Medicinal and edible composition helpful for controlling fat in body and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a medicinal and edible composition helpful for controlling in-vivo fat and a preparation method and application thereof. The medicinal and edible composition is prepared from the following raw materials in parts by weight: 10-50 parts of Chinese yam, 10-50 parts of phaseolus calcaratus, 10-50 parts of black rice, 10-50 parts of buckwheat, 10-30 parts of hawthorn, 20-50 parts of black sesame, 1-20 parts of tangerine pith, 1-20 parts of exocarpium benincasae, 20-50 parts of poria cocos and 10-40 parts of radix fici simplicissimae. The medicinal and edible composition obtained by the invention realizes fat removal and lipid reduction by regulating the functions of viscera, meets the demands of the market on mild fat reduction schemes, and is simple, convenient, low in cost and effective.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a food-medicine homology composition that helps control body fat, its preparation method, and its application. Background Technology

[0002] Against the backdrop of the national strategy of vigorously promoting Healthy China and the three-year action plan specifically for "Weight Management Year," abnormal weight has been clearly defined as a core risk factor for many chronic diseases such as cardiovascular and cerebrovascular diseases and diabetes. Scientific weight management has become a key line of defense for safeguarding the health of the entire population. The "Weight Management Year" campaign, jointly launched by 16 departments including the National Health Commission, particularly emphasizes "giving full play to the technical support role of traditional Chinese medicine in weight management," explicitly proposing the promotion of appropriate TCM technologies related to weight management and the formulation of guidelines for obesity prevention and control interventions for different population groups. This provides clear policy support and development paths for TCM-based weight management products. At the same time, the Healthy China Action has set an overall goal of initially curbing the growth rate of overweight and obesity by 2030. Various regions are actively promoting weight management science popularization in communities, families, and medical institutions, and the public's awareness of weight management is continuously being strengthened.

[0003] From the market demand perspective, the number of obese and overweight people in my country is constantly expanding. However, traditional single-method weight loss often comes with side effects such as rebound weight gain and gastrointestinal irritation. Consumers' demand for products that offer "safe weight loss and gentle conditioning" is becoming increasingly prominent. According to industry forecasts, the market size of Chinese herbal weight loss kits is expected to exceed 26 billion yuan in 2025, with a projected compound annual growth rate of 14.3%. Among them, products formulated to strengthen the spleen and resolve dampness have become the most popular sub-category due to their high alignment with the principles of traditional Chinese medicine conditioning, bringing broad growth potential to related products.

[0004] Based on the etiology and pathogenesis of obesity, medications primarily achieve weight loss by suppressing appetite, reducing food intake, affecting metabolism, increasing energy expenditure, and promoting thermogenesis. According to their pharmacological mechanisms, weight-loss drugs include appetite suppressants, metabolism promoters, digestive and absorption inhibitors, insulin sensitizers, and lipid-lowering drugs.

[0005] Most weight management products on the market today are based on the logic of "burning fat, suppressing appetite, and accelerating metabolism." However, products that address the root cause of obesity, namely the imbalance of digestive and absorptive functions and the accumulation of fat caused by "spleen and kidney qi deficiency" in Traditional Chinese Medicine (TCM), are still relatively scarce. TCM theory holds that the core pathogenesis of obesity lies in spleen and kidney qi deficiency, which leads to impaired digestion and absorption of nutrients, resulting in the inability to separate clear and turbid substances and the accumulation of phlegm and dampness. This is a syndrome of "deficiency in the root and excess in the branch," essentially "spleen and kidney insufficiency and excess of phlegm and dampness."

[0006] Based on this theoretical understanding, we can develop an instant powder product with the core focus of "tonifying the spleen and kidneys and eliminating phlegm and dampness". It has multiple effects such as lightness and hunger resistance, strengthening the spleen and stomach, nourishing yin and kidneys, reducing obesity and lipids, and promoting longevity and health. Made from medicinal and edible raw materials, it can fill a market gap and has great market potential and competitiveness.

[0007] In view of this, the present invention is proposed. Summary of the Invention

[0008] To address the aforementioned technical problems, the present invention aims to provide a medicinal and edible composition that helps control body fat, its preparation method, and its application. The resulting medicinal and edible composition achieves fat reduction and lipid reduction by regulating the functions of internal organs, meeting the market's demand for a gentle fat reduction solution. Moreover, the product is simple, inexpensive, and effective.

[0009] To achieve the above objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides a food-medicine composition that helps control body fat, prepared by weight from the following raw materials: 10-50 parts yam, 10-50 parts red adzuki bean, 10-50 parts black rice, 10-50 parts buckwheat, 10-30 parts hawthorn, 20-50 parts black sesame, 1-20 parts orange peel, 1-20 parts winter melon peel, 20-50 parts Poria cocos, and 10-40 parts five-finger peach.

