Skin care composition with blue light protection efficacy and use thereof

Abstract

The present application relates to the technical field of cosmetics, in particular to a skin care composition with blue light protection efficacy and application thereof, the skin care composition comprises tetrahydro methyl pyrimidine carboxylic acid, troxerutin, red ginger extract and cocoa seed extract, the composition obtained by compounding the above raw materials can reduce the generation of ROS triggered by light damage, reduce the content of melanin and red pigment in the skin under blue light irradiation, has significant blue light protection efficacy, and is mild and non-irritating.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetic technology, in particular to a skin care composition with blue light protection efficacy and application thereof. BACKGROUND

[0002] With the popularity of electronic devices and the widespread use of artificial light sources, blue light radiation with a wavelength of 400-500 nm has become one of the main non-ionizing radiation sources in modern society. Studies have shown that blue light radiation can penetrate the dermis of the skin and cause a series of skin damage reactions through photo-oxidation. The main mechanism of action is as follows: after the blue light energy is absorbed by skin cells, it causes mitochondrial electron transport chain dysfunction, inducing excessive generation of reactive oxygen species (ROS); excessive ROS attacks cell membrane lipids, proteins and DNA, triggering a chain of damage reactions such as lipid peroxidation, protein carbonylation and DNA strand breakage; long-term accumulation of oxidative stress further activates matrix metalloproteinases (MMPs), accelerating the degradation of collagen and elastic fibers, leading to skin photoaging, pigmentation and barrier function impairment.

[0003] Currently, the cosmetic technology for UV protection is relatively mature, but the research on blue light protection is still in its infancy. In the prior art, blue light protection is mainly achieved through physical shielding or the addition of a single antioxidant ingredient, which has the following technical bottlenecks: first, relying solely on physical barriers cannot fully cover the visible light band, and affects the product usage texture; second, a single antioxidant ingredient cannot cope with the complex oxidative damage network induced by blue light, resulting in low protection efficiency and poor timeliness. Therefore, developing a blue light protection composition with multi-target synergistic effect has become a technical problem to be solved in the field of cosmetics. SUMMARY

[0004] To achieve the above-mentioned purpose and overcome the deficiencies of the prior art, the present application provides a skin care composition with blue light protection efficacy and application thereof.

[0005] In a first aspect, the present application provides a skin care composition with blue light protection efficacy, which comprises the following mass parts of raw materials:

[0006] tetrahydro methyl pyrimidine carboxylic acid: 0.5-4 parts;

[0007] troxerutin: 0.5-4 parts;

[0008] red ginger extract: 0.1-0.5 parts;

[0009] cocoa seed extract: 0.1-0.5 parts.

[0010] Among them:

[0011] Tetrahydro-methylpyrimidine carboxylic acid can prevent blue light-induced protein denaturation by binding to proteins, maintain the integrity of the skin's physical barrier. In addition, it can also induce heat shock protein expression, help damaged cells recover, enhance cell tolerance to light damage, while reducing ROS production.

[0012] Troxerutin, as a flavonoid derivative, can protect cell membrane lipids by providing hydrogen atoms to scavenge ROS, while stabilizing vascular endothelial cell membranes and reducing microcirculation disorders caused by blue light.

[0013] The red ginger extract is rich in active substances such as gingerols, polysaccharides, and flavonoids. Gingerols and others can increase the expression of antioxidant enzymes and establish cell antioxidant reserves in advance; polysaccharide components can promote the synthesis of ceramides and strengthen the skin barrier; flavonoids can synergistically scavenge ROS and reduce epidermal cell apoptosis caused by blue light.

[0014] Cocoa seed extract is rich in proanthocyanidins and flavonoids, focusing on "antioxidant + anti-inflammatory". Blue light exposure can exacerbate skin oxidative damage and inflammatory response. The antioxidant activity of cocoa seed can reduce the accumulation of free radicals, thereby assisting in resisting indirect damage from blue light. In addition, cocoa seed extract can also down-regulate the activity of matrix metalloproteinases (MMPs), reduce the decomposition of collagen type I caused by blue light, and promote the proliferation of fibroblasts to maintain the structure of the dermal layer.

