Cream paper added with turpinia arguta leaf extracting solution and preparation method of cream paper

Abstract

The invention discloses cream paper added with a turpinia arguta leaf extracting solution and a preparation method of the cream paper, and relates to the technical field of cream paper. The cream paper added with the turpinia arguta leaf extracting solution consists of base paper and a cream layer coated on at least one surface of the base paper, the cream layer is prepared from the following raw materials in parts by mass: 1-20 parts of a turpinia arguta leaf extracting solution, 5-30 parts of a humectant, 3-25 parts of an oily component, 1-10 parts of an emulsifier, 0.1-5 parts of a thickening stabilizer, 0.5-1.5 parts of an antioxidant and bacteriostatic active component, 0.1-5 parts of a skin soothing agent and the balance of deionized water which is added to 100 parts. According to the cream paper, the limitation that existing cream paper is mainly based on basic moisturizing is broken through, the turpinia arguta leaf extracting solution is matched with the specific antioxidant and bacteriostatic active ingredients, the multiple functions of resisting bacteria, resisting oxidation and moisturizing are combined, the irritation of a synthetic antibacterial / antioxidant is avoided, and the natural and mild consumer demand is better met.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of cream paper, and particularly relates to a cream paper added with extract of leaves of Melia toosendan and a preparation method thereof. BACKGROUND

[0002] With the popularity of consumption upgrading and skin care concepts, cream paper has been widely used in scenarios such as maternal and infant care, daily wiping for sensitive skin, and skin care in dry seasons in autumn and winter due to the combination of softness of base paper and moisturizing property of cream layer, and the market demand continues to grow. However, the functional development of existing cream paper is mainly focused on basic moisturizing, and there are obvious short boards in the core performance of antibacterial and antioxidant, which is difficult to meet the high requirements of consumers on product safety and long-term effectiveness.

[0003] From the perspective of antibacterial performance, the cream layer of ordinary cream paper is mainly composed of moisturizing ingredients such as glycerol and panthenol, and lacks targeted antibacterial design. In daily use, cream paper is easy to contact with skin secretions, environmental humidity and the like, which provides conditions for the breeding of bacteria (such as Escherichia coli and Staphylococcus aureus) and mold, and long-term use may cause skin redness, itching and the like, especially for infants and children and sensitive skin groups with weak skin barrier. Although some products add phenoxyethanol and synthetic antibacterial agents such as nipagin esters, there are problems such as strong irritation and questionable long-term use safety, which is contrary to the consumer demand for “gentle skin care”.

[0004] In the antioxidant dimension, oily ingredients such as jojoba seed oil and squalane in the cream layer, and moisturizing agents such as sodium hyaluronate, are easy to be oxidized and degraded in the process of storage (such as light and high temperature) and use. Oxidation not only causes the cream layer to produce odor and rough texture, but also reduces the moisturizing effect, and even generates aldehydes, ketones and other irritating oxidation products, which damage the skin barrier. The synthetic antioxidants (such as BHT and BHA) commonly used in existing products can delay oxidation, but consumers' preference for “natural ingredients” is increasing, and the acceptance of such ingredients is gradually declining.

[0005] In summary, the current cream paper market urgently needs a product that takes into account gentleness, naturalness and high-efficiency antibacterial and antioxidant performance, solves the pain points of existing technology by introducing natural active ingredients, and meets the use needs of different groups of people for functional cream paper. SUMMARY

[0006] In view of the problems that existing cream paper mainly focuses on basic moisturizing, and the antibacterial and antioxidant performance is insufficient, and some products use synthetic antibacterial and antioxidant agents, which have problems such as irritation, questionable safety and low consumer acceptance, the present application provides a cream paper added with extract of leaves of Melia toosendan and a preparation method thereof. The antibacterial and antioxidant effects of the product are improved by matching antibacterial and antioxidant active ingredients with specific structures, and the gentleness and naturalness are taken into account, so as to meet the use needs of groups of people such as mothers and infants, and sensitive skin.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is: a cream paper with added Rhizoma Cynanchi var. sarmentosum leaf extract, comprising a base paper and a cream layer coated on at least one surface thereof; the cream layer is made of raw materials comprising the following proportions by weight: 1-20 parts of *Syzygium aromaticum* leaf extract, 5-30 parts of moisturizer, 3-25 parts of oily components, 1-10 parts of emulsifier, 0.1-5 parts of thickener and stabilizer, 0.5-1.5 parts of antioxidant and antibacterial active ingredients, 0.1-5 parts of skin soothing agent, and deionized water to 100 parts; The structure of the antioxidant and antibacterial active ingredient is the compound shown in Formula 1: The structure of Equation 1 is as follows: ; In Formula 1, R1 is a substituent, and R1 is selected from any one of H, cyano, methyl, ethyl, propyl, and ethynyl.