[0010] In clinical practice, Traditional Chinese Medicine (TCM) believes that the pathogenesis of obesity is due to spleen and kidney qi deficiency, resulting in impaired transportation and distribution of nutrients, mixing of clear and turbid substances, failure to transform essence, blood, and fat, and accumulation of phlegm and dampness, thus leading to obesity. Therefore, this formula uses yam to tonify the spleen and stomach, benefit kidney qi, and resolve phlegm; Poria cocos to invigorate the spleen, drain dampness, calm the mind, and reduce phlegm and turbidity; black rice, sweet and neutral in nature, enters the spleen, stomach, and kidney meridians, and can "nourish blood, nourish yin and kidney, strengthen the body and warm the stomach, clear the liver and moisten the intestines"; red adzuki beans, as recorded in the *Compendium of Materia Medica*, "...cause the leakage of body fluids and blood, thus causing emaciation and heaviness. It promotes urination, reduces edema, strengthens the spleen and stomach, and is suitable for obesity with edema of the hands and feet"; hawthorn strengthens the stomach and aids digestion, clears the bowels and promotes blood circulation; black sesame seeds... This formula nourishes and moisturizes the skin, strengthens the spleen and kidneys, and promotes health and longevity. Buckwheat invigorates the spleen, eliminates stagnation, and removes accumulated waste. Orange peel effectively clears stagnant qi in the meridians and removes phlegm accumulated under the skin and membranes. Winter melon peel promotes urination, aids weight loss, and lowers blood sugar. Five-finger peach (a type of medicinal herb) invigorates qi, strengthens the spleen, and eliminates phlegm and dampness. By strengthening the spleen, it removes dampness from the body at its source, reducing swelling and promoting weight loss. Furthermore, five-finger peach removes dampness without harming the body, strengthens the body's resistance, and invigorates qi without causing heat. In summary, this formula invigorates the spleen and kidneys, eliminates phlegm and removes blood stasis, and lowers lipids and promotes weight loss.

[0011] More specifically, the aforementioned technical solution starts from the traditional Chinese medicine principle of "tonifying the spleen and kidneys, and eliminating excess phlegm and dampness." It aims to promote weight loss and endurance, strengthen the spleen and stomach, nourish yin and kidneys, reduce obesity and lipids, and prolong life. It is formulated with a combination of natural ingredients that are both medicinal and edible, resulting in definite weight loss and lipid-lowering effects, as well as significant nutritional, strengthening, and beautifying effects. Traditional Chinese medicine believes that obese people often have excessive phlegm and dampness, and the pathogenesis is analyzed from the perspective of deficiency of the root and excess of the branch. The root cause is spleen and kidney qi deficiency, leading to impaired water metabolism; the branch cause is the accumulation of phlegm and dampness due to excessive consumption of rich and fatty foods. The medicinal properties are sweet and neutral, without the drawbacks of being too cold or too hot, which could harm the body's vital energy and stomach. It is convenient to take, and long-term use has no adverse side effects, making it a relatively ideal weight loss and health care product.

[0012] As a preferred embodiment of the technical solution of the present invention, the food-medicine composition is prepared from the following raw materials in parts by weight: 15-40 parts of yam, 15-40 parts of red adzuki bean, 15-40 parts of black rice, 15-40 parts of buckwheat, 15-30 parts of hawthorn, 20-40 parts of black sesame, 1-10 parts of tangerine peel, 1-10 parts of winter melon peel, 20-40 parts of poria cocos, and 10-30 parts of five-finger peach.

[0013] As a further preferred embodiment, the food-medicine composition is prepared from the following raw materials: 30 parts yam, 30 parts red adzuki bean, 30 parts black rice, 30 parts buckwheat, 30 parts hawthorn, 30 parts black sesame, 10 parts orange peel, 10 parts winter melon peel, 30 parts poria cocos, and 20 parts five-finger peach.

[0014] Secondly, the present invention also provides a method for preparing the above-mentioned food-medicine homology composition, comprising the following steps: (1) Weigh out the following ingredients by weight: yam, red beans, black rice, buckwheat, hawthorn, and black sesame. Soak them in water, heat them, and then grind them to form a coarse slurry. (2) Activate Lactobacillus acidophilus and Saccharomyces cerevisiae in a mass ratio of 3:1 in a sterile culture medium at 37~40℃. After activation, inoculate the crude slurry with an inoculation amount of 0.5~2% of the crude slurry mass, and then carry out fermentation to obtain fermentation products. (3) Mix the orange peel and winter melon peel and crush them. Then pass them through a 100-200 mesh sieve to obtain ultrafine powder. Extract the poria cocos and five-finger peach separately to obtain poria cocos extract and five-finger peach extract. (4) After mixing the fermentation product, ultrafine powder, Poria cocos extract and five-finger peach extract evenly, adjust the pH value of the system to 4.2~4.8; finally, it is ready by spray gelatinization.

[0015] In the above method, the Poria cocos extract is obtained through a specific method, preferably, the preparation method includes the following steps: S11. After washing, drying, and pulverizing Poria cocos, add it to a eutectic solvent, sonicate, and filter to obtain a primary filtrate and residue. S12. Add the filter residue obtained in step 1 to an aqueous solution containing glycine betaine, sonicate, filter, and obtain the filtrate. S13. Combine the primary filtrate obtained in step S11 and the secondary filtrate obtained in step S12, and then perform filtration, concentration and drying in sequence to obtain Poria cocos extract.