[0015] The present application has found that the combination of the above-mentioned raw materials can achieve excellent blue light protection efficacy through synergistic effect.

[0016] Preferably, the skin care composition comprises the following mass parts of raw materials:

[0017] Tetrahydro-methylpyrimidine carboxylic acid: 2 parts;

[0018] Troxerutin: 3 parts;

[0019] Red ginger extract: 0.4 parts;

[0020] Cocoa seed extract: 0.3 parts.

[0021] In a second aspect, the present application provides the use of the skin care composition of the first aspect in the preparation of a cosmetic product with blue light protection efficacy.

[0022] Preferably, the cosmetic product with blue light protection efficacy is any one of a cream, a spray, a serum, and a mask.

[0023] In a third aspect, the present application provides a serum with blue light protection efficacy, which contains 1-10 wt% of the skin care composition with blue light protection efficacy of the first aspect.

[0024] Preferably, the essence with blue light protection efficacy further comprises a humectant, a preservative, a thickening agent, deionized water.

[0025] More preferably, the humectant comprises at least one of sodium hyaluronate, glycerin, butylene glycol, panthenol, allantoin.

[0026] More preferably, the preservative comprises at least one of phenoxyethanol, sorbic acid, potassium sorbate, p-hydroxyacetophenone.

[0027] More preferably, the thickening agent comprises at least one of carrageenan, xanthan gum, carrageenan, carbomer.

[0028] Compared with the prior art, the present application has the following beneficial effects:

[0029] The core pathway of blue light damage is "ROS burst→lipid peroxidation→protein / DNA damage", and the four components provided by the present application can cut off the chain of blue light damage through hierarchical interception:

[0030] Tetrahydro methyl pyrimidine carboxylic acid stabilizes protein structure and reduces ROS generation triggered by light damage; cocoa seed extract and red ginger extract can promote the secretion of antioxidant enzymes through the active substances contained therein to clear the generated ROS; troxerutin and cocoa seed extract can protect cell membrane lipids, down-regulate matrix metalloproteinase (MMP) activity, and promote fibroblast proliferation to avoid further expansion of the chain damage triggered by ROS. The above four substances synergistically enhance from "prevent production→quickly clear→repair damage", and weaken the blue light damage in the whole link. DETAILED DESCRIPTION

[0031] In order to better understand the present application, the present application will be further described below in conjunction with specific examples, wherein the terms "composition" and "essence" used are for describing specific embodiments and do not constitute a limitation on the scope of protection of the present application.

[0032] The experimental methods in the following examples not specified in the specific conditions are usually carried out according to the conventional conditions, or according to the conditions recommended by the manufacturer. Unless otherwise specified, the percentages and mass parts are calculated.

[0033] Some raw materials and sources are as follows:

[0034] Tetrahydro methyl pyrimidine carboxylic acid: purchased from Guangzhou Jinmaier Biological Technology Co., Ltd.; trade name: Ectoine.

[0035] Troxein: Guangzhou Hui Lang Biological Technology Co., Ltd.

[0036] Red ginger extract: Guangzhou Runpei Chemical Co., Ltd.

[0037] Cocoa seed extract: purchased from Ashland LLC; trade name: blumilightTM biofunctional.

[0038] The remaining raw materials and reagents are commercially available.

[0039] The raw materials of the skin care composition with blue light protection efficacy and their mass fractions, and the preparation method are as follows:

[0040] Composition 1

[0041] consisting of the following mass fractions of raw materials:

[0042] Tetrahydro methyl pyrimidine carboxylic acid: 2 parts;

[0043] Troxerutin: 3 parts;

[0044] Red ginger extract: 0.4 parts;

[0045] Cocoa seed extract: 0.3 parts;

[0046] Preparation method:

[0047] Mix tetrahydro methyl pyrimidine carboxylic acid, troxerutin, red ginger extract, cocoa seed extract evenly, seal, and store in dark.

