Tooth whitening oral compositions

Abstract

The present disclosure relates to a tooth whitening oral composition comprising a peroxide, a multivalent phosphate, a divalent metal phosphate, and water.

Description

[0001] Cross-references to related applications

[0002] This application claims priority and benefit to Korean Patent Application No. 10-2024-0100854, filed with the Korean Intellectual Property Office on July 30, 2024, the entire disclosure of which is incorporated herein by reference. Technical Field

[0003] This disclosure relates to a teeth whitening oral composition. Background Technology

[0004] Currently known factors causing tooth discoloration can be divided into intrinsic tooth discoloration caused by damage to the dental nerve, aging, or excessive use of antibiotics such as tetracycline, and extrinsic tooth discoloration caused by food debris deposited on the tooth surface or by nicotine and tar components in cigarettes, coffee, and black tea.

[0005] To prevent teeth that have already become discolored due to these various reasons from continuing to discolor, the technology related to teeth whitening oral compositions has long been known to the public. Currently, most commercially available teeth whitening toothpastes contain peroxides that release reactive oxygen species, such as hydrogen peroxide.

[0006] It is well known that the aforementioned peroxides have teeth whitening effects; however, due to the reactivity between commonly used toothpaste ingredients, especially water, abrasives, and peroxides, formulating peroxides into toothpaste products is not straightforward. Furthermore, this reactivity also presents limitations due to decreased storage stability.

[0007] Furthermore, although peroxides are stable at low pH levels, their oxidative effect is more significant than their whitening effect. Conversely, at high pH levels, their whitening effect is known to be more significant than their oxidative effect, but peroxides rapidly decompose into water and hydrogen gas, making long-term storage difficult. Therefore, under long-term storage conditions, toothpaste containers may swell or crack, potentially leaking out and leaving insufficient peroxides to effectively clean and whiten teeth. Additionally, the pH level decreases with long-term storage, which may adversely affect enamel erosion. Enamel erosion is generally considered to occur at pH 5 or lower.

[0008] Therefore, in the prior art, for oral compositions containing peroxides, the initial content of peroxides and pH largely depend on the storage period. If stored before sale or by the user, the peroxides may decompose to an unacceptable degree, thereby losing their whitening effect and becoming limited due to the decrease in pH.

[0009] Accordingly, in general, in order to secure stability of hydrogen peroxide, a tooth whitening composition has been developed to have a pH level of 4 to 5, or has been developed to have a pH of 5 or more and a formulation that is almost free of moisture. This is because when the pH is 5 or more and contains an excess of moisture, decomposition of peroxide can be promoted, which results in loss of whitening efficacy in the case of long-term storage. Accordingly, conventionally, efforts have been made to improve stability of peroxide by reducing or eliminating water content at a pH of 5 or more. However, in this case, there arise some limitations such as an increase in manufacturing cost, a decrease in use feeling. Accordingly, there is an urgent need for a tooth whitening composition that contains an excess of moisture, thereby exhibiting excellent performance in terms of cost competitiveness and use feeling, while securing stability of hydrogen peroxide at a pH of 5.5 or more, thereby reducing tooth erosion.

[0010] Prior Art Documents

[0011] Patent Documents

[0012] Korean Patent Registration No. 10-0149395 SUMMARY

[0013] The present disclosure provides a tooth whitening oral composition that stabilizes peroxide at a high pH while increasing the content of water, thereby improving use feeling and reducing manufacturing cost.

[0014] The objectives to be achieved by the present disclosure are not limited to the above-mentioned objectives, and other objectives not mentioned will be clearly understood by those skilled in the art from the following description.

[0015] To achieve the above-mentioned objectives, the embodiments of the present disclosure provide a tooth whitening oral composition including peroxide, polyvalent phosphate, divalent metal phosphate, and water, and the pH can be 5.5 or more.