[0016] As a preferred embodiment of the above preparation method, in step S11, the eutectic solvent is composed of choline chloride and glycerol in a molar ratio of 1:2; the ratio of Poria cocos to the eutectic solvent is 1:5~15; the ultrasonic treatment power is 50~100W, and the treatment time is 0.5~4h. In step S12, the concentration of glycine betaine is 0.5~1wt%; the mass ratio of filter residue to aqueous solution is 1:10~20; the ultrasonic treatment power is 50~100W, and the treatment time is 10~60min.

[0017] In the above formula, the extract of *Ficus hirta* is obtained by a specific method. Preferably, the preparation method includes the following steps: S21. After washing, drying and crushing the five-finger peach, add it to an aqueous solution containing Tween 80, soak it, filter it, and obtain pretreated five-finger peach. S22. After the soaking treatment, the five-finger peach is subjected to steam explosion treatment. After the treatment is completed, it is filtered to obtain primary filtrate and filter residue. S23. Add the filter residue obtained in step S22 to an aqueous solution containing citric acid, and then perform ultrasonic treatment. After the treatment is completed, centrifuge to obtain a secondary filtrate. S24. Combine the first filtrate obtained in step S22 and the second filtrate obtained in step S23 to obtain the total extract; finally, freeze-dry to obtain the five-finger peach extract.

[0018] As a preferred embodiment of the above preparation method, in step S21, the concentration of Tween 80 is 0.1~0.5wt%; the mass ratio of *Ficus hirta* to aqueous solution is 1:5~10; the soaking temperature is room temperature, and the treatment time is 4~12h. In step S22, saturated steam is used for steam explosion, the steam explosion pressure is 1.1~1.2MPa, and the pressure maintenance time is 10~30s.

[0019] As a preferred embodiment of the above preparation method, in step S23, the concentration of citric acid is 0.05~0.2wt%, the mass ratio of filter residue to aqueous solution is 1:10~20, the ultrasonic treatment power is 50~100W, and the treatment time is 3~10min.

[0020] Thirdly, the present invention also provides the application of the above-mentioned food-medicine homology composition in the preparation of weight loss products, and different product forms with different effects can be prepared by adding excipients.

[0021] Compared with the prior art, the present invention has the following beneficial effects: (1) The food-medicine composition provided by the present invention is preferably formulated in various ways. It combines the TCM syndrome differentiation and treatment of obesity and is based on the TCM concept of "treating both the symptoms and the root cause". It targets the core pathogenesis of obesity, namely "spleen and kidney deficiency and internal dampness", and achieves fat reduction and lipid reduction by regulating the function of the internal organs, which meets the market demand for a gentle fat reduction solution. At the same time, it avoids the intestinal inflammation such as bloating, intestinal leakage, and allergies caused by consuming grains and beans, which contain anti-nutritional components such as phytic acid, protease inhibitors, and lectins.

[0022] (2) In the food-medicine composition provided by this invention, the orange pith is specifically effective in clearing stagnant qi in the meridians and removing phlegm accumulated under the skin and membranes. Orange pith has always been used as a product to clear the meridians, but it is rarely used to treat obesity. Clinical practice has found that orange pith is a weight-loss drug. In this invention, orange pith was intentionally used to treat obesity and it was found that orange pith can indeed help with weight loss. It has the effects of clearing the meridians and resolving phlegm, regulating qi, and is also a good medicine for preventing and treating cough and qi stagnation. It is a good food therapy product. Winter melon peel has the effect of lowering blood lipids, can dilate blood vessels, clear heat and relieve summer heat, and lower blood pressure. It is a good medicine for weight loss. The principle of weight loss with winter melon peel is to effectively prevent the absorption of fat, remove turbidity and greasiness, prevent fat accumulation in the body, help digestion and fat elimination, and effectively control rebound. Orange pith and winter melon peel contain insoluble dietary fiber, which promotes intestinal peristalsis, removes toxins, and the high fiber content helps with defecation. Through defecation, the purpose of weight loss can be achieved. Five-Finger Peach invigorates Qi and strengthens the spleen, eliminates phlegm and dampness. By strengthening the spleen, it promotes diuresis and removes dampness from the body at its source, thus reducing swelling and slimming. Poria cocos works through a four-dimensional linkage of "draining water, strengthening the spleen, regulating bacteria, and calming the mind," making it especially suitable for those with a weak spleen and dampness-prone, bloated physique. Together with other substances, the two have a good weight loss effect.

[0023] (3) In the food and medicine composition provided by the present invention, the extraction of Poria cocos is obtained by low eutectic solvent extraction, water extraction and ultrasonic treatment; among them, the inventor found through screening that the combination system of choline chloride and glycerol has the best effect; glycine betaine is used in water extraction, which can reduce interfacial tension, promote solvent penetration and effectively improve extraction efficiency, which was also obtained by the inventor after repeated screening.