[0048] Composition 2

[0049] consisting of the following mass fractions of raw materials:

[0050] Tetrahydro methyl pyrimidine carboxylic acid: 0.5 parts;

[0051] Tro xerutin: 0.5 parts;

[0052] Red ginger extract: 0.1 parts;

[0053] Cocoa seed extract: 0.1 parts;

[0054] The preparation method is the same as that of composition 1.

[0055] Composition 3

[0056] consisting of the following mass fractions of raw materials:

[0057] Tetrahydro methyl pyrimidine carboxylic acid: 4 parts;

[0058] Tro xerutin: 4 parts;

[0059] Red ginger extract: 0.5 parts;

[0060] Cocoa seed extract: 0.5 parts;

[0061] The preparation method is the same as that of composition 1.

[0062] Composition ①

[0063] Different from composition 1, the tetrahydro methylimidazole carboxylic acid is absent, and the missing mass is made up of troxerutin, red ginger extract, and cocoa seed extract in a mass ratio of 3:0.4:0.3, and the rest of the raw materials and mass parts are the same as composition 1.

[0064] Preparation method: mix troxerutin, red ginger extract, and cocoa seed extract uniformly, seal, and store in the dark.

[0065] Composition 2

[0066] Different from composition 1, the troxerutin is absent, and the missing mass is made up of tetrahydro methylimidazole carboxylic acid, red ginger extract, and cocoa seed extract in a mass ratio of 2:0.4:0.3, and the rest of the raw materials and mass parts are the same as composition 1.

[0067] Preparation method: mix tetrahydro methylimidazole carboxylic acid, red ginger extract, and cocoa seed extract uniformly, seal, and store in the dark.

[0068] Composition 3

[0069] Different from composition 1, the red ginger extract is absent, and the missing mass is made up of tetrahydro methylimidazole carboxylic acid, troxerutin, and cocoa seed extract in a mass ratio of 2:3:0.3, and the rest of the raw materials and mass parts are the same as composition 1.

[0070] Preparation method: mix tetrahydro methylimidazole carboxylic acid, troxerutin, and cocoa seed extract uniformly, seal, and store in the dark.

[0071] Composition 4

[0072] Different from composition 1, the cocoa seed extract is absent, and the missing mass is made up of tetrahydro methylimidazole carboxylic acid, troxerutin, and red ginger extract in a mass ratio of 2:3:0.4, and the rest of the raw materials and mass parts are the same as composition 1.

[0073] Preparation method: mix tetrahydro methylimidazole carboxylic acid, troxerutin, and red ginger extract uniformly, seal, and store in the dark.

[0074] Composition 5

[0075] Composed of the following mass parts of raw materials:

[0076] Tetrahydro methylimidazole carboxylic acid: 0.4 parts;

[0077] Tro xerutin: 0.3 parts;

[0078] Red ginger extract: 2 parts;

[0079] Cocoa seed extract: 3 parts;

[0080] The preparation method is the same as composition 1.

[0081] The components and mass percentages of the essence with the blue light protection efficacy are as follows:

[0082] Essence 1

[0083] consist of the following mass percentage components:

[0084] Composition 1: 5wt%;

[0085] Moisturizer: 3wt%;

[0086] Preservative: 0.1wt%;

[0087] Thickening agent: 0.2wt%;

[0088] Deionized water is supplemented to 100wt%;

[0089] Among them, the moisturizer is glycerol; the preservative is phenoxyethanol; and the thickening agent is carrageenan;

[0090] The preparation method of the essence 1 includes the following steps:

[0091] A1: uniformly mix the moisturizer, the composition, and 1 / 2 amount of deionized water to obtain a mixed liquid A;

[0092] A2: uniformly mix the thickening agent and 1 / 4 amount of deionized water to obtain a mixed liquid B;

[0093] A3: uniformly mix the mixed liquid A, the mixed liquid B, the preservative, and the remaining deionized water to obtain the essence.

