External application ointment for mud moxibustion and preparation method thereof

Abstract

The invention discloses an external application ointment for mud moxibustion and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The external application ointment for mud moxibustion is prepared from the following components in parts by weight: 15-30 parts of traditional Chinese medicine extract, 40-60 parts of mineral mud, 5-15 parts of beewax, 2-8 parts of penetration enhancer, 1-5 parts of stabilizer and 1-3 parts of dipotassium glycyrrhizinate, wherein the traditional Chinese medicine extract is prepared by the following steps: weighing sarcandra glabra or kadsura coccinea, giantleaf ardisia rhizome, kadsura coccinea, folium artemisiae argyi and garden balsam stem according to the weight ratio of (6-10): (4-8): (3-7): (1-6): (1-5), crushing, adding water for soaking, decocting, filtering, and concentrating the filtrate into extract with the relative density of 1.1-1.2 at 60 DEG C, thereby obtaining the traditional Chinese medicine extract. The formula of the traditional Chinese medicine extract in the ointment is elaborately developed from clinical proved prescriptions, the formula is simple, and the ointment has remarkable effects of activating blood, dispelling wind, eliminating dampness and relieving pain on symptoms such as pain caused by various reasons.

Description

Technical Field

[0001] This invention relates to a topical ointment for mud moxibustion and its preparation method, belonging to the field of traditional Chinese medicine technology. Background Technology

[0002] Mud moxibustion is a treatment method that uses hot mud to stimulate specific parts of the body to treat and prevent diseases. It is an extension of the ancient wax moxibustion therapy. Based on the principles of meridian theory and modern medicine, and in accordance with molecular medicine theory, biomedical holographic theory, and the traditional Chinese medicine theories of treating internal diseases externally and treating different diseases with the same method, it safely and effectively removes wind, cold, dampness, heat, and toxins from the body by stimulating acupoints, unblocking meridians, and conducting medicinal heat. This achieves the effects of treating diseases, preventing diseases, strengthening the body's foundation, promoting metabolism, and enhancing the body's immunity.

[0003] Mud moxibustion has strong flexibility and can be applied to any part of the body. It has good curative effect and fast results. It has multiple effects such as promoting blood circulation, anti-inflammation, and dispelling wind and dampness. It can quickly open up the body's meridians and expel wind, cold and dampness from the body. It is gentle on the skin.

[0004] A search revealed that existing mud moxibustion plasters are mostly used to treat pain-related occupational diseases (such as cervical spondylosis, frozen shoulder, lumbar disc herniation, etc.) or rheumatic diseases, such as: Patent application CN101897838A discloses a hot compress mud moxibustion device for external use on the human body and its application method. The mud moxibustion device's formula includes the following substances in weight percentages: 20-30% mineral energy white, yellow, green, red, and black mud powder; 10-20% plaster base; 15-25% traditional Chinese medicine powder; 25-35% beeswax; and 5-15% medical petroleum jelly. The plaster base formula is: 80-100ml sesame oil; 20-40ml essential oil; 5-25g red lead; 3-10g far-infrared nanoparticles; 5-15g menthol; 5-18g camphor; and mineral energy white... The formula includes 9-110g each of yellow, green, red, and black mud powder; the herbal formula is as follows: 20-40g of mugwort, 2-5g of saffron, 5-15g of *Ligusticum striatum*, 5-15g of Rhodiola rosea, 5-15g of snow lotus, 5-15g of sulfur, 10-20g of frankincense, 10-20g of myrrh, 5-15g of cinnamon twig, 5-15g of eucommia bark, 2-5g of asarum, 5-15g of chuanxiong rhizome, 5-15g of angelica pubescens root, 5-15g of processed aconite root, 5-15g of processed aconite root, 5-15g of angelica dahurica root, 5-15g of notopterygium root, 20-40g of *Spatholobus suberectus*, 5-15g of gentian root, 5-15g of peach kernel, and 5-15g of safflower. This invention, when applied to acupoints, can regulate the body's immune function, repair the nervous system, unblock meridians, and prevent pain recurrence.

