Bacteriostatic acarus-killing laundry detergent and preparation method thereof

Abstract

The invention relates to the technical field of daily chemicals, in particular to a bacteriostatic and acarus-killing laundry detergent and a preparation method thereof. According to the laundry detergent, a multi-stage microcapsule technology is adopted, and intelligent controlled release of sterilization components is achieved through a gradient silicon shell structure and a chitosan quaternary ammonium salt nano-micelle system; the preparation method comprises the following steps: preparing an enzyme preparation and a protective agent into an internal phase solution, and performing membrane emulsification on the internal phase solution and a sodium alginate shell phase solution to form microcapsules; a single silicon shell structure is constructed through modification of a silane coupling agent; then reacting with a composite nano-micelle dispersion liquid and water glass to form a composite microcapsule; and finally, compounding with a surfactant to obtain a finished product. The invention solves the technical problem that the bio-enzyme and the bactericide in the traditional laundry detergent are difficult to coexist, and the product has the characteristics of high-efficiency bacteriostasis and acarus killing, long-acting enzyme activity maintenance and low skin irritation, and can meet the diversified requirements from daily cleaning to professional sterilization.

Description

Technical Field

[0001] This invention relates to the field of daily chemical technology, specifically to an antibacterial and anti-mite laundry detergent and its preparation method. Background Technology

[0002] As consumers' demands for clothing cleaning continue to rise, traditional laundry detergents face significant challenges in terms of functionality. Existing technologies mainly suffer from the following key problems: insufficient bactericidal efficacy: conventional bactericides such as quaternary ammonium salts are easily inactivated by surfactants and cannot penetrate the cuticle of mites; poor enzyme stability: biological enzymes such as proteases are easily denatured by surfactants in the washing system, accelerating aging, and the activity retention rate is usually less than 60% after 6 months; conflicting irritation levels and poor functional synergy, etc.

[0003] Existing solutions to these problems have significant limitations: while simple compounding of bactericides can improve immediate effects, they lack long-lasting efficacy. Furthermore, the coexistence stability of enzymes and bactericides remains a technical challenge. Enzyme molecules such as proteases and lipases have numerous active groups on their surfaces, making them highly susceptible to charge interactions with cationic bactericides like quaternary ammonium salts and polyhexamethylene biguanide, leading to conformational changes and inactivation of the enzyme protein. Simultaneously, bactericides can also reduce their bactericidal efficacy due to binding to enzyme molecules. Using expensive slow-release materials such as cyclodextrin derivatives significantly increases costs. Especially for people with sensitive skin, existing products struggle to simultaneously meet the dual needs of highly effective cleansing and gentle care.

[0004] Therefore, developing a novel laundry detergent system that can simultaneously protect enzyme activity, maintain bactericidal efficacy, and provide good sterilization effects on clothes, washing machines, and drainage pipes has become a pressing technical challenge in this field. Summary of the Invention

[0005] In view of this, the purpose of this invention is to propose an antibacterial and anti-mite laundry detergent and its preparation method, so as to solve the problem that biological enzymes such as protease and lipase and bactericidal factors such as quaternary ammonium salts in traditional laundry detergents are difficult to coexist in the same liquid system for a long time and maintain their efficacy.

[0006] To achieve the above objectives, the present invention provides a method for preparing an antibacterial and anti-mite laundry detergent, comprising the following steps:

[0007] S1: Glycerol, sorbitol, polyvinylpyrrolidone K30, borax, calcium chloride and deionized water are stirred at 25°C for 20 min, and then alkaline serine protease, lipase and wash-resistant amylase are added and gently stirred to obtain the inner phase solution.

[0008] S2: Dissolve sodium alginate and sodium polyaspartate in deionized water and stir at 25°C for 20-30 min to obtain a shell phase solution;

[0009] S3: Calcium chloride is dissolved in deionized water and placed as a continuous phase in a circulating membrane emulsification device. The inner phase solution and the shell phase solution are combined in equal volumes and pushed through the membrane surface for 30 minutes under a transmembrane pressure difference of 0.2 MPa using a ceramic membrane with a pore size of 2 μm to obtain a microcapsule dispersion with a particle size of 2-4 μm.

