Production process of florfenicol premix with content of 2%

Abstract

The invention discloses a production process of a florfenicol premix with the content of 2%, and belongs to the field of preparation of florfenicol with the content of 2%. Comprising the following steps: mixing florfenicol, maltodextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran, and granulating by using a granulator; drying and finishing the granules prepared by the granulator to obtain 2% florfenicol mixed granules with uniform diameter; totally mixing the 2% florfenicol mixed particles to obtain 2% florfenicol premix mixed particles; and packaging the 2% florfenicol premix mixed particles. The florfenicol premix has the beneficial effects that the core problems of poor uniformity, low stability, poor flowability and the like existing in a low-concentration florfenicol premix for a long time are successfully solved through a specific auxiliary material formula and key process combination of granulation, drying and finishing and total mixing; the invention provides an ideal preparation method which is stable in quality, safe and convenient to use and high in production efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of 2% florfenicol preparation, in particular, to a production process of 2% florfenicol premix. BACKGROUND

[0002] Florfenicol is a broad-spectrum and high-efficiency animal-specific amphenicol antibiotic, which is widely used in livestock and poultry and aquaculture for treating diseases such as respiratory and digestive tract infections caused by sensitive bacteria. In order to facilitate uniform feeding in feed, it is often prepared into a low-concentration premix form (such as 2%).

[0003] The preparation of traditional florfenicol premix mostly adopts a simple physical mixing method (such as equal incremental mixing). However, for low-concentration (such as 2%) premix, due to the low content of the main drug, the large difference in density and particle size from the carrier, it is easy to cause uneven mixing. Uneven mixing will directly cause fluctuations in the drug concentration in the feed, affecting the treatment effect, and even may cause local drug overdose to induce poisoning or drug deficiency to induce drug resistance. At the same time, florfenicol itself has certain hygroscopicity and electrostatic adsorption, and during storage and transportation, the simple physical mixture is easy to cause problems such as delamination, segregation and caking, resulting in a decrease in content uniformity and stability.

[0004] Some existing granulation processes may not be optimized for the characteristics of florfenicol and the requirements of low-concentration premix. For example, improper selection of excipients may cause difficulty in granulation, poor particle hardness or friability, and poor flowability; improper control of drying conditions may affect the stability of the drug or the quality of the granules; lack of effective granulation and final total mixing steps makes it difficult to ensure the high uniformity of large batches of products within and between batches. These problems limit the quality, safety and market application of low-concentration florfenicol premix. SUMMARY

[0005] The summary portion of the present application is used to introduce the concepts in a brief form, which will be described in detail in the specific embodiments section. The summary portion of the present application is not intended to identify key or essential features of the claimed technical solutions, nor is it intended to limit the scope of the claimed technical solutions.

[0006] In order to solve the technical problems mentioned in the background section, some embodiments of the present application provide a production process of 2% florfenicol premix, comprising: mixing florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran and using a granulator to granulate; drying and granulating the granules prepared by the granulator to obtain 2% florfenicol mixed granules with uniform particle size; total mixing the 2% florfenicol mixed granules to obtain 2% florfenicol premix mixed granules; and packaging the 2% florfenicol premix mixed granules.

[0007] Further, the production process of the Florfenicol premix with 2% content further comprises weighing Florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran in an environment with temperature of 18-26℃, relative humidity of 45-65% and relative negative pressure ≥5Pa.

[0008] Further, the drying temperature is 85-95℃; and the drying is stopped after the material temperature reaches 47-51℃.

[0009] Further, the rotating speed of the total mixing process is 8r / min; and the mixing time is 20min.

[0010] Further, the granulating method using the granulator comprises: dry mixing and cutting in a granulating pot, the dry mixing and cutting time is 150s; adding purified water into the granulating pot, and after stirring for 120s, adding into a swing granulator with rotating speed of 55r / min.

[0011] Further, the granulating method comprises: slowly adding the dried granules into the vibrating screen.