[0024] (4) In the food and medicine composition provided by the present invention, the extraction of five-finger peach is obtained by soaking, steam explosion and citric acid treatment. The soaking of Tween 80 can initially act on the five-finger peach system, which is convenient for short-term and efficient steam explosion treatment. The use of citric acid can effectively promote the full dissolution of difficult-to-extract substances in the filter residue, shorten the subsequent ultrasonic treatment time and improve the extraction efficiency.

[0025] (5) Grains and legumes contain a lot of anti-nutrients, which can reduce the body's absorption and utilization of nutrients and easily cause nausea, bloating, vomiting, abdominal pain, diarrhea, and leaky intestines. Among these, bloating caused by anti-nutrients is the most common. At the same time, anti-nutrients may have a certain negative impact on the thyroid gland, protein digestion, and mineral absorption. In the preparation process of the food-medicine homology composition provided by this invention, soaking + pre-fermentation + spraying completely destroys the anti-nutrients commonly found in legumes and grains, such as lectins, phytic acid, oxalic acid, tannins, polyphenols, and protease inhibitors, which greatly reduces the stimulation to the gastrointestinal tract. The digestibility of the processed instant powder can be increased to 96% to 100%; it contains almost no phytic acid, which better overcomes the defects of traditional cellulose due to the presence of phytic acid and immunogenicity, avoids inducing intestinal inflammation, and has better safety.

[0026] (6) The food-medicine composition provided by this invention is beneficial for obese individuals with high uric acid levels. Obese people often consume large amounts of meat and fish, and some of them have high uric acid levels. Grains and beans are high-purine foods, and excessive consumption can induce or aggravate gout. Soaking grains and beans in plenty of water allows the beans to absorb water and swell during soaking, loosening their cell structure and dissolving some purines into the soaking water. Heating further breaks down the cell walls of the beans, allowing more purines to dissolve into the broth more quickly. Blanching is much more efficient than simply soaking. Through this combination of soaking, blanching, and discarding the broth, the purine content in beans can be significantly reduced, moving them from the "medium-high purine" category to the "medium-low purine" category, thus making them suitable for moderate consumption. Many obese individuals have high uric acid levels, and this is taken into consideration.

[0027] In summary, the food-medicine homology composition provided by this invention, through the selection of optimal ingredient types and the combination of efficient extraction process, results in a composition with excellent weight loss effect. Detailed Implementation

[0028] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0029] Unless otherwise specified, all raw materials used in this invention can be purchased from ordinary pharmacies and their specifications meet national pharmaceutical standards.

[0030] Lactobacillus acidophilus was CMCC P0002, purchased from Shanghai Xinyi Pharmaceutical Co., Ltd.; Saccharomyces cerevisiae was CNCMI-3799, purchased from Shanyi Food (Shanghai) Co., Ltd.

[0031] It should be noted that, unless otherwise specified, all weight parts mentioned in this invention refer to mass. The weight parts mentioned can be scaled up or down proportionally, and the specific numerical limits do not constitute a strict limitation on the specific amount used.

[0032] Example 1 This embodiment provides a method for preparing Poria cocos extract, comprising the following steps: S11. After washing, drying and pulverizing Poria cocos to 40 mesh, add it to a eutectic solvent (composed of choline chloride and glycerol in a molar ratio of 1:10) at a mass ratio of 1:10, sonicate (80W, 1.5h), filter, and obtain a primary filtrate and filter residue. S12. Add the filter residue obtained in step 1:15 to an aqueous solution containing 0.65wt% glycine betaine, sonicate (80W, 30min), filter, and collect the filtrate. S13. Combine the primary filtrate obtained in step S11 and the secondary filtrate obtained in step S12, and then perform filtration, concentration and drying in sequence to obtain Poria cocos extract.

[0033] Example 2 In this embodiment, a method for preparing a five-finger peach extract is provided, comprising the following steps: S21. Wash, dry, and crush the five-finger peach to 40 mesh. Then, add it to an aqueous solution containing 0.8wt% Tween 80 at a mass ratio of 1:8. Soak the mixture (at room temperature for 8 hours), filter, and obtain pretreated five-finger peach. S22. After the soaking treatment, the five-finger peach is subjected to steam explosion treatment (saturated water steam, steam explosion pressure is 1.15MPa, pressure maintenance time is 20s). After the treatment, it is filtered to obtain primary filtrate and filter residue. S23. Add the filter residue obtained in step S22 to an aqueous solution containing 0.1 wt% citric acid at a mass ratio of 1:15, and then perform ultrasonic treatment (60 W, 5 min). After treatment, centrifuge to obtain a secondary filtrate. S24. Combine the first filtrate obtained in step S22 and the second filtrate obtained in step S23 to obtain the total extract; finally, freeze-dry to obtain the five-finger peach extract.

[0034] Example 3 A food-medicine composition that helps control body fat is prepared from the following ingredients in parts by weight: 30g yam, 30g red adzuki bean, 30g black rice, 30g buckwheat, 30g hawthorn, 30g black sesame, 10g tangerine peel, 10g winter melon peel, 30g Poria cocos, and 20g five-finger peach.

