Device and method for measuring pH value of ipratropium bromide solution for inhalation

Abstract

The invention relates to the technical field of pH value measurement, in particular to a device and method for measuring the pH value of an ipratropium bromide solution for inhalation, the device comprises a host unit and a pH electrode probe connected with the host unit through a wire, and an embedded control seat is fixedly arranged in the host unit; the bottom of the solution cup and the embedded control seat are detachably mounted in a butt joint manner; an inert gas compression tank and a main gas valve are arranged in the host unit; a breaking control column is fixedly arranged at the bottom of the embedded control seat; according to the device for measuring the pH value of the ipratropium bromide solution for inhalation, the influence of carbon dioxide in air on the pH value of the ipratropium bromide solution can be greatly reduced under the working condition that the ipratropium bromide solution needs to be measured for a long time such as multiple times of measurement, and the measurement accuracy is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pH value determination, in particular to a pH value determination device and method for an inhaled ipratropium bromide solution. BACKGROUND

[0002] The inhaled ipratropium bromide solution is a commonly used anticholinergic bronchodilator in clinical practice. The chemical structure of the inhaled ipratropium bromide solution is sensitive to pH value. If the pH value is too high or too low, the molecular structure of ipratropium bromide will be destroyed, leading to decomposition of the drug into ineffective components, directly reducing the drug efficacy, and even possibly producing unknown degradation products, increasing the risk of drug use. Therefore, the pH value of the inhaled ipratropium bromide solution often needs to be determined in experimental scenarios. The quaternary ammonium cation of ipratropium bromide itself does not have groups that can undergo protonation or deprotonation, such as amino groups, which are common groups that can participate in acid-base dissociation. The weak alkaline nature of the solution is mainly due to trace impurities such as auxiliary materials or weak base intermediates remaining during the synthesis process, rather than the acid-base dissociation of the drug molecules themselves. The pH buffering capacity of the solution is relatively weak and is easily affected by carbon dioxide in the environment because When dissolved in water, carbonic acid is generated, which is acidic and can cause the pH of the solution to slowly decrease. This results in changes in the measured pH value over time when measuring the pH of the solution. Traditional pH determination devices are used in air environments, and the measurement error is large when measuring the pH of the inhaled ipratropium bromide solution for a long time and multiple times. SUMMARY

[0003] The present application aims to provide a pH value determination device and method for an inhaled ipratropium bromide solution to solve the problem of large measurement error of traditional pH determination devices when measuring for a long time.

[0004] To achieve the above-mentioned purpose, the present application provides the following technical solution: a pH value determination device for an inhaled ipratropium bromide solution, comprising a host unit and a pH electrode probe connected to the host unit through a wire, wherein an embedded control seat is fixedly arranged in the host unit; further comprising a solution cup, the bottom of the solution cup is detachably and dockably installed with the embedded control seat; the host unit is provided with an inert gas compression tank and a main gas valve, and the bottom of the embedded control seat is fixedly provided with a breaking control column, and the inside and outside of the breaking control column are provided with an automatic flow control assembly; the inert gas compression tank is in communication with the bottom of the solution cup through the main gas valve and the automatic flow control assembly in sequence; when the main gas valve is opened, the inert gas in the inert gas compression tank enters the solution cup through the automatic flow control assembly, replacing and discharging the air in the solution cup, and the automatic flow control assembly reduces the flow of inert gas entering the solution cup after the main gas valve is opened for a period of time.

[0005] The automatic flow control assembly comprises a convex pipe part fixedly installed on the breaking control column and a cylindrical inner cavity formed in the breaking control column and the convex pipe part; one end of the cylindrical inner cavity is communicated with an end connecting pipe, the end connecting pipe is communicated with the main gas valve, and when the main gas valve is opened, inert gas enters the cylindrical inner cavity through the end connecting pipe; a driving piston is arranged in the cylindrical inner cavity and can move axially under the pressure of the inert gas.