[0005] Patent application CN102274410A discloses a composition for mud moxibustion to treat rheumatism, comprising 30-60 mg of beeswax, 300-500 mg of paraffin wax, 1000-1500 g of clay, 30-60 g of therapeutic minerals, 10-30 mg of sesame oil, 10-30 mg of essential oil, 40-60 g of honey, 5-15 g of angelica sinensis, and 5-10 g of chuanxiong. The formula consists of 5-20g of *Spatholobus suberectus*, 5-15g of *Cibotium barometz*, 5-20g of *Eucommia ulmoides*, 5-15g of *Taxillus chinensis*, 5-15g of *Codonopsis pilosula*, 5-20g of *Colla corii asini*, 5-15g of *Gastrodia elata*, 10-20g of *Clematis chinensis*, 10-20g of *Lycopodium clavatum*, 5-15g of *Erythrina variegata*, 5-15g of *Cinnamomum cassia*, 5-15g of *Piper kadsura*, 5-15g of *Liquidambar formosana*, 5-20g of *Caulis Lycopodium clavatum*, and 5-10g of *Zanthoxylum nitidum*. This formula has the effects of dispelling wind and cold, clearing the meridians, promoting qi and blood circulation, relieving pain, breaking up blood stasis, and strengthening muscles and bones.

[0006] Although the mud moxibustion ointment described in the above invention has a good therapeutic effect, the herbal formula is relatively complex. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a simple herbal formula for external application of mud moxibustion with good effects of dispelling wind and cold, clearing meridians and relieving pain, and its preparation method.

[0008] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A topical ointment for mud moxibustion is made from the following components in the indicated weight ratios: 15-30g of traditional Chinese medicine extract, 40-60g of mineral mud, 5-15g of beeswax, 2-8g of penetration enhancer, 1-5g of stabilizer, and 1-3g of dipotassium glycyrrhizate; among which, The herbal extract is prepared by the following method: *Smilax china* (or *Smilax china*), *Smilax china*, *Smilax china*, *Artemisia argyi*, and *Clematis chinensis* are weighed according to a weight ratio of 6-10:4-8:3-7:1-6:1-5. The herbs are pulverized, soaked in water, decocted, filtered, and the filtrate is concentrated to an extract with a relative density of 1.1-1.2 at 60°C.

[0009] Furthermore, in preparing traditional Chinese medicine extracts, the herbs are typically pulverized to 80-120 mesh, then soaked in water equivalent to 8-12 times their weight for 1-2 hours before being decocted. The decoction is performed over a low heat, and can be repeated 1-3 times, with each decoction preferably lasting 1-2 hours. The filtrates are collected, combined, and then concentrated to an extract with a relative density of 1.1-1.2 at 60°C.

[0010] In preparing traditional Chinese medicine extracts, the preferred ratio of each herb by weight is: 8 parts of *Gnaphalium affine*, 6 parts of *Gnaphalium affine*, 5 parts of *Gnaphalium affine*, 4 parts of *Artemisia argyi*, and 3 parts of *Hedyotis diffusa*; or 8 parts of *Gnaphalium affine*, 6 parts of *Gnaphalium affine*, 5 parts of *Gnaphalium affine*, 4 parts of *Artemisia argyi*, and 3 parts of *Hedyotis diffusa*.

[0011] Furthermore, the mineral mud can be mineral black mud, mineral yellow mud, or volcanic mud, etc. The mineral mud is sterilized (e.g., sterilized at 100~120℃ for 30~60 minutes) and sieved (100~200 mesh) before use.

[0012] Furthermore, the penetration enhancer can be a conventional choice from the prior art, such as azone, ethanol, menthol, or hyaluronic acid.

[0013] Furthermore, the stabilizer can be a conventional choice from the prior art, such as tocopherol or phytosterol.

[0014] Furthermore, the external application ointment for mud moxibustion is made from the following components in the indicated weight ratios: 20-30 parts of traditional Chinese medicine extract, 45-55 parts of mineral mud, 8-12 parts of beeswax, 3-6 parts of penetration enhancer, 2-4 parts of stabilizer, and 1-2 parts of dipotassium glycyrrhizate.

