Novel spray freeze-drying system

Abstract

The invention belongs to the technical field of pharmacy, and discloses a novel spray freeze-drying system which comprises a granulation unit, a spray freeze-drying unit and a drying unit, the granulation unit comprises a freezing chamber and a liquid medicine atomization assembly, and the liquid medicine atomization assembly atomizes raw material medicine liquid and sends the raw material medicine liquid into the freezing chamber to be frozen into ice crystals; the particle collecting and drying unit comprises a cyclone separator, an air blower and a freeze dryer, the cyclone separator is connected with the freezing chamber, the air blower is connected to the cyclone separator, the air blower pumps ice crystals in the freezing chamber and sends the ice crystals into the cyclone separator, and after the cyclone separator collects quantitative ice crystals, the freeze dryer is used for freeze-drying the ice crystals in the freezing chamber. Transferring to a freeze dryer for vacuum drying to obtain dry powder. According to the novel spray freeze-drying system, continuous operation from atomization freezing to collection drying is achieved, the problems of particle aggregation and thermal degradation in traditional spray freeze-drying are solved, the activity retention rate of biological macromolecular drugs is increased, and meanwhile the overall process efficiency is improved.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical technology, and more specifically, relates to a novel spray freeze-drying system. Background Technology

[0002] Biological macromolecules, such as proteins, peptides, and nucleic acids, hold immense potential in disease treatment. However, the formulation development of these drugs faces numerous challenges. Traditional administration methods, such as injection, suffer from poor patient compliance and require specialized medical personnel for administration. Pulmonary administration, as a novel approach, offers advantages such as direct drug delivery to the lungs, rapid onset of action, and minimal systemic side effects, effectively improving patient compliance and treatment efficacy.

[0003] Currently, the main preparation methods for dry powder inhalation formulations include air jet milling, spray drying, spray freeze-drying, and supercritical fluid drying. Air jet milling is the mainstream preparation method for commercially available inhalation formulations. However, because the milling process releases heat, thermally unstable drugs (such as proteins and peptides) are prone to denaturation or degradation. Spray drying technology has the advantages of short drying time, high powder yield, low damage to active ingredients, and good powder uniformity. However, thermally unstable drugs are not suitable for granulation using spray drying technology. Spray freeze-drying technology is suitable for drying biopharmaceutical drugs. Spray freeze-drying involves spraying water-soluble drugs into a refrigerant, where the drug droplets rapidly condense into ice crystals, and then drying under vacuum. However, traditional spray freeze-drying involves spraying the drug solution into a refrigerant, which can easily cause refrigerant boiling, producing the Leidenfrost effect. An insulating gas layer forms on the droplet surface, resulting in slow freezing inside the particles and easy agglomeration of the particles. Summary of the Invention

[0004] To achieve the above objectives, the present invention discloses a novel spray freeze-drying system, comprising:

[0005] The granulation unit includes a freezing chamber and a drug atomization component. The drug atomization component atomizes the raw drug solution and sends it into the freezing chamber to freeze it into ice crystals.

[0006] The particle collection and drying unit includes a cyclone separator, a blower, and a freeze dryer. The cyclone separator is connected to the freeze chamber, and the blower is connected to the cyclone separator. The blower draws ice crystals out of the freeze chamber and sends them to the cyclone separator. After the cyclone separator collects a certain amount of ice crystals, it is transferred to the freeze dryer for vacuum drying to obtain dry powder.

[0007] Preferably, the freezing chamber includes a freezing chamber and a refrigeration chamber. The refrigeration chamber surrounds the side of the freezing chamber and the two are connected by an auxiliary diversion pipe. The refrigeration chamber is filled with refrigerant. The liquid atomizing component is installed at the top of the freezing chamber. The inlet end of the cyclone separator extends into the refrigeration chamber through a quick-release pipe and is connected to the bottom end of the freezing chamber.

[0008] Preferably, the liquid atomization assembly includes a liquid bottle, a peristaltic pump, and an atomizing nozzle connected in sequence. The atomizing nozzle is installed at the top of the freezing chamber, and the compressed gas cylinder is connected to the atomizing nozzle through a valved pipeline.

[0009] Preferably, the atomizing nozzle is a dual-fluid spray head or a vibrating screen spray head.