[0006] A synchronous moving pipe is fixedly arranged on the side of the driving piston facing the position where the end connecting pipe is located, a sealing ring sleeve is fixedly sleeved on the synchronous moving pipe, the outer surface of the sealing ring sleeve is in sliding sealing contact with the inner wall surface of the cylindrical inner cavity, and a gas hole is formed through the synchronous moving pipe.

[0007] A return spring is arranged on the side of the driving piston away from the position where the end connecting pipe is located, the return spring provides supporting elastic force for the driving piston, so that the driving piston has a tendency to move towards the position where the end connecting pipe is located; a limiting top pipe is fixedly arranged at the end of the cylindrical inner cavity, the limiting top pipe axially limits the driving piston, and a flow limiting hole is formed through the end of the cylindrical inner cavity, so that when the driving piston moves towards the limiting top pipe, the gas in the cylindrical inner cavity is discharged to the outside atmosphere through the flow limiting hole.

[0008] The inside of the breaking control column is also provided with an outer ring cavity, the outer ring cavity surrounds the cylindrical inner cavity and is communicated with the bottom of the solution cup; a large-flow gas groove and a small-flow gas hole are formed through the side wall of the cylindrical inner cavity, the large-flow gas groove and the small-flow gas hole both communicate the cylindrical inner cavity with the outer ring cavity, and the through section area of the large-flow gas groove is larger than that of the small-flow gas hole.

[0009] The inside of the main unit is also provided with a gas heating tank, the gas heating tank is communicated with an input pipeline and an output pipeline, and the inside of the embedded control seat is provided with an internal gas path; when the solution cup is docked and installed with the embedded control seat, the internal gas path is communicated with the bottom of the solution cup; the outer ring cavity is communicated with the gas heating tank through the input pipeline, and the gas heating tank is communicated with the internal gas path through the output pipeline; when the inner part of the outer ring cavity is under positive pressure, the gas enters the gas heating tank through the input pipeline, and then enters the solution cup through the output pipeline and the internal gas path in sequence, and the gas heating tank is used for heating the gas passing through the inside thereof.

[0010] A first temperature probe is installed in the input pipeline, and the temperature of the gas flowing through the input pipeline is monitored through the first temperature probe; a second temperature probe is installed in the internal gas path, and the temperature of the gas flowing through the internal gas path is monitored through the second temperature probe.

[0011] The inner wall of the solution cup is provided with a bundle mouth eave near the upper position, and the inner lower surface of the solution cup is provided with a release gas table; a uniform flow cavity is formed in the release gas table, the side wall of the uniform flow cavity is provided with an exhaust micro-hole penetratingly formed outside, the release gas table is provided with a rubber sealing ring outside, the rubber sealing ring is sealed at the end position of the exhaust micro-hole and plays a one-way sealing role, so that the medium in the exhaust micro-hole can push away the rubber sealing ring under pressure and be discharged, and external medium cannot enter the exhaust micro-hole through the rubber sealing ring; a communication vertical channel is formed below the uniform flow cavity, and a butt joint groove is formed below the communication vertical channel.

[0012] The inlaid control seat is provided with a butt joint convex pipe, when the solution cup is butt jointed and installed with the inlaid control seat, the butt joint convex pipe is inserted into the butt joint groove to realize sealed gas supply communication; a one-way valve plug is arranged in the butt joint convex pipe, so that the gas in the butt joint convex pipe flows to the butt joint groove in one direction.

[0013] A method for measuring the pH value of an inhaled ipratropium bromide solution, which adopts an inhaled ipratropium bromide solution pH value measuring device, and comprises the following steps: Step one, pour the inhaled ipratropium bromide solution to be measured into a solution cup; Step two, butt joint the solution cup in the inlaid control seat and open the main gas valve; Step three, insert the pH electrode probe into the solution cup to measure the pH value of the inhaled ipratropium bromide solution in the solution cup.

[0014] Compared with the prior art, the beneficial effects of the present application are: 1. The inhaled ipratropium bromide solution pH value measuring device can greatly reduce the influence of carbon dioxide in the air on the pH value of the ipratropium bromide solution under the working condition of measuring the ipratropium bromide solution for multiple times or for a long time, and improve the accuracy of measurement.