[0012] Further, the vibrating screen comprises: a screen, a connecting piece, a transmission piece and a driving piece; the connecting piece is connected with the screen, and the connecting piece is arranged in the middle part of the screen; the transmission piece is used for tightening and relaxing the screen; the driving piece is used for driving the connecting piece to move upwards and downwards; when the connecting piece moves upwards, the middle part of the screen protrudes upwards, so that the other part of the screen forms a downward inclined discharge slope.

[0013] Further, the connecting piece comprises: a mounting body and a pressing rod; a containing groove is arranged in the mounting body, and the pressing rod is partially located in the containing groove; the screen is partially sunk into the containing groove, the mounting body is located at the lower side of the screen, and the pressing rod is located at the upper side of the mounting body; the transmission piece is used for relatively moving the pressing rod and the mounting body, so as to tighten and relax the screen; and the driving piece is used for driving the mounting body to move upwards and downwards.

[0014] Further, the transmission piece comprises: a push rod; the push rod is arranged in the containing groove, and the push rod is located at the lower side of the screen; an elastic piece is arranged above the pressing rod, and the elastic piece is used for applying downward pressure to the pressing rod; and the driving piece is also used for driving the push rod to move upwards and downwards.

[0015] Further, the driving member comprises at least an air pump and an air injection pipe, the push rod comprises multiple telescopic sections, the air pump injects air into the telescopic sections through the air injection pipe to make the push rod lengthen and shorten; when the push rod lengthens, the push rod drives the screen to move upwards, and when the push rod shortens, the push rod drives the screen to move downwards; multiple pressure relief holes are arranged on the telescopic sections, and an air outlet hole is arranged on the mounting body, the air pump makes the air sequentially pass through the telescopic sections, the pressure relief holes, the accommodating grooves and the air outlet hole and then be discharged; the air outlet hole is inclined upward, and the air outlet hole is located below the screen.

[0016] The application has the following advantages:

[0017] By using specific excipients (malt dextrin, corn starch, hydroxypropyl methyl cellulose, defatted rice bran) and granulation process, the drug and excipients are closely combined in the granules, effectively overcoming the mixing unevenness and delamination caused by density difference and static electricity of low-concentration drugs. The subsequent granulation and final mixing process further ensures the uniformity of granule size and the overall mixing uniformity, thereby significantly improving the content uniformity of the final premix product and ensuring the accurate and reliable dosage of the drug added in the feed.

[0018] The granule structure formed during the granulation process and the coating effect of excipients such as hydroxypropyl methyl cellulose reduce the contact area between florfenicol and air, effectively reducing its hygroscopicity and oxidation degradation risk. The granule form is less likely to delaminate and cake than the powder mixture, greatly improving the physical and chemical stability of the product during storage and transportation, and prolonging the shelf life.

[0019] After granulation, drying and granulation, granules with uniform particle size are obtained, significantly improving the flowability of the material. Excellent flowability allows the premix to be smoothly discharged and accurately metered during subsequent packaging. More importantly, when mixed with a large proportion of feed in the feed mill, it can be dispersed more quickly and uniformly into the feed, avoiding local aggregation.

[0020] The granulation process converts fine powder material into granules, effectively reducing dust flying during production (especially during mixing and packaging), improving the production operating environment, reducing the health risk to operators, and reducing cross-contamination and loss of drugs.

[0021] The process steps are clear (mixing and granulation → drying and granulation → total mixing → packaging), and the parameters of each link (such as granulation conditions, drying temperature and time, and granulation screen mesh size) are easy to control. Combined with the selection of specific excipients, this process has good reproducibility and scalability, and can stably produce 2% florfenicol premix with consistent quality and in accordance with standards.

[0022] Reasonable granulation process and excipient selection (such as hydrophilic excipients) help the wetting and dispersion of drug particles in water or animal digestive tract environment, which may be beneficial to the dissolution of the drug, and thus potentially improve its bioavailability.

[0023] By specific excipient formula and the combination of the key processes of "granulation + drying and whole granulation + total mixing", the core problems of poor uniformity, low stability and poor flowability of the long-existing low-concentration florfenicol premix are successfully solved, and an ideal preparation method with stable quality, safe and convenient use and high production efficiency is provided. BRIEF DESCRIPTION OF DRAWINGS

[0024] The accompanying drawings, which form a part of this application, are intended to provide further understanding of the application and are incorporated herein for a purpose of explanations and are in no way limiting to the present application.