[0015] The preparation method of the external application ointment for mud moxibustion according to the present invention includes the following steps: 1) Weigh out the following herbs according to the weight ratio of 6~10:4~8:3~7:1~6:1~5:9-section wind (or small drill), zouma tai, da zuan, mugwort leaf and clematis root, crush them, soak them in water, decoct them, filter them, and concentrate the filtrate to an extract with a relative density of 1.1~1.2 at 60℃ to obtain the Chinese herbal extract. 2) Weigh out each component according to the above-mentioned proportions for the external application ointment for mud moxibustion, and set aside; 3) Heat the weighed beeswax until it melts, add mineral mud, mix well, then add traditional Chinese medicine extract, penetration enhancer and stabilizer at 50~60℃, mix well, then add dipotassium glycyrrhizate and stir well to obtain the external application ointment for mud moxibustion.

[0016] When using the mud moxibustion ointment described in this invention, heat the ointment to 45-50℃ (molten state), spread it evenly on the area to be treated (the thickness of the ointment should be 0.5-1cm), fix it with plastic wrap, and remove the ointment after 40-60 minutes. Furthermore, after applying the ointment to the area to be treated, massage techniques such as pushing, kneading, and acupressure can be applied to the surface of the ointment, which is more beneficial for relieving pain and other symptoms.

[0017] The external application ointment for mud moxibustion described in this invention begins to show effects after 1 to 3 days of use, and 10 days constitutes one course of treatment. For milder symptoms, 1 to 3 courses of treatment are usually sufficient to eliminate or effectively relieve the symptoms.

[0018] The mechanism of action of this invention: *Gnaphalium affine* or *Gnaphalium affine* dispels wind, invigorates blood circulation, and disperses stagnation; *Gnaphalium affine*, *Gnaphalium affine*, and *Gnaphalium affine* dispel wind and dampness, relax muscles and tendons, promote qi circulation, and relieve pain; *Artemisia argyi* acts as an auxiliary agent, warming the meridians, stopping bleeding, dispelling cold, and relieving pain; mineral mud invigorates blood circulation and removes blood stasis; beeswax detoxifies and relieves pain; the combined use of these ingredients achieves the effects of dispelling wind and dampness, warming the meridians and dispelling cold, invigorating blood circulation, removing blood stasis, promoting qi circulation, and relieving pain. The beneficial effects of this invention are: the ointment described in this invention has excellent effects on invigorating blood circulation, dispelling wind and dampness, and relieving pain caused by various reasons, and has a longer duration of warmth (65-75 minutes), can be conveniently applied to different parts of the body, and has an extremely low allergy rate. The formula of the traditional Chinese medicine extract is carefully developed from clinically proven prescriptions. It is not only simple in formula but also has excellent efficacy for symptoms such as pain, numbness, swelling, and difficulty in flexion and extension caused by muscle soreness, lumbar muscle strain, cervical spondylosis, intervertebral disc herniation, rheumatoid arthritis, and frozen shoulder.

[0019] Clinical efficacy summary of the ointment described in this invention for pain caused by various reasons (including muscle soreness, lumbar muscle strain, cervical spondylosis, intervertebral disc herniation, rheumatoid arthritis, osteoarthritis, frozen shoulder, etc.): I. General Information: This ointment was used to treat 280 cases in clinical practice, including 158 males and 122 females, aged 20 to 70 years.

[0020] II. Usage, Dosage, and Precautions: In clinical application, the external application ointment for moxibustion prepared according to the method described in Example 1 of this invention is used. The dosage is controlled by spreading the ointment to a thickness of 0.5-1 cm, and the amount is adjusted according to the patient's weight and age.

[0021] Usage: Heat in a microwave oven for 4-5 minutes, and apply a hot towel to the skin for 3 minutes. After the temperature is suitable for the body, apply it to the affected area or related acupoints. Remove after 40-60 minutes. Use once a day for 10 days as one course of treatment.

[0022] Precautions: This ointment is contraindicated on broken skin or acute purulent inflammation; it is contraindicated during pregnancy and menstruation; it is contraindicated on areas with impaired skin sensation, edema, infection, or open wounds; use with caution if you have allergies; it is contraindicated for patients with hypertension, heart disease, or cancer. Do not bathe within 6 hours after applying this ointment.

[0023] III. Efficacy Criteria: Recovery: Symptoms such as pain and swelling completely disappear, and functional activities return to normal.

