp. 12 and 80). Examples of commercially available carboxylic acid polymers include carbomer, which is an acrylic homopolymer crosslinked with allylic ethers of sucrose or pentaerythritol (e.g., Carbopol from BF Goodrich). ™ (900 series). Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers.
[0153] Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers, including substituted branched or linear polymers) include polyacrylamide, isoparaffins and lauryl ether-7, acrylamide and substituted acrylamide multiblock copolymers with acrylic acid and substituted acrylic acid.
[0154] Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is alkyl-substituted cellulose, wherein the hydroxyl groups of the cellulose polymer are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form hydroxyalkylated cellulose, which is then further modified by C10-C30 straight-chain or branched alkyl groups via ether bonds. Typically, these polymers are ethers of C10-C30 straight-chain or branched alcohols with hydroxyalkylated cellulose. Other useful polysaccharides include stearans, which comprise a straight chain of (1 to 3) linked glucose units, with each three units having (1 to 6) linked glucose units.
[0155] Non-limiting examples of gums that can be used with the compositions of the present invention include gum arabic, agar, alginate, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar gum hydroxypropyltrimethylammonium chloride, lithium montmorillonite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar gum, black privet gum, giant kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextrin, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof. In one embodiment, the thickener is an extract of Chondrus crispus (carrageenan).
[0156] Water Resistance Modifier: The sunscreen composition or cosmetic composition according to the invention may advantageously contain one or more agents for improving water resistance. The agent for improving water resistance is a hydrophobic material that imparts film-forming and water-resistant properties to the emulsion. Typical suitable water resistance modifiers include copolymers derived from the polymerization of octadecene-1 and maleic anhydride. Preferred water resistance modifiers are polyanhydride resins. Another preferred water resistance modifier is a copolymer of vinylpyrrolidone and eicosene monomers. The water resistance modifier is used in an effective amount that allows the final formulation to remain on the skin or surface after exposure to circulating water for at least 40 minutes, preferably 80 minutes. Based on the total weight of the final formulation, one or more water resistance modifiers may optionally be included in the final formulation in an amount from 0.01% to 10.0% by weight, preferably from 0.05% to 8.0% by weight, more preferably from 0.1% to 5.0% by weight.
[0157] Siloxanes: To impart a smooth, spreadable, and luxurious texture and make the skin look and feel smoother, and additionally improve processability (anti-foaming), sunscreen products, cosmetics, or pharmaceutical formulations according to the invention preferably contain one or more siloxanes or siloxane derivatives. Suitable siloxanes may be selected from the group consisting of: theophylline methylsilanol mannouronate, acetyl methionyl methylsilanol elastomeric acrylate / behenyl, acrylate / dimethylsiloxane methacrylate copolymer, acrylate / behenyl methacrylate / dimethylsilicone methacrylate copolymer, acrylate / dihydroxypropyl polydimethylsiloxane crosspolymer, acrylate / polydimethylsiloxane copolymer, acrylate / polydimethylsiloxane methacrylate / ethylhexyl acrylate copolymer, acrylate / polydimethylsiloxane acrylate copolymer, acrylate / ethylhexyl acrylate / dimethylsiloxane methacrylate copolymer, acrylate, acrylate, ethylhexyl acrylate, dimethylsiloxane methacrylate copolymer, acrylate, acrylate, dimethylsiloxane, methacrylate ... dimethylsiloxane, acrylate, dimethylsiloxane, methacrylate, dimethylsiloxane, methacrylate, dimethylsiloxane, acrylate, dimethylsiloxane, methacrylate, dimethylsiloxane, methacrylate, dimethylsiloxane, methacrylate, Acrylic acid ester / octylacrylamide / diphenylaminodimethylsiloxane copolymer, acrylate / polytrimethylsiloxymethacrylate copolymer, acrylate / propyl methacrylate copolymer, acrylate / stearyl acrylate / dimethylsiloxane methacrylate copolymer, acrylate / tridecyl acrylate / triethoxysilylpropyl methacrylate / dimethylsiloxane copolymer, acrylate / trifluoropropyl methacrylate / polymethyl methacrylate copolymer, aminodipropylpolydimethylsiloxane, aminoethylaminopropylpolydimethylsiloxane, aminopropylpolydimethylsiloxane, aminopropylphenyltrimethylsiloxane, aminopropyltriethoxysilane Polydimethylsiloxane PEG-7 ammonium sulfate, aminodimethylsiloxane, aminodimethylsiloxane hydroxystearate, aminodimethylsiloxane / sesquioxane copolymer, ascorbic acid carboxydecyl trisiloxane, ascorbic acid methylsilanol pectate, behenoxydimethyl silicone oil, behenyl polydimethylsiloxane PEG-8 phthalate, behenyl polydimethylsiloxane, diaminoPEG / PPG-41 / 3 aminoethyl PG-propyl polydimethylsiloxane, diaminopropyl / ethoxyaminopropyl dimethylsiloxane, bis(butyl benzoate) diaminotriazine aminopropyl trisiloxane, dibutyl polydimethylsiloxane polyglycerol-3, dibutoxy polydimethylsiloxane PEG-60 copolymer, bis(C13-15 alkoxy)hydroxybutylaminodimethyl silicone oil, bis(C13-15 alkoxy)PG-aminodimethyl silicone oil, bis-(C1-8 alkyllauroyl lysine decylformamide)dimethyl silicone oil, bis-hexadecylhexadecyldimethyl silicone oil, bis-hexadecyl / PEG-8 hexadecyl PEG-8 dimethyl silicone oil, bis-diphenylethyldisiloxane, bis-ethylethylmethylsiloxane, bis-glucamidoethylaminopropyldimethylsiloxane, dihydropolydimethylsiloxane, dihydroxyethoxypropylpolydimethylsiloxane, dihydroxylauryl, polydimethylsiloxane / IPDI copolymerDihydroxy / methoxyaminodimethylsiloxane, dihydroxypropyl dimethylsiloxane behenate, dihydroxypropyl dimethylsiloxane / SMDI copolymer, diisobutyl PEG-14 / aminodimethylsiloxane copolymer, diisobutyl PEG-15 / aminodimethylsiloxane copolymer, diisobutyl PEG / PPG-20 / 35 / aminodimethylsiloxane copolymer, diisobutyl PEG / PPG-10 / 7 / dimethylsiloxane copolymer, diisobutyl PEG-24 / PPG-7 / polydimethylsiloxane copolymer, bis-PEG-1 polydimethylsiloxane, bis-PEG-4 polydimethylsiloxane, bis-PEG-8 polydimethylsiloxane, bis-PEG-12 polydimethylsiloxane, bis-PEG-20 polydimethylsiloxane Methylsiloxane, bis-PEG-12 polydimethylsiloxane beeswax, bis-PEG-12 dimethylsiloxane candelilla resin, bis-PEG-15 dimethylsiloxane / IPDI copolymer, bis-PEG-15 methyl ether dimethylsiloxane, bis-PEG-18 methyl ether dimethylsiloxane, bis-PEG / PPG-14 / 14 polydimethylsiloxane, bis-PEG / PPG-15 / 5 polydimethylsiloxane, bis-PEG / PPG-18 / 6 polydimethylsiloxane, bis-PEG / PPG-20 / 20 polydimethylsiloxane, bis-PEG / PPG-16 / 16 polydimethylsiloxane, bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 polydimethylsiloxane, bisphenylhexamethyl Siloxanes, bisphenylpropyl polydimethylsiloxane, bispolyethylene polydimethylsiloxane, bis-(polyglycerol-3-oxyphenylpropyl) polydimethylsiloxane, bis-(polyglycerol-7-oxyphenylpropyl) polydimethylsiloxane, bis-PPG-15 polydimethylsiloxane / IPDI copolymer, bis(PPG-7 undecenyl-21) polydimethylsiloxane, bisstearyl polydimethylsiloxane, bis-trimethoxysilylethyltetramethyldisiloxyethyl polydimethylsiloxane, divinyl polydimethylsiloxane, divinyl polydimethylsiloxane / polydimethylsiloxane copolymer, borage seed oil PEG-7 polydimethylsiloxane ester, butyl acrylate / C6-14 perfluoroalkyl ethyl acrylate / mercaptopropyl polydimethylsiloxane Alkyl copolymers, butyl acrylate / hydroxypropyl polydimethylsiloxane acrylate copolymers, polydimethylsiloxane butyl acrylate / cyclohexyl methacrylate / ethylhexyl acrylate copolymers, butyl polydimethylsiloxane / methyl methacrylate crosspolymers, tert-butyl dimethylsilyl grape seed extract, butyl polydimethylsilyl ethylene / propylene / vinyl norbornene copolymers, C6-8 alkyl C3-6 alkyl glucoside polydimethylsiloxane, C20-24 alkyl polydimethylsiloxane, C24-28 alkyl polydimethylsiloxane, C26-28 alkyl polydimethylsiloxane, C30-45 alkyl polydimethylsiloxane, C30-60 alkyl polydimethylsiloxane, C32 alkyl polydimethylsiloxane...C30-45 alkyl polydimethylsiloxane / polycyclohexene oxide crosslinked polymer, C26-28 alkyl dimethylsilyl polypropyl silsesquioxane, C30-45 alkyl dimethylsilyl polypropyl silsesquioxane, C20-24 alkyl methylsiloxane, C24-28 alkyl methylsiloxane, C26-28 alkyl methylsiloxane, C30-45 alkyl methylsiloxane, C20-28 alkyl perfluorodecylethoxy polydimethylsiloxane, C26-54 alkyl tetradecyl polydimethylsiloxane, octyl polydimethylsiloxane Octyl polydimethylsiloxane ethoxy glucoside, octyl polydimethylsiloxane, octyl polytrimethylsiloxane, carboxydecyltrisiloxane, castor oil dihydroxypropyl polydimethylsiloxane ester wax-based polydimethylsiloxane, cetearyl polydimethylsiloxane crosslinked polymer, cetearyl polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer, cetearyl polydimethylsiloxane, hexadecyltrimethylammonium carboxydecyl PEG-8 polydimethylsiloxane, hexadecyltrimethylammonium polydimethylsiloxane PEG-7 phthalate, decadecyl polydimethylsiloxane, etc. Hexaalkylhexyl polydimethylsiloxane, hexadecyl polydimethylsiloxane, hexadecyl polydimethylsiloxane / bisvinyl polydimethylsiloxane crosspolymer, hexadecylhexadecyl-1 polydimethylsiloxane, hexadecylhexacoSY-1 dimethylsiloxane, hexadecyloxy polydimethylsiloxane, hexadecyl PEG-8 polydimethylsiloxane, hexadecyl PEG / PPG-15 / 15 butyl ether polydimethylsiloxane, hexadecyl PEG / PPG-7 / 3 polydimethylsiloxane, hexadecyl PEG / PPG -10 / 1 Polydimethylsiloxane, hexadecyltriethylammonium polydimethylsiloxane PEG-8 phthalate, hexadecyltriethylammonium polydimethylsiloxane PEG-8 succinate, acetyltyrosine copper methylsilanol, PCA methylsilanol copper, C4-14 perfluoroalkylethoxy polydimethylsiloxane, cycloethoxymethylsiloxane, cycloheptane, cyclohexylsiloxane, cyclomethylsiloxane, cyclopentane, cyclophenylmethylsiloxane, cyclotetrasiloxane, m-cyclovinylmethylsiloxane, cystine bis-PG-propylsilanetriol, DEA PG-propyl PEG / PPG-18 / 21 polydimethylsiloxane, bisisostearoyl trimethylolpropane siloxysilicate, dilauroyl trimethylolpropane siloxysilicate, dilinoleamide propyl dimethylamine polydimethylsiloxane PEG-7 phosphate, polydimethylsiloxane, polydimethylsiloxane crosspolymer, polydimethylsiloxane crosspolymer-3, polydimethylsiloxane / divinyl polydimethylsiloxane / sesquioxane crosspolymer, polydimethylsiloxane ethoxy glucoside, polydimethylsiloxane hydroxypropyl ammonium trichloride, polydimethylsiloxane / mercaptopropyl polydimethylsiloxane copolymer, polydimethylsiloxane PEG-15 acetate, polydimethylsiloxane PEG-8 adipate.Polydimethylsiloxane PEG-7 avocado ester, polydimethylsiloxane PEG-8 avocado ester, polydimethylsiloxane PEG-8 beeswax, polydimethylsiloxane PEG-8 benzoate, polydimethylsiloxane PEG-8 borate, polydimethylsiloxane PEG-7 cocoate, polydimethylsiloxane / PEG-10 crosspolymer, polydimethylsiloxane / PEG-10 / 15 crosspolymer, polydimethylsiloxane / PEG-15 crosspolymer, polydimethylsiloxane PEG-7 isostearate, polydimethylsiloxane PEG-8 isostearate, polydimethylsiloxane PEG-7 lactate, polydimethylsiloxane PEG-8 lanolin ester, polydimethylsiloxane PEG-8 laurate, polydimethylsiloxane... Dimethylsiloxane PEG-8 Potamogeton oil ester, Dimethylsiloxane PEG-7 Octyldodecyl citrate, Dimethylsiloxane PEG-7 Olive ester, Dimethylsiloxane PEG-8 Olive ester, Dimethylsiloxane PEG-7 Phosphate, Dimethylsiloxane PEG-8 Phosphate, Dimethylsiloxane PEG-10 Phosphate, Dimethylsiloxane PEG-7 Phthalate, Dimethylsiloxane PEG-8 Phthalate, Dimethylsiloxane PEG-8 Polyacrylate, Dimethylsiloxane PEG / PPG-20 / 23 Benzoate, Dimethylsiloxane PEG / PPG-7 / 4 Phosphate, Dimethylsiloxane PEG / PPG-12 / 4 Phosphate Polydimethylsiloxane PEG-7 succinate, polydimethylsiloxane PEG-8 succinate, polydimethylsiloxane PEG-7 sulfate, polydimethylsiloxane PEG-7 undecenoate, polydimethylsiloxane PG-diethylammonium chloride, polydimethylsiloxane / phenylvinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane / polyglycerol-3 crosspolymer, polydimethylsiloxane / PPG-20 crosspolymer, polydimethylsiloxane propyl ethylenediamine behenate, polydimethylsiloxane propyl PG-betaine, polydimethylsiloxane / silsesquioxane