[0035] In this embodiment, a method for preparing a food-medicine homology composition is also provided, comprising the following steps: (1) Weigh out the yam, red beans, black rice, buckwheat, hawthorn and black sesame according to the weight, add water and soak (25℃, 6h), after soaking, put the materials into cold water, heat to boiling, keep boiling for 4min; then grind to 30 mesh to form coarse slurry; (2) Activate Lactobacillus acidophilus and Saccharomyces cerevisiae at a mass ratio of 3:1 in a sterile culture medium at 38°C for 2 hours to ensure that the viable count reaches 10. 8 CFU / mL or higher; after activation, inoculate the coarse slurry at an inoculation rate of 1.2% of the coarse slurry mass, and then carry out fermentation (fermentation at 30℃ for 2 hours, then increase the temperature to 36℃ for 5 hours) to obtain the fermentation product; (3) Mix and pulverize the orange peel and winter melon peel through a 150-mesh sieve to obtain ultrafine powder; add ultrafine powder, Poria cocos extract (prepared according to Example 1 with a dosage of 30g) and Five-finger Peach extract (prepared according to Example 2 with a dosage of 20g) to the fermentation product, mix evenly, and adjust the pH value of the system to 4.5; finally, spray gelatinize (180℃) to obtain the product; the specific size of the spray-formed particles shall be adjusted according to the actual process requirements.

[0036] Example 4 A food-medicine composition that helps control body fat is prepared from the following raw materials in parts by weight: 25g yam, 35g red adzuki bean, 28g black rice, 28g buckwheat, 32g hawthorn, 32g black sesame, 8g orange peel, 8g winter melon peel, 32g Poria cocos, and 22g five-finger peach.

[0037] In this embodiment, a method for preparing a food-medicine homology composition is also provided, comprising the following steps: (1) Weigh out the yam, red beans, black rice, buckwheat, hawthorn and black sesame according to the weight, add water and soak (25℃, 6h), after soaking, put the materials into cold water, heat to boiling, keep boiling for 4min; then grind to 30 mesh to form coarse slurry; (2) Activate Lactobacillus acidophilus and Saccharomyces cerevisiae at a mass ratio of 3:1 in a sterile culture medium at 38°C for 2 hours to ensure that the viable count reaches 10. 8 CFU / mL or higher; after activation, inoculate the coarse slurry at an inoculation rate of 1.2% of the coarse slurry mass, and then carry out fermentation (fermentation at 30℃ for 2 hours, then increase the temperature to 36℃ for 5 hours) to obtain the fermentation product; (3) Powder the orange peel and winter melon peel through a 150-mesh sieve to obtain ultrafine powder; add the ultrafine powder, Poria cocos extract (prepared according to Example 1 with a dosage of 32g) and Five-finger Peach extract (prepared according to Example 2 with a dosage of 22g) to the fermentation product, mix evenly, and adjust the pH value of the system to 4.5; finally, spray gelatinize (180℃) to obtain the product; the specific size of the spray-formed particles shall be adjusted according to the actual process requirements.

[0038] Example 5 A food-medicine composition that helps control body fat is prepared from the following ingredients in parts by weight: 34g yam, 25g red adzuki bean, 24g black rice, 26g buckwheat, 35g hawthorn, 28g black sesame, 11g tangerine peel, 12g winter melon peel, 28g poria cocos, and 18g five-finger peach.

[0039] In this embodiment, a method for preparing a food-medicine homology composition is also provided, comprising the following steps: (1) Weigh out the yam, red beans, black rice, buckwheat, hawthorn and black sesame according to the weight, add water and soak (25℃, 6h), after soaking, put the materials into cold water, heat to boiling, keep boiling for 4min; then grind to 30 mesh to form coarse slurry; (2) Activate Lactobacillus acidophilus and Saccharomyces cerevisiae at a mass ratio of 3:1 in a sterile culture medium at 38°C for 2 hours to ensure that the viable count reaches 10. 8 CFU / mL or higher; after activation, inoculate the coarse slurry at an inoculation rate of 1.2% of the coarse slurry mass, and then carry out fermentation (fermentation at 30℃ for 2 hours, then increase the temperature to 36℃ for 5 hours) to obtain the fermentation product; (3) Powder the orange peel and winter melon peel through a 150-mesh sieve to obtain ultrafine powder; add the ultrafine powder, Poria cocos extract (prepared according to Example 1 with a dosage of 28g) and Five-finger Peach extract (prepared according to Example 2 with a dosage of 18g) to the fermentation product, mix evenly, and adjust the pH value of the system to 4.5; finally, spray gelatinize (180℃) to obtain the product; the specific size of the spray-formed particles shall be adjusted according to the actual process requirements.

[0040] Comparative Example 1 Compared with Example 1, in Comparative Example 1 step S11, the eutectic solvent was replaced with an equal amount of ethanol solvent, and the rest were the same.

[0041] Comparative Example 2 Compared with Example 1, in Comparative Example 2, the use of glycine betaine was omitted in step S12, while the rest were the same.