[0024] Significant effect: Symptoms such as pain basically disappear, functional activities basically return to normal, and it does not interfere with daily life.

[0025] Effective: Symptoms such as pain are reduced, and functional activities are improved.

[0026] Ineffective: Symptoms such as pain do not improve, and functional impairment remains the same.

[0027] IV. Observation Results: In this clinical observation, after 1-3 courses of treatment, 152 patients experienced complete symptom disappearance, with normal or near-normal function, enabling them to participate in moderate physical labor or normal work, and no recurrence was observed during follow-up. Of the remaining patients, 82 showed significant symptom improvement, with functional activities essentially returning to normal, and were able to participate in light labor; 33 showed some symptom relief and functional activity improvement; and the remaining 3 showed no effect. The overall effective rate was 98.9%. During the application process, only 4 patients experienced slight redness at the application site, all of which resolved spontaneously. Detailed Implementation

[0028] To better explain the technical solution of the present invention, the present invention will be further described in detail below with reference to the embodiments, but the implementation of the present invention is not limited thereto.

[0029] The mineral mud used in the following examples was sterilized before use, specifically sterilized at 110°C for 45 minutes and then cooled and passed through a 200-mesh sieve.

[0030] The quantities mentioned in the following embodiments are by weight.

[0031] Example 1 1) Preparation of traditional Chinese medicine extracts: Weigh out the following herbs in a ratio of 8:6:5:4:3:9 ... 2) Weigh out 26 parts of Chinese herbal extract, 50 parts of mineral mud (specifically volcanic mud), 8 parts of beeswax, 3 parts of penetration enhancer (specifically azone), 2 parts of stabilizer (specifically tocopherol), and 1 part of dipotassium glycyrrhizate, and set aside. 3) Heat the weighed beeswax to 65°C until it melts, then add mineral mud and stir to mix evenly; then add traditional Chinese medicine extract, penetration enhancer and stabilizer at 55°C and stir to mix evenly; then cool down to 42°C and add dipotassium glycyrrhizate and stir to mix evenly to obtain the external application ointment for mud moxibustion.

[0032] After heating the finished product obtained in this example to 50°C, spread it on the part of the body to be treated (the thickness of the spread is 0.5~1cm). The duration of the warming (the duration of the warming refers to the time from the start of the application until the temperature of the ointment is lower than the body temperature and the patient feels cool) is 70 minutes.

[0033] The product obtained in this case was used on 280 patients undergoing treatment. Only 4 patients experienced slight redness at the application site, indicating an extremely low allergy rate.

[0034] Example 2 1) Preparation of traditional Chinese medicine extracts: Weigh out the following herbs in a ratio of 10:8:3:6:3:9:8:8:3:8:8:8:3:9:8 ... 2) Weigh out 15 parts of Chinese herbal extract, 40 parts of mineral mud (specifically, yellow mineral mud), 5 parts of beeswax, 6 parts of penetration enhancer (specifically, azone), 5 parts of stabilizer (specifically, tocopherol), and 2 parts of dipotassium glycyrrhizate, and set aside. 3) Heat the weighed beeswax to 70°C until it melts, then add mineral mud and stir to mix evenly; then add traditional Chinese medicine extract, penetration enhancer and stabilizer at 60°C and stir to mix evenly; then cool down to 40°C and add dipotassium glycyrrhizate and stir to mix evenly to obtain the external application ointment for mud moxibustion.

[0035] Example 3 1) Preparation of traditional Chinese medicine extracts: Weigh out small diamond, running horse fetus, big diamond, mugwort and clematis according to the weight ratio of 6:6:7:1:1, grind them to 100 mesh, add water equivalent to 12 times the weight of the Chinese medicine powder and soak for 2 hours, then simmer for 3 hours, filter, collect the filtrate, concentrate under reduced pressure to an extract with a relative density of 1.1 at 60℃, which is the Chinese medicine extract. 2) Weigh out 30 parts of Chinese herbal extract, 60 parts of mineral mud (specifically black mineral mud), 10 parts of beeswax, 8 parts of penetration enhancer (specifically hyaluronic acid), 3 parts of stabilizer (specifically tocopherol), and 1 part of dipotassium glycyrrhizate, and set aside. 3) Heat the weighed beeswax to 65°C until it melts, then add mineral mud and stir to mix evenly; then add traditional Chinese medicine extract, penetration enhancer and stabilizer at 55°C and stir to mix evenly; then cool down to 42°C and add dipotassium glycyrrhizate and stir to mix evenly to obtain the external application ointment for mud moxibustion.