[0016] The peroxide can be one or more selected from the group consisting of substances capable of releasing hydrogen peroxide, which can include hydrogen peroxide, urea peroxide, calcium peroxide, sodium percarbonate, and sodium perborate.

[0017] The polyvalent phosphate can be one or more selected from the group consisting of polyvalent phosphates having a linear form, a cyclic form, or a branched form, which can include sodium metaphosphate, sodium pyrophosphate, sodium polyphosphate, potassium pyrophosphate, acid sodium pyrophosphate, acid sodium poly-metaphosphate, and acid sodium polyphosphate.

[0018] The divalent metal phosphate can be one or more selected from the group consisting of calcium, magnesium, copper, and phosphates thereof.

[0019] The content of the peroxide can be 0.01 to 10 wt%, the content of the polyvalent phosphate can be 0.01 to 5 wt%, the content of the divalent metal phosphate can be 0.01 to 2 wt%, and the content of the water can be 5 to 55 wt%, based on the total amount of the tooth whitening oral composition.

[0020] The tooth whitening oral composition can further include one or more selected from the group consisting of a binding agent and a solubilizing agent.

[0021] The binding agent can include one or more selected from the group consisting of a substance capable of forming a hydrogen bond with hydrogen peroxide, which can include polyvinylpyrrolidone, polyacrylamide, polyvinylpyrrolidone-vinyl acetate copolymer, and poly(2-ethyl-2-oxazoline).

[0022] The solubilizing agent is a surfactant having an HLB of 14 to 23, which can be one or more selected from the group consisting of poloxamer 407, poloxamer 184, sorbitan polyoxyethylene (20) ether stearate, sorbitan polyoxyethylene (20) ether oleate, sorbitan polyoxyethylene (20) ether laurate, polyoxyethylene hydrogenated castor oil-40 (HCO40), and polyoxyethylene hydrogenated castor oil-60 (HCO60).

[0023] The tooth whitening oral composition can further include one or more additives selected from the group consisting of an abrasive, a viscosity adjusting agent, a pH adjusting agent, a wetting agent, a foaming agent, a sweetening agent, and a flavoring agent.

[0024] The tooth whitening oral composition according to the present disclosure improves the stability of hydrogen peroxide at a high pH, prevents a decrease in pH and hydrogen peroxide even during long-term storage, and maintains a tooth whitening effect while maintaining a pH higher than a tooth erosion pH, thereby being capable of preventing tooth damage due to pH. In addition, since a high water content can be maintained, an excellent use feeling can be achieved, and economic advantages in terms of cost can be achieved.

[0025] Effects of the present disclosure are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those skilled in the art from the following description. BRIEF DESCRIPTION OF DRAWINGS

[0026] The accompanying drawings are intended to aid in further understanding of the present disclosure, and are incorporated in and constitute a part of the specification. The drawings illustrate exemplary embodiments of the present disclosure and, together with the specification, serve to explain principles of the present disclosure. In the drawings:

[0027] Figure 1 is a photograph of a test sample for evaluating a whitening effect, and

[0028] Figure 2 This is a graph showing the color difference measurement results in the evaluation of whitening effect. Detailed Implementation

[0029] The advantages and features of this disclosure, as well as methods of implementing them, will become apparent from the exemplary embodiments described in detail below. However, this disclosure is not limited to the embodiments disclosed below, but may be embodied in various different forms. Rather, these exemplary embodiments are provided to make this disclosure more thorough and complete, and to fully communicate the scope of this disclosure to those skilled in the art to which it pertains; therefore, this disclosure is limited only by the scope of the claims.

[0030] The terminology used in this specification is for describing embodiments and is not intended to limit this disclosure. In this specification, the singular form includes the plural form as well as the singular form, unless otherwise specified herein. The terms “comprising” and / or “including” as used in the specification do not exclude the presence or addition of one or more other components besides the mentioned components. Throughout the specification, “and / or” includes each and all combinations of one or more of the mentioned components. Although “first,” “second,” etc., are used to describe various components, it is not in doubt that these components are not limited by these terms. These terms are used only to distinguish one component from another. Therefore, it is not in doubt that a first component described below can be a second component within the technical concept of this disclosure.

