A medical dressing made of liquid metal composite nanoclay

Abstract

This invention relates to the field of medical dressing technology, and discloses a medical dressing based on a liquid metal composite nanoclay. The dressing core material is prepared by ultrasonic mixing of gallium-based liquid metal and halloysite nanoparticles as core functional components. The core material is uniformly coated onto the surface of a double-sided coated fabric, with the outermost layer of the fabric covered by a breathable polyethylene (PE) film. By adjusting the ratio of gallium-based liquid metal to halloysite nanoparticles, the hardness, softness, and other physical properties of the dressing can be adjusted to suit different types of wounds. This invention organically combines liquid metal and nanoclay, possessing the performance advantages of both. It exhibits excellent antibacterial properties, biocompatibility, and environmental stability, creating a sterile and moist microenvironment for wound healing, promoting wound healing. Furthermore, the preparation process is simple, the structure is convenient, and the core material is recyclable, effectively reducing medical costs and showing promising application prospects in clinical wound care.

Description

Technical Field

[0001] This invention relates to the field of medical dressing technology, specifically to a medical dressing made of liquid metal composite nanoclay. Background Technology

[0002] Traditional medical dressings are mainly made of natural fiber materials such as gauze and cotton, which can provide basic isolation and protection in clinical wound care. However, they have many insurmountable drawbacks in practical application. Traditional dressings are highly absorbent, which can easily lead to excessive drying of the wound surface, hindering the migration of epithelial cells and wound healing. Furthermore, dressings tend to adhere to newly formed granulation tissue during dressing changes, and removal can cause secondary damage to the wound, increasing patient discomfort. At the same time, traditional dressings lack active antibacterial properties; they can only reduce the invasion of external bacteria through physical isolation and cannot effectively inhibit existing bacteria in the wound surface, making them prone to infection and unable to meet the nursing needs of complex wounds such as chronic, difficult-to-heal wounds and burns.

[0003] Furthermore, traditional dressings have poor deformability and plasticity, making them unsuitable for fitting irregular wounds and unable to provide additional functions such as electrical stimulation and temperature control to promote wound healing. They are no longer adequate for the diverse needs of modern clinical wound care. With the development of materials science, liquid metals and nanoclay materials are increasingly being applied in the biomedical field. Liquid metals combine the electrical and thermal conductivity of metallic materials with the fluidity and deformability of liquid materials, while also possessing good biocompatibility. The metal ions they release can achieve broad-spectrum antibacterial effects and can promote local blood circulation in the wound through thermal conductivity, accelerating wound healing. Nanoclay, consisting of layered mineral silicate nanoparticles, has a high specific surface area, excellent adsorption properties, and biocompatibility. It can effectively adsorb bacteria and toxins in wound exudate, reducing the risk of wound infection, while maintaining a moist microenvironment on the wound surface, providing favorable conditions for wound healing.

[0004] Existing research and preliminary attempts on these two types of materials still face technical bottlenecks in their combined application: gallium-based liquid metals have high surface tension, making it difficult to achieve uniform and stable composites with inorganic nano-clay particles, which easily leads to phase separation and uneven dispersion, thus failing to stably exert their synergistic properties; at the same time, it is difficult to balance fluidity, deformability, and mechanical strength after the two are combined, making it impossible to simultaneously meet the requirements of wound adhesion and structural stability, and it is also difficult to achieve efficient composites of the two through simple and controllable processes to construct dressing structures that meet clinical needs. Summary of the Invention

[0005] The present invention aims to provide a medical dressing of liquid metal composite nano-clay to solve the problems of insufficient antibacterial properties, easy secondary damage, and poor healing effect of traditional medical dressings.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a medical dressing of liquid metal composite nanoclay, comprising a dressing core material, a double-sided coated fabric, and a breathable polyethylene film; the dressing core material is uniformly coated on the surface of the double-sided coated fabric, and the breathable polyethylene film covers the outermost layer of the dressing core material; the dressing core material is prepared by ultrasonic mixing of gallium-based liquid metal and halloysite nanoparticles.

[0007] Preferably, as an improvement, the mass ratio of the gallium-based liquid metal to the halloysite nanoparticles is 1:9 to 9:1.