[0094] Essence 2

[0095] consist of the following mass percentage components:

[0096] Composition 1: 1wt%;

[0097] Moisturizer: 3wt%;

[0098] Preservative: 0.1wt%;

[0099] Thickening agent: 0.2wt%;

[0100] Deionized water is supplemented to 100wt%;

[0101] Among them, the moisturizer is glycerol; the preservative is phenoxyethanol; and the thickening agent is carrageenan;

[0102] The preparation method is the same as that of the essence 1.

[0103] Essence 3

[0104] consist of the following mass percentage components:

[0105] Composition 1: 10wt%;

[0106] Moisturizer: 3wt%;

[0107] Preservative: 0.1wt%;

[0108] Thickening agent: 0.2wt%;

[0109] Deionized water to 100wt%;

[0110] The moisturizer is glycerin; the preservative is phenoxyethanol; and the thickening agent is carrageenan.

[0111] The preparation method is the same as that of the serum 1.

[0112] Serum 4

[0113] Composed of the following mass percentage components:

[0114] Composition 2: 5wt%;

[0115] Moisturizer: 3wt%;

[0116] Preservative: 0.1wt%;

[0117] Thickening agent: 0.2wt%;

[0118] Deionized water to 100wt%;

[0119] The moisturizer is glycerin; the preservative is phenoxyethanol; and the thickening agent is carrageenan.

[0120] The preparation method is the same as that of the serum 1.

[0121] Serum 5

[0122] Composed of the following mass percentage components:

[0123] Composition 3: 5wt%;

[0124] Moisturizer: 3wt%;

[0125] Preservative: 0.1wt%;

[0126] Thickening agent: 0.2wt%;

[0127] Deionized water to 100wt%;

[0128] The moisturizer is glycerin; the preservative is phenoxyethanol; and the thickening agent is carrageenan.

[0129] The preparation method is the same as that of the serum 1.

[0130] Serum ①

[0131] The composition 1 is replaced by the composition 1 in equal mass, and the other components and their mass percentages, the preparation method of the serum, and the process parameters are the same as those of the serum 1.

[0132] Serum 2

[0133] The composition 1 is replaced by the composition 2 in equal mass, and the other components and their mass percentages, the preparation method of the serum, and the process parameters are the same as those of the serum 1.

[0134] Serum 3

[0135] The composition 1 is replaced by the composition 3 in equal mass, and the other components and their mass percentages, the preparation method of the serum, and the process parameters are the same as those of the serum 1.

[0136] Serum 4

[0137] The composition 1 is replaced by the composition 4 in equal mass, and the other components and their mass percentages, the preparation method of the serum, and the process parameters are the same as those of the serum 1.

[0138] Serum 5

[0139] The composition 1 is replaced by the composition 5 in equal mass, and the other components and their mass percentages, the preparation method of the serum, and the process parameters are the same as those of the serum 1.

[0140] Blank serum

[0141] Composed of the following mass percentage components:

[0142] Humectant: 3wt%;

[0143] Preservative: 0.1wt%;

[0144] Thickening agent: 0.2wt%;

[0145] Deionized water is added to 100wt%;

[0146] Among them, the humectant is glycerol; the preservative is phenoxyethanol; the thickening agent is carrageenan;

[0147] The preparation method of the blank serum includes the following steps:

[0148] A1: Mix the humectant with 1 / 2 of the amount of deionized water uniformly to obtain a mixed liquid A;

[0149] A2: Mix the thickening agent with 1 / 4 of the amount of deionized water uniformly to obtain a mixed liquid B;

[0150] A3: Mix the mixed solution A, the mixed solution B, the preservative, and the remaining deionized water uniformly to obtain the serum.

[0151] Blue light protection performance detection:

[0152] Test samples: compositions 1-3, compositions ①-⑤.

[0153] Test principle: After the skin is irradiated by blue light, active oxygen (ROS) is generated in the skin. When the generated ROS exceeds the self-clearing capacity, oxidative stress damage is induced, which further activates inflammatory response, releases a variety of inflammatory-related factors such as PGE2, and thus induces the occurrence of clinical phenomena such as skin redness.