[0008] Furthermore, the extract of *Syzygium aromaticum* leaves is prepared by the following method: dried *Syzygium aromaticum* leaves are pulverized to obtain *Syzygium aromaticum* leaf powder, and a mixed solution of water and ethanol with a mass ratio of 10 parts by weight of the *Syzygium aromaticum* leaf powder is added as the extraction solvent. The mixture is refluxed at 80-95℃ for 3-5 hours, filtered, and the filtrate is dried to obtain the extract of *Syzygium aromaticum* leaves.

[0009] Furthermore, the moisturizer is one or more of glycerin, propylene glycol, butylene glycol, sodium hyaluronate, panthenol, ceramide, trehalose, and polyglutamic acid.

[0010] Furthermore, the oily component is one or more of jojoba seed oil, squalane, shea butter, and cetearyl alcohol.

[0011] Furthermore, the emulsifier is one or more of cetearyl alcohol olive oil ester, PEG-100 stearate, glyceryl stearate, and sorbitan olive oil ester.

[0012] Furthermore, the thickening stabilizer is carbomer and / or xanthan gum.

[0013] Furthermore, the skin soothing agent is one or more of dipotassium glycyrrhizate, bisabolol, and allantoin.

[0014] Furthermore, the antioxidant and antibacterial active ingredient is any one of the compounds shown in the following structures:

[0015] A method for preparing a cream paper with added Rhizoma Cynanchi var. sarmentosum leaf extract includes the following steps: S1. Preparation of oil phase: The oily component and 1 / 2 part by mass of the emulsifier are added to a stirring container, and the mixture is heated to 70-85°C and stirred continuously for 10-20 minutes at a stirring speed of 300-500 rpm to obtain the oil phase; S2. Aqueous phase preparation: Add the deionized water, humectant, and thickening stabilizer to another stirring container. Heat the mixture to 75-90℃ at a stirring speed of 500-800 rpm and continue stirring for 15-25 min. After the thickening stabilizer is completely dispersed and there are no obvious particles, add the extract of Rhizoma Sinensis var. sarcodactylis. Continue stirring for 5-10 min until the system is homogeneous to obtain the aqueous phase. S3. Emulsification treatment: Adjust the temperature of the oil phase and the water phase to 70-80℃, slowly pump the oil phase into the water phase at a rate of 5-10mL / min, and at the same time start high-speed stirring, control the stirring speed to 1000-1500rpm, and continue emulsification for 15-30min to form a preliminary cream matrix. S4. Low-temperature preparation: Transfer the preliminary cream base to a cooling mixing tank and allow it to cool naturally at a stirring speed of 300-500 rpm. When the system temperature drops to 40-50℃, add the antioxidant and antibacterial active ingredients and skin soothing agent, and continue stirring for 10-15 minutes to obtain the finished cream. S5. Coating and Curing: Using roller coating or comma-shaped doctor blade coating equipment, the finished cream is evenly coated onto at least one surface of the base paper, controlling the coating amount to be 5-20 g / m². 2 The coated base paper is then sent into a hot air drying tunnel and dried at 50-70℃ for 10-25 minutes. After the cream layer is completely cured, it is cooled to 20-25℃ by cold air to obtain a cream paper with added mountain jasmine leaf extract.

[0016] Furthermore, S3 and S4 are carried out under a nitrogen atmosphere.

[0017] Furthermore, the base paper needs to be pretreated before use: the base paper is equilibrated in an environment of 45-55℃ and 40%-50% relative humidity for 2-4 hours to eliminate the internal moisture gradient of the base paper and avoid wrinkles or cracks in the cream layer after coating.