[0010] S4: Tetraethoxysilane was mixed with anhydrous ethanol, deionized water and glacial acetic acid, and 3-aminopropyltriethoxysilane was added. The mixture was then slowly added dropwise to the microcapsule dispersion at 25°C and stirred for 2 hours to obtain a single-silica-shell modified microcapsule dispersion.

[0011] S5: Dissolve N,N,N-trimethyl chitosan and hydroxypropyltrimethylammonium chitosan in deionized water, add sodium citrate and citric acid, adjust the pH to 6, add polyhexamethylene biguanide hydrochloride and stir for 10-20 min, then add decyl dimethyl ammonium chloride and sonicate for 5-10 min to obtain a composite nanomicelle dispersion.

[0012] S6: Dissolve sodium silicate nonahydrate in deionized water to form a water glass solution. Then, adjust the pH of the single-silica shell modified microcapsule dispersion to 10 using sodium carbonate. Add the composite nano micelle dispersion, then slowly add the water glass solution and react at 30℃ for 60-90 min while simultaneously atomizing and spraying calcium chloride solution to obtain the composite microcapsule dispersion.

[0013] S7: Add the dodecyl glucoside solution, myristol polyoxyethylene ether sodium sulfate solution, lauryl polyoxyethylene ether sodium sulfate solution, potassium fatty acid soap, and citric acid sequentially at room temperature and stir evenly. Then add the composite microcapsule dispersion and add deionized water. Stir evenly and defoam to obtain the antibacterial and anti-mite laundry detergent product.

[0014] Preferably, the ratio of glycerol, sorbitol, polyvinylpyrrolidone K30, borax, calcium chloride, deionized water, alkaline serine protease, lipase, and wash-resistant amylase in step S1 is 500-550g:200-250g:40-50g:50-55g:10-12g:600g:4-6g:2-4g:2-4g.

[0015] Preferably, the ratio of sodium alginate, sodium polyaspartate, and deionized water in step S2 is 50-70g:25-35g:300g.

[0016] Preferably, the weight-average molecular weight of the sodium polyaspartate in step S2 is 8000-14000.

[0017] Preferably, the ratio of calcium chloride, deionized water, inner phase solution, and shell phase solution used in step S3 is 100-120g:600g:250-300g:250-300g.

[0018] Preferably, the ratio of tetraethoxysilane, anhydrous ethanol, deionized water, glacial acetic acid, 3-aminopropyltriethoxysilane, and microcapsule dispersion in step S4 is 160-180g:300g:400g:10-12g:10-12g:900-1000g.

[0019] Preferably, the ratio of N,N,N-trimethyl chitosan, hydroxypropyltrimethylammonium chitosan, deionized water, sodium citrate, citric acid, polyhexamethylene biguanide hydrochloride, and dicedyldimethylammonium chloride in step S5 is 8-10g:7-8g:600g:5-7g:2-3g:5-7g:3-5g.

[0020] Preferably, the ratio of sodium silicate nonahydrate, deionized water, single-silica-shell modified microcapsule dispersion, composite nanomicelle dispersion, and calcium chloride solution in step S6 is 100-200g:300-500g:1000-1100g:300-500g:250-280g.

[0021] Preferably, the mass fraction of the calcium chloride solution in step S6 is 20%.

[0022] Preferably, the ratio of the following components in step S7 is 1600-1700g:850-900g:700-730g:200-220g:3-4g:1000-1200g:5200-5500g.

[0023] Preferably, the mass fraction of the dodecyl glucoside solution in step S7 is 50%.

[0024] Preferably, the mass fraction of the sodium myristyl alcohol polyoxyethylene ether sulfate solution in step S7 is 70%.

[0025] Preferably, the mass fraction of the sodium lauryl ether sulfate solution in step S7 is 70%.

[0026] Furthermore, the present invention also provides an antibacterial and anti-mite laundry detergent.

[0027] The beneficial effects of this invention are:

[0028] This invention utilizes an innovative multi-level microcapsule system. The gradient silica shell structure, through precise control of pore size distribution and surface chemical properties, achieves intelligent controlled release of bactericidal components, ensuring both immediate bactericidal effect and long-lasting protective effect. The unique chitosan quaternary ammonium salt nanomicelle system, by optimizing cation distribution, significantly improves the penetration of the bactericide into microbial membranes while reducing its impact on the skin's stratum corneum, thus achieving a comprehensive improvement in laundry detergent performance.