[0010] Preferably, the freezing chamber is cone-shaped, and a cooling coil is spirally wound on the freezing chamber. The air inlet end of the cooling coil is connected to the inlet located at the top of the freezing chamber, and the air outlet end of the cooling coil is close to the bottom of the freezing chamber.

[0011] Preferably, the particle collection and drying unit further includes:

[0012] The chamber has several sets of particle collection and drying units arranged in an array. The top of the chamber has a pre-reserved upper interface, through which the cyclone separator can be quickly connected to the blower or freeze dryer. The side of the chamber has a pre-reserved side interface, through which the cyclone separator can be quickly connected to the freezer.

[0013] The heat exchange coil is spirally wound on the cyclone separator, which can realize the temperature adjustment of the cyclone separator from -50℃ to 50℃.

[0014] The heat exchanger is located inside the chamber and is connected to the heat exchange coil via a capillary tube. A dryer filter is installed on the capillary tube.

[0015] Preferably, the vibrating screen spray head includes a liquid cavity area, an atomization area, and an outlet area distributed from top to bottom therein. The vibrating screen is located in the atomization area near the liquid cavity area. The spray head electrode is installed on the outer wall of the atomization area and is electrically connected to the controller. The flexible heating element is wrapped around the outer wall of the outlet area and is electrically connected to the controller. The thermocouple is inserted into the atomization area and is electrically connected to the controller.

[0016] Preferably, the bottom of the vibrating screen is attached to three metal wires, with each pair of metal wires intersecting at a junction point. The three junction points form the vertices of an equilateral triangle. One end of each metal wire is connected to the inner wall of the atomizing zone through mounting point one, and the other end of each metal wire is connected to a fixed-angle rotating ring through mounting point two. The fixed-angle rotating ring is fitted onto the outer wall of the atomizing zone.

[0017] Preferably, an annular groove is formed on the outer wall of the atomizing zone, a fixed-angle rotating ring is rotatably installed in the annular groove, a side opening is formed at the bottom of the annular groove to facilitate the passage of the metal wire, a gear ring is installed at the bottom of the fixed-angle rotating ring, a micro motor is installed on the outer wall of the atomizing zone, and a rotating gear that meshes with the gear ring is installed at the output end of the micro motor.

[0018] Preferably, the outer ring of the fixed-angle rotating ring is sealed and connected to the groove end of the annular groove, and the inner ring of the fixed-angle rotating ring is provided with a stepped surface, and the second mounting point is installed on the stepped surface.

[0019] Compared with existing technologies, the advantages of this invention are as follows:

[0020] (1) The present invention provides a novel spray freeze-drying system that, through the integrated design of the granulation unit and the particle collection and drying unit, avoids the boiling and Leiden-Frost effect caused by the direct contact of droplets with the refrigerant in traditional spray freeze-drying, improves the freezing speed and uniformity of particles, reduces the risk of particle agglomeration and clumping, and at the same time preserves the activity of thermally unstable biomolecular drugs and improves the powder yield.

[0021] (2) The present invention provides a novel spray freeze-drying system that applies a vibrating screen spray head to the spray freeze-drying process. Combined with electrostatic assistance and heating feedback control, it achieves low shear force atomization, resulting in spherical particle morphology and good atomization performance. Furthermore, through the optimization of auxiliary diversion pipes, cooling coils and heat exchange coils, it achieves fine control of airflow temperature and continuous process integration, shortens drying time, and supports modular expansion, thereby improving system efficiency and applicability. It is suitable for large-scale pharmaceutical production. Attached Figure Description

[0022] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the granulation unit structure of the present invention;

[0024] Figure 2 This is a schematic diagram of the particle collection and drying unit structure of the present invention;

[0025] Figure 3 This is a schematic diagram of the freezer compartment structure of the present invention;

[0026] Figure 4 This is a schematic diagram of the control principle of the vibrating screen spray head of the present invention;

[0027] Figure 5 This is a schematic diagram of the structure of the vibrating screen spray head of the present invention;

[0028] Figure 6 This is a schematic diagram of the metal wire assembly of the present invention;

[0029] Figure 7 for Figure 6 Enlarged view of number A;

[0030] Figure 8 This is a schematic diagram of the metal wire ice-breaking process of the present invention.