[0025] In addition, throughout the drawings, the same or similar reference numerals designate the same or similar elements. It should be understood that the drawings are schematic, and the elements and elements are not necessarily drawn according to the scale.

[0026] In the drawings:

[0027] Figure 1 is a whole schematic diagram according to the embodiment of the present application;

[0028] Figure 2 is a structural schematic diagram of a part of the embodiment, mainly showing the sectional structure of Figure 1

[0029] Figure 3 is a structural schematic diagram of a part of the embodiment, mainly showing the local structure of Figure 2

[0030] Reference numerals:

[0031] 1, screen;

[0032] 2, driving member;

[0033] 3, fixed frame; 31, main body; 32, first ring wall; 33, second ring wall; 34, third ring wall; 35, first annular receiving hopper; 36, second annular receiving hopper;

[0034] 4, first transmission member; 41, first mounting body; 42, first pressing rod;

[0035] 5, first connecting member; 51, first push rod;

[0036] 6, first elastic member;

[0037] ​​7. Second transmission member; 71. Second mounting body; 72. Second pressing rod;

[0038] 8. Second connecting member; 81. Second pushing rod;

[0039] 9. Second elastic member. DETAILED DESCRIPTION

[0040] Embodiments of the present disclosure will be described in more detail with reference to the drawings. Although certain embodiments of the present disclosure are shown in the drawings, it is understood that the present disclosure can be embodied in various forms and should not be interpreted as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that the present disclosure can be more thoroughly and completely understood. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0041] In addition, it should be further noted that only the parts related to the present application are shown in the drawings for ease of description. The embodiments in the present disclosure and the features in the embodiments can be combined with each other without conflict.

[0042] It should be noted that the concepts of "first", "second", etc. mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not used to limit the order or interdependence of the functions performed by these devices, modules or units.

[0043] It should be noted that the modification of "one" or "multiple" in the present disclosure is illustrative and not restrictive, and those skilled in the art should understand that unless otherwise explicitly indicated in the context, it should be understood as "one or more".

[0044] The present disclosure will be described in detail below with reference to the drawings and in conjunction with embodiments.

[0045] Reference Figures 1-3 ,

[0046] A production process of a 2% florfenicol premix agent includes: mixing florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran and granulating using a granulator; drying and granulating the granules prepared by the granulator to obtain 2% florfenicol mixed granules with uniform particle size; total mixing the 2% florfenicol mixed granules to obtain 2% florfenicol premix agent mixed granules; and packaging the 2% florfenicol premix agent mixed granules.

[0047] Further, the production process of the 2% florfenicol premix agent further includes weighing the florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran in an environment with a temperature of 18-26°C, a relative humidity of 45-65% and a relative negative pressure ≥ 5 Pa.

[0048] Further, the drying temperature is 85-95℃; and the drying is stopped after the material temperature reaches 47-51℃.

[0049] Further, the rotating speed of the total mixing process is 8r / min; and the mixing time is 20min.

[0050] Further, the granulating method using the granulator includes: dry mixing and cutting in a granulating pot, the dry mixing and cutting time is 150s; and purified water is added into the granulating pot, and after stirring for 120s, it is added into a swing granulator with a rotating speed of 55r / min.

[0051] Further, the granulating method includes: slowly adding the dried granules into the vibrating screen.

[0052] In some other embodiments, the vibrating screen includes: a screen 1, a connecting piece, a transmission piece and a driving piece 2. The connecting piece is connected with the screen 1, and the connecting piece is arranged at the middle part of the screen 1. The transmission piece is used to tighten and relax the screen 1. The driving piece 2 is used to drive the connecting piece to move upwards and downwards. When the connecting piece moves upwards, the middle part of the screen 1 protrudes upwards, so that the other parts of the screen 1 form a downward inclined discharge slope.