[0029] This invention utilizes a synergistic protection mechanism of borate and polyols to effectively shield the enzyme's active site from damage caused by surfactants through reversible coordination. This dynamic protective layer stabilizes the enzyme structure during storage and rapidly releases active enzyme molecules during use, resolving the inherent contradiction of balancing protection and release in traditional protection technologies.

[0030] This invention achieves efficient microcapsule preparation through an innovative membrane emulsification-in-situ condensation process, avoiding the use of organic solvents and resulting in excellent batch stability. The one-step assembly of multiple components simplifies the production process, reduces energy consumption and costs, and is more suitable for industrial-scale production. It meets diverse needs ranging from daily cleaning to professional sterilization. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments.

[0032] The properties or sources of the raw materials used in the embodiments of this invention are as follows: Sodium polyaspartate: weight average molecular weight 8000-14000; Lipase: purchased from Guangzhou Daoming Chemical Co., Ltd.: model: Lipai Yongwei 200L; Basic serine protease: purchased from Wuhan Zhonghong Biotechnology Co., Ltd., product number: 1-26, enzyme activity 20w; Wash-resistant amylase: purchased from Guangzhou Xinpu Biotechnology Co., Ltd., enzyme activity 1000; Polyhexamethylene biguanide hydrochloride: molecular weight 2800-3500; Potassium fatty acid soap: purchased from Guangzhou Wanshun Chemical Co., Ltd., model SFP-30.

[0033] Example 1: An antibacterial and anti-mite laundry detergent, the specific preparation steps are as follows:

[0034] (1) 500g glycerol, 200g sorbitol, 40g polyvinylpyrrolidone K30, 50g borax, 10g calcium chloride and 600g deionized water were stirred at 25℃ for 20min, and then 4g alkaline serine protease, 2g lipase and 2g wash-resistant amylase were added and gently stirred to obtain the inner phase solution.

[0035] (2) Dissolve 50g sodium alginate and 25g sodium polyaspartate in 300g deionized water and stir at 25℃ for 20min to obtain a shell phase solution;

[0036] (3) Dissolve 100g of calcium chloride in 600g of deionized water as a continuous phase and place it in a circulating membrane emulsification device. Use a ceramic membrane with a pore size of 2μm to push 250g of inner phase solution and 250g of shell phase solution of equal volume through the membrane surface for 30min under a transmembrane pressure difference of 0.2MPa, and obtain microcapsule dispersion with a particle size of 2-4μm.

[0037] (4) Mix 160g of tetraethoxysilane with 300g of anhydrous ethanol, 400g of deionized water and 10g of glacial acetic acid, add 10g of 3-aminopropyltriethoxysilane, and slowly add it dropwise to 900g of microcapsule dispersion at 25℃ and stir for 2h to obtain microcapsule dispersion modified with single silica shell.

[0038] (5) Dissolve 8g of N,N,N-trimethyl chitosan and 7g of hydroxypropyltrimethylammonium chitosan in 600g of deionized water and add 5g of sodium citrate and 2g of citric acid. After adjusting the pH to 6, first add 5g of polyhexamethylene biguanide hydrochloride and stir for 10min. Then add 3g of decyl dimethyl ammonium chloride and sonicate for 5min to obtain a composite nanomicelle dispersion.

[0039] (6) Dissolve 100g of sodium silicate nonahydrate in 300g of deionized water to form a water glass solution. Then, adjust the pH of 1000g of single-silica shell modified microcapsule dispersion to 10 using sodium carbonate. Add 300g of composite nano micelle dispersion, then slowly add water glass solution and react at 30℃ for 60min while atomizing and spraying in 250g of calcium chloride solution (20%) to obtain composite microcapsule dispersion.

[0040] (7) 1600g dodecyl glucoside solution (50%), 850g myristol polyoxyethylene ether sodium sulfate solution (70%), 700g lauryl polyoxyethylene ether sodium sulfate solution (70%), 200g potassium fatty acid soap, and 3g citric acid were added sequentially at room temperature and stirred evenly. Then 1000g of composite microcapsule dispersion was added, and 5500g of deionized water was added and stirred evenly to remove bubbles, thus obtaining the antibacterial and anti-mite laundry detergent product.