[0154] Main cells and reagents:

[0155] Cells: normal human epidermal keratinocytes (NHEK, BeNa Biotech, No. BNCC340593); reagents: EMEM complete medium (BeNa Biotech, No. BNCC338137), phosphate buffer solution (PBS) (BeNa Biotech, No. BNCC341451), MTT (Bi Yun Tian, No. C00095), DMSO (Solei Bo, No. D8371), ROS kit (Bi Yun Tian, No. S0034S), human prostaglandin E2 (PGE2) kit (Shanghai Enzyme-Linked, No. ml024761), and the rest of the reagents are commercially available.

[0156] Test method:

[0157] 1) Cell inoculation: inoculate cells into a 6-well plate at a density of 1.8 x 10 5 cells / well, and incubate in an incubator (37°C, 5% CO2) overnight.

[0158] 2) Test grouping: set up a blank control group (BC), a negative control group (NC), and a sample group, and set up 3 repeated wells for each group.

[0159] 3) Liquid preparation: prepare the test sample into a 1wt% sample group working solution using EMEM complete medium.

[0160] 4) Drug administration: when the plating rate of cells in the 6-well plate reaches 40%-60%, administer the drug. The blank control group and the negative control group each add 2mL of EMEM complete medium per well; the sample group each add 2mL of sample group working solution per well; after the drug administration is completed, place the 6-well plate in an incubator (37°C, 5% CO2) for culture.

[0161] Active oxygen (ROS) detection

[0162] 1) Loading active oxygen detection probe: after 24h of cell administration culture, the cells were washed with PBS, and the active oxygen detection probe loading method was operated according to the kit instructions.

[0163] 2) Blue light irradiation: the negative control group and sample group after loading the active oxygen detection probe were irradiated with 440nm wavelength blue light for 10min, at the same time, the blank control group was placed in the same environment, but not irradiated with blue light. After the irradiation was completed, the fresh EMEM complete medium was replaced, and the 6-well plate was placed in the incubator (37℃, 5% CO2) for culture incubation for 30min.

[0164] 3) Detection: after the cell incubation culture for 30min, the supernatant was discarded, the cells were trypsinized and collected, the cells were washed once with PBS, 500μL PBS was added to resuspend the cells, and the cells were detected. The resuspended cells of the sample group were detected on the flow cytometer, and the FITC channel fluorescence signal intensity (MFI) of each sample group was recorded.

[0165] ROS inhibition rate of each sample group = (MFI value of negative control group - MFI value of sample group) / MFI value of negative control group x 100%

[0166] PGE2 detection

[0167] The cell culture supernatant was collected, and the detection operation was carried out according to the PGE2 kit instructions, and the PGE2 content of the sample group was calculated.

[0168] PGE2 inhibition rate of each sample group = (PGE2 content of negative control group - PGE2 content of sample group) / PGE2 content of negative control group x 100%

[0169] The test results are shown in Table 1 below.

[0170] Table 1 Blue light protection efficacy test results of the composition

[0171] Group ROS inhibition rate / % PEG2 inhibition rate / % Composition 1 60.7 52.4 Composition 2 58.1 50.1 Composition 3 58.6 51.3 Composition ① 25.3 27.6 Composition ② 39.6 34.5 Composition ③ 35.2 30.7 Composition ④ 34.3 32.4 Composition ⑤ 40.2 43.2

[0172] According to the data in Table 1, compositions 1-3 and compositions ①-⑤ can effectively inhibit the release of ROS and PEG2 from NHEK cells, indicating that the composition provided by the present application has significant blue light protection efficacy; comparing the results of composition 1 and compositions ①-④, it can be seen that there is a certain synergistic effect between tetrahydro methyl pyrimidine carboxylic acid, troxerutin, red ginger extract and cocoa seed extract in the composition, and the combined use can significantly improve the blue light protection efficacy of the composition; comparing the results of compositions 1-3 and composition ⑤, it can be seen that the amount of the raw materials in the composition will affect the blue light protection efficacy of the composition, and when the amount of each raw material falls within the range defined by the present application, the obtained composition has better blue light protection efficacy.