[0031] Unless otherwise defined, all terms used in this specification (including technical and scientific terms) are to be understood in the same sense as commonly understood by one of ordinary skill in the art to which this disclosure pertains. Furthermore, terms defined in common dictionaries should not be idealized or over-interpreted unless they have a clear and specific definition.

[0032] This disclosure will now be described in detail.

[0033] This disclosure provides a teeth whitening oral composition comprising peroxide, polyphosphate, divalent metal phosphate and water.

[0034] In one exemplary embodiment, the pH of the teeth whitening oral composition can be 5.5 or higher, 5.5 to 8.5, 5.5 to 7.1, or 5.5 to 6.8. When the teeth whitening oral composition has a high pH within the above range, the teeth whitening effect is excellent.

[0035] In one exemplary embodiment, the peroxide may be one or more substances selected from the group consisting of substances capable of releasing hydrogen peroxide. Examples of substances capable of releasing hydrogen peroxide include hydrogen peroxide, urea peroxide, calcium peroxide, sodium percarbonate, and sodium perborate. As a specific example, the peroxide may be hydrogen peroxide.

[0036] As is well known, peroxides are components that release reactive oxygen species and are effective in whitening teeth. However, peroxides have limitations due to their poor compatibility with commonly used toothpaste ingredients and their high reactivity leading to decreased storage stability. Furthermore, while peroxides are stable at low pH levels, their oxidizing effect outweighs their whitening effect. Conversely, at high pH levels, their whitening effect is known to outweigh their oxidizing effect, but peroxides rapidly decompose into water and hydrogen gas, making long-term storage difficult. Therefore, under long-term storage conditions, toothpaste containers may swell or crack, potentially leaking out and leaving insufficient peroxides for effective cleaning and whitening. Additionally, long-term storage lowers the pH, which can adversely affect enamel erosion. Thus, in existing technologies, for oral compositions containing peroxides, the initial peroxide content and pH largely depend on the shelf life. Storage before sale or by the user can lead to unacceptable decomposition of peroxides, resulting in loss of whitening efficacy and limitations due to pH decline. In addition, existing technologies attempt to improve the stability of peroxides at high pH by reducing or eliminating the water content. However, this approach has limitations such as increased manufacturing costs and reduced user experience.

[0037] Therefore, the purpose of this disclosure is to provide a teeth whitening oral composition that can improve the stability of hydrogen peroxide at high pH, ​​prevent the decrease of pH and hydrogen peroxide even during long-term storage, reduce manufacturing costs, and achieve excellent user experience.

[0038] In one exemplary embodiment, the peroxide content can be 0.01 wt% to 10 wt%, 0.1 wt% to 7 wt%, 0.5 wt% to 5 wt%, 0.5 wt% to 3 wt%, or 0.5 wt% to 1.5 wt%, depending on the total amount of the teeth whitening oral composition. A whitening effect can be achieved when the peroxide content is within the above ranges.

[0039] In one exemplary embodiment, the polyphosphate may be one or more selected from the group consisting of polyphosphates having a linear, cyclic, or branched form. Examples of polyphosphates having a linear, cyclic, or branched form include sodium metaphosphate, sodium pyrophosphate, sodium polyphosphate, potassium pyrophosphate, acidic sodium pyrophosphate, acidic sodium polymetaphosphate, and acidic sodium polyphosphate. As a specific example, the polyphosphate may be sodium metaphosphate.

[0040] Based on the total amount of the teeth whitening oral composition, the content of polyvalent phosphate can be from 0.01 wt% to 5 wt%, 0.01 wt% to 3 wt%, 0.3 wt% to 3 wt%, or 0.3 wt% to 1.5 wt%. By keeping the content of polyvalent phosphate within the above ranges, peroxide stability and pH stability can be improved.