[0031] In the diagram: 1. Refrigeration unit; 10. Freezing chamber; 11. Liquid atomization assembly; 12. Freezing chamber; 13. Refrigeration chamber; 14. Auxiliary diversion pipe; 15. Liquid bottle; 16. Peristaltic pump; 17. Atomizing nozzle; 18. Compressed gas cylinder; 19. Cooling coil; 2. Particle collection and drying unit; 20. Cyclone separator; 22. Inlet; 23. Housing; 24. Heat exchange coil; 25. Liquid chamber area; 26. Atomization area; 27. Outlet area; 28. Vibrating screen; 29. ​​Spray head electrode; 30. Flexible heating element; 31. Thermocouple; 32. Controller; 33. Metal wire; 34. Junction point; 35. Installation point one; 36. Installation point two; 37. Fixed angle rotating ring; 38. Side opening; 39. Micro motor. Detailed Implementation

[0032] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Example:

[0034] The present invention will now be further described with reference to the accompanying drawings.

[0035] like Figures 1 to 3 As shown, this embodiment provides a novel spray freeze-drying system, comprising:

[0036] Granulation unit 1, which includes a freezing chamber 10 and a drug atomization component 11. The drug atomization component 11 atomizes the raw drug solution and sends it into the freezing chamber 10 to freeze it into ice crystals.

[0037] The particle collection and drying unit 2 includes a cyclone separator 20, a blower, and a freeze dryer. The cyclone separator 20 is connected to the freeze chamber 10, and the blower is connected to the cyclone separator 20. The blower draws ice crystals out of the freeze chamber 10 and sends them to the cyclone separator 20. After the cyclone separator 20 collects a certain amount of ice crystals, it is transferred to the freeze dryer for vacuum drying to obtain dry powder.

[0038] The working principle and beneficial effects of the above technical solution are as follows:

[0039] This invention discloses a novel spray freeze-drying system. A drug atomizing component 11 atomizes the raw drug solution into tiny droplets, which are then introduced into a freezing chamber 10 and rapidly frozen into micron-sized ice crystals upon contact with a low-temperature airflow. A blower generates negative pressure to draw the ice crystals through the airflow to a cyclone separator 20 for centrifugal separation and collection. After collecting a preset amount of ice crystals, the system is transferred to a freeze dryer for vacuum drying to remove moisture and obtain dry powder. This novel spray freeze-drying system provides continuous operation from atomization and freezing to collection and drying, avoiding the particle agglomeration and thermal degradation problems of traditional spray freeze-drying. It improves the activity retention rate of biopharmaceuticals while enhancing overall process efficiency.

[0040] In one embodiment, the freezer chamber 10 includes a freezing chamber 12 and a cooling chamber 13. The cooling chamber 13 surrounds the side of the freezing chamber 12 and is connected to the freezing chamber 12 through an auxiliary diversion pipe 14. The cooling chamber 13 is filled with refrigerant. The liquid atomizing assembly 11 is installed at the top of the freezing chamber 12. The inlet end of the cyclone separator 20 extends into the cooling chamber 13 through a quick-release pipe and is connected to the bottom end of the freezing chamber 12.

[0041] The working principle and beneficial effects of the above technical solution are as follows:

[0042] The cooling chamber 13 is filled with refrigerant to generate a cold airflow. A portion of the uncooled air is diverted into the freezing chamber 12 via the auxiliary diversion pipe 14, creating a mixed airflow temperature gradient. The drug atomizing component 11 sprays tiny droplets from the top of the freezing chamber 12. These droplets rapidly freeze into micron-sized ice crystals upon contact with the cold airflow within the freezing chamber 12. The inlet of the cyclone separator 20, via a quick-release pipe, draws airflow carrying the ice crystals from the bottom of the freezing chamber 12 and extends into the cooling chamber 13 to ensure pre-cooling of the airflow and prevent thermal contamination. The entire process achieves indirect cooling and continuous delivery of the droplets. This dual-chamber design enables precise control of the airflow ratio. The auxiliary diversion pipe 14 significantly reduces the occurrence of the Leidenfrost effect and increases the internal freezing speed of the particles, thereby improving protein activity retention and powder yield efficiency. This design is particularly suitable for thermally unstable biopharmaceutical drugs, ensuring system cleanliness and reliability.

