Suspended graphene field effect transistor, preparation method thereof and application of suspended graphene field effect transistor in biosensor
By etching grooves on a substrate and depositing a monolayer graphene film to form a suspended graphene field-effect transistor, combined with surface functionalization reagents and detection probes, the sensitivity and operational complexity issues of miR-21 detection in existing technologies have been solved, achieving highly sensitive label-free detection and advancing early cancer diagnosis.
CN121994894APending Publication Date: 2026-05-08JIMEI UNIV
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Patent Information
- Application Number
- CN202610199704.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-11
- Publication Date
- 2026-05-08
AI Technical Summary
Technical Problem
Existing miR-21 detection methods, such as quantitative polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA), have limitations in sensitivity and operational complexity, making it difficult to achieve rapid and sensitive label-free detection.
Method used
A suspended graphene field-effect transistor was designed. By etching grooves on a substrate and depositing a monolayer graphene film to form a suspended structure, and combining surface functionalized reagents and detection probes, label-free detection of miR-21 was achieved.
Benefits of technology
It achieves high-sensitivity detection of miR-21, with a detection limit on the femtomolar scale, reduces noise and enhances signal transmission, providing a technical approach for early cancer diagnosis.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of biomarker detection, and particularly relates to a suspended graphene field effect transistor, a preparation method thereof and application of the suspended graphene field effect transistor in a biosensor. The suspended graphene field effect transistor provided by the invention comprises a substrate, wherein a groove is formed in the upper surface of the substrate; the insulating layers are arranged on the upper surface, except for the groove, of the substrate, the side wall of the groove and the bottom surface of the groove, the electrode layers are arranged on the upper surfaces of the insulating layers and comprise source electrodes and drain electrodes, and the source electrodes and the drain electrodes are located on the upper surfaces of the insulating layers on the two sides of the groove respectively; and the single-layer graphene film is arranged on the upper surface of the electrode layer, covers the groove and is communicated with the source electrode and the drain electrode. The suspended graphene field effect transistor provided by the invention can realize miR-21 detection without marking, is high in detection sensitivity and low in detection limit, can realize miR-21 detection in a fly mole magnitude, and provides a technical approach for promoting early cancer diagnosis.
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