[0015] 2. The automatic flow control assembly can automatically supply high flow rate gas at the beginning after the main gas valve is opened, quickly discharge the air in the solution cup, automatically reduce the gas supply flow rate after the main gas valve is opened for a period of time, maintain the positive pressure of the inert gas in the solution cup, and reduce the loss of the inert gas; and the input inert gas can protect the ipratropium bromide solution, and the structure arrangement of the release gas table and the exhaust micro-hole can make the input inert gas have a stirring effect on the ipratropium bromide solution, improve the uniformity of the ipratropium bromide solution, and make the pH value measurement more accurate.

[0016] 3、The present application is equipped with gas heating tank and other structures, cooperates with automatic flow control assembly and release gas platform, can make the input inert gas at 25 degrees Celsius standard reference temperature, cooperates with the stirring effect of bubble spouting of release gas platform, can make the solution more quickly heat exchange with inert gas, so that the ipratropium bromide solution is more close to 25 degrees Celsius standard reference temperature, reduces the temperature compensation error, improves the determination precision. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is the schematic diagram of the whole structure of the present application.

[0018] Figure 2 It is the cut open schematic diagram of the host unit shell of the present application.

[0019] Figure 3 It is the three-dimensional half cut schematic diagram of the present application.

[0020] Figure 4 It is the three-dimensional half cut local schematic diagram of the control column of the present application.

[0021] Figure 5 It is the three-dimensional half cut front view of the present application.

[0022] Figure 6 It is the three-dimensional half cut local front view of the control column of the present application.

[0023] Figure 7 It is the three-dimensional half cut schematic diagram of the solution cup of the present application.

[0024] Figure 8 It is the three-dimensional half cut schematic diagram of the gas heating tank of the present application.

[0025] In the figure: 1, host unit; 2, pH electrode probe; 3, embedded control seat; 4, solution cup; 5, inert gas compression tank; 6, main gas valve; 7, breaking control column; 701, convex pipe part; 702, cylindrical inner cavity; 703, end connecting pipe; 704, driving piston; 705, synchronous moving pipe; 706, sealing ring sleeve; 707, air hole; 708, return spring; 709, limiting top pipe; 710, flow limiting hole; 711, outer ring cavity; 712, large flow gas groove; 713, small flow air hole; 8, gas heating tank; 801, input pipeline; 802, first temperature probe; 803, output pipeline; 804, internal gas path; 805, second temperature probe; 401, beam eave; 402, release gas table; 403, flow equalizing cavity; 404, exhaust micro hole; 405, rubber sealing ring; 406, communication vertical channel; 407, butt joint groove hole; 301, butt joint convex pipe; 302, one-way valve plug; 806, gas cylinder section; 807, flow monitoring probe; 808, high pressure plug disc; 809, return one-way valve; 810, electric control telescopic module; 101, display unit; 102, control unit; 201, metal stand; 202, probe clamp; 303, seat body internal thread; 408, matching external thread; 601, valve cap; 602, gas tank butt joint; 603, high pressure valve pipe; 811, electric heating wire. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0027] Please refer to Figures 1 to 8 , the present application provides a technical solution: inhaled ipratropium bromide solution pH value measuring device, including host unit 1 and pH electrode probe 2 connected with host unit 1 through wire, pH electrode probe 2 adopts glass electrode, temperature sensor is integrated on pH electrode probe 2, for real-time detection of solution temperature, temperature signal is transmitted to host unit 1, the influence of temperature on pH measurement is automatically corrected, temperature compensation is realized, as shown in Figure 1 , display unit 101 and control unit 102 are arranged on host unit 1, calibration, on-off machine, parameter adjustment and other controls of host unit 1 are carried out through control unit 102, and information display is carried out through display unit 101.

[0028] As Figure 1As shown, a metal column 201 is fixedly inserted into the main unit 1, and a probe clamp 202 is installed on the metal column 201. The probe clamp 202 can be adjusted up and down relative to the metal column 201, and the pH electrode probe 2 is fixedly clamped on the probe clamp 202.