[0041] Example 2: An antibacterial and anti-mite laundry detergent, the specific preparation steps are as follows:

[0042] (1) 530g glycerol, 240g sorbitol, 45g polyvinylpyrrolidone K30, 53g borax, 11g calcium chloride and 600g deionized water were stirred at 25℃ for 20min, and then 5g alkaline serine protease, 3g lipase and 3g wash-resistant amylase were added and gently stirred to obtain the inner phase solution.

[0043] (2) Dissolve 60g sodium alginate and 30g sodium polyaspartate in 300g deionized water and stir at 25℃ for 25min to obtain a shell phase solution;

[0044] (3) Dissolve 110g of calcium chloride in 600g of deionized water as a continuous phase and place it in a circulating membrane emulsification device. Use a ceramic membrane with a pore size of 2μm to push 280g of inner phase solution and 280g of shell phase solution of equal volume through the membrane surface for 30min under a transmembrane pressure difference of 0.2MPa, and obtain microcapsule dispersion with a particle size of 2-4μm.

[0045] (4) Mix 170g of tetraethoxysilane with 300g of anhydrous ethanol, 400g of deionized water and 11g of glacial acetic acid, add 11g of 3-aminopropyltriethoxysilane, and slowly add it dropwise to 950g of microcapsule dispersion at 25℃ and stir for 2h to obtain microcapsule dispersion modified with single silica shell.

[0046] (5) Dissolve 9g of N,N,N-trimethyl chitosan and 7.5g of hydroxypropyltrimethylammonium chitosan in 600g of deionized water and add 6g of sodium citrate and 2.5g of citric acid. After adjusting the pH to 6, first add 6g of polyhexamethylene biguanide hydrochloride and stir for 15min. Then add 4g of decyl dimethyl ammonium chloride and sonicate for 8min to obtain a composite nanomicelle dispersion.

[0047] (6) Dissolve 150g of sodium silicate nonahydrate in 400g of deionized water to form a water glass solution. Then, adjust the pH of 1050g of single-silica shell modified microcapsule dispersion to 10 using sodium carbonate. Add 400g of composite nano micelle dispersion. Then, slowly add water glass solution and react at 30℃ for 70min while atomizing and spraying in 260g of calcium chloride solution (20%) to obtain composite microcapsule dispersion.

[0048] (7) 1650g dodecyl glucoside solution (50%), 880g myristyl alcohol polyoxyethylene ether sodium sulfate solution (70%), 710g lauryl alcohol polyoxyethylene ether sodium sulfate solution (70%), 210g fatty acid potassium soap, and 3.5g citric acid were added sequentially at room temperature and stirred evenly. Then, 1100g of composite microcapsule dispersion was added, and 5300g of deionized water was added and stirred evenly to remove bubbles, thus obtaining the antibacterial and anti-mite laundry detergent product.

[0049] Example 3: An antibacterial and anti-mite laundry detergent, the specific preparation steps are as follows:

[0050] (1) 550g glycerol, 250g sorbitol, 50g polyvinylpyrrolidone K30, 55g borax, 12g calcium chloride and 600g deionized water were stirred at 25℃ for 20min, and then 6g alkaline serine protease, 4g lipase and 4g wash-resistant amylase were added and gently stirred to obtain the inner phase solution.

[0051] (2) Dissolve 70g sodium alginate and 35g sodium polyaspartate in 300g deionized water and stir at 25℃ for 30min to obtain a shell phase solution;

[0052] (3) Dissolve 120g of calcium chloride in 600g of deionized water as a continuous phase and place it in a circulating membrane emulsification device. Use a ceramic membrane with a pore size of 2μm to push 300g of inner phase solution and 300g of shell phase solution of equal volume through the membrane surface for 30min under a transmembrane pressure difference of 0.2MPa, and obtain microcapsule dispersion with a particle size of 2-4μm.

[0053] (4) Mix 180g of tetraethoxysilane with 300g of anhydrous ethanol, 400g of deionized water and 12g of glacial acetic acid, add 12g of 3-aminopropyltriethoxysilane, and slowly add it dropwise to 1000g of microcapsule dispersion at 25℃ and stir for 2h to obtain microcapsule dispersion modified with single silica shell.