[0043] In one embodiment, the liquid atomizing assembly 11 includes a liquid bottle 15, a peristaltic pump 16, and an atomizing nozzle 17 connected in sequence. The atomizing nozzle 17 is installed at the top of the freezing chamber 12, and a compressed gas cylinder 18 is connected to the atomizing nozzle 17 through a valved pipeline.

[0044] The working principle and beneficial effects of the above technical solution are as follows:

[0045] The peristaltic pump 16 draws liquid medication from the drug bottle 15 and delivers it to the atomizing nozzle 17. The compressed gas bottle 18 provides gas through the valve pipeline to assist atomization, forming tiny droplets that are sprayed into the freezing chamber 12. The peristaltic pump 16 ensures precise delivery of the drug medication and avoids contamination. The compressed gas assistance improves atomization efficiency by 10%, making it suitable for heat-labile drugs and reducing the risk of denaturation.

[0046] In one embodiment, the atomizing nozzle 17 is a dual-fluid spray nozzle or a vibrating screen spray nozzle.

[0047] The working principle of the above technical solution is as follows:

[0048] The dual-fluid nozzle utilizes gas-liquid mixing for atomization; the vibrating screen nozzle uses piezoelectric vibration to compress the liquid medicine through micropores, forming droplets.

[0049] In one embodiment, the freezing chamber 12 is cone-shaped, and a cooling coil 19 is spirally wound on the freezing chamber 12. The air inlet end of the cooling coil 19 is connected to the inlet 22 located at the top of the refrigeration chamber 13, and the air outlet end of the cooling coil 19 is close to the bottom end of the freezing chamber 12.

[0050] The working principle and beneficial effects of the above technical solution are as follows:

[0051] The conical freezing chamber 12 guides the droplets to flow downwards from the top, reducing settling losses. The cooling coil 19 introduces cold air from the inlet 22, and the spiral path provides uniform heat exchange around the chamber wall. The cold air circulates in the chamber through convection, and the cold air is released near the bottom of the outlet to assist the ice crystals in being transported to the cyclone separator 20. The conical design combined with the coil forms a stable vortex field, ensuring that the droplets are fully covered and frozen, thereby accelerating the freezing speed and improving the flowability of the particles.

[0052] like Figure 2 As shown, in one embodiment, the particle collection and drying unit 2 further includes:

[0053] The box 23 has several sets of particle collection and drying units 2 arrayed on it. The top of the box 23 has an upper interface, through which the cyclone separator 20 is quickly connected to the blower or freeze dryer. The side of the box 23 has a side interface, through which the cyclone separator 20 is quickly connected to the freezer 10.

[0054] The heat exchange coil 24 is spirally wound on the cyclone separator 20, which can adjust the temperature of the cyclone separator 20 from -50℃ to 50℃.

[0055] The heat exchanger is located inside the housing 23 and is connected to the heat exchange coil 24 via a capillary tube. A dryer filter is installed on the capillary tube.

[0056] The working principle and beneficial effects of the above technical solution are as follows:

[0057] The housing 23 supports the expansion of multiple unit arrays, and the array design supports large-scale production; the heat exchange coil 24 circulates the medium through the heat exchanger and capillary tube to realize the cooling / heating regulation of the cyclone separator 20, and the drying filter removes impurities to ensure the purity of the medium and reduce pollution.

[0058] like Figures 4 to 8 As shown, in one embodiment, the vibrating screen spray head includes a liquid chamber area 25, an atomization area 26, and an outlet area 27 distributed from top to bottom therein. The vibrating screen 28 is located in the atomization area 26 near the liquid chamber area 25. The spray head electrode 29 is installed on the outer wall of the atomization area 26 and is electrically connected to the controller 32. The flexible heating element 30 is wrapped around the outer wall of the outlet area 27 and is electrically connected to the controller 32. Thermocouple 31 is inserted into the atomization area 26 and is electrically connected to the controller 32.

[0059] The working principle and beneficial effects of the above technical solution are as follows:

[0060] The liquid drug enters the atomization zone 26 from the liquid drug chamber 25. Under piezoelectric drive, it is compressed into micron-sized droplets through the micropores (1-5 μm in diameter) of the vibrating screen 28. An electrostatic field is applied by the spray head electrode 29, charging the droplets and further splitting and homogenizing them under Coulomb force. Thermocouple 31 monitors the temperature of the atomization zone 26 in real time and feeds it back to the controller 32 to adjust the flexible heating element 30 to maintain an operating temperature of 20-40°C, ensuring stable droplet ejection in the outlet zone 27 and preventing freezing at low temperatures or denaturation due to overheating. The entire process forms a closed-loop control system, with vibration, electrostatics, and heating working in synergy to achieve low-shear atomization. This integrated design improves atomization efficiency and drug activity retention, reduces droplet aggregation and clogging, thereby ensuring the reliability and cleanliness of the system in spray freeze-drying.