[0029] The main unit 1 is equipped with an embedded control base 3; it also includes a solution cup 4, the bottom of which is detachably connected to the embedded control base 3; such as Figure 4 As shown, an internal thread 303 is provided on the side wall of the embedded control base 3, such as... Figure 7 As shown, a mating external thread 408 is provided at the lower part of the solution cup 4. The solution cup 4 and the embedded control seat 3 are connected by the internal thread 303 and the mating external thread 408.

[0030] The main unit 1 is equipped with an inert gas compression tank 5 and a main gas valve 6. A disconnection control column 7 is fixedly installed at the bottom of the embedded control base 3. Automatic flow control components are installed inside and outside the disconnection control column 7. The inert gas compression tank 5 is connected to the bottom of the solution cup 4 after passing through the main gas valve 6 and the automatic flow control components. When the main gas valve 6 is open, the inert gas in the inert gas compression tank 5 enters the solution cup 4 after passing through the automatic flow control components, replacing and discharging the air in the solution cup 4. The automatic flow control components reduce the flow rate of inert gas entering the solution cup 4 after the main gas valve 6 has been open for a period of time. Figure 3 As shown, a valve cap 601 is provided on the main air valve 6. The valve cap 601 passes through the upper cover plate of the main unit 1. The opening and closing of the main air valve 6 can be controlled by rotating the valve cap 601. A high-pressure valve pipe 603 is connected to the inlet of the main air valve 6. The other end of the high-pressure valve pipe 603 is fixedly connected to a gas tank connector 602. The inert gas compression tank 5 is rotatably sealed to the gas tank connector 602, thereby realizing gas supply.

[0031] like Figure 4 As shown, the automatic flow control assembly includes a protruding tube 701 fixedly mounted on the disconnection control column 7, and a cylindrical inner cavity 702 formed inside the disconnection control column 7 and the protruding tube 701; one end of the cylindrical inner cavity 702 is connected to an end connecting pipe 703, which is connected to the main gas valve 6. When the main gas valve 6 is opened, inert gas enters the cylindrical inner cavity 702 through the end connecting pipe 703; an active piston 704 is provided inside the cylindrical inner cavity 702, which can move axially under the pressure of the inert gas.

[0032] The active piston 704 is welded and fixed on one side facing the position of the end connecting pipe 703, and a synchronous moving pipe 705 is arranged on the side. A sealing ring sleeve 706 is fixedly sleeved on the synchronous moving pipe 705, and the outer surface of the sealing ring sleeve 706 is in sliding sealing contact with the inner wall surface of the cylindrical inner cavity 702. A gas hole 707 is formed through the synchronous moving pipe 705, as shown in Figure 4 The gas hole 707 is arranged in several groups and is uniformly distributed, and the gas hole 707 is used to realize the gas circulation between the inside and outside of the synchronous moving pipe 705.

[0033] The active piston 704 is provided with a return spring 708 on the side away from the position of the end connecting pipe 703. The return spring 708 provides a supporting elastic force for the active piston 704, so that the active piston 704 has a tendency to move towards the position of the end connecting pipe 703. The return spring 708 is used to drive the active piston 704 and other structures to automatically reset.

[0034] A limiting top pipe 709 is welded and fixed at the end of the cylindrical inner cavity 702, and the limiting top pipe 709 axially limits the active piston 704. A limiting hole 710 is formed through the end of the cylindrical inner cavity 702. When the active piston 704 moves towards the limiting top pipe 709, the gas in the cylindrical inner cavity 702 is discharged to the outside atmosphere through the limiting hole 710.

[0035] An outer ring cavity 711 is further formed in the inside of the split control column 7, and the outer ring cavity 711 is arranged around the cylindrical inner cavity 702 and is in communication with the bottom of the solution cup 4 through the outer ring cavity 711. A large-flow gas groove 712 and a small-flow gas hole 713 are formed through the side wall of the cylindrical inner cavity 702. The large-flow gas groove 712 and the small-flow gas hole 713 both make the cylindrical inner cavity 702 communicate with the outer ring cavity 711, and the through section area of the large-flow gas groove 712 is larger than that of the small-flow gas hole 713.