[0036] Example 4 1) Preparation of traditional Chinese medicine extracts: Weigh out the following herbs according to the weight ratio of 8:4:5:3:5:9:4:5 ... 2) Weigh out 20 parts of Chinese herbal extract, 45 parts of mineral mud (specifically volcanic mud), 15 parts of beeswax, 2 parts of penetration enhancer (specifically ethanol), 1 part of stabilizer (specifically phytosterol), and 3 parts of dipotassium glycyrrhizate, and set aside. 3) Heat the weighed beeswax to 65°C until it melts, then add mineral mud and stir to mix evenly; then add traditional Chinese medicine extract, penetration enhancer and stabilizer at 50°C and stir to mix evenly; then cool down to 45°C and add dipotassium glycyrrhizate and stir to mix evenly to obtain the external application ointment for mud moxibustion.

[0037] Typical case: 1. Office workers with neck and shoulder strain Basic information: Ms. Zhang, 38 years old, works in an office and spends long hours at a desk.

[0038] Location and duration of discomfort: stiffness and soreness in the neck and shoulders, accompanied by headaches, lasting for about 2 years.

[0039] Treatment process: Heat the plaster and apply it to the back of the neck and the Jianjing acupoints on both sides. Secure it with plastic wrap for 60 minutes. The heat will continue to penetrate, and you will feel comfortable after application.

[0040] Improvement level: After 3 uses, neck rotation flexibility significantly increased. After one course of treatment (10 days), stiffness and soreness in the shoulders and neck improved by 80% compared to before use, and the frequency of headaches also decreased significantly. The patient stated, "I feel like a heavy burden has been lifted off my shoulders."

[0041] 2. New mothers experiencing lower back pain and coldness after childbirth Basic information: Ms. Li, 32 years old, 8 months postpartum.

[0042] Discomfort area and duration: Coldness, soreness and pain in the lumbosacral region and the entire back, which worsens when exposed to cold, lasting for six months.

[0043] Treatment process: Focus on applying the hot compress to the entire lumbosacral region (Mingmen and Baliao areas) and the bladder meridian on both sides of the spine. During the hot compress, you will feel the coldness being "forced out" from deep within, and you will sweat slightly all over your body.

[0044] Improvement level: By the 5th day of use, the cold sensation in the back was significantly reduced. After completing one course of treatment, the strength in the lower back was restored, the pain when holding the child was reduced by about 70%, and the sleep quality also improved due to the relief of back pain.

[0045] 3. Retired teachers with chronic knee osteoarthritis Basic information: Mr. Wang, 65 years old, retired teacher, enjoys mountain climbing.

[0046] Location and duration of discomfort: Morning stiffness in the knee joint, lasting for a long time; cold pain and heaviness in both knee joints, difficulty going up and down stairs, aggravated on rainy days, with a history of 3 years.

[0047] Treatment process: Apply the ointment to both knee joints and wrap them for 60 minutes, focusing on the knee joints and acupoints such as the "knee eye" and "crane's crown". After the hot compress, you will feel a warm, flowing sensation inside the joint.

[0048] Improvement level: After one course of treatment, the duration of morning stiffness in the knee joint was shortened, and the heaviness and pain during daily walking were reduced by about 60%. The patient reported that "my knees feel warmer and walking is easier."

[0049] 4. Sports enthusiasts who experience muscle strain after exercise Basic information: Zhao, 22 years old, college student, strained his leg after playing basketball.

[0050] Location and duration of discomfort: Acute strain of the left hamstring muscle, swelling, stinging pain, and limited mobility, lasting for 1 week.

[0051] Treatment process: After the acute phase (48 hours later), apply the ointment in the form of a long strip to the strained muscle for 60 minutes, combined with gentle stretching.

[0052] Improvement level: After three applications, swelling and stinging sensation subsided significantly. After one course of treatment, muscle flexibility was basically restored, mobility improved by 90%, and daily training resumed.