[0053] By adopting the above technical scheme, the tightness of the screen 1 can be adjusted to better adapt to different vibration requirements, and the screen 1 can be tightened when it is deformed to improve the service life. Since the large-particle materials cannot be filtered out downwards on the screen 1 when the materials on the screen 1 are screened by vibration, the materials are prone to accumulate on the screen 1, which is troublesome to collect later. The driving piece 2 is used to move the connecting piece upwards in the present application, so that the middle part of the screen 1 protrudes upwards, and the other parts of the screen 1 form a downward inclined discharge slope. The large-particle materials on the screen 1 can be better collected on the discharge slope to the edge of the screen 1, so that the collection of the large-particle materials is facilitated.

[0054] Specifically, the connecting piece includes: a mounting body and a pressing rod. The mounting body is provided with a receiving groove, and the pressing rod is partially located in the receiving groove. The screen 1 is partially sunk into the receiving groove, the mounting body is located at the lower side of the screen 1, and the pressing rod is located at the upper side of the mounting body. The transmission piece is used to move the pressing rod and the mounting body relative to each other to tighten and relax the screen 1; and the driving piece 2 is used to drive the mounting body to move upwards and downwards. The 2% content florfenicol premix production process also includes a fixing frame 3, the driving piece 2 is arranged on the fixing frame 3, the driving piece 2 can adopt a pneumatic cylinder or a hydraulic cylinder, and the driving piece 2 directly drives the mounting body to move upwards and downwards.

[0055] Specifically, the transmission member comprises a push rod. The push rod is arranged in the accommodating groove, and the push rod is located at the lower side of the screen 1. An elastic member is arranged above the push rod, and the elastic member is used to apply downward pressure to the push rod. The driving member 2 is also used to drive the push rod to move upward and downward. The driving member 2 is composed of at least two cylinders or hydraulic cylinders, one of which drives the mounting body to move, and the other of which drives the push rod to move. By arranging the screen 1 into the accommodating groove and adjusting the degree of arrangement of the screen 1, the tightness of the screen 1 is changed, and the screen 1 can be lifted in the middle part to make the large-particle material fall into the edge position of the screen 1. In addition, the elastic member is a spring, and the push rod is in sliding connection with the fixed frame 3.

[0056] In some other embodiments, two screens 1 are arranged. The two screens 1 are arranged in an up-down position, and the screen 1 arranged at the upper position is used to screen out the material smaller than the required particle size and leave the material larger than the required particle size. The screen 1 arranged at the lower position is used to screen out the broken material smaller than the required particle size and leave the material equal to the required particle size, and then the material meeting the required particle size is discharged outward and collected.

[0057] In this embodiment, two sets of driving members 2, transmission members and connecting members are arranged, and are arranged in one-to-one correspondence with the screen 1 arranged at the upper position and the screen 1 arranged at the lower position. Therefore, it is convenient to quickly collect the large-particle waste and quickly collect the material meeting the composite requirements. The collection speed is greatly improved, thereby avoiding the situation that the screening speed is affected due to long-time shutdown.

[0058] In some other embodiments, one set of driving members 2 is arranged, and two sets of transmission members and connecting members are arranged, and are arranged in one-to-one correspondence with the screen 1 arranged at the upper position and the screen 1 arranged at the lower position. In order to facilitate description, the transmission member corresponding to the screen 1 arranged at the upper position is described as a first transmission member 4, the connecting member is described as a first connecting member 5, and the elastic member is described as a first elastic member 6. The transmission member corresponding to the screen 1 arranged at the lower position is described as a second transmission member 7, the connecting member is described as a second connecting member 8, and the elastic member is described as a second elastic member 9.

[0059] The first connecting member 5 comprises a first mounting body 41 and a first push rod 42. The first transmission member 4 comprises a first push rod 51.

[0060] The second connecting member 8 comprises a second mounting body 71 and a second push rod 72. The second transmission member 7 comprises a second push rod 81.

[0061] The accommodating groove of the first mounting body 41 is a first accommodating groove, and the accommodating groove of the second mounting body 71 is a second accommodating groove.