[0008] Preferably, as an improvement, the gallium-based liquid metal is any one of gallium-indium alloy and gallium-indium-tin alloy, which are liquid at room temperature.

[0009] Preferably, as an improvement, the halloysite nanoparticles are tubular natural halloysite nanoclay particles.

[0010] Preferably, as an improvement, the double-coated fabric is a medical-grade double-coated nonwoven fabric or a medical-grade double-coated gauze.

[0011] A method for preparing a medical dressing based on liquid metal composite nanoclay includes the following steps: Step 1: Prepare materials by weighing a predetermined amount of gallium-based liquid metal and halloysite nanoparticles; Step 2: Mixing preparation. The weighed gallium-based liquid metal is mixed with halloysite nanoparticles and ultrasonically treated using an ultrasonic mixer to prepare the dressing core material. Step 3: Dressing Forming. The prepared dressing core material is uniformly coated onto the surface of a double-coated fabric, and then a breathable polyethylene film is covered on the outermost layer of the dressing core material to obtain the medical dressing.

[0012] Preferably, as an improvement, in step 2, the ultrasonic power is 200W~1200W and the ultrasonic treatment time is 5min~60min.

[0013] Preferably, as an improvement, in step 3, the coating thickness of the dressing core material on the surface of the double-sided coated fabric is 0.1 mm to 2 mm.

[0014] The advantages of this solution are: 1. By organically combining gallium-based liquid metal with halloysite nanoparticles as the core functional material of the dressing, the synergistic effect of the two can be brought into play. Halloysite nanoparticles disperse liquid metal to solve the agglomeration problem, and liquid metal ions realize the slow release of antibacterial components. The two work together to achieve multiple functions such as broad-spectrum antibacterial, exudate adsorption, and blood circulation promotion, creating a sterile and moist microenvironment for wound healing. 2. This invention can flexibly adjust the physical properties of dressings, such as hardness and softness, by adjusting the ratio of gallium-based liquid metal to halloysite nanoparticles. It can adapt to different types of wounds, such as flat wounds, irregular wounds, and cavity wounds, thereby improving the fit and applicability of the dressing. 3. The gallium-based liquid metal and halloysite nanoparticles used in this invention have excellent biocompatibility, are non-cytotoxic and immunogenic, and are not prone to adhesion to wound surfaces during use, which can avoid secondary damage during dressing changes and improve the safety and patient comfort of clinical use. 4. The dressing structure of the present invention is simple, the preparation process is simple and controllable, no complex production equipment and process flow are required, and it can achieve large-scale mass production, effectively reducing the production and use costs of medical dressings; 5. The core material of the dressing of the present invention has the characteristic of being recyclable, which can effectively reduce the generation of medical waste, reduce the environmental pollution caused by medical waste, and has good environmental benefits; 6. The outermost layer of the dressing of the present invention is provided with a breathable polyethylene film, which can achieve isolation and protection against external water and bacteria while ensuring the breathability of the dressing, further reducing the risk of wound infection and improving the protective performance of the dressing. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of a medical dressing based on a liquid metal composite nanoclay according to the present invention. Figure 2 This is a scanning electron microscope image of liquid metal composite nanoclay.

[0016] The reference numerals in the accompanying drawings include: 1. polyethylene film; 2. double-sided coated fabric; 3. gallium-based liquid metal; 4. halloysite nanotube. Detailed Implementation

[0017] The following detailed description illustrates the specific implementation methods: The basic implementation examples are as follows: Figures 1-2 As shown: A medical dressing based on liquid metal composite nanoclay includes a dressing core material, a double-sided coated fabric, and a breathable polyethylene film. The dressing core material is uniformly coated on the surface of the double-sided coated fabric, which is water-based polyurethane. The breathable polyethylene film completely covers the outermost layer of the double-sided coated fabric, forming a complete layered dressing structure. The dressing core material is prepared by ultrasonic treatment of gallium-based liquid metal and halloysite nanoparticles using an ultrasonic mixer. The gallium-based liquid metal used is a gallium-indium-tin alloy that is liquid at room temperature. This alloy has stable liquid properties at room temperature, excellent fluidity and deformability, and good biocompatibility and metal ion sustained-release performance. The halloysite nanoparticles used are natural tubular halloysite nanoclay particles with a large specific surface area and excellent adsorption performance. They can effectively adsorb wound exudate and bacterial toxins, and also have good biodegradability and biocompatibility.