[0018] The formula described in this invention systematically solves three major technical problems—single basic moisturizing function, insufficient antibacterial properties, and weak antioxidant properties—through the synergistic effect of its various components, while ensuring the product's gentleness and naturalness. Specifically, the formula centers on natural mountain jasmine leaf extract and specific structured antioxidant and antibacterial active ingredients, constructing a multi-dimensional synergistic network: In terms of antibacterial properties, the natural broad-spectrum antibacterial background provided by the mountain jasmine leaf extract, combined with the highly efficient and specific antibacterial effects of the specific active ingredients, forms a dual mechanism of "natural broad-spectrum barrier" and "highly efficient specific targeting," achieving highly efficient antibacterial effects at low doses and avoiding dependence on high-concentration synthetic antibacterial agents; In terms of antioxidant properties, the natural polyphenolic compounds in the mountain jasmine leaf extract, combined with the powerful antioxidant capacity of the specific active ingredients, form a complex antioxidant system, synergistically scavenging free radicals and blocking lipid peroxidation chain reactions. Combined with nitrogen protection in the preparation process to physically isolate oxygen, this ensures the stability of the cream layer; Simultaneously, moisturizers, oily ingredients, and emulsifiers synergistically construct a complete "hydration-locking-repair" skin barrier system, while skin soothing agents, combined with natural extracts and the moisturizing and repairing system, further enhance the product's gentle and soothing effects. Ultimately, the formula achieves the comprehensive goal of long-lasting safety, gentleness, and stable performance of the cream sheet through the synergistic enhancement of the antibacterial, antioxidant, and basic moisturizing and repairing functions of each component.

[0019] Compared with the prior art, the beneficial effects of the present invention are: 1. Functional Dimension: Breaking through the limitations of existing cream sheets that mainly focus on basic moisturizing, this product combines extracts of Rhododendron molle leaf with specific antioxidant and antibacterial active ingredients to achieve a multi-functional combination of antibacterial, antioxidant, and moisturizing properties. It also avoids the irritation of synthetic antibacterial / antioxidant agents, making it more in line with the consumer demand for natural and gentle products.

[0020] 2. Preparation process dimension: The pretreatment of base paper, emulsification environment control (nitrogen protection) and coating and curing parameters have been optimized. Compared with the existing process, which may have uneven coating and poor cream stability, it can more accurately control the uniformity and curing effect of the cream layer, reduce problems such as cream layer wrinkles and cracks, and improve product quality stability.

[0021] 3. Synergistic Ingredient Dimension: A synergistic system of moisturizers, oily ingredients, skin soothing agents and core active ingredients has been constructed, which not only enhances the skin care effect of "hydration-moisturization-repair", but also enhances the antibacterial durability and antioxidant stability through the synergistic effect of multiple ingredients, making it more suitable for mothers and babies, sensitive skin and other groups with higher requirements for product safety and gentleness. Attached Figure Description

[0022] Figure 1 This is the NMR spectrum of the antioxidant and antibacterial active ingredient 1 of the present invention. Detailed Implementation

[0023] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Preparation Example 1 Preparation of antioxidant and antibacterial active ingredient 1: .

[0025] Step 1: Add 10 g of compound 1, 7.20 g of compound 2, and 120 ml of tetrahydrofuran to a dry reactor. After stirring thoroughly, slowly add 3.40 ml of concentrated sulfuric acid and heat to 80 °C for 6 h. After the reaction is complete, adjust the pH of the solution to neutral with 0.1 mol / L sodium bicarbonate aqueous solution, separate the layers, and retain the organic phase. Dry the organic phase using a rotary evaporator, purify it by silica gel column chromatography using a mixed solution of petroleum ether and ethyl acetate as the eluent, and then dry it again using a rotary evaporator to obtain 11.37 g of compound 3. The mass spectrometry of compound 3 is MS+1:459.

