Capsule medicine for treating hyperlipemia as well as preparation method and application thereof
By preparing a capsule containing egg extract, tea polyphenols, and turmeric extract, the shortcomings of existing drugs in lowering and eliminating triglycerides and cholesterol have been overcome, achieving significant lipid-lowering effects and rapid elimination, thus improving the efficacy of treating hyperlipidemia.
Patent Information
- Application Number
- CN202511943520.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-22
- Publication Date
- 2026-01-23
AI Technical Summary
Existing medications for treating hyperlipidemia are not very effective in lowering triglyceride and cholesterol levels, or the reduced levels are not eliminated in time, resulting in poor treatment outcomes.
This capsule drug, with egg extract, tea polyphenols, sophora flavescens extract and turmeric extract as the main ingredients, is prepared by processes such as ultrasonic extraction, vacuum concentration, vacuum drying and supercritical CO2 extraction, which improves antioxidant capacity and accelerates the excretion of triglycerides and cholesterol.
It significantly reduces the levels of triglycerides and cholesterol in plasma, enhances the antioxidant capacity of liver VLDL, superoxide dismutase, and glutathione peroxidase, inhibits fat production, and promotes the rapid excretion of triglycerides and cholesterol, thus achieving highly effective treatment for hyperlipidemia.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of medical drugs, in particular to a capsule medicine for treating hyperlipidemia and a preparation method and application thereof. BACKGROUND
[0002] Hyperlipidemia, also known as hyperlipidemia or dyslipidemia, generally refers to the increase of triglyceride and cholesterol in blood plasma. Egg yolk lecithin is obtained by separation from egg yolk and belongs to animal embryo phospholipid, which contains essential nutrients for human body including trace elements. Egg yolk lecithin can emulsify cholesterol into extremely fine particles and then be utilized by tissues through blood vessel wall, which can reduce the risk of cholesterol deposition in blood plasma. However, the reduced contents of triglyceride and cholesterol need to be reduced, and the reasons are twofold, the first one is that the reduced amount is small, and the second one is that the reduced triglyceride and cholesterol are not discharged in time.
[0003] Therefore, the present application provides a capsule medicine for treating hyperlipidemia and a preparation method and application thereof to solve the above problems. SUMMARY
[0004] In view of the above-mentioned defects in the prior art, the present application provides a capsule medicine for treating hyperlipidemia and a preparation method and application thereof.
[0005] To achieve the above object, the present application is implemented by the following technical solutions: A capsule medicine for treating hyperlipidemia is prepared from the following raw materials in the following weight percentages: egg extract 58-69%, tea polyphenol 8.3-10.3%, Sophora flavescens extract 13.2-18.6%, and turmeric extract 7.1-13.1%. The preparation method of the egg extract comprises the following steps: Step one: after disinfection, the fresh eggs are broken, and the yolk and the egg white are separated, the yolk is uniformly scattered, and the yolk liquid is obtained; Step two: the yolk liquid is added to an ultrasonic extraction machine, and 1:3.5-4.5 times volume of 90-95% ethanol solution is added to the ultrasonic extraction machine, pulse ultrasonic assisted extraction is carried out for 15-30 min, and then the mixture is separated by centrifugation or filtration, repeated extraction is carried out, and the supernatant is obtained; Step three: the supernatant is placed at 40-50℃ under reduced pressure to concentrate to a thick paste, and then the thick paste is placed at 50-65℃ under vacuum drying, and the crude extract is obtained; Step four: the crude extract is pulverized to fine particles by airflow mill under nitrogen protection, and then supercritical CO2 extraction is carried out, and the egg extract is obtained.
[0006] Further, the egg extract is egg yolk lecithin, and the purity is 96.3-97.5%.
[0007] Further, the pulse ultrasonic frequency is 20-200 KHz, the extraction temperature is 40-70 DEG C, and the pulse interval is 3-5 s.
[0008] Further, the diameter of the fine particles is 20-28 mu m.
[0009] Further, the content of vitamin E in the Sophora flavescens extract is not less than 10%.