[0018] A method for preparing a medical dressing based on liquid metal composite nanoclay is as follows: First, the gallium indium tin alloy (GaInT) and halloysite nanoparticles were weighed according to a mass ratio of 5:1. The weighed materials were then placed in a sterile container and thoroughly premixed. The premixed materials were then transferred to an ultrasonic mixer, with an ultrasonic power of 600W and an ultrasonic treatment time of 30 minutes. Under ultrasonic action, the gallium-based liquid metal and halloysite nanoparticles were fully dispersed and combined to form a uniform and stable dressing core material. Subsequently, the prepared dressing core material was uniformly coated onto the surface of medical-grade double-sided coated gauze, with a coating thickness controlled at 0.5 mm. After coating, a layer of medical-grade breathable polyethylene film was completely covered on the outermost layer of the double-sided coated gauze. Breathable polyethylene films with different porosities and thicknesses were purchased, with a breathability of 3000 g / (m²) selected. A breathable polyethylene membrane (24h) was used to ultimately produce a novel medical dressing made of liquid metal and nano-clay.

[0019] The above descriptions are merely embodiments of the present invention, and common knowledge such as specific technical solutions and / or characteristics are not described in detail here. It should be noted that those skilled in the art can make various modifications and improvements without departing from the technical solutions of the present invention, and these should also be considered within the scope of protection of the present invention. These modifications and improvements will not affect the effectiveness of the implementation of the present invention or the practicality of the patent. The scope of protection claimed in this application should be determined by the content of its claims, and the specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A medical dressing made of liquid metal composite nanoclay, characterized in that: It includes a dressing core material, a double-sided coated fabric, and a breathable polyethylene film; the dressing core material is uniformly coated on the surface of the double-sided coated fabric, and the breathable polyethylene film covers the outermost layer of the dressing core material; The core material of the dressing is prepared by ultrasonic mixing of gallium-based liquid metal and halloysite nanoparticles.

2. The medical dressing of liquid metal composite nanoclay according to claim 1, characterized in that: The mass ratio of the gallium-based liquid metal to the halloysite nanoparticles is 1:9 to 9:

1.

3. The medical dressing of liquid metal composite nanoclay according to claim 2, characterized in that: The gallium-based liquid metal is either a gallium-indium alloy or a gallium-indium-tin alloy that is liquid at room temperature.

4. The medical dressing of liquid metal composite nanoclay according to claim 3, characterized in that: The halloysite nanoparticles are natural halloysite nano-clay particles with a tubular structure.

5. The medical dressing of liquid metal composite nanoclay according to claim 4, characterized in that: The double-sided coated fabric is medical-grade double-sided coated non-woven fabric or medical-grade double-sided coated gauze.

6. A method for preparing a medical dressing of liquid metal composite nanoclay, characterized in that, Includes the following steps: Step 1: Prepare materials by weighing a predetermined amount of gallium-based liquid metal and halloysite nanoparticles; Step 2: Mixing preparation. The weighed gallium-based liquid metal is mixed with halloysite nanoparticles and ultrasonically treated using an ultrasonic mixer to prepare the dressing core material. Step 3: Dressing Forming. The prepared dressing core material is uniformly coated onto the surface of a double-coated fabric, and then a breathable polyethylene film is covered on the outermost layer of the dressing core material to obtain the medical dressing.

7. The method for preparing a medical dressing of liquid metal composite nanoclay according to claim 6, characterized in that: In step 2, the ultrasonic power is 200W~1200W and the ultrasonic treatment time is 5min~60min.

8. The method for preparing a medical dressing of liquid metal composite nanoclay according to claim 7, characterized in that: In step 3, the coating thickness of the dressing core material on the surface of the double-sided coated fabric is 0.1mm to 2mm.

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