[0026] Step 2: Under nitrogen protection, 11.37 g of compound 3, 4.55 g of compound 4, 0.99 g of sodium hydroxide, 0.27 g of palladium acetate, 0.25 g of tri-tert-butylphosphine, and 140 ml of toluene were added to a dry reactor. The mixture was stirred until homogeneous, heated to 120 °C, and refluxed for 12 h. After the reaction was completed, the temperature was slightly lowered, and the mixture was filtered through diatomaceous earth to remove salts and catalyst. The filtrate was cooled to room temperature, washed three times with water, and the organic phase was retained. The aqueous phase was then extracted with ethyl acetate. The combined organic phases were dried with anhydrous magnesium sulfate, and the solvent was removed using a rotary evaporator. The mixture was purified by silica gel column chromatography using a mixture of petroleum ether and ethyl acetate as the eluent. The final product was evaporated to dryness using a rotary evaporator to obtain 9.73 g of antioxidant and antibacterial active ingredient 1. The mass spectrometry (MS+1): 516 of antioxidant and antibacterial active ingredient 1 was obtained. (NMR data are shown below.) Figure 1 .

[0027] Preparation Examples 2-5 In Preparation Examples 2-5, antioxidant and antibacterial active ingredients 2 and 5 were prepared sequentially, following the preparation method of Preparation Example 1, except that compound 2 was replaced, and the rest remained the same as in Preparation Example 1. See Table 1 for details.

[0028] Table 1

[0029] Example 1

[0030] Preparation of a cream paper with added Rhizoma Spatholobi leaf extract: 1. Raw material components: Mountain sweet clover leaf extract: homemade, 5 portions; Moisturizer: A mixture of 10 parts glycerin and 5 parts sodium hyaluronate; Oily components: a mixture of 8 parts jojoba seed oil and 5 parts squalane; Emulsifier: a mixture of 3 parts cetearyl alcohol olive oil ester and 2 parts PEG-100 stearate; Thickening and stabilizing agent: selected from 0.8 parts of carbomer; Antioxidant and antibacterial active ingredients: 1 part of antioxidant and antibacterial active ingredient 1 obtained from Preparation Example 1; Skin soothing agent: selected from 1 part dipotassium glycyrrhizate; Deionized water, 59.2 parts; Base paper: virgin wood pulp soft base paper (basis weight 40g / m²) 2 ).

[0031] 2. Preparation method: 2.1 Preparation of *Syzygium aromaticum* leaf extract: Dried *Syzygium aromaticum* leaves (moisture content ≤8%) were pulverized to 80 mesh using a high-speed pulverizer to obtain *Syzygium aromaticum* leaf powder. Extraction solvent (water to ethanol volume ratio 1:1) was added in an amount 10 times the mass of the *Syzygium aromaticum* leaf powder. The mixture was transferred to a three-necked flask equipped with a reflux device, heated to 90℃, and refluxed at this temperature for 4 hours. After extraction, the mixture was filtered through a 300-mesh filter cloth, and the filtrate was collected. The filtrate was placed in a rotary evaporator and concentrated at 60℃ and -0.09 MPa vacuum until no solvent distilled off. It was then dried in a vacuum drying oven (55℃, -0.08 MPa) to constant weight to obtain the *Syzygium aromaticum* leaf extract.

[0032] 2.2 Pretreatment of base paper: Place the virgin wood pulp soft base paper in a constant temperature and humidity chamber, set the temperature to 50℃ and the relative humidity to 45%, and equilibrate for 3 hours to eliminate the internal moisture gradient of the base paper and avoid wrinkles or cracks in the cream layer during the subsequent coating process. After pretreatment, take it out and place it in a clean and dry environment for later use.

[0033] 2.3 Preparation of the oil phase: Add the oily component and 1 / 2 part by mass of emulsifier into a stainless steel stirring container, turn on the stirring device, set the stirring speed to 400 rpm, and slowly heat to 75°C. Continue stirring at this temperature for 15 min until the system is a homogeneous and transparent oily liquid. Stop stirring to obtain the oil phase.

[0034] 2.4 Preparation of the aqueous phase: In a separate stainless steel stirring container, add 59.2 parts of deionized water and 0.8 parts of humectant and thickening stabilizer carbomer. Turn on the stirring device, set the stirring speed to 600 rpm, heat to 80℃, and continue stirring for 20 min, observing the state of the system during this period. After the carbomer is completely dispersed and there are no obvious particles, add 5 parts of the *Syzygium aromaticum* leaf extract prepared in step 2.1, and continue stirring for 8 min until the system is a homogeneous and transparent aqueous solution. Stop stirring to obtain the aqueous phase.