copolymer, polydimethylsiloxane silyl ester, polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, polydimethylsiloxane / vinyl triethylene ... Methylsiloxane-oxysilicate crosspolymer, polydimethylsiloxane alcohol, polydimethylsiloxane alcohol arginine, polydimethylsiloxane alcohol beeswax, polydimethylsiloxane alcohol behenate, polydimethylsiloxane alcohol borate, polydimethylsiloxane alcohol candelilla ester, polydimethylsiloxane alcohol carnauba palmitate, polydimethylsiloxane alcohol cysteine, polydimethylsiloxane alcohol boswellia oleate, polydimethylsiloxane alcohol fluoroalcohol dilinoleic acid, polydimethylsiloxane alcohol hydroxystearate, polydimethylsiloxane alcohol ILLipe ester, polydimethylsiloxane alcohol / IPDI copolymer, polydimethylsiloxane alcohol isostearate, polydimethylsiloxane alcohol candelilla oleate, polydimethylsiloxane alcohol lactate, polydimethylsiloxane alcohol pondweed oleate.Polydimethylsiloxane methionine, polydimethylsiloxane / methylsiloxane / silicate crosspolymer, polydimethylsiloxane longleaf lignosulfonate, polydimethylsiloxane panthenol, polydimethylsiloxane sal ester, polydimethylsiloxane / silica crosspolymer, polydimethylsiloxane / sesquioxane copolymer, polydimethylsiloxane stearate, polydimethylsiloxane / stearyl, methylsiloxane / phenyl polytrimethylsiloxane copolymer, dimethoxysilyl ethylenediaminopropyl polydimethylsiloxane, dimethylaminopropylamide PCA polydimethylsiloxane, dimethyloxobenzodioxane, dimethylsiloxane hyaluronic acid ester, dioleoyl tocopherol methylsiloxane, diphenylamino polydimethylsiloxane Oxyalkane, diphenyl polydimethylsiloxane, diphenyl polydimethylsiloxane cross-linked polymer, diphenyl polydimethylsiloxane / sesquioxane cross-linked polymer, diphenylethylbenzyloxydimethylsiloxane, diphenylisopropyl polydimethylsiloxane, diphenylsiloxyphenyl / propyl polytrimethylsiloxane, diphenylsiloxyphenyl polytrimethylsiloxane disiloxane, amino polydimethylsiloxane disuccinate disodium, PEG-12 polydimethylsiloxane disodium sulfosuccinate, PEG-8 lauryl polydimethylsiloxane disodium sulfosuccinate, divinyl polydimethylsiloxane / polydimethylsiloxane copolymer, cresoltrazol trisiloxane, ethylhexyl acrylate / VP / polydimethylsiloxane methacrylate copolymer, ethylmethylsiloxane Oxyalkyl, Ethyltrisiloxane, Fluorinated C2-8 alkyl polydimethylsiloxane, Glucoamidopropylaminopropyl polydimethylsiloxane, 4-(2-β-glucopyranose siloxy)propoxy-2-hydroxybenzophenone, Polydimethylsiloxane decylglycerol ether, Polydimethylsiloxane alkyl epoxypropyl ether, Hexadecylmethylsiloxane, Hexyl polydimethylsiloxane, Hexylmethylsiloxane, Hexyltrimethoxysilane, Hydrogen-dimethylsiloxane, Hydrogen-dimethylsiloxane / octylsilsesquioxane copolymer, Hydrolyzed collagen PG-propyldimethylsiloxane alcohol, Hydrolyzed collagen PG-propylmethylsilane diol, Hydrolyzed collagen PG-propylsilane triol, Hydrolyzed keratin-PG-propylmethylsilane diol, Hydrolyzed sesame protein-PG-propylmethylsilane triol PG-propylmethylsilanediol, hydrolyzed silk PG-propylmethylsilanediol crosspolymer, hydrolyzed soybean protein / polydimethylsiloxane PEG-7 acetate, hydrolyzed soybean protein PG-propylmethylsilanediol, hydrolyzed plant protein-PG-propylsilanetriol, hydrolyzed wheat protein / cystine bis-PG-propylsilanetriol copolymer, hydrolyzed wheat protein / polydimethylsiloxane PEG-7 acetate, hydrolyzed wheat protein / polydimethylsiloxane PEG-7 phosphate copolymer, hydrolyzed wheat protein PG-propylmethylsilanediol, hydrolyzed wheat protein PG-propylsilanetriol, hydroxyethyl acetone PG-polydimethylsiloxane, hydroxypropyl polydimethylsiloxane, hydroxypropyl polydimethylsiloxane behenate.Hydroxypropyl polydimethylsiloxane isostearate, hydroxypropyl dimethyl silicone stearate, isobutyl methacrylate / dimethylsiloxane bis(hydroxypropyl) acrylate copolymer, isobutyl methacrylate / trifluoroethyl methacrylate / dimethylsiloxane bis(hydroxypropyl) acrylate copolymer, isoamyl trimethoxycinnamate trisiloxane, isopolyglycerol-3 polydimethylsiloxane, isopolyglycerol-3 dimethylsiloxane alcohol, isopolyglycerol-3 dimethylsiloxane alcohol, isopropyl titanium triisostearate / triethoxysilyl ethyl, polydimethylsiloxane crosspolymer, isostearyl carboxydecyl PEG-8 polydimethylsiloxane, lactoyl methylsilanol elastomeric acid ester, lauryl polydimethylsiloxane, lauryl polydimethylsiloxane Methylsiloxane PEG-15 crosspolymer, lauryl polydimethylsiloxane PEG-10 phosphate, lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, lauryl methylsiloxane, lauryl PEG-8 polydimethylsiloxane, lauryl PEG-10 methyl ether polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, lauryl PEG / PPG-18 / 18 methylsiloxane, lauryl phenyl isopropyl methylsiloxane, lauryl phenyl propyl methylsiloxane, lauryl polydimethylsiloxane / bisvinyl dimethylsiloxane crosspolymer, lauryl polyglycerol-3 polydimethylsiloxane oxyethyl polydimethylsiloxane, lauryl polytrimethylsiloxane, linoleic acid Aminopropyl PG-diammonium phosphate polydimethylsiloxane, methacrylpropyltrimethoxysilane, methylsiloxane, methoxyaminodimethylsiloxane / silsesquioxane copolymer, methoxycinnamoylpropyl polysilsesquioxane, methoxycinnamoylpropyl silsesquioxane silicate, methoxyPEG-13ethyl polysilsesquioxane, methoxyPEG / PPG-7 / 3 aminopropyl polydimethylsiloxane, methoxyPEG / PPG-25 / 4 polydimethylsiloxane, methoxyPEG-10propyltrimethoxysilane, methyleugenylPEG-8 polydimethylsiloxane, methyl polysiloxane emulsion, methylsilanol acetylmethanesulfonate, methylsilanol acetyltyrosine, methylsilanol ascorbate, methylsilanol carboxymethyl theophylline Methylsilanol carboxymethyl theophylline alginate, methylsilanol elastase, methylsilanol glycyrrhizate, methylsilanol hydroxyproline, methylsilanol hydroxyproline aspartate, methylsilanol mannouronate, methylsilanol PCA, methylsilanol PEG-7 glyceryl cocoate, methylsilanol / silicate crosspolymer, methylsilanol spirulinaate, methylsilanol tri-PEG-8 glyceryl cocoate, methyl polytrimethylsiloxane, methyltrimethoxysilane, myristamidopropyl dimethylamine dimethyl silicone PEG-7 phosphate, myristyl methylsiloxane, myristyl trisiloxane, nylon-611 / dimethylsiloxane copolymer, PCA polydimethylsiloxane, PEG-7 amino polydimethylsiloxane.PEG-8 amino polydimethylsiloxane, PEG-8 hexadecyl polydimethylsiloxane, PEG-3 polydimethylsiloxane, PEG-6 polydimethylsiloxane, PEG-7 polydimethylsiloxane, PEG-8 polydimethylsiloxane, PEG-9 polydimethylsiloxane, PEG-10 polydimethylsiloxane, PEG-12 polydimethylsiloxane, PEG-14 polydimethylsiloxane, PEG-17 polydimethylsiloxane, PEG-10 polydimethylsiloxane crosspolymer, PEG-12 polydimethylsiloxane crosspolymer, PEG-8 polydimethylsiloxane dimer dilinoleate, PEG-8 polydimethylsiloxane / dimer dilinoleic acid copolymer, PEG-10 polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, PEG-8 distearate ammonium chloride P G-polydimethylsiloxane, PEG-10 / lauryl polydimethylsiloxane crosspolymer, PEG-15 / lauryl polydimethylsiloxane crosspolymer, PEG-15 / lauryl polydimethylsiloxane crosspolymer, PEG-8 methylsiloxane, PEG-6 methylsiloxane acetate, PEG-6 methyl ether polydimethylsiloxane, PEG-7 methyl ether polydimethylsiloxane, PEG-8 methyl ether polydimethylsiloxane, PEG-9 methyl ether polydimethylsiloxane, PEG-10 methyl ether polydimethylsiloxane, PEG-11 methyl ether polydimethylsiloxane, PEG-32 methyl ether polydimethylsiloxane, PEG-8 methyl ether triethoxysilane, PEG-10 nonafluorohexyl polydimethylsiloxane copolymer, PEG-4 PEG-12 polydimethylsiloxane, PEG-8 PG-cocoa-glucoside polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, PEG / PPG-20 / 22 butyl ether polydimethylsiloxane, PEG / PPG-22 / 22 butyl ether polydimethylsiloxane, PEG / PPG-23 / 23 butyl ether polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-27 / 9 butyl ether polydimethylsiloxane, PEG / PPG-3 / 10 polydimethylsiloxane, PEG / PPG-4 / 12 polydimethylsiloxane, PEG / PPG-6 / 4 polydimethylsiloxane, PEG / PPG-6 / 11 polydimethylsiloxane, PEG / PPG-8 / 14 polydimethylsiloxane, PEG / PPG-8 / 26 polydimethylsiloxane, PEG / PPG-10 / 2 polydimethylsiloxane, PEG / PPG-12 / 16 polydimethylsiloxane, PEG / PPG-12 / 18 polydimethylsiloxane, PEG / PPG-14 / 4 polydimethylsiloxane, PEG / PPG-15 / 5 polydimethylsiloxane, PEG / PPG-15 / 15 polydimethylsiloxane, PEG / PPG-16 / 2 polydimethylsiloxane, PEG / PPG-16 / 8 polydimethylsiloxane,PEG / PPG-17 / 18 polydimethylsiloxane, PEG / PPG-18 / 6 polydimethylsiloxane, PEG / PPG-18 / 12 polydimethylsiloxane, PEG / PPG-18 / 18 polydimethylsiloxane, PEG / PPG-19 / 19 polydimethylsiloxane, PEG / PPG-20 / 6 polydimethylsiloxane, PEG / PPG-20 / 15 polydimethylsiloxane, PEG / PPG-20 / 20 polydimethylsiloxane, PEG / PPG-20 / 23 polydimethylsiloxane, PEG / PPG-20 / 29 polydimethylsiloxane, PEG / PPG-22 / 23 polydimethylsiloxane, PEG / PPG-22 / 24 polydimethylsiloxane Alkane, PEG / PPG-23 / 6 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane, PEG / PPG-27 / 27 polydimethylsiloxane, PEG / PPG-30 / 10 polydimethylsiloxane, PEG / PPG-25 / 25 polydimethylsiloxane / acrylate copolymer, PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG / PPG-24 / 24 methyl ether glycidyl oxydimethylsiloxane, PEG / PPG-10 / 3 oil-based ether polydimethylsiloxane, PEG / PPG-5 / 3 trisiloxane, PEG-4 trifluoropropyl dimethylsiloxane copolymer, PEG-8 trifluoropropyl dimethylsiloxane copolymer, PEG -10 Trifluoropropyl Polydimethylsiloxane Copolymer, PEG-8 Trisiloxane, Perfluorooctylethoxysilylethylmethylsiloxane, Perfluorononyl Polydimethylsiloxane, Perfluorononyl Polydimethylsiloxane / Methylsiloxane / Amino Polydimethylsiloxane Crosspolymer, Perfluorononylethylcarboxydecylbenzyl Polydimethylsiloxane, Perfluorononylethylcarboxydecyl HexacoSY-l Polydimethylsiloxane, PerfluorononylethylcarboxydecylLauryl / Behenyl Polydimethylsiloxane, Perfluorononylethylcarboxydecyl Polydimethylsiloxane, Perfluorononylethylcarboxydecyl PEG-8 Polydimethylsiloxane, Perfluorononylethylcarboxydecyl PEG-10 Polydimethylsiloxane, Perfluorononylethyl Polydimethylsiloxane / Methylsiloxane copolymers, perfluorononylethyl PEG-8 polydimethylsiloxane, perfluorononylethyl stearyl polydimethylsiloxane, perfluorooctylethyl / diphenyl polydimethylsiloxane copolymers, perfluorooctylethyl triethoxysilane, perfluorooctylethyl trimethoxysilane, perfluorooctylethyl trisiloxane, perfluorooctyltriethoxysilane, PG-aminomethylsiloxane, phenethyl polydimethylsiloxane, phenethyl disiloxane, phenyl polydimethylsiloxane, phenyl isopropyl polydimethylsiloxane, phenylmethylsiloxane, phenylmethyl silicone alcohol, phenylpropyl dimethylsiloxysilicate, phenylpropyl ethyl methylsiloxane, phenylpropyl polytrimethylsiloxane, phenylpropyl polytrimethylsiloxane / diphenylmethylsiloxane, phenyl polytrimethylsiloxanePlatinum divinyldisiloxane, polyacrylate-6, polydiethylsiloxane, polydimethylsiloxyethyl polydimethylsiloxane / bisvinyl polydimethylsiloxane crosspolymer, polydimethylsiloxyethyl polydimethylsiloxane / methylsiloxane copolymer, polydimethylsiloxyPEG / PPG-24 / 19 butyl ether silsesquioxane, polydimethylsiloxyPPG-13 butyl ether silsesquioxane, polyglycerol-3 disiloxane polydimethylsiloxane, polyglycerol-3 / lauryl polydimethylsiloxyethyl polydimethylsiloxane crosspolymer, polyglycerol-3 polydimethylsiloxyethyl polydimethylsiloxane, polyethylene adipate / dihydroxyethoxypropyl polydimethylsiloxane copolymer, polymethylsilsesquioxane, polymethylsilsesquioxane / trimethylsiloxysilicate, polyphenylsilsesquioxane, polypropylsilsesquioxane, polysiloxane-1 Polysiloxane-2, Polysiloxane-3, Polysiloxane-4, Polysiloxane-5, Polysiloxane-6, Polysiloxane-7, Polysiloxane-8, Polysiloxane-9, Polysiloxane-10, Polysiloxane-11, Polysiloxane-12, Polysiloxane-13, Polysiloxane-14, Polysiloxane-15, Polysiloxane-16, Polysiloxane-17, Polysiloxane-18, Polysiloxane-19, Polysiloxane-20, Polysiloxane Polysiloxane-21, Polysiloxane-18 Hexadecyl Phosphate, Polysiloxane-1 Crosspolymer, Polysiloxane-18 Stearate, Polyurethane-10, Polydimethylsiloxane PEG-7 Potassium Panthenyl Phosphate, Polydimethylsiloxane PEG-7 Potassium Phosphate, PPG-12 Butyl Ether Polydimethylsiloxane, PPG-2 Polydimethylsiloxane, PPG-12 Polydimethylsiloxane, PPG-27 Polydimethylsiloxane, PPG-4 Oleth-10 polydimethylsiloxane, propoxytetramethylpiperidinyl polydimethylsiloxane, propyl polytrimethylsiloxane, quaternary ammonium salt-80, retinoxytrimethylsilane, silanediol