[0054] (5) Dissolve 10g N,N,N-trimethyl chitosan and 8g hydroxypropyltrimethylammonium chitosan in 600g deionized water and add 7g sodium citrate and 3g citric acid. After adjusting the pH to 6, first add 7g polyhexamethylene biguanide hydrochloride and stir for 20min. Then add 5g dicedyldimethylammonium chloride and sonicate for 10min to obtain a composite nanomicelle dispersion.

[0055] (6) Dissolve 200g of sodium silicate nonahydrate in 500g of deionized water to form a water glass solution. Then, adjust the pH of 1100g of single-silica shell modified microcapsule dispersion to 10 using sodium carbonate. Add 500g of composite nano micelle dispersion. Then, slowly add water glass solution and react at 30℃ for 90min while atomizing and spraying in 280g of calcium chloride solution (20%) to obtain composite microcapsule dispersion.

[0056] (7) 1700g dodecyl glucoside solution (50%), 900g myristyl alcohol polyoxyethylene ether sodium sulfate solution (70%), 730g lauryl alcohol polyoxyethylene ether sodium sulfate solution (70%), 220g fatty acid potassium soap, and 4g citric acid were added sequentially at room temperature and stirred evenly. Then, 1200g of composite microcapsule dispersion was added, and 5200g of deionized water was added and stirred evenly to remove bubbles, thus obtaining the antibacterial and anti-mite laundry detergent product.

[0057] Comparative Example 1: The difference from Example 2 is that water glass solution is not added in step (6), but the steps are the same as in Example 2.

[0058] Comparative Example 2: The difference from Example 2 is that in step (5), hydroxypropyltrimethylammonium chitosan is replaced with N,N,N-trimethyl chitosan, and the steps are the same as in Example 2.

[0059] Comparative Example 3: The difference from Example 2 is that calcium chloride solution is not atomized in step (6), but the steps are the same as in Example 2.

[0060] Comparative Example 4: The difference from the Example is that borax is not added in step (1), but the steps are the same as in Example 2.

[0061] Performance testing

[0062] Antibacterial performance test: The specific method and steps are as follows: Preparation of bacterial suspension: Staphylococcus aureus (ATCC 6538) was inoculated into nutrient broth and cultured at 37°C for 18 h, then diluted with PBS to 1×10⁻⁶. 6 CFU / mL; Take 10mL of the finished laundry detergent and 90mL of sterile hard water (Ca). 2+ :Mg 2+ Mix (2:1 ratio, hardness 150 mg / L), add 1 mL of bacterial suspension, and incubate at 25°C for 5 min; terminate the reaction by adding D / E neutralization solution containing 0.5% sodium thiosulfate; count surviving colonies using the pour plate method and calculate the inhibition rate;

[0063] Mite removal effect test: Take 10mL of the laundry detergent obtained in the example and comparative example, dilute it to 1L of working solution to form the experimental group, and the control group is an equal volume of deionized water;

[0064] Mite culture: Collect live mites from petri dishes and prepare a suspension with a concentration of ≥1000 mites / mL using physiological saline. Take 100 μL of the suspension and drop it evenly onto a 1cm×1cm pure cotton cloth. Add 50 μL of undiluted laundry detergent directly to the mite suspension and observe the mite mortality rate within 30 minutes under a microscope.

[0065] Enzyme activity retention rate (protease) test: The test was conducted according to GB / T 23527-2009. The test method is as follows: The laundry detergent was placed in a 40℃ constant temperature chamber for accelerated aging for 6 months. The casein substrate method was used, and the reaction was carried out at 37℃ for 10 minutes. The absorbance at 280nm was measured by a UV spectrophotometer.

[0066] Skin irritation test: The test was conducted according to GB / T 21827-2008. Healthy adult albino rabbits were selected as experimental subjects. The hair on the back of the rabbits was shaved. The samples obtained from the examples and comparative examples were diluted at a ratio of 1:10 and evenly applied to the skin. The skin was covered with gauze and fixed. After 4 hours, the residue was gently rinsed off with warm water. Erythema, edema and other reactions were recorded after 48 hours. The results were evaluated according to the prescribed scoring criteria. The test results are shown in Table 1.