[0036] The inside of the host unit 1 is further provided with a gas heating tank 8, and the gas heating tank 8 is in communication with an input pipe 801 and an output pipe 803. The inside of the embedded control seat 3 is provided with an internal gas path 804, and the internal gas path 804 is in communication with the bottom of the solution cup 4 when the solution cup 4 is docked and installed with the embedded control seat 3. The outer ring cavity 711 is in communication with the gas heating tank 8 through the input pipe 801, and the gas heating tank 8 is in communication with the internal gas path 804 through the output pipe 803. When the inside of the outer ring cavity 711 is under positive pressure, the gas enters the gas heating tank 8 through the input pipe 801, and then enters the solution cup 4 through the output pipe 803 and the internal gas path 804 in sequence. The gas heating tank 8 is used to heat the gas passing through the inside of the gas heating tank 8, as Figure 8As shown, an electric heating wire 811 is installed inside the gas heating tank 8. By energizing the electric heating wire 811, heat is generated, thereby heating the gas passing through the gas heating tank 8.

[0037] A first temperature probe 802 is installed in the input pipe 801 to monitor the temperature of the gas flowing through the input pipe 801; a second temperature probe 805 is installed in the internal gas path 804 to monitor the temperature of the gas flowing through the internal gas path 804.

[0038] A constricted rim 401 is provided on the inner wall of the solution cup 4 near the upper part. The structure of the constricted rim 401 is as follows: Figure 7 As shown, it facilitates the pouring and emptying of the solution and reduces the convection of air with the internal cavity of the solution cup 4. A gas release platform 402 is provided on the lower internal surface of the solution cup 4. The gas release platform 402 has a flow equalization chamber 403. The side wall of the flow equalization chamber 403 has an exhaust micro-hole 404 extending outward. The gas release platform 402 is fitted with a rubber sealing ring 405. The rubber sealing ring 405 seals the end of the exhaust micro-hole 404 and plays a one-way sealing role, so that the medium in the exhaust micro-hole 404 can push open the rubber sealing ring 405 and be discharged under pressure, while the external medium will not enter the exhaust micro-hole 404 through the rubber sealing ring 405. A connecting vertical channel 406 is provided below the flow equalization chamber 403, and a docking slot 407 is provided below the connecting vertical channel 406.

[0039] The embedded control base 3 is provided with a docking protrusion 301. When the solution cup 4 is docked with the embedded control base 3, the docking protrusion 301 will be inserted into the docking slot 407 to achieve sealed gas supply connection. The docking protrusion 301 is provided with a one-way valve plug 302, which allows the gas in the docking protrusion 301 to flow unidirectionally into the docking slot 407.

[0040] like Figure 4 As shown, a cylinder section 806 is provided in the middle of the output pipe 803, and the output pipe 803 is connected to the gas through the cylinder section 806; a flow monitoring probe 807 is installed in the internal gas path 804, and the flow monitoring probe 807 monitors and judges whether there is gas flow in the internal gas path 804; the flow monitoring probe 807 adopts an ultrasonic flow sensor, which measures the gas flow rate by emitting and receiving ultrasonic signals. Since the propagation speed of ultrasonic waves is related to the gas flow rate, the gas flow rate can be accurately measured by calculating the propagation time difference of the sound waves. When the measured propagation time difference of the sound waves is zero or close to zero within the allowable error range, it can be considered that the gas has stopped flowing. The flow monitoring probe 807 is a sensor in the prior art, and will not be described in detail in this application.

[0041] Reference should be made Figure 6 As shown in the cylinder section 806, the strong pressure plug disc 808 is in sliding sealing contact with the inner wall surface of the cylinder section 806, the return check valve 809 is embedded and installed on the strong pressure plug disc 808, and the return check valve 809 allows the gas in the external atmosphere to flow unidirectionally to the inside of the cylinder section 806 through the return check valve 809; one side of the strong pressure plug disc 808 is provided with an electric control telescopic module 810, which is fixedly installed on the inner wall of the main unit 1 by screws, and the strong pressure plug disc 808 is driven to move axially by the electric control telescopic module 810.