salicylate, silanetriol, silanetriol arginine ester, silanetriol glutamate ester, silanetriol lysine ester, silanetriol melanin ester, silanetriol trehalose ether, silicon dioxide, silane polydimethylsiloxane silane ester, silane dimethylsiloxane silane ester, silicon carbide, polysiloxane quaternary ammonium salt-1, polysiloxane quaternary ammonium salt-2, polysiloxane quaternary ammonium salt-2 panthenol succinate, polysiloxane quaternary ammonium salt-3 Polysiloxane quaternary ammonium salt-4, polysiloxane quaternary ammonium salt-5, polysiloxane quaternary ammonium salt-6, polysiloxane quaternary ammonium salt-7, polysiloxane quaternary ammonium salt-8, polysiloxane quaternary ammonium salt-9, polysiloxane quaternary ammonium salt-10, polysiloxane quaternary ammonium salt-11, polysiloxane quaternary ammonium salt-12, polysiloxane quaternary ammonium salt-15, polysiloxane quaternary ammonium salt-16, polysiloxane quaternary ammonium salt-16 / glycidoxylated polydimethylsiloxane crosspolymer, polysiloxane quaternary ammonium salt-17, polysiloxane quaternary ammonium salt-18, polysiloxane quaternary ammonium salt-19, polysiloxane quaternary ammonium salt-20, polysiloxane quaternary ammonium salt-21.Polysiloxane Quaternary Ammonium Salt-22, Polysiloxane Quaternary Ammonium Salt-24, Polysiloxane Quaternary Ammonium Salt-25, Siloxane Triol Alginate, Siloxane Triol Phytate, Dimethyl Silicone Oil, Carboxydecyl PEG-8 Sodium Dimethyl Siloxane, Polydimethyl Siloxane PEG-7 Sodium Acetylmethyl Taurate, Sodium Dimethyl Silanol Hyaluronic Acid, Sodium Methyl Silanol Lactate, Sodium Methyl Silanol Mannuronic Acid, Sodium Methyl Silanol PCA, PG-Propyl Dimethyl Silicone Oil Sodium Thiosulfate Copolymer, PG-Propyl Thiosulfate Sodium Dimethyl Siloxane, Propoxy Hydroxypropyl Thiosulfate Sodium Silica, Sorbitol Silane Diol, Soybean Triethoxysilylpropyl Ammonium Dichloride, Stearane Dimethyl Siloxane PEG-8 Phthalate, Stearamidopropyl Dimethyl Siloxane Stearyl diammonium hydroxypropyl panthenyl PEG-7 polydimethylsiloxane phosphate chloride, stearyl diammonium hydroxypropyl PEG-7 polydimethylsiloxane phosphate chloride, stearyl oxy polydimethylsiloxane, stearyl oxy polydimethylsiloxane / polydimethylsiloxane copolymer, stearyl oxy trimethylsilane, stearyl aminopropyl methylsiloxane, stearyl polydimethylsiloxane, stearyl / laurate methacrylate crosspolymer, stearyl methylsiloxane, stearyl triethoxysilane, stearyl polytrimethylsiloxane, styrene / acrylate / polydimethylsiloxane acrylate crosspolymer, styrene / acrylate / polydimethylsiloxane copolymer, TEA-polydimethylsiloxane PEG-7 phosphate, tetrabutoxypropyltrisiloxane Tetramethylhexaphenyltetrasiloxane, Tetramethyltetraphenyltrisiloxane, Tocopheryloxypropyltrisiloxane, Tridecyl alcohol-9PG-aminopolydimethylsiloxane, Triethoxyoctylsilane, Triethoxysilylethylpolydimethylsiloxane / methylsiloxane copolymer, Triethoxysilylethylpolydimethylsiloxane, Triethoxysilylethylpolydimethylsiloxane, Triethoxysilylethylpolydimethylsiloxane, Triethoxysilylpropylcarbamoylethoxypropylbutylpolydimethylsiloxane, TrifluoromethylC1-4alkylpolydimethylsiloxane, Trifluoropropylcyclopentanesiloxane, Trifluoropropylcyclotetrasiloxane, Trifluoropropylpolydimethylsiloxane / PEG-1 0 crosslinked polymers, trifluoropropyl polydimethylsiloxane / trifluoropropyl divinyl polydimethylsiloxane crosslinked polymers, trifluoropropyl polydimethylsiloxane / vinyltrifluoropropyl, polydimethylsiloxane / silsesquioxane crosslinked polymers, trifluoropropyl polydimethylsiloxane alcohol, trifluoropropyl dimethyl / trimethylsiloxysilicate, trifluoropropyl methylsiloxane, trimethoxyoctylsilane, trimethoxysilyl polydimethylsiloxane, trimethylpentaphenyltrisiloxane, trimethylsiloxydimethylsiloxane, trimethylsiloxyphenyl polydimethylsiloxane, trimethylsiloxysilicate, trimethylsiloxysilicate / polydimethylsiloxane crosslinked polymers, trimethylsiloxysilicate / dimethylsiloxane alcohol crosslinked polymers,Trimethylsiloxysilylcarbamoyl branched starch, trimethylsilyl hydrolyzed shell protein PG-propylmethylsilanediol crosspolymer, trimethylsilyl hydrolyzed silk PG-propylmethylsilanediol crosspolymer, trimethylsilyl hydrolyzed wheat protein PG-propylmethylsilanediol crosspolymer, trimethylsilyl pullulan, trimethylsilyl glycolate trimethylsilyl ester, trimethylsilyl lactate trimethylsilyl ester, trimethylsilyl salicylate trimethylsilyl ester, triphenyl polytrimethylsiloxane, trisiloxane Tris-tributoxysiloxane, undecylpropenyl polydimethylsiloxane, vinyl polydimethylsiloxane, vinyl polydimethylsiloxane / lauryl polydimethylsiloxane crosspolymer, vinyl polydimethylsiloxane / methylsilsesquioxane crosspolymer, vinyl dimethyl / trimethylsiloxane stearyl polydimethylsiloxane crosspolymer, VP / polydimethylsiloxane acrylate / polycarbamoyl / polyethylene glycol ester, carboxydecyltrisiloxane zinc, polydimethylsiloxane PEG-8 zinc succinate, and mixtures thereof. More preferably, the siloxane to be included in the sunscreen composition or cosmetic composition according to the invention is polydimethylsiloxane, cyclopolymethylsiloxane, cyclopentylsiloxane, cyclotetrasiloxane, phenyl polytrimethylsiloxane, and cyclohexylsiloxane. The total amount of organosilicon compounds in the compositions according to the invention can vary, but is generally from 0.1% by weight to 20% by weight based on the total weight of the composition.
[0158] Dryness modifier: The sunscreen product, cosmetic, or pharmaceutical preparation of the present invention is preferably combined with a dryness modifier. A dryness modifier is a pharmaceutical agent that, when incorporated into an emulsion, imparts a "dry" feeling to the skin when the emulsion dries. The dryness modifier also reduces the migration of sunscreen agents on the skin. Dryness modifiers may include starch, talc, kaolin, chalk, zinc oxide, organosilicon fluids, inorganic salts such as barium sulfate and sodium chloride, C6 to C12 alcohols such as octanol; sulfonated oils; surface-treated silica, precipitated silica, pyrolytic silica (such as Aerosil purchased from Degussa Inc., New York, NY, USA). ® (or mixtures thereof); polydimethylsiloxane, a mixture of methylated linear siloxane polymers, is available under the trade name DC200 fluid from Dow Corning, Maryland, Michigan, USA. One or more dryness modifiers may optionally be included in the sunscreen agent in amounts from 0.01% to 20% by weight, more preferably from 0.1% to 10.0% by weight.
[0159] Skin moisturizing and / or moisturizing substances: Sunscreen products, cosmetics, or pharmaceutical preparations according to the invention advantageously contain one or more skin moisturizing and / or moisturizing substances. Preferred skin moisturizing and / or moisturizing substances are selected from the group consisting of alkyldiols or alkyltriols containing 3 to 12 carbon atoms, preferably C3-C10-alkyldiols and C3-C10-alkyltriols. More preferably, the skin moisturizer is selected from the group consisting of glycerin, 1,2-propanediol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol. Other skin moisturizing and / or hydrating substances include sodium lactate, urea, urea derivatives, alcohols, glycerin, glycols such as propylene glycol, hexanediol, collagen, elastin or hyaluronic acid, adipate diesters, petrolatum, urocanic acid, lecithin, panthenol, phytosterol, lycopene, (pseudo)ceramides, sphingolipids, cholesterol, phytosterols, deacetylated chitosan, chondroitin sulfate, lanolin, lanolin esters, amino acids, alpha-hydroxy acids (such as citric acid, lactic acid, malic acid) and their derivatives, monosaccharides, disaccharides and oligosaccharides such as glucose, galactose, fructose, mannose, fructose and lactose, polysaccharides such as R-glucan, especially 1,3-1,4-β-glucan from oats, alpha-hydroxy fatty acids, triterpenic acids such as betulinic acid or ursolic acid, and algal extracts.
[0160] Mildening agents: The sunscreen products, cosmetic or pharmaceutical preparations according to the invention may also advantageously contain one or more mildening agents, wherein any mildening agent suitable or conventional in cosmetic or pharmaceutical applications may be used, such as α-bisabolol, azulene, guaiac, 18-β-glycyrrhetinic acid, allantoin, aloe vera juice or gel, Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, chamomile, Arnica montana, Glycyrrhiza species, algae, seaweed and Calendula officinalis extracts, and plant oils such as sweet almond oil, lanolin, olive oil and panthenol, lauryl ether-9, tridecyl ether-9 and 4-tert-butylcyclohexanol.
[0161] Physiological cooling agents: Sunscreen products, cosmetic or pharmaceutical preparations according to the invention can be particularly advantageously combined with one or more physiological cooling agents. The use of cooling agents can relieve itching. Preferred individual cooling agents used within the scope of the invention are listed below. Those skilled in the art can add many other cooling agents to this list; the listed cooling agents can also be used in combination with each other, and these cooling agents are preferably selected from the following list: menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, isomenthol, neo-isomenthol), menthone ethers (e.g., (l-menthoxy)-1,2-propanediol, (l-menthoxy)-2-methyl-1,2-propanediol, l-menthyl-methyl ether), menthone glycerol acetal, menthone glycerol ketal or mixtures thereof, menthyl esters (e.g., menthyl formate, menthyl acetate, menthyl isobutyrate, menthyl hydroxyisobutyrate, menthyl lactate, etc.). L-menthyl-L-lactic acid ester, L-menthyl-D-lactic acid ester, menthyl-(2-methoxy)acetate, menthyl-(2-methoxyethoxy)acetate, menthyl pyroglutamic acid ester), menthyl carbonate (e.g., menthyl propylene glycol carbonate, menthyl ethylene glycol carbonate, menthyl glycerol carbonate, or mixtures thereof), half-esters of menthol with dicarboxylic acids or their derivatives (e.g., menthyl succinate, menthyl glutarate, menthyl malonic acid, O-menthyl succinate-N,N-(dimethyl)amide, O-menthyl succinate amide), menthane carboxylic acid amide (preferably menthane carboxylic acid-N-acetamide [WS3] or N... α-(menthanecarbonyl)glycidyl ester [WS5], menthanecarboxylic acid-N-(4-cyanophenyl)amide or menthanecarboxylic acid-N-(-4-cyanomethylphenyl)amide, menthanecarboxylic acid-N-(alkoxyalkyl)amide), menthone and menthone derivatives (e.g., L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2-propyl)-butyric acid-N-methylamide [WS23]), isoprene alcohol or its esters (l-(-)-isoprene alcohol, l-(-)-isoprene alcohol acetate), menthane derivatives (e.g., p-menthane-3,8-diol), piperidine alcohol or containing piperidine alcohol Synthetic or natural mixtures of citronellol, pyrrolidone derivatives of cycloalkyl dione derivatives (e.g., 3-methyl-2(1-pyrrolyl)-2-cyclopenten-1-one) or tetrahydropyrimidin-2-one (e.g., icilin or related compounds), additional formamides (e.g., N-(2-(pyridin-2-yl)ethyl)-3-p-menthaneformamide or related compounds), (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-isopropyl)cyclohexaneformamide [WS12], oxalates, and [(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]2-(ethylamino)-2-oxo-acetate (X Cool). Preferred coolants due to their special synergistic effects are l-menthol, d-menthol, racemic menthol, and menthone glycerol acetal (trade name: Frescolat). ® MGA), menthyl lactate (preferably l-lactic-menthyl lactate, especially l-lactic-menthyl lactate (trade name: Frescolat)). ® ML), substituted menthol-3-carboxamides (such as menthol-3-carboxylic acid N-ethylamide), 2-isopropyl-N-2,3-trimethylbutyramide, substituted cyclohexaneformamide, 3-menthoxypropane-1,2-diol, 2-hydroxyethylmenthyl carbonate, 2-hydroxypropylmenthyl carbonate, and isopreneol. Particularly preferred cooling agents are l-menthol, racemic menthol, and menthone glycerol acetal (trade name: Frescolat). ® MGA), menthyl lactate (preferably l-lactic-menthyl lactate, especially l-lactic-menthyl lactate (trade name: Frescolat)). ® ML), 3-menthoxypropane-1,2-diol, 2-hydroxyethylmenthyl carbonate, and 2-hydroxypropylmenthyl carbonate. Very particularly preferred cooling agents are 1-menthol, menthone glycerol acetal (trade name: Frescolat), and others. ® MGA) and menthyl lactate (preferably l-lactic-menthyl lactate, especially l-lactic-menthyl lactate (trade name: Frescolat)). ® ML).