[0035] 2.5 Emulsification (under nitrogen atmosphere): Nitrogen gas was introduced into the stirring container containing the aqueous phase to replace the air in the container. Then, the temperature of the oil phase was adjusted to 75℃, and the oil phase was slowly pumped into the aqueous phase at a rate of 8 mL / min using a peristaltic pump. At the same time, the stirring speed was increased to 1200 rpm, and emulsification was continued for 20 min under nitrogen protection to ensure no layering or particles. After emulsification, a uniform and delicate preliminary cream matrix was obtained.

[0036] 2.6 Low-temperature preparation (under nitrogen atmosphere): While maintaining nitrogen gas flow, transfer the initial cream base to a mixing tank with a cooling jacket. Set the mixing speed to 400 rpm and allow circulating cooling water to flow through the jacket for natural cooling. When the system temperature drops to 45°C, add 1 part of antioxidant and antibacterial active ingredient and 1 part of skin soothing agent dipotassium glycyrrhizate. Continue mixing for 12 minutes to ensure uniform dispersion of all ingredients. Stop mixing and nitrogen gas flow to obtain the finished cream.

[0037] 2.7 Coating and Curing: Using a comma-shaped doctor blade coating device, the finished cream is evenly coated on both sides of the pretreated base paper from step 2.2. The coating amount is controlled to be 12 g / m² by adjusting the doctor blade gap. 2 (Single-sided coating amount 6g / m²); The coated base paper is sent into the hot air drying tunnel, the drying temperature is set to 60℃, the drying time is 18min, until the cream layer is completely cured; Then the base paper is sent into the cold air cooling section, clean cold air at 22℃ is introduced, and the base paper temperature is cooled to the same as the ambient temperature (22-25℃). After slitting and winding, a cream paper with added mountain jasmine leaf extract is obtained.

[0038] Examples 2-5 The preparation of a cream paper with added Rhizoma Cynanchi var. sarcodactylis extract is carried out by referring to the preparation method of Example 1, except that the antioxidant and antibacterial active ingredient 1 is replaced sequentially with antioxidant and antibacterial active ingredients 2-5, and the rest is the same as in Example 1.

[0039] Comparative Example 1 A cream paper with added Rhizoma Spatholobi extract was prepared by referring to the preparation method of Example 1, except that the antioxidant and antibacterial active ingredient 1 was replaced with... (Quinolone antibacterial agent, 19562-30-2), the rest is the same as in Example 1.

[0040] Comparative Example 2 The preparation of a cream paper with added Rhizoma Cynanchi var. sarcodactylis extract is carried out according to the preparation method of Example 1, except that the antioxidant and antibacterial active ingredient 1 is replaced with berberine, and the rest is the same as in Example 1.

[0041] Comparative Example 3 The preparation of a cream paper with added mountain jasmine leaf extract is carried out according to the preparation method of Example 1, except that the antioxidant and antibacterial active ingredient 1 is replaced with tea tree oil, and the rest is the same as in Example 1.

[0042] Comparative Example 4 The preparation of a cream paper with added Rhizoma Cynanchi var. sarmentosum extract is carried out according to the preparation method of Example 1, except that the antioxidant and antibacterial active ingredient 1 is not added, and the rest is the same as in Example 1.

[0043] Performance testing: Sample: A cream paper with added Rhizoma Spathiphyllum leaf extract prepared in the Examples and Comparative Examples.

[0044] 1. Antibacterial performance test: Standard strains of Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 6538) were cultured in nutrient broth medium until the logarithmic growth phase (OD). 600 =0.6~0.8), diluted with sterile physiological saline to 1×10 6 Prepare a bacterial suspension at CFU / mL. Add 100 μL of the bacterial suspension evenly to the sample surface, cover with a sterile polyethylene film (15 mm × 15 mm area to prevent bacterial loss), and incubate at 37℃ and 90% relative humidity for 24 h. After incubation, transfer the sample to a centrifuge tube containing 10 mL of sterile physiological saline, shake for 10 min (200 rpm) to elute viable bacteria, and serially dilute the eluent (10 CFU / mL). -1 ~10 -3 ), take 100 μL of each sample and spread it on nutrient agar plates. After incubation at 37℃ for 48 h, count the number of colonies (CFU). Inhibition rate (%) = (number of colonies in blank sample - number of colonies in test sample) / number of colonies in blank sample × 100. The data are shown in Table 2.