[0042] The rubber sealing ring 405 has a certain risk of adhesion when it is in contact with the outer surface of the release gas platform 402 for a long time, which can easily cause the exhaust micro hole 404 to be unable to push away the rubber sealing ring 405 for air injection; in the above structure of the application, when the main gas valve 6 is opened, the flow monitoring probe 807 detects that the gas in the internal gas path 804 does not generate a corresponding strength flow, the electric control telescopic module 810 is controlled to work, so that the electric control telescopic module 810 extends to push the strong pressure plug disc 808 to move axially; as Figure 6 As shown in the strong pressure plug disc 808, the strong pressure plug disc 808 moves axially to the left, and after passing through the side wall air inlet of the cylinder section 806, the internal gas of the cylinder section 806 can be pushed at a very high pressure, forcing the internal pressure of the internal gas path 804 and the flow equalization cavity 403 to increase greatly, so that the exhaust micro hole 404 can separate the rubber sealing ring 405 and push the rubber sealing ring 405 away from the release gas platform 402, the gas pressure is related to the pushing force provided by the electric control telescopic module 810, and the pushing force of the electric control telescopic module 810 is improved through the reduction gear set. When resetting, the strong pressure plug disc 808 moves to the right, and in the initial stage, the return check valve 809 is supplemented to inhale, so that the strong pressure plug disc 808 cannot move to the right.

[0043] A method for measuring the pH value of an inhaled ipratropium bromide solution, which uses an inhaled ipratropium bromide solution pH value measuring device, comprising the following steps: Step one, pour the inhaled ipratropium bromide solution to be measured into the solution cup 4; Step two, dock the solution cup 4 in the embedded control seat 3, and open the main gas valve 6; Step three, insert the pH electrode probe 2 into the solution cup 4 to measure the pH value of the inhaled ipratropium bromide solution in the solution cup 4.

[0044] In use, the ipratropium bromide solution is poured into the solution cup 4, the liquid level submerges the gas release platform 402, and is lower than the level of the beam eaves 401, then the valve cap 601 is manually rotated to open the main gas valve 6, when the main gas valve 6 is opened, the compressed inert gas in the inert gas compression tank 5 is input into the cylindrical inner cavity 702 through the main gas valve 6 and the end connecting pipe 703; as shown in Figure 4 The inside of the cylindrical inner cavity 702 is located in the left area of the driving piston 704, the pressure is raised, the positive pressure inert gas enters the outer ring cavity 711 through the large flow gas groove 712 and the small flow gas hole 713, and pushes the driving piston 704 to overcome the supporting elastic force of the return spring 708, and pushes the driving piston 704 to move to the right.

[0045] At this time, because the large flow gas groove 712 and the small flow gas hole 713 simultaneously input gas into the outer ring cavity 711, the gas flow is large, the inert gas in the outer ring cavity 711 sequentially passes through the input pipeline 801, the gas heating tank 8, the output pipeline 803, the internal gas path 804, the one-way valve plug 302 and the communication vertical channel 406 into the flow equalization cavity 403, and is sprayed out through the exhaust micro-hole 404, so that the inert gas bubbles are sprayed out of the exhaust micro-hole 404, force the air inside the solution cup 4 to be exhausted, and through the bubble rolling floating, the solution inside the solution cup 4 can be stirred, the uniformity of the solution is improved, and the ipratropium bromide solution is protected by exhausting the air containing carbon dioxide inside the solution cup 4, and the pH stability of the ipratropium bromide solution is improved.