[0162] Antioxidants: The sunscreen or cosmetic composition according to the invention advantageously comprises one or more antioxidants. Suitable antioxidants include amino acids (preferably glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (preferably phenylpropionic acid) and their derivatives, peptides (preferably D,L-carnosine, D-carnosine, L-carnosine and their derivatives (preferably chemoresine), carnitine, creatine, matrix factor peptides (preferably lysyl-threonyl-threonyl-lysyl-serine) and palmitoylated pentapeptides, carotenoids, carotenes (preferably α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and its derivatives (preferably dihydrolipoic acid), sulfur Glucose substitutes, propylthiouracil and other thiols (preferably thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, pentyl, butyl and lauryl, palmitoyl, oleyl, γ-linolenic acid, cholesterol, glyceryl and their oligoglycerides) and their salts, dilauryl thiodipropionate, dilauryl thiodipropionate, dilauryl thiodipropionate, thiodipropionic acid and their derivatives (preferably esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoxide compounds (preferably thionine sulfoxide, high-molecular-weight sulfoxide, etc.) Cystine sulfoxide, sulfone butylthionine, sulfone pentylenetine, sulfone hexathionine, sulfone heptathionine, sulfone heptathionine, and sulfone heptathionine, as well as (metal) chelating agents (preferably α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin, α-hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, tannins, bilirubin, biliverdin, EDTA, EGTA and their derivatives), unsaturated fatty acids and their derivatives (preferably γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and its derivatives, panthenol and its derivatives, vitamin C and its derivatives (preferably...) The selected substances include ascorbyl palmitate, Mg phosphate ascorbate, acetate ascorbate, ascorbyl glucoside, tocopherol and its derivatives (preferably vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), and coniferyl benzoate, rutin and its derivatives, flavonoids and their glycosylated precursors, especially quercetin and its derivatives, preferably α-glucosylrutin, rosmarinic acid, caryophyllene, caryophyllene acid, resveratrol, caffeic acid and its derivatives, sinapic acid and its derivatives, ferulic acid and its derivatives, curcuminoids, chlorogenic acid and its derivatives, and visual pigments.Preferred active ingredients include retinyl palmitate, retinol or retinoic acid, ursolic acid, acetylpropionic acid, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiacol, nordihydroguaiacol, trihydroxybutanone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (preferably ZnO, ZnSO4), selenium and its derivatives (preferably selenomethionine), superoxide dismutase, stilbene and its derivatives (preferably stilbene oxide, trans-stilbene oxide), and derivatives (salts) of these referenced active ingredients suitable according to the present invention. Extracts or fractions of plants with antioxidant effects, preferably green tea, red tea tree, honey shrub, grape, rosemary, sage, lemon balm, thyme, lavender, olive, oat, cocoa, ginkgo, ginseng, licorice, honeysuckle, sophora japonica, kudzu root, pine, citrus, amla or St. John's wort, grape seed, wheat germ, amla, coenzyme, preferably coenzyme Q10, plastoquinone, menadione, and octanoyloxyphenylaminodimethyltetrahydrobenzothiazide carboxylic acid. Preferred antioxidants are selected from the group consisting of: vitamin A and its derivatives, vitamin C and its derivatives, tocopherol and its derivatives (preferably tocopherol acetate), and ubiquinone.
[0163] Emulsifiers: Furthermore, the sunscreen compositions or cosmetic compositions of the present invention may advantageously contain one or more emulsifiers to maintain the stability of the sunscreen compositions or cosmetic compositions. Emulsifiers include amphoteric, anionic, cationic, or nonionic emulsifiers, which may be used alone or in mixtures. The emulsifier is selected in a suitable manner according to the emulsion to be obtained. Preferred examples include: - Add 2 mol to 30 mol of ethylene oxide and / or 0 mol to 5 mol of propylene oxide to the straight-chain C 8-22 fatty alcohols, C 12-22 Products on fatty acids and alkylphenols containing 8 to 15 carbon atoms; - The C of the product obtained by adding 1 mol to 30 mol of ethylene oxide to glycerol 12 / 18 Fatty acid monoesters and diesters; - Glyceryl monoesters and diesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms, sorbitol monoesters and diesters, and their ethylene oxide addition products; - Products obtained by adding 15 mol to 60 mol of ethylene oxide to castor oil and / or hydrogenated castor oil; - Polyol esters, and especially polyglycerol esters, such as, for example, polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate, or polyglycerol dimethyl isostearate. Mixtures of compounds from several of these categories are also suitable; - Products obtained by adding 2 mol to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil; -Based on straight chain, branched chain, unsaturated or saturated C 6 / 22 Fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g., sorbitol), alkyl glucosides (e.g., methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g., cellulose); - Monoalkyl phosphates, dialkyl phosphates and trialkyl phosphates and monoPEG-alkyl phosphates, diPEG-alkyl phosphates and / or triPEG-alkyl phosphates and their salts; - Lanolin; - Polysiloxane / polyalkyl polyether copolymers and corresponding derivatives; - A mixture of pentaerythritol, fatty acids, citric acid, and fatty alcohols and / or C 6-22 A mixed ester of fatty acids, methyl glucose, and polyols, preferably glycerol or polyglycerol. - Polyalkylene glycol, - Glyceryl carbonate, - Glyceryl oleate citrate - Caprylic / Capric triglycerides - Hydrogenated palm glycerol ester.
[0164] The products of the addition of ethylene oxide and / or propylene oxide to fatty alcohols, fatty acids, alkylphenols, glycerol monoesters and diesters of fatty acids, and sorbitol monoesters and diesters, or to castor oil, are known and commercially available. They are homologues, and their average degree of alkoxylation corresponds to the ratio between the amount of ethylene oxide and / or propylene oxide and the amount of substrate undergoing the addition reaction. The C10 of the products of the addition of ethylene oxide to glycerol is... 12 / 18 Fatty acid monoesters and diesters are known as lipid layer enhancers in cosmetic formulations.
[0165] The preferred emulsifiers are described in more detail below: Metaglycerides: Typical examples of suitable metaglycerides are glyceryl monohydroxystearate, diglyceryl hydroxystearate, glyceryl isostearate, diglyceryl isostearate, glyceryl monooleate, diglyceryl oleate, glyceryl castor oil, diglyceryl castor oil, glyceryl linoleate, diglyceryl linoleate, glyceryl linolenic acid, diglyceryl linolenic acid, glyceryl monolinolenic acid, diglyceryl linolenic acid, glyceryl monoernate, diglyceryl ernate, glyceryl tartrate, diglyceryl tartrate, glyceryl citrate, diglyceryl citrate, glyceryl malate, diglyceryl malate, and industrial mixtures thereof, which may still contain trace amounts of triglycerides from the production process. Products obtained by adding 1 mol to 30 mol, preferably 5 mol to 10 mol, of ethylene oxide to the above metaglycerides are also suitable.
[0166] Sorbitol esters: Suitable sorbitol esters include sorbitol monoisostearate, sorbitol sesquiisostearate, sorbitol diisostearate, sorbitol triisostearate, sorbitol monooleate, sorbitol sesquioleate, sorbitol dioleate, sorbitol trioleate, sorbitol monoerucic acid ester, sorbitol hemierucic acid ester, sorbitol glyceryl dierucic acid ester, sorbitol monoricinoleate, sorbitol sesquiricinoleate, sorbitol diricinoleate, sorbitol triricinoleate, and sorbitol monoricinoleate. Sorbitol monohydroxy stearate, sorbitol sesquihydroxy stearate, sorbitol dihydroxy stearate, sorbitol trihydroxy stearate, sorbitol monotartrate, sorbitol sesquitartrate, sorbitol ditartrate, sorbitol tritartrate, sorbitol monocitrate, sorbitol sesquicitrate, sorbitol dicitrate, sorbitol tricitrate, sorbitol monomaleate, sorbitol sesquimaleate, sorbitol dimaleate, sorbitol trimaleate, and technical mixtures thereof. The products obtained by adding 1 mol to 30 mol, preferably 5 mol to 10 mol, of ethylene oxide to the above-mentioned sorbitol esters are also suitable.
[0167] Polyglycerol esters: A typical example of a suitable polyglycerol ester is polyglycerol-2-dimeric hydroxystearate (Dehymuls). ® PGPH), polyglycerol-3 diisostearate (Lameform) ® TGI), polyglycerol-4 isostearate (Isolan) ® GI 34), polyglycerol-3 oleate, diisostearoyl polyglycerol-3 diisostearoate (Isolan) ® PDI), polyglycerol-3-methylglucose distearate (Tego Care) ® 450), polyglycerol-3 beeswax (Cera Bellina) ® ), polyglycerol-4-decanoate (polyglycerol decanoate T2010 / 90), polyglycerol-3-hexadecyl ether (Chimexane) ® NL), polyglycerol-3 distearate (Cremophor) ® GS 32) and polyglycerol polyricinoleate (Admul) ®WOL 1403), polyglycerol dimethyl ether isostearate, and mixtures thereof. Other suitable examples of polyol esters are monoesters, diesters, and trimers of trimethylolpropane or pentaerythritol with lauric acid, coconut fatty acids, tallow fatty acids, palmitic acid, stearic acid, oleic acid, behenic acid, etc., optionally reacted with 1 mol to 30 mol of ethylene oxide.
[0168] Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12-C22 fatty acids, such as palmitic acid, stearic acid or benzolic acid, and C12-C22 dicarboxylic acids, such as azelaic acid or sebacic acid.
[0169] Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric or zwitterionic surfactants. Amphoteric surfactants are surface-active compounds containing at least one quaternary ammonium group and at least one carboxyl group and one sulfonate group in their molecules. Particularly suitable amphoteric surfactants are so-called betaines, such as N-alkyl-N,N-dimethylglycinine ammonium, for example, cocoalkyldimethylglycinine ammonium; N-acylaminopropyl-N,N-dimethylglycinine ammonium, for example, cocoylaminopropyldimethylglycinine ammonium; and 2-alkyl-3-carboxymethyl-3-hydroxyethylimidazoline and cocoylaminoethylhydroxyethylcarboxymethylglycinate esters containing 8 to 18 carbon atoms in the alkyl or acyl group. Fatty acid amide derivatives known as cocoylaminopropyl betaine under the name CTFA are particularly preferred. Amphoteric surfactants are also suitable emulsifiers. 8 / 18 Surfactant compounds containing at least one free amino group and at least one COOH- or -SO3H- group in addition to the alkyl or acyl group, and capable of forming an inner salt. Examples of suitable amphoteric surfactants are N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamidepropylglycine, N-alkyltaurine, N-alkylsarcosine, 2-alkylaminopropionic acid, and alkylaminoacetic acid, which contain about 8 to 18 carbon atoms in the alkyl group. Particularly preferred amphoteric surfactants are N-cocoyl alkylaminopropionate, cocoylaminoethylaminopropionate, and C... 12 / 18 Acylsarcosine.
[0170] Suitable emulsifiers include, for example, cetyl polydimethylsiloxane copolyols (e.g., Abil EM-90), polyglycerol-2-dipolyhydroxy stearate (e.g., Dehymuls PGPH), polyglycerol-3-diisostearate (e.g., Lameform TGI), polyglycerol-4-isostearate (e.g., Isolan GI 34), polyglycerol-3-oleate (e.g., Isolan GO 33), diisostearoyl polyglycerol-3-diisostearate (e.g., Isolan PDI), polyglycerol-3-methylglucose distearate (e.g., Tego Care 450), polyglycerol-3-beeswax (e.g., Cera Beilina), polyglycerol-4-decanoate (e.g., polyglycerol decanoate T2010 / 90), polyglycerol-3-cetyl ether (e.g., Chimexane NL), and polyglycerol-3-distearate (e.g., Cremophor GS). 32) and polyglycerol polyricinoleate (e.g., AdmulWOL 1403), glyceryl oleate (e.g., Monomuls 90-O 18), alkyl glucoside (e.g., Plantacare 1200, EmulgadePL 68 / 50, Montanov 68, Tego Care CG 90, Tego GlucosidL 55), methyl glucosyl isostearate (e.g., Tego Care IS), methyl glucosyl sesquistearate (Tego Care PS), cocoyl hydrolyzed malt protein sodium salt (e.g., GluadinWK), cetyl phosphate potassium (e.g., Amphisol K, Crodafos CKP, Emulsiphos F), alkyl sulfate sodium salt (e.g., Lanette E), sucrose ester (e.g., Crodesta F-10, F-20, F-50, F-70, F-110, F-160, SL-40, Emulgade ®Sucro), ethoxylated and / or propoxylated fatty alcohols, fatty acids, castor oil and hydrogenated castor oil (e.g., Eumulgin B2, B2, B3, L, HRE 40, HRE 60, RO 40, Cremophor HRE 40, HRE 60, L, WO 7, Dehymuls HRE 7, Arlacel 989), PEG-30 dihydroxystearate (e.g., Arlacel P135, Dehymuls LE), sorbitol esters, ethoxylated and / or propoxylated sorbitol esters, and mixtures thereof. Particularly effective mixtures consist of polyglycerol-2 dihydroxystearate and lauryl glucoside and glycerol (e.g., Eumulgin VL 75). Also suitable are polyglycerol-4 diisostearate / polyhydroxystearate / sebacic acid ester (Isolan... ® GPS), diisostearoyl polyglycerol-3 diisostearoyl ester (e.g., Isolan PDI), and alkali metal salts of acyl glutamate (e.g., Eumulgin SG).