[0041] In one exemplary embodiment, the divalent metal phosphate may be one or more selected from the group consisting of calcium, magnesium, copper, and their phosphates. For example, the divalent metal phosphate may be one or more selected from the group consisting of hydroxyapatite, calcium phosphate, tricalcium phosphate, calcium dihydrogen phosphate, calcium diphosphate, calcium pyrophosphate, acid calcium pyrophosphate, trimagnesium phosphate, dimagnesium phosphate, monomagnesium phosphate, and copper pyrophosphate. As a specific example, the divalent metal phosphate may be a calcium-containing phosphate, which is one or more selected from the group consisting of hydroxyapatite, calcium phosphate, tricalcium phosphate, and calcium pyrophosphate.

[0042] Based on the total amount of the teeth whitening oral composition, the content of divalent metal phosphates can be 0.01wt% to 2wt%, 0.01wt% to 1wt%, 0.01wt% to 0.8wt%, 0.05wt% to 0.5wt%, 0.075wt% to 0.5wt%, or 0.075wt% to 0.3wt%. If the content of divalent metal phosphates is within the above ranges, the stability of hydrogen peroxide and pH stability can be improved.

[0043] In one exemplary embodiment, the water may be included, such as purified water. Based on the total amount of the teeth whitening oral composition, the water content may be 5 wt% to 55 wt%, 10 wt% to 52 wt%, 35 wt% to 52 wt%, or 35 wt% to 45 wt%. When the water content is within the above ranges, the stability of the peroxide can be improved.

[0044] In one exemplary embodiment, the teeth whitening oral composition may further comprise an adhesive. As the adhesive, one or more polymeric adhesives selected from the group consisting of substances capable of forming hydrogen bonds with hydrogen peroxide can be used. Examples of polymeric adhesives include polyvinylpyrrolidone, polyacrylamide, polyvinylpyrrolidone-vinyl acetate copolymer, and poly(2-ethyl-2-oxazoline). The adhesive functions to capture peroxides and improve their stability.

[0045] As a specific example, the adhesive may include polyvinylpyrrolidone (PVP). As PVP, PVP in linear or cross-linked forms can be used without limitation. PVP is a polymer with minimal influence on the reaction between coprecipitates and peroxides, effectively promoting the decomposition of organic matter, and does not interfere with the release and migration of free radicals to the teeth when using tooth-whitening oral compositions containing peroxides.

[0046] In one exemplary embodiment, the binder content can be 0.01 wt% to 10 wt%, 0.1 wt% to 7 wt%, 0.5 wt% to 5 wt%, or 0.5 wt% to 3 wt%, depending on the total amount of the teeth whitening oral composition. When the binder content is within the above ranges, the stability of the peroxide in the formulation can be improved.

[0047] In one exemplary embodiment, the weight ratio of the adhesive to the peroxide can be greater than 0.27, 0.35 or more, 0.53 or more, 0.53 to 5, or 0.53 to 3. Adjusting the weight ratio of the adhesive to the peroxide to these ranges can improve the stability of the peroxide.

[0048] In one exemplary embodiment, the teeth whitening oral composition may further comprise a solubilizer. The solubilizer may, for example, be a surfactant comprising HLB14 to HLB23.

[0049] Surfactants with an HLB of 14–23 can be, for example, selected from one or more of the group consisting of poloxamer 407, poloxamer 184, sorbitan polyoxyethylene (20) ether stearate, sorbitan polyoxyethylene (20) ether oleate, sorbitan polyoxyethylene (20) ether laurate, polyoxyethylene hydrogenated castor oil-40 (HCO40), and polyoxyethylene hydrogenated castor oil-60 (HCO60). As a specific example, the surfactant can be a poloxamer-based surfactant. The role of the surfactant is to capture peroxides with a binder and further capture them in the formulation, thereby improving the stability of the peroxides.