[0042] Comparative Example 3 Compared with Example 2, in Comparative Example 3, step S21 omits the use of Tween 80, but the rest is the same.

[0043] Comparative Example 4 Compared with Example 2, in Comparative Example 4, step S23, the use of citric acid was omitted, while the rest were the same.

[0044] Comparative Example 5 Compared with Example 3, the use of Poria cocos (i.e., Poria cocos extract) was omitted, and the preparation process was adjusted accordingly.

[0045] Comparative Example 6 Compared with Example 3, the use of five-finger peach (i.e., five-finger peach extract) was omitted, and the preparation process was adjusted accordingly.

[0046] Comparative Example 7 Compared with Example 3, the use of orange pith was omitted, and the preparation process was adjusted accordingly.

[0047] Comparative Example 8 Compared with Example 3, the use of winter melon peel was omitted, and the preparation process was adjusted accordingly.

[0048] Test case The total triterpenoid content in the Poria cocos extracts obtained in Example 1, Comparative Examples 1 and 2 was tested using a vanillin-glacial acetic acid-perchloric acid system, specifically according to existing literature CN119185384A. The test results are shown in Table 1.

[0049] Table 1 Group Extract mass / g Total triterpenoid content / % Example 1 87.5 68.6 Comparative Example 1 80.4 52.3 Comparative Example 2 84.3 58.7 Total triterpenoids in Poria cocos have been shown to improve obesity symptoms. As can be seen from the test results in Table 1, the extraction method provided by this invention yields a higher content of total triterpenoids in the Poria cocos extract, and also results in higher extraction efficiency.

[0050] Furthermore, the total flavonoid content in the extracts of *Ficus hirta* obtained in Example 2, Comparative Examples 3 and 4 was tested. Specific testing methods can be found in existing literature CN101129473A. The test results are shown in Table 2.

[0051] Table 2 Group Extract mass / g Total flavonoid content / % Example 2 82.3 36.9 Comparative Example 3 70.6 32.1 Comparative Example 4 73.8 33.8 As can be seen from Table 2, the extraction method provided in this embodiment of the invention yields a high extraction efficiency and a high content of effective components in the extract of *Ficus hirta*.

[0052] Experimental Example 1 In this experiment, a nutritionally obese rat model was established using a high-fat diet. The rats were then given the prepared food-medicine homology instant powder (i.e., the prepared products) as an intervention and continued to be fed a high-fat diet. The weight loss effect of the food-medicine homology instant powder on nutritionally obese rats was explored by observing obesity-related indicators.

[0053] 1.1 Experimental Materials Animals and rearing conditions: Seventy healthy male SPF-grade SD rats, weighing 170-190g, were kept indoors at 25±1℃ with free access to water. A 12h:12h day and night lighting system was used, and the water was changed 3 times a week.

[0054] Basic feed: 20% wheat flour, 10% dehydrated cabbage (with water removed), 20% soybean flour, 1% yeast, 5% bone meal, 16% corn flour, 16% wheat bran, 10% fish meal, and 2% salt.

[0055] High-fat nutritional feed: 51.8% ordinary basic feed, 20% egg yolk powder, 7% lard, 5% milk powder, 5% white sugar, 20g cod liver oil / kg, 2% peanuts, 5% soybeans, 1% salt, and 0.5% sesame oil.

[0056] Experimental drugs and dosage settings: The dosage of the ready-to-eat powder with medicinal and edible properties prepared in Example 3 and the ready-to-eat powder with medicinal and edible properties prepared in Comparative Examples 5 to 8 was 0.64 g / kg.d.

[0057] 1.2 Experimental Methods The experimental animals were randomly divided into 7 groups (normal control group, model control group, Example 3 group, comparative example 5 group, comparative example 6 group, comparative example 7 group, and comparative example 8 group), with 10 animals in each group. The normal control group was fed with ordinary feed, while the other groups were fed with high-fat feed for 6 consecutive weeks. Starting from the 7th week, Example 3 group, Comparative example 5 group, Comparative example 6 group, Comparative example 7 group, and Comparative example 8 group were given the corresponding ready-to-eat powder of medicinal and edible homology, while the normal control group and model control group were given an equal volume of distilled water. The drugs were administered by gavage at a dose of 1 mL / 100 g, once a day for 6 consecutive weeks. The normal control group continued to be fed with ordinary feed, while the model control group and the drug-treated groups were fed with high-fat feed.

[0058] 1.3 Indicator Detection Methods 1.3.1 Weight, body length, and Lee's Index Starting from week 6, the rats' body weight (g) was measured weekly, and the average value for each group was recorded. After 12 weeks of continuous feeding, the rats were fasted but allowed free water for 12 hours. Under ether anesthesia, the rats' body length (from nose tip to anus, cm) was measured, and Lee's index was calculated. Lee's index is an indicator for assessing the degree of obesity in rats; Lee's index = body weight. 1 / 3 (g)×1000 / body length (cm).

