Application of chitosan oligosaccharide in relieving cow milk allergy and regulating immunity

By administering water-soluble chitosan oligosaccharides with a degree of deacetylation ≥90% and a molecular weight of 340–1630 Da at different stages, the immune balance and gut microbiota of children with milk allergy were regulated, solving the problems of long treatment courses and poor compliance in the treatment of milk allergy, and achieving significant relief and safety.

CN121549540APending Publication Date: 2026-02-24DALIAN POLYTECHNIC UNIVERSITY
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Patent Information

Application Number
CN202511250697.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-03
Publication Date
2026-02-24

AI Technical Summary

Technical Problem

Existing treatments for cow's milk allergy involve long treatment courses, poor patient compliance, and unstable efficacy. Probiotic interventions also have limited effectiveness.

Method used

Water-soluble chitosan oligosaccharides with a degree of deacetylation ≥90% and a molecular weight of 340–1630 Da are administered to infants with milk allergies at different stages before, during, or after milk protein sensitization. By regulating the immune balance of Th1, Th2, and Th17 and restoring intestinal flora homeostasis, functional food or pharmaceutical compositions can be prepared.

Benefits of technology

It significantly alleviates symptoms of milk allergy, regulates immune response, restores gut microbiota homeostasis, and improves intestinal tissue damage. It has multi-stage applicability, synergistic effects on multiple immune targets, and good safety.

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Abstract

The invention relates to the field of application of food functional factors, and particularly discloses a method for relieving cow milk allergy by using chitosan oligosaccharide and application. According to the method, chitosan oligosaccharide is given before sensitization, during sensitization or after sensitization; the chitosan oligosaccharide can be used for remarkably reducing the levels of serum IgE (Immunoglobulin E), IgG1 (Immunoglobulin G1), IL-4 (Interleukin-4), IL-10 (Interleukin-10), IL-17A (Interleukin-10), histamine and mast cell proteinase-1, and increasing the expression of IFN (Interferon)-gamma to regulate the immune balance of Th1 / Th2 / Th17; the alpha diversity and beta diversity of intestinal flora are improved, and the stable state of the flora is recovered; the allergy symptoms are relieved; the intestinal tract tissue injury is repaired. The chitosan oligosaccharide can be used for preparing functional foods or compositions for resisting cow milk allergy, and has application prospects in infant formula foods, solid beverages and dairy products.
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