[0050] Based on the total amount of the teeth whitening oral composition, the surfactant content can be from 0.01 wt% to 5 wt%, 0.01 wt% to 3 wt%, and 1 wt% to 2 wt%. When the solubilizer content is within the above ranges, the stability of the peroxide can be improved.

[0051] In one exemplary embodiment, the teeth-whitening oral composition may further comprise one or more additives selected from the group consisting of abrasives, viscosity modifiers, pH adjusters, humectants, foaming agents, sweeteners, and flavoring agents. Abrasives, viscosity modifiers, pH adjusters, humectants, foaming agents, sweeteners, and flavoring agents are not particularly limited, as long as they are present in a typical oral composition. Furthermore, other additives that are present in a typical oral composition may also be included.

[0052] The abrasive may include one or more of, for example, selected from the group consisting of colloidal silica, stearic acid anhydride, silica, aluminum hydroxide, and insoluble sodium metaphosphate. There is no particular limitation on the content of the abrasive; however, based on the total amount of the teeth-whitening oral composition, its content may be, for example, 1 wt% to 15 wt%, 1 wt% to 10 wt%, 3 wt% to 10 wt%, or 6 wt% to 8 wt%.

[0053] The viscosity modifier may be one or more selected from the group consisting of polyvinyl alcohol, polyoxyethylene polyoxypropylene glycol, alginate, hydroxypropyl methylcellulose, hydroxyethyl cellulose, methylcellulose, carboxymethyl cellulose, xanthan gum, acrylate copolymers, and polyvinylpyrrolidone-vinyl acetate copolymers. There is no particular limitation on the content of the viscosity modifier; however, based on the total amount of the teeth whitening oral composition, its content may be, for example, 0.1 wt% to 5 wt%, 0.1 wt% to 3 wt%, or 0.5 wt% to 1.5 wt%.

[0054] The pH adjuster may be one or more selected from the group consisting of phosphoric acid, citric acid, and their salts. For example, the pH adjuster may be one or more selected from the group consisting of phosphoric acid, sodium diphosphate, sodium monophosphate, sodium polyphosphate, sodium pyrophosphate, acidic sodium pyrophosphate, sodium triphosphate, citric acid, and sodium citrate. There is no particular limitation on the content of the pH adjuster; however, based on the total amount of the teeth whitening oral composition, its content may be, for example, 0.01 wt% to 1 wt%, 0.05 wt% to 1 wt%, 0.05 wt% to 0.5 wt%, or 0.05 wt% to 0.3 wt%.

[0055] The wetting agent may include one or more of, for example, selected from the group consisting of polyethylene glycol, sorbitol, glycerin, dipropylene glycol, and propylene glycol. There is no particular limitation on the content of the wetting agent; however, based on the total amount of the teeth-whitening oral composition, its content may be, for example, 10 wt% to 70 wt%, 10 wt% to 55 wt%, 30 wt% to 60 wt%, or 37 wt% to 50 wt%.

[0056] The wetting agent may comprise: a first wetting agent comprising sorbitol; and a second wetting agent comprising glycerol; the first wetting agent and the second wetting agent may be contained in a weight ratio of 1:1.5 to 1:5, 1:2 to 1:4, or 1:2 to 1:3. When the first wetting agent and the second wetting agent are mixed in a weight ratio within the above range, the stability and appearance stability of hydrogen peroxide can be improved while maintaining the pH of the composition at 5.5 or above.

[0057] The foaming agent may include one or more selected from the group consisting of anionic surfactants such as sodium lauryl sulfate and betaine. There is no particular limitation on the content of the foaming agent; however, based on the total amount of the teeth-whitening oral composition, its content may be, for example, 0.1 wt% to 10 wt%, 0.1 wt% to 7 wt%, 0.1 wt% to 5 wt%, or 0.5 wt% to 3 wt%.