[0171] In a preferred embodiment, at least one emollient is selected from a mixture of C16-18 monoglycerides, diglycerides, and triglycerides, more preferably from glyceryl oleate citrate, caprylic / capric triglycerides (such as Drocorin). ® GOC) and glyceryl stearate citrate (such as Drocorin) ® (CE). Other preferred C16-18 monoglycerides, diglycerides, and triglycerides include glyceryl stearate, glyceryl palmitate, glyceryl oleate, glyceryl linoleate, glyceryl dioleate, glyceryl distearate, and glyceryl trioleate.
[0172] Antimicrobial agents: The sunscreen compositions or cosmetic compositions according to the invention can be advantageously combined with antimicrobial agents that act primarily on microorganisms, particularly bacteria, yeasts and / or fungi, and include one or more antimicrobial agents such as 1,2-decanediol (decanediol), 1,2-heptanediol, 1,2-hexanediol, 1,2-nonanediol, 1,2-octanediol, 1,2-pentanediol, 1,2-propanediol, 1,3-propanediol, 2,3-decanediol, 2,3-heptanediol, 2,3-hexanediol, 2,3-nonanediol, 2,3-octanediol, 2,3-pentanediol, 2-benzylheptanol, 2-hydroxyacetophenone, 2-methyl5-cyclohexylpentanol, 3-hydroxypropyl decanoate, 3-hydroxypropyl dodecanoate, 3-hydroxypropyl 2-hydroxybenzoate, 4-hydroxyacetophenone, alkyl (C 12-22) Trimethylammonium bromide and ammonium chloride, anisic acid and its salts, 3-hydroxypropyl anisic acid, ascorbic acid and its salts, ascorbate palmitate, azelaic acid, azeloyl diglycine ester, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharin, benzyl chloride, benzoic acid, 3-hydroxypropyl benzoate, benzyl alcohol, benzyl salicylate, benzothiazolinone, bisabolol, bromonorphine (2-bromo-2-nitropropane-1,3-Diol), Butylene Glycol, Butyl Paraben, Camphor, Capryloyl Hydroxamic Acid, Capryloyl Glycine, Capryloyl / Hexanoyl Dehydromethyl Glucoamide, Capryloyl Glyceryl Ether, Capryloyl / Capric Triglyceride, Hexadecyl Pyridine Chloride, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Chlorocresol, Chloroxenol, Chlorphenesin Glycerin, Citronellol Methyl Crotonate, Clomidazole, Cyclohexylglycerin, Dehydroacetic Acid, Diazoalkyl Urea, Dimethylphenyl Butanol, Dimethylphenyl Propanol, Dipropylene Glycol, Disodium EDTA, DM DM hydantoin, ethanol, ethyl lauroyl arginine ester HCl, ethyl lauroyl arginine ester laurate, ethylhexylglycerin, ethylparaben, eucalyptol, farnesol, mangosteen fruit peel extract, gluconate and its salts, glycerin, glyceryl caprylate, glyceryl caprylate, glyceryl heptaate, glyceryl laurate, glyceryl undecenoate, glycolipid, heptaglycerin, hexamidine, hexamidine dihydroxyethyl sulfonate, hexanediol, hexylglycerin, hydroxyethoxyphenylbutanol, hydroxyethoxyphenylbutanone, imidazolidinyl urea, iodopropynyl butylcarbamate, isoamyl laurate, isobutyl p-hydroxybenzoate Isopropylparaben, itaconic acid and its salts, jasmol, lactic acid, lauryl alcohol, acetylpropionic acid, mandelic acid, mannitol, menthol, methyl salicylate, methyl undecanoate, methylbenzyl alcohol, methylchloroisothiazolinone, methylheptylglycerol, methylisothiazolinone, methylparaben and its salts, methylpropylene glycol, Morinda officinalis callus culture lysate, oxytinib HCl, octylisothiazolinone, o-cymene-5-ol, panthenol, PCA cocoyl arginine ethyl ester, phenethyl alcohol, phenoxyethanol, phenylpropanol, piroctone ketone ethanolamine, polyarginine, polyglycerol-10 laurate Polyglycerol-2-decanoate, polyglycerol-3-octanoate, polyglycerol-4-octanoate / decanoate, polyglycerol-4-laurate / sebate, polylysine, potassium sorbate, propylene glycol decanoate, propylene glycol octanoate, propylene glycol laurate, propylene glycol undecenoate, propylene glycol, propylene glycol octanoate, propylparaben, raspberry ketone, glycoisomers, salicylic acid, sage (sage) oil, silver chloride, silver citrate, sodium anisinate, sodium benzoate, sodium decanoyl lactylate, sodium hexanoyl / lauroyl lactylate, sodium ethylparaben, sodium lactate, sodium lauroyl lactylate, levulinic acid Sodium, levulinic acid, sodium methylparaben, sodium phytate, phytic acid, sodium propylparaben, sorbic acid, sorbitan decanoate, sorbitol, TEA-salicylic acid ester, algae extract, tetrasodium diglutamate diacetate, thymol, triclocarban, triclosan, triethyl citrate, trisodium dicarboxymethylalanine, trisodium ethylenediaminedisuccinate, tolphenone, undecenoic acid, undecenoyl glycine, xylitol octanoate, xylitol sesquioctanoate, zinc citrate, zinc lactate, zinc neodecanoate, zinc pyrithione, zinc ricinoleate, and octanoyl / hexanoyl dehydromethylglucosamide, and mixtures thereof.
[0173] To further enhance antimicrobial efficacy, sunscreen compositions or cosmetic compositions, as defined herein, are advantageously combined with at least one additional antimicrobial agent different from the antimicrobial agents described above. Combination with an additional antimicrobial agent provides reliable protection against microbial degradation and deterioration of the formulation, particularly during storage. In addition, other different antimicrobial agents provide reliable protection against other microorganisms as described above, such as Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Malassezia, Peptoniphilus, Streptococcus, Lactobacillus, Gardnerella, Fannyhessea, Epidermophyton, Trichophyton, and Cutibacterium. Therefore, combinations with other different antimicrobial agents allow for antimicrobial protection against different groups of microorganisms, and thus allow for a wider range of microorganisms.In the context of this invention, other different antimicrobial agents are preferably selected from the group consisting of: 2-benzylheptanol, alkyl (C 12-22)trimethylammonium bromide and ammonium chloride, ascorbic acid and its salts, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharin, benzyl chloride, benzoic acid, camphor, hexadecylpyridine chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol, cyclohexylglycerol, dimethylphenylbutanol, dimethylphenylpropanol, ethanol, lauroyl arginine ethyl ester HCl, lauroyl arginine ethyl ester laurate, eucalyptol, gluconic acid and its salts, glycerol, hexamidine, hexamidine dihydroxyethyl sulfonate. Diisethionate, hexylglycerin, iodopropynyl butylcarbamate, jasmol, lauryl alcohol, levulinic acid and its esters and / or ketals, mannitol, menthol, methyl salicylate, octinidin HCl, polyarginine, polyglycerol-10 lauryl ester, polyglycerol-2 decanoate, polyglycerol-3 caprylate, polylysine, medicinal sage (sage) oil, silver chloride, silver citrate, sodium hexanoyl lactylate, sodium hexanoyl / lauroyl lactylate, sodium lauroyl lactylate, sorbic acid, sorbitol, plankton extract, triclocarban, triclosan, triethyl citrate, xylose sesquiocrylate, zinc citrate, zinc pyrithione, zinc ricinoleate, and any mixtures thereof.
[0174] The aforementioned antimicrobial agents are used as a single component in sunscreen compositions or cosmetic compositions, or preferably in combination with two or more antimicrobial agents as specified above. Based on the total weight of the final formulation, the antimicrobial agent is present in the sunscreen composition or cosmetic composition in an amount of 0.01% to 25.0% by weight, preferably 0.02% to 15.0% by weight, and most preferably 0.05% to 6.0% by weight.
[0175] Preservatives: For preservation purposes, the sunscreen compositions or cosmetic compositions of the present invention preferably contain one or more preservatives that are suitable for or commonly used in sunscreen compositions or cosmetic compositions.Suitable and beneficial preservatives include benzoic acid, sodium benzoate, ammonium benzoate, butyl benzoate, hydroxypropyl benzoate, calcium benzoate, MEA benzoate, isobutyl benzoate, isopropyl benzoate, magnesium benzoate, tetrabutyl benzoate, methyl benzoate, phenyl benzoate, potassium benzoate, propyl benzoate, propionic acid, ammonium propionate, calcium propionate, magnesium propionate, potassium propionate, sodium propionate, salicylic acid, calcium salicate, magnesium salicate, salicylates, sodium salicylate, TEA salicylate, sorbic acid, calcium sorbate, sodium sorbate, potassium sorbate, o-phenylphenol, sodium sulfite, ammonium bisulfite, potassium bisulfite, and potassium bisulfite. Hydrogensulfite), sodium bisulfite, sodium metabisulfite, potassium metabisulfite, chlorobutanol, 4-hydroxybenzoic acid, methylparaben, potassium ethylparaben, potassium paraben, sodium methylparaben, sodium ethylparaben, sodium ethylparaben, sodium paraben, potassium methylparaben, calcium paraben, butylparaben, propylparaben, sodium propylparaben, sodium butylparaben, potassium butylparaben, potassium propylparaben, dehydroacetic acid, dehydrogenated methylparaben Sodium acetate, formic acid, sodium formate, dibromohexamidine hydroxyethyl sulfonate, thimerosal, phenylmercuric acetate, phenylmercuric benzoate, undecenoic acid, potassium undecenoate, sodium undecenoate, calcium undecenoate, undecenoic acid MEA salt, undecenoic acid TEA salt, hexocide, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, dichlorobenzyl alcohol, triclocarban, p-chloro-m-cresol, triclosan, chloroxylenol, imidazolidinyl urea Polyurethane; Biguanide, Phenoxyethanol, Methenamine, Clomid, DMDM Hydantoin, Benzyl Alcohol, 1-Hydroxy-4-Methyl-6-(2,4,4-Trimethylpentyl)-2-Pyridone, Piroctone ethanolamine, Bromochlorofen, o-Cymene-5-ol, Methylchloroisothiazolinone and Methylisothiazolinone, Chlorhexidine, Chlorhexidine diacetate, Chlorhexidine digluconate, Chlorhexidine dihydrochloride, Phenoxyisothiazolinone Propanol, behenyltrimethylammonium chloride (1), cetrimonium bromide, cetrimonium chloride (2), lauryltrimethylammonium bromide, lauryltrimethylammonium chloride, stearyltrimethylammonium bromide, stearyltrimethylammonium chloride (2), dimethyloxazoline, diazolidinyl urea, hexamidine, hexamidine dihydroxyethyl sulfonate, hexamidine dihydroxybenzoate, hexamidine paraben, glutaraldehyde, 7-ethylbicyclooxazoline, chlorophenoxyacetate, sodium hydroxymethylglycinate, silver chloride, benzyl chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharin ammonium, formaldehyde benzyl alcohol hemiacetal, iodopropynyl butylcarbamate, methylisothiazolinone, citric acid, silver citrate, hydroxyethoxyphenyl butyl ketone (HEPB), and any mixture thereof.
[0176] Pharmaceuticals: The sunscreen composition or cosmetic composition according to the present invention is preferably combined with one or more pharmaceuticals. In some such embodiments, the pharmaceutically active agent is selected from the group consisting of: anti-acne agents, agents for treating rosacea, analgesics, anesthetics, appetite suppressants, antihistamines, anti-inflammatory agents (including nonsteroidal anti-inflammatory drugs), antibiotics, antifungals, antiviral agents, antimicrobial agents, anticancer active ingredients, scabicides, lice-killing agents, antitumor drugs, antiperspirants, antipruritics, antipsoriatic agents, antiseborrheic agents, bioactive proteins and peptides, burn treatment agents, cauterizing agents, bleaching agents, depilatory agents, diaper rash treatment agents, enzymes, hair growth stimulants, hair growth depressants (including efornithine and its salts and analogues), hemostatic agents, keratolytic agents, and cankersore treatment agents. Treatment agents, cold sore treatment agents, dental and periodontal treatment agents, photosensitizing active substances, skin protectants / barrier agents, steroids (including hormones and corticosteroids), sunburn treatment agents, sunscreens, transdermal active ingredients, nasal active ingredients, vaginal active ingredients, wart treatment agents, wound treatment agents, wound healing agents, etc.
[0177] Particularly useful are mixtures of natural or naturally occurring anti-inflammatory substances, especially extracts or fractions from chamomile, aloe, myrrh species, madder species, willow, willowherb, oats, calendula, arnica, St. John's wort, honeysuckle, rosemary, pink passionflower, witch hazel, ginger, or echinacea; selected from the group consisting of: extracts or fractions from chamomile, aloe, oats, calendula, arnica, honeysuckle, rosemary, witch hazel, ginger, or echinacea, and / or pure substances, preferably α-bisabolol, apigenin, apigenin-7-glucoside, gingerols, shogaols, gingereneols, gingeroglycol, dehydrogingerols. Diketones, paradols, natural or naturally occurring alanine anthracene amides, preferably tranilast, alanine anthracene A, alanine anthracene B, alanine anthracene C, non-natural or non-natural alanine anthracene amides, preferably dihydroalanine anthracene D, dihydroalanine anthracene E, alanine anthracene D, alanine anthracene E, alanine anthracene F, boswellic acid, phytosterols, glycyrrhizin, glycyrrhizin and glycyrrhizin chalcone A; selected from the group consisting of: α-bisabolol, natural alanine anthracene amides, non-natural alanine anthracene amides, preferably dihydroalanine anthracene D (such as WO The ingredients include, as described in 2004 047833A1, boswellic acid, phytosterols, glycyrrhizin and glycyrrhizin chalcone A, and / or allantoin, panthenol, lanolin, (pseudo)ceramides [preferably ceramide 2, hydroxypropyl bispalmitamide MEA, hexadecyloxypropylglyceromethoxypropyltetradecanoamide, N-(1-hexadecyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethylpalmitoyloxyhydroxypropylpalmitamide], glycosphingolipids, phytosterols, chitosan, mannose, lactose and β-glucan, especially 1,3->1,4β-glucan from oats.