[0010] Further, the mass concentration of tea polyphenol is 0.1-0.3%.
[0011] Further, the content of zingiberene in the turmeric extract is not less than 35%.
[0012] The application provides a preparation method of a capsule medicine for treating hyperlipidemia, and comprises the following steps: Step a, the prescription amount of egg extract, tea polyphenol, Sophora flavescens extract and turmeric extract are weighed and added into a blender to obtain a mixture; Step b, the mixture is sieved through a 100-mesh sieve; Step c, the sieved material is put into a multidirectional motion mixer, and then is filled into a capsule after uniform mixing.
[0013] The application provides application of the capsule medicine in the medicine for treating hyperlipidemia.
[0014] Compared with the prior art, the application has the beneficial effects that the egg extract improves the antioxidant indexes of liver VLDL, superoxide dismutase, glutathione peroxidase and total antioxidant capacity, reduces the accumulation of plasma triglyceride and total cholesterol, and the tea polyphenol and Sophora flavescens extract help to improve the activity of the egg extract, further improve the effect of the egg extract, meanwhile, the tea polyphenol can inhibit the generation of fat and effectively reduce the energy accumulation, in addition, the turmeric extract helps to accelerate the discharge of the triglyceride and total cholesterol after removal, and realizes the treatment of hyperlipidemia. DETAILED DESCRIPTION
[0015] To make the purpose, technical scheme and advantages of the embodiments of the application clearer, the technical scheme in the embodiments of the application will be described clearly and completely below in combination with the embodiments of the application. Obviously, the described embodiments are part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the application.
[0016] Embodiment 1: a capsule medicine for treating hyperlipidemia, which is prepared from the following raw materials in percentage by weight: egg extract 58%, tea polyphenol 10.3%, sophora flavescens extract 18.6%, and curcuma longa extract 13.1%; The method for preparing the egg extract comprises the following steps: Step 1: a sterilized fresh egg is broken, and the yolk and the albumen are separated, and the yolk is uniformly scattered to obtain yolk liquid; Step 2: the yolk liquid is added into an ultrasonic extraction machine, and 1:3.5 times volume of 93% ethanol solution by mass fraction is added into the ultrasonic extraction machine, and the yolk liquid is extracted for 28 minutes under the assistance of pulse ultrasonic wave, and then the mixture is separated by centrifugation or filtration, and the supernatant is obtained by repeated extraction; Step 3: the supernatant is concentrated into thick paste at 40℃ under reduced pressure, and then the thick paste is vacuum dried at 58℃ to obtain the crude extract; Step 4: the crude extract is pulverized into fine particles under the protection of nitrogen by using an airflow mill, and then the egg extract is obtained by supercritical CO2 extraction.
[0017] The egg extract is egg yolk lecithin, and the purity is 96.3%.
[0018] The pulse ultrasonic wave frequency is 200KHz, the extraction temperature is 65℃, and the pulse interval is 3s.
[0019] The diameter of the fine particles is 28μm.
[0020] The content of vitamin E in the sophora flavescens extract is 12%.
[0021] The mass concentration of the tea polyphenol is 0.1%.
[0022] The content of zingiberene in the curcuma longa extract is 35%.
[0023] The application provides a preparation method of a capsule medicine for treating hyperlipidemia, which comprises the following steps: Step a: the prescription amount of egg extract, tea polyphenol, sophora flavescens extract and curcuma longa extract is weighed and added into a blender to obtain a mixture; Step b: the mixture is sieved through a 100-mesh sieve; Step c: the sieved material is put into a multidirectional motion mixer, and then is filled into capsules after being uniformly mixed.