[0046] As shown in Figure 4 During the movement of the driving piston 704 to the right, the gas on the right side of the driving piston 704 is discharged to the outside through the flow limiting hole 710, the diameter of the flow limiting hole 710 is proportional to the moving speed of the driving piston 704, when the diameter of the flow limiting hole 710 is smaller, the flow limiting effect is more significant, and the driving piston 704 moves slower, so that time control can be realized, when the driving piston 704 is moved to the right position, the sealing ring sleeve 706 is moved to the right to the position of the large flow gas groove 712, and the large flow gas groove 712 is closed, at this time, the outer ring cavity 711 only inputs gas through the small flow gas hole 713, so that the gas flow from the outer ring cavity 711 to the input pipeline 801 is greatly reduced, and finally the gas flow of the exhaust micro-hole 404 is reduced.

[0047] The above summary is that after the main gas valve 6 is opened, initially, the large flow gas of the exhaust micro-hole 404 generates bubbles, rapidly exhausts the air in the solution cup 4, and stirs the solution inside the solution cup 4 through the bubbles generated by the large flow. After a certain period of time, after the air in the solution cup 4 is exhausted, the small flow gas state is automatically switched, the positive pressure of the inert gas in the solution cup 4 is maintained, and the excessive consumption of the inert gas in the inert gas compression tank 5 is avoided.

[0048] Since the inert gas compression tank 5 is a compressed inert gas tank, when the inert gas compression tank 5 is at room temperature, the inert gas released from the inert gas compression tank 5 will expand and do work on the outside, and the internal energy of the inert gas at the moment of release will decrease, and the temperature will be relatively low. The present application is provided with a structure, so that when the gas passes through the input pipeline 801, it is detected by the first temperature probe 802, and the power supply heating current of the gas heating tank 8 is controlled according to the detection result of the first temperature probe 802, and then rechecked by the second temperature probe 805 to form a closed loop control, so that the gas temperature finally input to the internal gas circuit 804 and rechecked by the second temperature probe 805 is as close as possible to the pH value international standard reference temperature of 25 degrees Celsius.

[0049] Since the pH value is affected by temperature, although the existing pH measuring device usually has a temperature compensation function, that is, according to the temperature influence curve of pH value, combined with the temperature of the measured liquid, the measured pH value is compensated and corrected; but the farther the real temperature of the measured liquid deviates from the pH value international standard reference temperature of 25 degrees Celsius, the greater the compensation error, and still brings certain negative influence. The present application is provided with the above structure, so that the exhaust micro-holes 404 spray inert gas bubbles close to 25 degrees Celsius, and the heat exchange effect is improved by the floating and rolling of the bubbles, so that the temperature of the ipratropium bromide solution approaches 25 degrees Celsius, reduces the error of the temperature compensation function, and further improves the measurement accuracy.

[0050] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A pH measuring device for inhaled ipratropium bromide solution, comprising a main unit and a pH electrode probe connected to the main unit via a wire, characterized in that: An embedded control base is fixedly installed in the host unit; It also includes a solution cup, the bottom of which can be detachably connected to the embedded control base for installation; The main unit is equipped with an inert gas compression tank and a main gas valve. A disconnection control column is fixedly installed at the bottom of the embedded control base. Automatic flow control components are installed inside and outside the disconnection control column. The inert gas compression tank is connected to the bottom of the solution cup after passing through the main gas valve and the automatic flow control components. When the main gas valve is opened, the inert gas in the inert gas compression tank enters the solution cup after passing through the automatic flow control components, replacing and discharging the air in the solution cup. The automatic flow control components reduce the flow rate of inert gas entering the solution cup after the main gas valve has been open for a period of time.

2. The pH measuring device for ipratropium bromide solution for inhalation according to claim 1, characterized in that: The automatic flow control assembly includes a protruding tube fixedly installed on the break control post, and a cylindrical inner cavity opened inside the break control post and the protruding tube. One end of the cylindrical inner cavity is connected to an end connecting pipe, which is connected to the main gas valve. When the main gas valve is opened, inert gas enters the cylindrical inner cavity through the end connecting pipe. An active piston is installed inside the cylindrical cavity, which can move axially under the pressure of an inert gas.