[0045] 2. Antioxidant performance test - Peroxide value (POV) determination: The sample was divided into two parts: one part was used for immediate testing and the other part was used for accelerated aging testing (stored in a constant temperature and humidity chamber at 60℃ and 75% relative humidity for 60 days). Take 2g of cream sample, add 20mL of chloroform-glacial acetic acid mixture (volume ratio 2:3), shake to dissolve, add 1mL of saturated potassium iodide solution, and let stand in the dark for 5min; titrate with 0.01mol / L sodium thiosulfate standard solution until pale yellow, add 1mL of starch indicator, and continue titrating until the blue color disappears, and record the volume consumed (V); blank test: without adding sample, repeat the above steps and record the blank consumption volume (V0); POV value: unit is g / 100g, calculation formula: POV=(V-V0)×c×0.1269 / m×100 (c is the concentration of sodium thiosulfate, m is the sample mass); judgment criteria: after 60 days of storage, a POV increase ≤0.1g / 100g is "excellent antioxidant stability", an increase of 0.1~0.3g / 100g is "good", and an increase >0.3g / 100g is "poor". The data are shown in Table 2.

[0046] Table 2.

[0047] Bacteriostatic rate (%) Escherichia coli Bacteriostatic rate (%) Staphylococcus aureus POV value (g / 100g) immediate test POV value (g / 100g) after aging POV increase value (g / 100g) Antioxidant stability determination Example 1 98 99 0.02 0.1 0.08 Excellent Example 2 97 98 0.02 0.09 0.07 Excellent Example 3 99 99 0.03 0.11 0.08 Excellent Example 4 98 99 0.02 0.1 0.08 Excellent Example 5 97 98 0.03 0.12 0.09 Excellent Comparative Example 1 92 93 0.03 0.18 0.15 Good Comparative Example 2 87 88 0.04 0.22 0.18 Good Comparative Example 3 82 83 0.05 0.27 0.22 Good Comparative Example 4 23 25 0.06 0.38 0.32 Poor The comprehensive performance of Examples 1-5 (using the specific antioxidant and antibacterial active ingredients of this invention) is significantly better than that of Comparative Examples 1-4: In terms of antibacterial properties, the examples showed an inhibition rate of 97%-98% against Escherichia coli and 8%-99% against Staphylococcus aureus, which is much higher than that of Comparative Example 1 (quinolones, 92%-93%), Comparative Example 2 (berberine, 87%-88%), and Comparative Example 3 (tea tree oil, 82%-83%), and far exceeds that of Comparative Example 4 (23%) without antioxidant and antibacterial ingredients. (%-25%)); In terms of antioxidant properties, the immediate POV value of the examples was 0.02-0.03 g / 100g, and the POV increase after aging was only 0.07-0.09 g / 100g, both of which were judged as "excellent". In contrast, the increase in comparative examples 1-3 was 0.15-0.22 g / 100g ("good"), and the increase in comparative example 4 was 0.32 g / 100g ("poor"). It can be seen that the specific antioxidant and antibacterial active ingredients of the present invention can effectively improve the antibacterial and antioxidant properties of the cream paper.

[0048] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A cream paper added with an extract of Melia azedarach leaves, characterized in that, Consists of a base paper and a cream layer coated on at least one surface thereof; the cream layer is made of raw materials in the following mass ratio: 1-20 parts of extract of Melia toosendan leaves, 5-30 parts of moisturizing agent, 3-25 parts of oily ingredient, 1-10 parts of emulsifier, 0.1-5 parts of thickening stabilizer, 0.5-1.5 parts of anti-oxidation and antibacterial active ingredient, 0.1-5 parts of skin soothing agent, and deionized water added to 100 parts; The anti-oxidation and antibacterial active ingredient is a compound as shown in formula 1: The structure of Formula 1 is: ; R1 in formula 1 is a substituent selected from any one of H, cyano, methyl, ethyl, propyl and ethynyl.