[0024] Embodiment 2: a capsule medicine for treating hyperlipidemia, which is prepared from the following raw materials in percentage by weight: egg extract 65%, tea polyphenol 9.5%, sophora flavescens extract 13.2%, and curcuma longa extract 12.3%; The method for preparing the egg extract comprises the following steps: Step one: the sterilized fresh egg is broken, the yolk and the albumen are separated, the yolk is uniformly beaten to obtain yolk liquid; Step two: the yolk liquid is added into an ultrasonic extractor, 1:4.5 times volume of 90% mass fraction ethanol solution is added into the ultrasonic extractor, pulse ultrasonic wave is used for auxiliary extraction for 15 min, then the mixture is separated by centrifugation or filtration, and repeated extraction is carried out to obtain supernatant; Step three: the supernatant is placed at 50℃ under reduced pressure and concentrated into thick paste, then the thick paste is placed at 50℃ under vacuum drying, and a crude extract is obtained; Step four: the crude extract is pulverized into fine particles under nitrogen protection by using an airflow mill, then supercritical CO2 extraction is carried out, and an egg extract is obtained.
[0025] The egg extract is egg yolk lecithin, and the purity is 97.5%.
[0026] The pulse ultrasonic wave frequency is 20KHz, the extraction temperature is 40℃, and the pulse interval is 5 s.
[0027] The diameter of the fine particles is 20μm.
[0028] The content of vitamin E in the Sophora flavescens extract is 13%.
[0029] The mass concentration of tea polyphenol is 0.3%.
[0030] The content of zingiberene in the turmeric extract is 38%. The application provides a preparation method of a capsule medicine for treating hyperlipidemia. Step a, egg extract, tea polyphenol, Sophora flavescens extract and turmeric extract are weighed according to the prescription amount, added into a blender, and a mixture is obtained; Step b: the mixture is sieved through a 100 mesh sieve; Step c: the sieved material is put into a multidirectional motion mixer, uniformly mixed and then loaded into a capsule.
[0031] Example 3: a capsule medicine for treating hyperlipidemia is prepared from the following weight percentage of raw materials: egg extract 69%, tea polyphenol 8.3%, Sophora flavescens extract 15.6% and turmeric extract 12.3%. The egg extract preparation method comprises the following steps: Step one: the sterilized fresh egg is broken, the yolk and the albumen are separated, the yolk is uniformly beaten to obtain yolk liquid; Step two: the yolk liquid is added into an ultrasonic extractor, 1:4.2 times volume of 95% mass fraction ethanol solution is added into the ultrasonic extractor, pulse ultrasonic wave is used for auxiliary extraction for 24 min, then the mixture is separated by centrifugation or filtration, and repeated extraction is carried out to obtain supernatant; Step three: the supernatant is concentrated to a thick paste at 42℃ under reduced pressure, and the thick paste is vacuum dried at 65℃ to obtain the crude extract; Step four: the crude extract is ground into fine particles by a jet mill under nitrogen protection, and then supercritical CO2 extraction is performed to obtain the egg extract.
[0032] The egg extract is egg yolk lecithin, and the purity is 96.5%.
[0033] The pulse ultrasonic frequency is 80KHz, the extraction temperature is 70℃, and the pulse interval is 5s.
[0034] The fine particle diameter is 23μm.
[0035] The content of vitamin E in the Sophora flavescens extract is 10%.
[0036] The mass concentration of tea polyphenol is 0.1%.
[0037] The content of zingiberene in the turmeric extract is 39% The application provides a preparation method of a capsule medicine for treating hyperlipidemia. Step a: the prescription amount of egg extract, tea polyphenol, Sophora flavescens extract and turmeric extract is weighed and added to a blender to obtain a mixture; Step b: the mixture is sieved through a 100 mesh sieve; Step c: the sieved material is put into a multi-directional motion mixer, uniformly mixed and then loaded into a capsule.
[0038] Example 4: a capsule medicine for treating hyperlipidemia is prepared from the following weight percentage of raw materials: egg extract 66%, tea polyphenol 9.8%, Sophora flavescens extract 13.9% and turmeric extract 10.3%. The egg extract preparation method comprises the following steps: Step one: after disinfection, the fresh egg is broken, the yolk and the egg white are separated, and the yolk is uniformly beaten to obtain yolk liquid; Step two: the yolk liquid is added to an ultrasonic extraction machine, and 1:3.9 times the volume of 91% mass fraction ethanol solution is added to the ultrasonic extraction machine, pulse ultrasonic assisted extraction is performed for 30min, and then the mixture is separated by centrifugation or filtration, and repeated extraction is performed to obtain supernatant; Step three: the supernatant is concentrated to a thick paste at 42℃ under reduced pressure, and the thick paste is vacuum dried at 65℃ to obtain the crude extract; Step four: the crude extract is ground into fine particles by a jet mill under nitrogen protection, and then supercritical CO2 extraction is performed to obtain the egg extract.