3. The pH measuring device for inhaled ipratropium bromide solution according to claim 2, characterized in that: A synchronous moving tube is fixedly installed on the side of the active piston facing the end connecting pipe. A sealing ring is fixedly fitted on the synchronous moving tube, and the outer surface of the sealing ring is in sliding sealing contact with the inner wall surface of the cylindrical cavity. An air hole is opened through the synchronous moving tube.

4. The pH measuring device for inhaled ipratropium bromide solution according to claim 3, characterized in that: A return spring is provided on the side of the active piston away from the end connecting pipe. The return spring provides a supporting elastic force to the active piston, so that the active piston has a tendency to move in the direction of the end connecting pipe. A limiting tube is fixedly installed at the end of the cylindrical inner cavity. The limiting tube axially limits the active piston. A flow-limiting hole is opened through the end of the cylindrical inner cavity. When the active piston moves toward the limiting tube, the gas in the cylindrical inner cavity is discharged to the outside atmosphere through the flow-limiting hole.

5. The pH measuring device for ipratropium bromide solution for inhalation according to claim 4, characterized in that: The internal structure of the split control column also has an outer ring cavity, which surrounds the inner cavity of the cylinder and is connected to the bottom of the solution cup. A high-flow-rate air groove and a low-flow-rate air hole are formed through the side wall of the cylindrical inner cavity. Both the high-flow-rate air groove and the low-flow-rate air hole enable the cylindrical inner cavity to communicate with the outer annular cavity, and the cross-sectional area of ​​the high-flow-rate air groove is larger than that of the low-flow-rate air hole.

6. The pH measuring device for ipratropium bromide solution for inhalation according to claim 5, characterized in that: The main unit is also equipped with a gas heating tank, which is connected to an input pipe and an output pipe. The embedded control base has an internal gas passage. When the solution cup is installed in conjunction with the embedded control base, the internal gas passage is connected to the bottom of the solution cup. The outer ring cavity is connected to the gas heating tank through an input pipe, and the gas heating tank is connected to the internal gas circuit through an output pipe. When the outer ring cavity is under positive pressure, the gas enters the gas heating tank through the input pipe, and then enters the solution cup through the output pipe and the internal gas path in sequence. The gas heating tank is used to heat the gas passing through it.

7. The pH measuring device for ipratropium bromide solution for inhalation according to claim 6, characterized in that: A first temperature probe is installed in the input pipe to monitor the temperature of the gas flowing through the input pipe. A second temperature probe is installed in the internal gas path to monitor the temperature of the gas flowing through the internal gas path.

8. The pH measuring device for ipratropium bromide solution for inhalation according to claim 1, characterized in that: The solution cup has a constricted rim near the top of its inner wall, and a gas release platform is provided on the lower inner surface of the solution cup. The gas release platform has a flow equalization chamber, and the side wall of the flow equalization chamber has an exhaust micro-hole extending outward. The gas release platform is fitted with a rubber sealing ring, which seals the end of the exhaust micro-hole and plays a one-way sealing role, so that the medium in the exhaust micro-hole can push open the rubber sealing ring and be discharged under pressure, while the external medium will not enter the exhaust micro-hole through the rubber sealing ring. The flow equalization cavity is connected to a connecting vertical channel at its lower part, and a docking slot is connected to the lower part of the connecting vertical channel.

9. The pH measuring device for ipratropium bromide solution for inhalation according to claim 8, characterized in that: The embedded control base is provided with a docking protrusion. When the solution cup is docked with the embedded control base, the docking protrusion will be inserted into the docking slot to achieve a sealed gas supply connection. The docking convex tube is equipped with a one-way valve plug, which allows the gas in the docking convex tube to flow unidirectionally into the docking slot.

10. A method for determining the pH value of an inhalation ipratropium bromide solution, characterized in that, This method uses the pH measuring device for inhaled ipratropium bromide solution as described in any one of claims 1-9, and includes the following steps: Step 1: Pour the ipratropium bromide inhalation solution to be tested into the solution cup; Step 2: Connect the solution cup to the embedded control base and open the main gas valve; Step 3: Insert the pH electrode probe into the solution cup to measure the pH value of the ipratropium bromide solution for inhalation in the solution cup.

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