[0067] Table 1 Performance Test Results

[0068] Antibacterial rate (%) Mite removal rate (%) Enzyme activity retention rate (%) Irritating Example 1 99.5 97.8 91.5 0.8 Example 2 99.8 98.5 92.3 0.7 Example 3 99.6 98.2 90.8 0.9 Comparative Example 1 95.2 89.3 85.2 1.0 Comparative Example 2 97.3 92.4 88.6 1.2 Comparative Example 3 93.5 86.7 82.4 1.3 Comparative Example 4 85.6 75.2 68.5 1.5

[0069] Data Analysis: Data from Examples 1-3 in Table 1 show that the antibacterial and anti-mite laundry detergent prepared by this invention exhibits excellent comprehensive performance: its high antibacterial and anti-mite rates indicate that the microencapsulated sterilization system has a significant synergistic effect, which may be due to the gradient silica shell structure enabling intelligent controlled release of the bactericide; the excellent enzyme activity retention rate suggests that the borate coordination protection mechanism effectively stabilizes the enzyme molecular conformation, possibly shielding the enzyme's active site from surfactant damage through reversible borate-diol bonding; the extremely low skin irritation reflects that the cationic modification of chitosan quaternary ammonium salt nanomicelles optimizes the charge distribution of the bactericide, reducing its permeability to the stratum corneum while maintaining bactericidal efficacy. This combination of performance indicates that this technical solution achieves synergistic optimization of multiple performance parameters, including bactericidal activity, enzyme activity, and mildness.

[0070] A comparison of the data from Example 2 and Comparative Example 1 in Table 1 shows that the porous silica network formed by the water glass solution under alkaline conditions, together with the inner dense silica shell, constitutes a physical barrier. This effectively blocks the penetration of bactericides into the microcapsules and allows for the on-demand release of bactericidal components through mechanical shearing during washing. Without the outer silica shell, the bactericide may be released prematurely or unevenly, leading to a decrease in antibacterial and anti-mite effects. At the same time, the double-shell structure provides more complete protection for enzyme molecules and reduces the denaturing effect of surfactants on enzyme proteins through steric hindrance, which may be the reason for the higher enzyme activity retention rate in Example 2.

[0071] As can be seen from the data comparison between Example 2 and Comparative Example 2 in Table 1, the composite chitosan system used in this invention may form a more stable nanomicelle structure through the reasonable distribution of hydrophobic and hydrophilic groups in the molecular chain. This structure can effectively load bactericide molecules and achieve the gradual release of bactericidal components during the washing process. It can capture and release polyhexamethylene biguanide hydrochloride and dicedyldimethylammonium chloride in a staggered manner, thereby weakening their synergistic destabilization.

[0072] A comparison of the data from Example 2 and Comparative Example 3 in Table 1 shows that the calcium mist spray bridging shell used in this invention forms a "grafted" Si–Ca–alginic acid ternary network. Under alkaline conditions, water glass rapidly condenses to form a porous outer silica network, which, together with the dense inner silicon layer, constitutes a gradient double silicon shell. Simultaneously, sprayed calcium ions form a shield and weak coordination bridging between the carboxyl groups of alginate and silanol, limiting the excessive penetration of nanomicelles and constructing reversible adsorption sites to achieve graded release behavior. This structural design allows the bactericide to be more uniformly distributed on the surface of the microcapsules, ensuring both immediate bactericidal effect and long-term protective effect.

[0073] As can be seen from the data comparison between Example 2 and Comparative Example 4 in Table 1, the borax protection mechanism adopted in this invention may be achieved through its reversible coordination with the hydroxyl groups on the enzyme molecule surface, while the reversible inhibition of the internal phase borate and the synergistic protection of polyol and polyvinylpyrrolidone form a dynamic protective layer. This can effectively shield the enzyme's active site from external environmental damage and restore enzyme activity through the competitive action of water molecules during washing. This forms a unique mechanism that inhibits structural loosening during the formulation and storage stages and reversibly releases and restores activity during the dilution stage. This not only improves the storage stability of the enzyme but may also indirectly enhance the synergistic effect of the bactericidal system by maintaining the integrity of the enzyme structure.

[0074] Those skilled in the art should understand that the discussion of any of the above embodiments is merely exemplary and is not intended to imply that the scope of the invention is limited to these examples; within the framework of the invention, the technical features of the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity.