[0039] The egg extract is egg yolk lecithin, and the purity is 96.9%.
[0040] The pulse ultrasonic frequency is 120 KHz, the extraction temperature is 50 DEG C, and the pulse interval is 4 s.
[0041] The diameter of the fine particles is 25 mu m.
[0042] The content of vitamin E in the sophora extract is 14%.
[0043] The mass concentration of tea polyphenol is 0.1%.
[0044] The content of zingiberene in the turmeric extract is 40%. The application provides a preparation method of a capsule medicine for treating hyperlipidemia. Step a, the prescription amount of egg extract, tea polyphenol, sophora extract and turmeric extract is weighed and added into a blender to obtain a mixture; Step b, the mixture is sieved through a 100 mesh sieve; Step c, the sieved material is put into a multi-directional motion mixer, and then is filled into capsules after uniform mixing.
[0045] Example 5: a capsule medicine for treating hyperlipidemia is prepared from the following raw materials in percentage by weight: egg extract 65%, tea polyphenol 9.4%, sophora extract 17.7% and turmeric extract 7.9%. The egg extract preparation method comprises the following steps: Step one: after disinfection, the fresh egg is broken, the yolk and the egg white are separated, the yolk is uniformly beaten and scattered to obtain yolk liquid; Step two: the yolk liquid is added into an ultrasonic extraction machine, 1:3.7 times volume of 92% mass fraction ethanol solution is added into the ultrasonic extraction machine, pulse ultrasonic is used for auxiliary extraction for 21 min, then the mixture is separated by centrifugation or filtration, and repeated extraction is carried out to obtain supernatant; Step three: the supernatant is placed at 48 DEG C and concentrated into thick paste under reduced pressure, then the thick paste is placed at 54 DEG C and vacuum dried to obtain a crude extract; Step four: the crude extract is pulverized into fine particles by an airflow mill under nitrogen protection, and then is extracted by supercritical CO2 to obtain the egg extract.
[0046] The egg extract is egg yolk lecithin, and the purity is 97.2%.
[0047] The pulse ultrasonic frequency is 160 KHz, the extraction temperature is 62 DEG C, and the pulse interval is 3 s.
[0048] The diameter of the fine particles is 27 mu m.
[0049] The content of vitamin E in the Sophora flavescens extract is 15%.
[0050] The mass concentration of tea polyphenol is 0.1%.
[0051] The content of zingiberene in the Curcuma longa extract is 36% The application provides a preparation method of a capsule medicine for treating hyperlipidemia. Step a, the prescription amount of egg extract, tea polyphenol, Sophora flavescens extract and Curcuma longa extract is weighed and added into a blender to obtain a mixture; Step b, the mixture is sieved through a 100-mesh sieve; Step c, the sieved material is put into a multi-directional motion mixer, and then is uniformly mixed and loaded into a capsule.
[0052] Comparative Example 1: Compared with Example 1, Comparative Example 1 does not add tea polyphenol.
[0053] Comparative Example 2: Compared with Example 1, Comparative Example 2 does not add Sophora flavescens extract.
[0054] Comparative Example 3: Compared with Example 1, Comparative Example 3 does not add Curcuma longa extract.
[0055] Comparative Example 4: Compared with Example 1, Comparative Example 4 does not add tea polyphenol, Sophora flavescens extract and Curcuma longa extract.
[0056] Experimental Example: Blood lipid content experiment Tested sample: The capsule medicines prepared in Examples 1-5 and Comparative Examples 1-4.