[0062] The first pressing rod 42 is in sliding connection with the fixing frame 3, and the first elastic member 6 is connected with the first pressing rod 42. The first accommodating groove and the second accommodating groove are through grooves, the second pressing rod 72 is in abutment with the inner wall of the first accommodating groove, that is, the second pressing rod 72 is in sliding connection with the first mounting body 41. The second pressing rod 72 has an abutment portion on the outer wall, and the second elastic member 9 is arranged between the abutment portion and the first mounting body 41, so that a downward force is applied to the second pressing rod 72. The first pushing rod 51 is fixed with the second pressing rod 72. The driving member 2 is used to drive the second pushing rod 81 to move upward and downward, so that the first pushing rod 51 moves upward and then moves downward under the action of the first elastic member 6 or the first pushing rod 51 when the second pushing rod 81 moves upward or downward. Two screen meshes 1 can be simultaneously tensioned or relaxed, or the middle portions of the two screen meshes 1 can be protruded upward to unload.

[0063] In some other embodiments, the production process of the florfenicol premix with a content of 2% also includes a main body 31. The main body 31 is provided with a first discharge groove and a second discharge groove. The first discharge groove is used to discharge the material on the upper screen mesh 1 outward. The second discharge groove is used to discharge the material on the lower screen mesh 1 outward. The main body 31 includes a first ring wall 32, a second ring wall 33, a third ring wall 34, and a connecting rod connecting the first ring wall 32, the second ring wall 33, and the third ring wall 34. The first discharge groove is arranged between the first ring wall 32 and the second ring wall 33, and the second discharge groove is arranged between the second ring wall 33 and the third ring wall 34. A first annular receiving hopper 35 is arranged outside the first discharge groove, and a second annular receiving hopper 36 is arranged outside the second discharge groove. The bottom surfaces of the first annular receiving hopper 35 and the second annular receiving hopper 36 are both outwardly inclined, which facilitates the rapid receiving of the materials discharged outward by the first discharge groove and the second discharge groove. The first annular receiving hopper 35 is fixed with the second ring wall 33, and the second annular receiving hopper 36 is fixed with the third ring wall 34.

[0064] The first annular receiving hopper 35 and the second annular receiving hopper 36 are both provided with discharge ports, and the outer walls of the discharge ports are gradually inclined upward, thereby facilitating the outward discharge of the materials in the first annular receiving hopper 35 and the second annular receiving hopper 36.

[0065] In some other embodiments, the screen mesh 1 is composed of a first mesh body and a second mesh body which are overlapped together. Taking the screen mesh 1 near the first mounting body 41 as an example, the first mesh body and the second mesh body are both directly arranged on the first mounting body 41, and the first mesh body and the second mesh body are pressed into the accommodating groove of the first mounting body 41 by the first pressing rod 42. In actual use, the meshes on the first mesh body and the meshes on the second mesh body are overlapped, and when the first mesh body and the second mesh body move relatively, the aperture of the screen mesh 1 can be made larger or smaller.

[0066] The relative movement of the first mesh body and the second mesh body can be achieved in the following ways:

[0067] The first net body and the second net body are relatively rotated. The first discharging groove is further provided with a rotating ring, the rotating ring is sleeved outside the first ring wall 32, and the rotating ring is rotationally connected with the first ring wall 32. The first net body is fixed with the rotating ring, and the second net body is fixed with the first ring wall 32, so that the first net body and the second net body can be rotated relative to each other. Thus, the size of the mesh holes of the screen 1 can be adjusted.

[0068] In some other embodiments, the driving member 2 further comprises an air pump and an air injection pipe, and the push rod comprises multiple telescopic sections, i.e., telescopic pipes. The air pump injects air into the telescopic sections through the air injection pipe, so as to lengthen and shorten the push rod. When the push rod is lengthened, the push rod drives the screen 1 to move upwards, and when the push rod is shortened, the push rod drives the screen 1 to move downwards. Multiple pressure relief holes are arranged on the telescopic sections, and an exhaust hole is arranged on the mounting body. The air pump makes the air sequentially pass through the telescopic sections, the pressure relief holes, the accommodating groove and the exhaust hole and then be discharged. The exhaust direction of the exhaust hole is inclined upward, and the exhaust hole is located below the screen 1. The exhaust hole discharges air outward, so that the air can be discharged from below to above the screen 1, which has a backflushing effect on the screen 1 and prevents the screen 1 from being blocked to a certain extent.