[0178] In addition to the substances mentioned above, other ingredients commonly used in sunscreen compositions or cosmetic compositions may be used, which are suitable or conventional in the compositions of the present invention.
[0179] The sunscreen compositions or cosmetic compositions of the present invention are intended for topical application. The term "topical" should be understood to mean external application to the skin or mucous membranes of mammals, particularly for the protection, treatment, care, and cleansing of skin, scalp, eyelashes, eyebrows, fingernails / toenails, mucous membranes, and hair. Mammals are preferably humans.
[0180] For topical application, cosmetics are either rinse-off or no-rinse formulations.
[0181] The sunscreen products according to the present invention can be in the form of aqueous solutions, dispersions, aqueous alcohol carriers, rods, ointments, gels, aerosols (foams, sprays, propulsion pumps), etc.
[0182] According to the first aspect of the invention, the sunscreen composition or cosmetic composition, particularly dermatological preparations or home care products according to the invention, may exist in different forms, for example, as a dispersion, as an anhydrous formulation, or as an aqueous solution, aqueous / alcoholic solution, particularly an aqueous / ethanolic solution, aqueous / glycolic acid solution, or alcoholic / glycolic acid solution, particularly an ethanolic / glycolic acid solution.
[0183] In a preferred embodiment, the sunscreen composition or cosmetic composition according to the invention is a dispersion. In the context of this invention, the term "dispersion" means a two-phase system consisting of colloidal particles (dispersed phase) and a medium in which the colloidal particles are suspended (dispersion medium). The two phases are immiscible with each other and miscible only with emulsifiers. Such dispersions, such as emulsions, contain preferably ≥1% by weight, more preferably ≥3% by weight, at least one oil component (free of UV filters).
[0184] Preferably, the sunscreen composition or cosmetic composition according to the invention takes various forms, such as emulsions, especially O / W emulsions, W / O emulsions, multiple emulsions, water-dispersible gels, balms, water-in-oil (W / O / WO) or oil-in-water (O / W / O) multiple emulsions, PIT emulsions, Pickering emulsions, microemulsions, liquids, lotions, suspensions, milks, ointments, pastes, gels, cream-based, oil-based or liposome-based formulations, or aerosols (such as foams and sprays), including all types of silicone-based emulsions.
[0185] In the most preferred embodiment, the sunscreen composition or cosmetic composition according to the invention is in emulsion form as defined herein, advantageously in oil-in-water (O / W) emulsion form, which contains an oil phase dispersed in an aqueous phase in the presence of an O / W or polymeric emulsifier.
[0186] If the sunscreen composition or cosmetic composition according to the invention is a dispersion, preferably an emulsion, then the oil component (excluding UV filters) is present in the cosmetic or pharmaceutical formulation in an amount from 0.01% by weight to 50.0% by weight, based on the total weight of the composition. In a preferred embodiment, the cosmetic or pharmaceutical formulation contains an amount from 0.1% by weight to 45.0% by weight of the oil component, based on the total weight of the composition. In a particularly preferred embodiment, the oil component is advantageously used in the cosmetic or pharmaceutical formulation in an amount from 1.0% by weight to 40% by weight, based on the total weight of the composition.
[0187] In another embodiment, the sunscreen or cosmetic product according to the invention is an anhydrous formulation, i.e., an oil formulation.
[0188] If the sunscreen composition or cosmetic composition according to the invention is an anhydrous formulation, i.e. an oil formulation, then based on the total weight of the composition, the oil component is present in the cosmetic or pharmaceutical preparation in an amount of ≥60% by weight, preferably ≥75% by weight, more preferably ≥90% by weight.
[0189] Such anhydrous formulations include, for example, oils, skin creams, powders, lipsticks, antiperspirants / deodorants, and decorative cosmetics.
[0190] In addition, other anhydrous formulations are also based on ethanol / diol / triol / ethylene glycol, such as sprays or gels.
[0191] Alternatively, the sunscreen or cosmetic composition disclosed herein may be an aqueous solution or an aqueous / alcoholic solution, preferably an aqueous / ethanolic solution, or an aqueous / glycolic acid solution, or an alcoholic / glycolic acid solution, preferably an ethanolic / glycolic acid solution. Typically, this may be glycerin in an aqueous or alcoholic composition. The solution is a homogeneous single-phase system of water / alcohol / ethylene glycol and other components. Solutions based on water / alcohol, water / glycolic acid, or alcohol / glycolic acid contain, based on the total weight of the solution, an amount from 0.1 wt% to 70.0 wt%, preferably 0.5 wt% to 60.0 wt%, more preferably 1.0 wt% to 50.0 wt% of an aliphatic alcohol or ethylene glycol. The aliphatic alcohol is preferably selected from the group consisting of ethanol, isopropanol, and n-propanol. Ethylene glycol is preferably selected from the group consisting of: glycerol, propylene glycol, 1,3-propanediol, 1,2-propanediol, 1,2-C5 to C10 alkyl diols, butanediol or dipropylene glycol.
[0192] Preferably, the total water content in the final water-based solution can be ≥30% by weight, more preferably ≥40% by weight, and most preferably ≥50% by weight.
[0193] Such solutions based on water or water / alcohol or water / glycolic acid or alcohol / glycolic acid include, for example, deodorant / antiperspirant preparations, aftershave, cleansing preparations, or anti-acne preparations.
[0194] In a preferred embodiment, the composition of the present invention is an impregnation solution in the form of an emulsion spray or an ethanol / oil spray for use with wet wipes.
[0195] The above-mentioned formulations or compositions are prepared according to conventional and known methods.
[0196] The products and formulations according to the present invention are intended for use in cosmetics and / or non-therapeutic purposes, for personal care, particularly for skin care, skin protection, sun protection, scalp protection, scalp care, hair care, finger / toenail care, and especially for the prevention and treatment of skin conditions, intolerance or sensitive skin, skin irritation, skin redness, urticaria, pruritus (itching), skin aging, wrinkle formation, loss of skin volume, loss of skin elasticity, pigmentation spots, abnormal pigmentation, dry skin, peeling, oily skin, hypopigmentation and / or hyperpigmentation; or for use in animal care.
[0197] Examples of cosmetic compositions preferably include anti-aging agents, skin lotions, body oils, body emulsions, cleansing lotions, facial or body balms, aftershave balms, aftersunscreen balms, deodorant lotions, cationic emulsions, body gels, treatment creams, skin-protecting ointments, moisturizing gels, facial and / or body moisturizers, photoprotective agents (sunscreens), micellar water, hairspray, color-protecting hair care products, skin brightening products, and anti-darkening repair products.
[0198] The cosmetic composition also includes cosmetics, eye care preparations, eyeshadow, mascara, eyeliner, lip care preparations such as lipstick, lip gloss, and nail care preparations such as nail polish and nail polish remover.
[0199] Other examples of cosmetic compositions include BB cream (concealer or balm), CC cream (color corrector), tinted moisturizer, primer, hairspray, foundation, makeup, bronzer, lipstick, after-sun gel, cooling spray, serum, scalp protectant spray, scalp serum, hair oil, leave-in hair treatment, body spray, and cleansing oil with UV protection.
[0200] For use, the sunscreen composition or cosmetic composition according to the invention is applied in sufficient quantity to the skin, hair, scalp and / or fingernails / toenails in a conventional manner.
[0201] The liquid UV filter concentrate of this invention can also be incorporated into home care products to prevent sunlight-induced degradation, fading, and material damage. Specifically, the UV filter concentrate imparts UV protection to surfaces, thereby helping to maintain the appearance, structural integrity, and lifespan of treated surfaces. This protection is particularly valuable in products designed to clean, treat, or coat surfaces exposed to sunlight, including wood, furniture, textiles, automotive interiors, glass, and outdoor equipment. By integrating UV filters into home care formulations, these products provide additional protective benefits beyond cleaning and conditioning, thereby enhancing product performance and maintaining the quality of treated materials over time. Examples of household care products include surface cleaners, disinfectant wipes, kitchen cleaners, bathroom cleaners, glass cleaners, stainless steel polishers, liquid detergents, powder detergents, fabric softeners, laundry accelerators, stain removers, antibacterial laundry treatments, hand dishwashing liquids, automatic dishwasher detergents, rinsing aids, dishwashing accelerators, room fresheners, fabric fresheners, odor neutralizers, rattan diffusers, air fresheners, wood polishes and protectants, leather conditioners, carpet and furniture upholstery cleaners, floor cleaners, furniture protective coatings, UV-protective window treatments, anti-fog glass treatments, self-cleaning glass coatings, car wash and wax solutions, tire and trim protectants, UV-protective dashboard treatments, outdoor furniture protectants, patio and deck cleaners, shoe and leather protectants, antistatic treatments, UV-protective textile treatments, insect-repellent fabric treatments, and pet-safe UV-protective treatments.
[0202] The liquid UV filter concentrate of the present invention can also be incorporated into personal care products. Examples of personal care products include shampoos, conditioners, hair bleaching agents, dry shampoo, hair growth oils, hair strengthening treatments, hair smoothers, shower gels, body washes, soap bars, liquid hand soaps, exfoliating body scrubs, bath oils, bath foams, bath salts, bath bombs, toothpaste, mouthwash, dental floss, teeth whitening kits, breath freshening sprays, feminine washes, feminine wipes, deodorants, hand soaps, antibacterial hand gels, cuticle oils, foot creams, foot sprays, foot soaks, roll-on deodorants, stick deodorants, spray deodorants, crystal deodorants, shaving foams, shaving gels, pre-shaving oils, post-shaving cooling gels, beard oils, beard balms, beard shampoo, baby shampoo, baby wash, baby oil, baby powder, baby wipes, antibacterial body washes, medicated cleansing sticks, sulfur soaps, coal tar soaps, and acne-prone body washes.
[0203] Based on the total weight of the cosmetic composition, the liquid UV filter concentrate of the present invention is incorporated into the cosmetic composition in an amount of ≥0.001 wt% to ≤2.0 wt%, preferably ≥0.01 wt% to ≤0.75 wt%, more preferably ≥0.1 wt% to ≤0.5 wt%. Based on the total weight of the personal care product, the liquid UV filter concentrate of the present invention is incorporated into the personal care product in an amount of ≥0.001 wt% to ≤2.0 wt%, preferably ≥0.01 wt% to ≤0.75 wt%, more preferably ≥0.1 wt% to ≤0.5 wt%. Based on the total weight of the home care product, the liquid UV filter concentrate of the present invention is incorporated into the home care product in an amount of ≥0.001 wt% to ≤2.0 wt%, preferably ≥0.01 wt% to ≤0.75 wt%, more preferably ≥0.1 wt% to ≤0.5 wt%.
[0204] The invention is further illustrated below with at least a few embodiments, but it is not intended to limit the invention to the specific embodiments listed below.
[0205] Implementation Plan : 1. A UV filter concentrate that is a liquid at room temperature, said UV filter concentrate comprising... (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b) At least two different oil-soluble organic UV filters, UV2 and UV3, comprising ≥40% by weight to ≤97% by weight, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤130°C. (c) at least one diol, ranging from ≥0.1% by weight to ≤6.0% by weight; The weight percentage is based on the total weight of the UV filter concentrate.
[0206] 2. The UV filter concentrate according to embodiment 1, wherein, based on the total weight of the UV filter concentrate, the UV filter concentrate contains an amount ranging from ≥50% by weight to ≤88% by weight, preferably from ≥60% by weight to ≤85% by weight, and more preferably from ≥70% by weight to ≤85% by weight of the at least two different oil-soluble organic UV filters, UV2 and UV3.
[0207] 3. The UV filter concentrate according to embodiment 1 or 2, wherein the UV filter concentrate has a viscosity in the range of ≥2000 mPa.s to ≤25000 mPa.s at 20°C, as determined by Brookfield DV-III with a rotor CP51 at 2.0 rpm.
[0208] 4. The method according to any one of embodiments 1 to 3, wherein the at least one oil-soluble organic UV filter UV1, which is liquid at room temperature, is selected from the group consisting of: humosafil, octyl cyanobenzyl acrylate, 2-ethylhexyl methoxycinnamate, 2-ethylhexyl salicylate, polyacrylamide methylbenzyl camphor, menthyl anthranilate, dimethyl PABA 2-ethylhexyl, TEA-salicylate, polysiloxane-15, and isoamyl p-methoxycinnamate.
[0209] 5. The UV filter concentrate according to any one of embodiments 1 to 4, wherein, based on the total weight of the UV filter concentrate, component (a) is present in an amount ranging from ≥5% by weight to ≤60% by weight, preferably from ≥10% by weight to ≤50% by weight, more preferably from ≥12% by weight to ≤40% by weight, and even more preferably from ≥15% by weight to ≤30% by weight.
[0210] 6. The UV filter concentrate according to any one of embodiments 1 to 5, wherein the at least two different oil-soluble organic UV filters, UV2 and UV3, are selected from the group consisting of: diethylhexylbutamidotriazinone, benzophenone-3, cresoltrazol trisiloxane, 4-methylbenzyl camphor, diethylaminohydroxybenzoylhexyl benzoate, benzophenone-8, butylmethoxydibenzoylmethane, diethylhexyloxyphenol methoxyphenyltriazine, methoxypropylaminocyclohexeneide ethoxyethyl cyanoacetate, and ethylhexylethylhexyltriazinone.