[0053] 5. Those who are physically weak and experience chronic fatigue in their limbs. Basic information: Aunt Liu, 56 years old, often feels lacking in energy.

[0054] Discomfort area and duration: The limbs are often sore, weak, and cold, especially the calves feel heavy as if filled with lead, which has lasted for several years.

[0055] Treatment process: Apply the patches alternately to the main muscle groups of the limbs (such as the outer side of the arms, the Chengshan acupoint on the back of the calves, etc.) and the Guanyuan acupoint on the abdomen to nourish vital energy. Each application should last for 60 minutes.

[0056] Improvement level: After one course of treatment, the weakness in the limbs was significantly improved, the heaviness in the calves was reduced by about 65%, the body felt much more "clear" and the fear of cold was also improved.

[0057] 6. Lumbar disc herniation Basic information: Mr. Liang, 55 years old, truck driver.

[0058] Location and duration of discomfort: I have had a herniated lumbar disc for several years. I sought medical treatment at the Department of Surgery of a tertiary hospital in Guilin. The doctor recommended surgery. I often experience lower back pain when walking, which radiates to my thighs. Sometimes the pain is so severe that it is unbearable.

[0059] Treatment process: Apply the ointment to the lumbosacral region for 60 minutes, including the Shenshu, Yaoyangguan, and Baliao acupoints.

[0060] Improvement level: After one course of treatment, lower back and leg pain was significantly relieved when walking.

[0061] 7. Rheumatoid arthritis Basic information: Ms. Li, 41 years old, a self-employed fresh fish vendor.

[0062] Location and duration of discomfort: Stiffness and pain in the joints of the limbs have been present for 5 years due to prolonged contact with cold water.

[0063] Treatment process: Apply the plaster to the entire joint for 60 minutes every day for 10 consecutive days, and avoid contact with cold water during this period.

[0064] Improvement level: Joint pain disappeared, and joints became flexible and not stiff.

Claims

1. An external application ointment for mud moxibustion, characterized by, It is made of the following weight ratio of components: Traditional Chinese medicine extract 15~30, mineral mud 40~60, beeswax 5~15, penetration enhancer 2~8, stabilizer 1~5, and dipotassium glycyrrhizinate 1~3. The traditional Chinese medicine extract is prepared by the following method: taking Jiuzi Feng or Xiaozuan, Zoumati, Dazuan, Ailu, and Tougucao in a weight ratio of 6~10:4~8:3~7:1~6:1~5, crushing, adding water, soaking, and decocting, filtering, and concentrating the filtrate to an extract with a relative density of 1.1~1.2 at 60℃.

2. The external ointment for mud moxibustion according to claim 1, wherein Jiuzi Feng or Xiaozuan, Zoumati, Dazuan, Ailu, and Tougucao are taken in a weight ratio of 8:6:5:4:

3.

3. The external ointment for mud moxibustion according to claim 1 or 2, wherein the penetration enhancer is azone, ethanol, menthol, or hyaluronic acid.

4. The external ointment for mud moxibustion according to claim 1 or 2, wherein the stabilizer is tocopherol or phytosterol.

5. The external ointment for mud moxibustion according to claim 1 or 2, wherein the weight ratio of the components is: traditional Chinese medicine extract 20~30, mineral mud 45~55, beeswax 8~12, penetration enhancer 3~6, stabilizer 2~4, and dipotassium glycyrrhizinate 1~2.

6. A preparation method of the external ointment for mud moxibustion according to claim 1, comprising the following steps: 1) taking Jiuzi Feng or Xiaozuan, Zoumati, Dazuan, Ailu, and Tougucao in a weight ratio of 6~10:4~8:3~7:1~6:1~5, crushing, adding water, soaking, and decocting, filtering, and concentrating the filtrate to an extract with a relative density of 1.1~1.2 at 60℃, to obtain the traditional Chinese medicine extract; 2) taking the components in the ratio according to claim 1; 3) heating the beeswax to melt, adding the mineral mud, mixing uniformly, then adding the traditional Chinese medicine extract, the penetration enhancer, and the stabilizer at 50~60℃, mixing uniformly, and then adding the dipotassium glycyrrhizinate, and stirring uniformly, to obtain the external ointment for mud moxibustion.