[0057] Test method: 35 male rats with a weight of 160-180 g are adaptively fed for 5 days, then are randomly divided into 7 groups according to the weight and the body layer by using a random number table, with 5 rats in each group; for 19 days in succession, on the 20th day, the rats are anesthetized with 25% urethane (0.4 ml / 100 g), blood is collected from the abdominal aorta, serum is separated by centrifugation, and the content of triglyceride TG (mmol / L) and cholesterol CHO (mmol / L) is determined, and the test results are as follows.
[0058]
[0059] As shown in the above table, the content of triglyceride TG of Examples 1-5 is 0.45-0.56 mmol / L, the content of cholesterol CHO is 3.73-4.12 mmol / L, the content of triglyceride and cholesterol is low; the content of triglyceride TG of Comparative Examples 1-4 is 0.76-0.85 mmol / L, the content of cholesterol CHO is 5.23-6.14 mmol / L, the content of triglyceride and cholesterol is high. The egg extract improves the antioxidant indexes of liver VLDL, superoxide dismutase, glutathione peroxidase, total antioxidant capacity, reduces the accumulation of plasma triglyceride, total cholesterol and the like, the tea polyphenol and the sophora extract help to improve the activity of the egg extract, further improve the effect of the egg extract, meanwhile, the tea polyphenol can inhibit the generation of fat, effectively reduce the energy accumulation, in addition, the curcuma extract helps to accelerate the discharge of the triglyceride and total cholesterol after the clearance, realizes the treatment of hyperlipidemia.
[0060] The application provides application of a capsule medicine in treatment of hyperlipidemia.
[0061] The above examples are only used to illustrate the technical solutions of the present application, but not limit the same; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that the technical solutions recorded in the foregoing examples can be modified, or some technical features can be replaced by equivalents; and these modifications or replacements will not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.
Claims
1. A capsule-form drug for treating hyperlipidemia, characterized in that, The egg extract is prepared from the following raw materials in the following weight percentages: egg extract 58-69%, tea polyphenol 8.3-10.3%, sophora flavescens extract 13.2-18.6%, and curcuma longa extract 7.1-13.1%; The egg extract preparation method comprises the following steps: Step one: after sterilization, the fresh egg is broken, the yolk and the egg white are separated, the yolk is uniformly beaten, and the yolk liquid is obtained; Step two: the yolk liquid is added to the ultrasonic extraction machine, 1:3.5-4.5 times the volume of 90-95% ethanol solution is added to the ultrasonic extraction machine, pulse ultrasonic assisted extraction is carried out for 15-30 min, then the mixture is separated by centrifugation or filtration, repeated extraction is carried out, and the supernatant is obtained; Step three: the supernatant is concentrated to a thick paste at 40-50°C under reduced pressure, the thick paste is vacuum dried at 50-65°C, and a crude extract is obtained; Step four: the crude extract is pulverized to fine particles by airflow milling under nitrogen protection, then supercritical CO2 extraction is carried out, and an egg extract is obtained.
2. The capsule drug for treating hyperlipidemia according to claim 1, wherein The egg extract is egg yolk lecithin, and the purity is 96.3-97.5%.
3. The capsule drug for treating hyperlipidemia according to claim 2, wherein The pulse ultrasonic frequency is 20-200 KHz, the extraction temperature is 40-70°C, and the pulse interval is 3-5 s.
4. The capsule drug for treating hyperlipidemia according to claim 3, wherein The fine particle diameter is 20-28 μm.
5. The capsule pharmaceutical for treating hyperlipidemia according to claim 4, wherein The content of vitamin E in the sophora flavescens extract is not less than 10%.
6. The capsule pharmaceutical for treating hyperlipidemia according to claim 5, wherein The mass concentration of tea polyphenol is 0.1-0.3%.
7. The capsule pharmaceutical for treating hyperlipidemia according to claim 6, wherein The content of zingiberene in the curcuma longa extract is not less than 35%.
8. The capsule pharmaceutical for treating hyperlipidemia according to claim 7, wherein 。 9. Use of a capsule medicament in the manufacture of a medicament for the treatment of hyperlipidemia, characterized in that, The capsule medicine is the capsule medicine of claim 7.