[0173] Safety test

[0174] The biological safety of the essences 1-5, essences ①-⑤ and the blank essence is verified by experiments.

[0175] The irritation of the cosmetic is evaluated by taking the Cosmetics Safety Technical Specification in 2015 as a reference standard, the test method is a skin patch test, and the test is performed on the subjects randomly distributed in the age of 16-65 years old. The subjects are randomly grouped, each group corresponds to one essence, and each group has 30 subjects.

[0176] Test method: the test object is placed in a patch tester, the amount is 0.020-0.025 g, the patch tester with the test object is covered on the back or the curved side of the forearm of the subject with a non-irritating cloth-based adhesive tape, and the skin surface is uniformly attached by pressing with the palm for 24 hours. After 30 minutes of removing the test patch tester, the skin reaction is observed after the indentation disappears. If the result is negative, the observation is performed again at 24 hours and 48 hours after the patch test.

[0177] Evaluation criteria:

[0178] 0 level: negative reaction;

[0179] 1 level: suspicious reaction, only weak erythema;

[0180] 2 level: weak positive reaction, erythema, infiltration, edema, and can have papules;

[0181] 3 level: strong positive reaction, erythema, infiltration, edema, and can have papules, and the reaction can exceed the test area;

[0182] 4 level: very strong positive reaction, obvious erythema, severe infiltration, edema, and fusion of herpes, and the reaction exceeds the test area.

[0183] Test result: the skin reaction of all subjects is negative, indicating that the essence provided by the application is safe and non-irritating.

[0184] Human efficacy test

[0185] Test purpose and principle: Blue light can penetrate to the dermis layer of the skin. Under blue light irradiation, active oxygen free radicals are produced in the mitochondria of cells, and oxidative reactions occur with mitochondria, DNA, and cell structures containing lipids such as cell membranes, mitochondrial membranes, and lysosomes, damaging mitochondria and DNA, affecting cell growth and development, destroying cell structure, causing cell damage leading to apoptosis. From the appearance, blue light induces the production of free radicals in cells, causing damage to dermal fibroblasts and reducing the extracellular matrix, thereby leading to premature aging and darkening of the skin. In addition, blue light irradiation generates a large amount of heat, causing the arm to turn red and black in a short period of time, and the skin epidermis to become dry and produce a local irritation reaction in a short period of time. The blue light protection efficacy of the test sample can be evaluated by detecting the change rate of skin melanin, red pigment, and skin brightness.

[0186] Test instruments: A multifunctional skin detector and the 7th generation VISIA were used to detect and photograph the changes in the red area after blue light irradiation, and the changes in ITA, melanin, and red pigment were analyzed to evaluate the blue light protection efficacy of the test sample.

[0187] Test samples: Serum 1-5, serum 1-5, and blank serum.

[0188] Subject selection: Healthy subjects aged 20-60 years old, male and female, each corresponding to 11 test samples, a total of 30 people.

[0189] Test method: The back of the subject was washed, the water was absorbed with a paper towel, and the back was dried and equilibrated in a constant temperature and humidity chamber (temperature 20±2℃, relative humidity 50±5%) for 25±5min. Twelve test areas were marked on the back, and the twelve test areas were divided into 11 irradiation test areas and 1 non-irradiation test area. The 11 irradiation test areas were applied with 20μL of the designated test sample, and the non-irradiation test area was applied with an equal amount of blank serum, and was left to stand at room temperature for 10min. The irradiation test areas were irradiated with a red and blue light treatment instrument at the same distance, same method, and same blue light irradiation dose (blue light irradiation dose 7min, 30J / cm 2 After irradiation of the test areas, the ITA value, melanin content, and hemoglobin content of the skin were detected using CL400 and MX18 probes. During the irradiation of the irradiation test areas, the non-irradiation test areas were covered with an opaque cloth to prevent them from being irradiated by blue light.