[0059] 1.3.2 Fat weight and fat-to-body ratio After feeding continuously for 12 weeks, the animals were fasted but allowed to drink water for 12 hours. They were then euthanized by dislocating their cervical vertebrae. The fat around the kidneys and genitals was dissected and its wet weight was measured. The fat-to-body ratio was calculated as: fat weight (g) / body weight (100g).

[0060] 1.4 Experimental Results 1.4.1 Effects on body weight of nutritionally obese rats The results of rat weight are shown in Table 3. Compared with the model group, the weight of rats in the food-medicine homology instant powder group was significantly lower than that of the model group at weeks 10 and 12.

[0061] Table 3 Effects on body weight of nutritionally obese rats Group Number of animals / N Week 6 Week 8 Week 10 Week 12 normal control group 10 221.7±15.7 258.5±14.9 275.8±22.4 295.4±25.7 Model control group 10 256.5 ± 16.2 1 ]] 315.1±28.9 355.6±41.1 381.5±49.3 Example 3 Group 10 258.3 ± 15.1 1 ]] 262.2 ± 20.1 2 ]] 286.0 ± 25.4 2 ]] 309.2 ± 31.5 2 ]] Comparative Example 5 Groups 10 261.5 ± 17.5 1 ]]> 288.3±23.2 315.2±32.9 346.0±35.8 Comparative Example 6 Groups 10 260.2 ± 16.8 1 ]] 280.6±22.8 318.3±29.2 349.7±33.1 Comparative Example 7 Groups 10 262.1 ± 17.9 1 ]] 278.3±20.1 320.0±27.1 338.5±37.6 Comparative Example 8 Groups 10 257.0 ± 16.3 1 ]] 275.2±19.7 317.0±27.4 346.4±38.4 Note: Superscript 1 indicates P < 0.05 compared with the normal group, and superscript 2 indicates P < 0.05 compared with the model group.

[0062] 1.4.2 Effects on Lee's Index in Nutritionally Obese Rats The results are shown in Table 4. Compared with the normal control group, the Lee's index of rats in the model control group was significantly higher than that in the normal group (P<0.05); compared with the model control group, the Lee's index of rats in the food-medicine homology instant powder group was significantly lower (P<0.05). There was no significant difference in body length between rats in the model control group and rats in the food-medicine homology instant powder group (P>0.05).

[0063] Table 4. Effects on Lee's Index in Nutritionally Obese Rats Group Number of animals N Lee's Index normal control group 10 309.88±12.84 Model control group 10 322.92 ± 7.13 1 ]] Example 3 Group 10 <![CDATA[306.39±8.63 2 ]]> Comparative Example 5 Groups 10 315.72±8.89 Comparative Example 6 Groups 10 312.88±9.46 Comparative Example 7 Groups 10 310.92±9.53 Comparative Example 8 Groups 10 314.84±9.41 Note: Superscript 1 indicates P < 0.05 compared with the normal group, and superscript 2 indicates P < 0.05 compared with the model group.

[0064] 1.4.3 Effect on the fat body ratio of nutritionally obese rats The results are shown in Table 5 below. Compared with the normal control group, the fat weight and fat-body ratio of the animals in the model control group were significantly increased (P<0.05); compared with the model control group, the fat weight and fat-body ratio of the example group were significantly decreased (P<0.05).

[0065] Table 5 Effects on fat body ratio in nutritionally obese rats Group Number of animals N Fat ratio normal control group 10 1.76±0.54 Model control group 10 <![CDATA[3.37±1.42 1 ]]> Example 3 Group 10 <![CDATA[2.35±0.44 2 ]]> Comparative Example 5 Groups 10 2.37±0.50 Comparative Example 6 Groups 10 2.38±0.52 Comparative Example 7 Groups 10 2.41±0.46 Comparative Example 8 Groups 10 <![CDATA[2.36±0.48 2 ]]> Note: Superscript 1 indicates P < 0.05 compared with the normal control group; superscript 2 indicates P < 0.05 compared with the model control group.

[0066] Experimental Example 2 The company is recruiting individuals with a BMI > 24.0 kg / m². 2Forty overweight volunteers aged 18-65 years with no other underlying diseases participated in the trial. They consumed 6g of the ready-to-eat powder prepared in Example 3 daily for 60 consecutive days (discontinue immediately if adverse reactions occur). Otherwise, they maintained normal sleep and diet. Weight changes before and after the trial were recorded. The preliminary criteria for product effectiveness were as follows: no weight change / weight gain indicated product ineffectiveness; 1%-5% weight loss indicated moderate product effectiveness; 5%-10% weight loss indicated significant product effectiveness; and greater than 10% weight loss indicated very significant product effectiveness. The weight changes of the volunteers before and after the trial are shown in Table 6 below.

[0067] Table 6 invalid generally Significant Very significant Experimental group (number of participants) 2 13 17 8 Experimental group (proportion) 5% 32.5% 42.5% 20% As can be seen from the test results in Table 6, the weight loss effectiveness of the product prepared in this embodiment is as high as 95%.

[0068] The applicant declares that the technical solution of this invention is illustrated through the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of individual raw materials in the product of this invention, additions of auxiliary components, and selection of specific methods, all fall within the protection scope and disclosure scope of this invention.