[0061] In one embodiment, the bottom end of the vibrating screen 28 is attached to three metal wires 33. The metal wires 33 are made of NiTi shape memory alloy and have a diameter of 0.2-0.3 mm. Every two metal wires 33 intersect at a junction point 34 with a thickness of 0.4-0.6 mm. The three junction points 34 form the vertices of an equilateral triangle. One end of each metal wire 33 is connected to the inner wall of the atomizing zone 26 through mounting point 1 35, and the other end of each metal wire 33 is connected to a fixed-angle rotating ring 37 through mounting point 2 36. The fixed-angle rotating ring 37 is fitted onto the outer wall of the atomizing zone 26, and the rotation angle of the fixed-angle rotating ring 37 is 10°-30°.

[0062] The working principle and beneficial effects of the above technical solution are as follows:

[0063] Three metal wires 33 are attached to the bottom of the vibrating screen 28 at the vertices of an equilateral triangle. Each pair of metal wires 33 intersects at a junction point 34, ensuring a reduced gap between the metal wires 33 and the screen surface, thus increasing the embedding depth of the metal wires 33 into the ice layer. When the low-temperature cold airflow causes ice to form on the screen surface, the metal wires 33 embed themselves within the ice layer. Thermocouple 31 detects the freezing signal and sends it to controller 32. Controller 32 sends a working command to the fixed-angle rotating ring 37, causing it to rotate and simultaneously pull the three metal wires 33. The displacement of the three metal wires 33 generates shear stress, initiating cracks from within the ice layer. The junction point 34 acts as a force concentration point, moving radially synchronously and causing internal crack propagation, instantly breaking the ice. After breaking the ice, the shape memory effect automatically retracts, returning the wires to their original position. The stepped surface of the rotating ring 37 ensures the stability of mounting point 36, preventing vibration interference. This dynamic ice-breaking mechanism extends the continuous atomization time and is particularly suitable for the low-temperature spray freeze-drying of biological macromolecular drugs, improving the overall system reliability.

[0064] In one embodiment, an annular groove is provided on the outer wall of the atomizing zone 26, and a fixed-angle rotating ring 37 is rotatably installed in the annular groove. A side opening 38 is provided at the bottom end of the annular groove to facilitate the passage of the metal wire 33. A gear ring is installed at the bottom end of the fixed-angle rotating ring 37. A micro motor 39 is installed on the outer wall of the atomizing zone 26, and a rotating gear that meshes with the gear ring is installed at the output end of the micro motor 39.

[0065] The working principle of the above technical solution is as follows:

[0066] The micro motor 39 drives the rotating gear meshing gear ring, rotates the fixed angle rotating ring 37, and adjusts the position of the metal wire 33 through the side opening 38 to achieve ice breaking.

[0067] In one embodiment, the outer ring of the fixed-angle rotating ring 37 is sealed to the groove end of the annular groove, and the inner ring of the fixed-angle rotating ring 37 is provided with a stepped surface, and the mounting point 36 is installed on the stepped surface.

[0068] The working principle of the above technical solution is as follows:

[0069] The outer ring of the fixed-angle rotating ring 37 is sealed to the groove end of the annular groove to prevent leakage. The stepped surface provides mounting point 2 36 for fixing. The sealing connection of the rotating ring 37 ensures airtightness. The metal wire 33 moves synchronously when rotating.

[0070] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A novel spray freeze-drying system, characterized in that, include: The granulation unit (1) includes a freezing chamber (10) and a liquid atomizing component (11). The liquid atomizing component (11) atomizes the raw liquid medicine and sends it into the freezing chamber (10) to freeze it into ice crystals. The particle collection and drying unit (2) includes a cyclone separator (20), a blower and a freeze dryer. The cyclone separator (20) is connected to the freezing chamber (10). The blower is connected to the cyclone separator (20). The blower draws out ice crystals from the freezing chamber (10) and sends them to the cyclone separator (20). After the cyclone separator (20) collects a certain amount of ice crystals, it is transferred to the freeze dryer for vacuum drying to obtain dry powder.

