A near-infrared fluorescent viscosity probe and a preparation method and application thereof
By designing a near-infrared fluorescent viscosity probe, the problems of insufficient sensitivity and aggregation quenching in the early diagnosis of arthritis were solved, enabling rapid and accurate imaging of arthritis lesions and providing a solution with high viscosity response and good biocompatibility.
Patent Information
- Application Number
- CN202610314745.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-16
- Publication Date
- 2026-06-23
- Estimated Expiration
- 2046-03-16
AI Technical Summary
Existing fluorescence imaging techniques lack sensitivity in the early diagnosis of arthritis, cannot effectively monitor viscosity changes at the cellular and subcellular levels, and traditional fluorescent probes suffer from aggregation leading to quenching. There is also a lack of arthritis-specific imaging tools.
A near-infrared fluorescent viscosity probe was developed, employing a donor-π-acceptor (D-π-A) structure containing a triphenylamine (TPA) group and a pyrene-oxadiazole structure. This probe exhibits aggregation-induced emission properties and high viscosity sensitivity, making it suitable for arthritis imaging.
It enables rapid and accurate imaging of arthritis lesions, overcomes the problem of aggregation and quenching, has high viscosity response sensitivity and good biocompatibility, and can provide stable fluorescence signals in a short time. It is suitable for the diagnosis and pathological research of rheumatoid arthritis and osteoarthritis.