2. The cream paper added with the extract of the leaf of Murraya paniculata according to claim 1, characterized in that, The extract of Melia toosendan leaves is prepared by the following method: after the dried leaves of Melia toosendan are crushed to obtain leaf powder, 10 times the mass of a mixed solution of water and ethanol is added as an extraction solvent, and the mixture is refluxed at 80-95°C for 3-5 hours, filtered, and the filtrate is dried to obtain the extract of Melia toosendan leaves.

3. The cream paper added with the extract of the leaf of Murraya paniculata according to claim 1, characterized in that, The moisturizing agent is one or more of glycerol, propylene glycol, butylene glycol, sodium hyaluronate, panthenol, ceramide and trehalose.

4. The cream paper added with the extract of the leaf of Murraya paniculata according to claim 1, characterized in that, The oily ingredient is one or more of jojoba seed oil, squalane, shea butter and cetylstearyl alcohol.

5. The cream paper according to claim 1, wherein the cream paper is characterized by, The emulsifier is one or more of cetylstearyl alcohol olive ester, PEG-100 stearate, glyceryl stearate and sorbitan olivate.

6. The cream paper according to claim 1, wherein the cream paper is characterized by, The thickening stabilizer is carbomer and / or xanthan gum. The skin soothing agent is one or more of dipotassium glycyrrhizinate, bisabolol and allantoin.

7. The cream paper according to claim 1, wherein the cream paper is characterized by, The anti-oxidation and antibacterial active ingredient is any one of the compounds shown in the following structures:

8. A method of preparing a cream paper added with an extract of Melia azedarach leaves according to any one of claims 1 to 7, characterized in that, The method comprises the following steps: S1. Oil phase preparation: the oily ingredient and 1 / 2 mass of the emulsifier are added to a stirring container, the temperature is raised to 70-85°C under stirring at a speed of 300-500 rpm, and the stirring is continued for 10-20 min to obtain an oil phase; S2. Water phase preparation: the deionized water, moisturizing agent and thickening stabilizer are added to another stirring container, the temperature is raised to 75-90°C under stirring at a speed of 500-800 rpm, and the stirring is continued for 15-25 min until the thickening stabilizer is completely dispersed and no obvious particles are present, then the extract of Melia toosendan leaves is added, and the stirring is continued for 5-10 min until the system is uniform to obtain a water phase; S3. Emulsification: the temperature of the oil phase and the water phase is adjusted to 70-80°C, the oil phase is slowly pumped into the water phase at a rate of 5-10 mL / min while the high-speed stirring is started, the stirring speed is controlled to be 1000-1500 rpm, and the emulsification is continued for 15-30 min to form a preliminary cream base; S4. Low-temperature blending: the preliminary cream base is transferred to a cooling stirring tank, the stirring is performed at a speed of 300-500 rpm for natural cooling, and when the temperature of the system drops to 40-50°C, the anti-oxidation and antibacterial active ingredient and the skin soothing agent are added, and the stirring is continued for 10-15 min to obtain a finished cream; S5. Coating and curing: the finished cream is evenly coated on at least one surface of the base paper by using a roller coating or comma blade coating device, and the coating amount is controlled to be 5-20 g / m 2 ; then the coated base paper is sent into a hot air drying tunnel, dried at 50-70°C for 10-25 min, and cooled to 20-25°C by cold air after the cream layer is completely cured, thereby obtaining a cream paper added with the extract of Murraya paniculata leaves.

9. The method of claim 8, wherein the cream paper is prepared by adding the extract of the leaf of Murraya paniculata to the paper. The S3 and S4 are performed under a nitrogen atmosphere. ​ 10. The method of claim 8, wherein the cream paper is prepared by adding the extract of the leaf of Murraya paniculata to the paper. The base paper needs to be pretreated before use: the base paper is balanced in an environment with a temperature of 45-55°C and a relative humidity of 40%-50% for 2-4h, so as to eliminate the internal moisture gradient of the base paper and avoid wrinkles or cracks in the cream layer after coating. ​

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