[0069] The above description is merely some preferred embodiments of the present disclosure and a description of the technical principles used. Those skilled in the art should understand that the inventive scope of the embodiments of the present disclosure is not limited to the technical solutions formed by the specific combinations of the above technical features, and should also cover other technical solutions formed by the combinations of the above technical features or equivalent features without departing from the above inventive concept. For example, the above features and the technical features disclosed in the embodiments of the present disclosure (but not limited to) having similar functions are replaced with each other to form technical solutions.

Claims

1. A process for the production of Florfenicol premix at 2% level characterized by, The application relates to a 2% florfenicol premix production process. Florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran are mixed and granulated by using a granulator; The granules prepared by the granulator are dried and granulated to obtain 2% florfenicol mixed granules with uniform diameters; The 2% florfenicol mixed granules are totally mixed to obtain 2% florfenicol premix mixed granules; The 2% florfenicol premix mixed granules are packaged.

2. The 2% florfenicol premix production process according to claim 1, wherein: The 2% florfenicol premix production process further comprises weighing florfenicol, malt dextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran in an environment with a temperature of 18-26 DEG C, a relative humidity of 45-65% and a relative negative pressure of greater than or equal to 5 Pa.

3. The 2% florfenicol premix production process according to claim 1, wherein: The drying temperature is 85-95 DEG C; and the drying is stopped after the material temperature reaches 47-51 DEG C.

4. The 2% florfenicol premix production process according to claim 1, wherein: The rotating speed of the total mixing process is 8 r / min; and the mixing time is 20 min.

5. The 2% florfenicol premix production process according to claim 1, wherein: The granulation method by using the granulator comprises: Dry mixing and cutting are carried out in a granulation kettle, and the dry mixing and cutting time is 150 s; Purified water is added to the granulation kettle, and after stirring for 120 s, the purified water is added to a swing granulator with a rotating speed of 55 r / min.

6. The 2% florfenicol premix production process according to claim 1, wherein: The granulation method comprises: The dried granules are slowly added to a vibrating screen.

7. The 2% florfenicol premix production process according to claim 1, wherein: The vibrating screen comprises a screen, a connecting piece, a transmission piece and a driving piece; The connecting piece is connected with the screen, and the connecting piece is arranged at the middle part of the screen; The transmission piece is used for tightening and relaxing the screen; and the driving piece is used for driving the connecting piece to move upwards and downwards; When the connecting piece moves upwards, the middle part of the screen protrudes upwards, so that the other part of the screen forms a downwardly-inclined discharging slope.

8. The 2% florfenicol premix production process according to claim 1, wherein: The connecting piece comprises a mounting body and a pressing rod; a containing groove is arranged in the mounting body, and the pressing rod is partially arranged in the containing groove; the screen is partially arranged in the containing groove, the mounting body is arranged at the lower side of the screen, and the pressing rod is arranged at the upper side of the mounting body; The transmission piece is used for relatively moving the pressing rod and the mounting body, so as to tighten and relax the screen; The driving piece is used for driving the mounting body to move upwards and downwards.

9. The 2% florfenicol premix production process according to claim 8, wherein: The transmission piece comprises a push rod; The push rod is arranged in the containing groove, and the push rod is arranged at the lower side of the screen. An elastic member is arranged above the pressing rod, and is used to apply downward pressure to the pressing rod; The driving member is also used to drive the push rod to move upward and downward.

10. The production process of the 2% content of florfenicol premix agent, characterized in that: The driving member at least comprises an air pump and an air injection pipe, the push rod comprises multiple telescopic sections, and the air pump injects air into the telescopic sections through the air injection pipe, so that the push rod is lengthened and shortened; When the push rod is lengthened, the push rod drives the screen mesh to move upward, and when the push rod is shortened, the pressing rod drives the screen mesh to move downward; Multiple pressure relief holes are arranged on the telescopic sections, an exhaust hole is arranged on the mounting body, and the air pump makes the air sequentially pass through the telescopic sections, the pressure relief holes, the containing groove and the exhaust hole and then be discharged; The exhaust direction of the exhaust hole is inclined upward, and the exhaust hole is located below the screen mesh.

Images