Claims

1. A food-grade medicinal composition that helps control body fat, characterized in that, The product is prepared by weight from the following raw materials: 10-50 parts yam, 10-50 parts red adzuki bean, 10-50 parts black rice, 10-50 parts buckwheat, 10-30 parts hawthorn, 20-50 parts black sesame, 1-20 parts orange peel, 1-20 parts winter melon peel, 20-50 parts poria cocos, and 10-40 parts five-finger peach.

2. The medicinal and edible composition according to claim 1, which helps control body fat, is characterized in that... The product is prepared by weight from the following raw materials: 15-40 parts yam, 15-40 parts red adzuki bean, 15-40 parts black rice, 15-40 parts buckwheat, 15-30 parts hawthorn, 20-40 parts black sesame, 1-10 parts orange peel, 1-10 parts winter melon peel, 20-40 parts poria cocos, and 10-30 parts five-finger peach.

3. The food-medicine composition according to claim 1, which helps control body fat, is characterized in that... The product is prepared by weight from the following raw materials: 30 parts yam, 30 parts red adzuki bean, 30 parts black rice, 30 parts buckwheat, 30 parts hawthorn, 30 parts black sesame, 10 parts orange peel, 10 parts winter melon peel, 30 parts poria cocos, and 20 parts five-finger peach.

4. A method for preparing the medicinal and edible composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: (1) Weigh out the following ingredients by weight: yam, red beans, black rice, buckwheat, hawthorn, and black sesame. Soak them in water, heat them, and then grind them to form a coarse slurry. (2) Activate Lactobacillus acidophilus and Saccharomyces cerevisiae in a mass ratio of 3:1 in a sterile culture medium at 37~40℃. After activation, inoculate the crude slurry with an inoculation amount of 0.5~2% of the crude slurry mass, and then carry out fermentation to obtain fermentation products. (3) Mix the orange peel and winter melon peel and crush them. Then pass them through a 100-200 mesh sieve to obtain ultrafine powder. Extract the poria cocos and five-finger peach separately to obtain poria cocos extract and five-finger peach extract. (4) After mixing the fermentation product, ultrafine powder, Poria cocos extract and five-finger peach extract evenly, adjust the pH value of the system to 4.2~4.8; finally, it is ready by spray gelatinization.

5. The method for preparing the food-medicine homology composition according to claim 4, characterized in that, The preparation of the Poria cocos extract includes the following steps: S11. After washing, drying, and pulverizing Poria cocos, add it to a eutectic solvent, sonicate, and filter to obtain a primary filtrate and residue. S12. Add the filter residue obtained in step 1 to an aqueous solution containing glycine betaine, sonicate, filter, and obtain the filtrate. S13. Combine the primary filtrate obtained in step S11 and the secondary filtrate obtained in step S12, and then perform filtration, concentration and drying in sequence to obtain Poria cocos extract.

6. The method for preparing the food-medicine homology composition according to claim 5, characterized in that, In step S11, the eutectic solvent is composed of choline chloride and glycerol in a molar ratio of 1:2; the ratio of Poria cocos to the eutectic solvent is 1:5~15; the ultrasonic treatment power is 50~100W, and the treatment time is 0.5~4h. In step S12, the concentration of glycine betaine is 0.5~1wt%; the mass ratio of filter residue to aqueous solution is 1:10~20; the ultrasonic treatment power is 50~100W, and the treatment time is 10~60min.

7. The method for preparing the food-medicine homology composition according to claim 4, characterized in that, The preparation of the Five-Finger Peach Extract includes the following steps: S21. After washing, drying and crushing the five-finger peach, add it to an aqueous solution containing Tween 80, soak it, filter it, and obtain pretreated five-finger peach. S22. After the soaking treatment, the five-finger peach is subjected to steam explosion treatment. After the treatment is completed, it is filtered to obtain primary filtrate and filter residue. S23. Add the filter residue obtained in step S22 to an aqueous solution containing citric acid, and then perform ultrasonic treatment. After the treatment is completed, centrifuge to obtain a secondary filtrate. S24. Combine the first filtrate obtained in step S22 and the second filtrate obtained in step S23 to obtain the total extract; finally, freeze-dry to obtain the five-finger peach extract.

8. The method for preparing the food-medicine homology composition according to claim 7, characterized in that, In step S21, the concentration of Tween 80 is 0.1~0.5wt%; the mass ratio of Prunus armeniaca to aqueous solution is 1:5~10; the soaking temperature is room temperature, and the treatment time is 4~12h. In step S22, saturated steam is used for steam explosion, the steam explosion pressure is 1.1~1.2MPa, and the pressure maintenance time is 10~30s.

9. A food-medicine composition according to claim 7 that helps control body fat, characterized in that, In step S23, the concentration of citric acid is 0.05~0.2wt%, the mass ratio of filter residue to aqueous solution is 1:10~20, the ultrasonic treatment power is 50~100W, and the treatment time is 3~10min.

10. The use of the medicinal and edible composition according to any one of claims 1 to 9 in the preparation of a weight loss product.