[0211] 7. The UV filter concentrate according to any one of embodiments 1 to 6, wherein the organic oil-soluble UV filter UV2 comprises at least one organic UV filter UV2a and at least one organic UV filter UV2b, wherein the organic oil-soluble UV filter UV2a has a melting point MP2a in the range of ≥30°C to ≤70°C, and the organic oil-soluble UV filter UV2b has a melting point MP2b in the range of ≥71°C to ≤100°C.
[0212] 8. The UV filter concentrate according to embodiment 7, wherein the at least one organic UV filter UV2a is selected from the group consisting of: benzophenone-3,4-methylbenzyl camphor, diethylaminohydroxybenzoylhexyl benzoate and benzophenone-8.
[0213] 9. The UV filter concentrate according to embodiment 7, wherein the at least one organic UV filter UV2b is selected from the group consisting of: butyl methoxydibenzoylmethane, diethylhexylbutamidotriazine, bis(ethylhexyloxyphenol)methoxyphenyltriazine, cresoltrazol trisiloxane, and methoxypropylaminocyclohexeneylethoxyethyl cyanoacetate.
[0214] 10. The UV filter concentrate according to any one of embodiments 1 to 9, wherein the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥101°C to ≤130°C.
[0215] 11. The UV filter concentrate according to embodiment 10, wherein the organic oil-soluble UV filter UV3 is ethylhexyltriazine ketone.
[0216] 12. The UV filter concentrate according to any one of embodiments 1 to 11, wherein the ratio of the sum of the weight percentages of the at least two different oil-soluble organic UV filters UV2 and UV3 to the weight percentage of at least one oil-soluble organic UV filter UV1 is in the range of ≥3.0:1.0 to ≤20.0:1.0, preferably in the range of ≥4.0:1.0 to ≤7.0:1.0, wherein the weight percentages are based on the total weight of the UV filter concentrate.
[0217] 13. The UV filter concentrate according to any one of embodiments 1 to 12, wherein the at least one diol (c) is an unsubstituted alkane diol having a straight or branched chain having 5 to 12 carbon atoms. 14. The UV filter concentrate according to any one of embodiments 1 to 13, wherein the at least one diol (c) is an unsubstituted ortho-alkane diol having a straight or branched chain with 5 to 12 carbon atoms.
[0218] 15. The UV filter concentrate according to embodiment 14, wherein the unsubstituted ortho-alkanediol having 5 to 12 carbon atoms in the straight or branched chain is selected from the group consisting of: 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and 2,3-dodecanediol.
[0219] 16. The UV filter concentrate according to any one of embodiments 1 to 15, wherein, based on the total weight of the UV filter concentrate, component (c) is present in an amount ranging from ≥0.5% by weight to ≤6.0% by weight, preferably from ≥1.0% by weight to ≤6.0% by weight, and more preferably from ≥1.5% by weight to ≤6.0% by weight.
[0220] 17. The UV filter concentrate according to any one of embodiments 1 to 16, wherein the UV filter concentrate further comprises at least one oil (d).
[0221] 18. The UV filter concentrate according to embodiment 17, wherein the at least one oil (d) is selected from the group consisting of: Guerbert alcohol based on a fatty alcohol having 6 to 18 carbon atoms, straight-chain C6-C 22 - Fatty acids and straight-chain or branched C6-C 22 -Ester or branched C6-C fatty alcohols 13 -Carboxylic acids with straight-chain or branched C6-C 22 -Ester of fatty alcohols, straight-chain C6-C 22 -Esters of fatty acids and branched alcohols, straight-chain or branched C2-C 10 Diols with straight-chain or branched C6-C 22 - Fatty acid esters, C 18 -C 38 -alkyl hydroxycarboxylic acids with straight-chain or branched C6-C 22 - Esters of fatty alcohols and / or C2-C5 alcohols, esters of straight-chain or branched fatty acids with polyols and / or gerbert alcohols, based on C6-C 10 - Triglycerides of fatty acids, based on C6-C 18 - A liquid mixture of monoglycerides / diglycerides / triglycerides of fatty acids, C6-C 22 - Esters of fatty alcohols and / or gerberis alcohols with aromatic carboxylic acids, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, straight-chain and branched C6-C... 22 - Fatty alcohol carbonates, based on guerbert carbonates of fatty alcohols having 6 to 18 carbon atoms, benzoic acid with straight-chain and / or branched C6-C... 22 -Esters of alcohols, straight-chain or branched, symmetrical or asymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group, ring-opening products of epoxidized fatty acid esters with polyols, aliphatic hydrocarbons or cycloalkanes, ring-opening products of fatty acid esters with polyols, aliphatic hydrocarbons or cycloalkanes, by addition of 2 mol to 30 mol of ethylene oxide and / or 0 mol to 5 mol of propylene oxide to a straight-chain C-chain.8-22 Addition to C4 of fatty alcohols 12-22 The C-values of products added to fatty acids and to alkylphenols containing 8 to 15 carbon atoms in the alkyl group, and the C-values of addition products of 1 to 30 mol of ethylene oxide to glycerol. 12 / 18 Fatty acid monoesters and diesters, glycerol monoesters, diesters and triesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms, as well as dehydrated sorbitol monoesters and diesters and their ethylene oxide addition products, addition products of 15 mol to 60 mol of ethylene oxide to castor oil and / or hydrogenated castor oil, addition products of 2 mol to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil, petrolatum, squalane, squalene, isohexadecane, dialkylcyclohexane, based on straight-chain, branched, unsaturated or saturated C 6 / 22 Esters and metaesters of fatty acids, ricinoleic acid and 12-hydroxystearic acid, and dialkyl ethers of glycerol, polyglycerol, pentaerythritol, dipentaerythritol and isosorbide.
[0222] 19. The UV filter concentrate according to embodiment 18, wherein the at least one oil (d) is selected from the group consisting of: linear or branched C2-C 10 Diols with straight-chain or branched C6-C 22 - Fatty acid esters, C 18 -C 38 -alkyl hydroxycarboxylic acids with straight-chain or branched C6-C 22 - Esters of fatty alcohols and / or C2-C5 alcohols, C2-C 12 - Dicarboxylic acids and esters of straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; benzoic acid and straight-chain and / or branched C6-C... 22 - Esters of alcohols, and fatty acid esters of polyols, aliphatic hydrocarbons, or cycloalkanes, based on straight-chain, branched-chain, unsaturated, or saturated C464. 6 / 22 The monoglycerides, diglycerides, and triglycerides of fatty acids, ricinoleic acid, and 12-hydroxystearic acid, as well as metaesters, and alkyl ethers of glycerol, polyglycerol, pentaerythritol, dipentaerythritol, and isosorbide.
[0223] 20. The UV filter concentrate according to embodiment 18 or 19, wherein the at least one oil (d) is selected from the group consisting of: ethylhexyl acetoxystearate, propylene glycol dioctanoate, propylene glycol octanoate, diethylhexyl 2,6-naphthalenedicarboxylate, diisopropyl adipate, and octanoic acid / decanoic acid triglyceride.
[0224] 21. The UV filter concentrate according to embodiment 17, wherein the at least one oil (d) is a fatty acid ester selected from the group consisting of: C 12-C 15 Alkyl benzoate, Caprylic / Capric triglyceride, Caprylic / Capric / Lauryl triglyceride, Caprylic / Capric / Linoleic triglyceride, Caprylic / Capric / Myristic acid / Stearic triglyceride, Caprylic / Capric / Palmitic acid / Stearic triglyceride, Caprylic / Capric / Stearic triglyceride, Caprylic / Capric / Succinic triglyceride, Caprylic octyl acetate, Cetearyl ethylhexanoate, Cetearyl isononanoate, Cetearyl nonanoate, Coconut caprylate, Coconut Decyl oleate, Decyl oleate, Dioctyl carbonate, Diethyl succinate, Diethylhexyl 2,6-naphthalenedicarboxylate, Diethylhexyl carbonate, Dibutyl adipate, Diisopropyl adipate, Dipropylheptyl carbonate, Ethyl laurate, Ethylhexyl isononanoate, Ethylhexyl palmitate, Ethylhexyl stearate, Ethylhexyl acetoxystearate, Caprylic / Capric glyceride, Caprylic / Capric glyceride, Caprylic / Capric glyceride, Triacetylhydroxystearate, Triacetyl Castor oil glyceryl ester, hexyl laurate, isoamyl acetate, isoamyl coconut oil ester, isopropyl palmitate, isosorbide dicaprylate, isopropyl myristate, myristyl myristate, oleic acid / linoleic acid triglycerides, oleic acid / palmitic acid triglycerides, oleic acid / palmitic acid / lauric acid / myristic acid / linoleic acid triglycerides, propylene glycol caprylate, castor oil / caproic acid / capric acid / capric acid triglycerides, stearyl oleate, erucic acid oleate, palmitic acid / stearic acid glycerides Triglycerides, propylene glycol dicaprylate, propyl heptyl caprylate, stearyl heptate / stearyl caprylate, triheptyl glycerol, trihydroxystearin, triisononyl, triisopalmitin, glyceryl triisostearate, trilaurylate, trilinoleic acid trioleate, trilinolein, trimyristate, trioleic acid trioleate, tripalmitin, trinonanoic acid trioleate, triricinoleic acid trioleate, and tristearate, as well as dimethyl isosorbide.
[0225] 22. The UV filter concentrate according to any one of embodiments 1 to 21, wherein, based on the total weight of the UV filter concentrate, the at least one oil (d) is present in an amount ranging from ≥10.0% by weight to ≤50% by weight, preferably from ≥20% by weight to ≤45% by weight.
[0226] 23. The UV filter concentrate according to any one of embodiments 1 to 22, wherein the UV filter concentrate does not contain any oil-soluble organic UV filter in its crystalline form.
[0227] 24. The UV filter concentrate according to any one of embodiments 1 to 23, wherein the UV filter concentrate comprises (a) At least one oil-soluble organic UV filter, UV1, which is liquid at room temperature. (b1) At least one organic oil-soluble UV filter UV2a, having a melting point MP2a in the range of ≥30°C to ≤70°C. (b2) At least one organic oil-soluble UV filter, UV2b, having a melting point MP2b in the range of ≥71°C to ≤100°C. (b3) At least one organic oil-soluble UV filter, UV3, having a melting point MP3 in the range of ≥101°C to ≤130°C. (c) At least one diol.
[0228] 25. The UV filter concentrate according to embodiment 24, wherein component (a) is 2-ethylhexyl salicylate, component (b1) is diethylaminohydroxybenzoylhexyl benzoate, component (b2) is bisethylhexyloxyphenol methoxyphenyl triazine, and component (b3) is ethylhexyl triazine ketone.
[0229] 26. The UV filter concentrate according to embodiment 24, wherein the component (c) is selected from the group consisting of: 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, ethylhexyl acetoxystearate, propylene glycol dioctanoate, propylene glycol octanoate, diethylhexyl 2,6-naphthalenedicarboxylate, diisopropyl adipate, and octanoic / decanoic triglycerides.
[0230] 27. The UV filter concentrate according to any one of embodiments 24 to 26, wherein said component (a) is present in an amount ranging from ≥10.0% by weight to ≤30% by weight, preferably in an amount ranging from ≥10.0% by weight to ≤20% by weight. The component (b1) is present in an amount ranging from ≥20% by weight to ≤45% by weight, preferably in an amount ranging from ≥20.0% by weight to ≤35% by weight. The component (b2) is present in an amount ranging from ≥20% by weight to ≤45% by weight, preferably in an amount ranging from ≥20.0% by weight to ≤35% by weight. The component (b3) is present in an amount ranging from ≥10.0 wt% to ≤30 wt%, preferably in an amount ranging from ≥10.0 wt% to ≤20 wt%. The component (c) is present in an amount ranging from ≥1.0 wt% to ≤6.0 wt%.
[0231] 28. A method for preparing a UV filter concentrate that is a liquid at room temperature according to any one of embodiments 1 to 27, said method comprising at least the following steps: (A) Heating at least one oil-soluble organic UV filter UV1, which is liquid at room temperature, to a temperature T1 in the range of ≥40°C to ≤75°C to obtain a heated solution; (B) At a temperature T2 in the range of ≥50°C to ≤130°C, the heated solution of step (A) is mixed with at least two different oil-soluble organic UV filters, UV2 and UV3, to obtain a heated mixture, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of ≥30°C to ≤130°C, and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of ≥30°C to ≤130°C; (C) The heated mixture from step (B) is kept at temperature T3 to obtain a UV filter concentrate; During step (C), the at least one diol (c) is added; and The temperature T3 is in the range of ≥20°C to ≤70°C lower than the highest melting point of the at least two different oil-soluble organic UV filters, UV2 and UV3.
[0232] 29. A sunscreen composition, cosmetic composition, or home care composition comprising at least one UV filter concentrate according to any one of embodiments 1 to 27.
[0233] 30. The sunscreen composition, cosmetic composition, or home care composition according to embodiment 29, wherein the sunscreen composition, cosmetic composition, or home care composition further comprises at least one inorganic UV filter.
[0234] 31. The sunscreen composition, cosmetic composition, or home care composition according to embodiment 29 or 30, wherein the sunscreen composition, cosmetic composition, or home care composition further comprises at least one antimicrobial agent.
[0235] 32. The sunscreen composition, cosmetic composition, or home care composition according to any one of embodiments 29 to 31, wherein the sunscreen composition, cosmetic composition, or home care composition further comprises at least one excipient and / or cosmetic or pharmaceutical active substance selected from the group consisting of: carriers, oil components, rheology modifiers, water-soluble growth promoters, solubilizers, powders, film-forming agents, water resistance improvers, skin moisturizing and / or water-retaining substances, soothing substances, physiological coolants, antioxidants, anti-skin aging agents, matrix metalloproteinase inhibitors (MMPI), anti-inflammatory agents, TRPV1 antagonists, emulsifiers, preservatives, antibacterial or antifungal active substances, chelating agents, surfactants, fragrances / perfumes or fragrance oils, and any mixture of two or more of the above substances.
[0236] 33. A sunscreen composition, cosmetic composition, or home care composition according to any one of embodiments 29 to 32, wherein the sunscreen composition, cosmetic composition, or home care composition is used as a cosmetic for personal care. Example
[0237] The invention is described in detail through the following non-limiting working examples.