2. The novel spray freeze-drying system according to claim 1, characterized in that, The freezing chamber (10) includes a freezing chamber (12) and a refrigeration chamber (13). The refrigeration chamber (13) surrounds the side of the freezing chamber (12) and is connected to the freezing chamber (12) through an auxiliary diversion pipe (14). The refrigeration chamber (13) is filled with refrigerant. The liquid atomizing component (11) is installed at the top of the freezing chamber (12). The inlet end of the cyclone separator (20) extends into the refrigeration chamber (13) through a quick-release pipe and is connected to the bottom end of the freezing chamber (12).

3. The novel spray freeze-drying system according to claim 2, characterized in that, The liquid atomizing assembly (11) includes a liquid bottle (15), a peristaltic pump (16) and an atomizing nozzle (17) connected in sequence. The atomizing nozzle (17) is installed at the top of the freezing chamber (12), and a compressed gas cylinder (18) is connected to the atomizing nozzle (17) through a valved pipeline.

4. The novel spray freeze-drying system according to claim 3, characterized in that, The atomizing nozzle (17) includes, but is not limited to, a dual-fluid spray nozzle and a vibrating screen spray nozzle.

5. A novel spray freeze-drying system according to claim 2, characterized in that, The freezing chamber (12) is cone-shaped, and a cooling coil (19) is spirally wound on the freezing chamber (12). The air inlet of the cooling coil (19) is connected to the inlet (22) at the top of the refrigeration chamber (13), and the air outlet of the cooling coil (19) is close to the bottom of the freezing chamber (12) to cool the air entering the system.

6. The novel spray freeze-drying system according to claim 1, characterized in that, The particle collection and drying unit (2) further includes: The box (23) has several sets of particle collection and drying units (2) arranged in an array on the box (23). The top of the box (23) has an upper interface. The cyclone separator (20) is quickly connected to the blower or freeze dryer through the upper interface. The side of the box (23) has a side interface. The cyclone separator (20) is quickly connected to the freezer (10) through the side interface. Heat exchange coil (24), which is spirally wound around the cyclone separator (20); The heat exchanger is located inside the housing (23) and is connected to the heat exchange coil (24) via a capillary tube, on which a dryer filter is installed.

7. A novel spray freeze-drying system according to claim 4, characterized in that, The vibrating screen spray head includes a liquid chamber area (25), an atomization area (26) and an outlet area (27) distributed from top to bottom. The vibrating screen (28) is located in the atomization area (26) near the liquid chamber area (25). The spray head electrode (29) is installed on the outer wall of the atomization area (26) and is electrically connected to the controller (32). The flexible heating element (30) is wrapped on the outer wall of the outlet area (27) and is electrically connected to the controller (32). Thermocouple (31) is inserted into the atomization area (26) and is electrically connected to the controller (32).

8. A novel spray freeze-drying system according to claim 7, characterized in that, The bottom end of the vibrating screen (28) is attached to three metal wires (33). Every two metal wires (33) intersect at a junction point (34). The three junction points (34) form the apex of an equilateral triangle. One end of each metal wire (33) is connected to the inner wall of the atomizing zone (26) through mounting point one (35). The other end of each metal wire (33) is connected to a fixed-angle rotating ring (37) through mounting point two (36). The fixed-angle rotating ring (37) is fitted onto the outer wall of the atomizing zone (26).

9. A novel spray freeze-drying system according to claim 8, characterized in that, An annular groove is provided on the outer wall of the atomizing area (26). The fixed-angle rotating ring (37) is rotatably installed in the annular groove. A side opening (38) is provided at the bottom of the annular groove to facilitate the passage of the metal wire (33). A gear ring is installed at the bottom of the fixed-angle rotating ring (37). A micro motor (39) is installed on the outer wall of the atomizing area (26). A rotating gear that meshes with the gear ring is installed at the output end of the micro motor (39).

10. A novel spray freeze-drying system according to claim 9, characterized in that, The outer ring of the fixed-angle rotating ring (37) is sealed to the groove end of the annular groove, and the inner ring of the fixed-angle rotating ring (37) is provided with a stepped surface, and the second mounting point (36) is installed on the stepped surface.

Images