Claims

1. A method for preparing an antibacterial and anti-mite laundry detergent, characterized in that, Includes the following steps: S1: Glycerol, sorbitol, polyvinylpyrrolidone K30, borax, calcium chloride and deionized water are mixed and then alkaline serine protease, lipase and wash-resistant amylase are added and stirred to obtain an inner phase solution. S2: Dissolve sodium alginate and sodium polyaspartate in deionized water to obtain a shell phase solution; S3: In a circulating membrane emulsification device, calcium chloride is dissolved in deionized water as a continuous phase, and the inner phase solution and the shell phase solution are added in equal volumes to obtain a microcapsule dispersion; S4: Tetraethoxysilane was mixed with anhydrous ethanol, deionized water and glacial acetic acid, and 3-aminopropyltriethoxysilane was added and mixed well. The mixture was then added dropwise to the microcapsule dispersion to obtain a single-silica-shell modified microcapsule dispersion. S5: N,N,N-trimethyl chitosan and hydroxypropyltrimethylammonium chitosan were dissolved in deionized water, and sodium citrate and citric acid were added and mixed. Then polyhexamethylene biguanide hydrochloride and decyl dimethyl ammonium chloride were added to obtain a composite nanomicelle dispersion. S6: Dissolve sodium silicate nonahydrate in deionized water to form a water glass solution. After adjusting the pH of the single-silica shell modified microcapsule dispersion to 10, add the composite nanomicelle dispersion and water glass solution. React at 30℃ for 60-90 min. At the same time, atomize and spray calcium chloride solution to obtain the composite microcapsule dispersion. S7: At room temperature, mix dodecyl glucoside solution, myristol polyoxyethylene ether sodium sulfate solution, lauryl polyoxyethylene ether sodium sulfate solution, potassium fatty acid soap, and citric acid, then add the composite microcapsule dispersion, add deionized water, stir evenly, and defoam to obtain the antibacterial and anti-mite laundry detergent product.

2. The preparation method according to claim 1, characterized in that, The ratio of glycerol, sorbitol, polyvinylpyrrolidone K30, borax, calcium chloride, deionized water, alkaline serine protease, lipase, and wash-resistant amylase in step S1 is 500-550g:200-250g:40-50g:50-55g:10-12g:600g:4-6g:2-4g:2-4g.

3. The preparation method according to claim 1, characterized in that, The ratio of sodium alginate, sodium polyaspartate, and deionized water used in step S2 is 50-70g: 25-35g: 300g.

4. The preparation method according to claim 1, characterized in that, The weight-average molecular weight of the polyaspartic acid sodium salt in step S2 is 8000-14000.

5. The preparation method according to claim 1, characterized in that, The ratio of calcium chloride, deionized water, inner phase solution, and shell phase solution used in step S3 is 100-120g:600g:250-300g:250-300g.

6. The preparation method according to claim 1, characterized in that, The ratio of tetraethoxysilane, anhydrous ethanol, deionized water, glacial acetic acid, 3-aminopropyltriethoxysilane, and microcapsule dispersion in step S4 is 160-180g:300g:400g:10-12g:10-12g:900-1000g.

7. The preparation method according to claim 1, characterized in that, The ratio of N,N,N-trimethyl chitosan, hydroxypropyltrimethylammonium chitosan, deionized water, sodium citrate, citric acid, polyhexamethylene biguanide hydrochloride, and dicedyldimethylammonium chloride in step S5 is 8-10g:7-8g:600g:5-7g:2-3g:5-7g:3-5g.

8. The preparation method according to claim 1, characterized in that, The ratio of sodium silicate nonahydrate, deionized water, single-silica-shell modified microcapsule dispersion, composite nanomicelle dispersion, and calcium chloride solution in step S6 is 100-200g:300-500g:1000-1100g:300-500g:250-280g.

9. The preparation method according to claim 1, characterized in that, The ratio of the following components in step S7 is: dodecyl glucoside solution, myristyl alcohol polyoxyethylene ether sodium sulfate solution, lauryl alcohol polyoxyethylene ether sodium sulfate solution, potassium fatty acid soap, citric acid, composite microcapsule dispersion, and deionized water: 1600-1700g: 850-900g: 700-730g: 200-220g: 3-4g: 1000-1200g: 5200-5500g.

10. A bactericidal and mite-removing laundry detergent, characterized in that, It is prepared according to any one of claims 1-9.