[0190] Experimental instruments: Multifunctional skin detector (purchased from CK, model MPA6); VISIA (purchased from the United States Canfield, model seventh generation); red and blue light treatment instrument (purchased from Sigma, model SP-3BR).

[0191] The test period is 30 days, and the test sample is applied and irradiated once a day.

[0192] Data analysis: taking the detection data of the blank serum group (not irradiated) as 100%, calculate the influence of the sample on each parameter of the skin. The calculation formula is as follows:

[0193] Wherein, the larger the ITA value, the whiter the skin; the lower the melanin value, the smaller the melanin content in the skin; the lower the red pigment content, the less the red pigment content in the skin.

[0194] Calculation formula: change rate = detection value A / detection value 未照射 × 100%

[0195] Wherein, the detection value A is the detection value of the irradiation group, and the detection value 未照射 is the detection value of the non-irradiation group.

[0196] Table 2: Blue light protection efficacy test results of serum

[0197]

[0198] According to the results in Table 2, compared with the results of the blank serum of the non-irradiation group and the irradiation group, it can be seen that the blue light irradiation can significantly increase the melanin and red pigment content in the skin of the test area, and significantly reduce the ITA value; the serum 1-5 in the present application all have a certain blue light protection efficacy, compared with the results of serum 1-5, serum ①-⑤ and blank serum in the irradiation group, it can be seen that the addition and amount of the composition have a significant influence on the blue light protection efficacy of the serum; compared with the results of serum 1-3 and the blank serum of the irradiation group, it can be seen that the amount of the composition has a significant influence on the blue light protection efficacy of the serum, compared with the results of serum 1-3, it can be seen that serum 1 has the best cost performance; compared with the results of serum 1 and serum 4, 5 and serum ⑤, it can be seen that the amount of each raw material in the composition has a significant influence on the blue light protection efficacy of the serum, when the amount of the raw material used in the composition is not within the range defined in the present application, the efficacy is poor; compared with the results of serum 1 and serum ①-④, it can be seen that there is a significant synergistic effect between each raw material in the composition, and when used together, it has a significant blue light protection efficacy.

[0199] The above examples are the preferred embodiments of the present application, but the embodiments of the present application are not limited by the above examples, any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present application should be equivalent replacement methods, and are all included in the protection scope of the present application.

Claims

1. A skincare composition with blue light protection function, characterized in that, The skincare composition comprises the following ingredients in parts by weight: Tetrahydromethylpyrimidine carboxylic acid: 0.5-4 parts; Troxerutin: 0.5-4 parts; Red ginger extract: 0.1-0.5 parts; Cocoa seed extract: 0.1-0.5 parts.

2. The skincare composition according to claim 1, characterized in that, The skincare composition comprises the following ingredients in parts by weight: Tetrahydromethylpyrimidine carboxylic acid: 2 parts; Troxerutin: 3 parts; Red ginger extract: 0.4 parts; Cocoa seed extract: 0.3 parts.

3. The use of the skin care composition with blue light protection as described in claim 1 or 2 in the preparation of cosmetics with blue light protection.

4. The application as described in claim 3, characterized in that, The cosmetic product with blue light protection function is any one of face cream, spray, serum, or mask.

5. A serum with blue light protection function, characterized in that, The serum contains 1-10 wt% of the skincare composition as described in claim 1 or 2.

6. The essence as described in claim 5, characterized in that, The serum also includes moisturizers, preservatives, thickeners, and deionized water.

7. The essence as described in claim 6, characterized in that, The moisturizer includes at least one of sodium hyaluronate, glycerin, butylene glycol, panthenol, and allantoin.

8. The essence as described in claim 6, characterized in that, The preservative includes at least one of phenoxyethanol, sorbic acid, potassium sorbate, and p-hydroxyacetophenone.

9. The essence as described in claim 6, characterized in that, The thickener includes at least one of carrageenan, xanthan gum, carrageenan, and carbomer.

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