[0058] Sweeteners may include one or more selected from the group consisting of saccharin, sodium saccharin, enzymatically processed stevia, sucralose, acesulfame potassium, aspartame, and xylitol. There is no particular limitation on the content of the sweetener, which may be, for example, 0.01 wt% to 5 wt%, 0.1 wt% to 3 wt%, or 0.01 wt% to 1 wt% based on the total amount of the teeth-whitening oral composition.

[0059] There are no particular restrictions on the type and amount of flavoring agent; however, based on the total amount of the teeth whitening oral composition, its content may be, for example, 0.01 wt% to 5 wt%, 0.1 wt% to 3 wt%, or 0.5 wt% to 1.5 wt%.

[0060] There is no particular limitation on the total content of sweeteners and flavorings; however, based on the total amount of the teeth whitening oral composition, the total content can be from 0.1 wt% to 10 wt%.

[0061] Specific embodiments of this disclosure are given below. However, the following embodiments are only for illustrative purposes or to describe this disclosure in detail, and therefore this disclosure should not be limited thereto. In addition, for matters not described herein, those skilled in the art can fully infer them from the technical details, and therefore their description is omitted.

[0062] [Preparation of Examples and Comparative Examples]

[0063] Examples 1 to 10 and Comparative Examples 1 to 3

[0064] The amounts of calcium phosphate, sodium hexametaphosphate, hydrogen peroxide (H2O2), and purified water were adjusted relative to the total amount (100 wt%) of the oral composition as shown in Table 1 below. In each example and comparative example, binders, solubilizers, pH adjusters, abrasives, wetting agents, viscosity modifiers, foaming agents, sweeteners, and flavoring agents were also mixed to prepare the teeth whitening oral composition (unit: wt% relative to the total weight of the composition).

[0065] pH should be measured according to the following standards.

[0066] [Evaluation Criteria] – pH

[0067] Measurement method: pH was measured using a diluent (10% of each test group + 90% of purified water).

[0068] Target: 5.5 or higher

[0069] [Table 1]

[0070]

[0071] [Experimental Example]

[0072] Experimental Example 1: Evaluation of the stability and appearance stability of hydrogen peroxide

[0073] For the compositions of the examples and comparative examples prepared above, the hydrogen peroxide stability and appearance stability were evaluated according to the following method.

[0074] [Evaluation Criteria] - Hydrogen Peroxide Stability

[0075] Measurement method: The hydrogen peroxide content was measured by potentiometric titration under accelerated storage conditions that yielded results similar to those obtained after 3 years of storage at room temperature.

[0076] X: Reduction in hydrogen peroxide: greater than 15%

[0077] ○: Reduction of hydrogen peroxide: 15% or less

[0078] Target: equal to or higher than ○

[0079] [Evaluation Criteria] - Appearance Stability

[0080] Verification method: After storing the tube containing an appropriate amount of test group under high temperature conditions for a certain period of time, evaluate the degree of air bubbles in the tube.

[0081] ×: The tube is severely swollen, and a large number of air bubbles can be observed with the naked eye.

[0082] ○: The tube expansion is not serious, and no large air bubbles were observed with the naked eye.

[0083] Target: equal to or higher than ○

[0084] The evaluation results are shown in Table 2 below.

[0085] [Table 2]

[0086]

[0087] Referring to Table 2, it can be confirmed that when a teeth whitening oral composition is formed according to the compositions of this disclosure, excellent hydrogen peroxide stability and appearance stability are achieved at a pH of 5.5 or higher. In the case of Example 10, it can be confirmed that a composition with low hydrogen peroxide stability and appearance stability is formed due to the high content of purified water.

[0088] On the other hand, in Comparative Example 1, it was confirmed that the composition with low appearance stability was formed due to the absence of polyvalent phosphates; in Comparative Example 2, it was confirmed that the composition with low hydrogen peroxide stability was formed due to the absence of divalent metal phosphates. In Comparative Example 3, although neither polyvalent nor divalent metal phosphates were present, the composition formed had good stability due to its low pH, but the pH was below 5.5.