[0238] Example 1a: Preparation method of UV filter concentrate UV filter concentrate FC1a having the following composition as a percentage by weight based on the total weight of the composition is prepared by the method described below.
[0239] While stirring, heat ethylhexyl salicylate to 60°C. Add diethylaminohydroxybenzoylhexyl benzoate and heat the resulting mixture to 80°C with stirring. Maintain the mixture at this temperature until it becomes clear. Add diethylhexyloxyphenol methoxyphenyl triazine and heat the resulting mixture to 95°C with stirring. Maintain the mixture at this temperature until it becomes clear. Add ethylhexyl triazine ketone and heat the resulting mixture to 120°C with stirring. Maintain the mixture at 120°C for 30 minutes. When the mixture becomes clear, cool it to 100°C. Add octanediol and stir at this temperature for 240 minutes. Allow the resulting mixture to cool for 24 hours.
[0240] A clear liquid was obtained. The mixture contained no crystals. The viscosity of the mixture at 30°C was 4168 mPa·s, as determined by Brookfield DV-III with a CP51 rotor at 2.0 rpm.
[0241] The mixture was stored in a sealed container at room temperature for 3 months and still no crystals were observed.
[0242] Example 1b: Method for preparing UV filter concentrate outside the scope of the present invention .
[0243] UV filter concentrate FC1b, which is outside the scope of the present invention, is prepared by the method described below and has the following composition as a percentage by weight based on the total weight of the composition.
[0244] While stirring, heat ethylhexyl salicylate to 60°C. Add diethylaminohydroxybenzoylhexyl benzoate and heat the resulting mixture to 80°C with stirring. Maintain the mixture at this temperature until it becomes clear. Add diethylhexyloxyphenol methoxyphenyl triazine and heat the resulting mixture to 95°C with stirring. Maintain the mixture at this temperature until it becomes clear. Add ethylhexyl triazine ketone and heat the resulting mixture to 120°C with stirring. Maintain the mixture at 120°C for 30 minutes. When the mixture becomes clear, cool it to 100°C and stir at this temperature for 240 minutes. Allow the resulting mixture to cool for 24 hours.
[0245] A clear liquid with a slightly yellow hue was obtained. The mixture contained no crystals. The viscosity of the mixture at 30°C was 6793 mPa·s, as determined by Brookfield DV-III with a CP51 rotor at 2.0 rpm.
[0246] The mixture was stored in a sealed container at room temperature for 3 months and still no crystals were observed.
[0247] Example 2 : The following UV filter concentrates FC2, having the following composition by weight percentage based on the total weight of the composition, were prepared by the method described in Example 1. Each UV filter concentrate FC2a, FC2c, and FC2e to FC2i existed as a clear liquid with a slightly yellow tint. The mixture contained no crystals. UV filter concentrates FC2b and FC2d did contain crystals.
[0248] Example FC2c shows that octanediol is most effective in reducing viscosity, i.e., only a relatively small amount of the compound causes a significant reduction in viscosity (13230 mPa.s at 20°C and 4272 mPa.s at 30°C, compared to 6793 mPa.s at 30°C for similar composition FC1b).
[0249] *Outside the scope of this invention The use of butanediol and pentanediol results in a slightly cloudy liquid.
[0250] Example 3: Addition of ethyl cellulose The following UV filter concentrate FC2, having the following composition by weight percentage based on the total weight of the composition, was prepared by the method described in Example 2, except that Antaron was heated at a temperature of 100°C. ™ Eco is added to ethylhexyl salicylate, and then the temperature is maintained at 120°C to 130°C.
[0251] Example 4: Cold-in-cold manufacturing of sunscreen composition The UV filter concentrate FC2f of the present invention is effectively incorporated into a uniform sunscreen composition in a wide range of different amounts through a conventional cold-in-cold manufacturing process.
[0252] Example 5: Cold, medium, and hot manufacturing of sunscreen compositions The UV filter concentrate FC2f of the present invention is effectively incorporated into a uniform sunscreen composition in a wide range of different amounts through conventional cold, medium and hot manufacturing processes.
[0253] Example 6: Sunscreen Oil Experiment SPF 30 Example 7: Sunscreen Spray Experiment SPF 50+ / 50 Example 8: Sunscreen stick with inorganic UV filter SPF 50 test Example 9: Transparent sunscreen stick experiment SPF 50+ Example 10: Cold-to-Cold Sunscreen Formulation (A, B, C, D, E) Example 11: Sunscreen cream (W / O); SPF 40 Composition of Fragrance Oil 1 (PO1; amount per ‰ by weight) Composition of Fragrance Oil 2 (PO2; amount per ‰ by weight) Composition of Fragrance Oil 3 (PO3; amount per ‰ by weight) Composition of Fragrance Oil 4 (PO4; amount per ‰ by weight) Composition of spice oil 5 (PO5; amount per ‰ by weight) Example 12: Transparent Liquid Hand Sanitizer Example 13: Soap bar Example 14: Silver Shampoo Color
Claims
1. A UV filter concentrate which is liquid at room temperature, comprising (a) at least one oil-soluble organic UV filter UV1 which is liquid at room temperature, (b) > 40 wt.% to < 97 wt.% of at least two different oil-soluble organic UV filters UV2 and UV3, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of > 30 °C to < 130 °C and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of > 30 °C to < 135 °C, and (c) > 0.1 wt.% to < 6.0 wt.% of at least one glycol; wherein the weight percentages are based on the total weight of the UV filter concentrate.
2. The UV filter concentrate according to claim 1, wherein the UV filter concentrate comprises the at least two different oil-soluble organic UV filters UV2 and UV3 in an amount in the range of > 50 wt.% to < 88 wt.%, preferably in an amount in the range of > 60 wt.% to < 85 wt.%, more preferably in an amount in the range of > 70 wt.% to < 85 wt.%, based on the total weight of the UV filter concentrate.
3. The UV filter concentrate according to claim 1 or 2, wherein the UV filter concentrate has a viscosity in the range of > 2000 mPa.s to < 25000 mPa.s at 20 °C determined according to Brookfield DV-III with spindle CP51 at 2.0 rpm.
4. The UV filter concentrate according to any one of claims 1 to 3, wherein the at least one oil-soluble organic UV filter UV1 which is liquid at room temperature is selected from the group consisting of homosalate, octocrylene, 2-ethylhexyl methoxy cinnamate, 2-ethylhexyl salicylate, polyacrylamidomethyl benzylidene camphor, menthyl anthranilate, 2-ethylhexyl dimethyl PABA, TEA-salicylate, polysilicone-15 and isoamyl p-methoxy cinnamate.
5. The UV filter concentrate according to any one of claims 1 to 4, wherein component (a) is present in an amount in the range of > 5 wt.% to < 60 wt.%, preferably in the range of > 10 wt.% to < 50 wt.%, more preferably in the range of > 12 wt.% to < 40 wt.%, more preferably in the range of > 15 wt.% to < 30 wt.%, based on the total weight of the UV filter concentrate.
6. The UV filter concentrate according to any one of claims 1 to 5, wherein the organic oil-soluble UV filter UV2 comprises at least one organic UV filter UV2a and at least one organic UV filter UV2b, wherein the organic oil-soluble UV filter UV2a has a melting point MP2a in the range of > 30 °C to < 70 °C and the organic oil-soluble UV filter UV2b has a melting point MP2b in the range of > 71 °C to < 100 °C.
7. The UV filter concentrate according to any one of claims 1 to 6, wherein the oil-soluble organic UV filter UV3 has a melting point MP3 in the range of > 101 °C to < 135 °C.
8. The UV filter concentrate according to any one of claims 1 to 7, wherein the at least one diol (c) is a linear or branched, unsubstituted vicinal alkanediol having 5 to 12 carbon atoms, preferably 6 to 12 carbon atoms.
9. The UV filter concentrate according to claim 8, wherein the linear or branched, unsubstituted vicinal alkanediol having 5 to 12 carbon atoms is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and 2,3-dodecanediol.
10. The UV filter concentrate according to any one of claims 1 to 9, wherein component (c) is present in an amount in the range of > 0.5 wt.-% to < 6.0 wt.-%, preferably in the range of > 1.0 wt.-% to < 6.0 wt.-%, more preferably in the range of > 1.5 wt.-% to < 6.0 wt.-%, based on the total weight of the UV filter concentrate.
11. The UV filter concentrate according to any one of claims 1 to 10, further comprising at least one alkyl cellulose, preferably ethyl cellulose.
12. The UV filter concentrate according to any one of claims 1 to 11, wherein the UV filter concentrate is free of any oil-soluble organic UV filter in its crystalline form.
13. The UV filter concentrate according to any one of claims 1 to 12, wherein the UV filter concentrate comprises (a) at least one oil-soluble organic UV filter UV1 being liquid at room temperature, (b1) at least one organic oil-soluble UV filter UV2a having a melting point MP2a in the range of > 30 °C to < 70 °C, (b2) at least one organic oil-soluble UV filter UV2b having a melting point MP2b in the range of > 71 °C to < 100 °C, (b3) at least one organic oil-soluble UV filter UV3 having a melting point MP3 in the range of > 101 °C to < 135 °C, (c) at least one diol, preferably a linear or branched, unsubstituted alkanediol having 5 to 12 carbon atoms, preferably 6 to 12 carbon atoms.
14. A process for preparing a UV filter concentrate being liquid at room temperature according to any one of claims 1 to 13, the process comprising at least the following steps: (A) heating at least one oil-soluble organic UV filter UV1 being liquid at room temperature to a temperature T1 in the range of > 40 °C to < 75 °C to obtain a heated solution; (B) mixing the heated solution of step (A) with at least two different oil-soluble organic UV filters UV2 and UV3 at a temperature T2 in the range of > 50 °C to < 135 °C to obtain a heated mixture, wherein the organic oil-soluble UV filter UV2 has a melting point MP2 in the range of > 30 °C to < 130 °C and the organic oil-soluble UV filter UV3 has a melting point MP3 in the range of > 30 °C to < 135 °C; (C) keeping the heated mixture of step (B) at a temperature T3 to obtain a UV filter concentrate; wherein the at least one diol (c) is added during step (C); and the temperature T3 is in the range of > 20 °C to < 70 °C below the highest melting point of the at least two different oil-soluble organic UV filters UV2 and UV3.
15. A sunscreen composition or a cosmetic composition or a home care composition comprising at least one UV filter concentrate according to any one of claims 1 to 14.
16. The sunscreen composition or cosmetic composition or household care composition according to claim 15, wherein the composition further comprises at least one UV filter selected from the group consisting of 2-ethylhexyl salicylate, ethylhexyl triazone, butyl methoxydibenzoylmethane, terephthalylidene dicamphor sulfonic acid and salts, 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid hexyl ester, menthyl anthranilate, 2,2'-(1,4-phenylene)bis-[1 H-benzimidazole-4,5-disulfonic acid] disodium salt, methoxypropylaminocyclohexenylidenyl ethoxyethyl cyanoacetate, octocrylene, homosalate, octyl salicylate, 2-ethylhexyl-p-dimethylaminobenzoate, triethanolamine salicylate, 2-ethylhexyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-phenylbenzimidazole sulfonic acid and salts thereof, 3-(4'-methylbenzylidene)-d,l-camphor, 4,4'-[(6-[4-(1,1-dimethyl)aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)imino]bis(benzoic acid 2-ethylhexyl ester), malonic acid benzylidene ester-polysiloxane, 4,4',4''-(1,3,5-triazine-2,4,6-triyl triimino)tris(2-ethylhexyl)tris-benzoate, bis- ethylhexyloxyphenol methoxyphenyl triazine, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, 2-hydroxy-4-methoxybenzophenone, phenol, -(2H-benzotriazol-2-yl-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1- (trimethylsilyl)oxy)disiloxanyl)propyl), 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-1,1,3,3- tetramethylbutyl)-phenol, tris- biphenyl triazine and 5,6,5',6'-tetraphenyl-3,3'-(1,4-phenylene)bis(1,2,4-triazine).
17. The sunscreen composition or cosmetic composition or household care composition according to claim 15, wherein the composition further comprises at least one additional active ingredient selected from the group consisting of: a) a sunscreen agent, b) a skin lightening agent, c) a skin soothing agent, d) a skin protectant, e) a skin conditioning agent, f) a skin moisturizing agent, g) a skin exfoliating agent, h) a skin cleansing agent, i) a skin conditioning agent, j) a skin moisturizing agent, k) a skin exfoliating agent, 1) a skin cleansing agent, m) a skin conditioning agent, n) a skin moisturizing agent, o) a skin exfoliating agent, p) a skin cleansing agent, q) a skin conditioning agent, r) a skin moisturizing agent, s) a skin exfoliating agent, t) a skin cleansing agent, u) a skin conditioning agent, v) a skin moisturizing agent, w) a skin exfoliating agent, x) a skin cleansing agent, y) a skin conditioning agent, z) a skin moisturizing agent, aa) a skin exfoliating agent, bb) a skin cleansing agent, cc) a skin conditioning agent, dd) a skin moisturizing agent, ee) a skin exfoliating agent, ff) a skin cleansing agent, gg) a skin conditioning agent, hh) a skin moisturizing agent, ii) a skin exfoliating agent, jj) a skin cleansing agent, kk) a skin conditioning agent, 11) a skin moisturizing agent, mm) a skin exfoliating agent, nn) a skin cleansing agent, oo) a skin conditioning agent, pp) a skin moisturizing agent, qq) a skin exfoliating agent, rr) a skin cleansing agent, ss) a skin conditioning agent, tt) a skin moisturizing agent, uu) a skin exfoliating agent, vv) a skin cleansing agent, ww) a skin conditioning agent, xx) a skin moisturizing agent, yy) a skin exfoliating agent, zz) a skin cleansing agent, aaa) a skin conditioning agent, bbb) a skin moisturizing agent, ccc) a skin exfoliating agent, and ddd) a skin cleansing agent.
Citation Information
Patent Citations
Anthranilic acid amides and the derivatives thereof as cosmetic and pharmaceutical agents
WO2004047833A2