[0089] Experimental Example 2: Evaluation of the stability of hydrogen peroxide depending on the weight ratio of polyvinylpyrrolidone / hydrogen peroxide

[0090] A teeth whitening oral composition was prepared according to Example 1, and the weight ratio of polyvinylpyrrolidone (PVP) to hydrogen peroxide (H2O2) was adjusted to 0.27 to 2.66. The reduction of hydrogen peroxide under high temperature conditions was evaluated according to the following criteria, and the results are shown in Table 3.

[0091] Evaluation Criteria

[0092] X: Greater than 15%

[0093] △: Greater than 10% and less than or equal to 15%

[0094] ○: 10% or less

[0095] (Target: equal to or higher than △)

[0096] [Table 3]

[0097]

[0098] Referring to Table 3, it can be confirmed that when the weight ratio of polyvinylpyrrolidone / hydrogen peroxide is 0.27, the amount of hydrogen peroxide reduced increases and the stability of hydrogen peroxide deteriorates. It can also be confirmed that when the weight ratio is greater than 0.27, the evaluation result of hydrogen peroxide is equal to or higher than Δ, which meets the target physical properties.

[0099] Experimental Example 3: Evaluation of the whitening efficacy of a teeth whitening oral composition (in vitro)

[0100] The whitening efficacy of the tooth whitening oral compositions of Examples 1 and 2 and the toothpaste of Reference Example 1 was evaluated.

[0101] Reference Example 1 is an existing commercially available whitening toothpaste with a pH of 3.5 to 5.5, a hydrogen peroxide content of 0.75 wt% of the total weight of the whitening toothpaste, and a water content of 32 to 45 wt% of the total weight of the whitening toothpaste. The resulting whitening toothpaste is a product that does not contain calcium phosphate or sodium metaphosphate. Specifically, HAP discs made from appropriately sized tablets using hydroxyapatite (HAP) powder are purchased and prepared. The HAP discs are treated in a dilute hydrochloric acid solution, then thoroughly cleaned, and then immersed in a coffee solution to artificially contaminate the HAP discs, resulting in coffee-stained HAP discs as samples. A dilute hydrochloric acid solution is used to promote coffee staining. The prepared HAP discs and coffee-stained HAP discs can be obtained below. Figure 1 This has been confirmed.

[0102] The initial L value (L = luminance, L = 100 is defined as pure white, L = 0 is defined as black) of the coffee-stained HAP plate samples was measured using a colorimeter. The tooth-whitening oral compositions prepared in the above examples and comparative examples were diluted with water and applied to the samples, then left to stand at room temperature for 60 minutes. The samples were then cleaned and dried after removing the tooth-whitening oral composition, and the L value was measured again. The difference in L value before and after treatment with the tooth-whitening oral composition, ΔL, was calculated. For each sample, the color difference was measured five times before and after treatment, and the average value was calculated. The results are shown in Table 4 below. Figure 2 As shown.

[0103] [Table 4]

[0104]

[0105] Refer to Table 4 and Figure 2 It can be confirmed that the teeth whitening oral composition according to this disclosure has excellent whitening effect.

[0106] Experimental Example 4: Safety Evaluation of Oral Hard Tissues (In Vitro)

[0107] The oral cavity safety of the teeth whitening oral composition of Example 1 and the toothpaste of Reference Example 1 was evaluated.

[0108] For the in vitro evaluation of oral hard tissue safety, the Chinese Hard Tissue Safety Evaluation Standard (GB / T40002) was followed. The treatment time for the test group was extended from 5 minutes to 30 minutes, and bovine tooth samples were used for the in vitro evaluation. Specifically, to conduct the above evaluation, two bovine tooth samples were treated as follows: first with a sample diluent for 30 minutes, then with artificial saliva for 30 minutes, for a total of 6 cycles. The initial microhardness of each sample was measured 4 times, and its average value was calculated. After 6 cycles, the microhardness was measured 4 more times, and its average value was calculated. The differences are shown in Table 5 below. Here, a Vickers hardness tester was used to measure the microhardness.

[0109] [Table 5]

[0110]

[0111] Referring to Table 5, it can be confirmed that although the processing time has been extended to 30 minutes in the existing hard tissue safety evaluation criteria, the tooth whitening oral composition according to this disclosure showed almost no decrease in hardness after six cycles.

[0112] Although exemplary embodiments of this disclosure have been described, those skilled in the art to which this disclosure pertains will understand that this disclosure can be implemented in other specific forms without altering the technical concept or essential features. Therefore, it should be understood that the above embodiments should be construed as exemplary and not as limiting.

Claims

1. A tooth whitening oral composition comprising: a peroxide; a polyvalent phosphate; a divalent metal phosphate; and water; wherein the tooth whitening oral composition has a pH of 5.5 or more. 2.The tooth whitening oral composition according to claim 1, wherein the peroxide is one or more selected from the group consisting of substances capable of releasing hydrogen peroxide, and the substance capable of releasing hydrogen peroxide includes hydrogen peroxide, urea peroxide, calcium peroxide, sodium percarbonate, and sodium perborate. 3.The tooth whitening oral composition according to claim 1, wherein, the polyvalent phosphate is one or more selected from the group consisting of polyvalent phosphates having a linear form, a cyclic form, or a branched form, and the polyvalent phosphate having a linear form, a cyclic form, or a branched form includes sodium metaphosphate, sodium pyrophosphate, sodium polyphosphate, potassium pyrophosphate, acid sodium pyrophosphate, acid sodium poly-metaphosphate, and acid sodium polyphosphate. 4.The tooth whitening oral composition according to claim 1, wherein the divalent metal phosphate is one or more selected from the group consisting of calcium, magnesium, copper, and phosphates thereof. 5.The tooth whitening oral composition according to claim 1, wherein the content of the peroxide is 0.01 wt% to 10 wt% based on the total amount of the tooth whitening oral composition, the content of the polyvalent phosphate is 0.01 wt% to 5 wt%, the content of the divalent metal phosphate is 0.01 wt% to 2 wt%, and the content of the water is 5 wt% to 55 wt%. 6.The tooth whitening oral composition according to claim 1, further comprising: one or more selected from the group consisting of a binding agent and a solubilizing agent. 7.The tooth whitening oral composition according to claim 6, wherein, the binding agent is one or more selected from the group consisting of substances capable of forming a hydrogen bond with hydrogen peroxide, and the substance capable of forming a hydrogen bond with hydrogen peroxide includes polyvinylpyrrolidone, polyacrylamide, polyvinylpyrrolidone-vinyl acetate copolymer, and poly(2-ethyl-2-oxazoline). 8.The tooth whitening oral composition according to claim 6, wherein, the weight ratio of the binding agent to the peroxide is greater than 0.

27. 9.The tooth whitening oral composition according to claim 6, wherein the solubilizing agent is a surfactant having an HLB of 14 to 23, and the surfactant having an HLB of 14 to 23 is one or more selected from the group consisting of poloxamer 407, poloxamer 184, sorbitan polyoxyethylene (20) stearate, sorbitan polyoxyethylene (20) oleate, sorbitan polyoxyethylene (20) laurate, polyoxyethylene hydrogenated castor oil-40 (HCO40), and polyoxyethylene hydrogenated castor oil-60 (HCO60). 10.The tooth whitening oral composition according to claim 1, further comprising: one or more additives selected from the group consisting of an abrasive, a viscosity adjusting agent, a pH adjusting agent, a wetting agent, a foaming agent, a sweetening agent, and a flavoring agent.

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